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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517471
log Bayes Factor = 73.6748
Chromosome 6   position 31,052,098  (GRCh37) Explore rs2517471 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E10.9 Without complications
0.000 0.003 0.997
E10.3 With ophthalmic complications
0.000 0.006 0.994
D86 Sarcoidosis
0.000 0.010 0.990
D86.9 Sarcoidosis, unspecified
0.000 0.010 0.990
L40 Psoriasis
0.000 0.014 0.986
E00-E07 Disorders of thyroid gland
0.018 0.015 0.968
D80-D89 Certain disorders involving the immune mechanism
0.000 0.016 0.984
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.021 0.979
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.026 0.974
D70 Agranulocytosis
0.000 0.030 0.970
E05 Thyrotoxicosis [hyperthyroidism]
0.003 0.030 0.967
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.031 0.969
L40.5 Arthropathic psoriasis
0.000 0.031 0.969
D50-D53 Nutritional anaemias
0.000 0.055 0.945
E11 Non-insulin-dependent diabetes mellitus
0.000 0.057 0.943
L40.0 Psoriasis vulgaris
0.000 0.060 0.940
D51 Vitamin B12 deficiency anaemia
0.000 0.081 0.919
D86.1 Sarcoidosis of lymph nodes
0.000 0.087 0.913
E10.2 With renal complications
0.000 0.107 0.893
E10.8 With unspecified complications
0.000 0.107 0.893
E10.4 With neurological complications
0.000 0.120 0.880
E11.5 With peripheral circulatory complications
0.000 0.125 0.875
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.129 0.871
E10.5 With peripheral circulatory complications
0.000 0.134 0.866
D72 Other disorders of white blood cells
0.000 0.139 0.861
E50-E64 Other nutritional deficiencies
0.000 0.143 0.857
E11.3 With ophthalmic complications
0.000 0.144 0.856
E11.4 With neurological complications
0.000 0.152 0.848
E10.6 With other specified complications
0.000 0.157 0.843
D86.0 Sarcoidosis of lung
0.000 0.169 0.831
D80 Immunodeficiency with predominantly antibody defects
0.000 0.176 0.824
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.180 0.820
D53 Other nutritional anaemias
0.000 0.192 0.808
E55 Vitamin D deficiency
0.000 0.194 0.806
E10.0 With coma
0.000 0.203 0.797
D55-D59 Haemolytic anaemias
0.000 0.207 0.793
D72.8 Other specified disorders of white blood cells
0.000 0.212 0.788
D86.8 Sarcoidosis of other and combined sites
0.000 0.212 0.788
D75 Other diseases of blood and blood-forming organs
0.000 0.221 0.779
D83 Common variable immunodeficiency
0.000 0.223 0.777
E11.1 With ketoacidosis
0.000 0.227 0.773
E55.9 Vitamin D deficiency, unspecified
0.000 0.231 0.769
D86.3 Sarcoidosis of skin
0.000 0.234 0.766
E11.8 With unspecified complications
0.000 0.236 0.764
E03 Other hypothyroidism
0.402 0.238 0.361
L40.4 Guttate psoriasis
0.000 0.239 0.761
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.242 0.758
D59 Acquired haemolytic anaemia
0.000 0.255 0.745
L40.1 Generalised pustular psoriasis
0.000 0.265 0.735
E14 Unspecified diabetes mellitus
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
D53.9 Nutritional anaemia, unspecified
0.000 0.290 0.710
L40.3 Pustulosis palmaris et plantaris
0.000 0.293 0.707
L40.2 Acrodermatitis continua
0.000 0.293 0.707
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.013 0.293 0.694
E00 Congenital iodine-deficiency syndrome
0.013 0.293 0.694
D81 Combined immunodeficiencies
0.000 0.295 0.705
E13 Other specified diabetes mellitus
0.000 0.298 0.702
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.300 0.700
D74 Methaemoglobinaemia
0.000 0.302 0.698
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.302 0.698
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.302 0.698
E11.6 With other specified complications
0.000 0.303 0.697
E05.5 Thyroid crisis or storm
0.002 0.305 0.693
E05.4 Thyrotoxicosis factitia
0.002 0.305 0.693
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.002 0.305 0.693
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.002 0.305 0.693
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.312 0.688
E40-E46 Malnutrition
0.000 0.313 0.687
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.317 0.683
E02 Subclinical iodine-deficiency hypothyroidism
0.012 0.318 0.670
E16.1 Other hypoglycaemia
0.000 0.318 0.681
E11.7 With multiple complications
0.000 0.324 0.676
D50 Iron deficiency anaemia
0.000 0.324 0.676
D82 Immunodeficiency associated with other major defects
0.000 0.325 0.675
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.327 0.673
E06 Thyroiditis
0.009 0.330 0.660
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.334 0.666
E53 Deficiency of other B group vitamins
0.000 0.338 0.662
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.341 0.659
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.341 0.659
D51.2 Transcobalamin II deficiency
0.000 0.341 0.659
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.341 0.659
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.346 0.654
E05.8 Other thyrotoxicosis
0.002 0.346 0.651
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.349 0.650
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.353 0.647
D59.1 Other autoimmune haemolytic anaemias
0.000 0.355 0.645
E51 Thiamine deficiency
0.000 0.356 0.644
D83.9 Common variable immunodeficiency, unspecified
0.000 0.372 0.628
D72.9 Disorder of white blood cells, unspecified
0.000 0.382 0.618
D72.0 Genetic anomalies of leukocytes
0.000 0.382 0.618
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.386 0.614
E63 Other nutritional deficiencies
0.000 0.386 0.614
E50 Vitamin A deficiency
0.000 0.386 0.614
E60 Dietary zinc deficiency
0.000 0.386 0.614
E59 Dietary selenium deficiency
0.000 0.386 0.614
E52 Niacin deficiency [pellagra]
0.000 0.386 0.614
D75.0 Familial erythrocytosis
0.000 0.388 0.611
D84 Other immunodeficiencies
0.000 0.390 0.609
E14.3 With ophthalmic complications
0.000 0.395 0.605
D72.1 Eosinophilia
0.000 0.407 0.593
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.409 0.591
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.409 0.591
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.409 0.591
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.409 0.591
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.409 0.591
D50.9 Iron deficiency anaemia, unspecified
0.000 0.409 0.591
E54 Ascorbic acid deficiency
0.000 0.410 0.590
D53.8 Other specified nutritional anaemias
0.000 0.421 0.579
D53.2 Scorbutic anaemia
0.000 0.421 0.579
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.421 0.579
D53.0 Protein deficiency anaemia
0.000 0.421 0.579
E55.0 Rickets, active
0.000 0.422 0.578
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.429 0.571
E06.9 Thyroiditis, unspecified
0.004 0.430 0.566
E14.8 With unspecified complications
0.000 0.431 0.569
D66 Hereditary factor VIII deficiency
0.000 0.431 0.569
D55 Anaemia due to enzyme disorders
0.000 0.431 0.568
E58 Dietary calcium deficiency
0.000 0.435 0.565
D75.2 Essential thrombocytosis
0.000 0.437 0.563
E05.9 Thyrotoxicosis, unspecified
0.000 0.437 0.563
E56 Other vitamin deficiencies
0.000 0.441 0.559
D69 Purpura and other haemorrhagic conditions
0.000 0.442 0.558
D83.8 Other common variable immunodeficiencies
0.000 0.443 0.557
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.443 0.557
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.443 0.557
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.443 0.557
E14.1 With ketoacidosis
0.000 0.445 0.555
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.448 0.552
E65-E68 Obesity and other hyperalimentation
0.000 0.453 0.547
E03.5 Myxoedema coma
0.288 0.453 0.259
E03.4 Atrophy of thyroid (acquired)
0.288 0.453 0.259
E03.3 Postinfectious hypothyroidism
0.288 0.453 0.259
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.458 0.542
D57 Sickle-cell disorders
0.000 0.458 0.542
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.002 0.460 0.538
E03.0 Congenital hypothyroidism with diffuse goitre
0.285 0.462 0.252
E04 Other non-toxic goitre
0.001 0.463 0.536
D59.8 Other acquired haemolytic anaemias
0.000 0.466 0.534
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.466 0.534
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.466 0.534
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.466 0.534
D59.3 Haemolytic-uraemic syndrome
0.000 0.466 0.534
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.466 0.534
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.466 0.534
E07 Other disorders of thyroid
0.026 0.468 0.506
E03.1 Congenital hypothyroidism without goitre
0.254 0.469 0.277
E14.6 With other specified complications
0.000 0.472 0.528
E13.9 Without complications
0.000 0.475 0.525
E83.1 Disorders of iron metabolism
0.000 0.477 0.523
L40.8 Other psoriasis
0.000 0.478 0.522
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.480 0.520
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.299 0.484 0.217
E14.7 With multiple complications
0.000 0.485 0.515
E14.2 Withrenal complications
0.000 0.485 0.515
E14.0 With coma
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D67 Hereditary factor IX deficiency
0.000 0.488 0.512
E53.9 Vitamin B deficiency, unspecified
0.000 0.491 0.509
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.009 0.493 0.497
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.009 0.493 0.497
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.009 0.493 0.497
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.009 0.493 0.497
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.009 0.493 0.497
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.009 0.493 0.497
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.009 0.493 0.497
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.009 0.493 0.497
D50.8 Other iron deficiency anaemias
0.000 0.494 0.506
D81.9 Combined immunodeficiency, unspecified
0.000 0.494 0.506
D81.8 Other combined immunodeficiencies
0.000 0.494 0.506
D81.7 Major histocompatibility complex class II deficiency
0.000 0.494 0.506
D81.6 Major histocompatibility complex class I deficiency
0.000 0.494 0.506
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.494 0.506
D81.4 Nezelof's syndrome
0.000 0.494 0.506
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.494 0.506
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.494 0.506
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.494 0.506
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.494 0.506
D58 Other hereditary haemolytic anaemias
0.000 0.496 0.504
E13.8 With unspecified complications
0.000 0.496 0.504
E13.7 With multiple complications
0.000 0.496 0.504
E13.6 With other specified complications
0.000 0.496 0.504
E13.5 With peripheral circulatory complications
0.000 0.496 0.504
E13.4 With neurological complications
0.000 0.496 0.504
E13.2 With renal complications
0.000 0.496 0.504
E13.1 With ketoacidosis
0.000 0.496 0.504
E13.0 With coma
0.000 0.496 0.504
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.499 0.501
D75.1 Secondary polycythaemia
0.000 0.499 0.501
D74.9 Methaemoglobinaemia, unspecified
0.000 0.499 0.501
D74.8 Other methaemoglobinaemias
0.000 0.499 0.501
D74.0 Congenital methaemoglobinaemia
0.000 0.499 0.501
E70-E90 Metabolic disorders
0.000 0.504 0.496
E20-E35 Disorders of other endocrine glands
0.000 0.506 0.493
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.507 0.493
E45 Retarded development following protein-energy malnutrition
0.000 0.507 0.493
E43 Unspecified severe protein-energy malnutrition
0.000 0.507 0.493
E42 Marasmic kwashiorkor
0.000 0.507 0.493
E41 Nutritional marasmus
0.000 0.507 0.493
E40 Kwashiorkor
0.000 0.507 0.493
E51.2 Wernicke's encephalopathy
0.000 0.508 0.492
E53.8 Deficiency of other specified B group vitamins
0.000 0.509 0.491
K90 Intestinal malabsorption
0.000 0.510 0.490
E27.1 Primary adrenocortical insufficiency
0.000 0.512 0.488
E83 Disorders of mineral metabolism
0.000 0.513 0.487
E03.8 Other specified hypothyroidism
0.258 0.514 0.229
E27 Other disorders of adrenal gland
0.000 0.515 0.485
D50.1 Sideropenic dysphagia
0.000 0.516 0.484
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.516 0.484
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.516 0.484
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.516 0.484
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.516 0.484
D82.2 Immunodeficiency with short-limbed stature
0.000 0.516 0.484
D82.0 Wiskott-Aldrich syndrome
0.000 0.516 0.484
E06.4 Drug-induced thyroiditis
0.007 0.520 0.473
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.007 0.520 0.473
E06.0 Acute thyroiditis
0.007 0.520 0.473
D84.1 Defects in the complement system
0.000 0.523 0.476
E14.5 With peripheral circulatory complications
0.000 0.525 0.475
E53.1 Pyridoxine deficiency
0.000 0.525 0.474
E53.0 Riboflavin deficiency
0.000 0.525 0.474
E14.4 With neurological complications
0.000 0.526 0.474
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.533 0.466
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.533 0.466
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.533 0.466
D69.2 Other nonthrombocytopenic purpura
0.000 0.535 0.465
E13.3 With ophthalmic complications
0.000 0.536 0.464
E46 Unspecified protein-energy malnutrition
0.000 0.536 0.464
D52 Folate deficiency anaemia
0.000 0.536 0.463
D69.6 Thrombocytopenia, unspecified
0.000 0.537 0.463
E51.9 Thiamine deficiency, unspecified
0.000 0.538 0.462
E51.8 Other manifestations of thiamine deficiency
0.000 0.538 0.462
E51.1 Beriberi
0.000 0.538 0.462
D69.5 Secondary thrombocytopenia
0.000 0.541 0.459
E11.0 With coma
0.000 0.542 0.457
D82.1 Di George's syndrome
0.000 0.546 0.454
E88 Other metabolic disorders
0.000 0.551 0.449
E04.0 Non-toxic diffuse goitre
0.000 0.553 0.447
E06.3 Autoimmune thyroiditis
0.004 0.555 0.441
E50.9 Vitamin A deficiency, unspecified
0.000 0.559 0.440
E50.8 Other manifestations of vitamin A deficiency
0.000 0.559 0.440
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.559 0.440
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.559 0.440
E50.5 Vitamin A deficiency with night blindness
0.000 0.559 0.440
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.559 0.440
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.559 0.440
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.559 0.440
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.559 0.440
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.559 0.440
E63.9 Nutritional deficiency, unspecified
0.000 0.559 0.440
E63.8 Other specified nutritional deficiencies
0.000 0.559 0.440
E63.1 Imbalance of constituents of food intake
0.000 0.559 0.440
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.559 0.440
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.559 0.440
E64.8 Sequelae of other nutritional deficiencies
0.000 0.559 0.440
E64.3 Sequelae of rickets
0.000 0.559 0.440
E64.2 Sequelae of vitamin C deficiency
0.000 0.559 0.440
E64.1 Sequelae of vitamin A deficiency
0.000 0.559 0.440
E64.0 Sequelae of protein-energy malnutrition
0.000 0.559 0.440
E85 Amyloidosis
0.000 0.563 0.437
D84.8 Other specified immunodeficiencies
0.000 0.563 0.437
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.563 0.437
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.566 0.434
E61 Deficiency of other nutrient elements
0.000 0.566 0.433
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.576 0.424
E07.8 Other specified disorders of thyroid
0.013 0.579 0.408
D76.3 Other histiocytosis syndromes
0.000 0.581 0.419
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.583 0.417
E06.1 Subacute thyroiditis
0.008 0.585 0.407
E34 Other endocrine disorders
0.000 0.587 0.413
D69.9 Haemorrhagic condition, unspecified
0.000 0.589 0.411
D89.3 Immune reconstitution syndrome
0.000 0.590 0.410
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.591 0.409
K90.9 Intestinal malabsorption, unspecified
0.000 0.592 0.408
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.592 0.408
D55.8 Other anaemias due to enzyme disorders
0.000 0.592 0.408
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.592 0.408
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.592 0.408
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.592 0.408
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.592 0.408
E04.9 Non-toxic goitre, unspecified
0.000 0.595 0.405
E56.9 Vitamin deficiency, unspecified
0.000 0.599 0.401
E56.8 Deficiency of other vitamins
0.000 0.599 0.401
E56.0 Deficiency of vitamin E
0.000 0.599 0.401
D69.8 Other specified haemorrhagic conditions
0.000 0.600 0.400
E11.2 With renal complications
0.000 0.602 0.398
D89.1 Cryoglobulinaemia
0.000 0.606 0.394
E06.5 Other chronic thyroiditis
0.008 0.606 0.386
E67 Other hyperalimentation
0.000 0.607 0.392
E68 Sequelae of hyperalimentation
0.000 0.607 0.392
E85.4 Organ-limited amyloidosis
0.000 0.608 0.392
D57.8 Other sickle-cell disorders
0.000 0.611 0.388
D57.3 Sickle-cell trait
0.000 0.611 0.388
D57.2 Double heterozygous sickling disorders
0.000 0.611 0.388
D57.0 Sickle-cell anaemia with crisis
0.000 0.611 0.388
E04.8 Other specified non-toxic goitre
0.001 0.615 0.384
E07.1 Dyshormogenetic goitre
0.019 0.618 0.363
E07.0 Hypersecretion of calcitonin
0.019 0.618 0.363
E20 Hypoparathyroidism
0.000 0.619 0.380
D69.1 Qualitative platelet defects
0.000 0.622 0.378
E79 Disorders of purine and pyrimidine metabolism
0.000 0.626 0.374
D58.2 Other haemoglobinopathies
0.000 0.627 0.373
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.627 0.373
E70 Disorders of aromatic amino-acid metabolism
0.000 0.631 0.369
E34.9 Endocrine disorder, unspecified
0.000 0.634 0.366
E25 Adrenogenital disorders
0.000 0.634 0.366
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.638 0.362
D58.1 Hereditary elliptocytosis
0.000 0.638 0.362
D57.1 Sickle-cell anaemia without crisis
0.000 0.638 0.361
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.639 0.361
D56 Thalassaemia
0.001 0.641 0.358
E66 Obesity
0.000 0.643 0.357
E77 Disorders of glycoprotein metabolism
0.000 0.644 0.356
E76 Disorders of glycosaminoglycan metabolism
0.000 0.644 0.356
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.644 0.356
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.644 0.356
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.646 0.354
E32 Diseases of thymus
0.000 0.646 0.354
E31 Polyglandular dysfunction
0.000 0.646 0.354
E30 Disorders of puberty, not elsewhere classified
0.000 0.646 0.354
E44.1 Mild protein-energy malnutrition
0.000 0.646 0.353
E44.0 Moderate protein-energy malnutrition
0.000 0.646 0.353
D69.4 Other primary thrombocytopenia
0.000 0.647 0.353
E88.9 Metabolic disorder, unspecified
0.000 0.648 0.352
K90.3 Pancreatic steatorrhoea
0.000 0.649 0.351
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.649 0.351
K90.1 Tropical sprue
0.000 0.649 0.351
E83.8 Other disorders of mineral metabolism
0.000 0.650 0.349
E83.2 Disorders of zinc metabolism
0.000 0.650 0.349
E83.0 Disorders of copper metabolism
0.000 0.650 0.349
E27.5 Adrenomedullary hyperfunction
0.000 0.652 0.348
E27.0 Other adrenocortical overactivity
0.000 0.652 0.348
E56.1 Deficiency of vitamin K
0.000 0.654 0.345
E27.2 Addisonian crisis
0.000 0.656 0.344
K90.8 Other intestinal malabsorption
0.000 0.661 0.339
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.663 0.337
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.665 0.335
E84 Cystic fibrosis
0.000 0.667 0.333
D52.8 Other folate deficiency anaemias
0.000 0.667 0.332
D52.1 Drug-induced folate deficiency anaemia
0.000 0.667 0.332
D52.0 Dietary folate deficiency anaemia
0.000 0.667 0.332
E85.3 Secondary systemic amyloidosis
0.000 0.669 0.331
E34.0 Carcinoid syndrome
0.000 0.669 0.331
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.669 0.330
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.670 0.330
E72 Other disorders of amino-acid metabolism
0.000 0.673 0.327
E88.3 Tumour lysis syndrome
0.000 0.679 0.321
D60-D64 Aplastic and other anaemias
0.000 0.680 0.320
D58.0 Hereditary spherocytosis
0.000 0.680 0.319
E27.8 Other specified disorders of adrenal gland
0.000 0.682 0.318
E74 Other disorders of carbohydrate metabolism
0.000 0.686 0.314
E85.8 Other amyloidosis
0.000 0.686 0.313
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.686 0.313
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.686 0.313
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.686 0.313
E61.9 Deficiency of nutrient element, unspecified
0.000 0.689 0.311
E61.8 Deficiency of other specified nutrient elements
0.000 0.689 0.311
E61.7 Deficiency of multiple nutrient elements
0.000 0.689 0.311
E61.6 Vanadium deficiency
0.000 0.689 0.311
E61.5 Molybdenum deficiency
0.000 0.689 0.311
E61.4 Chromium deficiency
0.000 0.689 0.311
E61.3 Manganese deficiency
0.000 0.689 0.311
E61.0 Copper deficiency
0.000 0.689 0.311
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.691 0.309
E88.8 Other specified metabolic disorders
0.000 0.695 0.305
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.695 0.305
E85.9 Amyloidosis, unspecified
0.000 0.698 0.302
E20.9 Hypoparathyroidism, unspecified
0.000 0.700 0.299
E22 Hyperfunction of pituitary gland
0.000 0.701 0.298
E66.0 Obesity due to excess calories
0.000 0.703 0.297
E34.5 Androgen resistance syndrome
0.000 0.703 0.296
E34.4 Constitutional tall stature
0.000 0.703 0.296
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.703 0.296
E34.1 Other hypersecretion of intestinal hormones
0.000 0.703 0.296
E24 Cushing's syndrome
0.000 0.704 0.296
E04.1 Non-toxic single thyroid nodule
0.000 0.705 0.295
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.713 0.287
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.714 0.286
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.714 0.286
E29 Testicular dysfunction
0.000 0.715 0.285
E34.3 Short stature, not elsewhere classified
0.000 0.715 0.285
E65 Localised adiposity
0.000 0.716 0.283
E67.8 Other specified hyperalimentation
0.000 0.718 0.281
E67.3 Hypervitaminosis D
0.000 0.718 0.281
E67.2 Megavitamin-B6 syndrome
0.000 0.718 0.281
E67.1 Hypercarotenaemia
0.000 0.718 0.281
E67.0 Hypervitaminosis A
0.000 0.718 0.281
E70.3 Albinism
0.000 0.721 0.278
E73 Lactose intolerance
0.000 0.722 0.278
E88.2 Lipomatosis, not elsewhere classified
0.000 0.725 0.274
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.726 0.274
E61.2 Magnesium deficiency
0.000 0.727 0.273
E20.8 Other hypoparathyroidism
0.000 0.727 0.273
E20.1 Pseudohypoparathyroidism
0.000 0.727 0.273
E20.0 Idiopathic hypoparathyroidism
0.000 0.727 0.273
D73 Diseases of spleen
0.000 0.728 0.271
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.732 0.268
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.732 0.268
E79.1 Lesch-Nyhan syndrome
0.000 0.732 0.268
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.735 0.265
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.735 0.265
E70.2 Disorders of tyrosine metabolism
0.000 0.735 0.265
E70.1 Other hyperphenylalaninaemias
0.000 0.735 0.265
E70.0 Classical phenylketonuria
0.000 0.735 0.265
E25.9 Adrenogenital disorder, unspecified
0.000 0.738 0.262
E25.8 Other adrenogenital disorders
0.000 0.738 0.262
D84.9 Immunodeficiency, unspecified
0.001 0.738 0.261
D56.9 Thalassaemia, unspecified
0.001 0.742 0.257
D56.8 Other thalassaemias
0.001 0.742 0.257
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.742 0.257
D56.2 Delta-beta thalassaemia
0.001 0.742 0.257
D56.0 Alpha thalassaemia
0.001 0.742 0.257
E66.1 Drug-induced obesity
0.000 0.744 0.256
E14.9 Without complications
0.000 0.745 0.255
E71.3 Disorders of fatty-acid metabolism
0.000 0.745 0.255
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.745 0.255
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.745 0.255
E71.0 Maple-syrup-urine disease
0.000 0.745 0.255
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.745 0.255
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.745 0.255
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.745 0.255
E76.2 Other mucopolysaccharidoses
0.000 0.745 0.255
E76.1 Mucopolysaccharidosis, type II
0.000 0.745 0.255
E76.0 Mucopolysaccharidosis, type I
0.000 0.745 0.255
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.745 0.255
E77.8 Other disorders of glycoprotein metabolism
0.000 0.745 0.255
E77.1 Defects in glycoprotein degradation
0.000 0.745 0.255
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.745 0.255
E30.9 Disorder of puberty, unspecified
0.000 0.746 0.254
E30.8 Other disorders of puberty
0.000 0.746 0.254
E30.1 Precocious puberty
0.000 0.746 0.254
E30.0 Delayed puberty
0.000 0.746 0.254
E31.9 Polyglandular dysfunction, unspecified
0.000 0.746 0.254
E31.8 Other polyglandular dysfunction
0.000 0.746 0.254
E31.1 Polyglandular hyperfunction
0.000 0.746 0.254
E31.0 Autoimmune polyglandular failure
0.000 0.746 0.254
E32.9 Disease of thymus, unspecified
0.000 0.746 0.254
E32.8 Other diseases of thymus
0.000 0.746 0.254
E32.1 Abscess of thymus
0.000 0.746 0.254
E32.0 Persistent hyperplasia of thymus
0.000 0.746 0.254
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.746 0.254
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.746 0.254
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.746 0.254
E26 Hyperaldosteronism
0.000 0.753 0.246
E27.9 Disorder of adrenal gland, unspecified
0.000 0.758 0.241
E22.1 Hyperprolactinaemia
0.000 0.761 0.239
E84.8 Cystic fibrosis with other manifestations
0.000 0.761 0.239
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.761 0.239
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.761 0.239
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.766 0.234
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.766 0.234
E72.5 Disorders of glycine metabolism
0.000 0.766 0.234
E72.4 Disorders of ornithine metabolism
0.000 0.766 0.234
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.766 0.234
E72.2 Disorders of urea cycle metabolism
0.000 0.766 0.234
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.766 0.234
E34.8 Other specified endocrine disorders
0.000 0.767 0.233
D61 Other aplastic anaemias
0.000 0.767 0.233
E24.0 Pituitary-dependent Cushing's disease
0.000 0.770 0.230
E66.8 Other obesity
0.000 0.771 0.229
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.775 0.225
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.775 0.225
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.775 0.225
E74.2 Disorders of galactose metabolism
0.000 0.775 0.225
E74.1 Disorders of fructose metabolism
0.000 0.775 0.225
E74.0 Glycogen storage disease
0.000 0.775 0.225
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.779 0.221
E84.9 Cystic fibrosis, unspecified
0.000 0.784 0.216
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.786 0.214
E22.8 Other hyperfunction of pituitary gland
0.000 0.786 0.214
E86 Volume depletion
0.000 0.787 0.213
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.788 0.212
E24.3 Ectopic ACTH syndrome
0.000 0.788 0.212

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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