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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517510
log Bayes Factor = 72.3209
Chromosome 6   position 31,030,122  (GRCh37) Explore rs2517510 on Ensembl!
Variant rs2517510 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.001 0.999
E10-E14 Diabetes mellitus
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E10.9 Without complications
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.006 0.994
D86.9 Sarcoidosis, unspecified
0.000 0.006 0.994
D86 Sarcoidosis
0.000 0.006 0.994
D80-D89 Certain disorders involving the immune mechanism
0.000 0.014 0.986
L40 Psoriasis
0.000 0.018 0.982
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.019 0.981
E00-E07 Disorders of thyroid gland
0.036 0.020 0.944
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.024 0.976
D70 Agranulocytosis
0.000 0.028 0.972
L40.5 Arthropathic psoriasis
0.000 0.037 0.963
E05 Thyrotoxicosis [hyperthyroidism]
0.006 0.051 0.943
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.053 0.947
D50-D53 Nutritional anaemias
0.000 0.057 0.943
L40.0 Psoriasis vulgaris
0.000 0.068 0.932
D86.1 Sarcoidosis of lymph nodes
0.000 0.084 0.916
D51 Vitamin B12 deficiency anaemia
0.000 0.087 0.913
E11 Non-insulin-dependent diabetes mellitus
0.000 0.098 0.902
E10.2 With renal complications
0.000 0.106 0.894
E10.8 With unspecified complications
0.000 0.107 0.893
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.139 0.861
E10.4 With neurological complications
0.000 0.140 0.860
D72 Other disorders of white blood cells
0.000 0.144 0.856
D86.0 Sarcoidosis of lung
0.000 0.152 0.848
E10.5 With peripheral circulatory complications
0.000 0.158 0.842
E50-E64 Other nutritional deficiencies
0.000 0.160 0.840
E11.5 With peripheral circulatory complications
0.000 0.168 0.832
E10.6 With other specified complications
0.000 0.186 0.814
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.193 0.807
D53 Other nutritional anaemias
0.000 0.193 0.807
D80 Immunodeficiency with predominantly antibody defects
0.000 0.194 0.806
D86.3 Sarcoidosis of skin
0.000 0.198 0.802
E11.3 With ophthalmic complications
0.000 0.199 0.801
E11.4 With neurological complications
0.000 0.200 0.800
D55-D59 Haemolytic anaemias
0.000 0.202 0.798
E55 Vitamin D deficiency
0.000 0.206 0.794
D75 Other diseases of blood and blood-forming organs
0.000 0.207 0.793
D86.8 Sarcoidosis of other and combined sites
0.000 0.208 0.792
D72.8 Other specified disorders of white blood cells
0.000 0.218 0.782
D83 Common variable immunodeficiency
0.000 0.221 0.779
E10.0 With coma
0.000 0.236 0.764
E03 Other hypothyroidism
0.408 0.236 0.356
E55.9 Vitamin D deficiency, unspecified
0.000 0.238 0.762
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.239 0.761
L40.4 Guttate psoriasis
0.000 0.241 0.759
D59 Acquired haemolytic anaemia
0.000 0.250 0.750
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.253 0.747
L40.1 Generalised pustular psoriasis
0.000 0.267 0.733
E11.8 With unspecified complications
0.000 0.268 0.732
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E11.1 With ketoacidosis
0.000 0.286 0.714
E14 Unspecified diabetes mellitus
0.000 0.287 0.713
D53.9 Nutritional anaemia, unspecified
0.000 0.291 0.709
D81 Combined immunodeficiencies
0.000 0.293 0.707
E13 Other specified diabetes mellitus
0.000 0.295 0.704
L40.3 Pustulosis palmaris et plantaris
0.000 0.296 0.704
L40.2 Acrodermatitis continua
0.000 0.296 0.704
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.026 0.297 0.677
E00 Congenital iodine-deficiency syndrome
0.026 0.297 0.677
D74 Methaemoglobinaemia
0.000 0.300 0.700
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.300 0.700
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.300 0.700
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.317 0.683
E16.1 Other hypoglycaemia
0.000 0.318 0.681
E05.5 Thyroid crisis or storm
0.004 0.319 0.676
E05.4 Thyrotoxicosis factitia
0.004 0.319 0.676
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.004 0.319 0.676
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.004 0.319 0.676
E02 Subclinical iodine-deficiency hypothyroidism
0.025 0.321 0.654
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.322 0.678
D82 Immunodeficiency associated with other major defects
0.000 0.323 0.677
D50 Iron deficiency anaemia
0.000 0.323 0.677
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.323 0.677
E40-E46 Malnutrition
0.000 0.324 0.676
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.326 0.674
E11.6 With other specified complications
0.000 0.332 0.668
E06 Thyroiditis
0.019 0.332 0.649
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.345 0.655
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.345 0.655
D51.2 Transcobalamin II deficiency
0.000 0.345 0.655
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.345 0.655
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.347 0.653
D59.1 Other autoimmune haemolytic anaemias
0.000 0.349 0.651
E11.7 With multiple complications
0.000 0.353 0.647
E05.8 Other thyrotoxicosis
0.004 0.360 0.636
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.367 0.633
E51 Thiamine deficiency
0.000 0.368 0.632
D83.9 Common variable immunodeficiency, unspecified
0.000 0.369 0.631
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.375 0.625
D75.0 Familial erythrocytosis
0.000 0.378 0.622
D72.9 Disorder of white blood cells, unspecified
0.000 0.386 0.614
D72.0 Genetic anomalies of leukocytes
0.000 0.386 0.614
D69 Purpura and other haemorrhagic conditions
0.000 0.387 0.613
D66 Hereditary factor VIII deficiency
0.000 0.392 0.608
E14.3 With ophthalmic complications
0.000 0.397 0.603
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.398 0.602
E63 Other nutritional deficiencies
0.000 0.398 0.602
E50 Vitamin A deficiency
0.000 0.398 0.602
E60 Dietary zinc deficiency
0.000 0.398 0.602
E59 Dietary selenium deficiency
0.000 0.398 0.602
E52 Niacin deficiency [pellagra]
0.000 0.398 0.602
E53 Deficiency of other B group vitamins
0.000 0.399 0.601
D50.9 Iron deficiency anaemia, unspecified
0.000 0.400 0.600
D84 Other immunodeficiencies
0.000 0.402 0.598
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.403 0.597
D53.8 Other specified nutritional anaemias
0.000 0.421 0.579
D53.2 Scorbutic anaemia
0.000 0.421 0.579
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.421 0.579
D53.0 Protein deficiency anaemia
0.000 0.421 0.579
E54 Ascorbic acid deficiency
0.000 0.422 0.578
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.422 0.578
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.422 0.578
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.422 0.578
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.422 0.578
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.422 0.578
E05.9 Thyrotoxicosis, unspecified
0.000 0.422 0.577
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.423 0.577
D75.2 Essential thrombocytosis
0.000 0.425 0.575
D72.1 Eosinophilia
0.000 0.426 0.573
D55 Anaemia due to enzyme disorders
0.000 0.428 0.572
E55.0 Rickets, active
0.000 0.430 0.569
E14.8 With unspecified complications
0.000 0.434 0.566
E06.9 Thyroiditis, unspecified
0.008 0.435 0.557
E83.1 Disorders of iron metabolism
0.000 0.438 0.562
D83.8 Other common variable immunodeficiencies
0.000 0.441 0.559
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.441 0.559
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.441 0.559
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.441 0.559
E58 Dietary calcium deficiency
0.000 0.446 0.554
E14.1 With ketoacidosis
0.000 0.449 0.551
E56 Other vitamin deficiencies
0.000 0.452 0.548
E03.5 Myxoedema coma
0.293 0.452 0.255
E03.4 Atrophy of thyroid (acquired)
0.293 0.452 0.255
E03.3 Postinfectious hypothyroidism
0.293 0.452 0.255
D67 Hereditary factor IX deficiency
0.000 0.454 0.546
D57 Sickle-cell disorders
0.000 0.455 0.545
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.460 0.540
E03.0 Congenital hypothyroidism with diffuse goitre
0.290 0.461 0.249
D59.8 Other acquired haemolytic anaemias
0.000 0.462 0.538
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.462 0.538
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.462 0.538
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.462 0.538
D59.3 Haemolytic-uraemic syndrome
0.000 0.462 0.538
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.462 0.538
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.462 0.538
E70-E90 Metabolic disorders
0.000 0.464 0.536
E03.1 Congenital hypothyroidism without goitre
0.258 0.469 0.273
D69.6 Thrombocytopenia, unspecified
0.000 0.469 0.531
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.004 0.469 0.527
E13.9 Without complications
0.000 0.472 0.528
E83 Disorders of mineral metabolism
0.000 0.474 0.526
E07 Other disorders of thyroid
0.049 0.475 0.477
L40.8 Other psoriasis
0.000 0.479 0.521
E65-E68 Obesity and other hyperalimentation
0.000 0.481 0.519
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.304 0.483 0.214
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.483 0.516
D75.1 Secondary polycythaemia
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E14.6 With other specified complications
0.000 0.488 0.511
D69.2 Other nonthrombocytopenic purpura
0.000 0.489 0.511
E14.7 With multiple complications
0.000 0.489 0.511
E14.2 Withrenal complications
0.000 0.489 0.511
E14.0 With coma
0.000 0.489 0.511
D58 Other hereditary haemolytic anaemias
0.000 0.491 0.508
D81.9 Combined immunodeficiency, unspecified
0.000 0.493 0.507
D81.8 Other combined immunodeficiencies
0.000 0.493 0.507
D81.7 Major histocompatibility complex class II deficiency
0.000 0.493 0.507
D81.6 Major histocompatibility complex class I deficiency
0.000 0.493 0.507
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.493 0.507
D81.4 Nezelof's syndrome
0.000 0.493 0.507
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.493 0.507
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.493 0.507
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.493 0.507
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.493 0.507
E13.8 With unspecified complications
0.000 0.495 0.505
E13.7 With multiple complications
0.000 0.495 0.505
E13.6 With other specified complications
0.000 0.495 0.505
E13.5 With peripheral circulatory complications
0.000 0.495 0.505
E13.4 With neurological complications
0.000 0.495 0.505
E13.2 With renal complications
0.000 0.495 0.505
E13.1 With ketoacidosis
0.000 0.495 0.505
E13.0 With coma
0.000 0.495 0.505
D50.8 Other iron deficiency anaemias
0.000 0.496 0.504
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.019 0.496 0.485
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.019 0.496 0.485
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.019 0.496 0.485
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.019 0.496 0.485
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.019 0.496 0.485
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.019 0.496 0.485
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.019 0.496 0.485
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.019 0.496 0.485
D74.9 Methaemoglobinaemia, unspecified
0.000 0.498 0.502
D74.8 Other methaemoglobinaemias
0.000 0.498 0.502
D74.0 Congenital methaemoglobinaemia
0.000 0.498 0.502
D69.5 Secondary thrombocytopenia
0.000 0.505 0.495
E14.5 With peripheral circulatory complications
0.000 0.506 0.493
E04 Other non-toxic goitre
0.002 0.508 0.490
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.510 0.490
E03.8 Other specified hypothyroidism
0.261 0.513 0.226
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.514 0.485
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.514 0.485
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.514 0.485
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.514 0.485
D82.2 Immunodeficiency with short-limbed stature
0.000 0.514 0.485
D82.0 Wiskott-Aldrich syndrome
0.000 0.514 0.485
D50.1 Sideropenic dysphagia
0.000 0.515 0.485
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.515 0.485
E45 Retarded development following protein-energy malnutrition
0.000 0.515 0.485
E43 Unspecified severe protein-energy malnutrition
0.000 0.515 0.485
E42 Marasmic kwashiorkor
0.000 0.515 0.485
E41 Nutritional marasmus
0.000 0.515 0.485
E40 Kwashiorkor
0.000 0.515 0.485
E51.2 Wernicke's encephalopathy
0.000 0.517 0.483
E06.4 Drug-induced thyroiditis
0.014 0.521 0.465
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.014 0.521 0.465
E06.0 Acute thyroiditis
0.014 0.521 0.465
E88 Other metabolic disorders
0.000 0.524 0.476
E85 Amyloidosis
0.000 0.527 0.473
D52 Folate deficiency anaemia
0.000 0.529 0.470
E14.4 With neurological complications
0.000 0.529 0.471
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.532 0.468
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.532 0.468
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.532 0.468
D84.1 Defects in the complement system
0.000 0.532 0.468
E13.3 With ophthalmic complications
0.000 0.534 0.466
E20-E35 Disorders of other endocrine glands
0.000 0.537 0.463
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.542 0.458
E27.1 Primary adrenocortical insufficiency
0.000 0.543 0.457
K90 Intestinal malabsorption
0.000 0.544 0.456
D82.1 Di George's syndrome
0.000 0.545 0.455
E27 Other disorders of adrenal gland
0.000 0.546 0.454
E51.9 Thiamine deficiency, unspecified
0.000 0.547 0.453
E51.8 Other manifestations of thiamine deficiency
0.000 0.547 0.453
E51.1 Beriberi
0.000 0.547 0.453
E53.9 Vitamin B deficiency, unspecified
0.000 0.548 0.452
D69.9 Haemorrhagic condition, unspecified
0.000 0.548 0.452
E46 Unspecified protein-energy malnutrition
0.000 0.554 0.446
E06.3 Autoimmune thyroiditis
0.007 0.556 0.437
D69.8 Other specified haemorrhagic conditions
0.000 0.561 0.439
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.562 0.438
E50.9 Vitamin A deficiency, unspecified
0.000 0.568 0.432
E50.8 Other manifestations of vitamin A deficiency
0.000 0.568 0.432
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.568 0.432
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.568 0.432
E50.5 Vitamin A deficiency with night blindness
0.000 0.568 0.432
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.568 0.432
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.568 0.432
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.568 0.432
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.568 0.432
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.568 0.432
E63.9 Nutritional deficiency, unspecified
0.000 0.568 0.432
E63.8 Other specified nutritional deficiencies
0.000 0.568 0.432
E63.1 Imbalance of constituents of food intake
0.000 0.568 0.432
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.568 0.432
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.568 0.432
E64.8 Sequelae of other nutritional deficiencies
0.000 0.568 0.432
E64.3 Sequelae of rickets
0.000 0.568 0.432
E64.2 Sequelae of vitamin C deficiency
0.000 0.568 0.432
E64.1 Sequelae of vitamin A deficiency
0.000 0.568 0.432
E64.0 Sequelae of protein-energy malnutrition
0.000 0.568 0.432
E53.1 Pyridoxine deficiency
0.000 0.569 0.431
E53.0 Riboflavin deficiency
0.000 0.569 0.431
D84.8 Other specified immunodeficiencies
0.000 0.571 0.428
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.571 0.428
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.572 0.428
E61 Deficiency of other nutrient elements
0.000 0.573 0.427
E85.4 Organ-limited amyloidosis
0.000 0.575 0.425
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.576 0.424
D76.3 Other histiocytosis syndromes
0.000 0.579 0.421
D69.1 Qualitative platelet defects
0.000 0.584 0.416
E06.1 Subacute thyroiditis
0.015 0.585 0.400
D89.3 Immune reconstitution syndrome
0.000 0.586 0.413
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.590 0.410
D55.8 Other anaemias due to enzyme disorders
0.000 0.590 0.410
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.590 0.410
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.590 0.410
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.590 0.410
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.590 0.410
E04.0 Non-toxic diffuse goitre
0.001 0.591 0.408
E53.8 Deficiency of other specified B group vitamins
0.000 0.593 0.407
E11.0 With coma
0.000 0.594 0.406
E79 Disorders of purine and pyrimidine metabolism
0.000 0.596 0.404
E07.8 Other specified disorders of thyroid
0.025 0.598 0.377
E70 Disorders of aromatic amino-acid metabolism
0.000 0.601 0.399
D89.1 Cryoglobulinaemia
0.000 0.602 0.398
E06.5 Other chronic thyroiditis
0.015 0.605 0.380
E56.9 Vitamin deficiency, unspecified
0.000 0.607 0.393
E56.8 Deficiency of other vitamins
0.000 0.607 0.393
E56.0 Deficiency of vitamin E
0.000 0.607 0.393
D57.8 Other sickle-cell disorders
0.000 0.609 0.391
D57.3 Sickle-cell trait
0.000 0.609 0.391
D57.2 Double heterozygous sickling disorders
0.000 0.609 0.391
D57.0 Sickle-cell anaemia with crisis
0.000 0.609 0.391
E34 Other endocrine disorders
0.000 0.611 0.389
D69.4 Other primary thrombocytopenia
0.000 0.612 0.388
E77 Disorders of glycoprotein metabolism
0.000 0.616 0.384
E76 Disorders of glycosaminoglycan metabolism
0.000 0.616 0.384
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.616 0.384
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.616 0.384
E11.2 With renal complications
0.000 0.616 0.384
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.617 0.383
E04.9 Non-toxic goitre, unspecified
0.000 0.618 0.381
E83.8 Other disorders of mineral metabolism
0.000 0.623 0.377
E83.2 Disorders of zinc metabolism
0.000 0.623 0.377
E83.0 Disorders of copper metabolism
0.000 0.623 0.377
E07.1 Dyshormogenetic goitre
0.035 0.623 0.342
E07.0 Hypersecretion of calcitonin
0.035 0.623 0.342
D58.2 Other haemoglobinopathies
0.000 0.623 0.376
E88.9 Metabolic disorder, unspecified
0.000 0.628 0.372
E67 Other hyperalimentation
0.000 0.628 0.372
E68 Sequelae of hyperalimentation
0.000 0.628 0.372
K90.9 Intestinal malabsorption, unspecified
0.000 0.631 0.369
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.635 0.364
D58.1 Hereditary elliptocytosis
0.000 0.635 0.364
D57.1 Sickle-cell anaemia without crisis
0.000 0.636 0.364
E20 Hypoparathyroidism
0.000 0.636 0.364
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.638 0.362
D56 Thalassaemia
0.001 0.638 0.361
E84 Cystic fibrosis
0.000 0.640 0.360
E85.3 Secondary systemic amyloidosis
0.000 0.641 0.358
E72 Other disorders of amino-acid metabolism
0.000 0.647 0.353
E04.8 Other specified non-toxic goitre
0.002 0.647 0.351
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.651 0.349
E44.1 Mild protein-energy malnutrition
0.000 0.652 0.348
E44.0 Moderate protein-energy malnutrition
0.000 0.652 0.348
E34.9 Endocrine disorder, unspecified
0.000 0.655 0.345
E25 Adrenogenital disorders
0.000 0.657 0.343
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.660 0.340
E88.3 Tumour lysis syndrome
0.000 0.660 0.339
E56.1 Deficiency of vitamin K
0.000 0.661 0.339
E85.8 Other amyloidosis
0.000 0.661 0.339
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.661 0.339
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.661 0.339
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.661 0.339
D52.8 Other folate deficiency anaemias
0.000 0.662 0.337
D52.1 Drug-induced folate deficiency anaemia
0.000 0.662 0.337
D52.0 Dietary folate deficiency anaemia
0.000 0.662 0.337
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.664 0.336
E66 Obesity
0.000 0.665 0.335
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.666 0.333
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.668 0.332
E32 Diseases of thymus
0.000 0.668 0.332
E31 Polyglandular dysfunction
0.000 0.668 0.332
E30 Disorders of puberty, not elsewhere classified
0.000 0.668 0.332
E74 Other disorders of carbohydrate metabolism
0.000 0.672 0.328
E85.9 Amyloidosis, unspecified
0.000 0.673 0.327
K90.3 Pancreatic steatorrhoea
0.000 0.673 0.327
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.673 0.327
K90.1 Tropical sprue
0.000 0.673 0.327
E27.5 Adrenomedullary hyperfunction
0.000 0.674 0.326
E27.0 Other adrenocortical overactivity
0.000 0.674 0.326
E88.8 Other specified metabolic disorders
0.000 0.677 0.323
E27.2 Addisonian crisis
0.000 0.677 0.323
D58.0 Hereditary spherocytosis
0.000 0.677 0.322
E86 Volume depletion
0.000 0.681 0.319
K90.8 Other intestinal malabsorption
0.000 0.684 0.316
E34.0 Carcinoid syndrome
0.000 0.688 0.311
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.690 0.309
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.691 0.309
E61.9 Deficiency of nutrient element, unspecified
0.000 0.694 0.306
E61.8 Deficiency of other specified nutrient elements
0.000 0.694 0.306
E61.7 Deficiency of multiple nutrient elements
0.000 0.694 0.306
E61.6 Vanadium deficiency
0.000 0.694 0.306
E61.5 Molybdenum deficiency
0.000 0.694 0.306
E61.4 Chromium deficiency
0.000 0.694 0.306
E61.3 Manganese deficiency
0.000 0.694 0.306
E61.0 Copper deficiency
0.000 0.694 0.306
D60-D64 Aplastic and other anaemias
0.000 0.697 0.303
E70.3 Albinism
0.000 0.699 0.301
E73 Lactose intolerance
0.000 0.699 0.300
E27.8 Other specified disorders of adrenal gland
0.000 0.701 0.299
E20.9 Hypoparathyroidism, unspecified
0.000 0.708 0.292
E88.2 Lipomatosis, not elsewhere classified
0.000 0.709 0.291
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.710 0.290
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.710 0.290
E79.1 Lesch-Nyhan syndrome
0.000 0.710 0.290
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.711 0.289
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.714 0.286
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.714 0.286
E70.2 Disorders of tyrosine metabolism
0.000 0.714 0.286
E70.1 Other hyperphenylalaninaemias
0.000 0.714 0.286
E70.0 Classical phenylketonuria
0.000 0.714 0.286
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.714 0.286
E34.5 Androgen resistance syndrome
0.000 0.721 0.279
E34.4 Constitutional tall stature
0.000 0.721 0.279
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.721 0.279
E34.1 Other hypersecretion of intestinal hormones
0.000 0.721 0.279
E24 Cushing's syndrome
0.000 0.721 0.279
E66.0 Obesity due to excess calories
0.000 0.722 0.278
E71.3 Disorders of fatty-acid metabolism
0.000 0.724 0.275
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.724 0.275
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.724 0.275
E71.0 Maple-syrup-urine disease
0.000 0.724 0.275
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.724 0.275
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.724 0.275
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.724 0.275
E76.2 Other mucopolysaccharidoses
0.000 0.724 0.275
E76.1 Mucopolysaccharidosis, type II
0.000 0.724 0.275
E76.0 Mucopolysaccharidosis, type I
0.000 0.724 0.275
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.724 0.275
E77.8 Other disorders of glycoprotein metabolism
0.000 0.724 0.275
E77.1 Defects in glycoprotein degradation
0.000 0.724 0.275
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.724 0.275
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.726 0.274
E61.2 Magnesium deficiency
0.000 0.730 0.269
E22 Hyperfunction of pituitary gland
0.000 0.731 0.269
E34.3 Short stature, not elsewhere classified
0.000 0.732 0.268
E29 Testicular dysfunction
0.000 0.732 0.268
E67.8 Other specified hyperalimentation
0.000 0.733 0.267
E67.3 Hypervitaminosis D
0.000 0.733 0.267
E67.2 Megavitamin-B6 syndrome
0.000 0.733 0.267
E67.1 Hypercarotenaemia
0.000 0.733 0.267
E67.0 Hypervitaminosis A
0.000 0.733 0.267
D73 Diseases of spleen
0.000 0.737 0.263
E20.8 Other hypoparathyroidism
0.000 0.739 0.261
E20.1 Pseudohypoparathyroidism
0.000 0.739 0.261
E20.0 Idiopathic hypoparathyroidism
0.000 0.739 0.261
D56.9 Thalassaemia, unspecified
0.001 0.740 0.259
D56.8 Other thalassaemias
0.001 0.740 0.259
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.740 0.259
D56.2 Delta-beta thalassaemia
0.001 0.740 0.259
D56.0 Alpha thalassaemia
0.001 0.740 0.259
E84.8 Cystic fibrosis with other manifestations
0.000 0.742 0.258
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.742 0.258
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.742 0.258
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.743 0.257
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.747 0.253
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.747 0.253
E72.5 Disorders of glycine metabolism
0.000 0.747 0.253
E72.4 Disorders of ornithine metabolism
0.000 0.747 0.253
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.747 0.253
E72.2 Disorders of urea cycle metabolism
0.000 0.747 0.253
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.747 0.253
E25.9 Adrenogenital disorder, unspecified
0.000 0.754 0.246
E25.8 Other adrenogenital disorders
0.000 0.754 0.246
E65 Localised adiposity
0.000 0.755 0.245
S64.4 Injury of digital nerve of other finger
0.243 0.757 0.000
E66.1 Drug-induced obesity
0.000 0.760 0.240
E30.9 Disorder of puberty, unspecified
0.000 0.762 0.238
E30.8 Other disorders of puberty
0.000 0.762 0.238
E30.1 Precocious puberty
0.000 0.762 0.238
E30.0 Delayed puberty
0.000 0.762 0.238
E31.9 Polyglandular dysfunction, unspecified
0.000 0.762 0.238
E31.8 Other polyglandular dysfunction
0.000 0.762 0.238
E31.1 Polyglandular hyperfunction
0.000 0.762 0.238
E31.0 Autoimmune polyglandular failure
0.000 0.762 0.238
E32.9 Disease of thymus, unspecified
0.000 0.762 0.238
E32.8 Other diseases of thymus
0.000 0.762 0.238
E32.1 Abscess of thymus
0.000 0.762 0.238
E32.0 Persistent hyperplasia of thymus
0.000 0.762 0.238
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.762 0.238
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.762 0.238
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.762 0.238
D84.9 Immunodeficiency, unspecified
0.001 0.764 0.235
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.765 0.235
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.765 0.235
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.765 0.235
E74.2 Disorders of galactose metabolism
0.000 0.765 0.235
E74.1 Disorders of fructose metabolism
0.000 0.765 0.235
E74.0 Glycogen storage disease
0.000 0.765 0.235
E84.9 Cystic fibrosis, unspecified
0.000 0.766 0.234
E26 Hyperaldosteronism
0.000 0.768 0.232
E75.6 Lipid storage disorder, unspecified
0.000 0.778 0.222
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.778 0.222
E75.3 Sphingolipidosis, unspecified
0.000 0.778 0.222
E75.1 Other gangliosidosis
0.000 0.778 0.222
E75.0 GM2 gangliosidosis
0.000 0.778 0.222
E72.0 Disorders of amino-acid transport
0.000 0.778 0.222
E34.8 Other specified endocrine disorders
0.000 0.780 0.219
E04.1 Non-toxic single thyroid nodule
0.001 0.780 0.219
E14.9 Without complications
0.000 0.781 0.219
E24.0 Pituitary-dependent Cushing's disease
0.000 0.783 0.216
E73.8 Other lactose intolerance
0.000 0.784 0.216
E73.1 Secondary lactase deficiency
0.000 0.784 0.216

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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