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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2213580
log Bayes Factor = 254.152
Chromosome 6   position 32,388,574  (GRCh37) Explore rs2213580 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
E10.1 With ketoacidosis
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
R31 Unspecified haematuria
0.000 0.000 1.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M15-M19 Arthrosis
1.000 0.000 0.000
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
E14 Unspecified diabetes mellitus
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
K90 Intestinal malabsorption
1.000 0.000 0.000
M18 Arthrosis of first carpometacarpal joint
1.000 0.000 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
1.000 0.000 0.000
M35 Other systemic involvement of connective tissue
1.000 0.000 0.000
H36.0 Diabetic retinopathy
1.000 0.000 0.000
M35.0 Sicca syndrome [Sjogren]
0.999 0.001 0.000
D60-D64 Aplastic and other anaemias
0.999 0.001 0.000
M06 Other rheumatoid arthritis
0.000 0.001 0.999
D64 Other anaemias
0.998 0.002 0.000
E20-E35 Disorders of other endocrine glands
0.998 0.002 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.997 0.003 0.000
M17 Gonarthrosis [arthrosis of knee]
0.997 0.003 0.000
D64.9 Anaemia, unspecified
0.997 0.003 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.003 0.997
M17.1 Other primary gonarthrosis
0.997 0.003 0.000
M05-M14 Inflammatory polyarthropathies
0.003 0.004 0.994
D69 Purpura and other haemorrhagic conditions
0.996 0.004 0.000
M05 Seropositive rheumatoid arthritis
0.001 0.004 0.995
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.005 0.995
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.995 0.005 0.000
E27 Other disorders of adrenal gland
0.995 0.005 0.000
E27.1 Primary adrenocortical insufficiency
0.994 0.006 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.994 0.006 0.000
K90.9 Intestinal malabsorption, unspecified
0.992 0.008 0.000
D80-D89 Certain disorders involving the immune mechanism
0.992 0.008 0.000
Chapter VI Diseases of the nervous system
0.991 0.009 0.000
E10.2 With renal complications
0.991 0.009 0.000
E14.3 With ophthalmic complications
0.991 0.009 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.990 0.009 0.000
E14.9 Without complications
0.989 0.011 0.000
D69.6 Thrombocytopenia, unspecified
0.989 0.011 0.000
C91 Lymphoid leukaemia
0.988 0.012 0.000
E10.4 With neurological complications
0.986 0.014 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.985 0.015 0.000
G56 Mononeuropathies of upper limb
0.985 0.015 0.000
K90-K93 Other diseases of the digestive system
0.985 0.015 0.000
Chapter XI Diseases of the digestive system
0.984 0.016 0.000
D50-D53 Nutritional anaemias
0.984 0.016 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.982 0.018 0.000
G56.0 Carpal tunnel syndrome
0.982 0.018 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.982 0.018 0.000
M24 Other specific joint derangements
0.981 0.019 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.981 0.019 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.981 0.019 0.000
H00.1 Chalazion
0.000 0.019 0.981
C91.1 Chronic lymphocytic leukaemia
0.980 0.020 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.022 0.978
H06.2 Dysthyroid exophthalmos
0.977 0.023 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.976 0.024 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.026 0.974
D50 Iron deficiency anaemia
0.973 0.027 0.000
D50.9 Iron deficiency anaemia, unspecified
0.972 0.028 0.000
K70-K77 Diseases of liver
0.970 0.030 0.000
E89.0 Postprocedural hypothyroidism
0.970 0.030 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.970 0.030 0.000
C81 Hodgkin's disease
0.968 0.032 0.000
M24.1 Other articular cartilage disorders
0.968 0.032 0.000
K75 Other inflammatory liver diseases
0.967 0.033 0.000
M60-M63 Disorders of muscles
0.963 0.037 0.000
H33 Retinal detachments and breaks
0.963 0.037 0.000
K75.4 Autoimmune hepatitis
0.963 0.037 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.962 0.038 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.961 0.039 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.960 0.040 0.000
E70-E90 Metabolic disorders
0.960 0.040 0.000
H33.3 Retinal breaks without detachment
0.952 0.048 0.000
Chapter II Neoplasms
0.949 0.051 0.000
K50-K52 Noninfective enteritis and colitis
0.565 0.064 0.371
Chapter XII Diseases of the skin and subcutaneous tissue
0.934 0.066 0.000
M06.3 Rheumatoid nodule
0.000 0.067 0.933
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.933 0.067 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.932 0.068 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.930 0.070 0.000
H05 Disorders of orbit
0.928 0.072 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.073 0.927
D86 Sarcoidosis
0.927 0.073 0.000
D69.4 Other primary thrombocytopenia
0.923 0.077 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.923 0.077 0.000
M32 Systemic lupus erythematosus
0.922 0.078 0.000
C83.3 Large cell (diffuse)
0.921 0.079 0.000
H34 Retinal vascular occlusions
0.919 0.081 0.000
L50-L54 Urticaria and erythema
0.916 0.084 0.000
K73 Chronic hepatitis, not elsewhere classified
0.914 0.086 0.000
E40-E46 Malnutrition
0.911 0.089 0.000
C85.1 B-cell lymphoma, unspecified
0.910 0.090 0.000
M86-M90 Other osteopathies
0.909 0.091 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.904 0.096 0.000
L10-L14 Bullous disorders
0.903 0.097 0.000
E50-E64 Other nutritional deficiencies
0.899 0.101 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.899 0.101 0.000
C81.9 Hodgkin's disease, unspecified
0.897 0.103 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.895 0.105 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.894 0.106 0.000
D86.9 Sarcoidosis, unspecified
0.893 0.107 0.000
D80 Immunodeficiency with predominantly antibody defects
0.893 0.107 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.892 0.108 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.890 0.110 0.000
K75.8 Other specified inflammatory liver diseases
0.888 0.112 0.000
M60 Myositis
0.887 0.113 0.000
L13 Other bullous disorders
0.886 0.114 0.000
H43-H45 Disorders of vitreous body and globe
0.886 0.114 0.000
M34 Systemic sclerosis
0.884 0.116 0.000
E14.1 With ketoacidosis
0.878 0.122 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.878 0.122 0.000
E28 Ovarian dysfunction
0.876 0.124 0.000
L13.0 Dermatitis herpetiformis
0.875 0.125 0.000
G11 Hereditary ataxia
0.873 0.127 0.000
G59.0 Diabetic mononeuropathy
0.872 0.128 0.000
E14.8 With unspecified complications
0.872 0.128 0.000
M35.1 Other overlap syndromes
0.871 0.129 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.871 0.129 0.000
M86 Osteomyelitis
0.871 0.129 0.000
C34 Malignant neoplasm of bronchus and lung
0.871 0.129 0.000
M62 Other disorders of muscle
0.870 0.130 0.000
E10.0 With coma
0.869 0.131 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.869 0.131 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.866 0.134 0.000
M06.34 Rheumatoid nodule (Hand)
0.000 0.135 0.865
H05.2 Exophthalmic conditions
0.862 0.138 0.000
M15 Polyarthrosis
0.861 0.139 0.000
L53 Other erythematous conditions
0.860 0.140 0.000
Q43 Other congenital malformations of intestine
0.859 0.141 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.142 0.858
E07 Other disorders of thyroid
0.858 0.142 0.000
E10.5 With peripheral circulatory complications
0.857 0.143 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.856 0.144 0.000
G51 Facial nerve disorders
0.856 0.144 0.000
M24.5 Contracture of joint
0.854 0.146 0.000
D61 Other aplastic anaemias
0.854 0.146 0.000
M35.7 Hypermobility syndrome
0.854 0.146 0.000
H43 Disorders of vitreous body
0.852 0.148 0.000
C34.3 Lower lobe, bronchus or lung
0.850 0.150 0.000
L52 Erythema nodosum
0.850 0.150 0.000
Chapter VIII Diseases of the ear and mastoid process
0.850 0.150 0.000
C81.1 Nodular sclerosis
0.850 0.150 0.000
H34.8 Other retinal vascular occlusions
0.850 0.150 0.000
E46 Unspecified protein-energy malnutrition
0.848 0.152 0.000
E10.8 With unspecified complications
0.848 0.152 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.846 0.154 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.846 0.154 0.000
C88 Malignant immunoproliferative diseases
0.843 0.157 0.000
M21 Other acquired deformities of limbs
0.842 0.158 0.000
H00 Hordeolum and chalazion
0.155 0.159 0.687
K35-K38 Diseases of appendix
0.840 0.160 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.839 0.161 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.835 0.165 0.000
C91.9 Lymphoid leukaemia, unspecified
0.832 0.168 0.000
E22 Hyperfunction of pituitary gland
0.832 0.168 0.000
D64.8 Other specified anaemias
0.832 0.168 0.000
H04 Disorders of lachrymal system
0.831 0.169 0.000
H35 Other retinal disorders
0.828 0.172 0.000
G11.9 Hereditary ataxia, unspecified
0.826 0.174 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.174 0.826
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.824 0.176 0.000
C07 Malignant neoplasm of parotid gland
0.817 0.183 0.000
C83.7 Burkitt's tumour
0.816 0.184 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.184 0.816
D83 Common variable immunodeficiency
0.815 0.185 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.815 0.185 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.185 0.815
Q60-Q64 Congenital malformations of the urinary system
0.814 0.186 0.000
E10.7 With multiple complications
0.812 0.188 0.000
D86.3 Sarcoidosis of skin
0.811 0.189 0.000
M60.9 Myositis, unspecified
0.811 0.189 0.000
D62 Acute posthaemorrhagic anaemia
0.810 0.190 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.806 0.194 0.000
K35.9 Acute appendicitis, unspecified
0.805 0.195 0.000
D69.5 Secondary thrombocytopenia
0.805 0.195 0.000
K35 Acute appendicitis
0.804 0.196 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.804 0.196 0.000
G54 Nerve root and plexus disorders
0.804 0.196 0.000
M00-M03 Infectious arthropathies
0.802 0.197 0.000
M86.9 Osteomyelitis, unspecified
0.802 0.198 0.000
E07.8 Other specified disorders of thyroid
0.802 0.198 0.000
E53 Deficiency of other B group vitamins
0.801 0.199 0.000
D69.2 Other nonthrombocytopenic purpura
0.801 0.199 0.000
M21.0 Valgus deformity, not elsewhere classified
0.800 0.200 0.000
C84.5 Other and unspecified T-cell lymphomas
0.799 0.201 0.000
H33.1 Retinoschisis and retinal cysts
0.798 0.202 0.000
H43.8 Other disorders of vitreous body
0.795 0.205 0.000
H60-H62 Diseases of external ear
0.793 0.207 0.000
E14.2 Withrenal complications
0.791 0.209 0.000
E06 Thyroiditis
0.788 0.212 0.000
H80-H83 Diseases of inner ear
0.786 0.214 0.000
H33.4 Traction detachment of retina
0.785 0.215 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.216 0.784
G30-G32 Other degenerative diseases of the nervous system
0.784 0.216 0.000
C04 Malignant neoplasm of floor of mouth
0.783 0.217 0.000
C81.2 Mixed cellularity
0.781 0.219 0.000
E31 Polyglandular dysfunction
0.780 0.220 0.000
G56.4 Causalgia
0.778 0.222 0.000
H04.8 Other disorders of lachrymal system
0.777 0.223 0.000
C34.0 Main bronchus
0.776 0.224 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.775 0.225 0.000
G51.0 Bell's palsy
0.774 0.226 0.000
L53.9 Erythematous condition, unspecified
0.773 0.227 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.773 0.227 0.000
M62.8 Other specified disorders of muscle
0.771 0.229 0.000
C83.0 Small cell (diffuse)
0.771 0.229 0.000
H61 Other disorders of external ear
0.768 0.232 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.768 0.232 0.000
D55-D59 Haemolytic anaemias
0.768 0.232 0.000
Q43.9 Congenital malformation of intestine, unspecified
0.766 0.234 0.000
M80-M85 Disorders of bone density and structure
0.764 0.236 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.762 0.238 0.000
K73.9 Chronic hepatitis, unspecified
0.760 0.240 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.759 0.241 0.000
H30 Chorioretinal inflammation
0.759 0.241 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.242 0.758
Q44.6 Cystic disease of liver
0.758 0.242 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.756 0.244 0.000
H35.4 Peripheral retinal degeneration
0.756 0.244 0.000
G52 Disorders of other cranial nerves
0.755 0.245 0.000
E53.8 Deficiency of other specified B group vitamins
0.755 0.245 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.754 0.246 0.000
M86.8 Other osteomyelitis
0.753 0.247 0.000
D73 Diseases of spleen
0.752 0.248 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.751 0.249 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.750 0.250 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.250 0.750
D80.1 Nonfamilial hypogammaglobulinaemia
0.749 0.251 0.000
M11 Other crystal arthropathies
0.002 0.251 0.747
G12 Spinal muscular atrophy and related syndromes
0.748 0.252 0.000
C91.5 Adult T-cell leukaemia
0.747 0.253 0.000
C83.1 Small cleaved cell (diffuse)
0.746 0.253 0.000
E14.5 With peripheral circulatory complications
0.746 0.254 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.744 0.256 0.000
E73 Lactose intolerance
0.742 0.257 0.000
M17.5 Other secondary gonarthrosis
0.742 0.258 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.259 0.741
M17.4 Other secondary gonarthrosis, bilateral
0.739 0.261 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.737 0.263 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.736 0.264 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.736 0.264 0.000
E28.2 Polycystic ovarian syndrome
0.733 0.267 0.000
H83 Other diseases of inner ear
0.732 0.268 0.000
D52 Folate deficiency anaemia
0.731 0.269 0.000
G70-G73 Diseases of myoneural junction and muscle
0.731 0.269 0.000
L53.0 Toxic erythema
0.730 0.270 0.000
H43.1 Vitreous haemorrhage
0.730 0.270 0.000
M34.0 Progressive systemic sclerosis
0.729 0.271 0.000
M14 Arthropathies in other diseases classified elsewhere
0.002 0.271 0.727
H05.0 Acute inflammation of orbit
0.729 0.271 0.000
K90.8 Other intestinal malabsorption
0.729 0.271 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.726 0.274 0.000
C84.8 Cutaneous T-cell lymphoma, unspecified
0.726 0.274 0.000
M24.51 Contracture of joint (Shoulder region)
0.725 0.275 0.000
E28.3 Primary ovarian failure
0.725 0.275 0.000
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.724 0.276 0.000
D82 Immunodeficiency associated with other major defects
0.723 0.277 0.000
M15.2 Bouchard's nodes (with arthropathy)
0.723 0.277 0.000
D61.9 Aplastic anaemia, unspecified
0.722 0.278 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.721 0.279 0.000
M35.2 Behcet's disease
0.721 0.279 0.000
H10-H13 Disorders of conjunctiva
0.720 0.280 0.000
M24.7 Protrusio acetabuli
0.719 0.281 0.000
Q00-Q07 Congenital malformations of the nervous system
0.719 0.281 0.000
H34.2 Other retinal artery occlusions
0.718 0.282 0.000
M23 Internal derangement of knee
0.718 0.282 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.718 0.282 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
E14.7 With multiple complications
0.717 0.283 0.000
E14.0 With coma
0.717 0.283 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.717 0.283 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.717 0.283 0.000
E16.4 Abnormal secretion of gastrin
0.717 0.283 0.000
E16.3 Increased secretion of glucagon
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
K90.3 Pancreatic steatorrhoea
0.717 0.283 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.717 0.283 0.000
K90.1 Tropical sprue
0.717 0.283 0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.717 0.283 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.717 0.283 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.717 0.283 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.717 0.283 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.717 0.283 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.717 0.283 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.717 0.283 0.000
M35.5 Multifocal fibrosclerosis
0.717 0.283 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.717 0.283 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.716 0.283 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.284 0.716
M06.2 Rheumatoid bursitis
0.000 0.284 0.716
M06.1 Adult-onset Still's disease
0.000 0.284 0.716
D64.4 Congenital dyserythropoietic anaemia
0.716 0.284 0.000
D64.3 Other sideroblastic anaemias
0.716 0.284 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.716 0.284 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.716 0.284 0.000
D64.0 Hereditary sideroblastic anaemia
0.716 0.284 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.284 0.716
E35 Disorders of endocrine glands in diseases classified elsewhere
0.715 0.284 0.000
E32 Diseases of thymus
0.715 0.284 0.000
E30 Disorders of puberty, not elsewhere classified
0.715 0.284 0.000
E25 Adrenogenital disorders
0.715 0.284 0.000
D67 Hereditary factor IX deficiency
0.715 0.285 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.715 0.285 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.285 0.715
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.285 0.715
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.285 0.715
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.285 0.715
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.285 0.715
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.285 0.715
N08 Glomerular disorders in diseases classified elsewhere
0.715 0.285 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.002 0.286 0.712
M08 Juvenile arthritis
0.002 0.286 0.712
D69.8 Other specified haemorrhagic conditions
0.714 0.286 0.000
D69.1 Qualitative platelet defects
0.714 0.286 0.000
M05.8 Other seropositive rheumatoid arthritis
0.001 0.286 0.713
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.001 0.286 0.713
M05.2 Rheumatoid vasculitis
0.001 0.286 0.713
M05.1 Rheumatoid lung disease
0.001 0.286 0.713
M05.0 Felty's syndrome
0.001 0.286 0.713
N08.3 Glomerular disorders in diabetes mellitus
0.714 0.286 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.713 0.286 0.000
C94 Other leukaemias of specified cell type
0.713 0.286 0.000
C86 Other specified types of T/NK-cell lymphoma
0.713 0.286 0.000
H43.9 Disorder of vitreous body, unspecified
0.713 0.287 0.000
E27.5 Adrenomedullary hyperfunction
0.713 0.287 0.000
E27.0 Other adrenocortical overactivity
0.713 0.287 0.000
C81.0 Lymphocytic predominance
0.713 0.287 0.000
N00-N08 Glomerular diseases
0.713 0.287 0.000
D81 Combined immunodeficiencies
0.711 0.289 0.000
M34.8 Other forms of systemic sclerosis
0.710 0.290 0.000
E24 Cushing's syndrome
0.710 0.290 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.710 0.290 0.000
Q35-Q37 Cleft lip and cleft palate
0.709 0.290 0.000
D53 Other nutritional anaemias
0.709 0.291 0.000
Q43.3 Congenital malformations of intestinal fixation
0.709 0.291 0.000
N04 Nephrotic syndrome
0.709 0.291 0.000
C91.0 Acute lymphoblastic leukaemia
0.709 0.291 0.000
E16.1 Other hypoglycaemia
0.709 0.291 0.000
C91.8 Mature B-cell leukaemia Burkitt-type
0.709 0.291 0.000
C91.7 Other lymphoid leukaemia
0.709 0.291 0.000
C91.6 Prolymphocytic leukaemia of T-cell type
0.709 0.291 0.000
C91.3 Prolymphocytic leukaemia
0.709 0.291 0.000
C91.2 Subacute lymphocytic leukaemia
0.709 0.291 0.000
E10.6 With other specified complications
0.707 0.293 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.706 0.294 0.000
M60.0 Infective myositis
0.705 0.295 0.000
H06.3 Other disorders of orbit in diseases classified elsewhere
0.704 0.296 0.000
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.704 0.296 0.000
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.704 0.296 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.704 0.296 0.000
E29 Testicular dysfunction
0.704 0.296 0.000
H83.0 Labyrinthitis
0.704 0.296 0.000
M24.9 Joint derangement, unspecified
0.704 0.296 0.000
M65-M68 Disorders of synovium and tendon
0.703 0.297 0.000
N04.9 Unspecified
0.703 0.297 0.000
E14.6 With other specified complications
0.703 0.297 0.000
E78.2 Mixed hyperlipidaemia
0.702 0.298 0.000
C08 Malignant neoplasm of other and unspecified major salivary glands
0.701 0.299 0.000
C34.2 Middle lobe, bronchus or lung
0.701 0.299 0.000
E23 Hypofunction and other disorders of pituitary gland
0.700 0.300 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.300 0.700
D89.0 Polyclonal hypergammaglobulinaemia
0.700 0.300 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.700 0.300 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.700 0.300 0.000
C85.0 Lymphosarcoma
0.700 0.300 0.000
E14.4 With neurological complications
0.700 0.300 0.000
C34.8 Overlapping lesion of bronchus and lung
0.698 0.302 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.698 0.302 0.000
D50.1 Sideropenic dysphagia
0.697 0.302 0.000
G58 Other mononeuropathies
0.697 0.303 0.000
E51 Thiamine deficiency
0.696 0.304 0.000
H35.0 Background retinopathy and retinal vascular changes
0.696 0.304 0.000
K77 Liver disorders in diseases classified elsewhere
0.696 0.304 0.000
K71 Toxic liver disease
0.696 0.304 0.000
E03.8 Other specified hypothyroidism
0.694 0.305 0.000
C81.7 Other Hodgkin's disease
0.694 0.306 0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.694 0.306 0.000
C81.3 Lymphocytic depletion
0.694 0.306 0.000
E11 Non-insulin-dependent diabetes mellitus
0.694 0.306 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.694 0.306 0.000
M24.18 Other articular cartilage disorders (Other)
0.694 0.306 0.000
M24.14 Other articular cartilage disorders (Hand)
0.694 0.306 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.694 0.306 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.694 0.306 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.694 0.306 0.000
K75.2 Nonspecific reactive hepatitis
0.694 0.306 0.000
K75.1 Phlebitis of portal vein
0.694 0.306 0.000
M21.8 Other specified acquired deformities of limbs
0.694 0.306 0.000
H04.4 Chronic inflammation of lachrymal passages
0.693 0.307 0.000
E61 Deficiency of other nutrient elements
0.693 0.307 0.000
D70 Agranulocytosis
0.692 0.308 0.000
G11.1 Early-onset cerebellar ataxia
0.692 0.308 0.000
H05.8 Other disorders of orbit
0.692 0.308 0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.692 0.308 0.000
L50 Urticaria
0.691 0.309 0.000
H43.2 Crystalline deposits in vitreous body
0.691 0.309 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.691 0.309 0.000
M61 Calcification and ossification of muscle
0.691 0.309 0.000
D73.5 Infarction of spleen
0.691 0.309 0.000
H35.6 Retinal haemorrhage
0.691 0.309 0.000
H61.8 Other specified disorders of external ear
0.690 0.310 0.000
D83.9 Common variable immunodeficiency, unspecified
0.689 0.311 0.000
C83.6 Undifferentiated (diffuse)
0.689 0.311 0.000
C83.5 Lymphoblastic (diffuse)
0.689 0.311 0.000
C83.4 Immunoblastic (diffuse)
0.689 0.311 0.000
C83.2 Mixed small and large cell (diffuse)
0.689 0.311 0.000
M34.1 CR(E)ST syndrome
0.689 0.311 0.000
H61.0 Perichondritis of external ear
0.689 0.311 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.689 0.311 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.689 0.311 0.000
E89.5 Postprocedural testicular hypofunction
0.689 0.311 0.000
E89.4 Postprocedural ovarian failure
0.689 0.311 0.000
E89.1 Postprocedural hypoinsulinaemia
0.689 0.311 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.688 0.312 0.000
E84 Cystic fibrosis
0.688 0.312 0.000
E77 Disorders of glycoprotein metabolism
0.688 0.312 0.000
E76 Disorders of glycosaminoglycan metabolism
0.688 0.312 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.688 0.312 0.000
E72 Other disorders of amino-acid metabolism
0.688 0.312 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.688 0.312 0.000
E70 Disorders of aromatic amino-acid metabolism
0.688 0.312 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.688 0.312 0.000
E88 Other metabolic disorders
0.688 0.312 0.000
M86.96 Osteomyelitis, unspecified (Lower leg)
0.686 0.314 0.000
E74 Other disorders of carbohydrate metabolism
0.684 0.315 0.000
K52 Other non-infective gastro-enteritis and colitis
0.566 0.316 0.119
E34 Other endocrine disorders
0.683 0.317 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.682 0.318 0.000
M15.4 Erosive (osteo)arthrosis
0.681 0.319 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.681 0.319 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.320 0.680
Q38 Other congenital malformations of tongue, mouth and pharynx
0.680 0.320 0.000
C95 Leukaemia of unspecified cell type
0.679 0.320 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.679 0.321 0.000
G54.4 Lumbosacral root disorders, not elsewhere classified
0.678 0.321 0.000
Q40 Other congenital malformations of upper alimentary tract
0.678 0.322 0.000
H61.3 Acquired stenosis of external ear canal
0.677 0.323 0.000
C05 Malignant neoplasm of palate
0.677 0.323 0.000
C92 Myeloid leukaemia
0.676 0.324 0.000
C93 Monocytic leukaemia
0.675 0.325 0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.674 0.326 0.000
M86.86 Other osteomyelitis (Lower leg)
0.674 0.326 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.672 0.328 0.000
M88 Paget's disease of bone [osteitis deformans]
0.670 0.330 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.331 0.669
M06.38 Rheumatoid nodule (Other)
0.000 0.331 0.669
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.331 0.669
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.331 0.669
M06.33 Rheumatoid nodule (Forearm)
0.000 0.331 0.669
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.331 0.669
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.331 0.669
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.331 0.669
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.669 0.331 0.000
G14 Postpolio syndrome
0.669 0.331 0.000
G10 Huntington's disease
0.669 0.331 0.000
C06 Malignant neoplasm of other and unspecified parts of mouth
0.669 0.331 0.000
N05 Unspecified nephritic syndrome
0.668 0.332 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.668 0.332 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.333 0.667
M86.1 Other acute osteomyelitis
0.667 0.333 0.000
Q45 Other congenital malformations of digestive system
0.667 0.333 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.667 0.333 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.667 0.333 0.000
C04.0 Anterior floor of mouth
0.666 0.334 0.000
H05.9 Disorder of orbit, unspecified
0.665 0.335 0.000
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.665 0.335 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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