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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2421847
log Bayes Factor = 1.0897
Chromosome 1   position 171,557,600  (GRCh37) Explore rs2421847 on Ensembl!
Variant rs2421847 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E11 Non-insulin-dependent diabetes mellitus
0.000 0.097 0.903
E10-E14 Diabetes mellitus
0.000 0.099 0.901
E11.9 Without complications
0.000 0.099 0.901
E14 Unspecified diabetes mellitus
0.000 0.120 0.880
E14.9 Without complications
0.000 0.136 0.864
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.156 0.844
E65-E68 Obesity and other hyperalimentation
0.000 0.161 0.839
E66 Obesity
0.000 0.163 0.837
E66.9 Obesity, unspecified
0.000 0.169 0.831
E11.4 With neurological complications
0.000 0.170 0.830
E10 Insulin-dependent diabetes mellitus
0.000 0.177 0.823
E66.8 Other obesity
0.000 0.266 0.734
E70-E90 Metabolic disorders
0.000 0.276 0.724
E10.3 With ophthalmic complications
0.000 0.280 0.720
E11.3 With ophthalmic complications
0.000 0.300 0.700
E86 Volume depletion
0.000 0.316 0.684
E10.9 Without complications
0.000 0.341 0.659
E11.8 With unspecified complications
0.000 0.352 0.647
E11.7 With multiple complications
0.000 0.352 0.647
E11.6 With other specified complications
0.000 0.352 0.647
E11.1 With ketoacidosis
0.000 0.352 0.647
E12 Malnutrition-related diabetes mellitus
0.000 0.354 0.646
E10.1 With ketoacidosis
0.000 0.361 0.639
E14.8 With unspecified complications
0.000 0.369 0.631
E14.7 With multiple complications
0.000 0.369 0.631
E14.6 With other specified complications
0.000 0.369 0.631
E14.5 With peripheral circulatory complications
0.000 0.369 0.631
E14.4 With neurological complications
0.000 0.369 0.631
E14.2 Withrenal complications
0.000 0.369 0.631
E14.1 With ketoacidosis
0.000 0.369 0.631
E14.0 With coma
0.000 0.369 0.631
E50-E64 Other nutritional deficiencies
0.000 0.373 0.627
E14.3 With ophthalmic complications
0.000 0.375 0.625
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.383 0.617
E11.5 With peripheral circulatory complications
0.000 0.383 0.617
E11.0 With coma
0.000 0.392 0.608
E10.5 With peripheral circulatory complications
0.000 0.392 0.607
E11.2 With renal complications
0.000 0.394 0.606
E67 Other hyperalimentation
0.000 0.398 0.602
E68 Sequelae of hyperalimentation
0.000 0.398 0.602
E65 Localised adiposity
0.000 0.398 0.602
E10.4 With neurological complications
0.000 0.398 0.602
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.400 0.600
E66.1 Drug-induced obesity
0.000 0.400 0.600
E66.0 Obesity due to excess calories
0.000 0.400 0.600
E40-E46 Malnutrition
0.000 0.402 0.598
E10.8 With unspecified complications
0.000 0.410 0.590
E10.7 With multiple complications
0.000 0.410 0.590
E10.6 With other specified complications
0.000 0.410 0.590
E10.0 With coma
0.000 0.410 0.590
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.415 0.585
E20-E35 Disorders of other endocrine glands
0.001 0.427 0.572
E10.2 With renal complications
0.000 0.436 0.563
E80.4 Gilbert's syndrome
0.000 0.459 0.541
E87.2 Acidosis
0.000 0.465 0.535
E13 Other specified diabetes mellitus
0.000 0.471 0.529
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.476 0.524
E88 Other metabolic disorders
0.000 0.477 0.523
E84 Cystic fibrosis
0.000 0.481 0.519
E79 Disorders of purine and pyrimidine metabolism
0.000 0.481 0.519
E77 Disorders of glycoprotein metabolism
0.000 0.481 0.519
E76 Disorders of glycosaminoglycan metabolism
0.000 0.481 0.519
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.481 0.519
E74 Other disorders of carbohydrate metabolism
0.000 0.481 0.519
E72 Other disorders of amino-acid metabolism
0.000 0.481 0.519
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.481 0.519
E70 Disorders of aromatic amino-acid metabolism
0.000 0.481 0.519
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.481 0.519
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.485 0.515
E73 Lactose intolerance
0.000 0.488 0.511
E83 Disorders of mineral metabolism
0.000 0.496 0.504
E23 Hypofunction and other disorders of pituitary gland
0.000 0.498 0.501
E87.0 Hyperosmolality and hypernatraemia
0.000 0.512 0.488
E53 Deficiency of other B group vitamins
0.000 0.514 0.486
E61 Deficiency of other nutrient elements
0.000 0.526 0.474
E12.9 Without complications
0.000 0.536 0.463
E12.8 With unspecified complications
0.000 0.536 0.463
E12.7 With multiple complications
0.000 0.536 0.463
E12.6 With other specified complications
0.000 0.536 0.463
E12.5 With peripheral circulatory complications
0.000 0.536 0.463
E12.4 With neurological complications
0.000 0.536 0.463
E12.3 With ophthalmic complications
0.000 0.536 0.463
E12.2 With renal complications
0.000 0.536 0.463
E12.1 With ketoacidosis
0.000 0.536 0.463
E12.0 With coma
0.000 0.536 0.463
E23.0 Hypopituitarism
0.000 0.550 0.450
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.550 0.450
E63 Other nutritional deficiencies
0.000 0.550 0.450
E56 Other vitamin deficiencies
0.000 0.550 0.450
E51 Thiamine deficiency
0.000 0.550 0.450
E50 Vitamin A deficiency
0.000 0.550 0.450
E60 Dietary zinc deficiency
0.000 0.550 0.450
E59 Dietary selenium deficiency
0.000 0.550 0.450
E58 Dietary calcium deficiency
0.000 0.550 0.450
E54 Ascorbic acid deficiency
0.000 0.550 0.450
E52 Niacin deficiency [pellagra]
0.000 0.550 0.450
E22 Hyperfunction of pituitary gland
0.000 0.551 0.449
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.554 0.446
E83.1 Disorders of iron metabolism
0.000 0.554 0.446
E85 Amyloidosis
0.000 0.557 0.443
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.557 0.443
E80.6 Other disorders of bilirubin metabolism
0.000 0.557 0.443
E80.5 Crigler-Najjar syndrome
0.000 0.557 0.443
E80.3 Defects of catalase and peroxydase
0.000 0.557 0.443
E80.2 Other porphyria
0.000 0.557 0.443
E80.1 Porphyria cutanea tarda
0.000 0.557 0.443
E80.0 Hereditary erythropoietic porphyria
0.000 0.557 0.443
E28 Ovarian dysfunction
0.000 0.565 0.435
E67.8 Other specified hyperalimentation
0.000 0.568 0.431
E67.3 Hypervitaminosis D
0.000 0.568 0.431
E67.2 Megavitamin-B6 syndrome
0.000 0.568 0.431
E67.1 Hypercarotenaemia
0.000 0.568 0.431
E67.0 Hypervitaminosis A
0.000 0.568 0.431
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.571 0.429
E45 Retarded development following protein-energy malnutrition
0.000 0.571 0.429
E43 Unspecified severe protein-energy malnutrition
0.000 0.571 0.429
E42 Marasmic kwashiorkor
0.000 0.571 0.429
E41 Nutritional marasmus
0.000 0.571 0.429
E40 Kwashiorkor
0.000 0.571 0.429
E46 Unspecified protein-energy malnutrition
0.000 0.578 0.422
E87.4 Mixed disorder of acid-base balance
0.000 0.580 0.420
E87.3 Alkalosis
0.000 0.582 0.417
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.583 0.416
E35 Disorders of endocrine glands in diseases classified elsewhere
0.001 0.589 0.410
E34 Other endocrine disorders
0.001 0.589 0.410
E32 Diseases of thymus
0.001 0.589 0.410
E31 Polyglandular dysfunction
0.001 0.589 0.410
E30 Disorders of puberty, not elsewhere classified
0.001 0.589 0.410
E25 Adrenogenital disorders
0.001 0.589 0.410
E20 Hypoparathyroidism
0.001 0.589 0.410
E24 Cushing's syndrome
0.001 0.598 0.401
E55 Vitamin D deficiency
0.000 0.599 0.401
E27 Other disorders of adrenal gland
0.001 0.606 0.394
E53.8 Deficiency of other specified B group vitamins
0.000 0.616 0.384
E13.8 With unspecified complications
0.000 0.620 0.379
E13.7 With multiple complications
0.000 0.620 0.379
E13.6 With other specified complications
0.000 0.620 0.379
E13.5 With peripheral circulatory complications
0.000 0.620 0.379
E13.4 With neurological complications
0.000 0.620 0.379
E13.3 With ophthalmic complications
0.000 0.620 0.379
E13.2 With renal complications
0.000 0.620 0.379
E13.1 With ketoacidosis
0.000 0.620 0.379
E13.0 With coma
0.000 0.620 0.379
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.621 0.379
E26 Hyperaldosteronism
0.001 0.623 0.377
E15 Nondiabetic hypoglycaemic coma
0.000 0.624 0.376
E88.9 Metabolic disorder, unspecified
0.000 0.625 0.375
E88.8 Other specified metabolic disorders
0.000 0.625 0.375
E88.3 Tumour lysis syndrome
0.000 0.625 0.375
E88.2 Lipomatosis, not elsewhere classified
0.000 0.625 0.375
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.625 0.375
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.627 0.372
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.627 0.372
E70.3 Albinism
0.000 0.627 0.372
E70.2 Disorders of tyrosine metabolism
0.000 0.627 0.372
E70.1 Other hyperphenylalaninaemias
0.000 0.627 0.372
E70.0 Classical phenylketonuria
0.000 0.627 0.372
E71.3 Disorders of fatty-acid metabolism
0.000 0.627 0.372
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.627 0.372
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.627 0.372
E71.0 Maple-syrup-urine disease
0.000 0.627 0.372
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.627 0.372
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.627 0.372
E72.5 Disorders of glycine metabolism
0.000 0.627 0.372
E72.4 Disorders of ornithine metabolism
0.000 0.627 0.372
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.627 0.372
E72.2 Disorders of urea cycle metabolism
0.000 0.627 0.372
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.627 0.372
E72.0 Disorders of amino-acid transport
0.000 0.627 0.372
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.627 0.372
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.627 0.372
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.627 0.372
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.627 0.372
E74.2 Disorders of galactose metabolism
0.000 0.627 0.372
E74.1 Disorders of fructose metabolism
0.000 0.627 0.372
E74.0 Glycogen storage disease
0.000 0.627 0.372
E75.6 Lipid storage disorder, unspecified
0.000 0.627 0.372
E75.5 Other lipid storage disorders
0.000 0.627 0.372
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.627 0.372
E75.3 Sphingolipidosis, unspecified
0.000 0.627 0.372
E75.2 Other sphingolipidosis
0.000 0.627 0.372
E75.1 Other gangliosidosis
0.000 0.627 0.372
E75.0 GM2 gangliosidosis
0.000 0.627 0.372
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.627 0.372
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.627 0.372
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.627 0.372
E76.2 Other mucopolysaccharidoses
0.000 0.627 0.372
E76.1 Mucopolysaccharidosis, type II
0.000 0.627 0.372
E76.0 Mucopolysaccharidosis, type I
0.000 0.627 0.372
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.627 0.372
E77.8 Other disorders of glycoprotein metabolism
0.000 0.627 0.372
E77.1 Defects in glycoprotein degradation
0.000 0.627 0.372
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.627 0.372
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.627 0.372
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.627 0.372
E79.1 Lesch-Nyhan syndrome
0.000 0.627 0.372
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.627 0.372
E84.9 Cystic fibrosis, unspecified
0.000 0.627 0.372
E84.8 Cystic fibrosis with other manifestations
0.000 0.627 0.372
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.627 0.372
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.627 0.372
E29 Testicular dysfunction
0.001 0.631 0.368
E73.8 Other lactose intolerance
0.000 0.633 0.367
E73.1 Secondary lactase deficiency
0.000 0.633 0.367
E73.0 Congenital lactase deficiency
0.000 0.633 0.367
E61.1 Iron deficiency
0.000 0.635 0.365
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.638 0.362
E83.8 Other disorders of mineral metabolism
0.000 0.638 0.362
E83.2 Disorders of zinc metabolism
0.000 0.638 0.362
E83.0 Disorders of copper metabolism
0.000 0.638 0.362
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.640 0.360
E23.7 Disorder of pituitary gland, unspecified
0.000 0.640 0.359
E23.6 Other disorders of pituitary gland
0.000 0.640 0.359
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.640 0.359
E23.2 Diabetes insipidus
0.000 0.640 0.359
E23.1 Drug-induced hypopituitarism
0.000 0.640 0.359
E73.9 Lactose intolerance, unspecified
0.000 0.641 0.359
E53.9 Vitamin B deficiency, unspecified
0.000 0.652 0.348
E53.1 Pyridoxine deficiency
0.000 0.652 0.348
E53.0 Riboflavin deficiency
0.000 0.652 0.348
E61.9 Deficiency of nutrient element, unspecified
0.000 0.660 0.340
E61.8 Deficiency of other specified nutrient elements
0.000 0.660 0.340
E61.7 Deficiency of multiple nutrient elements
0.000 0.660 0.340
E61.6 Vanadium deficiency
0.000 0.660 0.340
E61.5 Molybdenum deficiency
0.000 0.660 0.340
E61.4 Chromium deficiency
0.000 0.660 0.340
E61.3 Manganese deficiency
0.000 0.660 0.340
E61.2 Magnesium deficiency
0.000 0.660 0.340
E61.0 Copper deficiency
0.000 0.660 0.340
E28.2 Polycystic ovarian syndrome
0.000 0.663 0.337
E83.3 Disorders of phosphorus metabolism
0.000 0.663 0.337
E50.9 Vitamin A deficiency, unspecified
0.000 0.677 0.322
E50.8 Other manifestations of vitamin A deficiency
0.000 0.677 0.322
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.677 0.322
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.677 0.322
E50.5 Vitamin A deficiency with night blindness
0.000 0.677 0.322
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.677 0.322
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.677 0.322
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.677 0.322
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.677 0.322
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.677 0.322
E51.9 Thiamine deficiency, unspecified
0.000 0.677 0.322
E51.8 Other manifestations of thiamine deficiency
0.000 0.677 0.322
E51.2 Wernicke's encephalopathy
0.000 0.677 0.322
E51.1 Beriberi
0.000 0.677 0.322
E56.9 Vitamin deficiency, unspecified
0.000 0.677 0.322
E56.8 Deficiency of other vitamins
0.000 0.677 0.322
E56.1 Deficiency of vitamin K
0.000 0.677 0.322
E56.0 Deficiency of vitamin E
0.000 0.677 0.322
E63.9 Nutritional deficiency, unspecified
0.000 0.677 0.322
E63.8 Other specified nutritional deficiencies
0.000 0.677 0.322
E63.1 Imbalance of constituents of food intake
0.000 0.677 0.322
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.677 0.322
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.677 0.322
E64.8 Sequelae of other nutritional deficiencies
0.000 0.677 0.322
E64.3 Sequelae of rickets
0.000 0.677 0.322
E64.2 Sequelae of vitamin C deficiency
0.000 0.677 0.322
E64.1 Sequelae of vitamin A deficiency
0.000 0.677 0.322
E64.0 Sequelae of protein-energy malnutrition
0.000 0.677 0.322
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.678 0.322
E22.8 Other hyperfunction of pituitary gland
0.000 0.678 0.322
E22.1 Hyperprolactinaemia
0.000 0.678 0.322
E22.0 Acromegaly and pituitary gigantism
0.000 0.678 0.322
E85.8 Other amyloidosis
0.000 0.682 0.318
E85.3 Secondary systemic amyloidosis
0.000 0.682 0.318
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.682 0.318
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.682 0.318
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.682 0.318
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.684 0.315
E28.9 Ovarian dysfunction, unspecified
0.000 0.688 0.312
E28.8 Other ovarian dysfunction
0.000 0.688 0.312
E28.3 Primary ovarian failure
0.000 0.688 0.312
E28.1 Androgen excess
0.000 0.688 0.312
E28.0 Oestrogen excess
0.000 0.688 0.312
E27.1 Primary adrenocortical insufficiency
0.000 0.690 0.310
E44.1 Mild protein-energy malnutrition
0.000 0.692 0.308
E44.0 Moderate protein-energy malnutrition
0.000 0.692 0.308
E83.5 Disorders of calcium metabolism
0.000 0.699 0.301
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.701 0.299
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.701 0.299
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.701 0.299
E89.5 Postprocedural testicular hypofunction
0.000 0.701 0.299
E89.4 Postprocedural ovarian failure
0.000 0.701 0.299
E89.3 Postprocedural hypopituitarism
0.000 0.701 0.299
E89.2 Postprocedural hypoparathyroidism
0.000 0.701 0.299
E89.1 Postprocedural hypoinsulinaemia
0.000 0.701 0.299
E16 Other disorders of pancreatic internal secretion
0.000 0.705 0.295
E20.9 Hypoparathyroidism, unspecified
0.001 0.705 0.294
E20.8 Other hypoparathyroidism
0.001 0.705 0.294
E20.1 Pseudohypoparathyroidism
0.001 0.705 0.294
E20.0 Idiopathic hypoparathyroidism
0.001 0.705 0.294
E25.9 Adrenogenital disorder, unspecified
0.001 0.705 0.294
E25.8 Other adrenogenital disorders
0.001 0.705 0.294
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.705 0.294
E30.9 Disorder of puberty, unspecified
0.001 0.705 0.294
E30.8 Other disorders of puberty
0.001 0.705 0.294
E30.1 Precocious puberty
0.001 0.705 0.294
E30.0 Delayed puberty
0.001 0.705 0.294
E31.9 Polyglandular dysfunction, unspecified
0.001 0.705 0.294
E31.8 Other polyglandular dysfunction
0.001 0.705 0.294
E31.1 Polyglandular hyperfunction
0.001 0.705 0.294
E31.0 Autoimmune polyglandular failure
0.001 0.705 0.294
E32.9 Disease of thymus, unspecified
0.001 0.705 0.294
E32.8 Other diseases of thymus
0.001 0.705 0.294
E32.1 Abscess of thymus
0.001 0.705 0.294
E32.0 Persistent hyperplasia of thymus
0.001 0.705 0.294
E34.9 Endocrine disorder, unspecified
0.001 0.705 0.294
E34.8 Other specified endocrine disorders
0.001 0.705 0.294
E34.5 Androgen resistance syndrome
0.001 0.705 0.294
E34.4 Constitutional tall stature
0.001 0.705 0.294
E34.3 Short stature, not elsewhere classified
0.001 0.705 0.294
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.705 0.294
E34.1 Other hypersecretion of intestinal hormones
0.001 0.705 0.294
E34.0 Carcinoid syndrome
0.001 0.705 0.294
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.001 0.705 0.294
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.001 0.705 0.294
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.001 0.705 0.294
E24.8 Other Cushing's syndrome
0.001 0.712 0.288
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.001 0.712 0.288
E24.3 Ectopic ACTH syndrome
0.001 0.712 0.288
E24.2 Drug-induced Cushing's syndrome
0.001 0.712 0.288
E24.1 Nelson's syndrome
0.001 0.712 0.288
E24.0 Pituitary-dependent Cushing's disease
0.001 0.712 0.288
E55.0 Rickets, active
0.000 0.712 0.288
E85.4 Organ-limited amyloidosis
0.000 0.712 0.287
E27.5 Adrenomedullary hyperfunction
0.001 0.717 0.282
E27.3 Drug-induced adrenocortical insufficiency
0.001 0.717 0.282
E27.2 Addisonian crisis
0.001 0.717 0.282
E27.0 Other adrenocortical overactivity
0.001 0.717 0.282
E85.9 Amyloidosis, unspecified
0.000 0.719 0.281
E24.9 Cushing's syndrome, unspecified
0.001 0.721 0.278
E83.4 Disorders of magnesium metabolism
0.000 0.726 0.274
E26.9 Hyperaldosteronism, unspecified
0.001 0.729 0.270
E26.8 Other hyperaldosteronism
0.001 0.729 0.270
E26.1 Secondary hyperaldosteronism
0.001 0.729 0.270
E87.7 Fluid overload
0.000 0.734 0.265
E29.9 Testicular dysfunction, unspecified
0.001 0.736 0.264
E29.8 Other testicular dysfunction
0.001 0.736 0.264
E29.0 Testicular hyperfunction
0.001 0.736 0.264
E13.9 Without complications
0.001 0.737 0.262
E87.5 Hyperkalaemia
0.000 0.743 0.256
E27.9 Disorder of adrenal gland, unspecified
0.001 0.753 0.246
E55.9 Vitamin D deficiency, unspecified
0.000 0.761 0.239
E26.0 Primary hyperaldosteronism
0.001 0.763 0.237
E29.1 Testicular hypofunction
0.001 0.778 0.221
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.788 0.212
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.788 0.212
E16.4 Abnormal secretion of gastrin
0.000 0.788 0.212
E16.3 Increased secretion of glucagon
0.000 0.788 0.212
E16.1 Other hypoglycaemia
0.000 0.788 0.212
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.788 0.212
E27.8 Other specified disorders of adrenal gland
0.001 0.789 0.210
E89.0 Postprocedural hypothyroidism
0.000 0.804 0.196
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.003 0.807 0.189
E87.6 Hypokalaemia
0.000 0.814 0.185
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.827 0.173
E00-E07 Disorders of thyroid gland
0.000 0.828 0.172
E21.5 Disorder of parathyroid gland, unspecified
0.002 0.862 0.136
E21.4 Other specified disorders of parathyroid gland
0.002 0.862 0.136
E21.2 Other hyperparathyroidism
0.002 0.862 0.136
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.002 0.862 0.136
E16.2 Hypoglycaemia, unspecified
0.000 0.869 0.131
E78.6 Lipoprotein deficiency
0.000 0.876 0.124
E78.4 Other hyperlipidaemia
0.000 0.876 0.124
E78.3 Hyperchylomicronaemia
0.000 0.876 0.124
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.877 0.123
E00 Congenital iodine-deficiency syndrome
0.000 0.877 0.123
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.877 0.123
E78.8 Other disorders of lipoprotein metabolism
0.000 0.879 0.121
E78.1 Pure hyperglyceridaemia
0.000 0.884 0.115
E06 Thyroiditis
0.000 0.887 0.113
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.890 0.110
K92.1 Melaena
0.000 0.891 0.109
E78.2 Mixed hyperlipidaemia
0.000 0.893 0.106
K92 Other diseases of digestive system
0.000 0.895 0.105
K92.2 Gastro-intestinal haemorrhage, unspecified
0.000 0.897 0.103
K92.0 Haematemesis
0.000 0.904 0.096
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.904 0.096
E21.3 Hyperparathyroidism, unspecified
0.003 0.906 0.091
E07 Other disorders of thyroid
0.000 0.911 0.089
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.911 0.088
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.911 0.088
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.911 0.088
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.911 0.088
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.911 0.088
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.911 0.088
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.911 0.088
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.911 0.088
E04 Other non-toxic goitre
0.000 0.912 0.088
E03 Other hypothyroidism
0.000 0.914 0.086
E06.9 Thyroiditis, unspecified
0.000 0.919 0.081
E06.5 Other chronic thyroiditis
0.000 0.919 0.081
E06.4 Drug-induced thyroiditis
0.000 0.919 0.081
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.919 0.081
E06.1 Subacute thyroiditis
0.000 0.919 0.081
E06.0 Acute thyroiditis
0.000 0.919 0.081
E78.0 Pure hypercholesterolaemia
0.000 0.920 0.080
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.925 0.075
E78.5 Hyperlipidaemia, unspecified
0.000 0.925 0.075
K92.8 Other specified diseases of digestive system
0.000 0.925 0.075
E04.9 Non-toxic goitre, unspecified
0.000 0.928 0.071
E06.3 Autoimmune thyroiditis
0.000 0.929 0.070
E05.8 Other thyrotoxicosis
0.000 0.931 0.069
E05.5 Thyroid crisis or storm
0.000 0.931 0.069
E05.4 Thyrotoxicosis factitia
0.000 0.931 0.069
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.931 0.069
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.931 0.069
E07.1 Dyshormogenetic goitre
0.000 0.936 0.064
E07.0 Hypersecretion of calcitonin
0.000 0.936 0.064
E04.8 Other specified non-toxic goitre
0.000 0.937 0.063
E03.5 Myxoedema coma
0.000 0.938 0.062
E03.4 Atrophy of thyroid (acquired)
0.000 0.938 0.062
E03.3 Postinfectious hypothyroidism
0.000 0.938 0.062
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.938 0.062
E03.1 Congenital hypothyroidism without goitre
0.000 0.938 0.062
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.938 0.062
E03.8 Other specified hypothyroidism
0.000 0.939 0.061
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.940 0.060
E04.0 Non-toxic diffuse goitre
0.000 0.943 0.057
E07.8 Other specified disorders of thyroid
0.001 0.944 0.056
K92.9 Disease of digestive system, unspecified
0.000 0.945 0.054
E04.1 Non-toxic single thyroid nodule
0.000 0.952 0.048
E21.0 Primary hyperparathyroidism
0.005 0.955 0.040
E07.9 Disorder of thyroid, unspecified
0.001 0.957 0.043
E04.2 Non-toxic multinodular goitre
0.000 0.957 0.042
E05.9 Thyrotoxicosis, unspecified
0.000 0.959 0.041
K90-K93 Other diseases of the digestive system
0.000 0.963 0.037
K90 Intestinal malabsorption
0.000 0.971 0.029
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.973 0.027
E03.9 Hypothyroidism, unspecified
0.000 0.974 0.026
K90.0 Coeliac disease
0.000 0.977 0.023
Z91.5 Personal history of self-harm
0.022 0.978 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.979 0.021
K90.8 Other intestinal malabsorption
0.000 0.979 0.021
K90.3 Pancreatic steatorrhoea
0.000 0.979 0.021
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.979 0.021
K90.1 Tropical sprue
0.000 0.979 0.021
K90.9 Intestinal malabsorption, unspecified
0.000 0.979 0.021
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.981 0.019
K93.1 Megacolon in Chagas' disease
0.000 0.981 0.019
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.981 0.019
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.981 0.019
N39.3 Stress incontinence
0.000 0.982 0.018
N39 Other disorders of urinary system
0.000 0.984 0.016
N39.9 Disorder of urinary system, unspecified
0.000 0.984 0.016
N39.4 Other specified urinary incontinence
0.000 0.985 0.015
K91.4 Colostomy and enterostomy malfunction
0.000 0.985 0.015
K91.9 Postprocedural disorder of digestive system, unspecified
0.000 0.986 0.014
K91.5 Postcholecystectomy syndrome
0.000 0.986 0.014
K91.2 Postsurgical malabsorption, not elsewhere classified
0.000 0.986 0.014
K91.1 Postgastric surgery syndromes
0.000 0.986 0.014
N39.8 Other specified disorders of urinary system
0.000 0.987 0.013
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.000 0.987 0.013
K91.0 Vomiting following gastro-intestinal surgery
0.000 0.987 0.013
N39.2 Orthostatic proteinuria, unspecified
0.000 0.988 0.012
N39.1 Persistent proteinuria, unspecified
0.000 0.988 0.012
K91.3 Postoperative intestinal obstruction
0.000 0.990 0.010
D25.2 Subserosal leiomyoma of uterus
0.009 0.991 0.000
N32.0 Bladder-neck obstruction
0.000 0.991 0.009
Z93.3 Colostomy status
0.000 0.992 0.008
Z93 Artificial opening status
0.000 0.993 0.007
N30-N39 Other diseases of urinary system
0.000 0.994 0.006
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.000 0.994 0.006
Z93.5 Cystostomy status
0.000 0.994 0.006
N31.9 Neuromuscular dysfunction of bladder, unspecified
0.000 0.994 0.006
N32 Other disorders of bladder
0.000 0.994 0.006
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.006 0.994 0.000
Y52 Agents primarily affecting the cardiovascular system
0.006 0.994 0.000
Z93.1 Gastrostomy status
0.000 0.994 0.006
N31.2 Flaccid neuropathic bladder, not elsewhere classified
0.000 0.994 0.006
Z93.0 Tracheostomy status
0.000 0.994 0.005
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.005 0.995 0.000
Z93.4 Other artificial openings of gastro-intestinal tract status
0.000 0.995 0.005
Z93.6 Other artificial openings of urinary tract status
0.000 0.995 0.005
Z93.9 Artificial opening status, unspecified
0.000 0.995 0.005
Z93.8 Other artificial opening status
0.000 0.995 0.005
Z93.2 Ileostomy status
0.000 0.995 0.005
Y52.3 Coronary vasodilators, not elsewhere classified
0.005 0.995 0.000
Y52.1 Calcium-channel blockers
0.005 0.995 0.000
F33 Recurrent depressive disorder
0.005 0.995 0.000
Y43.3 Other antineoplastic drugs
0.005 0.995 0.000
N37 Urethral disorders in diseases classified elsewhere
0.000 0.995 0.005
N33 Bladder disorders in diseases classified elsewhere
0.000 0.995 0.005
N31.1 Reflex neuropathic bladder, not elsewhere classified
0.000 0.995 0.005
N31.0 Uninhibited neuropathic bladder, not elsewhere classified
0.000 0.995 0.005
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.005 0.995 0.000
N31.8 Other neuromuscular dysfunction of bladder
0.000 0.995 0.005
O26 Maternal care for other conditions predominantly related to pregnancy
0.005 0.995 0.000
N32.1 Vesicointestinal fistula
0.000 0.995 0.004
Y43 Primarily systemic agents
0.005 0.995 0.000
N32.4 Rupture of bladder, nontraumatic
0.000 0.995 0.004
N32.2 Vesical fistula, not elsewhere classified
0.000 0.995 0.004
N34 Urethritis and urethral syndrome
0.000 0.995 0.004
F30-F39 Mood [affective] disorders
0.004 0.996 0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
0.004 0.996 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.004 0.996 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.004 0.996 0.000
Y52.7 Peripheral vasodilators
0.004 0.996 0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.004 0.996 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.004 0.996 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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