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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs231735
log Bayes Factor = 32.1003
Chromosome 2   position 204,693,876  (GRCh37) Explore rs231735 on Ensembl!
Variant rs231735 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E06 Thyroiditis
0.000 0.005 0.995
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.007 0.993
E06.3 Autoimmune thyroiditis
0.000 0.015 0.985
E07 Other disorders of thyroid
0.000 0.158 0.842
E06.5 Other chronic thyroiditis
0.000 0.163 0.837
E06.9 Thyroiditis, unspecified
0.000 0.178 0.822
E05.8 Other thyrotoxicosis
0.000 0.183 0.817
E03.1 Congenital hypothyroidism without goitre
0.000 0.199 0.801
E07.9 Disorder of thyroid, unspecified
0.000 0.245 0.755
E03.8 Other specified hypothyroidism
0.000 0.260 0.740
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.273 0.727
E06.1 Subacute thyroiditis
0.000 0.281 0.719
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E06.4 Drug-induced thyroiditis
0.000 0.286 0.713
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.286 0.713
E06.0 Acute thyroiditis
0.000 0.286 0.713
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.297 0.702
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.310 0.690
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.317 0.682
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.352 0.648
E10-E14 Diabetes mellitus
0.000 0.361 0.639
E10 Insulin-dependent diabetes mellitus
0.000 0.364 0.636
E10.9 Without complications
0.000 0.371 0.629
E10.1 With ketoacidosis
0.000 0.374 0.626
E07.1 Dyshormogenetic goitre
0.000 0.396 0.604
E07.0 Hypersecretion of calcitonin
0.000 0.396 0.604
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.439 0.561
E10.4 With neurological complications
0.000 0.461 0.539
E07.8 Other specified disorders of thyroid
0.000 0.466 0.533
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E16 Other disorders of pancreatic internal secretion
0.000 0.501 0.499
E14 Unspecified diabetes mellitus
0.000 0.520 0.480
E16.2 Hypoglycaemia, unspecified
0.000 0.531 0.469
E12 Malnutrition-related diabetes mellitus
0.000 0.542 0.458
E10.7 With multiple complications
0.000 0.543 0.457
E10.8 With unspecified complications
0.000 0.546 0.454
E40-E46 Malnutrition
0.000 0.548 0.452
E11 Non-insulin-dependent diabetes mellitus
0.000 0.551 0.449
E14.4 With neurological complications
0.000 0.563 0.437
E10.2 With renal complications
0.000 0.576 0.424
E14.2 Withrenal complications
0.000 0.588 0.412
E11.5 With peripheral circulatory complications
0.000 0.588 0.412
E89.0 Postprocedural hypothyroidism
0.000 0.589 0.411
E70-E90 Metabolic disorders
0.000 0.590 0.410
E14.8 With unspecified complications
0.000 0.592 0.408
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.595 0.405
E15 Nondiabetic hypoglycaemic coma
0.000 0.597 0.402
E11.2 With renal complications
0.000 0.598 0.402
E10.6 With other specified complications
0.000 0.614 0.386
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.623 0.376
E85 Amyloidosis
0.000 0.625 0.375
E10.0 With coma
0.000 0.640 0.360
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.642 0.358
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.642 0.358
E16.4 Abnormal secretion of gastrin
0.000 0.642 0.358
E16.3 Increased secretion of glucagon
0.000 0.642 0.358
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.643 0.357
E16.1 Other hypoglycaemia
0.000 0.650 0.350
E13 Other specified diabetes mellitus
0.000 0.650 0.350
E14.7 With multiple complications
0.000 0.656 0.344
E85.9 Amyloidosis, unspecified
0.000 0.656 0.344
E11.3 With ophthalmic complications
0.000 0.659 0.341
E14.5 With peripheral circulatory complications
0.000 0.660 0.340
E11.4 With neurological complications
0.000 0.660 0.340
E14.1 With ketoacidosis
0.000 0.666 0.334
E50-E64 Other nutritional deficiencies
0.000 0.669 0.331
E12.9 Without complications
0.000 0.671 0.328
E12.8 With unspecified complications
0.000 0.671 0.328
E12.7 With multiple complications
0.000 0.671 0.328
E12.6 With other specified complications
0.000 0.671 0.328
E12.5 With peripheral circulatory complications
0.000 0.671 0.328
E12.4 With neurological complications
0.000 0.671 0.328
E12.3 With ophthalmic complications
0.000 0.671 0.328
E12.2 With renal complications
0.000 0.671 0.328
E12.1 With ketoacidosis
0.000 0.671 0.328
E12.0 With coma
0.000 0.671 0.328
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.676 0.324
E45 Retarded development following protein-energy malnutrition
0.000 0.676 0.324
E43 Unspecified severe protein-energy malnutrition
0.000 0.676 0.324
E42 Marasmic kwashiorkor
0.000 0.676 0.324
E41 Nutritional marasmus
0.000 0.676 0.324
E40 Kwashiorkor
0.000 0.676 0.324
E11.8 With unspecified complications
0.000 0.683 0.317
E11.7 With multiple complications
0.000 0.684 0.316
E14.3 With ophthalmic complications
0.000 0.688 0.312
E46 Unspecified protein-energy malnutrition
0.000 0.688 0.312
E89.2 Postprocedural hypoparathyroidism
0.000 0.697 0.303
E80.4 Gilbert's syndrome
0.000 0.698 0.302
E84 Cystic fibrosis
0.000 0.700 0.300
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.700 0.300
E61 Deficiency of other nutrient elements
0.000 0.702 0.298
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.704 0.296
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.705 0.295
E77 Disorders of glycoprotein metabolism
0.000 0.706 0.294
E76 Disorders of glycosaminoglycan metabolism
0.000 0.706 0.294
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.706 0.294
E70 Disorders of aromatic amino-acid metabolism
0.000 0.706 0.294
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.706 0.294
E14.6 With other specified complications
0.000 0.707 0.292
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.709 0.291
E11.6 With other specified complications
0.000 0.710 0.290
E89.4 Postprocedural ovarian failure
0.000 0.712 0.287
E10.5 With peripheral circulatory complications
0.000 0.714 0.286
E79 Disorders of purine and pyrimidine metabolism
0.000 0.718 0.282
E85.8 Other amyloidosis
0.000 0.719 0.281
E61.1 Iron deficiency
0.000 0.721 0.279
E80.1 Porphyria cutanea tarda
0.000 0.726 0.274
E72 Other disorders of amino-acid metabolism
0.000 0.728 0.272
E85.4 Organ-limited amyloidosis
0.000 0.728 0.271
E85.3 Secondary systemic amyloidosis
0.000 0.729 0.271
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.729 0.271
E11.1 With ketoacidosis
0.000 0.729 0.271
E89.1 Postprocedural hypoinsulinaemia
0.000 0.731 0.269
E80.6 Other disorders of bilirubin metabolism
0.000 0.731 0.269
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.731 0.269
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.731 0.269
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.731 0.269
E89.3 Postprocedural hypopituitarism
0.000 0.736 0.264
E14.0 With coma
0.000 0.738 0.262
E80.2 Other porphyria
0.000 0.738 0.262
E89.5 Postprocedural testicular hypofunction
0.000 0.740 0.260
I85.9 Oesophageal varices without bleeding
0.000 0.740 0.260
E74 Other disorders of carbohydrate metabolism
0.000 0.742 0.258
I85 Oesophageal varices
0.000 0.743 0.257
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.743 0.257
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.744 0.256
E80.5 Crigler-Najjar syndrome
0.000 0.744 0.256
E80.3 Defects of catalase and peroxydase
0.000 0.744 0.256
E80.0 Hereditary erythropoietic porphyria
0.000 0.744 0.256
E13.8 With unspecified complications
0.000 0.749 0.251
E13.7 With multiple complications
0.000 0.749 0.251
E13.6 With other specified complications
0.000 0.749 0.251
E13.5 With peripheral circulatory complications
0.000 0.749 0.251
E13.4 With neurological complications
0.000 0.749 0.251
E13.2 With renal complications
0.000 0.749 0.251
E13.1 With ketoacidosis
0.000 0.749 0.251
E13.0 With coma
0.000 0.749 0.251
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.000 0.753 0.247
I89.0 Lymphoedema, not elsewhere classified
0.000 0.754 0.246
I81 Portal vein thrombosis
0.000 0.756 0.244
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.756 0.244
E73 Lactose intolerance
0.000 0.759 0.241
I85.0 Oesophageal varices with bleeding
0.000 0.761 0.239
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.762 0.237
E63 Other nutritional deficiencies
0.000 0.762 0.237
E50 Vitamin A deficiency
0.000 0.762 0.237
E60 Dietary zinc deficiency
0.000 0.762 0.237
E59 Dietary selenium deficiency
0.000 0.762 0.237
E54 Ascorbic acid deficiency
0.000 0.762 0.237
E52 Niacin deficiency [pellagra]
0.000 0.762 0.237
E58 Dietary calcium deficiency
0.000 0.763 0.237
E44.1 Mild protein-energy malnutrition
0.000 0.767 0.233
E44.0 Moderate protein-energy malnutrition
0.000 0.767 0.233
E51 Thiamine deficiency
0.000 0.778 0.222
E84.9 Cystic fibrosis, unspecified
0.000 0.778 0.222
E13.3 With ophthalmic complications
0.000 0.779 0.221
E56 Other vitamin deficiencies
0.000 0.782 0.217
E84.8 Cystic fibrosis with other manifestations
0.000 0.784 0.215
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.784 0.215
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.784 0.215
E75.2 Other sphingolipidosis
0.000 0.785 0.215
E61.9 Deficiency of nutrient element, unspecified
0.000 0.786 0.214
E61.8 Deficiency of other specified nutrient elements
0.000 0.786 0.214
E61.7 Deficiency of multiple nutrient elements
0.000 0.786 0.214
E61.6 Vanadium deficiency
0.000 0.786 0.214
E61.5 Molybdenum deficiency
0.000 0.786 0.214
E61.4 Chromium deficiency
0.000 0.786 0.214
E61.3 Manganese deficiency
0.000 0.786 0.214
E61.0 Copper deficiency
0.000 0.786 0.214
E75.6 Lipid storage disorder, unspecified
0.000 0.788 0.212
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.788 0.212
E75.3 Sphingolipidosis, unspecified
0.000 0.788 0.212
E75.1 Other gangliosidosis
0.000 0.788 0.212
E75.0 GM2 gangliosidosis
0.000 0.788 0.212
E75.5 Other lipid storage disorders
0.000 0.789 0.211
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.789 0.211
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.789 0.211
E70.3 Albinism
0.000 0.789 0.211
E70.2 Disorders of tyrosine metabolism
0.000 0.789 0.211
E70.1 Other hyperphenylalaninaemias
0.000 0.789 0.211
E70.0 Classical phenylketonuria
0.000 0.789 0.211
E71.3 Disorders of fatty-acid metabolism
0.000 0.789 0.211
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.789 0.211
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.789 0.211
E71.0 Maple-syrup-urine disease
0.000 0.789 0.211
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.789 0.211
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.789 0.211
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.789 0.211
E76.2 Other mucopolysaccharidoses
0.000 0.789 0.211
E76.1 Mucopolysaccharidosis, type II
0.000 0.789 0.211
E76.0 Mucopolysaccharidosis, type I
0.000 0.789 0.211
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.789 0.211
E77.8 Other disorders of glycoprotein metabolism
0.000 0.789 0.211
E77.1 Defects in glycoprotein degradation
0.000 0.789 0.211
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.789 0.211
E20-E35 Disorders of other endocrine glands
0.000 0.790 0.210
I89.1 Lymphangitis
0.000 0.791 0.209
E65-E68 Obesity and other hyperalimentation
0.000 0.791 0.209
E87.2 Acidosis
0.000 0.792 0.208
E87.3 Alkalosis
0.000 0.792 0.208
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.793 0.207
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes
0.000 0.794 0.206
E87.5 Hyperkalaemia
0.000 0.796 0.204
I82 Other venous embolism and thrombosis
0.000 0.797 0.203
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.798 0.202
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.798 0.202
E79.1 Lesch-Nyhan syndrome
0.000 0.798 0.202
I88 Nonspecific lymphadenitis
0.000 0.798 0.202
E61.2 Magnesium deficiency
0.000 0.803 0.196
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.804 0.195
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.804 0.195
E72.5 Disorders of glycine metabolism
0.000 0.804 0.195
E72.4 Disorders of ornithine metabolism
0.000 0.804 0.195
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.804 0.195
E72.2 Disorders of urea cycle metabolism
0.000 0.804 0.195
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.804 0.195
E87.4 Mixed disorder of acid-base balance
0.000 0.805 0.195
E04 Other non-toxic goitre
0.000 0.806 0.194
E28 Ovarian dysfunction
0.000 0.806 0.193
E11.0 With coma
0.000 0.808 0.191
E13.9 Without complications
0.000 0.809 0.191
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.810 0.190
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.815 0.185
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.815 0.185
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.815 0.185
E74.2 Disorders of galactose metabolism
0.000 0.815 0.185
E74.1 Disorders of fructose metabolism
0.000 0.815 0.185
E28.2 Polycystic ovarian syndrome
0.000 0.815 0.185
E74.0 Glycogen storage disease
0.000 0.820 0.179
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.000 0.826 0.174
I88.9 Nonspecific lymphadenitis, unspecified
0.000 0.826 0.174
E72.0 Disorders of amino-acid transport
0.000 0.826 0.174
E34 Other endocrine disorders
0.000 0.826 0.174
E73.8 Other lactose intolerance
0.000 0.827 0.173
E73.1 Secondary lactase deficiency
0.000 0.827 0.173
E73.0 Congenital lactase deficiency
0.000 0.827 0.173
I82.9 Embolism and thrombosis of unspecified vein
0.000 0.828 0.172
E50.9 Vitamin A deficiency, unspecified
0.000 0.829 0.170
E50.8 Other manifestations of vitamin A deficiency
0.000 0.829 0.170
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.829 0.170
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.829 0.170
E50.5 Vitamin A deficiency with night blindness
0.000 0.829 0.170
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.829 0.170
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.829 0.170
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.829 0.170
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.829 0.170
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.829 0.170
E63.9 Nutritional deficiency, unspecified
0.000 0.829 0.170
E63.8 Other specified nutritional deficiencies
0.000 0.829 0.170
E63.1 Imbalance of constituents of food intake
0.000 0.829 0.170
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.829 0.170
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.829 0.170
E64.8 Sequelae of other nutritional deficiencies
0.000 0.829 0.170
E64.3 Sequelae of rickets
0.000 0.829 0.170
E64.2 Sequelae of vitamin C deficiency
0.000 0.829 0.170
E64.1 Sequelae of vitamin A deficiency
0.000 0.829 0.170
E64.0 Sequelae of protein-energy malnutrition
0.000 0.829 0.170
E51.9 Thiamine deficiency, unspecified
0.000 0.840 0.159
E51.8 Other manifestations of thiamine deficiency
0.000 0.840 0.159
E51.1 Beriberi
0.000 0.840 0.159
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.843 0.157
I82.2 Embolism and thrombosis of vena cava
0.000 0.843 0.157
E55 Vitamin D deficiency
0.000 0.843 0.156
E56.9 Vitamin deficiency, unspecified
0.000 0.844 0.156
E56.8 Deficiency of other vitamins
0.000 0.844 0.156
E56.0 Deficiency of vitamin E
0.000 0.844 0.156
I82.3 Embolism and thrombosis of renal vein
0.000 0.846 0.154
I80 Phlebitis and thrombophlebitis
0.000 0.847 0.153
I88.8 Other nonspecific lymphadenitis
0.000 0.849 0.151
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.849 0.151
E32 Diseases of thymus
0.000 0.849 0.151
E31 Polyglandular dysfunction
0.000 0.849 0.151
E30 Disorders of puberty, not elsewhere classified
0.000 0.849 0.151
E67 Other hyperalimentation
0.000 0.850 0.150
E68 Sequelae of hyperalimentation
0.000 0.850 0.150
E24 Cushing's syndrome
0.000 0.852 0.148
I80.8 Phlebitis and thrombophlebitis of other sites
0.000 0.854 0.146
I82.1 Thrombophlebitis migrans
0.000 0.854 0.146
I88.1 Chronic lymphadenitis, except mesenteric
0.000 0.855 0.145
E34.0 Carcinoid syndrome
0.000 0.855 0.145
E51.2 Wernicke's encephalopathy
0.000 0.856 0.144
E87.6 Hypokalaemia
0.000 0.856 0.144
E34.8 Other specified endocrine disorders
0.000 0.856 0.144
E04.0 Non-toxic diffuse goitre
0.000 0.857 0.143
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.000 0.858 0.142
I82.0 Budd-Chiari syndrome
0.000 0.859 0.141
E04.8 Other specified non-toxic goitre
0.000 0.860 0.139
E87.0 Hyperosmolality and hypernatraemia
0.000 0.861 0.139
E28.9 Ovarian dysfunction, unspecified
0.000 0.861 0.139
E28.8 Other ovarian dysfunction
0.000 0.861 0.139
E28.1 Androgen excess
0.000 0.861 0.139
E28.0 Oestrogen excess
0.000 0.861 0.139
E20 Hypoparathyroidism
0.000 0.861 0.139
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.863 0.136
E56.1 Deficiency of vitamin K
0.000 0.864 0.135
I82.8 Embolism and thrombosis of other specified veins
0.000 0.865 0.135
I88.0 Nonspecific mesenteric lymphadenitis
0.000 0.866 0.134
E27 Other disorders of adrenal gland
0.000 0.867 0.133
E22 Hyperfunction of pituitary gland
0.000 0.867 0.133
E29 Testicular dysfunction
0.000 0.868 0.132
E25 Adrenogenital disorders
0.000 0.869 0.131
E10.3 With ophthalmic complications
0.000 0.869 0.130
E34.3 Short stature, not elsewhere classified
0.000 0.874 0.126
E28.3 Primary ovarian failure
0.000 0.875 0.125
E34.5 Androgen resistance syndrome
0.000 0.875 0.125
E34.4 Constitutional tall stature
0.000 0.875 0.125
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.875 0.125
E34.1 Other hypersecretion of intestinal hormones
0.000 0.875 0.125
E04.1 Non-toxic single thyroid nodule
0.000 0.876 0.124
E88 Other metabolic disorders
0.000 0.879 0.121
E73.9 Lactose intolerance, unspecified
0.000 0.880 0.120
E27.1 Primary adrenocortical insufficiency
0.000 0.883 0.117
E24.2 Drug-induced Cushing's syndrome
0.000 0.885 0.115
E65 Localised adiposity
0.000 0.887 0.113
E55.0 Rickets, active
0.000 0.887 0.112
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.889 0.111
E27.2 Addisonian crisis
0.000 0.890 0.110
E26 Hyperaldosteronism
0.000 0.892 0.108
E30.9 Disorder of puberty, unspecified
0.000 0.892 0.108
E30.8 Other disorders of puberty
0.000 0.892 0.108
E30.1 Precocious puberty
0.000 0.892 0.108
E30.0 Delayed puberty
0.000 0.892 0.108
E31.9 Polyglandular dysfunction, unspecified
0.000 0.892 0.108
E31.8 Other polyglandular dysfunction
0.000 0.892 0.108
E31.1 Polyglandular hyperfunction
0.000 0.892 0.108
E31.0 Autoimmune polyglandular failure
0.000 0.892 0.108
E32.9 Disease of thymus, unspecified
0.000 0.892 0.108
E32.8 Other diseases of thymus
0.000 0.892 0.108
E32.1 Abscess of thymus
0.000 0.892 0.108
E32.0 Persistent hyperplasia of thymus
0.000 0.892 0.108
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.892 0.108
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.892 0.108
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.892 0.108
E67.8 Other specified hyperalimentation
0.000 0.892 0.108
E67.3 Hypervitaminosis D
0.000 0.892 0.108
E67.2 Megavitamin-B6 syndrome
0.000 0.892 0.108
E67.1 Hypercarotenaemia
0.000 0.892 0.108
E67.0 Hypervitaminosis A
0.000 0.892 0.108
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.894 0.106
E24.3 Ectopic ACTH syndrome
0.000 0.894 0.106
E24.1 Nelson's syndrome
0.000 0.894 0.106
E22.0 Acromegaly and pituitary gigantism
0.000 0.894 0.106
E87.7 Fluid overload
0.000 0.896 0.104
E24.8 Other Cushing's syndrome
0.000 0.897 0.103
E24.9 Cushing's syndrome, unspecified
0.000 0.898 0.102
E23 Hypofunction and other disorders of pituitary gland
0.000 0.900 0.100
E20.8 Other hypoparathyroidism
0.000 0.900 0.100
E20.1 Pseudohypoparathyroidism
0.000 0.900 0.100
E20.0 Idiopathic hypoparathyroidism
0.000 0.900 0.100
E24.0 Pituitary-dependent Cushing's disease
0.000 0.900 0.099
E34.9 Endocrine disorder, unspecified
0.000 0.901 0.099
E22.1 Hyperprolactinaemia
0.000 0.902 0.098
E27.5 Adrenomedullary hyperfunction
0.000 0.904 0.096
E27.0 Other adrenocortical overactivity
0.000 0.904 0.096
E22.8 Other hyperfunction of pituitary gland
0.000 0.904 0.095
E29.9 Testicular dysfunction, unspecified
0.000 0.905 0.095
E29.8 Other testicular dysfunction
0.000 0.905 0.095
E29.0 Testicular hyperfunction
0.000 0.905 0.095
E86 Volume depletion
0.000 0.905 0.095
E25.9 Adrenogenital disorder, unspecified
0.000 0.906 0.094
E25.8 Other adrenogenital disorders
0.000 0.906 0.094
E53 Deficiency of other B group vitamins
0.001 0.910 0.090
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.911 0.089
E88.2 Lipomatosis, not elsewhere classified
0.000 0.912 0.088
E20.9 Hypoparathyroidism, unspecified
0.000 0.912 0.088
E88.8 Other specified metabolic disorders
0.000 0.915 0.085
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.918 0.082
E26.8 Other hyperaldosteronism
0.000 0.922 0.078
E26.1 Secondary hyperaldosteronism
0.000 0.922 0.078
E23.7 Disorder of pituitary gland, unspecified
0.000 0.923 0.077
E29.1 Testicular hypofunction
0.000 0.924 0.076
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.925 0.074
I80.9 Phlebitis and thrombophlebitis of unspecified site
0.000 0.926 0.074
E88.9 Metabolic disorder, unspecified
0.000 0.928 0.072
E26.9 Hyperaldosteronism, unspecified
0.000 0.928 0.072
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.928 0.072
E23.1 Drug-induced hypopituitarism
0.000 0.928 0.072
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified
0.000 0.930 0.070
I86 Varicose veins of other sites
0.000 0.931 0.068
E88.3 Tumour lysis syndrome
0.001 0.935 0.065
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.935 0.065
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.935 0.065
E53.1 Pyridoxine deficiency
0.001 0.935 0.064
E53.0 Riboflavin deficiency
0.001 0.935 0.064
E23.2 Diabetes insipidus
0.000 0.935 0.064
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.938 0.062
E27.8 Other specified disorders of adrenal gland
0.000 0.939 0.061
E23.6 Other disorders of pituitary gland
0.000 0.943 0.057
I87 Other disorders of veins
0.000 0.945 0.055
E78.8 Other disorders of lipoprotein metabolism
0.000 0.946 0.054
E78.4 Other hyperlipidaemia
0.000 0.946 0.054
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.947 0.053
I83 Varicose veins of lower extremities
0.000 0.948 0.052
I86.3 Vulval varices
0.000 0.949 0.051
E78.6 Lipoprotein deficiency
0.000 0.949 0.051
E23.0 Hypopituitarism
0.000 0.949 0.051
I86.0 Sublingual varices
0.000 0.951 0.049
E83 Disorders of mineral metabolism
0.000 0.952 0.048
E26.0 Primary hyperaldosteronism
0.001 0.953 0.047
E78.2 Mixed hyperlipidaemia
0.000 0.954 0.046
E78.3 Hyperchylomicronaemia
0.000 0.954 0.046
I86.4 Gastric varices
0.000 0.955 0.045
E14.9 Without complications
0.000 0.955 0.045
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.956 0.044
E04.9 Non-toxic goitre, unspecified
0.000 0.956 0.043
I86.2 Pelvic varices
0.000 0.958 0.042
I80.1 Phlebitis and thrombophlebitis of femoral vein
0.000 0.958 0.042
I86.8 Varicose veins of other specified sites
0.000 0.958 0.041
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.960 0.040
I87.0 Postphlebitic syndrome
0.000 0.960 0.040
I83.1 Varicose veins of lower extremities with inflammation
0.000 0.961 0.039
E21.4 Other specified disorders of parathyroid gland
0.000 0.961 0.039
E27.9 Disorder of adrenal gland, unspecified
0.001 0.962 0.037
E53.9 Vitamin B deficiency, unspecified
0.001 0.964 0.035
I87.8 Other specified disorders of veins
0.000 0.964 0.036
E21.2 Other hyperparathyroidism
0.000 0.965 0.035
I87.9 Disorder of vein, unspecified
0.000 0.965 0.035
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.965 0.035
E83.8 Other disorders of mineral metabolism
0.000 0.965 0.035
E83.2 Disorders of zinc metabolism
0.000 0.965 0.035
E83.0 Disorders of copper metabolism
0.000 0.965 0.035
E83.1 Disorders of iron metabolism
0.000 0.966 0.034
G81.9 Hemiplegia, unspecified
0.034 0.966 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.966 0.034
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.968 0.031
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.000 0.968 0.031
E55.9 Vitamin D deficiency, unspecified
0.000 0.969 0.031
E78.1 Pure hyperglyceridaemia
0.000 0.971 0.029
K25.3 Acute without haemorrhage or perforation
0.025 0.975 0.000
I87.2 Venous insufficiency (chronic) (peripheral)
0.000 0.979 0.021
E21.3 Hyperparathyroidism, unspecified
0.000 0.979 0.021
G81 Hemiplegia
0.019 0.981 0.000
E04.2 Non-toxic multinodular goitre
0.000 0.981 0.019
E21.0 Primary hyperparathyroidism
0.000 0.981 0.018
I83.0 Varicose veins of lower extremities with ulcer
0.000 0.982 0.018
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.018 0.982 0.000
I87.1 Compression of vein
0.001 0.983 0.017
E83.5 Disorders of calcium metabolism
0.000 0.983 0.017
I69 Sequelae of cerebrovascular disease
0.017 0.983 0.000
I69.3 Sequelae of cerebral infarction
0.016 0.984 0.000
C44.4 Skin of scalp and neck
0.015 0.985 0.000
E66 Obesity
0.000 0.985 0.015
I69.0 Sequelae of subarachnoid haemorrhage
0.014 0.986 0.000
O48 Prolonged pregnancy
0.014 0.986 0.000
G81.0 Flaccid hemiplegia
0.014 0.986 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.014 0.986 0.000
G81.1 Spastic hemiplegia
0.013 0.987 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.013 0.987 0.000
C44.5 Skin of trunk
0.012 0.988 0.000
C44.6 Skin of upper limb, including shoulder
0.012 0.988 0.000
F00.9 Dementia in Alzheimer's disease, unspecified
0.012 0.988 0.000
C44 Other malignant neoplasms of skin
0.011 0.989 0.000
G30.9 Alzheimer's disease, unspecified
0.011 0.989 0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
0.011 0.989 0.000
E66.1 Drug-induced obesity
0.000 0.989 0.011
E83.4 Disorders of magnesium metabolism
0.000 0.989 0.011
G80.9 Infantile cerebral palsy, unspecified
0.011 0.989 0.000
G80 Infantile cerebral palsy
0.011 0.989 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.000 0.989 0.011
I86.1 Scrotal varices
0.001 0.989 0.010
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.010 0.990 0.000
F32.1 Moderate depressive episode
0.000 0.990 0.010
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.010 0.990 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.010 0.990 0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
0.010 0.990 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.990 0.009
E83.3 Disorders of phosphorus metabolism
0.001 0.990 0.009
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.991 0.009
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
0.009 0.991 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.991 0.009
G80.2 Infantile hemiplegia
0.009 0.991 0.000
F32.0 Mild depressive episode
0.000 0.991 0.009
F32 Depressive episode
0.000 0.991 0.009
G80.8 Other infantile cerebral palsy
0.009 0.991 0.000
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
0.009 0.991 0.000
F31.9 Bipolar affective disorder, unspecified
0.000 0.991 0.009
C44.8 Overlapping lesion of skin
0.008 0.992 0.000
C44.2 Skin of ear and external auricular canal
0.008 0.992 0.000
F30-F39 Mood [affective] disorders
0.000 0.992 0.008
C44.0 Skin of lip
0.008 0.992 0.000
F31 Bipolar affective disorder
0.000 0.992 0.008

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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