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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2395106
log Bayes Factor = 54.9559
Chromosome 6   position 32,193,220  (GRCh37) Explore rs2395106 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter X Diseases of the respiratory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
K51.9 Ulcerative colitis, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E50-E64 Other nutritional deficiencies
0.000 0.000 1.000
J40-J47 Chronic lower respiratory diseases
0.000 0.000 1.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
E27.1 Primary adrenocortical insufficiency
0.000 0.001 0.999
D86.9 Sarcoidosis, unspecified
0.000 0.001 0.999
Chapter I Certain infectious and parasitic diseases
0.000 0.001 0.999
D86 Sarcoidosis
0.000 0.001 0.999
D80-D89 Certain disorders involving the immune mechanism
0.000 0.001 0.999
M05 Seropositive rheumatoid arthritis
0.000 0.001 0.999
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.001 0.999
G35 Multiple sclerosis
0.000 0.001 0.999
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.001 0.999
M35 Other systemic involvement of connective tissue
0.000 0.002 0.998
E27 Other disorders of adrenal gland
0.000 0.002 0.998
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
K90 Intestinal malabsorption
0.000 0.002 0.998
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.002 0.998
J47 Bronchiectasis
0.000 0.002 0.998
B25-B34 Other viral diseases
0.000 0.003 0.997
M20-M25 Other joint disorders
0.000 0.003 0.997
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.003 0.997
A50-A64 Infections with a predominantly sexual mode of transmission
0.000 0.003 0.997
E20-E35 Disorders of other endocrine glands
0.000 0.004 0.996
K51 Ulcerative colitis
0.000 0.004 0.996
E53 Deficiency of other B group vitamins
0.000 0.006 0.994
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.000 0.006 0.994
Chapter XI Diseases of the digestive system
0.000 0.008 0.992
A63.0 Anogenital (venereal) warts
0.000 0.008 0.992
K90-K93 Other diseases of the digestive system
0.000 0.008 0.992
E55 Vitamin D deficiency
0.000 0.008 0.992
K50-K52 Noninfective enteritis and colitis
0.000 0.008 0.992
E55.9 Vitamin D deficiency, unspecified
0.000 0.014 0.986
E53.8 Deficiency of other specified B group vitamins
0.000 0.014 0.986
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.015 0.985
B25 Cytomegaloviral disease
0.000 0.016 0.984
B35-B49 Mycoses
0.000 0.018 0.982
J20-J22 Other acute lower respiratory infections
0.000 0.021 0.979
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.022 0.978
J33.0 Polyp of nasal cavity
0.000 0.022 0.978
J45 Asthma
0.000 0.022 0.978
J33 Nasal polyp
0.000 0.023 0.977
D50-D53 Nutritional anaemias
0.000 0.024 0.976
J30-J39 Other diseases of upper respiratory tract
0.000 0.024 0.976
B25.9 Cytomegaloviral disease, unspecified
0.000 0.026 0.974
E10-E14 Diabetes mellitus
0.000 0.028 0.972
J45.9 Asthma, unspecified
0.000 0.028 0.972
E10.9 Without complications
0.000 0.028 0.972
M34 Systemic sclerosis
0.000 0.028 0.972
E10 Insulin-dependent diabetes mellitus
0.000 0.028 0.972
J84 Other interstitial pulmonary diseases
0.000 0.029 0.971
B37 Candidiasis
0.000 0.033 0.967
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.037 0.963
B34 Viral infection of unspecified site
0.000 0.042 0.958
M31 Other necrotising vasculopathies
0.000 0.047 0.953
K51.8 Other ulcerative colitis
0.000 0.048 0.952
D50 Iron deficiency anaemia
0.000 0.052 0.948
B34.9 Viral infection, unspecified
0.000 0.058 0.942
B37.8 Candidiasis of other sites
0.000 0.063 0.937
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.071 0.929
D50.9 Iron deficiency anaemia, unspecified
0.000 0.074 0.926
M06.4 Inflammatory polyarthropathy
0.000 0.077 0.923
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.080 0.920
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.081 0.919
T50.9 Other and unspecified drugs, medicaments and biological substances
0.918 0.082 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.912 0.088 0.000
E04 Other non-toxic goitre
0.000 0.090 0.910
M34.9 Systemic sclerosis, unspecified
0.000 0.090 0.910
J22 Unspecified acute lower respiratory infection
0.000 0.091 0.909
T36-T50 Poisoning by drugs, medicaments and biological substances
0.907 0.093 0.000
J20 Acute bronchitis
0.000 0.101 0.899
K90.9 Intestinal malabsorption, unspecified
0.000 0.104 0.896
B37.0 Candidal stomatitis
0.000 0.112 0.888
J39 Other diseases of upper respiratory tract
0.000 0.114 0.886
D86.1 Sarcoidosis of lymph nodes
0.000 0.120 0.880
J33.9 Nasal polyp, unspecified
0.000 0.123 0.877
J44 Other chronic obstructive pulmonary disease
0.000 0.124 0.876
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.125 0.875
E06 Thyroiditis
0.000 0.129 0.871
B35 Dermatophytosis
0.000 0.129 0.871
Chapter VI Diseases of the nervous system
0.000 0.130 0.870
E53.9 Vitamin B deficiency, unspecified
0.000 0.130 0.870
M91-M94 Chondropathies
0.000 0.138 0.862
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.139 0.861
E27.2 Addisonian crisis
0.000 0.147 0.853
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.852 0.148 0.000
M35.1 Other overlap syndromes
0.000 0.149 0.851
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.847 0.153 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.155 0.845
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.159 0.841
B37.9 Candidiasis, unspecified
0.000 0.160 0.840
T46 Poisoning by agents primarily affecting the cardiovascular system
0.838 0.162 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.163 0.837
M31.6 Other giant cell arteritis
0.000 0.166 0.834
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.833 0.167 0.000
M34.8 Other forms of systemic sclerosis
0.000 0.168 0.832
E05.8 Other thyrotoxicosis
0.000 0.175 0.825
J81 Pulmonary oedema
0.000 0.175 0.825
E10.3 With ophthalmic complications
0.000 0.179 0.821
J44.8 Other specified chronic obstructive pulmonary disease
0.000 0.181 0.819
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.817 0.183 0.000
M31.3 Wegener's granulomatosis
0.000 0.184 0.816
M34.1 CR(E)ST syndrome
0.000 0.186 0.814
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.187 0.813
M12 Other specific arthropathies
0.000 0.190 0.810
M35.0 Sicca syndrome [Sjogren]
0.000 0.190 0.810
E10.2 With renal complications
0.000 0.191 0.809
B27 Infectious mononucleosis
0.000 0.191 0.809
T47.1 Other antacids and anti-gastric-secretion drugs
0.808 0.192 0.000
A60 Anogenital herpesviral [herpes simplex] infections
0.000 0.195 0.805
J39.8 Other specified diseases of upper respiratory tract
0.000 0.196 0.804
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.804 0.196 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.199 0.801
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.204 0.796
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.000 0.204 0.796
J20.9 Acute bronchitis, unspecified
0.000 0.204 0.796
M05.8 Other seropositive rheumatoid arthritis
0.000 0.205 0.795
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.206 0.793
E06.3 Autoimmune thyroiditis
0.000 0.209 0.791
M32 Systemic lupus erythematosus
0.000 0.211 0.789
D86.0 Sarcoidosis of lung
0.000 0.214 0.786
M93 Other osteochondropathies
0.000 0.214 0.786
E04.2 Non-toxic multinodular goitre
0.000 0.215 0.785
D53 Other nutritional anaemias
0.000 0.215 0.785
J32 Chronic sinusitis
0.000 0.217 0.783
M06.3 Rheumatoid nodule
0.000 0.220 0.780
J21 Acute bronchiolitis
0.000 0.222 0.778
M10 Gout
0.000 0.225 0.775
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.225 0.775
B35.1 Tinea unguium
0.000 0.227 0.773
D51 Vitamin B12 deficiency anaemia
0.000 0.230 0.770
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.231 0.769
T45.0 Antiallergic and antiemetic drugs
0.768 0.232 0.000
K51.0 Ulcerative (chronic) enterocolitis
0.000 0.234 0.766
J39.0 Retropharyngeal and parapharyngeal abscess
0.000 0.236 0.764
J46 Status asthmaticus
0.000 0.236 0.764
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.760 0.240 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.758 0.241 0.000
E56 Other vitamin deficiencies
0.000 0.242 0.758
J20.8 Acute bronchitis due to other specified organisms
0.000 0.242 0.758
E34 Other endocrine disorders
0.000 0.246 0.754
E07 Other disorders of thyroid
0.000 0.248 0.752
E04.9 Non-toxic goitre, unspecified
0.000 0.251 0.749
B36 Other superficial mycoses
0.000 0.256 0.744
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.256 0.744
B85-B89 Pediculosis, acariasis and other infestations
0.000 0.259 0.741
J40 Bronchitis, not specified as acute or chronic
0.000 0.259 0.741
E20 Hypoparathyroidism
0.000 0.260 0.739
T46.4 Angiotensin-converting-enzyme inhibitors
0.738 0.262 0.000
E10.6 With other specified complications
0.000 0.262 0.738
J32.0 Chronic maxillary sinusitis
0.000 0.262 0.738
K51.1 Ulcerative (chronic) ileocolitis
0.000 0.262 0.738
J84.8 Other specified interstitial pulmonary diseases
0.000 0.263 0.737
B37.7 Candidal septicaemia
0.000 0.263 0.737
E10.0 With coma
0.000 0.264 0.736
K51.3 Ulcerative (chronic) rectosigmoiditis
0.000 0.264 0.736
M31.0 Hypersensitivity angiitis
0.000 0.265 0.735
E10.1 With ketoacidosis
0.000 0.266 0.734
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.267 0.733
M93.9 Osteochondropathy, unspecified
0.000 0.269 0.731
D86.8 Sarcoidosis of other and combined sites
0.000 0.270 0.730
B34.8 Other viral infections of unspecified site
0.000 0.271 0.729
E29 Testicular dysfunction
0.000 0.272 0.728
J95-J99 Other diseases of the respiratory system
0.000 0.273 0.727
E25 Adrenogenital disorders
0.000 0.275 0.725
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.278 0.722
B37.2 Candidiasis of skin and nail
0.000 0.279 0.721
E03.1 Congenital hypothyroidism without goitre
0.000 0.279 0.720
A52 Late syphilis
0.000 0.280 0.720
B25.8 Other cytomegaloviral diseases
0.000 0.282 0.718
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.283 0.717
E63 Other nutritional deficiencies
0.000 0.283 0.717
E50 Vitamin A deficiency
0.000 0.283 0.717
E60 Dietary zinc deficiency
0.000 0.283 0.717
E59 Dietary selenium deficiency
0.000 0.283 0.717
E52 Niacin deficiency [pellagra]
0.000 0.283 0.717
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.000 0.283 0.716
A75-A79 Rickettsioses
0.000 0.283 0.716
A70-A74 Other diseases caused by chlamydiae
0.000 0.283 0.716
D81 Combined immunodeficiencies
0.000 0.284 0.716
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.284 0.716
M05.2 Rheumatoid vasculitis
0.000 0.284 0.716
M05.1 Rheumatoid lung disease
0.000 0.284 0.716
M05.0 Felty's syndrome
0.000 0.284 0.716
M08 Juvenile arthritis
0.000 0.284 0.716
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.284 0.716
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.284 0.716
M35.5 Multifocal fibrosclerosis
0.000 0.284 0.716
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.284 0.716
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.716 0.284 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.284 0.716
E27.0 Other adrenocortical overactivity
0.000 0.284 0.716
K90.3 Pancreatic steatorrhoea
0.000 0.284 0.715
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.284 0.715
K90.1 Tropical sprue
0.000 0.284 0.715
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.285 0.715
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.285 0.715
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.285 0.715
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.285 0.715
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.285 0.715
B30 Viral conjunctivitis
0.000 0.285 0.715
B26 Mumps
0.000 0.285 0.715
M35.8 Other specified systemic involvement of connective tissue
0.000 0.285 0.715
A59 Trichomoniasis
0.000 0.285 0.714
A56 Other sexually transmitted chlamydial diseases
0.000 0.285 0.714
A54 Gonococcal infection
0.000 0.285 0.714
A53 Other and unspecified syphilis
0.000 0.285 0.714
A51 Early syphilis
0.000 0.285 0.714
A50 Congenital syphilis
0.000 0.285 0.714
A64 Unspecified sexually transmitted disease
0.000 0.285 0.714
A58 Granuloma inguinale
0.000 0.285 0.714
A57 Chancroid
0.000 0.285 0.714
A55 Chlamydial lymphogranuloma (venereum)
0.000 0.285 0.714
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.286 0.714
E32 Diseases of thymus
0.000 0.286 0.714
E31 Polyglandular dysfunction
0.000 0.286 0.714
E30 Disorders of puberty, not elsewhere classified
0.000 0.286 0.714
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.286 0.714
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.714 0.286 0.000
D55-D59 Haemolytic anaemias
0.000 0.287 0.713
E53.1 Pyridoxine deficiency
0.000 0.287 0.713
E53.0 Riboflavin deficiency
0.000 0.287 0.713
A63.8 Other specified predominantly sexually transmitted diseases
0.000 0.287 0.712
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.289 0.711
E55.0 Rickets, active
0.000 0.289 0.711
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.710 0.290 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.710 0.290 0.000
M00-M03 Infectious arthropathies
0.000 0.291 0.709
M22 Disorders of patella
0.000 0.293 0.707
B33 Other viral diseases, not elsewhere classified
0.000 0.293 0.706
B35.6 Tinea cruris
0.000 0.294 0.706
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.294 0.705
B25.2 Cytomegaloviral pancreatitis
0.000 0.295 0.705
B25.1 Cytomegaloviral hepatitis
0.000 0.295 0.705
B25.0 Cytomegaloviral pneumonitis
0.000 0.295 0.705
B48 Other mycoses, not elsewhere classified
0.000 0.296 0.704
B47 Mycetoma
0.000 0.296 0.704
B46 Zygomycosis
0.000 0.296 0.704
B45 Cryptococcosis
0.000 0.296 0.704
B43 Chromomycosis and phaeomycotic abscess
0.000 0.296 0.704
B42 Sporotrichosis
0.000 0.296 0.704
B41 Paracoccidioidomycosis
0.000 0.296 0.704
B40 Blastomycosis
0.000 0.296 0.704
B39 Histoplasmosis
0.000 0.296 0.704
B38 Coccidioidomycosis
0.000 0.296 0.704
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.000 0.296 0.704
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.296 0.704
M31.7 Microscopic polyangiitis
0.000 0.297 0.703
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.298 0.702
E51 Thiamine deficiency
0.000 0.302 0.698
E12 Malnutrition-related diabetes mellitus
0.000 0.303 0.697
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.303 0.697
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.303 0.697
M34.0 Progressive systemic sclerosis
0.000 0.303 0.697
E10.7 With multiple complications
0.000 0.303 0.697
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.304 0.696
T50.8 Diagnostic agents
0.695 0.305 0.000
D82 Immunodeficiency associated with other major defects
0.000 0.306 0.694
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.307 0.693
B37.6 Candidal endocarditis
0.000 0.307 0.693
B37.5 Candidal meningitis
0.000 0.307 0.693
E54 Ascorbic acid deficiency
0.000 0.307 0.693
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.307 0.693
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.691 0.309 0.000
K35-K38 Diseases of appendix
0.000 0.309 0.691
J43 Emphysema
0.000 0.309 0.691
E61 Deficiency of other nutrient elements
0.000 0.311 0.689
E26 Hyperaldosteronism
0.000 0.311 0.688
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.312 0.688
A15-A19 Tuberculosis
0.000 0.312 0.688
A65-A69 Other spirochaetal diseases
0.000 0.313 0.687
B34.3 Parvovirus infection, unspecified
0.000 0.313 0.687
B34.2 Coronavirus infection, unspecified
0.000 0.313 0.687
B34.0 Adenovirus infection, unspecified
0.000 0.313 0.687
J34 Other disorders of nose and nasal sinuses
0.000 0.313 0.687
G00-G09 Inflammatory diseases of the central nervous system
0.000 0.313 0.687
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.315 0.685
M31.8 Other specified necrotising vasculopathies
0.000 0.316 0.683
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.316 0.683
M31.2 Lethal midline granuloma
0.000 0.316 0.683
B50-B64 Protozoal diseases
0.000 0.318 0.682
J84.0 Alveolar and parietoalveolar conditions
0.000 0.319 0.681
D50.1 Sideropenic dysphagia
0.000 0.321 0.679
J45.8 Mixed asthma
0.000 0.321 0.679
B90-B94 Sequelae of infectious and parasitic diseases
0.000 0.321 0.679
K70-K77 Diseases of liver
0.000 0.325 0.675
M06.0 Seronegative rheumatoid arthritis
0.000 0.326 0.674
B27.9 Infectious mononucleosis, unspecified
0.000 0.326 0.674
M10.0 Idiopathic gout
0.000 0.327 0.673
M22.2 Patellofemoral disorders
0.000 0.327 0.673
B99-B99 Other infectious diseases
0.000 0.327 0.673
M30 Polyarteritis nodosa and related conditions
0.000 0.329 0.671
D84 Other immunodeficiencies
0.000 0.331 0.669
K75 Other inflammatory liver diseases
0.000 0.332 0.668
A60.0 Herpesviral infection of genitalia and urogenital tract
0.000 0.332 0.667
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.333 0.667
D52 Folate deficiency anaemia
0.000 0.333 0.667
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.334 0.666
M12.3 Palindromic rheumatism
0.000 0.334 0.666
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.338 0.662
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.338 0.662
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.338 0.662
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.338 0.662
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.338 0.662
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.338 0.662
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.338 0.662
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.338 0.662
J39.9 Disease of upper respiratory tract, unspecified
0.000 0.338 0.662
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.657 0.343 0.000
D50.8 Other iron deficiency anaemias
0.000 0.343 0.657
E06.9 Thyroiditis, unspecified
0.000 0.344 0.656
M91 Juvenile osteochondrosis of hip and pelvis
0.000 0.345 0.655
G37 Other demyelinating diseases of central nervous system
0.000 0.345 0.655
B37.4 Candidiasis of other urogenital sites
0.000 0.345 0.655
T42.3 Barbiturates
0.654 0.345 0.000
T50.7 Analeptics and opioid receptor antagonists
0.654 0.346 0.000
T50.5 Appetite depressants
0.654 0.346 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.654 0.346 0.000
T50.1 Loop [high-ceiling] diuretics
0.654 0.346 0.000
T50.0 Mineralocorticoids and their antagonists
0.654 0.346 0.000
E04.8 Other specified non-toxic goitre
0.000 0.347 0.652
K75.4 Autoimmune hepatitis
0.000 0.349 0.651
E34.0 Carcinoid syndrome
0.000 0.349 0.651
T41 Poisoning by anaesthetics and therapeutic gases
0.650 0.350 0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.000 0.350 0.650
E06.1 Subacute thyroiditis
0.000 0.352 0.648
D53.9 Nutritional anaemia, unspecified
0.000 0.353 0.647
T50.4 Drugs affecting uric acid metabolism
0.646 0.353 0.000
J20.7 Acute bronchitis due to echovirus
0.000 0.355 0.645
J20.6 Acute bronchitis due to rhinovirus
0.000 0.355 0.645
J20.5 Acute bronchitis due to respiratory syncytial virus
0.000 0.355 0.645
J20.4 Acute bronchitis due to parainfluenza virus
0.000 0.355 0.645
J20.3 Acute bronchitis due to coxsackie virus
0.000 0.355 0.645
J20.2 Acute bronchitis due to streptococcus
0.000 0.355 0.645
J20.1 Acute bronchitis due to Haemophilus influenzae
0.000 0.355 0.645
J20.0 Acute bronchitis due to Mycoplasma pneumoniae
0.000 0.355 0.645
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.000 0.356 0.644
T47.4 Other laxatives
0.642 0.358 0.000
D83 Common variable immunodeficiency
0.000 0.359 0.641
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.360 0.640
E58 Dietary calcium deficiency
0.000 0.361 0.639
J99 Respiratory disorders in diseases classified elsewhere
0.000 0.362 0.638
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.637 0.363 0.000
J37 Chronic laryngitis and laryngotracheitis
0.000 0.363 0.637
K75.8 Other specified inflammatory liver diseases
0.000 0.364 0.636
J80 Adult respiratory distress syndrome
0.000 0.364 0.636
T42.0 Hydantoin derivatives
0.636 0.364 0.000
J39.3 Upper respiratory tract hypersensitivity reaction, site unspecified
0.000 0.365 0.635
J21.9 Acute bronchiolitis, unspecified
0.000 0.366 0.634
M35.2 Behcet's disease
0.000 0.368 0.632
M31.1 Thrombotic microangiopathy
0.000 0.369 0.630
J45.1 Nonallergic asthma
0.000 0.370 0.630
J34.3 Hypertrophy of nasal turbinates
0.000 0.375 0.625
E06.4 Drug-induced thyroiditis
0.000 0.375 0.625
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.375 0.625
E06.0 Acute thyroiditis
0.000 0.375 0.625
B35.8 Other dermatophytoses
0.000 0.375 0.624
B35.5 Tinea imbricata
0.000 0.375 0.624
B35.4 Tinea corporis
0.000 0.375 0.624
B35.2 Tinea manuum
0.000 0.375 0.624
B35.0 Tinea barbae and tinea capitis
0.000 0.375 0.624
T42.4 Benzodiazepines
0.621 0.379 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.620 0.380 0.000
B44 Aspergillosis
0.000 0.381 0.619
G36 Other acute disseminated demyelination
0.000 0.381 0.618
J39.1 Other abscess of pharynx
0.000 0.382 0.618
D86.3 Sarcoidosis of skin
0.000 0.383 0.617
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.617 0.383 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.383 0.617
J41 Simple and mucopurulent chronic bronchitis
0.000 0.383 0.617
T36 Poisoning by systemic antibiotics
0.616 0.384 0.000
K73 Chronic hepatitis, not elsewhere classified
0.000 0.385 0.615
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.615 0.385 0.000
K37 Unspecified appendicitis
0.000 0.387 0.613
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.611 0.389 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.611 0.389 0.000
T47.7 Emetics
0.611 0.389 0.000
T47.6 Antidiarrhoeal drugs
0.611 0.389 0.000
T47.5 Digestants
0.611 0.389 0.000
T47.3 Saline and osmotic laxatives
0.611 0.389 0.000
T47.2 Stimulant laxatives
0.611 0.389 0.000
T47.0 Histamine H(2)-receptor antagonists
0.611 0.389 0.000
E07.8 Other specified disorders of thyroid
0.000 0.390 0.610
J33.1 Polypoid sinus degeneration
0.000 0.391 0.608
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.607 0.393 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.607 0.393 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.607 0.393 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.607 0.393 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.607 0.393 0.000
T44.0 Anticholinesterase agents
0.607 0.393 0.000
J32.9 Chronic sinusitis, unspecified
0.000 0.394 0.606
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.605 0.395 0.000
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.395 0.605
J43.8 Other emphysema
0.000 0.398 0.602
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.601 0.399 0.000
A20-A28 Certain zoonotic bacterial diseases
0.000 0.399 0.601
B35.3 Tinea pedis
0.000 0.399 0.601
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.601 0.399 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.601 0.399 0.000
T46.7 Peripheral vasodilators
0.601 0.399 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.601 0.399 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.399 0.601
M10.07 Idiopathic gout (Ankle and foot)
0.000 0.399 0.601
B34.1 Enterovirus infection, unspecified
0.000 0.400 0.600
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.599 0.401 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.597 0.402 0.000
T45.8 Other primarily systemic and haematological agents
0.597 0.402 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.597 0.402 0.000
T45.6 Fibrinolysis-affecting drugs
0.597 0.402 0.000
T45.4 Iron and its compounds
0.597 0.402 0.000
T45.3 Enzymes, not elsewhere classified
0.597 0.402 0.000
M94 Other disorders of cartilage
0.000 0.403 0.597
B35.9 Dermatophytosis, unspecified
0.000 0.403 0.597
M12.2 Villonodular synovitis (pigmented)
0.000 0.405 0.595
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.406 0.594
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.406 0.594
K51.5 Mucosal proctocolitis
0.000 0.407 0.593
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.407 0.593
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.591 0.409 0.000
D67 Hereditary factor IX deficiency
0.000 0.410 0.590
T42.5 Mixed antiepileptics, not elsewhere classified
0.586 0.414 0.000
T42.2 Succinimides and oxazolidinediones
0.586 0.414 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.414 0.585
E56.1 Deficiency of vitamin K
0.000 0.415 0.585
G09 Sequelae of inflammatory diseases of central nervous system
0.000 0.416 0.584
J32.3 Chronic sphenoidal sinusitis
0.000 0.417 0.583
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.582 0.418 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.418 0.582
M12.8 Other specific arthropathies, not elsewhere classified
0.000 0.419 0.581
M12.5 Traumatic arthropathy
0.000 0.419 0.581
M12.4 Intermittent hydrarthrosis
0.000 0.419 0.581
M12.1 Kaschin-Beck disease
0.000 0.419 0.581
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.000 0.419 0.581
M31.9 Necrotising vasculopathy, unspecified
0.000 0.420 0.580
D68 Other coagulation defects
0.000 0.420 0.580
B27.8 Other infectious mononucleosis
0.000 0.420 0.580
B27.1 Cytomegaloviral mononucleosis
0.000 0.420 0.580
B27.0 Gammaherpesviral mononucleosis
0.000 0.420 0.580
J86 Pyothorax
0.000 0.421 0.579
T46.5 Other antihypertensive drugs, not elsewhere classified
0.578 0.421 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.578 0.422 0.000
A60.9 Anogenital herpesviral infection, unspecified
0.000 0.423 0.577
A60.1 Herpesviral infection of perianal skin and rectum
0.000 0.423 0.577
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.423 0.577
B65-B83 Helminthiases
0.000 0.425 0.575
J34.0 Abscess, furuncle and carbuncle of nose
0.000 0.425 0.575
E29.1 Testicular hypofunction
0.000 0.425 0.575
B36.9 Superficial mycosis, unspecified
0.000 0.426 0.574
M02 Reactive arthropathies
0.000 0.427 0.573
G11 Hereditary ataxia
0.000 0.427 0.573
B07 Viral warts
0.000 0.427 0.573
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.000 0.430 0.570
M05.88 Other seropositive rheumatoid arthritis (Other)
0.000 0.430 0.570
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.000 0.430 0.570
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.000 0.430 0.570
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.000 0.430 0.570
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.000 0.430 0.570
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.000 0.430 0.570
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.000 0.430 0.570
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.000 0.430 0.570
M06.34 Rheumatoid nodule (Hand)
0.000 0.432 0.568
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.432 0.568
T48.6 Antiasthmatics, not elsewhere classified
0.568 0.432 0.000
T38.8 Other and unspecified hormones and their synthetic substitutes
0.567 0.433 0.000
M32.9 Systemic lupus erythematosus, unspecified
0.000 0.434 0.566
M32.8 Other forms of systemic lupus erythematosus
0.000 0.434 0.566
M32.0 Drug-induced systemic lupus erythematosus
0.000 0.434 0.566
J32.8 Other chronic sinusitis
0.000 0.435 0.565
J34.1 Cyst and mucocele of nose and nasal sinus
0.000 0.436 0.564
M45-M49 Spondylopathies
0.000 0.436 0.564
M93.8 Other specified osteochondropathies
0.000 0.437 0.563
M93.2 Osteochondritis dissecans
0.000 0.437 0.563
M93.1 Kienbock's disease of adults
0.000 0.437 0.563
M93.0 Slipped upper femoral epiphysis (nontraumatic)
0.000 0.437 0.563

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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