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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517474
log Bayes Factor = 114.938
Chromosome 6   position 31,046,494  (GRCh37) Explore rs2517474 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
R31 Unspecified haematuria
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E03.9 Hypothyroidism, unspecified
0.999 0.001 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E10.2 With renal complications
0.000 0.023 0.977
L40.0 Psoriasis vulgaris
0.969 0.031 0.000
E83.1 Disorders of iron metabolism
0.000 0.038 0.962
E10.4 With neurological complications
0.000 0.039 0.961
E70-E90 Metabolic disorders
0.000 0.060 0.940
E83 Disorders of mineral metabolism
0.000 0.061 0.939
L40.8 Other psoriasis
0.915 0.085 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.089 0.911
E20-E35 Disorders of other endocrine glands
0.000 0.092 0.908
E27 Other disorders of adrenal gland
0.000 0.096 0.904
D86.9 Sarcoidosis, unspecified
0.000 0.110 0.890
E10.5 With peripheral circulatory complications
0.000 0.115 0.885
D86 Sarcoidosis
0.000 0.118 0.882
J33.0 Polyp of nasal cavity
0.000 0.127 0.873
D80-D89 Certain disorders involving the immune mechanism
0.000 0.130 0.870
E05.9 Thyrotoxicosis, unspecified
0.000 0.132 0.868
E14 Unspecified diabetes mellitus
0.000 0.134 0.866
E10.0 With coma
0.000 0.147 0.853
E10.8 With unspecified complications
0.000 0.154 0.846
E50-E64 Other nutritional deficiencies
0.000 0.157 0.843
E85 Amyloidosis
0.000 0.164 0.836
E78.0 Pure hypercholesterolaemia
0.826 0.174 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.179 0.821
D80 Immunodeficiency with predominantly antibody defects
0.000 0.179 0.821
E10.6 With other specified complications
0.000 0.181 0.819
E05.8 Other thyrotoxicosis
0.000 0.183 0.817
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.191 0.809
E34 Other endocrine disorders
0.000 0.194 0.806
D69 Purpura and other haemorrhagic conditions
0.000 0.197 0.803
E20 Hypoparathyroidism
0.000 0.198 0.802
L40.1 Generalised pustular psoriasis
0.801 0.199 0.000
D69.6 Thrombocytopenia, unspecified
0.000 0.199 0.801
L40.4 Guttate psoriasis
0.792 0.208 0.000
D86.1 Sarcoidosis of lymph nodes
0.000 0.218 0.782
E03 Other hypothyroidism
0.542 0.219 0.239
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.225 0.775
D50-D53 Nutritional anaemias
0.000 0.225 0.775
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.235 0.765
D51 Vitamin B12 deficiency anaemia
0.000 0.235 0.765
E14.3 With ophthalmic complications
0.000 0.248 0.752
E88 Other metabolic disorders
0.000 0.250 0.750
E14.8 With unspecified complications
0.000 0.253 0.747
E55 Vitamin D deficiency
0.000 0.254 0.746
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.264 0.736
E20.9 Hypoparathyroidism, unspecified
0.000 0.274 0.726
E73 Lactose intolerance
0.000 0.278 0.722
E79 Disorders of purine and pyrimidine metabolism
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.715
E16.3 Increased secretion of glucagon
0.000 0.284 0.715
D83 Common variable immunodeficiency
0.000 0.289 0.711
E34.9 Endocrine disorder, unspecified
0.000 0.290 0.710
E14.1 With ketoacidosis
0.000 0.290 0.710
E06 Thyroiditis
0.000 0.299 0.701
E70 Disorders of aromatic amino-acid metabolism
0.000 0.299 0.700
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.302 0.698
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.304 0.696
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.304 0.696
E14.6 With other specified complications
0.000 0.305 0.694
E85.4 Organ-limited amyloidosis
0.000 0.308 0.692
J33 Nasal polyp
0.000 0.310 0.690
E29 Testicular dysfunction
0.000 0.321 0.679
E55.9 Vitamin D deficiency, unspecified
0.000 0.323 0.677
E34.0 Carcinoid syndrome
0.000 0.324 0.676
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.325 0.675
E77 Disorders of glycoprotein metabolism
0.000 0.326 0.674
E76 Disorders of glycosaminoglycan metabolism
0.000 0.326 0.674
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.326 0.674
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.326 0.674
E83.8 Other disorders of mineral metabolism
0.000 0.327 0.673
E83.2 Disorders of zinc metabolism
0.000 0.327 0.673
E83.0 Disorders of copper metabolism
0.000 0.327 0.673
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.329 0.671
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.329 0.671
E85.9 Amyloidosis, unspecified
0.000 0.330 0.670
E51 Thiamine deficiency
0.000 0.331 0.669
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.331 0.668
E84 Cystic fibrosis
0.000 0.332 0.668
D86.8 Sarcoidosis of other and combined sites
0.000 0.333 0.667
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.336 0.664
E85.3 Secondary systemic amyloidosis
0.000 0.339 0.661
D69.5 Secondary thrombocytopenia
0.000 0.348 0.652
E53 Deficiency of other B group vitamins
0.000 0.349 0.651
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.349 0.651
E32 Diseases of thymus
0.000 0.349 0.651
E31 Polyglandular dysfunction
0.000 0.349 0.651
E30 Disorders of puberty, not elsewhere classified
0.000 0.349 0.651
E27.5 Adrenomedullary hyperfunction
0.000 0.352 0.648
E27.0 Other adrenocortical overactivity
0.000 0.352 0.648
D53 Other nutritional anaemias
0.000 0.353 0.647
D69.2 Other nonthrombocytopenic purpura
0.000 0.353 0.646
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.358 0.642
D81 Combined immunodeficiencies
0.000 0.376 0.624
E14.7 With multiple complications
0.000 0.379 0.621
E14.2 Withrenal complications
0.000 0.379 0.621
E14.0 With coma
0.000 0.379 0.621
E54 Ascorbic acid deficiency
0.000 0.379 0.621
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.380 0.619
J33.8 Other polyp of sinus
0.000 0.383 0.617
E22 Hyperfunction of pituitary gland
0.000 0.384 0.616
D69.9 Haemorrhagic condition, unspecified
0.000 0.386 0.614
D67 Hereditary factor IX deficiency
0.000 0.386 0.613
E72 Other disorders of amino-acid metabolism
0.000 0.387 0.613
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.388 0.612
J33.9 Nasal polyp, unspecified
0.000 0.389 0.611
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.395 0.604
E63 Other nutritional deficiencies
0.000 0.395 0.604
E50 Vitamin A deficiency
0.000 0.395 0.604
E60 Dietary zinc deficiency
0.000 0.395 0.604
E59 Dietary selenium deficiency
0.000 0.395 0.604
E52 Niacin deficiency [pellagra]
0.000 0.395 0.604
E16.1 Other hypoglycaemia
0.000 0.400 0.600
E85.8 Other amyloidosis
0.000 0.401 0.599
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.401 0.599
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.401 0.599
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.401 0.599
K90 Intestinal malabsorption
0.000 0.401 0.599
E27.8 Other specified disorders of adrenal gland
0.000 0.402 0.598
D83.9 Common variable immunodeficiency, unspecified
0.000 0.402 0.598
E06.9 Thyroiditis, unspecified
0.000 0.403 0.597
E86 Volume depletion
0.000 0.403 0.597
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.411 0.588
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.411 0.588
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.411 0.588
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.411 0.588
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.411 0.588
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.412 0.588
D66 Hereditary factor VIII deficiency
0.000 0.417 0.583
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.421 0.579
E88.9 Metabolic disorder, unspecified
0.000 0.421 0.579
E40-E46 Malnutrition
0.000 0.422 0.578
E34.5 Androgen resistance syndrome
0.000 0.422 0.578
E34.4 Constitutional tall stature
0.000 0.422 0.578
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.422 0.578
E34.1 Other hypersecretion of intestinal hormones
0.000 0.422 0.578
E58 Dietary calcium deficiency
0.000 0.424 0.576
D69.8 Other specified haemorrhagic conditions
0.000 0.424 0.576
E20.8 Other hypoparathyroidism
0.000 0.425 0.575
E20.1 Pseudohypoparathyroidism
0.000 0.425 0.575
E20.0 Idiopathic hypoparathyroidism
0.000 0.425 0.575
E27.2 Addisonian crisis
0.000 0.425 0.575
E03.0 Congenital hypothyroidism with diffuse goitre
0.428 0.427 0.145
D82 Immunodeficiency associated with other major defects
0.000 0.427 0.573
E74 Other disorders of carbohydrate metabolism
0.000 0.430 0.569
E73.9 Lactose intolerance, unspecified
0.000 0.435 0.565
L40.3 Pustulosis palmaris et plantaris
0.565 0.435 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.440 0.560
E03.5 Myxoedema coma
0.389 0.440 0.171
E03.4 Atrophy of thyroid (acquired)
0.389 0.440 0.171
E03.3 Postinfectious hypothyroidism
0.389 0.440 0.171
E56 Other vitamin deficiencies
0.000 0.444 0.556
D53.9 Nutritional anaemia, unspecified
0.000 0.444 0.556
E14.5 With peripheral circulatory complications
0.000 0.444 0.556
E65-E68 Obesity and other hyperalimentation
0.000 0.445 0.555
D70 Agranulocytosis
0.000 0.446 0.554
E25 Adrenogenital disorders
0.000 0.451 0.549
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.452 0.548
D51.2 Transcobalamin II deficiency
0.000 0.452 0.548
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.452 0.548
D72 Other disorders of white blood cells
0.000 0.453 0.547
E34.3 Short stature, not elsewhere classified
0.000 0.453 0.546
E51.2 Wernicke's encephalopathy
0.000 0.455 0.544
D69.1 Qualitative platelet defects
0.000 0.458 0.542
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.397 0.458 0.145
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.459 0.541
E13 Other specified diabetes mellitus
0.000 0.461 0.539
D84 Other immunodeficiencies
0.000 0.465 0.535
E55.0 Rickets, active
0.000 0.465 0.535
E34.8 Other specified endocrine disorders
0.000 0.465 0.535
E70.3 Albinism
0.000 0.471 0.529
E53.9 Vitamin B deficiency, unspecified
0.000 0.473 0.527
K90.9 Intestinal malabsorption, unspecified
0.000 0.473 0.527
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.475 0.525
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.476 0.524
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.476 0.524
D86.0 Sarcoidosis of lung
0.000 0.479 0.521
E03.1 Congenital hypothyroidism without goitre
0.335 0.479 0.186
E73.8 Other lactose intolerance
0.000 0.482 0.517
E73.1 Secondary lactase deficiency
0.000 0.482 0.517
E73.0 Congenital lactase deficiency
0.000 0.482 0.517
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.485 0.515
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.485 0.515
E79.1 Lesch-Nyhan syndrome
0.000 0.485 0.515
E29.1 Testicular hypofunction
0.000 0.485 0.515
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
D86.3 Sarcoidosis of skin
0.000 0.487 0.512
E03.8 Other specified hypothyroidism
0.377 0.488 0.135
E88.3 Tumour lysis syndrome
0.000 0.489 0.510
D83.8 Other common variable immunodeficiencies
0.000 0.490 0.510
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.490 0.510
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.490 0.510
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.490 0.510
E06.4 Drug-induced thyroiditis
0.000 0.497 0.502
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.497 0.502
E06.0 Acute thyroiditis
0.000 0.497 0.502
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.498 0.502
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.498 0.502
E70.2 Disorders of tyrosine metabolism
0.000 0.498 0.502
E70.1 Other hyperphenylalaninaemias
0.000 0.498 0.502
E70.0 Classical phenylketonuria
0.000 0.498 0.502
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.500 0.500
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.501 0.499
E26 Hyperaldosteronism
0.000 0.502 0.497
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.503 0.497
E14.4 With neurological complications
0.000 0.507 0.492
D75 Other diseases of blood and blood-forming organs
0.000 0.511 0.489
E06.3 Autoimmune thyroiditis
0.000 0.512 0.488
E29.9 Testicular dysfunction, unspecified
0.000 0.513 0.487
E29.8 Other testicular dysfunction
0.000 0.513 0.487
E29.0 Testicular hyperfunction
0.000 0.513 0.487
E22.1 Hyperprolactinaemia
0.000 0.514 0.485
D69.4 Other primary thrombocytopenia
0.000 0.515 0.485
E71.3 Disorders of fatty-acid metabolism
0.000 0.517 0.483
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.517 0.483
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.517 0.483
E71.0 Maple-syrup-urine disease
0.000 0.517 0.483
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.517 0.483
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.517 0.483
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.517 0.483
E76.2 Other mucopolysaccharidoses
0.000 0.517 0.483
E76.1 Mucopolysaccharidosis, type II
0.000 0.517 0.483
E76.0 Mucopolysaccharidosis, type I
0.000 0.517 0.483
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.517 0.483
E77.8 Other disorders of glycoprotein metabolism
0.000 0.517 0.483
E77.1 Defects in glycoprotein degradation
0.000 0.517 0.483
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.517 0.483
D72.8 Other specified disorders of white blood cells
0.000 0.517 0.483
E51.9 Thiamine deficiency, unspecified
0.000 0.520 0.480
E51.8 Other manifestations of thiamine deficiency
0.000 0.520 0.480
E51.1 Beriberi
0.000 0.520 0.480
D89.3 Immune reconstitution syndrome
0.000 0.521 0.479
E84.8 Cystic fibrosis with other manifestations
0.000 0.521 0.479
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.521 0.479
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.521 0.479
E07 Other disorders of thyroid
0.001 0.522 0.477
E88.8 Other specified metabolic disorders
0.000 0.524 0.476
E84.9 Cystic fibrosis, unspecified
0.000 0.527 0.473
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.529 0.471
D89.1 Cryoglobulinaemia
0.000 0.533 0.467
E53.1 Pyridoxine deficiency
0.000 0.533 0.467
E53.0 Riboflavin deficiency
0.000 0.533 0.467
E61 Deficiency of other nutrient elements
0.000 0.533 0.467
E30.9 Disorder of puberty, unspecified
0.000 0.533 0.467
E30.8 Other disorders of puberty
0.000 0.533 0.467
E30.1 Precocious puberty
0.000 0.533 0.467
E30.0 Delayed puberty
0.000 0.533 0.467
E31.9 Polyglandular dysfunction, unspecified
0.000 0.533 0.467
E31.8 Other polyglandular dysfunction
0.000 0.533 0.467
E31.1 Polyglandular hyperfunction
0.000 0.533 0.467
E31.0 Autoimmune polyglandular failure
0.000 0.533 0.467
E32.9 Disease of thymus, unspecified
0.000 0.533 0.467
E32.8 Other diseases of thymus
0.000 0.533 0.467
E32.1 Abscess of thymus
0.000 0.533 0.467
E32.0 Persistent hyperplasia of thymus
0.000 0.533 0.467
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.533 0.467
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.533 0.467
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.533 0.467
D53.8 Other specified nutritional anaemias
0.000 0.536 0.464
D53.2 Scorbutic anaemia
0.000 0.536 0.464
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.536 0.464
D53.0 Protein deficiency anaemia
0.000 0.536 0.464
D74 Methaemoglobinaemia
0.000 0.539 0.461
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.539 0.461
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.539 0.461
E22.0 Acromegaly and pituitary gigantism
0.000 0.544 0.456
E88.2 Lipomatosis, not elsewhere classified
0.000 0.544 0.456
E06.1 Subacute thyroiditis
0.000 0.546 0.454
D81.9 Combined immunodeficiency, unspecified
0.000 0.552 0.447
D81.8 Other combined immunodeficiencies
0.000 0.552 0.447
D81.7 Major histocompatibility complex class II deficiency
0.000 0.552 0.447
D81.6 Major histocompatibility complex class I deficiency
0.000 0.552 0.447
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.552 0.447
D81.4 Nezelof's syndrome
0.000 0.552 0.447
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.552 0.447
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.552 0.447
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.552 0.447
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.552 0.447
K90.8 Other intestinal malabsorption
0.000 0.553 0.447
J33.1 Polypoid sinus degeneration
0.000 0.553 0.446
E53.8 Deficiency of other specified B group vitamins
0.000 0.554 0.446
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.556 0.444
E80.1 Porphyria cutanea tarda
0.000 0.557 0.442
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.558 0.442
E22.8 Other hyperfunction of pituitary gland
0.000 0.558 0.442
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.560 0.439
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.560 0.439
E72.5 Disorders of glycine metabolism
0.000 0.560 0.439
E72.4 Disorders of ornithine metabolism
0.000 0.560 0.439
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.560 0.439
E72.2 Disorders of urea cycle metabolism
0.000 0.560 0.439
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.560 0.439
E50.9 Vitamin A deficiency, unspecified
0.000 0.566 0.433
E50.8 Other manifestations of vitamin A deficiency
0.000 0.566 0.433
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.566 0.433
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.566 0.433
E50.5 Vitamin A deficiency with night blindness
0.000 0.566 0.433
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.566 0.433
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.566 0.433
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.566 0.433
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.566 0.433
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.566 0.433
E63.9 Nutritional deficiency, unspecified
0.000 0.566 0.433
E63.8 Other specified nutritional deficiencies
0.000 0.566 0.433
E63.1 Imbalance of constituents of food intake
0.000 0.566 0.433
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.566 0.433
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.566 0.433
E64.8 Sequelae of other nutritional deficiencies
0.000 0.566 0.433
E64.3 Sequelae of rickets
0.000 0.566 0.433
E64.2 Sequelae of vitamin C deficiency
0.000 0.566 0.433
E64.1 Sequelae of vitamin A deficiency
0.000 0.566 0.433
E64.0 Sequelae of protein-energy malnutrition
0.000 0.566 0.433
E04 Other non-toxic goitre
0.000 0.567 0.433
K90.3 Pancreatic steatorrhoea
0.000 0.570 0.429
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.570 0.429
K90.1 Tropical sprue
0.000 0.570 0.429
D55-D59 Haemolytic anaemias
0.000 0.580 0.420
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.581 0.419
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.585 0.415
E45 Retarded development following protein-energy malnutrition
0.000 0.585 0.415
E43 Unspecified severe protein-energy malnutrition
0.000 0.585 0.415
E42 Marasmic kwashiorkor
0.000 0.585 0.415
E41 Nutritional marasmus
0.000 0.585 0.415
E40 Kwashiorkor
0.000 0.585 0.415
D84.1 Defects in the complement system
0.000 0.587 0.413
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.589 0.411
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.589 0.411
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.589 0.411
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.589 0.411
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.589 0.411
D82.2 Immunodeficiency with short-limbed stature
0.000 0.589 0.411
D82.0 Wiskott-Aldrich syndrome
0.000 0.589 0.411
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.591 0.408
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.591 0.408
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.591 0.408
E74.2 Disorders of galactose metabolism
0.000 0.591 0.408
E74.1 Disorders of fructose metabolism
0.000 0.591 0.408
E80.2 Other porphyria
0.000 0.592 0.408
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.596 0.404
E56.9 Vitamin deficiency, unspecified
0.000 0.601 0.399
E56.8 Deficiency of other vitamins
0.000 0.601 0.399
E56.0 Deficiency of vitamin E
0.000 0.601 0.399
E67 Other hyperalimentation
0.000 0.602 0.398
E68 Sequelae of hyperalimentation
0.000 0.602 0.398
E06.5 Other chronic thyroiditis
0.000 0.604 0.396
E25.9 Adrenogenital disorder, unspecified
0.000 0.606 0.394
E25.8 Other adrenogenital disorders
0.000 0.606 0.394
D72.9 Disorder of white blood cells, unspecified
0.000 0.607 0.392
D72.0 Genetic anomalies of leukocytes
0.000 0.607 0.392
E24 Cushing's syndrome
0.000 0.609 0.391
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.029 0.611 0.360
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.612 0.388
E80.5 Crigler-Najjar syndrome
0.000 0.612 0.388
E80.3 Defects of catalase and peroxydase
0.000 0.612 0.388
E80.0 Hereditary erythropoietic porphyria
0.000 0.612 0.388
E13.8 With unspecified complications
0.000 0.613 0.386
E13.7 With multiple complications
0.000 0.613 0.386
E13.6 With other specified complications
0.000 0.613 0.386
E13.5 With peripheral circulatory complications
0.000 0.613 0.386
E13.4 With neurological complications
0.000 0.613 0.386
E13.2 With renal complications
0.000 0.613 0.386
E13.1 With ketoacidosis
0.000 0.613 0.386
E13.0 With coma
0.000 0.613 0.386
E74.0 Glycogen storage disease
0.000 0.615 0.385
D72.1 Eosinophilia
0.000 0.616 0.384
D84.8 Other specified immunodeficiencies
0.000 0.616 0.384
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.616 0.384
D75.0 Familial erythrocytosis
0.000 0.618 0.382
E72.0 Disorders of amino-acid transport
0.000 0.621 0.378
D52 Folate deficiency anaemia
0.000 0.624 0.376
E14.9 Without complications
0.000 0.627 0.373
E04.9 Non-toxic goitre, unspecified
0.000 0.632 0.368
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.633 0.367
D75.2 Essential thrombocytosis
0.000 0.637 0.363
E07.8 Other specified disorders of thyroid
0.001 0.638 0.361
D82.1 Di George's syndrome
0.000 0.640 0.359
E13.3 With ophthalmic complications
0.000 0.640 0.359
E26.8 Other hyperaldosteronism
0.000 0.643 0.357
E26.1 Secondary hyperaldosteronism
0.000 0.643 0.357
E75.6 Lipid storage disorder, unspecified
0.001 0.643 0.356
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.643 0.356
E75.3 Sphingolipidosis, unspecified
0.001 0.643 0.356
E75.1 Other gangliosidosis
0.001 0.643 0.356
E75.0 GM2 gangliosidosis
0.001 0.643 0.356
E56.1 Deficiency of vitamin K
0.000 0.649 0.350
E07.1 Dyshormogenetic goitre
0.001 0.657 0.342
E07.0 Hypersecretion of calcitonin
0.001 0.657 0.342
D69.0 Allergic purpura
0.001 0.660 0.339
E83.3 Disorders of phosphorus metabolism
0.000 0.661 0.339
E66 Obesity
0.000 0.661 0.339
L40-L45 Papulosquamous disorders
0.338 0.662 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.662 0.337
E61.9 Deficiency of nutrient element, unspecified
0.000 0.665 0.335
E61.8 Deficiency of other specified nutrient elements
0.000 0.665 0.335
E61.7 Deficiency of multiple nutrient elements
0.000 0.665 0.335
E61.6 Vanadium deficiency
0.000 0.665 0.335
E61.5 Molybdenum deficiency
0.000 0.665 0.335
E61.4 Chromium deficiency
0.000 0.665 0.335
E61.3 Manganese deficiency
0.000 0.665 0.335
E61.0 Copper deficiency
0.000 0.665 0.335
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.669 0.331
D74.9 Methaemoglobinaemia, unspecified
0.000 0.670 0.330
D74.8 Other methaemoglobinaemias
0.000 0.670 0.330
D74.0 Congenital methaemoglobinaemia
0.000 0.670 0.330
E04.0 Non-toxic diffuse goitre
0.000 0.672 0.328
E65 Localised adiposity
0.000 0.677 0.323
D59 Acquired haemolytic anaemia
0.000 0.677 0.323
E80.6 Other disorders of bilirubin metabolism
0.000 0.680 0.320
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.681 0.318
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.681 0.318
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.681 0.318
E26.9 Hyperaldosteronism, unspecified
0.000 0.682 0.318
E83.4 Disorders of magnesium metabolism
0.000 0.682 0.318
E78.9 Disorder of lipoprotein metabolism, unspecified
0.006 0.682 0.312
E28 Ovarian dysfunction
0.001 0.682 0.317
E61.2 Magnesium deficiency
0.000 0.686 0.314
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.687 0.313
E04.8 Other specified non-toxic goitre
0.000 0.689 0.310
E27.9 Disorder of adrenal gland, unspecified
0.001 0.691 0.308
D76.3 Other histiocytosis syndromes
0.000 0.698 0.302
D55 Anaemia due to enzyme disorders
0.000 0.698 0.301
E44.1 Mild protein-energy malnutrition
0.000 0.702 0.297
E44.0 Moderate protein-energy malnutrition
0.000 0.702 0.297
E75.5 Other lipid storage disorders
0.001 0.706 0.293
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.708 0.292
E83.5 Disorders of calcium metabolism
0.000 0.708 0.292
D57 Sickle-cell disorders
0.000 0.712 0.288
E78.3 Hyperchylomicronaemia
0.020 0.714 0.266
E67.8 Other specified hyperalimentation
0.000 0.714 0.285
E67.3 Hypervitaminosis D
0.000 0.714 0.285
E67.2 Megavitamin-B6 syndrome
0.000 0.714 0.285
E67.1 Hypercarotenaemia
0.000 0.714 0.285
E67.0 Hypervitaminosis A
0.000 0.714 0.285
E78.4 Other hyperlipidaemia
0.015 0.715 0.270
E66.8 Other obesity
0.000 0.717 0.283
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.719 0.280
E24.3 Ectopic ACTH syndrome
0.000 0.719 0.280
E24.1 Nelson's syndrome
0.000 0.719 0.280
E78.2 Mixed hyperlipidaemia
0.011 0.720 0.269
E24.8 Other Cushing's syndrome
0.000 0.722 0.278
E75.2 Other sphingolipidosis
0.001 0.722 0.277
E46 Unspecified protein-energy malnutrition
0.000 0.724 0.276
E78.6 Lipoprotein deficiency
0.020 0.725 0.255
D52.8 Other folate deficiency anaemias
0.000 0.730 0.270
D52.1 Drug-induced folate deficiency anaemia
0.000 0.730 0.270
D52.0 Dietary folate deficiency anaemia
0.000 0.730 0.270
E11 Non-insulin-dependent diabetes mellitus
0.000 0.733 0.267
E26.0 Primary hyperaldosteronism
0.000 0.733 0.267
E24.2 Drug-induced Cushing's syndrome
0.000 0.734 0.266
E78.1 Pure hyperglyceridaemia
0.018 0.737 0.244
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.741 0.259
E13.9 Without complications
0.000 0.742 0.258
E66.0 Obesity due to excess calories
0.000 0.745 0.255
L42 Pityriasis rosea
0.254 0.746 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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