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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2516685
log Bayes Factor = 33.7074
Chromosome 6   position 30,361,608  (GRCh37) Explore rs2516685 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.014 0.986
E10 Insulin-dependent diabetes mellitus
0.000 0.014 0.986
E10.9 Without complications
0.000 0.015 0.985
E00-E07 Disorders of thyroid gland
0.000 0.025 0.975
E10-E14 Diabetes mellitus
0.000 0.028 0.972
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.031 0.969
E10.3 With ophthalmic complications
0.000 0.038 0.962
E10.2 With renal complications
0.000 0.039 0.961
K90 Intestinal malabsorption
0.000 0.088 0.912
E06 Thyroiditis
0.000 0.103 0.897
E10.4 With neurological complications
0.000 0.145 0.855
K90.9 Intestinal malabsorption, unspecified
0.000 0.148 0.852
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.150 0.850
E20-E35 Disorders of other endocrine glands
0.000 0.155 0.845
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.212 0.788
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.212 0.788
E22 Hyperfunction of pituitary gland
0.000 0.221 0.779
E06.3 Autoimmune thyroiditis
0.000 0.221 0.779
E06.9 Thyroiditis, unspecified
0.000 0.234 0.766
E16 Other disorders of pancreatic internal secretion
0.000 0.235 0.765
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.241 0.759
E50-E64 Other nutritional deficiencies
0.000 0.250 0.750
E23 Hypofunction and other disorders of pituitary gland
0.000 0.254 0.746
K90.8 Other intestinal malabsorption
0.000 0.254 0.746
E14 Unspecified diabetes mellitus
0.000 0.256 0.744
E03.8 Other specified hypothyroidism
0.000 0.256 0.744
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.284 0.716
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.285 0.715
E27 Other disorders of adrenal gland
0.000 0.287 0.713
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.288 0.712
E03.5 Myxoedema coma
0.000 0.293 0.707
E03.4 Atrophy of thyroid (acquired)
0.000 0.293 0.707
E03.3 Postinfectious hypothyroidism
0.000 0.293 0.707
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.294 0.706
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.301 0.699
E00 Congenital iodine-deficiency syndrome
0.000 0.301 0.699
E12 Malnutrition-related diabetes mellitus
0.000 0.303 0.697
E10.7 With multiple complications
0.000 0.311 0.689
E22.1 Hyperprolactinaemia
0.000 0.317 0.683
E13 Other specified diabetes mellitus
0.000 0.320 0.680
E23.2 Diabetes insipidus
0.000 0.326 0.674
E55 Vitamin D deficiency
0.000 0.330 0.669
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.337 0.663
E06.1 Subacute thyroiditis
0.000 0.339 0.661
E21.0 Primary hyperparathyroidism
0.000 0.342 0.658
K90.3 Pancreatic steatorrhoea
0.000 0.346 0.654
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.346 0.654
K90.1 Tropical sprue
0.000 0.346 0.654
E03.1 Congenital hypothyroidism without goitre
0.000 0.347 0.653
E27.1 Primary adrenocortical insufficiency
0.000 0.348 0.652
E06.5 Other chronic thyroiditis
0.000 0.357 0.643
E06.4 Drug-induced thyroiditis
0.000 0.357 0.643
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.357 0.643
E06.0 Acute thyroiditis
0.000 0.357 0.643
E05.9 Thyrotoxicosis, unspecified
0.000 0.365 0.635
E14.1 With ketoacidosis
0.000 0.369 0.631
E16.1 Other hypoglycaemia
0.000 0.385 0.614
E55.9 Vitamin D deficiency, unspecified
0.000 0.388 0.612
E15 Nondiabetic hypoglycaemic coma
0.000 0.390 0.610
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.394 0.606
E32 Diseases of thymus
0.000 0.394 0.606
E31 Polyglandular dysfunction
0.000 0.394 0.606
E30 Disorders of puberty, not elsewhere classified
0.000 0.394 0.606
E24 Cushing's syndrome
0.000 0.395 0.605
E10.0 With coma
0.000 0.398 0.602
E14.2 Withrenal complications
0.000 0.399 0.601
E23.0 Hypopituitarism
0.000 0.404 0.596
E14.8 With unspecified complications
0.000 0.407 0.593
E10.1 With ketoacidosis
0.000 0.408 0.592
E58 Dietary calcium deficiency
0.000 0.410 0.590
E26 Hyperaldosteronism
0.000 0.416 0.584
E27.2 Addisonian crisis
0.000 0.425 0.575
E51 Thiamine deficiency
0.000 0.426 0.574
E14.4 With neurological complications
0.000 0.429 0.571
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.431 0.569
E14.6 With other specified complications
0.000 0.433 0.567
E10.6 With other specified complications
0.000 0.433 0.566
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.441 0.559
E22.8 Other hyperfunction of pituitary gland
0.000 0.441 0.559
E23.7 Disorder of pituitary gland, unspecified
0.000 0.444 0.556
E10.8 With unspecified complications
0.000 0.445 0.555
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.450 0.550
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.451 0.548
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.451 0.548
E16.4 Abnormal secretion of gastrin
0.000 0.451 0.548
E16.3 Increased secretion of glucagon
0.000 0.451 0.548
E14.3 With ophthalmic complications
0.000 0.460 0.540
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.461 0.539
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.462 0.537
E63 Other nutritional deficiencies
0.000 0.462 0.537
E50 Vitamin A deficiency
0.000 0.462 0.537
E60 Dietary zinc deficiency
0.000 0.462 0.537
E59 Dietary selenium deficiency
0.000 0.462 0.537
E52 Niacin deficiency [pellagra]
0.000 0.462 0.537
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.465 0.535
E23.1 Drug-induced hypopituitarism
0.000 0.465 0.535
E40-E46 Malnutrition
0.000 0.465 0.534
E25 Adrenogenital disorders
0.000 0.465 0.534
E14.7 With multiple complications
0.000 0.466 0.533
E14.0 With coma
0.000 0.466 0.533
E10.5 With peripheral circulatory complications
0.000 0.473 0.526
E20 Hypoparathyroidism
0.000 0.475 0.524
E54 Ascorbic acid deficiency
0.000 0.485 0.515
E13.3 With ophthalmic complications
0.000 0.486 0.514
E27.5 Adrenomedullary hyperfunction
0.000 0.489 0.511
E27.0 Other adrenocortical overactivity
0.000 0.489 0.511
E05.5 Thyroid crisis or storm
0.000 0.489 0.511
E05.4 Thyrotoxicosis factitia
0.000 0.489 0.511
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.489 0.511
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.489 0.511
E56 Other vitamin deficiencies
0.000 0.492 0.508
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.499 0.501
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.499 0.501
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.499 0.501
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.499 0.501
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.499 0.501
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.499 0.501
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.499 0.501
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.499 0.501
E12.9 Without complications
0.000 0.500 0.500
E12.8 With unspecified complications
0.000 0.500 0.500
E12.7 With multiple complications
0.000 0.500 0.500
E12.6 With other specified complications
0.000 0.500 0.500
E12.5 With peripheral circulatory complications
0.000 0.500 0.500
E12.4 With neurological complications
0.000 0.500 0.500
E12.3 With ophthalmic complications
0.000 0.500 0.500
E12.2 With renal complications
0.000 0.500 0.500
E12.1 With ketoacidosis
0.000 0.500 0.500
E12.0 With coma
0.000 0.500 0.500
E21.2 Other hyperparathyroidism
0.000 0.503 0.497
E27.9 Disorder of adrenal gland, unspecified
0.000 0.506 0.494
E13.8 With unspecified complications
0.000 0.512 0.488
E13.7 With multiple complications
0.000 0.512 0.488
E13.6 With other specified complications
0.000 0.512 0.488
E13.5 With peripheral circulatory complications
0.000 0.512 0.488
E13.4 With neurological complications
0.000 0.512 0.488
E13.2 With renal complications
0.000 0.512 0.488
E13.1 With ketoacidosis
0.000 0.512 0.488
E13.0 With coma
0.000 0.512 0.488
E28 Ovarian dysfunction
0.000 0.518 0.482
E55.0 Rickets, active
0.000 0.520 0.480
E14.5 With peripheral circulatory complications
0.000 0.534 0.466
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.535 0.465
E21.4 Other specified disorders of parathyroid gland
0.000 0.536 0.464
E24.8 Other Cushing's syndrome
0.000 0.549 0.451
E51.2 Wernicke's encephalopathy
0.000 0.552 0.448
E16.2 Hypoglycaemia, unspecified
0.000 0.559 0.441
E13.9 Without complications
0.000 0.562 0.438
E24.0 Pituitary-dependent Cushing's disease
0.000 0.563 0.437
E05.8 Other thyrotoxicosis
0.000 0.564 0.435
E30.9 Disorder of puberty, unspecified
0.000 0.565 0.434
E30.8 Other disorders of puberty
0.000 0.565 0.434
E30.1 Precocious puberty
0.000 0.565 0.434
E30.0 Delayed puberty
0.000 0.565 0.434
E31.9 Polyglandular dysfunction, unspecified
0.000 0.565 0.434
E31.8 Other polyglandular dysfunction
0.000 0.565 0.434
E31.1 Polyglandular hyperfunction
0.000 0.565 0.434
E31.0 Autoimmune polyglandular failure
0.000 0.565 0.434
E32.9 Disease of thymus, unspecified
0.000 0.565 0.434
E32.8 Other diseases of thymus
0.000 0.565 0.434
E32.1 Abscess of thymus
0.000 0.565 0.434
E32.0 Persistent hyperplasia of thymus
0.000 0.565 0.434
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.565 0.434
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.565 0.434
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.565 0.434
E29 Testicular dysfunction
0.000 0.566 0.434
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.566 0.434
E24.3 Ectopic ACTH syndrome
0.000 0.566 0.434
E24.1 Nelson's syndrome
0.000 0.566 0.434
E24.9 Cushing's syndrome, unspecified
0.000 0.567 0.433
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.572 0.428
E61 Deficiency of other nutrient elements
0.000 0.572 0.428
E26.9 Hyperaldosteronism, unspecified
0.000 0.576 0.423
E23.6 Other disorders of pituitary gland
0.000 0.578 0.422
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.580 0.420
E26.8 Other hyperaldosteronism
0.000 0.581 0.419
E26.1 Secondary hyperaldosteronism
0.000 0.581 0.419
E24.2 Drug-induced Cushing's syndrome
0.000 0.587 0.413
E07 Other disorders of thyroid
0.000 0.588 0.412
E51.9 Thiamine deficiency, unspecified
0.000 0.588 0.411
E51.8 Other manifestations of thiamine deficiency
0.000 0.588 0.411
E51.1 Beriberi
0.000 0.588 0.411
E53 Deficiency of other B group vitamins
0.000 0.597 0.403
E22.0 Acromegaly and pituitary gigantism
0.000 0.601 0.399
E26.0 Primary hyperaldosteronism
0.000 0.609 0.391
E50.9 Vitamin A deficiency, unspecified
0.000 0.614 0.385
E50.8 Other manifestations of vitamin A deficiency
0.000 0.614 0.385
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.614 0.385
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.614 0.385
E50.5 Vitamin A deficiency with night blindness
0.000 0.614 0.385
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.614 0.385
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.614 0.385
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.614 0.385
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.614 0.385
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.614 0.385
E63.9 Nutritional deficiency, unspecified
0.000 0.614 0.385
E63.8 Other specified nutritional deficiencies
0.000 0.614 0.385
E63.1 Imbalance of constituents of food intake
0.000 0.614 0.385
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.614 0.385
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.614 0.385
E64.8 Sequelae of other nutritional deficiencies
0.000 0.614 0.385
E64.3 Sequelae of rickets
0.000 0.614 0.385
E64.2 Sequelae of vitamin C deficiency
0.000 0.614 0.385
E64.1 Sequelae of vitamin A deficiency
0.000 0.614 0.385
E64.0 Sequelae of protein-energy malnutrition
0.000 0.614 0.385
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.616 0.383
E45 Retarded development following protein-energy malnutrition
0.000 0.616 0.383
E43 Unspecified severe protein-energy malnutrition
0.000 0.616 0.383
E42 Marasmic kwashiorkor
0.000 0.616 0.383
E41 Nutritional marasmus
0.000 0.616 0.383
E40 Kwashiorkor
0.000 0.616 0.383
E25.9 Adrenogenital disorder, unspecified
0.000 0.617 0.383
E25.8 Other adrenogenital disorders
0.000 0.617 0.383
E20.8 Other hypoparathyroidism
0.000 0.624 0.376
E20.1 Pseudohypoparathyroidism
0.000 0.624 0.376
E20.0 Idiopathic hypoparathyroidism
0.000 0.624 0.376
E56.9 Vitamin deficiency, unspecified
0.000 0.636 0.364
E56.8 Deficiency of other vitamins
0.000 0.636 0.364
E56.0 Deficiency of vitamin E
0.000 0.636 0.364
E28.9 Ovarian dysfunction, unspecified
0.000 0.654 0.346
E28.8 Other ovarian dysfunction
0.000 0.654 0.346
E28.1 Androgen excess
0.000 0.654 0.346
E28.0 Oestrogen excess
0.000 0.654 0.346
E27.8 Other specified disorders of adrenal gland
0.000 0.662 0.338
E56.1 Deficiency of vitamin K
0.000 0.665 0.335
E21.3 Hyperparathyroidism, unspecified
0.000 0.676 0.324
E34 Other endocrine disorders
0.001 0.677 0.322
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.688 0.312
E29.8 Other testicular dysfunction
0.000 0.689 0.311
E29.0 Testicular hyperfunction
0.000 0.689 0.311
E61.9 Deficiency of nutrient element, unspecified
0.000 0.693 0.307
E61.8 Deficiency of other specified nutrient elements
0.000 0.693 0.307
E61.7 Deficiency of multiple nutrient elements
0.000 0.693 0.307
E61.6 Vanadium deficiency
0.000 0.693 0.307
E61.5 Molybdenum deficiency
0.000 0.693 0.307
E61.4 Chromium deficiency
0.000 0.693 0.307
E61.3 Manganese deficiency
0.000 0.693 0.307
E61.0 Copper deficiency
0.000 0.693 0.307
E29.9 Testicular dysfunction, unspecified
0.000 0.699 0.301
E28.3 Primary ovarian failure
0.000 0.701 0.299
E07.1 Dyshormogenetic goitre
0.000 0.704 0.295
E07.0 Hypersecretion of calcitonin
0.000 0.704 0.295
E20.9 Hypoparathyroidism, unspecified
0.000 0.705 0.295
E53.1 Pyridoxine deficiency
0.000 0.711 0.289
E53.0 Riboflavin deficiency
0.000 0.711 0.289
E61.2 Magnesium deficiency
0.000 0.711 0.289
E28.2 Polycystic ovarian syndrome
0.000 0.712 0.288
E44.1 Mild protein-energy malnutrition
0.000 0.725 0.275
E44.0 Moderate protein-energy malnutrition
0.000 0.725 0.275
E07.8 Other specified disorders of thyroid
0.000 0.731 0.269
E53.9 Vitamin B deficiency, unspecified
0.000 0.734 0.266
E34.5 Androgen resistance syndrome
0.001 0.768 0.231
E34.4 Constitutional tall stature
0.001 0.768 0.231
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.768 0.231
E34.1 Other hypersecretion of intestinal hormones
0.001 0.768 0.231
E61.1 Iron deficiency
0.000 0.773 0.227
E34.8 Other specified endocrine disorders
0.001 0.775 0.224
E46 Unspecified protein-energy malnutrition
0.000 0.777 0.223
E34.3 Short stature, not elsewhere classified
0.001 0.779 0.221
E65-E68 Obesity and other hyperalimentation
0.001 0.779 0.220
E53.8 Deficiency of other specified B group vitamins
0.000 0.805 0.195
E34.0 Carcinoid syndrome
0.001 0.811 0.188
E29.1 Testicular hypofunction
0.000 0.838 0.162
E67 Other hyperalimentation
0.001 0.841 0.158
E68 Sequelae of hyperalimentation
0.001 0.841 0.158
E04 Other non-toxic goitre
0.000 0.861 0.139
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.119 0.881 0.000
E67.8 Other specified hyperalimentation
0.001 0.886 0.113
E67.3 Hypervitaminosis D
0.001 0.886 0.113
E67.2 Megavitamin-B6 syndrome
0.001 0.886 0.113
E67.1 Hypercarotenaemia
0.001 0.886 0.113
E67.0 Hypervitaminosis A
0.001 0.886 0.113
E34.9 Endocrine disorder, unspecified
0.001 0.889 0.110
G25.8 Other specified extrapyramidal and movement disorders
0.105 0.895 0.000
E04.8 Other specified non-toxic goitre
0.000 0.900 0.099
E04.0 Non-toxic diffuse goitre
0.000 0.906 0.094
G25 Other extrapyramidal and movement disorders
0.094 0.906 0.000
G20-G26 Extrapyramidal and movement disorders
0.087 0.913 0.000
M35.0 Sicca syndrome [Sjogren]
0.000 0.913 0.087
G24 Dystonia
0.084 0.916 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.917 0.083
G21 Secondary Parkinsonism
0.079 0.921 0.000
G25.9 Extrapyramidal and movement disorder, unspecified
0.079 0.921 0.000
E04.2 Non-toxic multinodular goitre
0.000 0.923 0.077
G24.9 Dystonia, unspecified
0.076 0.924 0.000
G25.1 Drug-induced tremor
0.073 0.927 0.000
G25.5 Other chorea
0.072 0.928 0.000
G24.3 Spasmodic torticollis
0.072 0.928 0.000
G21.9 Secondary Parkinsonism, unspecified
0.069 0.931 0.000
G23 Other degenerative diseases of basal ganglia
0.069 0.931 0.000
G25.6 Drug-induced tics and other tics of organic origin
0.068 0.932 0.000
G25.4 Drug-induced chorea
0.068 0.932 0.000
G24.8 Other dystonia
0.067 0.933 0.000
G25.0 Essential tremor
0.065 0.935 0.000
G21.1 Other drug-induced secondary Parkinsonism
0.064 0.935 0.000
G24.1 Idiopathic familial dystonia
0.064 0.936 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.063 0.937 0.000
G22 Parkinsonism in diseases classified elsewhere
0.063 0.937 0.000
G24.0 Drug-induced dystonia
0.061 0.939 0.000
G24.4 Idiopathic orofacial dystonia
0.060 0.939 0.000
G24.2 Idiopathic nonfamilial dystonia
0.060 0.939 0.000
G21.4 Vascular parkinsonism
0.059 0.941 0.000
G24.5 Blepharospasm
0.058 0.942 0.000
G21.8 Other secondary Parkinsonism
0.057 0.943 0.000
G21.3 Postencephalitic Parkinsonism
0.057 0.943 0.000
G21.2 Secondary Parkinsonism due to other external agents
0.057 0.943 0.000
G21.0 Malignant neuroleptic syndrome
0.057 0.943 0.000
G20 Parkinson's disease
0.056 0.944 0.000
G25.3 Myoclonus
0.054 0.945 0.000
K90-K93 Other diseases of the digestive system
0.000 0.946 0.054
G23.8 Other specified degenerative diseases of basal ganglia
0.053 0.947 0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
0.052 0.948 0.000
G23.9 Degenerative disease of basal ganglia, unspecified
0.049 0.950 0.000
G23.3 Multiple system atrophy, cerebellar type
0.049 0.950 0.000
G23.2 Striatonigral degeneration
0.049 0.950 0.000
G23.0 Hallervorden-Spatz disease
0.049 0.950 0.000
E65 Localised adiposity
0.003 0.953 0.044
G25.2 Other specified forms of tremor
0.046 0.954 0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.043 0.957 0.000
E14.9 Without complications
0.000 0.959 0.041
E83 Disorders of mineral metabolism
0.027 0.960 0.013
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.961 0.039
K81.0 Acute cholecystitis
0.030 0.970 0.000
E66 Obesity
0.000 0.970 0.030
E83.8 Other disorders of mineral metabolism
0.019 0.971 0.010
E83.2 Disorders of zinc metabolism
0.019 0.971 0.010
E83.0 Disorders of copper metabolism
0.019 0.971 0.010
H26.9 Cataract, unspecified
0.000 0.971 0.029
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.972 0.028
K93.1 Megacolon in Chagas' disease
0.000 0.972 0.028
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.972 0.028
E83.9 Disorder of mineral metabolism, unspecified
0.019 0.972 0.010
E04.9 Non-toxic goitre, unspecified
0.000 0.974 0.026
E66.0 Obesity due to excess calories
0.000 0.977 0.022
E04.1 Non-toxic single thyroid nodule
0.000 0.978 0.022
E66.1 Drug-induced obesity
0.000 0.978 0.021
N05.9 Unspecified
0.000 0.980 0.020
E70-E90 Metabolic disorders
0.001 0.981 0.018
E83.3 Disorders of phosphorus metabolism
0.007 0.982 0.012
N05 Unspecified nephritic syndrome
0.000 0.982 0.018
E11 Non-insulin-dependent diabetes mellitus
0.000 0.982 0.018
N05.2 Diffuse membranous glomerulonephritis
0.000 0.984 0.016
N05.8 Other
0.000 0.984 0.016
M35 Other systemic involvement of connective tissue
0.000 0.984 0.016
E83.4 Disorders of magnesium metabolism
0.004 0.985 0.011
E86 Volume depletion
0.000 0.986 0.014
E11.6 With other specified complications
0.000 0.986 0.014
E70 Disorders of aromatic amino-acid metabolism
0.001 0.986 0.013
E77 Disorders of glycoprotein metabolism
0.001 0.986 0.013
E76 Disorders of glycosaminoglycan metabolism
0.001 0.986 0.013
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.986 0.013
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.986 0.013
N05.1 Focal and segmental glomerular lesions
0.000 0.986 0.014
E72 Other disorders of amino-acid metabolism
0.001 0.986 0.013
M35.2 Behcet's disease
0.000 0.986 0.014
N05.5 Diffuse mesangiocapillary glomerulonephritis
0.000 0.986 0.014
G57.6 Lesion of plantar nerve
0.014 0.986 0.000
E79 Disorders of purine and pyrimidine metabolism
0.001 0.986 0.013
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.986 0.013
E74 Other disorders of carbohydrate metabolism
0.001 0.987 0.013
I83 Varicose veins of lower extremities
0.013 0.987 0.000
E84 Cystic fibrosis
0.001 0.987 0.012
N05.6 Dense deposit disease
0.000 0.987 0.013
N05.4 Diffuse endocapillary proliferative glomerulonephritis
0.000 0.987 0.013
N05.0 Minor glomerular abnormality
0.000 0.987 0.013
E11.7 With multiple complications
0.000 0.987 0.013
E66.2 Extreme obesity with alveolar hypoventilation
0.001 0.987 0.012
N05.3 Diffuse mesangial proliferative glomerulonephritis
0.000 0.988 0.012
E11.1 With ketoacidosis
0.000 0.988 0.012
E73 Lactose intolerance
0.001 0.988 0.011
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.988 0.011
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.988 0.011
M35.5 Multifocal fibrosclerosis
0.000 0.988 0.011
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.988 0.011
M35.8 Other specified systemic involvement of connective tissue
0.000 0.989 0.011
G90.2 Horner's syndrome
0.000 0.989 0.011
N05.7 Diffuse crescentic glomerulonephritis
0.000 0.989 0.011
E11.0 With coma
0.000 0.989 0.011
K40 Inguinal hernia
0.011 0.989 0.000
G90.0 Idiopathic peripheral autonomic neuropathy
0.000 0.989 0.011
G90 Disorders of autonomic nervous system
0.000 0.989 0.011
E11.2 With renal complications
0.000 0.989 0.011
I83.0 Varicose veins of lower extremities with ulcer
0.010 0.990 0.000
E11.8 With unspecified complications
0.000 0.990 0.010
E70.3 Albinism
0.001 0.990 0.010
M35.1 Other overlap syndromes
0.000 0.990 0.010
G90.3 Multisystem degeneration
0.000 0.990 0.010
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.990 0.010
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.990 0.010
E70.2 Disorders of tyrosine metabolism
0.001 0.990 0.010
E70.1 Other hyperphenylalaninaemias
0.001 0.990 0.010
E70.0 Classical phenylketonuria
0.001 0.990 0.010
H26 Other cataract
0.000 0.990 0.010
E71.3 Disorders of fatty-acid metabolism
0.001 0.990 0.010
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.990 0.010
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.990 0.010
E71.0 Maple-syrup-urine disease
0.001 0.990 0.010
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.990 0.010
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.990 0.010
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.990 0.010
E76.2 Other mucopolysaccharidoses
0.001 0.990 0.010
E76.1 Mucopolysaccharidosis, type II
0.001 0.990 0.010
E76.0 Mucopolysaccharidosis, type I
0.001 0.990 0.010
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.990 0.010
E77.8 Other disorders of glycoprotein metabolism
0.001 0.990 0.010
E77.1 Defects in glycoprotein degradation
0.001 0.990 0.010
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.990 0.010
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.990 0.010
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.990 0.010
E72.5 Disorders of glycine metabolism
0.001 0.990 0.010
E72.4 Disorders of ornithine metabolism
0.001 0.990 0.010
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.990 0.010
E72.2 Disorders of urea cycle metabolism
0.001 0.990 0.010
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.990 0.010
E72.0 Disorders of amino-acid transport
0.001 0.990 0.009
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.990 0.009
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.990 0.009
E79.1 Lesch-Nyhan syndrome
0.001 0.990 0.009
E75.6 Lipid storage disorder, unspecified
0.001 0.990 0.009
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.990 0.009
E75.3 Sphingolipidosis, unspecified
0.001 0.990 0.009
E75.1 Other gangliosidosis
0.001 0.990 0.009
E75.0 GM2 gangliosidosis
0.001 0.990 0.009
E75.2 Other sphingolipidosis
0.001 0.990 0.009
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.990 0.009
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.990 0.009
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.990 0.009
E74.2 Disorders of galactose metabolism
0.001 0.990 0.009
E74.1 Disorders of fructose metabolism
0.001 0.990 0.009
E74.0 Glycogen storage disease
0.001 0.990 0.009
E85 Amyloidosis
0.001 0.990 0.009
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.990 0.009
E75.5 Other lipid storage disorders
0.001 0.990 0.009
E84.8 Cystic fibrosis with other manifestations
0.001 0.990 0.009
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.990 0.009
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.990 0.009
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.990 0.009
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.990 0.009
G90.9 Disorder of autonomic nervous system, unspecified
0.000 0.991 0.009
K40.0 Bilateral inguinal hernia, with obstruction, without gangrene
0.009 0.991 0.000
M35.7 Hypermobility syndrome
0.000 0.991 0.009
E84.9 Cystic fibrosis, unspecified
0.001 0.991 0.008
E66.8 Other obesity
0.000 0.991 0.009
X23.9 Unspecified place
0.000 0.991 0.009
E73.8 Other lactose intolerance
0.001 0.991 0.008
E73.1 Secondary lactase deficiency
0.001 0.991 0.008
E73.0 Congenital lactase deficiency
0.001 0.991 0.008
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.009 0.991 0.000
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.991 0.008
G90.8 Other disorders of autonomic nervous system
0.000 0.991 0.008
H26.3 Drug-induced cataract
0.000 0.992 0.008
K40.1 Bilateral inguinal hernia, with gangrene
0.008 0.992 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.992 0.008
G90.4 Autonomic dysreflexia
0.000 0.992 0.008
G90.1 Familial dysautonomia [Riley-Day]
0.000 0.992 0.008
H26.8 Other specified cataract
0.000 0.992 0.008
E89.3 Postprocedural hypopituitarism
0.000 0.992 0.008
H26.1 Traumatic cataract
0.000 0.992 0.008
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.992 0.007
K40.4 Unilateral or unspecified inguinal hernia, with gangrene
0.007 0.992 0.000
E88 Other metabolic disorders
0.001 0.992 0.006
I83.1 Varicose veins of lower extremities with inflammation
0.007 0.993 0.000
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.993 0.007
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.993 0.007
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.993 0.007
E85.3 Secondary systemic amyloidosis
0.001 0.993 0.007
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.993 0.007
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.993 0.007
E89.5 Postprocedural testicular hypofunction
0.000 0.993 0.007
E85.9 Amyloidosis, unspecified
0.001 0.993 0.007
G57 Mononeuropathies of lower limb
0.007 0.993 0.000
E85.8 Other amyloidosis
0.001 0.993 0.006
E73.9 Lactose intolerance, unspecified
0.001 0.993 0.006
E83.5 Disorders of calcium metabolism
0.003 0.993 0.004
H26.2 Complicated cataract
0.000 0.993 0.007
E89.2 Postprocedural hypoparathyroidism
0.000 0.993 0.007
E89.4 Postprocedural ovarian failure
0.000 0.993 0.006
E80.2 Other porphyria
0.001 0.993 0.006
E89.1 Postprocedural hypoinsulinaemia
0.000 0.993 0.006
G57.8 Other mononeuropathies of lower limb
0.006 0.994 0.000
X23 Contact with hornets, wasps and bees
0.000 0.994 0.006
M77.47 Metatarsalgia-Ankle/Foot
0.006 0.994 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.994 0.006
E80.5 Crigler-Najjar syndrome
0.001 0.994 0.006
E80.3 Defects of catalase and peroxydase
0.001 0.994 0.006
E80.0 Hereditary erythropoietic porphyria
0.001 0.994 0.006
E80.6 Other disorders of bilirubin metabolism
0.001 0.994 0.006
X23.0 Home
0.000 0.994 0.006
E88.8 Other specified metabolic disorders
0.001 0.994 0.005
E88.2 Lipomatosis, not elsewhere classified
0.001 0.994 0.005
H27 Other disorders of lens
0.000 0.994 0.006
E11.5 With peripheral circulatory complications
0.000 0.994 0.006
H27.0 Aphakia
0.000 0.994 0.006
H27.8 Other specified disorders of lens
0.000 0.994 0.006
E88.3 Tumour lysis syndrome
0.001 0.994 0.005
E88.9 Metabolic disorder, unspecified
0.001 0.995 0.005
G57.1 Meralgia paraesthetica
0.005 0.995 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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