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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2284178
log Bayes Factor = 138.159
Chromosome 6   position 31,432,125  (GRCh37) Explore rs2284178 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.001 0.999
M45 Ankylosing spondylitis
0.999 0.001 0.000
E10.1 With ketoacidosis
0.000 0.002 0.998
E10.2 With renal complications
0.000 0.003 0.997
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.995 0.005 0.000
L40.9 Psoriasis, unspecified
0.995 0.005 0.000
H36.0 Diabetic retinopathy
0.000 0.006 0.994
E10.4 With neurological complications
0.000 0.011 0.989
E50-E64 Other nutritional deficiencies
0.000 0.019 0.981
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.021 0.979
G37 Other demyelinating diseases of central nervous system
0.000 0.026 0.974
E53 Deficiency of other B group vitamins
0.000 0.029 0.971
E14 Unspecified diabetes mellitus
0.000 0.032 0.968
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.034 0.966
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.041 0.959
M45.X2 Ankylosing spondylitis (Cervical region)
0.951 0.049 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.052 0.948
E14.3 With ophthalmic complications
0.000 0.062 0.938
E16 Other disorders of pancreatic internal secretion
0.000 0.071 0.929
E11 Non-insulin-dependent diabetes mellitus
0.000 0.087 0.913
E11.3 With ophthalmic complications
0.000 0.094 0.906
E16.2 Hypoglycaemia, unspecified
0.000 0.104 0.896
E06 Thyroiditis
0.000 0.107 0.893
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.110 0.890
E10.0 With coma
0.000 0.116 0.884
E53.9 Vitamin B deficiency, unspecified
0.000 0.117 0.883
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.155 0.845
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.166 0.834
E06.3 Autoimmune thyroiditis
0.000 0.171 0.829
E55 Vitamin D deficiency
0.000 0.178 0.822
E10.5 With peripheral circulatory complications
0.000 0.182 0.818
E40-E46 Malnutrition
0.000 0.192 0.808
E11.1 With ketoacidosis
0.000 0.194 0.806
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.799 0.201 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.206 0.794
E10.6 With other specified complications
0.000 0.213 0.787
H36 Retinal disorders in diseases classified elsewhere
0.000 0.214 0.786
E14.2 Withrenal complications
0.000 0.219 0.781
G36 Other acute disseminated demyelination
0.000 0.224 0.776
E51 Thiamine deficiency
0.000 0.227 0.773
E14.6 With other specified complications
0.000 0.227 0.773
K90 Intestinal malabsorption
0.000 0.228 0.772
E14.1 With ketoacidosis
0.000 0.232 0.768
E14.8 With unspecified complications
0.000 0.233 0.767
E03.8 Other specified hypothyroidism
0.000 0.237 0.763
E11.8 With unspecified complications
0.000 0.246 0.754
M45.X6 Ankylosing spondylitis (Lumbar region)
0.751 0.249 0.000
E10.8 With unspecified complications
0.000 0.253 0.747
M35.0 Sicca syndrome [Sjogren]
0.000 0.266 0.734
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.716 0.284 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.716 0.284 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.716 0.284 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.716 0.284 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.716 0.284 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.285 0.714
E06.9 Thyroiditis, unspecified
0.000 0.288 0.712
E55.9 Vitamin D deficiency, unspecified
0.000 0.292 0.708
E27 Other disorders of adrenal gland
0.000 0.292 0.708
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.294 0.706
E11.6 With other specified complications
0.000 0.296 0.704
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.297 0.703
E63 Other nutritional deficiencies
0.000 0.297 0.703
E50 Vitamin A deficiency
0.000 0.297 0.703
E60 Dietary zinc deficiency
0.000 0.297 0.703
E59 Dietary selenium deficiency
0.000 0.297 0.703
E52 Niacin deficiency [pellagra]
0.000 0.297 0.703
E14.4 With neurological complications
0.000 0.299 0.701
E14.5 With peripheral circulatory complications
0.000 0.301 0.699
G37.5 Concentric sclerosis [Balo]
0.000 0.302 0.698
G37.4 Subacute necrotising myelitis
0.000 0.302 0.698
G37.2 Central pontine myelinolysis
0.000 0.302 0.698
G37.1 Central demyelination of corpus callosum
0.000 0.302 0.698
G37.0 Diffuse sclerosis
0.000 0.302 0.698
K90.9 Intestinal malabsorption, unspecified
0.000 0.304 0.696
E53.1 Pyridoxine deficiency
0.000 0.304 0.696
E53.0 Riboflavin deficiency
0.000 0.304 0.696
E14.7 With multiple complications
0.000 0.306 0.694
E14.0 With coma
0.000 0.306 0.694
E27.1 Primary adrenocortical insufficiency
0.000 0.306 0.694
E05.8 Other thyrotoxicosis
0.000 0.310 0.690
E15 Nondiabetic hypoglycaemic coma
0.000 0.313 0.687
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.316 0.683
E03.1 Congenital hypothyroidism without goitre
0.000 0.321 0.679
E46 Unspecified protein-energy malnutrition
0.000 0.330 0.670
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.334 0.666
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.334 0.666
E16.4 Abnormal secretion of gastrin
0.000 0.334 0.666
E16.3 Increased secretion of glucagon
0.000 0.334 0.666
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.337 0.662
E11.7 With multiple complications
0.000 0.345 0.655
E54 Ascorbic acid deficiency
0.000 0.352 0.648
E06.4 Drug-induced thyroiditis
0.000 0.359 0.640
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.359 0.640
E06.0 Acute thyroiditis
0.000 0.359 0.640
L40 Psoriasis
0.638 0.362 0.000
H30-H36 Disorders of choroid and retina
0.000 0.363 0.637
G36.0 Neuromyelitis optica [Devic]
0.000 0.370 0.630
E58 Dietary calcium deficiency
0.000 0.370 0.630
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.372 0.628
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.375 0.625
E51.2 Wernicke's encephalopathy
0.000 0.376 0.624
H34 Retinal vascular occlusions
0.000 0.376 0.624
E20 Hypoparathyroidism
0.000 0.405 0.595
E55.0 Rickets, active
0.000 0.411 0.589
H34.2 Other retinal artery occlusions
0.000 0.414 0.586
E61 Deficiency of other nutrient elements
0.000 0.416 0.584
L40.8 Other psoriasis
0.580 0.420 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.421 0.579
E45 Retarded development following protein-energy malnutrition
0.000 0.421 0.579
E43 Unspecified severe protein-energy malnutrition
0.000 0.421 0.579
E42 Marasmic kwashiorkor
0.000 0.421 0.579
E41 Nutritional marasmus
0.000 0.421 0.579
E40 Kwashiorkor
0.000 0.421 0.579
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.423 0.577
E06.5 Other chronic thyroiditis
0.000 0.423 0.577
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.423 0.577
H34.8 Other retinal vascular occlusions
0.000 0.424 0.576
E56 Other vitamin deficiencies
0.000 0.425 0.575
H30 Chorioretinal inflammation
0.000 0.433 0.567
E27.8 Other specified disorders of adrenal gland
0.000 0.435 0.565
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.436 0.564
E06.1 Subacute thyroiditis
0.000 0.440 0.559
K90.8 Other intestinal malabsorption
0.000 0.442 0.558
G36.9 Acute disseminated demyelination, unspecified
0.000 0.444 0.556
G36.8 Other specified acute disseminated demyelination
0.000 0.444 0.556
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.444 0.556
E51.9 Thiamine deficiency, unspecified
0.000 0.446 0.554
E51.8 Other manifestations of thiamine deficiency
0.000 0.446 0.554
E51.1 Beriberi
0.000 0.446 0.554
K90.3 Pancreatic steatorrhoea
0.000 0.447 0.553
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.447 0.553
K90.1 Tropical sprue
0.000 0.447 0.553
E11.0 With coma
0.000 0.455 0.545
E31 Polyglandular dysfunction
0.000 0.458 0.542
I10 Essential (primary) hypertension
0.539 0.461 0.000
H31 Other disorders of choroid
0.000 0.461 0.539
E11.5 With peripheral circulatory complications
0.000 0.473 0.527
E20.9 Hypoparathyroidism, unspecified
0.000 0.478 0.522
E24 Cushing's syndrome
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E27.2 Addisonian crisis
0.000 0.488 0.512
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.488 0.512
E32 Diseases of thymus
0.000 0.488 0.512
E30 Disorders of puberty, not elsewhere classified
0.000 0.488 0.512
E13 Other specified diabetes mellitus
0.000 0.488 0.511
H30.9 Chorioretinal inflammation, unspecified
0.000 0.490 0.510
E27.5 Adrenomedullary hyperfunction
0.000 0.492 0.507
E27.0 Other adrenocortical overactivity
0.000 0.492 0.507
E25 Adrenogenital disorders
0.000 0.495 0.505
E50.9 Vitamin A deficiency, unspecified
0.000 0.496 0.504
E50.8 Other manifestations of vitamin A deficiency
0.000 0.496 0.504
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.496 0.504
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.496 0.504
E50.5 Vitamin A deficiency with night blindness
0.000 0.496 0.504
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.496 0.504
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.496 0.504
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.496 0.504
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.496 0.504
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.496 0.504
E63.9 Nutritional deficiency, unspecified
0.000 0.496 0.504
E63.8 Other specified nutritional deficiencies
0.000 0.496 0.504
E63.1 Imbalance of constituents of food intake
0.000 0.496 0.504
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.496 0.504
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.496 0.504
E64.8 Sequelae of other nutritional deficiencies
0.000 0.496 0.504
E64.3 Sequelae of rickets
0.000 0.496 0.504
E64.2 Sequelae of vitamin C deficiency
0.000 0.496 0.504
E64.1 Sequelae of vitamin A deficiency
0.000 0.496 0.504
E64.0 Sequelae of protein-energy malnutrition
0.000 0.496 0.504
H31.0 Chorioretinal scars
0.000 0.498 0.502
E65-E68 Obesity and other hyperalimentation
0.000 0.503 0.497
E11.2 With renal complications
0.000 0.508 0.492
L40.5 Arthropathic psoriasis
0.492 0.508 0.000
L40.1 Generalised pustular psoriasis
0.482 0.518 0.000
E61.2 Magnesium deficiency
0.000 0.528 0.472
H34.1 Central retinal artery occlusion
0.000 0.533 0.466
E26 Hyperaldosteronism
0.000 0.534 0.466
L40.2 Acrodermatitis continua
0.458 0.542 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.543 0.457
E07 Other disorders of thyroid
0.000 0.546 0.454
H34.0 Transient retinal artery occlusion
0.000 0.552 0.447
H34.9 Retinal vascular occlusion, unspecified
0.000 0.559 0.441
E27.9 Disorder of adrenal gland, unspecified
0.000 0.568 0.432
E20.1 Pseudohypoparathyroidism
0.000 0.573 0.427
E20.0 Idiopathic hypoparathyroidism
0.000 0.573 0.427
H30.2 Posterior cyclitis
0.000 0.574 0.426
L40.4 Guttate psoriasis
0.424 0.575 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.581 0.419
E61.8 Deficiency of other specified nutrient elements
0.000 0.581 0.419
E61.7 Deficiency of multiple nutrient elements
0.000 0.581 0.419
E61.6 Vanadium deficiency
0.000 0.581 0.419
E61.5 Molybdenum deficiency
0.000 0.581 0.419
E61.4 Chromium deficiency
0.000 0.581 0.419
E61.3 Manganese deficiency
0.000 0.581 0.419
E61.0 Copper deficiency
0.000 0.581 0.419
E31.0 Autoimmune polyglandular failure
0.000 0.581 0.418
E44.1 Mild protein-energy malnutrition
0.000 0.585 0.415
E44.0 Moderate protein-energy malnutrition
0.000 0.585 0.415
E56.9 Vitamin deficiency, unspecified
0.000 0.587 0.412
E56.8 Deficiency of other vitamins
0.000 0.587 0.412
E56.0 Deficiency of vitamin E
0.000 0.587 0.412
E16.1 Other hypoglycaemia
0.001 0.593 0.407
H30.8 Other chorioretinal inflammations
0.000 0.593 0.407
H30.1 Disseminated chorioretinal inflammation
0.000 0.593 0.407
H30.0 Focal chorioretinal inflammation
0.000 0.593 0.407
L40.3 Pustulosis palmaris et plantaris
0.406 0.594 0.000
E28 Ovarian dysfunction
0.002 0.594 0.403
E24.8 Other Cushing's syndrome
0.000 0.601 0.399
E20.8 Other hypoparathyroidism
0.000 0.602 0.398
H31.8 Other specified disorders of choroid
0.000 0.609 0.391
E31.9 Polyglandular dysfunction, unspecified
0.000 0.611 0.389
E31.8 Other polyglandular dysfunction
0.000 0.611 0.389
E31.1 Polyglandular hyperfunction
0.000 0.611 0.389
H31.4 Choroidal detachment
0.000 0.614 0.386
H31.2 Hereditary choroidal dystrophy
0.000 0.614 0.386
E22 Hyperfunction of pituitary gland
0.000 0.618 0.381
H31.3 Choroidal haemorrhage and rupture
0.000 0.623 0.377
H31.9 Disorder of choroid, unspecified
0.000 0.630 0.370
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.631 0.369
E24.3 Ectopic ACTH syndrome
0.000 0.631 0.369
E24.1 Nelson's syndrome
0.000 0.631 0.369
E24.0 Pituitary-dependent Cushing's disease
0.000 0.632 0.368
E30.9 Disorder of puberty, unspecified
0.000 0.632 0.367
E30.8 Other disorders of puberty
0.000 0.632 0.367
E30.1 Precocious puberty
0.000 0.632 0.367
E30.0 Delayed puberty
0.000 0.632 0.367
E32.9 Disease of thymus, unspecified
0.000 0.632 0.367
E32.8 Other diseases of thymus
0.000 0.632 0.367
E32.1 Abscess of thymus
0.000 0.632 0.367
E32.0 Persistent hyperplasia of thymus
0.000 0.632 0.367
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.632 0.367
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.632 0.367
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.632 0.367
E13.8 With unspecified complications
0.000 0.633 0.367
E13.7 With multiple complications
0.000 0.633 0.367
E13.6 With other specified complications
0.000 0.633 0.367
E13.5 With peripheral circulatory complications
0.000 0.633 0.367
E13.4 With neurological complications
0.000 0.633 0.367
E13.2 With renal complications
0.000 0.633 0.367
E13.1 With ketoacidosis
0.000 0.633 0.367
E13.0 With coma
0.000 0.633 0.367
E24.2 Drug-induced Cushing's syndrome
0.000 0.635 0.365
E13.3 With ophthalmic complications
0.000 0.636 0.364
E25.9 Adrenogenital disorder, unspecified
0.000 0.638 0.362
E25.8 Other adrenogenital disorders
0.000 0.638 0.362
E34 Other endocrine disorders
0.000 0.640 0.360
E67 Other hyperalimentation
0.000 0.643 0.356
E68 Sequelae of hyperalimentation
0.000 0.643 0.356
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.645 0.355
L40.0 Psoriasis vulgaris
0.351 0.648 0.000
E26.9 Hyperaldosteronism, unspecified
0.000 0.654 0.346
E29 Testicular dysfunction
0.001 0.658 0.341
E24.9 Cushing's syndrome, unspecified
0.000 0.659 0.341
E28.3 Primary ovarian failure
0.001 0.664 0.334
E26.8 Other hyperaldosteronism
0.000 0.665 0.334
E26.1 Secondary hyperaldosteronism
0.000 0.665 0.334
H32.8 Other chorioretinal disorders in diseases classified elsewhere
0.000 0.672 0.327
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
0.000 0.672 0.327
E07.1 Dyshormogenetic goitre
0.000 0.674 0.325
E07.0 Hypersecretion of calcitonin
0.000 0.674 0.325
E22.1 Hyperprolactinaemia
0.000 0.678 0.322
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.681 0.319
E28.9 Ovarian dysfunction, unspecified
0.002 0.709 0.289
E28.8 Other ovarian dysfunction
0.002 0.709 0.289
E28.1 Androgen excess
0.002 0.709 0.289
E28.0 Oestrogen excess
0.002 0.709 0.289
E56.1 Deficiency of vitamin K
0.001 0.715 0.284
H31.1 Choroidal degeneration
0.000 0.717 0.282
E66 Obesity
0.000 0.722 0.278
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.726 0.274
E22.8 Other hyperfunction of pituitary gland
0.000 0.726 0.274
E26.0 Primary hyperaldosteronism
0.000 0.728 0.272
E07.8 Other specified disorders of thyroid
0.000 0.732 0.267
E65 Localised adiposity
0.000 0.734 0.266
E34.3 Short stature, not elsewhere classified
0.000 0.741 0.259
E34.5 Androgen resistance syndrome
0.000 0.742 0.258
E34.4 Constitutional tall stature
0.000 0.742 0.258
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.742 0.258
E34.1 Other hypersecretion of intestinal hormones
0.000 0.742 0.258
E67.8 Other specified hyperalimentation
0.000 0.744 0.256
E67.3 Hypervitaminosis D
0.000 0.744 0.256
E67.2 Megavitamin-B6 syndrome
0.000 0.744 0.256
E67.1 Hypercarotenaemia
0.000 0.744 0.256
E67.0 Hypervitaminosis A
0.000 0.744 0.256
E21.4 Other specified disorders of parathyroid gland
0.000 0.753 0.247
E29.9 Testicular dysfunction, unspecified
0.001 0.755 0.245
E29.8 Other testicular dysfunction
0.001 0.755 0.245
E29.0 Testicular hyperfunction
0.001 0.755 0.245
E66.8 Other obesity
0.000 0.760 0.240
E34.8 Other specified endocrine disorders
0.000 0.767 0.232
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.769 0.231
E34.9 Endocrine disorder, unspecified
0.000 0.772 0.228
D61.9 Aplastic anaemia, unspecified
0.000 0.776 0.224
E66.0 Obesity due to excess calories
0.000 0.778 0.222
E21.2 Other hyperparathyroidism
0.000 0.782 0.217
E23 Hypofunction and other disorders of pituitary gland
0.001 0.789 0.210
D61 Other aplastic anaemias
0.000 0.793 0.207
E22.0 Acromegaly and pituitary gigantism
0.000 0.797 0.203
E34.0 Carcinoid syndrome
0.000 0.798 0.201
E66.1 Drug-induced obesity
0.000 0.801 0.199
E21.0 Primary hyperparathyroidism
0.000 0.801 0.199
E07.9 Disorder of thyroid, unspecified
0.000 0.816 0.184
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.817 0.183
D60-D64 Aplastic and other anaemias
0.000 0.818 0.182
L40-L45 Papulosquamous disorders
0.180 0.819 0.002
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.827 0.173
E13.9 Without complications
0.001 0.832 0.168
D61.0 Constitutional aplastic anaemia
0.000 0.834 0.166
D61.1 Drug-induced aplastic anaemia
0.000 0.836 0.163
D50-D53 Nutritional anaemias
0.000 0.837 0.163
E61.1 Iron deficiency
0.000 0.837 0.163
E21.3 Hyperparathyroidism, unspecified
0.000 0.839 0.161
M35 Other systemic involvement of connective tissue
0.000 0.841 0.159
D51 Vitamin B12 deficiency anaemia
0.000 0.847 0.153
D64 Other anaemias
0.000 0.847 0.153
D80-D89 Certain disorders involving the immune mechanism
0.000 0.848 0.152
E23.1 Drug-induced hypopituitarism
0.001 0.849 0.151
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.852 0.148
D61.8 Other specified aplastic anaemias
0.000 0.852 0.148
D61.3 Idiopathic aplastic anaemia
0.000 0.852 0.148
D61.2 Aplastic anaemia due to other external agents
0.000 0.852 0.148
D69 Purpura and other haemorrhagic conditions
0.000 0.854 0.146
L41 Parapsoriasis
0.145 0.854 0.001
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.854 0.145
E23.7 Disorder of pituitary gland, unspecified
0.000 0.854 0.145
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.855 0.145
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.857 0.143
E14.9 Without complications
0.000 0.857 0.142
C85.1 B-cell lymphoma, unspecified
0.000 0.858 0.142
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.859 0.141
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.860 0.140
M45-M49 Spondylopathies
0.140 0.860 0.000
E23.2 Diabetes insipidus
0.000 0.860 0.139
E23.6 Other disorders of pituitary gland
0.000 0.861 0.138
E04 Other non-toxic goitre
0.000 0.862 0.138
D69.6 Thrombocytopenia, unspecified
0.000 0.863 0.137
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.864 0.136
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.001 0.865 0.134
D64.9 Anaemia, unspecified
0.000 0.866 0.134
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.867 0.133
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.867 0.133
L44 Other papulosquamous disorders
0.130 0.869 0.001
L45 Papulosquamous disorders in diseases classified elsewhere
0.129 0.870 0.001
D53 Other nutritional anaemias
0.000 0.870 0.130
C91 Lymphoid leukaemia
0.000 0.870 0.130
C90 Multiple myeloma and malignant plasma cell neoplasms
0.000 0.871 0.129
L42 Pityriasis rosea
0.127 0.872 0.001
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.873 0.127
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.873 0.127
C91.4 Hairy-cell leukaemia
0.000 0.874 0.126
D72 Other disorders of white blood cells
0.000 0.876 0.124
D89.1 Cryoglobulinaemia
0.000 0.877 0.123
C90.2 Plasmacytoma, extramedullary
0.000 0.878 0.122
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.878 0.122
D69.5 Secondary thrombocytopenia
0.000 0.878 0.122
L41.1 Pityriasis lichenoides chronica
0.120 0.880 0.001
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.880 0.120
C81 Hodgkin's disease
0.000 0.880 0.120
D50 Iron deficiency anaemia
0.000 0.880 0.120
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.881 0.119
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.881 0.119
D75 Other diseases of blood and blood-forming organs
0.000 0.881 0.119
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.883 0.117
D69.2 Other nonthrombocytopenic purpura
0.000 0.883 0.117
D52 Folate deficiency anaemia
0.000 0.883 0.117
D84 Other immunodeficiencies
0.000 0.885 0.115
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.886 0.114
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.886 0.114
M35.5 Multifocal fibrosclerosis
0.000 0.886 0.114
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.886 0.114
C88 Malignant immunoproliferative diseases
0.000 0.886 0.114
M49 Spondylopathies in diseases classified elsewhere
0.114 0.886 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.887 0.113
D69.0 Allergic purpura
0.000 0.887 0.113
C90.3 Solitary plasmacytoma
0.000 0.888 0.112
D69.4 Other primary thrombocytopenia
0.000 0.888 0.111
D83 Common variable immunodeficiency
0.000 0.889 0.111
M35.1 Other overlap syndromes
0.000 0.889 0.111
D55-D59 Haemolytic anaemias
0.000 0.889 0.111
D72.8 Other specified disorders of white blood cells
0.000 0.889 0.111
D64.3 Other sideroblastic anaemias
0.000 0.890 0.110
D66 Hereditary factor VIII deficiency
0.000 0.890 0.110
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.890 0.110
D51.2 Transcobalamin II deficiency
0.000 0.890 0.110
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.890 0.110
D64.4 Congenital dyserythropoietic anaemia
0.000 0.890 0.109
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.890 0.109
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.890 0.109
D64.0 Hereditary sideroblastic anaemia
0.000 0.890 0.109
E04.0 Non-toxic diffuse goitre
0.000 0.890 0.110
D81 Combined immunodeficiencies
0.000 0.891 0.109
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.892 0.108
C83.0 Small cell (diffuse)
0.000 0.892 0.108
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.893 0.107
M35.7 Hypermobility syndrome
0.000 0.894 0.106
D70 Agranulocytosis
0.000 0.894 0.106
D53.9 Nutritional anaemia, unspecified
0.000 0.894 0.106
D69.8 Other specified haemorrhagic conditions
0.000 0.895 0.105
D82 Immunodeficiency associated with other major defects
0.000 0.895 0.105
L41.9 Parapsoriasis, unspecified
0.104 0.895 0.001
L41.8 Other parapsoriasis
0.104 0.895 0.001
L41.5 Retiform parapsoriasis
0.104 0.895 0.001
L41.4 Large plaque parapsoriasis
0.104 0.895 0.001
L41.3 Small plaque parapsoriasis
0.104 0.895 0.001
L41.2 Lymphomatoid papulosis
0.104 0.895 0.001
L41.0 Pityriasis lichenoides et varioliformis acuta
0.104 0.895 0.001
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.895 0.105
M35.8 Other specified systemic involvement of connective tissue
0.000 0.895 0.105
D89.3 Immune reconstitution syndrome
0.000 0.896 0.104
I10-I15 Hypertensive diseases
0.104 0.896 0.000
D69.9 Haemorrhagic condition, unspecified
0.000 0.897 0.103
D64.8 Other specified anaemias
0.000 0.897 0.103
C85.0 Lymphosarcoma
0.000 0.897 0.103
M46 Other inflammatory spondylopathies
0.103 0.897 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.898 0.102
M35.2 Behcet's disease
0.000 0.898 0.102
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.899 0.101
D74 Methaemoglobinaemia
0.000 0.899 0.101
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.899 0.101
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.899 0.101
C81.9 Hodgkin's disease, unspecified
0.000 0.899 0.101
C88.0 Waldenstrom's macroglobulinaemia
0.000 0.900 0.100
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.900 0.100
E04.8 Other specified non-toxic goitre
0.000 0.901 0.099
M35.3 Polymyalgia rheumatica
0.000 0.902 0.098
C94 Other leukaemias of specified cell type
0.000 0.902 0.098
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.902 0.098
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.902 0.097
D63.0 Anaemia in neoplastic disease
0.000 0.903 0.097
C91.0 Acute lymphoblastic leukaemia
0.000 0.903 0.097
D63.8 Anaemia in other chronic diseases classified elsewhere
0.000 0.904 0.096
E11.4 With neurological complications
0.001 0.904 0.095
D63.1 Anaemia in other chronic diseases classified elsewhere
0.000 0.904 0.095
D50.9 Iron deficiency anaemia, unspecified
0.000 0.905 0.095
C81.0 Lymphocytic predominance
0.000 0.905 0.095
C81.1 Nodular sclerosis
0.000 0.905 0.095
M49.5 Collapsed vertebra in diseases classified elsewhere
0.095 0.905 0.000
L44.0 Pityriasis rubra pilaris
0.094 0.905 0.001
D80 Immunodeficiency with predominantly antibody defects
0.000 0.906 0.094
L44.9 Papulosquamous disorder, unspecified
0.093 0.906 0.001
L44.8 Other specified papulosquamous disorders
0.093 0.906 0.001
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.093 0.906 0.001
L44.3 Lichen ruber moniliformis
0.093 0.906 0.001
L44.2 Lichen striatus
0.093 0.906 0.001
L44.1 Lichen nitidus
0.093 0.906 0.001
D53.8 Other specified nutritional anaemias
0.000 0.907 0.093
D53.2 Scorbutic anaemia
0.000 0.907 0.093
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.907 0.093
D53.0 Protein deficiency anaemia
0.000 0.907 0.093
C86 Other specified types of T/NK-cell lymphoma
0.000 0.907 0.093
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.907 0.093
C91.8 Mature B-cell leukaemia Burkitt-type
0.000 0.907 0.093
C91.7 Other lymphoid leukaemia
0.000 0.907 0.093
C91.6 Prolymphocytic leukaemia of T-cell type
0.000 0.907 0.093
C91.3 Prolymphocytic leukaemia
0.000 0.907 0.093
C91.2 Subacute lymphocytic leukaemia
0.000 0.907 0.093
D72.1 Eosinophilia
0.000 0.907 0.093
M46.4 Discitis, unspecified
0.093 0.907 0.000
C91.1 Chronic lymphocytic leukaemia
0.000 0.907 0.093
C91.9 Lymphoid leukaemia, unspecified
0.000 0.907 0.093

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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