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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2516436
log Bayes Factor = 118.677
Chromosome 6   position 31,419,877  (GRCh37) Explore rs2516436 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
M45 Ankylosing spondylitis
0.000 0.005 0.995
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.010 0.990
E10 Insulin-dependent diabetes mellitus
0.000 0.017 0.983
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.017 0.983
C85.1 B-cell lymphoma, unspecified
0.000 0.018 0.982
E10.9 Without complications
0.000 0.019 0.981
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.020 0.980
E10-E14 Diabetes mellitus
0.000 0.026 0.974
J45.9 Asthma, unspecified
0.000 0.030 0.970
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.037 0.963
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.038 0.962
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.044 0.956
E14 Unspecified diabetes mellitus
0.000 0.045 0.955
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.048 0.952
E10.3 With ophthalmic complications
0.000 0.050 0.950
E14.3 With ophthalmic complications
0.000 0.054 0.946
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.066 0.934
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.078 0.922
C83.3 Large cell (diffuse)
0.000 0.080 0.920
E07 Other disorders of thyroid
0.000 0.098 0.902
E10.2 With renal complications
0.000 0.106 0.894
E10.1 With ketoacidosis
0.000 0.126 0.874
E83.1 Disorders of iron metabolism
0.870 0.130 0.000
E03.8 Other specified hypothyroidism
0.000 0.146 0.854
E07.9 Disorder of thyroid, unspecified
0.000 0.153 0.847
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.183 0.817
C82.3 Follicular lymphoma grade IIIa
0.000 0.194 0.806
E06 Thyroiditis
0.000 0.214 0.786
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.217 0.783
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.228 0.772
E14.2 Withrenal complications
0.000 0.232 0.768
C82.2 Large cell, follicular
0.000 0.232 0.768
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.236 0.764
C83.7 Burkitt's tumour
0.000 0.253 0.747
C82.0 Small cleaved cell, follicular
0.000 0.266 0.734
E10.7 With multiple complications
0.000 0.276 0.724
E10.4 With neurological complications
0.000 0.276 0.724
E10.8 With unspecified complications
0.000 0.278 0.721
E05.8 Other thyrotoxicosis
0.000 0.279 0.721
C81 Hodgkin's disease
0.000 0.282 0.718
E14.5 With peripheral circulatory complications
0.000 0.282 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.286 0.714
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.286 0.714
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.286 0.714
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.286 0.714
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.286 0.714
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.286 0.714
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.289 0.711
C82.4 Follicular lymphoma grade IIIb
0.000 0.290 0.710
E14.1 With ketoacidosis
0.000 0.296 0.704
E14.8 With unspecified complications
0.000 0.297 0.703
C86 Other specified types of T/NK-cell lymphoma
0.000 0.299 0.701
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.301 0.699
E12 Malnutrition-related diabetes mellitus
0.000 0.301 0.698
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.308 0.692
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.309 0.690
C82.6 Cutaneous follicle centre lymphoma
0.000 0.310 0.689
C82.5 Diffuse follicle centre lymphoma
0.000 0.310 0.689
E10.6 With other specified complications
0.000 0.311 0.689
E14.7 With multiple complications
0.000 0.315 0.685
E14.6 With other specified complications
0.000 0.319 0.681
C88 Malignant immunoproliferative diseases
0.000 0.321 0.679
C84.5 Other and unspecified T-cell lymphomas
0.000 0.327 0.673
C84.8 Cutaneous T-cell lymphoma, unspecified
0.000 0.334 0.666
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.335 0.665
E14.0 With coma
0.000 0.338 0.661
C83.6 Undifferentiated (diffuse)
0.000 0.339 0.661
C83.5 Lymphoblastic (diffuse)
0.000 0.339 0.661
C83.4 Immunoblastic (diffuse)
0.000 0.339 0.661
C83.2 Mixed small and large cell (diffuse)
0.000 0.339 0.661
C85.0 Lymphosarcoma
0.000 0.340 0.660
E14.4 With neurological complications
0.000 0.341 0.659
E03.1 Congenital hypothyroidism without goitre
0.000 0.350 0.650
E07.1 Dyshormogenetic goitre
0.000 0.353 0.647
E07.0 Hypersecretion of calcitonin
0.000 0.353 0.647
E06.3 Autoimmune thyroiditis
0.000 0.359 0.641
C94 Other leukaemias of specified cell type
0.000 0.363 0.636
E13 Other specified diabetes mellitus
0.000 0.365 0.635
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.375 0.625
C84.0 Mycosis fungoides
0.000 0.376 0.624
C81.9 Hodgkin's disease, unspecified
0.000 0.382 0.618
C83.1 Small cleaved cell (diffuse)
0.000 0.390 0.610
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.400 0.600
E06.5 Other chronic thyroiditis
0.000 0.401 0.599
E10.5 With peripheral circulatory complications
0.000 0.402 0.598
C84.9 Mature T/NK-cell lymphoma, unspecified
0.000 0.414 0.586
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.000 0.414 0.586
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.000 0.414 0.586
C84.3 Lymphoepithelioid lymphoma
0.000 0.414 0.586
C84.2 T-zone lymphoma
0.000 0.414 0.586
C84.1 Sezary's diease
0.000 0.414 0.586
E10.0 With coma
0.000 0.417 0.583
C93 Monocytic leukaemia
0.000 0.419 0.581
E07.8 Other specified disorders of thyroid
0.000 0.421 0.579
E40-E46 Malnutrition
0.000 0.423 0.576
E06.4 Drug-induced thyroiditis
0.000 0.436 0.564
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.436 0.564
E06.0 Acute thyroiditis
0.000 0.436 0.564
C91 Lymphoid leukaemia
0.000 0.439 0.561
C81.2 Mixed cellularity
0.000 0.440 0.560
E06.9 Thyroiditis, unspecified
0.000 0.442 0.558
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.000 0.449 0.551
C95 Leukaemia of unspecified cell type
0.000 0.457 0.542
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.473 0.526
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.000 0.485 0.515
C81.3 Lymphocytic depletion
0.000 0.485 0.515
E06.1 Subacute thyroiditis
0.000 0.485 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
C86.5 Angioimmunoblastic T-cell lymphoma
0.000 0.487 0.513
C84.4 Peripheral T-cell lymphoma
0.000 0.488 0.512
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.000 0.497 0.502
C86.4 Blastic NK-cell lymphoma
0.000 0.497 0.502
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.000 0.497 0.502
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.000 0.497 0.502
C86.1 Hepatosplenic T-cell lymphoma
0.000 0.497 0.502
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.000 0.497 0.502
E12.9 Without complications
0.000 0.499 0.501
E12.8 With unspecified complications
0.000 0.499 0.501
E12.7 With multiple complications
0.000 0.499 0.501
E12.6 With other specified complications
0.000 0.499 0.501
E12.5 With peripheral circulatory complications
0.000 0.499 0.501
E12.4 With neurological complications
0.000 0.499 0.501
E12.3 With ophthalmic complications
0.000 0.499 0.501
E12.2 With renal complications
0.000 0.499 0.501
E12.1 With ketoacidosis
0.000 0.499 0.501
E12.0 With coma
0.000 0.499 0.501
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.505 0.495
C96.8 Histiocytic sarcoma
0.000 0.505 0.495
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.505 0.495
C96.6 Unifocal Langerhans-cell histiocytosis
0.000 0.505 0.495
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.000 0.505 0.495
C96.4 Sarcoma of dendritic cells (accessory cells)
0.000 0.505 0.495
C96.3 True histiocytic lymphoma
0.000 0.505 0.495
C96.2 Malignant mast cell tumour
0.000 0.505 0.495
C96.1 Malignant histiocytosis
0.000 0.505 0.495
C96.0 Letterer-Siwe disease
0.000 0.505 0.495
C81.7 Other Hodgkin's disease
0.000 0.512 0.488
C88.9 Malignant immunoproliferative disease, unspecified
0.000 0.513 0.487
C88.7 Other malignant immunoproliferative diseases
0.000 0.513 0.487
C88.3 Immunoproliferative small intestinal disease
0.000 0.513 0.487
C88.2 Gamma heavy chain disease
0.000 0.513 0.487
C88.1 Alpha heavy chain disease
0.000 0.513 0.487
E15 Nondiabetic hypoglycaemic coma
0.000 0.523 0.477
C91.9 Lymphoid leukaemia, unspecified
0.000 0.527 0.473
E13.3 With ophthalmic complications
0.000 0.530 0.470
C85.7 Other specified types of non-Hodgkin's lymphoma
0.000 0.535 0.465
E16 Other disorders of pancreatic internal secretion
0.000 0.541 0.459
C94.7 Other specified leukaemias
0.000 0.543 0.456
C94.5 Acute myelofibrosis
0.000 0.543 0.456
C94.4 Acute panmyelosis
0.000 0.543 0.456
C94.3 Mast cell leukaemia
0.000 0.543 0.456
C94.2 Acute megakaryoblastic leukaemia
0.000 0.543 0.456
C94.1 Chronic erythraemia
0.000 0.543 0.456
C94.0 Acute erythraemia and erythroleukaemia
0.000 0.543 0.456
E13.8 With unspecified complications
0.000 0.544 0.455
E13.7 With multiple complications
0.000 0.544 0.455
E13.6 With other specified complications
0.000 0.544 0.455
E13.5 With peripheral circulatory complications
0.000 0.544 0.455
E13.4 With neurological complications
0.000 0.544 0.455
E13.2 With renal complications
0.000 0.544 0.455
E13.1 With ketoacidosis
0.000 0.544 0.455
E13.0 With coma
0.000 0.544 0.455
C81.1 Nodular sclerosis
0.000 0.561 0.439
C91.5 Adult T-cell leukaemia
0.000 0.562 0.438
C81.0 Lymphocytic predominance
0.000 0.576 0.424
C93.9 Monocytic leukaemia, unspecified
0.000 0.583 0.416
C93.7 Other monocytic leukaemia
0.000 0.583 0.416
C93.3 Juvenile myelomonocytic leukaemia
0.000 0.583 0.416
C93.2 Subacute monocytic leukaemia
0.000 0.583 0.416
C93.0 Acute monocytic leukaemia
0.000 0.583 0.416
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.586 0.413
E45 Retarded development following protein-energy malnutrition
0.000 0.586 0.413
E43 Unspecified severe protein-energy malnutrition
0.000 0.586 0.413
E42 Marasmic kwashiorkor
0.000 0.586 0.413
E41 Nutritional marasmus
0.000 0.586 0.413
E40 Kwashiorkor
0.000 0.586 0.413
C95.9 Leukaemia, unspecified
0.000 0.590 0.410
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.000 0.597 0.402
C91.8 Mature B-cell leukaemia Burkitt-type
0.000 0.597 0.402
C91.7 Other lymphoid leukaemia
0.000 0.597 0.402
C91.6 Prolymphocytic leukaemia of T-cell type
0.000 0.597 0.402
C91.3 Prolymphocytic leukaemia
0.000 0.597 0.402
C91.2 Subacute lymphocytic leukaemia
0.000 0.597 0.402
C95.7 Other leukaemia of unspecified cell type
0.000 0.611 0.389
C95.2 Subacute leukaemia of unspecified cell type
0.000 0.611 0.389
E16.1 Other hypoglycaemia
0.000 0.618 0.382
C88.0 Waldenstrom's macroglobulinaemia
0.000 0.625 0.375
E13.9 Without complications
0.000 0.630 0.370
K90 Intestinal malabsorption
0.000 0.633 0.367
E50-E64 Other nutritional deficiencies
0.000 0.638 0.362
C91.0 Acute lymphoblastic leukaemia
0.000 0.640 0.360
E14.9 Without complications
0.000 0.658 0.342
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.671 0.329
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.671 0.329
E16.4 Abnormal secretion of gastrin
0.000 0.671 0.329
E16.3 Increased secretion of glucagon
0.000 0.671 0.329
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.671 0.329
C91.1 Chronic lymphocytic leukaemia
0.000 0.675 0.325
C95.1 Chronic leukaemia of unspecified cell type
0.001 0.681 0.319
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.001 0.690 0.309
C92 Myeloid leukaemia
0.000 0.691 0.309
C93.1 Chronic monocytic leukaemia
0.001 0.692 0.307
E46 Unspecified protein-energy malnutrition
0.000 0.693 0.307
C95.0 Acute leukaemia of unspecified cell type
0.001 0.696 0.303
E44.1 Mild protein-energy malnutrition
0.000 0.703 0.296
E44.0 Moderate protein-energy malnutrition
0.000 0.703 0.296
K90.9 Intestinal malabsorption, unspecified
0.000 0.716 0.284
E58 Dietary calcium deficiency
0.000 0.716 0.284
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.002 0.734 0.264
K90.3 Pancreatic steatorrhoea
0.000 0.736 0.263
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.736 0.263
K90.1 Tropical sprue
0.000 0.736 0.263
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.739 0.261
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.740 0.260
E63 Other nutritional deficiencies
0.000 0.740 0.260
E50 Vitamin A deficiency
0.000 0.740 0.260
E60 Dietary zinc deficiency
0.000 0.740 0.260
E59 Dietary selenium deficiency
0.000 0.740 0.260
E52 Niacin deficiency [pellagra]
0.000 0.740 0.260
C92.1 Chronic myeloid leukaemia
0.000 0.748 0.252
E54 Ascorbic acid deficiency
0.000 0.749 0.251
E65-E68 Obesity and other hyperalimentation
0.000 0.752 0.248
E51 Thiamine deficiency
0.000 0.753 0.247
E56 Other vitamin deficiencies
0.000 0.757 0.243
C90 Multiple myeloma and malignant plasma cell neoplasms
0.001 0.757 0.242
E61 Deficiency of other nutrient elements
0.000 0.762 0.238
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.000 0.778 0.222
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.000 0.778 0.222
C92.3 Myeloid sarcoma
0.000 0.778 0.222
C92.2 Subacute myeloid leukaemia
0.000 0.778 0.222
C92.5 Acute myelomonocytic leukaemia
0.000 0.786 0.214
E16.2 Hypoglycaemia, unspecified
0.000 0.789 0.211
C91.4 Hairy-cell leukaemia
0.001 0.791 0.209
E55 Vitamin D deficiency
0.000 0.791 0.209
K90.8 Other intestinal malabsorption
0.000 0.800 0.199
J45 Asthma
0.000 0.807 0.193
C92.7 Other myeloid leukaemia
0.000 0.810 0.189
E50.9 Vitamin A deficiency, unspecified
0.000 0.813 0.186
E50.8 Other manifestations of vitamin A deficiency
0.000 0.813 0.186
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.813 0.186
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.813 0.186
E50.5 Vitamin A deficiency with night blindness
0.000 0.813 0.186
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.813 0.186
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.813 0.186
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.813 0.186
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.813 0.186
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.813 0.186
E63.9 Nutritional deficiency, unspecified
0.000 0.813 0.186
E63.8 Other specified nutritional deficiencies
0.000 0.813 0.186
E63.1 Imbalance of constituents of food intake
0.000 0.813 0.186
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.813 0.186
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.813 0.186
E64.8 Sequelae of other nutritional deficiencies
0.000 0.813 0.186
E64.3 Sequelae of rickets
0.000 0.813 0.186
E64.2 Sequelae of vitamin C deficiency
0.000 0.813 0.186
E64.1 Sequelae of vitamin A deficiency
0.000 0.813 0.186
E64.0 Sequelae of protein-energy malnutrition
0.000 0.813 0.186
C92.9 Myeloid leukaemia, unspecified
0.000 0.817 0.183
E67 Other hyperalimentation
0.001 0.822 0.178
E68 Sequelae of hyperalimentation
0.001 0.822 0.178
E51.9 Thiamine deficiency, unspecified
0.000 0.823 0.177
E51.8 Other manifestations of thiamine deficiency
0.000 0.823 0.177
E51.1 Beriberi
0.000 0.823 0.177
C92.4 Acute promyelocytic leukaemia
0.000 0.824 0.176
C90.3 Solitary plasmacytoma
0.001 0.824 0.176
E61.2 Magnesium deficiency
0.000 0.825 0.174
E56.9 Vitamin deficiency, unspecified
0.000 0.826 0.174
E56.8 Deficiency of other vitamins
0.000 0.826 0.174
E56.0 Deficiency of vitamin E
0.000 0.826 0.174
E61.9 Deficiency of nutrient element, unspecified
0.000 0.829 0.171
E61.8 Deficiency of other specified nutrient elements
0.000 0.829 0.171
E61.7 Deficiency of multiple nutrient elements
0.000 0.829 0.171
E61.6 Vanadium deficiency
0.000 0.829 0.171
E61.5 Molybdenum deficiency
0.000 0.829 0.171
E61.4 Chromium deficiency
0.000 0.829 0.171
E61.3 Manganese deficiency
0.000 0.829 0.171
E61.0 Copper deficiency
0.000 0.829 0.171
E20-E35 Disorders of other endocrine glands
0.000 0.829 0.171
C90.1 Plasma cell leukaemia
0.001 0.829 0.170
C83.0 Small cell (diffuse)
0.004 0.831 0.165
E83 Disorders of mineral metabolism
0.160 0.835 0.005
E51.2 Wernicke's encephalopathy
0.000 0.835 0.164
E56.1 Deficiency of vitamin K
0.000 0.843 0.157
E24 Cushing's syndrome
0.000 0.848 0.152
E55.0 Rickets, active
0.000 0.850 0.150
E28 Ovarian dysfunction
0.000 0.851 0.149
E53 Deficiency of other B group vitamins
0.000 0.853 0.147
E61.1 Iron deficiency
0.000 0.855 0.145
J45.8 Mixed asthma
0.000 0.862 0.138
J45.1 Nonallergic asthma
0.000 0.863 0.137
E29 Testicular dysfunction
0.000 0.868 0.131
E24.2 Drug-induced Cushing's syndrome
0.000 0.870 0.130
E28.3 Primary ovarian failure
0.000 0.870 0.129
E83.9 Disorder of mineral metabolism, unspecified
0.125 0.872 0.003
E67.8 Other specified hyperalimentation
0.000 0.872 0.128
E67.3 Hypervitaminosis D
0.000 0.872 0.128
E67.2 Megavitamin-B6 syndrome
0.000 0.872 0.128
E67.1 Hypercarotenaemia
0.000 0.872 0.128
E67.0 Hypervitaminosis A
0.000 0.872 0.128
E24.9 Cushing's syndrome, unspecified
0.000 0.873 0.127
E25 Adrenogenital disorders
0.000 0.875 0.124
E83.3 Disorders of phosphorus metabolism
0.121 0.877 0.002
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.877 0.122
E32 Diseases of thymus
0.000 0.877 0.122
E31 Polyglandular dysfunction
0.000 0.877 0.122
E30 Disorders of puberty, not elsewhere classified
0.000 0.877 0.122
E83.8 Other disorders of mineral metabolism
0.115 0.882 0.004
E83.2 Disorders of zinc metabolism
0.115 0.882 0.004
E83.0 Disorders of copper metabolism
0.115 0.882 0.004
E28.2 Polycystic ovarian syndrome
0.000 0.883 0.117
E04 Other non-toxic goitre
0.000 0.885 0.115
E24.0 Pituitary-dependent Cushing's disease
0.000 0.888 0.112
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.891 0.109
E24.3 Ectopic ACTH syndrome
0.000 0.891 0.109
E24.1 Nelson's syndrome
0.000 0.891 0.109
E28.9 Ovarian dysfunction, unspecified
0.000 0.893 0.107
E28.8 Other ovarian dysfunction
0.000 0.893 0.107
E28.1 Androgen excess
0.000 0.893 0.107
E28.0 Oestrogen excess
0.000 0.893 0.107
E23 Hypofunction and other disorders of pituitary gland
0.000 0.894 0.106
E53.1 Pyridoxine deficiency
0.000 0.894 0.105
E53.0 Riboflavin deficiency
0.000 0.894 0.105
E29.1 Testicular hypofunction
0.000 0.897 0.103
K60.2 Anal fissure, unspecified
0.000 0.899 0.101
E26 Hyperaldosteronism
0.000 0.899 0.100
E24.8 Other Cushing's syndrome
0.000 0.899 0.100
E55.9 Vitamin D deficiency, unspecified
0.000 0.901 0.099
E53.9 Vitamin B deficiency, unspecified
0.000 0.903 0.097
E29.9 Testicular dysfunction, unspecified
0.000 0.905 0.094
E29.8 Other testicular dysfunction
0.000 0.905 0.094
E29.0 Testicular hyperfunction
0.000 0.905 0.094
E65 Localised adiposity
0.001 0.907 0.093
C92.0 Acute myeloid leukaemia
0.000 0.908 0.091
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.908 0.091
E25.9 Adrenogenital disorder, unspecified
0.000 0.910 0.089
E25.8 Other adrenogenital disorders
0.000 0.910 0.089
E23.2 Diabetes insipidus
0.000 0.911 0.089
E30.9 Disorder of puberty, unspecified
0.000 0.912 0.088
E30.8 Other disorders of puberty
0.000 0.912 0.088
E30.1 Precocious puberty
0.000 0.912 0.088
E30.0 Delayed puberty
0.000 0.912 0.088
E31.9 Polyglandular dysfunction, unspecified
0.000 0.912 0.088
E31.8 Other polyglandular dysfunction
0.000 0.912 0.088
E31.1 Polyglandular hyperfunction
0.000 0.912 0.088
E31.0 Autoimmune polyglandular failure
0.000 0.912 0.088
E32.9 Disease of thymus, unspecified
0.000 0.912 0.088
E32.8 Other diseases of thymus
0.000 0.912 0.088
E32.1 Abscess of thymus
0.000 0.912 0.088
E32.0 Persistent hyperplasia of thymus
0.000 0.912 0.088
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.912 0.088
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.912 0.088
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.912 0.088
E20 Hypoparathyroidism
0.001 0.916 0.084
C90.2 Plasmacytoma, extramedullary
0.001 0.916 0.082
E04.8 Other specified non-toxic goitre
0.000 0.917 0.083
E22 Hyperfunction of pituitary gland
0.000 0.917 0.082
E83.5 Disorders of calcium metabolism
0.081 0.919 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.924 0.076
E23.1 Drug-induced hypopituitarism
0.000 0.924 0.076
E23.6 Other disorders of pituitary gland
0.000 0.924 0.076
K60 Fissure and fistula of anal and rectal regions
0.000 0.925 0.075
E26.8 Other hyperaldosteronism
0.000 0.928 0.072
E26.1 Secondary hyperaldosteronism
0.000 0.928 0.072
E26.9 Hyperaldosteronism, unspecified
0.000 0.928 0.072
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.931 0.069
E04.0 Non-toxic diffuse goitre
0.000 0.933 0.067
K60.5 Anorectal fistula
0.000 0.934 0.066
F20.9 Schizophrenia, unspecified
0.065 0.935 0.000
K60.0 Acute anal fissure
0.000 0.935 0.065
K60.4 Rectal fistula
0.000 0.935 0.064
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.936 0.064
E23.7 Disorder of pituitary gland, unspecified
0.000 0.937 0.063
E34 Other endocrine disorders
0.001 0.938 0.061
E20.8 Other hypoparathyroidism
0.001 0.939 0.060
E20.0 Idiopathic hypoparathyroidism
0.001 0.939 0.060
E22.8 Other hyperfunction of pituitary gland
0.000 0.940 0.059
F20 Schizophrenia
0.058 0.942 0.000
E78.5 Hyperlipidaemia, unspecified
0.000 0.943 0.057
E20.1 Pseudohypoparathyroidism
0.001 0.943 0.056
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.945 0.055
E23.0 Hypopituitarism
0.000 0.947 0.053
G35 Multiple sclerosis
0.052 0.948 0.000
E26.0 Primary hyperaldosteronism
0.000 0.949 0.050
F20.0 Paranoid schizophrenia
0.049 0.951 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.952 0.048
E22.1 Hyperprolactinaemia
0.000 0.952 0.048
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.048 0.952 0.000
E27 Other disorders of adrenal gland
0.000 0.953 0.047
E04.2 Non-toxic multinodular goitre
0.000 0.953 0.047
E04.9 Non-toxic goitre, unspecified
0.000 0.954 0.046
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.954 0.046
E21.4 Other specified disorders of parathyroid gland
0.000 0.954 0.046
E21.2 Other hyperparathyroidism
0.000 0.955 0.045
F22 Persistent delusional disorders
0.045 0.955 0.000
E34.5 Androgen resistance syndrome
0.001 0.956 0.044
E34.4 Constitutional tall stature
0.001 0.956 0.044
E34.3 Short stature, not elsewhere classified
0.001 0.956 0.044
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.956 0.044
E34.1 Other hypersecretion of intestinal hormones
0.001 0.956 0.044
F20.2 Catatonic schizophrenia
0.044 0.956 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.044 0.956 0.000
F60-F69 Disorders of adult personality and behaviour
0.044 0.956 0.000
E34.8 Other specified endocrine disorders
0.001 0.957 0.043
F20.5 Residual schizophrenia
0.043 0.957 0.000
Chapter V Mental and behavioural disorders
0.043 0.957 0.000
F22.0 Delusional disorder
0.043 0.957 0.000
K60.1 Chronic anal fissure
0.000 0.957 0.043
F60 Specific personality disorders
0.042 0.958 0.000
F20.8 Other schizophrenia
0.042 0.958 0.000
F20.6 Simple schizophrenia
0.042 0.958 0.000
F20.4 Postschizophrenic depression
0.042 0.958 0.000
F20.3 Undifferentiated schizophrenia
0.042 0.958 0.000
F20.1 Hebephrenic schizophrenia
0.042 0.958 0.000
F60.3 Emotionally unstable personality disorder
0.042 0.958 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.958 0.042
E70-E90 Metabolic disorders
0.005 0.959 0.036
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.040 0.960 0.000
J45.0 Predominantly allergic asthma
0.000 0.960 0.040
F12 Mental and behavioural disorders due to use of cannabinoids
0.039 0.961 0.000
K60.3 Anal fistula
0.000 0.961 0.039
F11 Mental and behavioural disorders due to use of opioids
0.039 0.961 0.000
F69 Unspecified disorder of adult personality and behaviour
0.038 0.962 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.037 0.963 0.000
F12.1 Harmful use
0.036 0.964 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.964 0.036
M45-M49 Spondylopathies
0.000 0.965 0.035
F19.1 Harmful use
0.035 0.965 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.035 0.965 0.000
F60.9 Personality disorder, unspecified
0.035 0.965 0.000
F28 Other nonorganic psychotic disorders
0.034 0.966 0.000
F24 Induced delusional disorder
0.034 0.966 0.000
F21 Schizotypal disorder
0.034 0.966 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.966 0.034
E27.0 Other adrenocortical overactivity
0.000 0.966 0.034
E73 Lactose intolerance
0.002 0.966 0.031
F60.0 Paranoid personality disorder
0.033 0.967 0.000
F70-F79 Mental retardation
0.033 0.967 0.000
F64 Gender identity disorders
0.033 0.967 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.967 0.033
F15.1 Harmful use
0.033 0.967 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.033 0.967 0.000
F11.2 Dependence syndrome
0.033 0.967 0.000
F22.9 Persistent delusional disorder, unspecified
0.033 0.967 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.032 0.967 0.000
F22.8 Other persistent delusional disorders
0.032 0.968 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.032 0.968 0.000
E20.9 Hypoparathyroidism, unspecified
0.001 0.968 0.031
F19.2 Dependence syndrome
0.032 0.968 0.000
F80-F89 Disorders of psychological development
0.032 0.968 0.000
G37 Other demyelinating diseases of central nervous system
0.032 0.968 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.031 0.968 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.031 0.968 0.000
F23 Acute and transient psychotic disorders
0.031 0.968 0.000
F66 Psychological and behavioural disorders associated with sexual development and orientation
0.031 0.969 0.000
F65 Disorders of sexual preference
0.031 0.969 0.000
F63 Habit and impulse disorders
0.031 0.969 0.000
F61 Mixed and other personality disorders
0.031 0.969 0.000
F11.3 Withdrawal state
0.031 0.969 0.000
F60.7 Dependent personality disorder
0.031 0.969 0.000
F03 Unspecified dementia
0.031 0.969 0.000
F19.3 Withdrawal state
0.031 0.969 0.000
F60.2 Dissocial personality disorder
0.031 0.969 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.031 0.969 0.000
F12.5 Psychotic disorder
0.031 0.969 0.000
F62 Enduring personality changes, not attributable to brain damage and disease
0.031 0.969 0.000
F12.0 Acute intoxication
0.031 0.969 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.031 0.969 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.969 0.030
F68 Other disorders of adult personality and behaviour
0.030 0.969 0.000
F60.4 Histrionic personality disorder
0.030 0.969 0.000
F60.1 Schizoid personality disorder
0.030 0.969 0.000
E70 Disorders of aromatic amino-acid metabolism
0.003 0.969 0.027
G37.9 Demyelinating disease of central nervous system, unspecified
0.030 0.970 0.000
E83.4 Disorders of magnesium metabolism
0.026 0.970 0.004
F14 Mental and behavioural disorders due to use of cocaine
0.030 0.970 0.000
F60.6 Anxious [avoidant] personality disorder
0.030 0.970 0.000
E84 Cystic fibrosis
0.003 0.970 0.026

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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