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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2395153
log Bayes Factor = 236.625
Chromosome 6   position 32,345,595  (GRCh37) Explore rs2395153 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
1.000 0.000 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
1.000 0.000 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
1.000 0.000 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
1.000 0.000 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
1.000 0.000 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
J45.9 Asthma, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
G35 Multiple sclerosis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
M05-M14 Inflammatory polyarthropathies
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
J33.9 Nasal polyp, unspecified
1.000 0.000 0.000
M05 Seropositive rheumatoid arthritis
1.000 0.000 0.000
M35.3 Polymyalgia rheumatica
1.000 0.000 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
J33 Nasal polyp
1.000 0.000 0.000
D86 Sarcoidosis
0.000 0.000 1.000
M06.3 Rheumatoid nodule
1.000 0.000 0.000
M45 Ankylosing spondylitis
1.000 0.000 0.000
J30-J39 Other diseases of upper respiratory tract
1.000 0.000 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
1.000 0.000 0.000
M45-M49 Spondylopathies
1.000 0.000 0.000
J45 Asthma
1.000 0.000 0.000
J40-J47 Chronic lower respiratory diseases
1.000 0.000 0.000
M06.0 Seronegative rheumatoid arthritis
1.000 0.000 0.000
M35 Other systemic involvement of connective tissue
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.001 0.999
D80-D89 Certain disorders involving the immune mechanism
0.000 0.001 0.999
R31 Unspecified haematuria
0.999 0.001 0.000
D86.0 Sarcoidosis of lung
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.999 0.001 0.000
J32 Chronic sinusitis
0.999 0.001 0.000
M20 Acquired deformities of fingers and toes
0.999 0.001 0.000
M06.34 Rheumatoid nodule (Hand)
0.999 0.001 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.998 0.002 0.000
J32.9 Chronic sinusitis, unspecified
0.997 0.003 0.000
E10-E14 Diabetes mellitus
0.997 0.003 0.000
M31 Other necrotising vasculopathies
0.995 0.005 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.005 0.995
E10.4 With neurological complications
0.995 0.005 0.000
Chapter X Diseases of the respiratory system
0.992 0.008 0.000
M31.6 Other giant cell arteritis
0.991 0.009 0.000
J47 Bronchiectasis
0.990 0.010 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.989 0.011 0.000
E10.1 With ketoacidosis
0.989 0.011 0.000
M20.4 Other hammer toe(s) (acquired)
0.987 0.013 0.000
D86.9 Sarcoidosis, unspecified
0.000 0.015 0.985
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.982 0.018 0.000
D68 Other coagulation defects
0.000 0.018 0.982
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.982 0.018 0.000
M06.4 Inflammatory polyarthropathy
0.981 0.019 0.000
M65-M68 Disorders of synovium and tendon
0.980 0.020 0.000
D50-D53 Nutritional anaemias
0.000 0.020 0.980
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.975 0.025 0.000
E14 Unspecified diabetes mellitus
0.973 0.027 0.000
J46 Status asthmaticus
0.970 0.030 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.031 0.969
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.968 0.032 0.000
M65 Synovitis and tenosynovitis
0.967 0.033 0.000
J38.3 Other diseases of vocal cords
0.965 0.035 0.000
M30 Polyarteritis nodosa and related conditions
0.963 0.037 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.962 0.038 0.000
E10.5 With peripheral circulatory complications
0.958 0.042 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.032 0.045 0.924
E14.3 With ophthalmic complications
0.953 0.047 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.949 0.051 0.000
D51 Vitamin B12 deficiency anaemia
0.000 0.053 0.947
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.943 0.057 0.000
D86.3 Sarcoidosis of skin
0.000 0.058 0.942
D55-D59 Haemolytic anaemias
0.000 0.058 0.942
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.941 0.059 0.000
D52 Folate deficiency anaemia
0.000 0.063 0.937
M06.32 Rheumatoid nodule (Upper arm)
0.936 0.064 0.000
E10.6 With other specified complications
0.932 0.068 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.931 0.069 0.000
M20.1 Hallux valgus (acquired)
0.930 0.070 0.000
E11 Non-insulin-dependent diabetes mellitus
0.923 0.077 0.000
E00-E07 Disorders of thyroid gland
0.719 0.078 0.203
E05.9 Thyrotoxicosis, unspecified
0.000 0.079 0.921
M20.6 Acquired deformity of toe(s), unspecified
0.919 0.081 0.000
D68.8 Other specified coagulation defects
0.000 0.082 0.918
J33.0 Polyp of nasal cavity
0.917 0.083 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.719 0.084 0.197
J42 Unspecified chronic bronchitis
0.916 0.084 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.912 0.087 0.000
D59 Acquired haemolytic anaemia
0.000 0.090 0.910
M34 Systemic sclerosis
0.907 0.093 0.000
D52.9 Folate deficiency anaemia, unspecified
0.000 0.093 0.907
M20.5 Other deformities of toe(s) (acquired)
0.905 0.095 0.000
M46 Other inflammatory spondylopathies
0.903 0.097 0.000
D60-D64 Aplastic and other anaemias
0.000 0.100 0.900
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)
0.899 0.101 0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.897 0.103 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.894 0.106 0.000
M14 Arthropathies in other diseases classified elsewhere
0.893 0.107 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.889 0.111 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.889 0.111 0.000
J32.4 Chronic pansinusitis
0.889 0.111 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.113 0.887
D61 Other aplastic anaemias
0.000 0.114 0.886
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.886 0.114 0.000
M65.4 Radial styloid tenosynovitis [de Quervain]
0.884 0.116 0.000
E10.0 With coma
0.882 0.118 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.120 0.880
J33.8 Other polyp of sinus
0.879 0.121 0.000
D61.9 Aplastic anaemia, unspecified
0.000 0.124 0.876
E11.9 Without complications
0.873 0.127 0.000
J35 Chronic diseases of tonsils and adenoids
0.871 0.129 0.000
M05.8 Other seropositive rheumatoid arthritis
0.869 0.131 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.134 0.866
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.135 0.865
D69 Purpura and other haemorrhagic conditions
0.000 0.135 0.865
D59.1 Other autoimmune haemolytic anaemias
0.000 0.136 0.864
E14.6 With other specified complications
0.860 0.140 0.000
J38.4 Oedema of larynx
0.855 0.145 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.852 0.148 0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.844 0.156 0.000
D86.1 Sarcoidosis of lymph nodes
0.000 0.157 0.843
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.843 0.157 0.000
M06.33 Rheumatoid nodule (Forearm)
0.839 0.161 0.000
M46.1 Sacro-iliitis, not elsewhere classified
0.833 0.167 0.000
J09-J18 Influenza and pneumonia
0.833 0.167 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.832 0.168 0.000
E03 Other hypothyroidism
0.764 0.173 0.063
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.826 0.174 0.000
M20.0 Deformity of finger(s)
0.825 0.175 0.000
J38.7 Other diseases of larynx
0.823 0.177 0.000
M31.7 Microscopic polyangiitis
0.822 0.178 0.000
J32.1 Chronic frontal sinusitis
0.821 0.179 0.000
M05.1 Rheumatoid lung disease
0.821 0.179 0.000
M08 Juvenile arthritis
0.820 0.180 0.000
D68.6 Other Thrombophilia
0.000 0.181 0.819
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.819 0.181 0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.817 0.183 0.000
M14.6 Neuropathic arthropathy
0.816 0.184 0.000
D68.0 Von Willebrand's disease
0.000 0.184 0.816
M30.0 Polyarteritis nodosa
0.815 0.185 0.000
M66 Spontaneous rupture of synovium and tendon
0.815 0.185 0.000
D68.2 Hereditary deficiency of other clotting factors
0.000 0.187 0.813
J45.1 Nonallergic asthma
0.813 0.187 0.000
M12 Other specific arthropathies
0.812 0.188 0.000
M65.1 Other infective (teno)synovitis
0.811 0.189 0.000
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.811 0.189 0.000
E03.9 Hypothyroidism, unspecified
0.810 0.190 0.000
D68.5 Primary Thrombophilia
0.000 0.193 0.807
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.806 0.194 0.000
K90 Intestinal malabsorption
0.000 0.194 0.806
D86.8 Sarcoidosis of other and combined sites
0.000 0.195 0.805
J38.5 Laryngeal spasm
0.804 0.196 0.000
E10.2 With renal complications
0.803 0.197 0.000
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.198 0.802
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.799 0.200 0.000
E14.0 With coma
0.795 0.205 0.000
E11.0 With coma
0.790 0.210 0.000
E13 Other specified diabetes mellitus
0.787 0.213 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.787 0.213 0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.786 0.214 0.000
J32.2 Chronic ethmoidal sinusitis
0.785 0.215 0.000
J95-J99 Other diseases of the respiratory system
0.785 0.215 0.000
E11.4 With neurological complications
0.784 0.216 0.000
M06.46 Inflammatory polyarthropathy (Lower leg)
0.783 0.217 0.000
M34.1 CR(E)ST syndrome
0.776 0.224 0.000
M35.1 Other overlap syndromes
0.771 0.229 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.771 0.229 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.770 0.230 0.000
J33.1 Polypoid sinus degeneration
0.769 0.231 0.000
M30.8 Other conditions related to polyarteritis nodosa
0.765 0.235 0.000
M00-M03 Infectious arthropathies
0.763 0.237 0.000
M46.18 Sacroiliitis, not elsewhere classified-Sacral/sacrococ
0.762 0.238 0.000
M05.2 Rheumatoid vasculitis
0.759 0.241 0.000
J35.1 Hypertrophy of tonsils
0.759 0.241 0.000
D61.0 Constitutional aplastic anaemia
0.000 0.242 0.758
D69.4 Other primary thrombocytopenia
0.000 0.242 0.758
J45.8 Mixed asthma
0.757 0.243 0.000
E10.8 With unspecified complications
0.756 0.244 0.000
J32.0 Chronic maxillary sinusitis
0.754 0.246 0.000
J35.8 Other chronic diseases of tonsils and adenoids
0.754 0.246 0.000
E11.6 With other specified complications
0.748 0.251 0.000
D69.6 Thrombocytopenia, unspecified
0.000 0.254 0.746
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.254 0.746
M06.8 Other specified rheumatoid arthritis
0.745 0.255 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.255 0.745
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.742 0.258 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.741 0.259 0.000
M34.9 Systemic sclerosis, unspecified
0.741 0.259 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.259 0.741
J99 Respiratory disorders in diseases classified elsewhere
0.739 0.261 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.739 0.261 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.737 0.263 0.000
D68.4 Acquired coagulation factor deficiency
0.000 0.264 0.736
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.266 0.734
D68.1 Hereditary factor XI deficiency
0.000 0.268 0.732
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.731 0.269 0.000
J35.2 Hypertrophy of adenoids
0.731 0.269 0.000
M65.8 Other synovitis and tenosynovitis
0.729 0.271 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.001 0.272 0.727
J38.6 Stenosis of larynx
0.725 0.274 0.000
E14.5 With peripheral circulatory complications
0.725 0.275 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.724 0.276 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.724 0.276 0.000
E14.4 With neurological complications
0.724 0.276 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.277 0.723
J12 Viral pneumonia, not elsewhere classified
0.722 0.278 0.000
D66 Hereditary factor VIII deficiency
0.000 0.279 0.721
M35.8 Other specified systemic involvement of connective tissue
0.720 0.280 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.282 0.718
M31.8 Other specified necrotising vasculopathies
0.717 0.282 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.717 0.283 0.000
M06.2 Rheumatoid bursitis
0.717 0.283 0.000
M06.1 Adult-onset Still's disease
0.717 0.283 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.717 0.283 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.717 0.283 0.000
M05.0 Felty's syndrome
0.717 0.283 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.717 0.283 0.000
M06.38 Rheumatoid nodule (Other)
0.717 0.283 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.717 0.283 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.717 0.283 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.717 0.283 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.717 0.283 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.717 0.283 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.717 0.283 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.717 0.283 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.717 0.283 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.717 0.283 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.717 0.283 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.717 0.283 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.717 0.283 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.717 0.283 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.717 0.283 0.000
M35.5 Multifocal fibrosclerosis
0.717 0.283 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.717 0.283 0.000
D81 Combined immunodeficiencies
0.000 0.283 0.716
E14.2 Withrenal complications
0.716 0.284 0.000
M31.3 Wegener's granulomatosis
0.716 0.284 0.000
E12 Malnutrition-related diabetes mellitus
0.715 0.285 0.000
M31.2 Lethal midline granuloma
0.713 0.287 0.000
M31.9 Necrotising vasculopathy, unspecified
0.712 0.287 0.000
M13 Other arthritis
0.707 0.293 0.000
M46.4 Discitis, unspecified
0.706 0.293 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.706 0.294 0.000
M34.8 Other forms of systemic sclerosis
0.706 0.294 0.000
M06.48 Inflammatory polyarthropathy (Other)
0.703 0.296 0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.703 0.296 0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.703 0.296 0.000
M06.44 Inflammatory polyarthropathy (Hand)
0.703 0.296 0.000
M06.43 Inflammatory polyarthropathy (Forearm)
0.703 0.296 0.000
M06.42 Inflammatory polyarthropathy (Upper arm)
0.703 0.296 0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.703 0.296 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.703 0.297 0.000
D82 Immunodeficiency associated with other major defects
0.000 0.298 0.702
M49 Spondylopathies in diseases classified elsewhere
0.701 0.299 0.000
M65.14 Other infective (teno)synovitis (Hand)
0.700 0.300 0.000
E14.7 With multiple complications
0.698 0.302 0.000
M14.2 Diabetic arthropathy
0.696 0.304 0.000
J41 Simple and mucopurulent chronic bronchitis
0.696 0.304 0.000
E10.7 With multiple complications
0.694 0.306 0.000
J99.0 Rheumatoid lung disease
0.694 0.306 0.000
D56 Thalassaemia
0.000 0.306 0.694
M65.0 Abscess of tendon sheath
0.693 0.307 0.000
M65.2 Calcific tendinitis
0.693 0.307 0.000
J11 Influenza, virus not identified
0.692 0.308 0.000
M05.19 Rheumatoid lung disease (Site unspecified)
0.692 0.308 0.000
M66.5 Spontaneous rupture of unspecified tendon
0.691 0.309 0.000
M08.0 Juvenile rheumatoid arthritis
0.691 0.309 0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.691 0.309 0.000
M30.2 Juvenile polyarteritis
0.691 0.309 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.689 0.311 0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.687 0.313 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.687 0.313 0.000
E05.5 Thyroid crisis or storm
0.023 0.315 0.662
E05.4 Thyrotoxicosis factitia
0.023 0.315 0.662
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.023 0.315 0.662
E07 Other disorders of thyroid
0.529 0.315 0.156
E27.1 Primary adrenocortical insufficiency
0.000 0.315 0.685
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.684 0.316 0.000
E11.7 With multiple complications
0.682 0.318 0.000
G37 Other demyelinating diseases of central nervous system
0.000 0.320 0.680
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.680 0.320 0.000
J32.3 Chronic sphenoidal sinusitis
0.679 0.321 0.000
M35.2 Behcet's disease
0.679 0.321 0.000
D51.2 Transcobalamin II deficiency
0.000 0.321 0.679
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.321 0.679
J37 Chronic laryngitis and laryngotracheitis
0.678 0.322 0.000
E11.5 With peripheral circulatory complications
0.678 0.322 0.000
D55 Anaemia due to enzyme disorders
0.000 0.325 0.675
D57 Sickle-cell disorders
0.000 0.327 0.673
D52.8 Other folate deficiency anaemias
0.000 0.328 0.672
D52.1 Drug-induced folate deficiency anaemia
0.000 0.328 0.672
D52.0 Dietary folate deficiency anaemia
0.000 0.328 0.672
M12.3 Palindromic rheumatism
0.670 0.330 0.000
M46.2 Osteomyelitis of vertebra
0.669 0.331 0.000
M65.98 Synovitis and tenosynovitis, unspecified (Other)
0.668 0.332 0.000
E27 Other disorders of adrenal gland
0.000 0.333 0.667
J38.0 Paralysis of vocal cords and larynx
0.666 0.334 0.000
M46.19 Sacroiliitis, not elsewhere classified-Site unspe
0.666 0.334 0.000
M46.3 Infection of intervertebral disk (pyogenic)
0.664 0.336 0.000
M66.2 Spontaneous rupture of extensor tendons
0.662 0.338 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.565 0.339 0.096
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.516 0.339 0.145
E00 Congenital iodine-deficiency syndrome
0.516 0.339 0.145
J17 Pneumonia in diseases classified elsewhere
0.660 0.340 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.342 0.658
E14.8 With unspecified complications
0.654 0.346 0.000
E06 Thyroiditis
0.573 0.346 0.080
D59.8 Other acquired haemolytic anaemias
0.000 0.347 0.653
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.347 0.653
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.347 0.653
D59.3 Haemolytic-uraemic syndrome
0.000 0.347 0.653
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.347 0.653
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.347 0.653
E03.8 Other specified hypothyroidism
0.626 0.347 0.027
D83 Common variable immunodeficiency
0.000 0.348 0.652
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.348 0.652
M34.2 Systemic sclerosis induced by drugs and chemicals
0.650 0.349 0.000
M34.0 Progressive systemic sclerosis
0.650 0.349 0.000
M46.8 Other specified inflammatory spondylopathies
0.648 0.352 0.000
M46.5 Other infective spondylopathies
0.648 0.352 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.354 0.646
M31.1 Thrombotic microangiopathy
0.645 0.354 0.000
M46.0 Spinal enthesopathy
0.645 0.355 0.000
M66.3 Spontaneous rupture of flexor tendons
0.641 0.358 0.000
E11.8 With unspecified complications
0.640 0.360 0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.640 0.360 0.000
M14.4 Arthropathy in amyloidosis
0.640 0.360 0.000
M14.3 Lipoid dermatoarthritis
0.640 0.360 0.000
M14.1 Crystal arthropathy in other metabolic disorders
0.640 0.360 0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.640 0.360 0.000
K90.8 Other intestinal malabsorption
0.000 0.360 0.640
J99.8 Respiratory disorders in other diseases classified elsewhere
0.639 0.361 0.000
M65.86 Other synovitis and tenosynovitis (Lower leg)
0.639 0.361 0.000
M21 Other acquired deformities of limbs
0.636 0.364 0.000
D61.8 Other specified aplastic anaemias
0.000 0.364 0.635
D61.3 Idiopathic aplastic anaemia
0.000 0.364 0.635
D61.2 Aplastic anaemia due to other external agents
0.000 0.364 0.635
E03.1 Congenital hypothyroidism without goitre
0.597 0.365 0.039
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec
0.634 0.366 0.000
M65.48 Radial styloid tenosynovitis [de Quervain]-Other
0.634 0.366 0.000
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot
0.634 0.366 0.000
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg
0.634 0.366 0.000
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh
0.634 0.366 0.000
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm
0.634 0.366 0.000
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region
0.634 0.366 0.000
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)
0.634 0.366 0.000
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)
0.629 0.371 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.372 0.628
J35.3 Hypertrophy of tonsils with hypertrophy of adenoids
0.625 0.375 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.479 0.376 0.146
E20-E35 Disorders of other endocrine glands
0.005 0.376 0.620
M60-M63 Disorders of muscles
0.623 0.377 0.000
M05.88 Other seropositive rheumatoid arthritis (Other)
0.623 0.377 0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.623 0.377 0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.623 0.377 0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.623 0.377 0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.623 0.377 0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.623 0.377 0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.623 0.377 0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.623 0.377 0.000
M00 Pyogenic arthritis
0.622 0.378 0.000
D69.1 Qualitative platelet defects
0.000 0.378 0.622
D89.3 Immune reconstitution syndrome
0.000 0.379 0.620
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.380 0.620
D69.8 Other specified haemorrhagic conditions
0.000 0.380 0.620
J85 Abscess of lung and mediastinum
0.616 0.384 0.000
E13.3 With ophthalmic complications
0.613 0.387 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.613 0.387 0.000
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.388 0.612
D69.0 Allergic purpura
0.000 0.388 0.612
J12.9 Viral pneumonia, unspecified
0.606 0.394 0.000
M08.00 Juvenile rheumatoid arthritis (Multiple sites)
0.598 0.402 0.000
M46.17 Sacroiliitis, not elsewhere classified-Lumbosacral
0.597 0.403 0.000
M46.16 Sacroiliitis, not elsewhere classified-Lumbar
0.597 0.403 0.000
M46.15 Sacroiliitis, not elsewhere classified-Thoracolumbar
0.597 0.403 0.000
M46.14 Sacroiliitis, not elsewhere classified-Thoracic
0.597 0.403 0.000
M46.13 Sacroiliitis, not elsewhere classified-Cervicothoracic
0.597 0.403 0.000
M46.12 Sacroiliitis, not elsewhere classified-Cervical
0.597 0.403 0.000
M46.11 Sacroiliitis, not elsewhere classified-Occipit-atl-axl
0.597 0.403 0.000
M46.10 Sacroiliitis, not elsewhere classified-Mult site
0.597 0.403 0.000
J09 Influenza due to certain identified influenza virus
0.597 0.403 0.000
M13.8 Other specified arthritis
0.597 0.403 0.000
D84 Other immunodeficiencies
0.000 0.404 0.596
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.596 0.404 0.000
E13.9 Without complications
0.596 0.404 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.552 0.405 0.043
E03.5 Myxoedema coma
0.548 0.407 0.045
E03.4 Atrophy of thyroid (acquired)
0.548 0.407 0.045
E03.3 Postinfectious hypothyroidism
0.548 0.407 0.045
M12.2 Villonodular synovitis (pigmented)
0.593 0.407 0.000
M66.54 Spontaneous rupture of unspecified tendon (Hand)
0.593 0.407 0.000
D67 Hereditary factor IX deficiency
0.000 0.408 0.591
E14.1 With ketoacidosis
0.590 0.410 0.000
E27.2 Addisonian crisis
0.000 0.410 0.590
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.025 0.411 0.564
M05.18 Rheumatoid lung disease (Other)
0.588 0.411 0.000
M05.17 Rheumatoid lung disease (Ankle and foot)
0.588 0.411 0.000
M05.16 Rheumatoid lung disease (Lower leg)
0.588 0.411 0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.588 0.411 0.000
M05.14 Rheumatoid lung disease (Hand)
0.588 0.411 0.000
M05.13 Rheumatoid lung disease (Forearm)
0.588 0.411 0.000
M05.12 Rheumatoid lung disease (Upper arm)
0.588 0.411 0.000
M05.11 Rheumatoid lung disease (Shoulder region)
0.588 0.411 0.000
M05.10 Rheumatoid lung disease (Multiple sites)
0.588 0.411 0.000
M08.9 Juvenile arthritis, unspecified
0.588 0.412 0.000
M08.8 Other juvenile arthritis
0.588 0.412 0.000
M08.4 Pauciarticular juvenile arthritis
0.588 0.412 0.000
M08.3 Juvenile polyarthritis (seronegative)
0.588 0.412 0.000
M08.2 Juvenile arthritis with systemic onset
0.588 0.412 0.000
M08.1 Juvenile ankylosing spondylitis
0.588 0.412 0.000
M05.20 Rheumatoid vasculitis (Multiple sites)
0.586 0.414 0.000
J16.8 Pneumonia due to other specified infectious organisms
0.586 0.414 0.000
E22 Hyperfunction of pituitary gland
0.001 0.415 0.585
D89.1 Cryoglobulinaemia
0.000 0.415 0.585
M66.24 Spontaneous rupture of extensor tendons (Hand)
0.584 0.415 0.000
M66.1 Rupture of synovium
0.584 0.416 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.416 0.584
M12.8 Other specific arthropathies, not elsewhere classified
0.583 0.416 0.000
M12.5 Traumatic arthropathy
0.582 0.418 0.000
M12.4 Intermittent hydrarthrosis
0.582 0.418 0.000
M12.1 Kaschin-Beck disease
0.582 0.418 0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.582 0.418 0.000
M65.19 Other infective (teno)synovitis (Site unspecified)
0.582 0.418 0.000
M65.18 Other infective (teno)synovitis (Other)
0.582 0.418 0.000
M65.17 Other infective (teno)synovitis (Ankle and foot)
0.582 0.418 0.000
M65.16 Other infective (teno)synovitis (Lower leg)
0.582 0.418 0.000
M65.15 Other infective (teno)synovitis (Pelvic region and thigh)
0.582 0.418 0.000
M65.13 Other infective (teno)synovitis (Forearm)
0.582 0.418 0.000
M65.12 Other infective (teno)synovitis (Upper arm)
0.582 0.418 0.000
M65.11 Other infective (teno)synovitis (Shoulder region)
0.582 0.418 0.000
M65.10 Other infective (teno)synovitis (Multiple sites)
0.582 0.418 0.000
M13.1 Monoarthritis, not elsewhere classified
0.581 0.419 0.000
D53 Other nutritional anaemias
0.000 0.421 0.579
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.579 0.421 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.422 0.578
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.422 0.578
K90.1 Tropical sprue
0.000 0.422 0.578
M91-M94 Chondropathies
0.576 0.424 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.576 0.424 0.000
J11.1 Influenza with other respiratory manifestations, virus not identified
0.575 0.425 0.000
M40-M43 Deforming dorsopathies
0.574 0.426 0.000
E28 Ovarian dysfunction
0.002 0.428 0.571
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.429 0.571
J35.9 Chronic disease of tonsils and adenoids, unspecified
0.569 0.431 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.432 0.568
D58 Other hereditary haemolytic anaemias
0.000 0.433 0.566
M46.47 Discitis, unspecified (Lumbosacral region)
0.565 0.435 0.000
M14.8 Arthropathies in other specified diseases classified elsewhere
0.565 0.435 0.000
E13.8 With unspecified complications
0.565 0.435 0.000
E13.7 With multiple complications
0.565 0.435 0.000
E13.6 With other specified complications
0.565 0.435 0.000
E13.5 With peripheral circulatory complications
0.565 0.435 0.000
E13.4 With neurological complications
0.565 0.435 0.000
E13.2 With renal complications
0.565 0.435 0.000
E13.1 With ketoacidosis
0.565 0.435 0.000
E13.0 With coma
0.565 0.435 0.000
J96 Respiratory failure, not elsewhere classified
0.563 0.437 0.000
J12.2 Parainfluenza virus pneumonia
0.561 0.439 0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.440 0.560
M99 Biomechanical lesions, not elsewhere classified
0.559 0.441 0.000
M46.46 Discitis, unspecified (Lumbar region)
0.559 0.441 0.000
E11.3 With ophthalmic complications
0.559 0.441 0.000
M21.1 Varus deformity, not elsewhere classified
0.556 0.444 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.021 0.444 0.535
M11 Other crystal arthropathies
0.553 0.447 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.451 0.549
D69.5 Secondary thrombocytopenia
0.000 0.452 0.548
M03 Postinfective and reactive arthropathies in diseases classified elsewhere
0.547 0.453 0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere
0.547 0.453 0.000
M21.3 Wrist or foot drop (acquired)
0.545 0.455 0.000
M05.29 Rheumatoid vasculitis (Site unspecified)
0.544 0.456 0.000
M05.28 Rheumatoid vasculitis (Other)
0.544 0.456 0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)
0.544 0.456 0.000
M05.26 Rheumatoid vasculitis (Lower leg)
0.544 0.456 0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)
0.544 0.456 0.000
M05.24 Rheumatoid vasculitis (Hand)
0.544 0.456 0.000
M05.23 Rheumatoid vasculitis (Forearm)
0.544 0.456 0.000
M05.22 Rheumatoid vasculitis (Upper arm)
0.544 0.456 0.000
M05.21 Rheumatoid vasculitis (Shoulder region)
0.544 0.456 0.000
J12.1 Respiratory syncytial virus pneumonia
0.542 0.458 0.000
M66.0 Rupture of popliteal cyst
0.541 0.458 0.000
E40-E46 Malnutrition
0.400 0.462 0.138
M65.84 Other synovitis and tenosynovitis (Hand)
0.538 0.462 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.462 0.538
M12.39 Palindromic rheumatism (Site unspecified)
0.537 0.463 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.535 0.465 0.000
M06.88 Other specified rheumatoid arthritis (Other)
0.534 0.465 0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.534 0.465 0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.534 0.465 0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.534 0.465 0.000
M06.84 Other specified rheumatoid arthritis (Hand)
0.534 0.465 0.000
M06.83 Other specified rheumatoid arthritis (Forearm)
0.534 0.465 0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.534 0.465 0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.534 0.465 0.000
M21.6 Other acquired deformities of ankle and foot
0.531 0.469 0.000
J85.1 Abscess of lung with pneumonia
0.531 0.469 0.000
D68.9 Coagulation defect, unspecified
0.000 0.469 0.531

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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