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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2395150
log Bayes Factor = 194.768
Chromosome 6   position 32,326,045  (GRCh37) Explore rs2395150 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E14.3 With ophthalmic complications
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
J33.0 Polyp of nasal cavity
0.000 0.000 1.000
J33 Nasal polyp
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.001 0.999
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
M07 Psoriatic and enteropathic arthropathies
0.000 0.001 0.999
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.001 0.999
L40.5 Arthropathic psoriasis
0.000 0.001 0.999
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.002 0.998
M07.3 Other psoriatic arthropathies
0.000 0.002 0.998
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
# Top node
0.000 0.002 0.998
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.002 0.998
M35.3 Polymyalgia rheumatica
0.000 0.003 0.997
J45 Asthma
0.000 0.004 0.996
E10.4 With neurological complications
0.000 0.004 0.996
Chapter X Diseases of the respiratory system
0.000 0.004 0.996
J40-J47 Chronic lower respiratory diseases
0.000 0.004 0.996
G35-G37 Demyelinating diseases of the central nervous system
0.996 0.004 0.000
Chapter VII Diseases of the eye and adnexa
0.000 0.004 0.996
G37 Other demyelinating diseases of central nervous system
0.995 0.005 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.994 0.006 0.000
J33.9 Nasal polyp, unspecified
0.000 0.008 0.992
L40-L45 Papulosquamous disorders
0.000 0.009 0.991
E11.1 With ketoacidosis
0.000 0.009 0.991
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.010 0.990
M35 Other systemic involvement of connective tissue
0.000 0.010 0.990
E10.2 With renal complications
0.000 0.013 0.987
M20-M25 Other joint disorders
0.000 0.014 0.986
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.015 0.985
J43 Emphysema
0.000 0.022 0.978
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.022 0.978
M06.3 Rheumatoid nodule
0.000 0.023 0.977
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.025 0.975
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.026 0.974
E10.5 With peripheral circulatory complications
0.000 0.029 0.971
J30-J39 Other diseases of upper respiratory tract
0.000 0.032 0.968
H33 Retinal detachments and breaks
0.000 0.032 0.968
E10.0 With coma
0.000 0.042 0.958
J33.8 Other polyp of sinus
0.000 0.042 0.958
H33.3 Retinal breaks without detachment
0.000 0.045 0.955
E11.3 With ophthalmic complications
0.000 0.048 0.952
L40.0 Psoriasis vulgaris
0.000 0.049 0.951
M06.4 Inflammatory polyarthropathy
0.000 0.055 0.945
J43.9 Emphysema, unspecified
0.000 0.058 0.942
M31 Other necrotising vasculopathies
0.000 0.073 0.927
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.078 0.922
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.081 0.919
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.083 0.917
J95-J99 Other diseases of the respiratory system
0.000 0.086 0.914
H53-H54 Visual disturbances and blindness
0.000 0.086 0.914
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.088 0.912
H33.4 Traction detachment of retina
0.000 0.089 0.911
E10.8 With unspecified complications
0.000 0.091 0.909
K90 Intestinal malabsorption
0.000 0.096 0.904
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.103 0.897
E06 Thyroiditis
0.000 0.107 0.893
M35.1 Other overlap syndromes
0.000 0.107 0.893
E70-E90 Metabolic disorders
0.000 0.107 0.892
H54 Blindness and low vision
0.000 0.108 0.892
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.114 0.886
E10.6 With other specified complications
0.000 0.117 0.883
J95.0 Tracheostomy malfunction
0.000 0.119 0.881
M31.6 Other giant cell arteritis
0.000 0.120 0.880
E50-E64 Other nutritional deficiencies
0.000 0.123 0.877
H34 Retinal vascular occlusions
0.000 0.124 0.876
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.130 0.870
L80 Vitiligo
0.000 0.130 0.870
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.134 0.866
E11.2 With renal complications
0.000 0.139 0.861
M65-M68 Disorders of synovium and tendon
0.000 0.139 0.861
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.140 0.860
K90-K93 Other diseases of the digestive system
0.000 0.140 0.860
Chapter XI Diseases of the digestive system
0.000 0.141 0.859
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.142 0.858
E11.8 With unspecified complications
0.000 0.145 0.855
M06.34 Rheumatoid nodule (Hand)
0.000 0.151 0.849
E14.6 With other specified complications
0.000 0.153 0.847
J86 Pyothorax
0.000 0.154 0.846
G37.8 Other specified demyelinating diseases of central nervous system
0.842 0.158 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.158 0.842
E53 Deficiency of other B group vitamins
0.000 0.159 0.841
E03.8 Other specified hypothyroidism
0.000 0.159 0.841
H35 Other retinal disorders
0.000 0.161 0.839
K70-K77 Diseases of liver
0.000 0.162 0.838
J43.2 Centrilobular emphysema
0.000 0.162 0.838
K75 Other inflammatory liver diseases
0.000 0.162 0.838
E14.1 With ketoacidosis
0.000 0.162 0.838
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.164 0.836
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.166 0.834
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.167 0.833
E14.8 With unspecified complications
0.000 0.167 0.833
E86 Volume depletion
0.000 0.168 0.832
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.168 0.832
L40.8 Other psoriasis
0.000 0.169 0.831
K75.4 Autoimmune hepatitis
0.000 0.169 0.831
M12 Other specific arthropathies
0.000 0.169 0.831
L40.1 Generalised pustular psoriasis
0.000 0.171 0.829
E53.8 Deficiency of other specified B group vitamins
0.000 0.175 0.825
E16.1 Other hypoglycaemia
0.000 0.175 0.825
D64.9 Anaemia, unspecified
0.000 0.176 0.824
H54.7 Unspecified visual loss
0.000 0.177 0.823
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.178 0.822
D60-D64 Aplastic and other anaemias
0.000 0.180 0.820
D64 Other anaemias
0.000 0.181 0.819
E88 Other metabolic disorders
0.000 0.183 0.817
K75.8 Other specified inflammatory liver diseases
0.000 0.185 0.815
H54.0 Blindness, both eyes
0.000 0.188 0.812
L90 Atrophic disorders of skin
0.000 0.192 0.808
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.193 0.807
M34 Systemic sclerosis
0.000 0.193 0.807
E83.1 Disorders of iron metabolism
0.806 0.194 0.000
H35.4 Peripheral retinal degeneration
0.000 0.197 0.803
M80-M85 Disorders of bone density and structure
0.000 0.198 0.802
M45-M49 Spondylopathies
0.000 0.202 0.798
K73 Chronic hepatitis, not elsewhere classified
0.000 0.207 0.793
H35.8 Other specified retinal disorders
0.000 0.208 0.792
E14.2 Withrenal complications
0.000 0.208 0.792
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.209 0.791
L10-L14 Bullous disorders
0.000 0.209 0.791
E06.3 Autoimmune thyroiditis
0.000 0.210 0.790
J43.8 Other emphysema
0.000 0.211 0.788
E78.2 Mixed hyperlipidaemia
0.000 0.213 0.787
L90.0 Lichen sclerosus et atrophicus
0.000 0.220 0.780
J39 Other diseases of upper respiratory tract
0.000 0.221 0.779
M80 Osteoporosis with pathological fracture
0.000 0.221 0.779
J46 Status asthmaticus
0.000 0.222 0.778
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.224 0.776
L40.3 Pustulosis palmaris et plantaris
0.000 0.225 0.775
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.229 0.771
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.230 0.770
G36 Other acute disseminated demyelination
0.768 0.232 0.000
E78.4 Other hyperlipidaemia
0.000 0.232 0.768
M65 Synovitis and tenosynovitis
0.000 0.235 0.765
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.236 0.764
J86.0 Pyothorax with fistula
0.000 0.237 0.763
J33.1 Polypoid sinus degeneration
0.000 0.239 0.761
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.239 0.761
D50-D53 Nutritional anaemias
0.000 0.242 0.758
M45 Ankylosing spondylitis
0.000 0.245 0.755
M24 Other specific joint derangements
0.000 0.247 0.753
E83 Disorders of mineral metabolism
0.725 0.247 0.029
M30 Polyarteritis nodosa and related conditions
0.000 0.247 0.753
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.251 0.749
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.253 0.747
H43-H45 Disorders of vitreous body and globe
0.000 0.254 0.746
M35.7 Hypermobility syndrome
0.000 0.255 0.745
E20-E35 Disorders of other endocrine glands
0.000 0.255 0.745
E27 Other disorders of adrenal gland
0.000 0.256 0.744
E89.0 Postprocedural hypothyroidism
0.000 0.258 0.742
J86.9 Pyothorax without fistula
0.000 0.258 0.742
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.741 0.259 0.000
H54.2 Low vision, both eyes
0.000 0.260 0.740
M86-M90 Other osteopathies
0.000 0.263 0.737
M35.2 Behcet's disease
0.000 0.265 0.735
E27.1 Primary adrenocortical insufficiency
0.000 0.267 0.733
J20-J22 Other acute lower respiratory infections
0.000 0.271 0.729
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.000 0.272 0.728
L94 Other localised connective tissue disorders
0.000 0.272 0.728
H34.9 Retinal vascular occlusion, unspecified
0.000 0.274 0.726
K90.9 Intestinal malabsorption, unspecified
0.000 0.274 0.726
E40-E46 Malnutrition
0.000 0.276 0.724
J99 Respiratory disorders in diseases classified elsewhere
0.000 0.277 0.723
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.284 0.716
M07.5 Arthropathy in ulcerative colitis
0.000 0.284 0.716
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.284 0.716
M07.2 Psoriatic spondylitis
0.000 0.284 0.716
M07.1 Arthritis mutilans
0.000 0.284 0.716
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.284 0.716
D50 Iron deficiency anaemia
0.000 0.284 0.716
M07.38 Other psoriatic arthropathies (Other)
0.000 0.284 0.716
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.284 0.716
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.284 0.716
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.284 0.715
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.285 0.715
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.285 0.714
H35.2 Other proliferative retinopathy
0.000 0.286 0.714
E11.0 With coma
0.000 0.286 0.714
G37.5 Concentric sclerosis [Balo]
0.713 0.287 0.000
G37.4 Subacute necrotising myelitis
0.713 0.287 0.000
G37.2 Central pontine myelinolysis
0.713 0.287 0.000
G37.1 Central demyelination of corpus callosum
0.713 0.287 0.000
G37.0 Diffuse sclerosis
0.713 0.287 0.000
M49 Spondylopathies in diseases classified elsewhere
0.000 0.288 0.712
M31.7 Microscopic polyangiitis
0.000 0.288 0.712
L44 Other papulosquamous disorders
0.000 0.289 0.711
L41 Parapsoriasis
0.000 0.289 0.711
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.289 0.711
H30 Chorioretinal inflammation
0.000 0.289 0.711
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.290 0.710
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.290 0.710
M35.5 Multifocal fibrosclerosis
0.000 0.290 0.710
H54.1 Blindness, one eye, low vision, other eye
0.000 0.291 0.709
E78.6 Lipoprotein deficiency
0.000 0.291 0.709
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.292 0.708
H34.1 Central retinal artery occlusion
0.000 0.292 0.708
L85 Other epidermal thickening
0.000 0.293 0.707
L40.4 Guttate psoriasis
0.000 0.295 0.705
L84 Corns and callosities
0.000 0.295 0.705
M91-M94 Chondropathies
0.000 0.295 0.705
D50.9 Iron deficiency anaemia, unspecified
0.000 0.295 0.705
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.297 0.703
J43.1 Panlobular emphysema
0.000 0.299 0.701
J43.0 MacLeod's syndrome
0.000 0.299 0.701
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.299 0.701
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.299 0.701
M06.38 Rheumatoid nodule (Other)
0.000 0.299 0.701
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.299 0.701
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.299 0.701
M06.33 Rheumatoid nodule (Forearm)
0.000 0.299 0.701
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.299 0.701
L92.0 Granuloma annulare
0.000 0.299 0.701
M07.6 Other enteropathic arthropathies
0.000 0.300 0.700
E07 Other disorders of thyroid
0.000 0.301 0.699
E06.5 Other chronic thyroiditis
0.000 0.302 0.698
H34.2 Other retinal artery occlusions
0.000 0.303 0.697
M24.1 Other articular cartilage disorders
0.000 0.304 0.696
H54.9 Unspecified visual impairment (binocular)
0.000 0.304 0.696
M05.2 Rheumatoid vasculitis
0.000 0.305 0.695
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.000 0.306 0.694
M12.3 Palindromic rheumatism
0.000 0.307 0.693
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.308 0.692
J39.8 Other specified diseases of upper respiratory tract
0.000 0.308 0.692
M06.1 Adult-onset Still's disease
0.000 0.309 0.691
M15-M19 Arthrosis
0.000 0.310 0.690
M82 Osteoporosis in diseases classified elsewhere
0.000 0.312 0.688
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.000 0.312 0.688
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.314 0.686
M31.8 Other specified necrotising vasculopathies
0.000 0.315 0.685
M00-M03 Infectious arthropathies
0.000 0.318 0.682
M18 Arthrosis of first carpometacarpal joint
0.000 0.319 0.681
E88.2 Lipomatosis, not elsewhere classified
0.000 0.319 0.681
E11.5 With peripheral circulatory complications
0.000 0.320 0.680
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.322 0.678
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.322 0.678
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.322 0.678
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.322 0.678
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.322 0.678
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.322 0.678
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.322 0.678
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.322 0.678
H33.1 Retinoschisis and retinal cysts
0.000 0.323 0.677
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.326 0.674
E70 Disorders of aromatic amino-acid metabolism
0.000 0.327 0.672
M18.1 Other primary arthrosis of first carpometacarpal joint
0.000 0.329 0.671
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.329 0.671
E14.5 With peripheral circulatory complications
0.000 0.329 0.671
L85.8 Other specified epidermal thickening
0.000 0.329 0.671
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.329 0.670
E03.1 Congenital hypothyroidism without goitre
0.000 0.330 0.670
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.333 0.667
M24.16 Other articular cartilage disorders (Lower leg)
0.000 0.333 0.667
E83.3 Disorders of phosphorus metabolism
0.661 0.334 0.006
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.335 0.664
M31.2 Lethal midline granuloma
0.000 0.335 0.664
M31.3 Wegener's granulomatosis
0.000 0.336 0.664
M34.1 CR(E)ST syndrome
0.000 0.336 0.663
K50-K52 Noninfective enteritis and colitis
0.005 0.337 0.658
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.337 0.663
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.338 0.662
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.339 0.661
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.339 0.661
L87 Transepidermal elimination disorders
0.000 0.339 0.661
L86 Keratoderma in diseases classified elsewhere
0.000 0.339 0.661
M32 Systemic lupus erythematosus
0.000 0.340 0.660
H35.6 Retinal haemorrhage
0.000 0.340 0.660
E74 Other disorders of carbohydrate metabolism
0.000 0.340 0.659
M31.1 Thrombotic microangiopathy
0.000 0.341 0.659
L12 Pemphigoid
0.000 0.342 0.658
J45.1 Nonallergic asthma
0.000 0.343 0.657
J96 Respiratory failure, not elsewhere classified
0.000 0.345 0.655
H33.2 Serous retinal detachment
0.000 0.346 0.654
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.000 0.346 0.654
E56 Other vitamin deficiencies
0.000 0.347 0.653
M06.8 Other specified rheumatoid arthritis
0.000 0.347 0.653
H10-H13 Disorders of conjunctiva
0.000 0.347 0.653
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.348 0.652
K71 Toxic liver disease
0.000 0.348 0.652
E83.5 Disorders of calcium metabolism
0.651 0.349 0.001
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.349 0.651
M67 Other disorders of synovium and tendon
0.000 0.350 0.650
H54.5 Low vision, one eye
0.000 0.350 0.650
L13 Other bullous disorders
0.000 0.350 0.650
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.350 0.650
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.350 0.650
K90.3 Pancreatic steatorrhoea
0.000 0.351 0.648
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.351 0.648
K90.1 Tropical sprue
0.000 0.351 0.648
E06.9 Thyroiditis, unspecified
0.000 0.352 0.648
K82 Other diseases of gallbladder
0.000 0.352 0.648
K73.9 Chronic hepatitis, unspecified
0.000 0.353 0.647
E14.4 With neurological complications
0.000 0.353 0.647
E11.4 With neurological complications
0.000 0.354 0.646
M24.7 Protrusio acetabuli
0.000 0.357 0.643
E51 Thiamine deficiency
0.000 0.358 0.642
E06.4 Drug-induced thyroiditis
0.000 0.360 0.640
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.360 0.640
E06.1 Subacute thyroiditis
0.000 0.360 0.640
E06.0 Acute thyroiditis
0.000 0.360 0.640
H20 Iridocyclitis
0.000 0.360 0.640
E77 Disorders of glycoprotein metabolism
0.000 0.360 0.640
E76 Disorders of glycosaminoglycan metabolism
0.000 0.360 0.640
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.360 0.640
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.360 0.640
H54.3 Unqualified visual loss, both eyes
0.000 0.360 0.640
L92.2 Granuloma faciale [eosinophilic granuloma of skin]
0.000 0.362 0.638
M06.0 Seronegative rheumatoid arthritis
0.000 0.363 0.637
K82.8 Other specified diseases of gallbladder
0.000 0.363 0.637
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.364 0.636
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.365 0.635
J95.5 Postprocedural subglottic stenosis
0.000 0.365 0.635
J95.4 Mendelson's syndrome
0.000 0.365 0.635
J95.3 Chronic pulmonary insufficiency following surgery
0.000 0.365 0.635
J95.2 Acute pulmonary insufficiency following nonthoracic surgery
0.000 0.365 0.635
J95.1 Acute pulmonary insufficiency following thoracic surgery
0.000 0.365 0.635
E88.8 Other specified metabolic disorders
0.000 0.366 0.634
H54.6 Unqualified visual loss, one eye
0.000 0.366 0.633
K50 Crohn's disease [regional enteritis]
0.000 0.367 0.633
K81 Cholecystitis
0.000 0.369 0.631
D62 Acute posthaemorrhagic anaemia
0.000 0.371 0.629
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.371 0.629
L94.2 Calcinosis cutis
0.000 0.371 0.629
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.371 0.629
E63 Other nutritional deficiencies
0.000 0.371 0.629
E50 Vitamin A deficiency
0.000 0.371 0.629
E60 Dietary zinc deficiency
0.000 0.371 0.629
E59 Dietary selenium deficiency
0.000 0.371 0.629
E52 Niacin deficiency [pellagra]
0.000 0.371 0.629
E83.9 Disorder of mineral metabolism, unspecified
0.613 0.372 0.015
H34.0 Transient retinal artery occlusion
0.000 0.372 0.628
M35.8 Other specified systemic involvement of connective tissue
0.000 0.373 0.627
H20.0 Acute and subacute iridocyclitis
0.000 0.374 0.626
M24.11 Other articular cartilage disorders (Shoulder region)
0.000 0.378 0.622
M12.2 Villonodular synovitis (pigmented)
0.000 0.379 0.621
M34.8 Other forms of systemic sclerosis
0.000 0.379 0.621
H43 Disorders of vitreous body
0.000 0.380 0.620
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.383 0.617
M14 Arthropathies in other diseases classified elsewhere
0.000 0.383 0.617
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.383 0.617
J39.0 Retropharyngeal and parapharyngeal abscess
0.000 0.384 0.616
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.386 0.614
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.387 0.613
J41 Simple and mucopurulent chronic bronchitis
0.000 0.388 0.611
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)
0.000 0.389 0.611
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.000 0.390 0.610
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.000 0.391 0.609
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.392 0.608
E54 Ascorbic acid deficiency
0.000 0.392 0.608
E72 Other disorders of amino-acid metabolism
0.000 0.392 0.607
M94 Other disorders of cartilage
0.000 0.393 0.607
M60-M63 Disorders of muscles
0.000 0.394 0.606
M82.1 Osteoporosis in endocrine disorders
0.000 0.394 0.606
E78.8 Other disorders of lipoprotein metabolism
0.000 0.394 0.606
G36.0 Neuromyelitis optica [Devic]
0.605 0.395 0.000
M86 Osteomyelitis
0.000 0.396 0.604
K81.1 Chronic cholecystitis
0.000 0.396 0.604
E53.1 Pyridoxine deficiency
0.000 0.397 0.603
E53.0 Riboflavin deficiency
0.000 0.397 0.603
H35.1 Retinopathy of prematurity
0.000 0.398 0.601
K77 Liver disorders in diseases classified elsewhere
0.000 0.399 0.601
K75.2 Nonspecific reactive hepatitis
0.000 0.399 0.601
K75.1 Phlebitis of portal vein
0.000 0.399 0.601
E78.3 Hyperchylomicronaemia
0.000 0.402 0.598
M12.5 Traumatic arthropathy
0.000 0.402 0.598
M12.39 Palindromic rheumatism (Site unspecified)
0.000 0.402 0.598
L92.1 Necrobiosis lipoidica, not elsewhere classified
0.000 0.402 0.598
J37 Chronic laryngitis and laryngotracheitis
0.000 0.403 0.597
J42 Unspecified chronic bronchitis
0.000 0.404 0.596
M12.8 Other specific arthropathies, not elsewhere classified
0.000 0.404 0.596
M12.4 Intermittent hydrarthrosis
0.000 0.404 0.595
M12.1 Kaschin-Beck disease
0.000 0.404 0.595
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.000 0.404 0.595
J95.9 Postprocedural respiratory disorder, unspecified
0.000 0.407 0.593
L90.8 Other atrophic disorders of skin
0.000 0.407 0.592
M31.9 Necrotising vasculopathy, unspecified
0.000 0.408 0.592
D51 Vitamin B12 deficiency anaemia
0.000 0.408 0.592
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.409 0.591
E79 Disorders of purine and pyrimidine metabolism
0.000 0.410 0.590
K50.8 Other Crohn's disease
0.000 0.411 0.589
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.412 0.588
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.412 0.588
D64.4 Congenital dyserythropoietic anaemia
0.000 0.413 0.587
D64.3 Other sideroblastic anaemias
0.000 0.413 0.587
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.413 0.587
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.413 0.587
D64.0 Hereditary sideroblastic anaemia
0.000 0.413 0.587
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.000 0.413 0.587
M30.0 Polyarteritis nodosa
0.000 0.413 0.587
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.414 0.585
H35.7 Separation of retinal layers
0.000 0.415 0.585
J22 Unspecified acute lower respiratory infection
0.000 0.415 0.585
M83 Adult osteomalacia
0.000 0.416 0.584
E73 Lactose intolerance
0.000 0.418 0.582
M88 Paget's disease of bone [osteitis deformans]
0.000 0.420 0.580
L90.9 Atrophic disorder of skin, unspecified
0.000 0.420 0.579
L90.6 Striae atrophicae
0.000 0.420 0.579
L90.4 Acrodermatitis chronica atrophicans
0.000 0.420 0.579
L90.3 Atrophoderma of Pasini and Pierini
0.000 0.420 0.579
L90.2 Anetoderma of Jadassohn-Pellizzari
0.000 0.420 0.579
L90.1 Anetoderma of Schweninger-Buzzi
0.000 0.420 0.579
J99.0 Rheumatoid lung disease
0.000 0.421 0.579
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.422 0.578
K50.1 Crohn's disease of large intestine
0.000 0.422 0.578
M34.0 Progressive systemic sclerosis
0.000 0.423 0.577
K81.9 Cholecystitis, unspecified
0.000 0.424 0.576
J45.8 Mixed asthma
0.000 0.424 0.576
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.425 0.575
H34.8 Other retinal vascular occlusions
0.000 0.425 0.575
M66 Spontaneous rupture of synovium and tendon
0.000 0.427 0.573
H31 Other disorders of choroid
0.000 0.427 0.573
H43.1 Vitreous haemorrhage
0.000 0.430 0.570
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.431 0.569
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.000 0.431 0.569
M15 Polyarthrosis
0.000 0.433 0.567
L14 Bullous disorders in diseases classified elsewhere
0.000 0.433 0.567
D53 Other nutritional anaemias
0.000 0.436 0.564
M24.0 Loose body in joint
0.000 0.436 0.564
M24.75 Protrusio acetabuli-Pelvic/thigh
0.000 0.436 0.564
E78.1 Pure hyperglyceridaemia
0.000 0.437 0.563
E28 Ovarian dysfunction
0.000 0.437 0.563
L12.1 Cicatricial pemphigoid
0.000 0.440 0.560
L88 Pyoderma gangrenosum
0.000 0.440 0.559
E11.6 With other specified complications
0.000 0.441 0.559
J39.3 Upper respiratory tract hypersensitivity reaction, site unspecified
0.000 0.441 0.559
M80.4 Drug-induced osteoporosis with pathological fracture
0.000 0.442 0.558
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture
0.000 0.442 0.558
M80.2 Osteoporosis of disuse with pathological fracture
0.000 0.442 0.558
M24.6 Ankylosis of joint
0.000 0.444 0.556
M34.9 Systemic sclerosis, unspecified
0.000 0.446 0.554
E61 Deficiency of other nutrient elements
0.000 0.447 0.553
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)
0.000 0.448 0.552
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)
0.000 0.448 0.552
M80.94 Unspecified osteoporosis with pathological fracture (Hand)
0.000 0.448 0.552

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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