TreeWAS – Variant ID: rs2394251

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E10.9 Without complications	0.000	0.000	1.000
E83.1 Disorders of iron metabolism	1.000	0.000	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	0.000	0.000	1.000
L40.5 Arthropathic psoriasis	0.000	0.000	1.000
L40.9 Psoriasis, unspecified	0.000	0.000	1.000
L40 Psoriasis	0.000	0.001	0.999
I83 Varicose veins of lower extremities	0.997	0.003	0.000
E10.3 With ophthalmic complications	0.000	0.004	0.996
I71 Aortic aneurysm and dissection	0.994	0.006	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.993	0.007	0.000
K90.0 Coeliac disease	0.000	0.007	0.993
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.991	0.009	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.988	0.012	0.000
G35 Multiple sclerosis	0.988	0.012	0.000
Chapter IX Diseases of the circulatory system	0.988	0.012	0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.986	0.014	0.000
R41 Other symptoms and signs involving cognitive functions and awareness	0.985	0.015	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.984	0.016	0.000
E10.1 With ketoacidosis	0.000	0.021	0.979
Chapter VI Diseases of the nervous system	0.978	0.022	0.000
# Top node	0.977	0.023	0.000
R41.0 Disorientation, unspecified	0.977	0.023	0.000
Chapter V Mental and behavioural disorders	0.977	0.023	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.974	0.026	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.973	0.027	0.000
G40-G47 Episodic and paroxysmal disorders	0.969	0.031	0.000
G40 Epilepsy	0.966	0.034	0.000
R45 Symptoms and signs involving emotional state	0.961	0.039	0.000
R41.3 Other amnesia	0.953	0.047	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.951	0.049	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.922	0.058	0.020
E83 Disorders of mineral metabolism	0.942	0.058	0.000
R60.0 Localised oedema	0.930	0.070	0.000
R50-R69 General symptoms and signs	0.929	0.071	0.000
R60 Oedema, not elsewhere classified	0.927	0.073	0.000
F05 Delirium, not induced by alcohol and other psychoactive substances	0.926	0.074	0.000
R52 Pain, not elsewhere classified	0.926	0.074	0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.925	0.075	0.000
E70-E90 Metabolic disorders	0.918	0.082	0.000
R52.2 Other chronic pain	0.914	0.086	0.000
E10.4 With neurological complications	0.000	0.086	0.914
I85 Oesophageal varices	0.909	0.091	0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.909	0.091	0.000
E10.0 With coma	0.000	0.100	0.900
R79 Other abnormal findings of blood chemistry	0.900	0.100	0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures	0.899	0.101	0.000
F05.9 Delirium, unspecified	0.895	0.105	0.000
E10-E14 Diabetes mellitus	0.013	0.111	0.876
F60-F69 Disorders of adult personality and behaviour	0.888	0.112	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.883	0.117	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.883	0.117	0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.883	0.117	0.000
R79.8 Other specified abnormal findings of blood chemistry	0.879	0.121	0.000
F30-F39 Mood [affective] disorders	0.879	0.121	0.000
I72 Other aneurysm	0.877	0.123	0.000
R42 Dizziness and giddiness	0.874	0.126	0.000
G47 Sleep disorders	0.871	0.129	0.000
E10.2 With renal complications	0.000	0.133	0.867
F33 Recurrent depressive disorder	0.863	0.137	0.000
R41.2 Retrograde amnesia	0.859	0.141	0.000
E89.0 Postprocedural hypothyroidism	0.855	0.145	0.000
E14 Unspecified diabetes mellitus	0.001	0.147	0.852
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.852	0.148	0.000
R58 Haemorrhage, not elsewhere classified	0.850	0.150	0.000
F00 Dementia in Alzheimer's disease	0.841	0.159	0.000
R57 Shock, not elsewhere classified	0.841	0.159	0.000
G47.9 Sleep disorder, unspecified	0.840	0.160	0.000
E83.3 Disorders of phosphorus metabolism	0.835	0.165	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.835	0.165	0.000
E00-E07 Disorders of thyroid gland	0.828	0.169	0.003
I85.9 Oesophageal varices without bleeding	0.830	0.170	0.000
I83.1 Varicose veins of lower extremities with inflammation	0.830	0.170	0.000
R79.0 Abnormal level of blood mineral	0.828	0.172	0.000
F33.1 Recurrent depressive disorder, current episode moderate	0.826	0.174	0.000
R45.2 Unhappiness	0.821	0.178	0.000
R52.1 Chronic intractable pain	0.819	0.181	0.000
R45.1 Restlessness and agitation	0.818	0.181	0.000
Chapter XXII Codes for special purposes	0.818	0.182	0.000
F33.9 Recurrent depressive disorder, unspecified	0.813	0.187	0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset	0.812	0.188	0.000
I70 Atherosclerosis	0.810	0.190	0.000
G37 Other demyelinating diseases of central nervous system	0.810	0.190	0.000
G40.8 Other epilepsy	0.810	0.190	0.000
F60 Specific personality disorders	0.808	0.192	0.000
E14.3 With ophthalmic complications	0.000	0.193	0.807
I95-I99 Other and unspecified disorders of the circulatory system	0.807	0.193	0.000
F01 Vascular dementia	0.806	0.194	0.000
R45.6 Physical violence	0.805	0.195	0.000
I72.4 Aneurysm of artery of lower extremity	0.805	0.195	0.000
F07.0 Organic personality disorder	0.803	0.197	0.000
E04 Other non-toxic goitre	0.800	0.200	0.001
R45.4 Irritability and anger	0.795	0.205	0.000
I88 Nonspecific lymphadenitis	0.793	0.207	0.000
I80 Phlebitis and thrombophlebitis	0.792	0.208	0.000
E06 Thyroiditis	0.790	0.209	0.001
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.791	0.209	0.000
R77 Other abnormalities of plasma proteins	0.788	0.211	0.000
R52.0 Acute pain	0.786	0.214	0.000
G30-G32 Other degenerative diseases of the nervous system	0.785	0.215	0.000
R46 Symptoms and signs involving appearance and behaviour	0.781	0.219	0.000
R81 Glycosuria	0.779	0.221	0.000
G40.9 Epilepsy, unspecified	0.778	0.222	0.000
F05.0 Delirium not superimposed on dementia, so described	0.776	0.224	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.775	0.225	0.000
L40.0 Psoriasis vulgaris	0.000	0.227	0.773
R54 Senility	0.772	0.228	0.000
L40.1 Generalised pustular psoriasis	0.000	0.231	0.769
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.765	0.235	0.000
I74 Arterial embolism and thrombosis	0.764	0.236	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.763	0.237	0.000
I82 Other venous embolism and thrombosis	0.762	0.238	0.000
I05-I09 Chronic rheumatic heart diseases	0.762	0.238	0.000
I99 Other and unspecified disorders of circulatory system	0.762	0.238	0.000
E04.2 Non-toxic multinodular goitre	0.762	0.238	0.000
I86 Varicose veins of other sites	0.758	0.242	0.000
R45.0 Nervousness	0.758	0.242	0.000
L40.8 Other psoriasis	0.000	0.248	0.752
I71.1 Thoracic aortic aneurysm, ruptured	0.750	0.250	0.000
R43 Disturbances of smell and taste	0.749	0.251	0.000
F70-F79 Mental retardation	0.747	0.253	0.000
F03 Unspecified dementia	0.746	0.254	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.746	0.254	0.000
F00.0 Dementia in Alzheimer's disease with early onset	0.746	0.254	0.000
E04.9 Non-toxic goitre, unspecified	0.745	0.255	0.000
R82 Other abnormal findings in urine	0.744	0.255	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.742	0.258	0.000
R45.5 Hostility	0.741	0.259	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.739	0.261	0.000
I71.0 Dissection of aorta [any part]	0.738	0.262	0.000
F60.9 Personality disorder, unspecified	0.737	0.263	0.000
E10.6 With other specified complications	0.000	0.264	0.736
F80-F89 Disorders of psychological development	0.735	0.264	0.000
Chapter VIII Diseases of the ear and mastoid process	0.735	0.265	0.000
F02 Dementia in other diseases classified elsewhere	0.730	0.270	0.000
F69 Unspecified disorder of adult personality and behaviour	0.726	0.274	0.000
E06.3 Autoimmune thyroiditis	0.726	0.274	0.000
E65-E68 Obesity and other hyperalimentation	0.719	0.276	0.005
F29 Unspecified nonorganic psychosis	0.723	0.277	0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures	0.719	0.281	0.000
G43 Migraine	0.718	0.282	0.000
I85.0 Oesophageal varices with bleeding	0.717	0.283	0.000
E10.7 With multiple complications	0.000	0.283	0.717
G40.5 Special epileptic syndromes	0.717	0.283	0.000
L40.2 Acrodermatitis continua	0.000	0.283	0.716
G47.1 Disorders of excessive somnolence [hypersomnias]	0.714	0.286	0.000
R40 Somnolence, stupor and coma	0.712	0.287	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.712	0.288	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.712	0.288	0.000
G36 Other acute disseminated demyelination	0.710	0.290	0.000
R44 Other symptoms and signs involving general sensations and perceptions	0.710	0.290	0.000
G47.2 Disorders of the sleep-wake schedule	0.709	0.291	0.000
I00-I02 Acute rheumatic fever	0.708	0.292	0.000
G44 Other headache syndromes	0.708	0.292	0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs	0.707	0.293	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.706	0.294	0.000
R57.0 Cardiogenic shock	0.704	0.296	0.000
F33.0 Recurrent depressive disorder, current episode mild	0.704	0.296	0.000
Q23 Congenital malformations of aortic and mitral valves	0.704	0.296	0.000
R57.1 Hypovolaemic shock	0.701	0.299	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.701	0.299	0.000
G30 Alzheimer's disease	0.700	0.299	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.700	0.300	0.000
R46.8 Other symptoms and signs involving appearance and behaviour	0.700	0.300	0.000
I05 Rheumatic mitral valve diseases	0.700	0.300	0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.699	0.301	0.000
R95-R99 Ill-defined and unknown causes of mortality	0.698	0.302	0.000
E84 Cystic fibrosis	0.698	0.302	0.000
F09 Unspecified organic or symptomatic mental disorder	0.697	0.303	0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.697	0.303	0.000
F22 Persistent delusional disorders	0.696	0.304	0.000
R77.9 Abnormality of plasma protein, unspecified	0.693	0.307	0.000
G40.4 Other generalised epilepsy and epileptic syndromes	0.693	0.307	0.000
I72.3 Aneurysm of iliac artery	0.692	0.308	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.692	0.308	0.000
F39 Unspecified mood [affective] disorder	0.690	0.310	0.000
R45.3 Demoralisation and apathy	0.689	0.311	0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.687	0.313	0.000
F01.9 Vascular dementia, unspecified	0.686	0.314	0.000
E89.2 Postprocedural hypoparathyroidism	0.685	0.315	0.000
E14.9 Without complications	0.000	0.316	0.684
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.684	0.316	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.683	0.317	0.000
F07.2 Postconcussional syndrome	0.682	0.318	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.679	0.321	0.000
G06 Intracranial and intraspinal abscess and granuloma	0.678	0.322	0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.678	0.322	0.000
E14.5 With peripheral circulatory complications	0.001	0.323	0.677
E06.9 Thyroiditis, unspecified	0.676	0.324	0.000
G40.7 Petit mal, unspecified, without grand mal seizures	0.676	0.324	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.676	0.324	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.675	0.325	0.000
E83.8 Other disorders of mineral metabolism	0.675	0.325	0.000
E83.2 Disorders of zinc metabolism	0.675	0.325	0.000
E83.0 Disorders of copper metabolism	0.675	0.325	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.675	0.325	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.674	0.326	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.670	0.330	0.000
R45.8 Other symptoms and signs involving emotional state	0.668	0.332	0.000
H60-H62 Diseases of external ear	0.668	0.332	0.000
R45.7 State of emotional shock and stress, unspecified	0.666	0.334	0.000
R62 Lack of expected normal physiological development	0.666	0.334	0.000
F60.7 Dependent personality disorder	0.666	0.334	0.000
R71 Abnormality of red blood cells	0.664	0.336	0.000
I72.0 Aneurysm of carotid artery	0.663	0.337	0.000
Q23.1 Congenital insufficiency of aortic valve	0.663	0.337	0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]	0.662	0.338	0.000
G47.4 Narcolepsy and cataplexy	0.662	0.338	0.000
I82.9 Embolism and thrombosis of unspecified vein	0.660	0.340	0.000
E77 Disorders of glycoprotein metabolism	0.658	0.342	0.000
E76 Disorders of glycosaminoglycan metabolism	0.658	0.342	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.658	0.342	0.000
E72 Other disorders of amino-acid metabolism	0.658	0.342	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.658	0.342	0.000
E70 Disorders of aromatic amino-acid metabolism	0.658	0.342	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.658	0.342	0.000
G47.8 Other sleep disorders	0.658	0.342	0.000
R56 Convulsions, not elsewhere classified	0.657	0.343	0.000
F00.1 Dementia in Alzheimer's disease with late onset	0.657	0.343	0.000
R82.7 Abnormal findings on microbiological examination of urine	0.657	0.343	0.000
I88.0 Nonspecific mesenteric lymphadenitis	0.656	0.344	0.000
R57.2 Septic shock	0.656	0.344	0.000
F00.2 Dementia in Alzheimer's disease, atypical or mixed type	0.655	0.345	0.000
E65 Localised adiposity	0.653	0.345	0.002
L40.4 Guttate psoriasis	0.000	0.345	0.654
H80-H83 Diseases of inner ear	0.654	0.346	0.000
L40.3 Pustulosis palmaris et plantaris	0.000	0.347	0.653
R75 Laboratory evidence of human immunodeficiency virus [HIV]	0.651	0.348	0.000
E40-E46 Malnutrition	0.639	0.349	0.012
E13 Other specified diabetes mellitus	0.008	0.350	0.642
R77.0 Abnormality of albumin	0.645	0.355	0.000
E14.1 With ketoacidosis	0.001	0.355	0.644
E14.4 With neurological complications	0.001	0.356	0.643
E04.0 Non-toxic diffuse goitre	0.641	0.358	0.001
I82.3 Embolism and thrombosis of renal vein	0.640	0.360	0.000
R72 Abnormality of white blood cells, not elsewhere classified	0.639	0.361	0.000
G30.0 Alzheimer's disease with early onset	0.639	0.361	0.000
E12 Malnutrition-related diabetes mellitus	0.010	0.362	0.628
R52.9 Pain, unspecified	0.637	0.363	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.637	0.363	0.000
F68 Other disorders of adult personality and behaviour	0.636	0.363	0.000
F66 Psychological and behavioural disorders associated with sexual development and orientation	0.636	0.363	0.000
F65 Disorders of sexual preference	0.636	0.363	0.000
F63 Habit and impulse disorders	0.636	0.363	0.000
F61 Mixed and other personality disorders	0.636	0.363	0.000
H83 Other diseases of inner ear	0.635	0.365	0.000
I05.0 Mitral stenosis	0.634	0.366	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.633	0.367	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.633	0.367	0.000
E89.5 Postprocedural testicular hypofunction	0.633	0.367	0.000
E89.1 Postprocedural hypoinsulinaemia	0.633	0.367	0.000
F07.9 Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction	0.633	0.367	0.000
F07.8 Other organic personality and behavioural disorders due to brain disease, damage and dysfunction	0.633	0.367	0.000
F07.1 Postencephalitic syndrome	0.633	0.367	0.000
F60.5 Anankastic personality disorder	0.632	0.368	0.000
E14.8 With unspecified complications	0.001	0.369	0.630
F38 Other mood [affective] disorders	0.630	0.370	0.000
R44.1 Visual hallucinations	0.630	0.370	0.000
G41 Status epilepticus	0.629	0.371	0.000
R79.9 Abnormal finding of blood chemistry, unspecified	0.629	0.371	0.000
I72.6 Aneurysm and dissection of vertebral artery	0.628	0.371	0.000
I72.5 Aneurysm and dissection of other precerebral arteries	0.628	0.371	0.000
I72.1 Aneurysm of artery of upper extremity	0.628	0.371	0.000
I70.8 Atherosclerosis of other arteries	0.627	0.373	0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere	0.626	0.373	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.626	0.374	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.626	0.374	0.000
I72.9 Aneurysm of unspecified site	0.624	0.376	0.000
F62 Enduring personality changes, not attributable to brain damage and disease	0.624	0.376	0.000
Q25 Congenital malformations of great arteries	0.622	0.378	0.000
I74.0 Embolism and thrombosis of abdominal aorta	0.620	0.380	0.000
G06.1 Intraspinal abscess and granuloma	0.620	0.380	0.000
H83.0 Labyrinthitis	0.620	0.380	0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)	0.620	0.380	0.000
F33.8 Other recurrent depressive disorders	0.619	0.381	0.000
F33.4 Recurrent depressive disorder, currently in remission	0.619	0.381	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.619	0.381	0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.618	0.382	0.000
F55 Abuse of non-dependence-producing substances	0.618	0.382	0.000
F30 Manic episode	0.617	0.383	0.000
R40.2 Coma, unspecified	0.614	0.386	0.000
I74.8 Embolism and thrombosis of other arteries	0.613	0.387	0.000
F34 Persistent mood [affective] disorders	0.612	0.388	0.000
E14.7 With multiple complications	0.001	0.388	0.611
E14.2 Withrenal complications	0.001	0.388	0.611
E14.0 With coma	0.001	0.388	0.611
I86.4 Gastric varices	0.611	0.389	0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms	0.609	0.391	0.000
E89.4 Postprocedural ovarian failure	0.609	0.391	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.609	0.391	0.000
E74 Other disorders of carbohydrate metabolism	0.608	0.391	0.000
I70.1 Atherosclerosis of renal artery	0.608	0.392	0.000
Q27 Other congenital malformations of peripheral vascular system	0.608	0.392	0.000
R78 Findings of drugs and other substances, not normally found in blood	0.608	0.392	0.000
H61 Other disorders of external ear	0.607	0.393	0.000
R82.1 Myoglobinuria	0.606	0.393	0.000
E06.5 Other chronic thyroiditis	0.605	0.394	0.001
G43.1 Migraine with aura [classical migraine]	0.605	0.395	0.000
R43.0 Anosmia	0.605	0.395	0.000
F50 Eating disorders	0.605	0.395	0.000
R82.8 Abnormal findings on cytological and histological examination of urine	0.603	0.396	0.000
R57.8 Other shock	0.603	0.397	0.000
G44.0 Cluster headache syndrome	0.603	0.397	0.000
I86.2 Pelvic varices	0.601	0.398	0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.600	0.400	0.000
F22.0 Delusional disorder	0.599	0.401	0.000
F05.1 Delirium superimposed on dementia	0.599	0.401	0.000
R57.9 Shock, unspecified	0.598	0.402	0.000
R60.1 Generalised oedema	0.598	0.402	0.000
F51 Nonorganic sleep disorders	0.598	0.402	0.000
E14.6 With other specified complications	0.001	0.403	0.596
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.594	0.404	0.002
E00 Congenital iodine-deficiency syndrome	0.594	0.404	0.002
G20-G26 Extrapyramidal and movement disorders	0.595	0.405	0.000
E79 Disorders of purine and pyrimidine metabolism	0.594	0.405	0.000
F80 Specific developmental disorders of speech and language	0.593	0.407	0.000
R26 Abnormalities of gait and mobility	0.590	0.410	0.000
H61.2 Impacted cerumen	0.590	0.410	0.000
F64 Gender identity disorders	0.589	0.410	0.000
E10.8 With unspecified complications	0.000	0.411	0.588
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.588	0.412	0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.588	0.412	0.000
R27 Other lack of coordination	0.587	0.413	0.000
R77.1 Abnormality of globulin	0.586	0.414	0.000
U89 Agent resistant to other and unspecified antibiotics	0.584	0.416	0.000
F79 Unspecified mental retardation	0.582	0.418	0.000
G44.8 Other specified headache syndromes	0.582	0.418	0.000
R46.0 Very low level of personal hygiene	0.581	0.418	0.000
F02.8 Dementia in other specified diseases classified elsewhere	0.581	0.419	0.000
I70.9 Generalised and unspecified atherosclerosis	0.581	0.419	0.000
G37.5 Concentric sclerosis [Balo]	0.581	0.419	0.000
G37.4 Subacute necrotising myelitis	0.581	0.419	0.000
G37.2 Central pontine myelinolysis	0.581	0.419	0.000
G37.1 Central demyelination of corpus callosum	0.581	0.419	0.000
G37.0 Diffuse sclerosis	0.581	0.419	0.000
Q23.0 Congenital stenosis of aortic valve	0.580	0.420	0.000
F60.8 Other specific personality disorders	0.579	0.421	0.000
F60.4 Histrionic personality disorder	0.579	0.421	0.000
F60.2 Dissocial personality disorder	0.579	0.421	0.000
F60.1 Schizoid personality disorder	0.579	0.421	0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.579	0.421	0.000
E80.1 Porphyria cutanea tarda	0.579	0.421	0.000
U88 Agent resistant to multiple antibiotics	0.578	0.422	0.000
F01.8 Other vascular dementia	0.578	0.422	0.000
F01.3 Mixed cortical and subcortical vascular dementia	0.578	0.422	0.000
F01.2 Subcortical vascular dementia	0.578	0.422	0.000
F01.1 Multi-infarct dementia	0.578	0.422	0.000
F01.0 Vascular dementia of acute onset	0.578	0.422	0.000
F60.6 Anxious [avoidant] personality disorder	0.577	0.423	0.000
G06.2 Extradural and subdural abscess, unspecified	0.575	0.425	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.575	0.425	0.000
E04.8 Other specified non-toxic goitre	0.573	0.426	0.001
R64 Cachexia	0.573	0.427	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.573	0.427	0.000
I05.1 Rheumatic mitral insufficiency	0.572	0.428	0.000
Q24 Other congenital malformations of heart	0.572	0.428	0.000
G43.8 Other migraine	0.572	0.428	0.000
F60.0 Paranoid personality disorder	0.571	0.429	0.000
I86.8 Varicose veins of other specified sites	0.570	0.430	0.000
I88.8 Other nonspecific lymphadenitis	0.568	0.432	0.000
I88.1 Chronic lymphadenitis, except mesenteric	0.568	0.432	0.000
I06 Rheumatic aortic valve diseases	0.568	0.432	0.000
E06.4 Drug-induced thyroiditis	0.567	0.433	0.001
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.567	0.433	0.001
E06.1 Subacute thyroiditis	0.567	0.433	0.001
E06.0 Acute thyroiditis	0.567	0.433	0.001
F28 Other nonorganic psychotic disorders	0.567	0.433	0.000
F24 Induced delusional disorder	0.567	0.433	0.000
F21 Schizotypal disorder	0.567	0.433	0.000
I05.2 Mitral stenosis with insufficiency	0.567	0.433	0.000
R77.2 Abnormality of alphafetoprotein	0.565	0.435	0.000
Q00-Q07 Congenital malformations of the nervous system	0.564	0.436	0.000
R27.0 Ataxia, unspecified	0.563	0.437	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.562	0.438	0.000
I72.2 Aneurysm of renal artery	0.561	0.438	0.000
E73 Lactose intolerance	0.561	0.439	0.000
R46.7 Verbosity and circumstantial detail obscuring reason for contact	0.560	0.440	0.000
R46.6 Undue concern and preoccupation with stressful events	0.560	0.440	0.000
R46.5 Suspiciousness and marked evasiveness	0.560	0.440	0.000
R46.3 Overactivity	0.560	0.440	0.000
R46.1 Bizarre personal appearance	0.560	0.440	0.000
Q35-Q37 Cleft lip and cleft palate	0.559	0.440	0.000
R41.1 Anterograde amnesia	0.559	0.440	0.000
F22.9 Persistent delusional disorder, unspecified	0.559	0.441	0.000
I88.9 Nonspecific lymphadenitis, unspecified	0.559	0.441	0.000
I87 Other disorders of veins	0.559	0.441	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.558	0.442	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.556	0.442	0.001
G30.8 Other Alzheimer's disease	0.557	0.443	0.000
M45-M49 Spondylopathies	0.556	0.444	0.000
F53 Mental and behavioural disorders associated with the puerperium, not elsewhere classified	0.556	0.444	0.000
F59 Unspecified behavioural syndromes associated with physiological disturbances and physical factors	0.556	0.444	0.000
F54 Psychological and behavioural factors associated with disorders or diseases classified elsewhere	0.556	0.444	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.553	0.445	0.002
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity	0.555	0.445	0.000
F02.3 Dementia in Parkinson's disease	0.551	0.449	0.000
R82.4 Acetonuria	0.550	0.450	0.000
R26.0 Ataxic gait	0.550	0.450	0.000
R46.2 Strange and inexplicable behaviour	0.550	0.450	0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere	0.548	0.451	0.000
F05.8 Other delirium	0.548	0.452	0.000
I86.3 Vulval varices	0.548	0.452	0.000
M40-M43 Deforming dorsopathies	0.548	0.452	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.547	0.453	0.000
I82.1 Thrombophlebitis migrans	0.547	0.453	0.000
I82.0 Budd-Chiari syndrome	0.547	0.453	0.000
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere	0.544	0.456	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.544	0.456	0.000
G01 Meningitis in bacterial diseases classified elsewhere	0.543	0.456	0.000
I86.0 Sublingual varices	0.543	0.456	0.000
I89.0 Lymphoedema, not elsewhere classified	0.542	0.458	0.000
I72.8 Aneurysm of other specified arteries	0.541	0.459	0.000
E84.9 Cystic fibrosis, unspecified	0.541	0.459	0.000
G44.3 Chronic posttraumatic headache	0.540	0.460	0.000
R68 Other general symptoms and signs	0.540	0.460	0.000
R44.2 Other hallucinations	0.539	0.461	0.000
M86-M90 Other osteopathies	0.538	0.462	0.000
R43.2 Parageusia	0.537	0.463	0.000
R43.1 Parosmia	0.537	0.463	0.000
M41 Scoliosis	0.536	0.464	0.000
F78 Other mental retardation	0.536	0.464	0.000
F73 Profound mental retardation	0.536	0.464	0.000
F72 Severe mental retardation	0.536	0.464	0.000
F71 Moderate mental retardation	0.536	0.464	0.000
F70 Mild mental retardation	0.536	0.464	0.000
R82.6 Abnormal urine levels of substances chiefly nonmedicinal as to source	0.534	0.466	0.000
R82.5 Elevated urine levels of drugs, medicaments and biological substances	0.534	0.466	0.000
R82.3 Haemoglobinuria	0.534	0.466	0.000
R82.2 Biliuria	0.534	0.466	0.000
R82.0 Chyluria	0.534	0.466	0.000
M00-M03 Infectious arthropathies	0.532	0.468	0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere	0.532	0.468	0.000
M45 Ankylosing spondylitis	0.531	0.469	0.000
Q27.8 Other specified congenital malformations of peripheral vascular system	0.531	0.469	0.000
Q26 Congenital malformations of great veins	0.530	0.470	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.530	0.470	0.000
F06.2 Organic delusional [schizophrenia-like] disorder	0.529	0.471	0.000
M41.9 Scoliosis, unspecified	0.529	0.471	0.000
F11 Mental and behavioural disorders due to use of opioids	0.528	0.472	0.000
F89 Unspecified disorder of psychological development	0.527	0.473	0.000
F88 Other disorders of psychological development	0.527	0.473	0.000
F83 Mixed specific developmental disorders	0.527	0.473	0.000
F82 Specific developmental disorder of motor function	0.527	0.473	0.000
F81 Specific developmental disorders of scholastic skills	0.527	0.473	0.000
F02.4 Dementia in human immunodeficiency virus [HIV] disease	0.523	0.477	0.000
F02.2 Dementia in Huntington's disease	0.523	0.477	0.000
F02.1 Dementia in Creutzfeldt-Jakob disease	0.523	0.477	0.000
E80.6 Other disorders of bilirubin metabolism	0.523	0.477	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.520	0.480	0.000
E67 Other hyperalimentation	0.515	0.481	0.004
E68 Sequelae of hyperalimentation	0.515	0.481	0.004
F06.8 Other specified mental disorders due to brain damage and dysfunction and to physical disease	0.519	0.481	0.000
F14 Mental and behavioural disorders due to use of cocaine	0.518	0.482	0.000
M41.96 Scoliosis, unspecified (Lumbar region)	0.517	0.483	0.000
Q25.1 Coarctation of aorta	0.517	0.483	0.000
G43.3 Complicated migraine	0.515	0.485	0.000
G43.2 Status migrainosus	0.515	0.485	0.000
I07 Rheumatic tricuspid valve diseases	0.514	0.486	0.000
H61.8 Other specified disorders of external ear	0.514	0.486	0.000
R47-R49 Symptoms and signs involving speech and voice	0.514	0.486	0.000
G36.0 Neuromyelitis optica [Devic]	0.513	0.486	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.511	0.489	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.511	0.489	0.000
F06.7 Mild cognitive disorder	0.510	0.489	0.000
F30.0 Hypomania	0.510	0.490	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.509	0.491	0.000
G36.9 Acute disseminated demyelination, unspecified	0.509	0.491	0.000
G36.8 Other specified acute disseminated demyelination	0.509	0.491	0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.509	0.491	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.508	0.492	0.000
G04 Encephalitis, myelitis and encephalomyelitis	0.508	0.492	0.000
I02 Rheumatic chorea	0.508	0.492	0.000
I01 Rheumatic fever with heart involvement	0.508	0.492	0.000
I00 Rheumatic fever without mention of heart involvement	0.508	0.492	0.000
M00 Pyogenic arthritis	0.508	0.492	0.000
G44.1 Vascular headache, not elsewhere classified	0.507	0.492	0.000
U84 Resistance to other antimicrobial drugs	0.507	0.493	0.000
U83 Resistance to other antibiotics	0.507	0.493	0.000
U82 Resistance to betalactam antibiotics	0.507	0.493	0.000
U85 Resistance to antineoplastic drugs	0.507	0.493	0.000
Q21 Congenital malformations of cardiac septa	0.505	0.495	0.000
Q23.9 Congenital malformation of aortic and mitral valves, unspecified	0.505	0.495	0.000
Q23.8 Other congenital malformations of aortic and mitral valves	0.505	0.495	0.000
Q23.4 Hypoplastic left heart syndrome	0.505	0.495	0.000
Q23.3 Congenital mitral insufficiency	0.505	0.495	0.000
Q23.2 Congenital mitral stenosis	0.505	0.495	0.000
I70.0 Atherosclerosis of aorta	0.503	0.496	0.000
H62 Disorders of external ear in diseases classified elsewhere	0.503	0.497	0.000
P90-P96 Other disorders originating in the perinatal period	0.502	0.498	0.000
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn	0.502	0.498	0.000
P75-P78 Digestive system disorders of fetus and newborn	0.502	0.498	0.000
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn	0.502	0.498	0.000
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn	0.502	0.498	0.000
P35-P39 Infections specific to the perinatal period	0.502	0.498	0.000
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period	0.502	0.498	0.000
P10-P15 Birth trauma	0.502	0.498	0.000
P05-P08 Disorders related to length of gestation and fetal growth	0.502	0.498	0.000
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery	0.502	0.498	0.000
G30.1 Alzheimer's disease with late onset	0.502	0.498	0.000
F98 Other behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.502	0.498	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations