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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs209163
log Bayes Factor = 52.4986
Chromosome 6   position 28,836,817  (GRCh37) Explore rs209163 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
E10.9 Without complications
0.000 0.002 0.998
E10-E14 Diabetes mellitus
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E00-E07 Disorders of thyroid gland
0.000 0.005 0.995
E10.3 With ophthalmic complications
0.000 0.006 0.994
E10.2 With renal complications
0.000 0.049 0.951
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.052 0.948
E10.4 With neurological complications
0.000 0.091 0.909
E10.1 With ketoacidosis
0.000 0.093 0.907
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.893 0.107 0.000
E13 Other specified diabetes mellitus
0.000 0.164 0.836
E05.8 Other thyrotoxicosis
0.000 0.165 0.835
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.212 0.788
E16.1 Other hypoglycaemia
0.000 0.223 0.777
E10.7 With multiple complications
0.000 0.251 0.748
E14 Unspecified diabetes mellitus
0.000 0.266 0.734
E10.0 With coma
0.000 0.281 0.719
E13.9 Without complications
0.000 0.282 0.718
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.286 0.714
E00 Congenital iodine-deficiency syndrome
0.000 0.286 0.714
E40-E46 Malnutrition
0.000 0.331 0.669
E10.6 With other specified complications
0.000 0.334 0.666
E07 Other disorders of thyroid
0.000 0.353 0.647
E14.3 With ophthalmic complications
0.000 0.359 0.641
E10.5 With peripheral circulatory complications
0.000 0.360 0.640
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.363 0.636
E06 Thyroiditis
0.000 0.383 0.617
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.394 0.606
E13.3 With ophthalmic complications
0.000 0.397 0.603
E13.8 With unspecified complications
0.000 0.401 0.599
E13.7 With multiple complications
0.000 0.401 0.599
E13.6 With other specified complications
0.000 0.401 0.599
E13.5 With peripheral circulatory complications
0.000 0.401 0.599
E13.4 With neurological complications
0.000 0.401 0.599
E13.2 With renal complications
0.000 0.401 0.599
E13.1 With ketoacidosis
0.000 0.401 0.599
E13.0 With coma
0.000 0.401 0.599
E14.1 With ketoacidosis
0.000 0.408 0.591
E14.6 With other specified complications
0.000 0.443 0.557
E14.4 With neurological complications
0.000 0.455 0.545
E10.8 With unspecified complications
0.000 0.465 0.535
E14.8 With unspecified complications
0.000 0.468 0.531
E07.8 Other specified disorders of thyroid
0.000 0.474 0.526
E14.7 With multiple complications
0.000 0.474 0.526
E14.5 With peripheral circulatory complications
0.000 0.482 0.518
E12.9 Without complications
0.000 0.487 0.513
E12.8 With unspecified complications
0.000 0.487 0.513
E12.7 With multiple complications
0.000 0.487 0.513
E12.6 With other specified complications
0.000 0.487 0.513
E12.5 With peripheral circulatory complications
0.000 0.487 0.513
E12.4 With neurological complications
0.000 0.487 0.513
E12.3 With ophthalmic complications
0.000 0.487 0.513
E12.2 With renal complications
0.000 0.487 0.513
E12.1 With ketoacidosis
0.000 0.487 0.513
E12.0 With coma
0.000 0.487 0.513
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.488 0.512
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.488 0.512
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.488 0.512
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.488 0.512
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.488 0.512
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.488 0.512
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.488 0.512
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.488 0.512
E14.2 Withrenal complications
0.000 0.498 0.502
E06.9 Thyroiditis, unspecified
0.000 0.503 0.497
E14.0 With coma
0.000 0.508 0.492
E06.1 Subacute thyroiditis
0.000 0.520 0.480
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.520 0.479
E45 Retarded development following protein-energy malnutrition
0.000 0.520 0.479
E43 Unspecified severe protein-energy malnutrition
0.000 0.520 0.479
E42 Marasmic kwashiorkor
0.000 0.520 0.479
E41 Nutritional marasmus
0.000 0.520 0.479
E40 Kwashiorkor
0.000 0.520 0.479
E07.1 Dyshormogenetic goitre
0.000 0.536 0.464
E07.0 Hypersecretion of calcitonin
0.000 0.536 0.464
E06.4 Drug-induced thyroiditis
0.000 0.558 0.442
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.558 0.442
E06.0 Acute thyroiditis
0.000 0.558 0.442
E46 Unspecified protein-energy malnutrition
0.000 0.567 0.433
E06.5 Other chronic thyroiditis
0.000 0.576 0.424
E03 Other hypothyroidism
0.000 0.593 0.407
K90 Intestinal malabsorption
0.000 0.606 0.394
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.618 0.382
E11 Non-insulin-dependent diabetes mellitus
0.000 0.650 0.350
E44.1 Mild protein-energy malnutrition
0.000 0.656 0.344
E44.0 Moderate protein-energy malnutrition
0.000 0.656 0.344
E50-E64 Other nutritional deficiencies
0.000 0.657 0.343
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.666 0.334
E11.6 With other specified complications
0.000 0.673 0.327
E65-E68 Obesity and other hyperalimentation
0.000 0.680 0.320
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.695 0.304
E11.1 With ketoacidosis
0.000 0.701 0.299
E03.5 Myxoedema coma
0.000 0.708 0.292
E03.4 Atrophy of thyroid (acquired)
0.000 0.708 0.292
E03.3 Postinfectious hypothyroidism
0.000 0.708 0.292
E11.0 With coma
0.000 0.711 0.289
K90.3 Pancreatic steatorrhoea
0.000 0.717 0.283
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.717 0.283
K90.1 Tropical sprue
0.000 0.717 0.283
E03.1 Congenital hypothyroidism without goitre
0.000 0.719 0.281
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.720 0.279
K90.8 Other intestinal malabsorption
0.000 0.730 0.269
E07.9 Disorder of thyroid, unspecified
0.000 0.733 0.267
E03.8 Other specified hypothyroidism
0.000 0.742 0.258
E11.7 With multiple complications
0.000 0.749 0.251
E54 Ascorbic acid deficiency
0.000 0.750 0.250
E11.2 With renal complications
0.000 0.750 0.250
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.754 0.246
E63 Other nutritional deficiencies
0.000 0.754 0.246
E50 Vitamin A deficiency
0.000 0.754 0.246
E60 Dietary zinc deficiency
0.000 0.754 0.246
E59 Dietary selenium deficiency
0.000 0.754 0.246
E52 Niacin deficiency [pellagra]
0.000 0.754 0.246
E51 Thiamine deficiency
0.000 0.756 0.244
E56 Other vitamin deficiencies
0.000 0.768 0.232
E55 Vitamin D deficiency
0.000 0.770 0.230
E67 Other hyperalimentation
0.000 0.770 0.230
E68 Sequelae of hyperalimentation
0.000 0.770 0.230
E58 Dietary calcium deficiency
0.000 0.787 0.213
E20-E35 Disorders of other endocrine glands
0.000 0.787 0.213
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.788 0.212
E11.8 With unspecified complications
0.000 0.794 0.206
E24 Cushing's syndrome
0.000 0.808 0.192
E61 Deficiency of other nutrient elements
0.000 0.811 0.189
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.819 0.181
K90.9 Intestinal malabsorption, unspecified
0.000 0.821 0.179
I83 Varicose veins of lower extremities
0.178 0.822 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.823 0.176
E50.8 Other manifestations of vitamin A deficiency
0.000 0.823 0.176
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.823 0.176
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.823 0.176
E50.5 Vitamin A deficiency with night blindness
0.000 0.823 0.176
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.823 0.176
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.823 0.176
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.823 0.176
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.823 0.176
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.823 0.176
E63.9 Nutritional deficiency, unspecified
0.000 0.823 0.176
E63.8 Other specified nutritional deficiencies
0.000 0.823 0.176
E63.1 Imbalance of constituents of food intake
0.000 0.823 0.176
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.823 0.176
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.823 0.176
E64.8 Sequelae of other nutritional deficiencies
0.000 0.823 0.176
E64.3 Sequelae of rickets
0.000 0.823 0.176
E64.2 Sequelae of vitamin C deficiency
0.000 0.823 0.176
E64.1 Sequelae of vitamin A deficiency
0.000 0.823 0.176
E64.0 Sequelae of protein-energy malnutrition
0.000 0.823 0.176
E51.9 Thiamine deficiency, unspecified
0.000 0.825 0.175
E51.8 Other manifestations of thiamine deficiency
0.000 0.825 0.175
E51.1 Beriberi
0.000 0.825 0.175
E83 Disorders of mineral metabolism
0.143 0.825 0.032
E53 Deficiency of other B group vitamins
0.000 0.826 0.174
E51.2 Wernicke's encephalopathy
0.000 0.826 0.173
E65 Localised adiposity
0.000 0.829 0.170
E21.3 Hyperparathyroidism, unspecified
0.000 0.830 0.170
E11.5 With peripheral circulatory complications
0.000 0.830 0.170
E56.9 Vitamin deficiency, unspecified
0.000 0.833 0.166
E56.8 Deficiency of other vitamins
0.000 0.833 0.166
E56.0 Deficiency of vitamin E
0.000 0.833 0.166
E55.0 Rickets, active
0.000 0.835 0.165
E67.8 Other specified hyperalimentation
0.000 0.835 0.165
E67.3 Hypervitaminosis D
0.000 0.835 0.165
E67.2 Megavitamin-B6 syndrome
0.000 0.835 0.165
E67.1 Hypercarotenaemia
0.000 0.835 0.165
E67.0 Hypervitaminosis A
0.000 0.835 0.165
E24.9 Cushing's syndrome, unspecified
0.000 0.836 0.164
E06.3 Autoimmune thyroiditis
0.000 0.836 0.163
M45.X9 Ankylosing spondylitis (Site unspecified)
0.160 0.840 0.000
E24.0 Pituitary-dependent Cushing's disease
0.000 0.841 0.159
E20 Hypoparathyroidism
0.000 0.841 0.159
C15-C26 Malignant neoplasms of digestive organs
0.000 0.843 0.157
C20 Malignant neoplasm of rectum
0.000 0.845 0.155
C15 Malignant neoplasm of oesophagus
0.000 0.846 0.154
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.847 0.153
E32 Diseases of thymus
0.000 0.847 0.153
E30 Disorders of puberty, not elsewhere classified
0.000 0.847 0.153
E56.1 Deficiency of vitamin K
0.000 0.847 0.152
E25 Adrenogenital disorders
0.000 0.848 0.152
E28 Ovarian dysfunction
0.000 0.848 0.152
E31 Polyglandular dysfunction
0.000 0.850 0.150
E55.9 Vitamin D deficiency, unspecified
0.000 0.850 0.150
E24.2 Drug-induced Cushing's syndrome
0.000 0.855 0.145
E24.8 Other Cushing's syndrome
0.000 0.862 0.138
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.862 0.138
E24.3 Ectopic ACTH syndrome
0.000 0.862 0.138
E24.1 Nelson's syndrome
0.000 0.862 0.138
C15.4 Middle third of oesophagus
0.000 0.862 0.138
C15.5 Lower third of oesophagus
0.000 0.864 0.136
C25 Malignant neoplasm of pancreas
0.000 0.864 0.136
E61.9 Deficiency of nutrient element, unspecified
0.000 0.864 0.136
E61.8 Deficiency of other specified nutrient elements
0.000 0.864 0.136
E61.7 Deficiency of multiple nutrient elements
0.000 0.864 0.136
E61.6 Vanadium deficiency
0.000 0.864 0.136
E61.5 Molybdenum deficiency
0.000 0.864 0.136
E61.4 Chromium deficiency
0.000 0.864 0.136
E61.3 Manganese deficiency
0.000 0.864 0.136
E61.0 Copper deficiency
0.000 0.864 0.136
E34 Other endocrine disorders
0.000 0.868 0.132
E53.9 Vitamin B deficiency, unspecified
0.000 0.868 0.132
E29 Testicular dysfunction
0.000 0.868 0.132
E14.9 Without complications
0.000 0.869 0.131
E21.2 Other hyperparathyroidism
0.000 0.870 0.130
C15.9 Oesophagus, unspecified
0.000 0.870 0.130
E21.4 Other specified disorders of parathyroid gland
0.000 0.870 0.130
I83.0 Varicose veins of lower extremities with ulcer
0.127 0.873 0.000
E83.3 Disorders of phosphorus metabolism
0.118 0.873 0.009
E83.8 Other disorders of mineral metabolism
0.102 0.874 0.023
E83.2 Disorders of zinc metabolism
0.102 0.874 0.023
E83.0 Disorders of copper metabolism
0.102 0.874 0.023
E61.2 Magnesium deficiency
0.000 0.874 0.125
E53.1 Pyridoxine deficiency
0.000 0.875 0.125
E53.0 Riboflavin deficiency
0.000 0.875 0.125
E83.9 Disorder of mineral metabolism, unspecified
0.102 0.875 0.022
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.879 0.121
E20.9 Hypoparathyroidism, unspecified
0.000 0.880 0.120
C15.0 Cervical part of oesophagus
0.000 0.881 0.119
C17 Malignant neoplasm of small intestine
0.000 0.881 0.119
E70-E90 Metabolic disorders
0.001 0.883 0.115
E21.0 Primary hyperparathyroidism
0.000 0.884 0.116
C15.3 Upper third of oesophagus
0.000 0.884 0.116
C25.2 Tail of pancreas
0.000 0.886 0.114
E20.8 Other hypoparathyroidism
0.000 0.886 0.114
E20.1 Pseudohypoparathyroidism
0.000 0.886 0.114
E20.0 Idiopathic hypoparathyroidism
0.000 0.886 0.114
E28.2 Polycystic ovarian syndrome
0.000 0.886 0.114
C17.0 Duodenum
0.000 0.887 0.113
C25.1 Body of pancreas
0.000 0.887 0.113
C25.3 Pancreatic duct
0.000 0.887 0.113
C15.1 Thoracic part of oesophagus
0.000 0.888 0.112
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.889 0.111
C15.8 Overlapping lesion of oesophagus
0.000 0.889 0.111
C15.2 Abdominal part of oesophagus
0.000 0.889 0.111
E30.9 Disorder of puberty, unspecified
0.000 0.890 0.110
E30.8 Other disorders of puberty
0.000 0.890 0.110
E30.1 Precocious puberty
0.000 0.890 0.110
E30.0 Delayed puberty
0.000 0.890 0.110
E32.9 Disease of thymus, unspecified
0.000 0.890 0.110
E32.8 Other diseases of thymus
0.000 0.890 0.110
E32.1 Abscess of thymus
0.000 0.890 0.110
E32.0 Persistent hyperplasia of thymus
0.000 0.890 0.110
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.890 0.110
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.890 0.110
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.890 0.110
E25.9 Adrenogenital disorder, unspecified
0.000 0.891 0.109
E25.8 Other adrenogenital disorders
0.000 0.891 0.109
E28.9 Ovarian dysfunction, unspecified
0.000 0.891 0.109
E28.8 Other ovarian dysfunction
0.000 0.891 0.109
E28.1 Androgen excess
0.000 0.891 0.109
E28.0 Oestrogen excess
0.000 0.891 0.109
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.891 0.109
C25.4 Endocrine pancreas
0.000 0.891 0.109
E78.2 Mixed hyperlipidaemia
0.000 0.891 0.109
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.892 0.108
E03.9 Hypothyroidism, unspecified
0.000 0.892 0.108
E31.9 Polyglandular dysfunction, unspecified
0.000 0.892 0.108
E31.8 Other polyglandular dysfunction
0.000 0.892 0.108
E31.1 Polyglandular hyperfunction
0.000 0.892 0.108
I73 Other peripheral vascular diseases
0.000 0.892 0.108
I73.9 Peripheral vascular disease, unspecified
0.000 0.892 0.108
I77 Other disorders of arteries and arterioles
0.000 0.893 0.107
C25.8 Overlapping lesion of pancreas
0.000 0.894 0.106
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.894 0.106
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.895 0.105
E31.0 Autoimmune polyglandular failure
0.000 0.895 0.105
C21 Malignant neoplasm of anus and anal canal
0.000 0.896 0.104
E28.3 Primary ovarian failure
0.000 0.897 0.103
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.898 0.102
I77.6 Arteritis, unspecified
0.000 0.899 0.101
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.100 0.899 0.000
E26 Hyperaldosteronism
0.001 0.902 0.097
E78.1 Pure hyperglyceridaemia
0.000 0.903 0.097
I74 Arterial embolism and thrombosis
0.000 0.903 0.097
E61.1 Iron deficiency
0.000 0.904 0.096
E34.3 Short stature, not elsewhere classified
0.000 0.904 0.096
C24.0 Extrahepatic bile duct
0.000 0.904 0.096
E11.3 With ophthalmic complications
0.000 0.905 0.095
E34.5 Androgen resistance syndrome
0.000 0.905 0.095
E34.4 Constitutional tall stature
0.000 0.905 0.095
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.905 0.095
E34.1 Other hypersecretion of intestinal hormones
0.000 0.905 0.095
E29.8 Other testicular dysfunction
0.000 0.905 0.095
E29.0 Testicular hyperfunction
0.000 0.905 0.095
E34.9 Endocrine disorder, unspecified
0.000 0.906 0.094
I72 Other aneurysm
0.000 0.907 0.093
E34.8 Other specified endocrine disorders
0.000 0.907 0.093
C25.9 Pancreas, unspecified
0.000 0.908 0.092
E29.9 Testicular dysfunction, unspecified
0.000 0.908 0.092
I73.0 Raynaud's syndrome
0.000 0.908 0.092
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.909 0.090
I77.8 Other specified disorders of arteries and arterioles
0.000 0.909 0.091
E78.5 Hyperlipidaemia, unspecified
0.000 0.909 0.091
I74.5 Embolism and thrombosis of iliac artery
0.000 0.909 0.091
E78.6 Lipoprotein deficiency
0.000 0.910 0.090
E88 Other metabolic disorders
0.000 0.910 0.089
E74 Other disorders of carbohydrate metabolism
0.001 0.911 0.088
C25.7 Other parts of pancreas
0.000 0.911 0.088
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.911 0.089
M45 Ankylosing spondylitis
0.086 0.914 0.000
C17.8 Overlapping lesion of small intestine
0.000 0.915 0.085
C17.3 Meckel's diverticulum
0.000 0.915 0.085
E84 Cystic fibrosis
0.001 0.915 0.084
I70 Atherosclerosis
0.000 0.916 0.084
E78.3 Hyperchylomicronaemia
0.000 0.916 0.084
E77 Disorders of glycoprotein metabolism
0.001 0.916 0.083
E76 Disorders of glycosaminoglycan metabolism
0.001 0.916 0.083
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.916 0.083
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.916 0.083
E22 Hyperfunction of pituitary gland
0.000 0.917 0.083
E85 Amyloidosis
0.001 0.917 0.082
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.917 0.083
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.917 0.083
E11.4 With neurological complications
0.000 0.917 0.083
E73 Lactose intolerance
0.001 0.917 0.082
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.918 0.082
I73.8 Other specified peripheral vascular diseases
0.000 0.918 0.082
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.918 0.082
C23 Malignant neoplasm of gallbladder
0.000 0.918 0.081
I77.3 Arterial fibromuscular dysplasia
0.000 0.919 0.081
E79 Disorders of purine and pyrimidine metabolism
0.001 0.919 0.080
E23 Hypofunction and other disorders of pituitary gland
0.000 0.919 0.081
I72.4 Aneurysm of artery of lower extremity
0.000 0.920 0.080
E70 Disorders of aromatic amino-acid metabolism
0.001 0.920 0.079
C24.8 Overlapping lesion of biliary tract
0.000 0.921 0.078
E34.0 Carcinoid syndrome
0.000 0.922 0.078
I77.2 Rupture of artery
0.000 0.923 0.077
I72.3 Aneurysm of iliac artery
0.000 0.923 0.077
E29.1 Testicular hypofunction
0.000 0.923 0.077
I77.5 Necrosis of artery
0.000 0.923 0.077
I77.4 Coeliac artery compression syndrome
0.000 0.923 0.077
I77.1 Stricture of artery
0.000 0.923 0.077
E72 Other disorders of amino-acid metabolism
0.001 0.924 0.075
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.924 0.076
C17.1 Jejunum
0.000 0.924 0.076
E88.9 Metabolic disorder, unspecified
0.000 0.924 0.075
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.925 0.075
C21.2 Cloacogenic zone
0.000 0.925 0.074
C24.9 Biliary tract, unspecified
0.000 0.926 0.074
I72.0 Aneurysm of carotid artery
0.000 0.927 0.073
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.927 0.072
E75.5 Other lipid storage disorders
0.001 0.928 0.072
I72.1 Aneurysm of artery of upper extremity
0.000 0.928 0.072
E78.4 Other hyperlipidaemia
0.000 0.929 0.071
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.929 0.070
E26.8 Other hyperaldosteronism
0.001 0.930 0.070
E26.1 Secondary hyperaldosteronism
0.001 0.930 0.070
E88.2 Lipomatosis, not elsewhere classified
0.000 0.930 0.070
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.931 0.069
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.931 0.068
E23.7 Disorder of pituitary gland, unspecified
0.000 0.932 0.068
E85.4 Organ-limited amyloidosis
0.000 0.932 0.068
I83.1 Varicose veins of lower extremities with inflammation
0.068 0.932 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.933 0.067
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.933 0.067
M45.X6 Ankylosing spondylitis (Lumbar region)
0.067 0.933 0.000
E75.2 Other sphingolipidosis
0.001 0.933 0.066
C21.0 Anus, unspecified
0.000 0.933 0.066
M45.X2 Ankylosing spondylitis (Cervical region)
0.066 0.934 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.934 0.066
I72.9 Aneurysm of unspecified site
0.000 0.934 0.066
E75.6 Lipid storage disorder, unspecified
0.001 0.934 0.065
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.934 0.065
E75.3 Sphingolipidosis, unspecified
0.001 0.934 0.065
E75.1 Other gangliosidosis
0.001 0.934 0.065
E75.0 GM2 gangliosidosis
0.001 0.934 0.065
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.936 0.063
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.936 0.063
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.936 0.063
E74.2 Disorders of galactose metabolism
0.001 0.936 0.063
E74.1 Disorders of fructose metabolism
0.001 0.936 0.063
I70.8 Atherosclerosis of other arteries
0.000 0.936 0.064
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.937 0.063
I70.1 Atherosclerosis of renal artery
0.000 0.937 0.063
C21.1 Anal canal
0.000 0.937 0.062
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.937 0.062
E85.3 Secondary systemic amyloidosis
0.001 0.938 0.062
E74.0 Glycogen storage disease
0.001 0.938 0.061
E83.4 Disorders of magnesium metabolism
0.048 0.938 0.014
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.938 0.061
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.062 0.938 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.062 0.938 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.062 0.938 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.062 0.938 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.062 0.938 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.062 0.938 0.000
E26.9 Hyperaldosteronism, unspecified
0.001 0.938 0.061
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.939 0.061
I72.2 Aneurysm of renal artery
0.000 0.939 0.061
I70.0 Atherosclerosis of aorta
0.000 0.939 0.061
E84.8 Cystic fibrosis with other manifestations
0.001 0.939 0.060
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.939 0.060
E71.3 Disorders of fatty-acid metabolism
0.001 0.939 0.060
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.939 0.060
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.939 0.060
E71.0 Maple-syrup-urine disease
0.001 0.939 0.060
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.939 0.060
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.939 0.060
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.939 0.060
E76.2 Other mucopolysaccharidoses
0.001 0.939 0.060
E76.1 Mucopolysaccharidosis, type II
0.001 0.939 0.060
E76.0 Mucopolysaccharidosis, type I
0.001 0.939 0.060
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.939 0.060
E77.8 Other disorders of glycoprotein metabolism
0.001 0.939 0.060
E77.1 Defects in glycoprotein degradation
0.001 0.939 0.060
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.939 0.060
E88.8 Other specified metabolic disorders
0.000 0.939 0.060
E84.9 Cystic fibrosis, unspecified
0.001 0.940 0.059
E85.8 Other amyloidosis
0.001 0.940 0.059
E22.8 Other hyperfunction of pituitary gland
0.000 0.940 0.060
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.940 0.059
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.940 0.059
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.940 0.059
E73.8 Other lactose intolerance
0.001 0.940 0.059
E73.1 Secondary lactase deficiency
0.001 0.940 0.059
E73.0 Congenital lactase deficiency
0.001 0.940 0.059
I70.9 Generalised and unspecified atherosclerosis
0.000 0.941 0.059
I79.1 Aortitis in diseases classified elsewhere
0.000 0.941 0.059
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.941 0.059
I72.8 Aneurysm of other specified arteries
0.000 0.941 0.058
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.942 0.057
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.942 0.057
E79.1 Lesch-Nyhan syndrome
0.001 0.942 0.057
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.942 0.058
E23.1 Drug-induced hypopituitarism
0.000 0.942 0.058
E73.9 Lactose intolerance, unspecified
0.001 0.942 0.057
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.942 0.058
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.943 0.056
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.943 0.056
E70.2 Disorders of tyrosine metabolism
0.001 0.943 0.056
E70.1 Other hyperphenylalaninaemias
0.001 0.943 0.056
E70.0 Classical phenylketonuria
0.001 0.943 0.056
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.943 0.056
E22.1 Hyperprolactinaemia
0.000 0.944 0.056
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.944 0.056
C17.9 Small intestine, unspecified
0.000 0.944 0.055
C17.2 Ileum
0.000 0.945 0.055
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.945 0.054
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.945 0.054
E72.5 Disorders of glycine metabolism
0.001 0.945 0.054
E72.4 Disorders of ornithine metabolism
0.001 0.945 0.054
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.945 0.054
E72.2 Disorders of urea cycle metabolism
0.001 0.945 0.054
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.945 0.054
I78 Diseases of capillaries
0.000 0.945 0.055
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.054 0.946 0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.946 0.054
E72.0 Disorders of amino-acid transport
0.001 0.947 0.052
E70.3 Albinism
0.001 0.947 0.052
E88.3 Tumour lysis syndrome
0.001 0.947 0.052
E78.8 Other disorders of lipoprotein metabolism
0.000 0.950 0.050
C26.8 Overlapping lesion of digestive system
0.000 0.950 0.050
C26.1 Spleen
0.000 0.950 0.050
I77.0 Arteriovenous fistula, acquired
0.000 0.950 0.050
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.950 0.048
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.951 0.049
E04 Other non-toxic goitre
0.003 0.951 0.046
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.951 0.049
E78.0 Pure hypercholesterolaemia
0.000 0.953 0.047
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.953 0.047
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.953 0.047
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.954 0.046
C22.7 Other specified carcinomas of liver
0.000 0.954 0.045
C22.4 Other sarcomas of liver
0.000 0.954 0.045
C22.3 Angiosarcoma of liver
0.000 0.954 0.045
C22.2 Hepatoblastoma
0.000 0.954 0.045
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.955 0.045
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.955 0.044
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.956 0.044
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.956 0.044
E23.6 Other disorders of pituitary gland
0.000 0.956 0.043
C22.9 Liver, unspecified
0.000 0.957 0.043
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.957 0.043
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.957 0.042
C24.1 Ampulla of Vater
0.001 0.958 0.042
E22.0 Acromegaly and pituitary gigantism
0.000 0.958 0.042
C25.0 Head of pancreas
0.000 0.958 0.042
C22.1 Intrahepatic bile duct carcinoma
0.000 0.959 0.041
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.959 0.041
I74.8 Embolism and thrombosis of other arteries
0.000 0.960 0.039
E85.9 Amyloidosis, unspecified
0.001 0.960 0.039
E23.2 Diabetes insipidus
0.000 0.960 0.039
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.961 0.039
R31 Unspecified haematuria
0.037 0.963 0.000
I78.8 Other diseases of capillaries
0.000 0.964 0.036

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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