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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2517516
log Bayes Factor = 72.1021
Chromosome 6   position 31,028,920  (GRCh37) Explore rs2517516 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E10.9 Without complications
0.000 0.005 0.995
E10.3 With ophthalmic complications
0.000 0.007 0.993
L40 Psoriasis
0.000 0.012 0.988
E00-E07 Disorders of thyroid gland
0.036 0.016 0.948
D86.9 Sarcoidosis, unspecified
0.000 0.025 0.975
L40.5 Arthropathic psoriasis
0.000 0.026 0.974
D86 Sarcoidosis
0.000 0.026 0.974
D80-D89 Certain disorders involving the immune mechanism
0.000 0.046 0.954
E05 Thyrotoxicosis [hyperthyroidism]
0.006 0.047 0.947
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.050 0.950
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.058 0.942
L40.0 Psoriasis vulgaris
0.000 0.059 0.941
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.065 0.935
D70 Agranulocytosis
0.000 0.070 0.930
E11 Non-insulin-dependent diabetes mellitus
0.000 0.083 0.917
D86.1 Sarcoidosis of lymph nodes
0.000 0.087 0.913
E10.2 With renal complications
0.000 0.107 0.893
E10.8 With unspecified complications
0.000 0.108 0.892
D50-D53 Nutritional anaemias
0.000 0.109 0.891
D51 Vitamin B12 deficiency anaemia
0.000 0.133 0.867
E10.4 With neurological complications
0.000 0.144 0.856
E11.5 With peripheral circulatory complications
0.000 0.145 0.855
E50-E64 Other nutritional deficiencies
0.000 0.153 0.847
E10.5 With peripheral circulatory complications
0.000 0.160 0.840
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.177 0.823
E11.4 With neurological complications
0.000 0.178 0.822
D72 Other disorders of white blood cells
0.000 0.179 0.821
E11.3 With ophthalmic complications
0.000 0.184 0.816
D86.0 Sarcoidosis of lung
0.000 0.184 0.816
E10.6 With other specified complications
0.000 0.186 0.813
E10.0 With coma
0.000 0.203 0.797
E55 Vitamin D deficiency
0.000 0.207 0.793
D80 Immunodeficiency with predominantly antibody defects
0.000 0.224 0.776
D86.8 Sarcoidosis of other and combined sites
0.000 0.225 0.775
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.227 0.773
E03 Other hypothyroidism
0.378 0.233 0.390
L40.4 Guttate psoriasis
0.000 0.237 0.763
D53 Other nutritional anaemias
0.000 0.239 0.761
E55.9 Vitamin D deficiency, unspecified
0.000 0.245 0.755
D86.3 Sarcoidosis of skin
0.000 0.247 0.753
D83 Common variable immunodeficiency
0.000 0.247 0.753
D75 Other diseases of blood and blood-forming organs
0.000 0.251 0.749
D72.8 Other specified disorders of white blood cells
0.000 0.253 0.747
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.254 0.746
E11.8 With unspecified complications
0.000 0.258 0.742
L40.1 Generalised pustular psoriasis
0.000 0.264 0.736
D55-D59 Haemolytic anaemias
0.000 0.266 0.734
E11.1 With ketoacidosis
0.000 0.277 0.723
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E14 Unspecified diabetes mellitus
0.000 0.288 0.712
L40.3 Pustulosis palmaris et plantaris
0.000 0.291 0.708
L40.2 Acrodermatitis continua
0.000 0.291 0.708
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.026 0.294 0.679
E00 Congenital iodine-deficiency syndrome
0.026 0.294 0.679
E13 Other specified diabetes mellitus
0.000 0.300 0.700
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.300 0.700
E40-E46 Malnutrition
0.000 0.315 0.685
E06 Thyroiditis
0.019 0.315 0.666
D81 Combined immunodeficiencies
0.000 0.316 0.684
E05.5 Thyroid crisis or storm
0.004 0.317 0.679
E05.4 Thyrotoxicosis factitia
0.004 0.317 0.679
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.004 0.317 0.679
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.004 0.317 0.679
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.318 0.682
D59 Acquired haemolytic anaemia
0.000 0.319 0.681
E02 Subclinical iodine-deficiency hypothyroidism
0.025 0.319 0.656
E16.1 Other hypoglycaemia
0.000 0.319 0.680
E11.6 With other specified complications
0.000 0.324 0.676
D74 Methaemoglobinaemia
0.000 0.329 0.670
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.329 0.670
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.329 0.670
D53.9 Nutritional anaemia, unspecified
0.000 0.332 0.668
E11.7 With multiple complications
0.000 0.343 0.657
D82 Immunodeficiency associated with other major defects
0.000 0.345 0.654
E53 Deficiency of other B group vitamins
0.000 0.346 0.654
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.353 0.647
E05.8 Other thyrotoxicosis
0.004 0.358 0.638
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.362 0.638
E51 Thiamine deficiency
0.000 0.363 0.637
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.376 0.624
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.378 0.622
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.378 0.622
D51.2 Transcobalamin II deficiency
0.000 0.378 0.622
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.378 0.622
D83.9 Common variable immunodeficiency, unspecified
0.000 0.391 0.609
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.391 0.608
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.392 0.608
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.393 0.607
E63 Other nutritional deficiencies
0.000 0.393 0.607
E50 Vitamin A deficiency
0.000 0.393 0.607
E60 Dietary zinc deficiency
0.000 0.393 0.607
E59 Dietary selenium deficiency
0.000 0.393 0.607
E52 Niacin deficiency [pellagra]
0.000 0.393 0.607
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.399 0.601
E14.3 With ophthalmic complications
0.000 0.401 0.599
D72.9 Disorder of white blood cells, unspecified
0.000 0.411 0.588
D72.0 Genetic anomalies of leukocytes
0.000 0.411 0.588
D75.0 Familial erythrocytosis
0.000 0.412 0.588
E54 Ascorbic acid deficiency
0.000 0.417 0.583
D59.1 Other autoimmune haemolytic anaemias
0.000 0.419 0.581
E06.9 Thyroiditis, unspecified
0.008 0.421 0.571
D84 Other immunodeficiencies
0.000 0.423 0.577
E55.0 Rickets, active
0.000 0.431 0.569
D66 Hereditary factor VIII deficiency
0.000 0.431 0.569
E14.8 With unspecified complications
0.000 0.435 0.565
E05.9 Thyrotoxicosis, unspecified
0.000 0.435 0.564
D72.1 Eosinophilia
0.000 0.436 0.564
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.440 0.560
D69 Purpura and other haemorrhagic conditions
0.000 0.441 0.559
E58 Dietary calcium deficiency
0.000 0.441 0.558
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.443 0.557
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.443 0.557
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.443 0.557
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.443 0.557
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.443 0.557
E56 Other vitamin deficiencies
0.000 0.447 0.552
E14.1 With ketoacidosis
0.000 0.449 0.551
E03.5 Myxoedema coma
0.271 0.450 0.279
E03.4 Atrophy of thyroid (acquired)
0.271 0.450 0.279
E03.3 Postinfectious hypothyroidism
0.271 0.450 0.279
E07 Other disorders of thyroid
0.053 0.451 0.497
D53.8 Other specified nutritional anaemias
0.000 0.454 0.546
D53.2 Scorbutic anaemia
0.000 0.454 0.546
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.454 0.546
D53.0 Protein deficiency anaemia
0.000 0.454 0.546
E04 Other non-toxic goitre
0.002 0.455 0.543
E03.0 Congenital hypothyroidism with diffuse goitre
0.269 0.459 0.272
D75.2 Essential thrombocytosis
0.000 0.460 0.540
D83.8 Other common variable immunodeficiencies
0.000 0.460 0.540
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.460 0.540
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.460 0.540
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.460 0.540
E03.1 Congenital hypothyroidism without goitre
0.239 0.462 0.299
E65-E68 Obesity and other hyperalimentation
0.000 0.466 0.534
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.468 0.532
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.004 0.471 0.525
E83.1 Disorders of iron metabolism
0.000 0.472 0.528
D55 Anaemia due to enzyme disorders
0.000 0.473 0.526
E14.6 With other specified complications
0.000 0.476 0.524
L40.8 Other psoriasis
0.000 0.477 0.522
E13.9 Without complications
0.000 0.478 0.522
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.480 0.519
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.281 0.485 0.234
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D67 Hereditary factor IX deficiency
0.000 0.488 0.512
E14.7 With multiple complications
0.000 0.489 0.511
E14.2 Withrenal complications
0.000 0.489 0.511
E14.0 With coma
0.000 0.489 0.511
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.019 0.494 0.487
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.019 0.494 0.487
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.019 0.494 0.487
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.019 0.494 0.487
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.019 0.494 0.487
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.019 0.494 0.487
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.019 0.494 0.487
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.019 0.494 0.487
E70-E90 Metabolic disorders
0.000 0.495 0.505
E53.9 Vitamin B deficiency, unspecified
0.000 0.497 0.503
E13.8 With unspecified complications
0.000 0.498 0.502
E13.7 With multiple complications
0.000 0.498 0.502
E13.6 With other specified complications
0.000 0.498 0.502
E13.5 With peripheral circulatory complications
0.000 0.498 0.502
E13.4 With neurological complications
0.000 0.498 0.502
E13.2 With renal complications
0.000 0.498 0.502
E13.1 With ketoacidosis
0.000 0.498 0.502
E13.0 With coma
0.000 0.498 0.502
D57 Sickle-cell disorders
0.000 0.498 0.501
E83 Disorders of mineral metabolism
0.000 0.505 0.495
E14.5 With peripheral circulatory complications
0.000 0.507 0.493
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.508 0.491
E45 Retarded development following protein-energy malnutrition
0.000 0.508 0.491
E43 Unspecified severe protein-energy malnutrition
0.000 0.508 0.491
E42 Marasmic kwashiorkor
0.000 0.508 0.491
E41 Nutritional marasmus
0.000 0.508 0.491
E40 Kwashiorkor
0.000 0.508 0.491
E06.4 Drug-induced thyroiditis
0.014 0.509 0.478
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.014 0.509 0.478
E06.0 Acute thyroiditis
0.014 0.509 0.478
D81.9 Combined immunodeficiency, unspecified
0.000 0.509 0.490
D81.8 Other combined immunodeficiencies
0.000 0.509 0.490
D81.7 Major histocompatibility complex class II deficiency
0.000 0.509 0.490
D81.6 Major histocompatibility complex class I deficiency
0.000 0.509 0.490
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.509 0.490
D81.4 Nezelof's syndrome
0.000 0.509 0.490
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.509 0.490
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.509 0.490
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.509 0.490
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.509 0.490
E03.8 Other specified hypothyroidism
0.229 0.510 0.262
D59.8 Other acquired haemolytic anaemias
0.000 0.512 0.488
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.512 0.488
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.512 0.488
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.512 0.488
D59.3 Haemolytic-uraemic syndrome
0.000 0.512 0.488
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.512 0.488
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.512 0.488
E51.2 Wernicke's encephalopathy
0.000 0.514 0.486
E53.8 Deficiency of other specified B group vitamins
0.000 0.514 0.486
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.516 0.484
D74.9 Methaemoglobinaemia, unspecified
0.000 0.519 0.481
D74.8 Other methaemoglobinaemias
0.000 0.519 0.481
D74.0 Congenital methaemoglobinaemia
0.000 0.519 0.481
D75.1 Secondary polycythaemia
0.000 0.521 0.479
E06.3 Autoimmune thyroiditis
0.007 0.526 0.467
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.528 0.472
D50 Iron deficiency anaemia
0.000 0.529 0.471
D69.6 Thrombocytopenia, unspecified
0.000 0.530 0.470
E14.4 With neurological complications
0.000 0.530 0.470
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.531 0.469
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.531 0.469
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.531 0.469
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.531 0.469
D82.2 Immunodeficiency with short-limbed stature
0.000 0.531 0.469
D82.0 Wiskott-Aldrich syndrome
0.000 0.531 0.469
E53.1 Pyridoxine deficiency
0.000 0.531 0.469
E53.0 Riboflavin deficiency
0.000 0.531 0.469
E20-E35 Disorders of other endocrine glands
0.000 0.532 0.468
D58 Other hereditary haemolytic anaemias
0.000 0.534 0.466
D69.2 Other nonthrombocytopenic purpura
0.000 0.534 0.466
E13.3 With ophthalmic complications
0.000 0.537 0.463
E27.1 Primary adrenocortical insufficiency
0.000 0.538 0.462
E46 Unspecified protein-energy malnutrition
0.000 0.539 0.461
D69.5 Secondary thrombocytopenia
0.000 0.541 0.459
E27 Other disorders of adrenal gland
0.000 0.541 0.459
E88 Other metabolic disorders
0.000 0.543 0.457
E51.9 Thiamine deficiency, unspecified
0.000 0.543 0.457
E51.8 Other manifestations of thiamine deficiency
0.000 0.543 0.457
E51.1 Beriberi
0.000 0.543 0.457
E85 Amyloidosis
0.000 0.545 0.455
E04.0 Non-toxic diffuse goitre
0.001 0.547 0.452
D84.1 Defects in the complement system
0.000 0.548 0.451
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.552 0.447
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.552 0.447
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.552 0.447
K90 Intestinal malabsorption
0.000 0.555 0.445
D82.1 Di George's syndrome
0.000 0.560 0.440
D52 Folate deficiency anaemia
0.000 0.563 0.436
E50.9 Vitamin A deficiency, unspecified
0.000 0.564 0.435
E50.8 Other manifestations of vitamin A deficiency
0.000 0.564 0.435
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.564 0.435
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.564 0.435
E50.5 Vitamin A deficiency with night blindness
0.000 0.564 0.435
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.564 0.435
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.564 0.435
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.564 0.435
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.564 0.435
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.564 0.435
E63.9 Nutritional deficiency, unspecified
0.000 0.564 0.435
E63.8 Other specified nutritional deficiencies
0.000 0.564 0.435
E63.1 Imbalance of constituents of food intake
0.000 0.564 0.435
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.564 0.435
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.564 0.435
E64.8 Sequelae of other nutritional deficiencies
0.000 0.564 0.435
E64.3 Sequelae of rickets
0.000 0.564 0.435
E64.2 Sequelae of vitamin C deficiency
0.000 0.564 0.435
E64.1 Sequelae of vitamin A deficiency
0.000 0.564 0.435
E64.0 Sequelae of protein-energy malnutrition
0.000 0.564 0.435
E61 Deficiency of other nutrient elements
0.000 0.573 0.427
E07.8 Other specified disorders of thyroid
0.026 0.574 0.400
E06.1 Subacute thyroiditis
0.015 0.574 0.411
E85.4 Organ-limited amyloidosis
0.000 0.583 0.417
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.584 0.416
E04.9 Non-toxic goitre, unspecified
0.000 0.584 0.415
D84.8 Other specified immunodeficiencies
0.000 0.586 0.414
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.586 0.414
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.588 0.412
D69.9 Haemorrhagic condition, unspecified
0.000 0.589 0.411
E06.5 Other chronic thyroiditis
0.015 0.595 0.390
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.596 0.404
D76.3 Other histiocytosis syndromes
0.000 0.599 0.401
D69.8 Other specified haemorrhagic conditions
0.000 0.599 0.401
E56.9 Vitamin deficiency, unspecified
0.000 0.604 0.396
E56.8 Deficiency of other vitamins
0.000 0.604 0.396
E56.0 Deficiency of vitamin E
0.000 0.604 0.396
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.605 0.395
E07.1 Dyshormogenetic goitre
0.038 0.606 0.356
E07.0 Hypersecretion of calcitonin
0.038 0.606 0.356
E11.0 With coma
0.001 0.606 0.393
E34 Other endocrine disorders
0.000 0.609 0.391
E04.8 Other specified non-toxic goitre
0.002 0.609 0.389
E11.2 With renal complications
0.000 0.615 0.385
E67 Other hyperalimentation
0.000 0.617 0.383
E68 Sequelae of hyperalimentation
0.000 0.617 0.383
D89.3 Immune reconstitution syndrome
0.000 0.618 0.381
E79 Disorders of purine and pyrimidine metabolism
0.000 0.619 0.381
D69.1 Qualitative platelet defects
0.000 0.621 0.379
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.622 0.377
D55.8 Other anaemias due to enzyme disorders
0.000 0.622 0.377
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.622 0.377
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.622 0.377
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.622 0.377
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.622 0.377
E70 Disorders of aromatic amino-acid metabolism
0.000 0.624 0.376
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.632 0.367
D89.1 Cryoglobulinaemia
0.000 0.633 0.367
E20 Hypoparathyroidism
0.000 0.633 0.367
E77 Disorders of glycoprotein metabolism
0.000 0.637 0.362
E76 Disorders of glycosaminoglycan metabolism
0.000 0.637 0.362
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.637 0.362
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.637 0.362
D50.9 Iron deficiency anaemia, unspecified
0.000 0.639 0.361
D57.8 Other sickle-cell disorders
0.000 0.640 0.360
D57.3 Sickle-cell trait
0.000 0.640 0.360
D57.2 Double heterozygous sickling disorders
0.000 0.640 0.360
D57.0 Sickle-cell anaemia with crisis
0.000 0.640 0.360
E88.9 Metabolic disorder, unspecified
0.000 0.642 0.358
K90.9 Intestinal malabsorption, unspecified
0.000 0.642 0.358
E83.8 Other disorders of mineral metabolism
0.000 0.645 0.355
E83.2 Disorders of zinc metabolism
0.000 0.645 0.355
E83.0 Disorders of copper metabolism
0.000 0.645 0.355
D69.4 Other primary thrombocytopenia
0.000 0.647 0.353
E44.1 Mild protein-energy malnutrition
0.000 0.647 0.352
E44.0 Moderate protein-energy malnutrition
0.000 0.647 0.352
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.648 0.352
E66 Obesity
0.000 0.650 0.350
E25 Adrenogenital disorders
0.000 0.653 0.346
E34.9 Endocrine disorder, unspecified
0.000 0.654 0.346
D58.2 Other haemoglobinopathies
0.000 0.655 0.345
E85.3 Secondary systemic amyloidosis
0.000 0.655 0.345
E56.1 Deficiency of vitamin K
0.000 0.658 0.341
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.659 0.340
E84 Cystic fibrosis
0.000 0.661 0.339
D50.1 Sideropenic dysphagia
0.000 0.662 0.337
D50.8 Other iron deficiency anaemias
0.000 0.664 0.336
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.664 0.335
E32 Diseases of thymus
0.000 0.664 0.335
E31 Polyglandular dysfunction
0.000 0.664 0.335
E30 Disorders of puberty, not elsewhere classified
0.000 0.664 0.335
D57.1 Sickle-cell anaemia without crisis
0.000 0.665 0.335
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.665 0.334
D58.1 Hereditary elliptocytosis
0.000 0.665 0.334
E72 Other disorders of amino-acid metabolism
0.000 0.667 0.333
D56 Thalassaemia
0.001 0.667 0.331
E27.5 Adrenomedullary hyperfunction
0.000 0.671 0.329
E27.0 Other adrenocortical overactivity
0.000 0.671 0.329
E85.8 Other amyloidosis
0.000 0.674 0.326
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.674 0.326
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.674 0.326
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.674 0.326
E88.3 Tumour lysis syndrome
0.000 0.674 0.326
E27.2 Addisonian crisis
0.000 0.675 0.325
K90.3 Pancreatic steatorrhoea
0.000 0.681 0.319
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.681 0.319
K90.1 Tropical sprue
0.000 0.681 0.319
E85.9 Amyloidosis, unspecified
0.000 0.686 0.314
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.686 0.313
D52.8 Other folate deficiency anaemias
0.000 0.687 0.313
D52.1 Drug-induced folate deficiency anaemia
0.000 0.687 0.313
D52.0 Dietary folate deficiency anaemia
0.000 0.687 0.313
E34.0 Carcinoid syndrome
0.000 0.687 0.313
E88.8 Other specified metabolic disorders
0.000 0.690 0.310
E74 Other disorders of carbohydrate metabolism
0.000 0.691 0.309
K90.8 Other intestinal malabsorption
0.000 0.692 0.307
E61.9 Deficiency of nutrient element, unspecified
0.000 0.693 0.306
E61.8 Deficiency of other specified nutrient elements
0.000 0.693 0.306
E61.7 Deficiency of multiple nutrient elements
0.000 0.693 0.306
E61.6 Vanadium deficiency
0.000 0.693 0.306
E61.5 Molybdenum deficiency
0.000 0.693 0.306
E61.4 Chromium deficiency
0.000 0.693 0.306
E61.3 Manganese deficiency
0.000 0.693 0.306
E61.0 Copper deficiency
0.000 0.693 0.306
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.695 0.305
E27.8 Other specified disorders of adrenal gland
0.000 0.699 0.301
E66.0 Obesity due to excess calories
0.000 0.700 0.300
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.702 0.298
E04.1 Non-toxic single thyroid nodule
0.000 0.704 0.295
D58.0 Hereditary spherocytosis
0.000 0.705 0.295
E20.9 Hypoparathyroidism, unspecified
0.000 0.706 0.294
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.708 0.292
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.708 0.291
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.713 0.287
E70.3 Albinism
0.000 0.716 0.284
E73 Lactose intolerance
0.000 0.717 0.283
E22 Hyperfunction of pituitary gland
0.000 0.718 0.282
E34.5 Androgen resistance syndrome
0.000 0.719 0.281
E34.4 Constitutional tall stature
0.000 0.719 0.281
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.719 0.281
E34.1 Other hypersecretion of intestinal hormones
0.000 0.719 0.281
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.720 0.280
E24 Cushing's syndrome
0.000 0.720 0.280
E88.2 Lipomatosis, not elsewhere classified
0.000 0.721 0.279
E67.8 Other specified hyperalimentation
0.000 0.725 0.275
E67.3 Hypervitaminosis D
0.000 0.725 0.275
E67.2 Megavitamin-B6 syndrome
0.000 0.725 0.275
E67.1 Hypercarotenaemia
0.000 0.725 0.275
E67.0 Hypervitaminosis A
0.000 0.725 0.275
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.727 0.273
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.727 0.273
E79.1 Lesch-Nyhan syndrome
0.000 0.727 0.273
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.730 0.270
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.730 0.270
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.730 0.270
E70.2 Disorders of tyrosine metabolism
0.000 0.730 0.270
E70.1 Other hyperphenylalaninaemias
0.000 0.730 0.270
E70.0 Classical phenylketonuria
0.000 0.730 0.270
E29 Testicular dysfunction
0.000 0.730 0.270
E34.3 Short stature, not elsewhere classified
0.000 0.730 0.269
E61.2 Magnesium deficiency
0.000 0.731 0.269
E86 Volume depletion
0.000 0.735 0.265
E20.8 Other hypoparathyroidism
0.000 0.737 0.263
E20.1 Pseudohypoparathyroidism
0.000 0.737 0.263
E20.0 Idiopathic hypoparathyroidism
0.000 0.737 0.263
D60-D64 Aplastic and other anaemias
0.000 0.737 0.263
S64.4 Injury of digital nerve of other finger
0.263 0.737 0.000
E65 Localised adiposity
0.000 0.739 0.261
E71.3 Disorders of fatty-acid metabolism
0.000 0.740 0.260
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.740 0.260
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.740 0.260
E71.0 Maple-syrup-urine disease
0.000 0.740 0.260
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.740 0.260
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.740 0.260
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.740 0.260
E76.2 Other mucopolysaccharidoses
0.000 0.740 0.260
E76.1 Mucopolysaccharidosis, type II
0.000 0.740 0.260
E76.0 Mucopolysaccharidosis, type I
0.000 0.740 0.260
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.740 0.260
E77.8 Other disorders of glycoprotein metabolism
0.000 0.740 0.260
E77.1 Defects in glycoprotein degradation
0.000 0.740 0.260
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.740 0.260
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.740 0.259
E66.1 Drug-induced obesity
0.000 0.749 0.251
E25.9 Adrenogenital disorder, unspecified
0.000 0.751 0.248
E25.8 Other adrenogenital disorders
0.000 0.751 0.248
D73 Diseases of spleen
0.000 0.752 0.247
E84.8 Cystic fibrosis with other manifestations
0.000 0.756 0.243
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.756 0.243
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.756 0.243
E30.9 Disorder of puberty, unspecified
0.000 0.759 0.241
E30.8 Other disorders of puberty
0.000 0.759 0.241
E30.1 Precocious puberty
0.000 0.759 0.241
E30.0 Delayed puberty
0.000 0.759 0.241
E31.9 Polyglandular dysfunction, unspecified
0.000 0.759 0.241
E31.8 Other polyglandular dysfunction
0.000 0.759 0.241
E31.1 Polyglandular hyperfunction
0.000 0.759 0.241
E31.0 Autoimmune polyglandular failure
0.000 0.759 0.241
E32.9 Disease of thymus, unspecified
0.000 0.759 0.241
E32.8 Other diseases of thymus
0.000 0.759 0.241
E32.1 Abscess of thymus
0.000 0.759 0.241
E32.0 Persistent hyperplasia of thymus
0.000 0.759 0.241
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.759 0.241
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.759 0.241
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.759 0.241
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.761 0.239
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.761 0.239
E72.5 Disorders of glycine metabolism
0.000 0.761 0.239
E72.4 Disorders of ornithine metabolism
0.000 0.761 0.239
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.761 0.239
E72.2 Disorders of urea cycle metabolism
0.000 0.761 0.239
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.761 0.239
D56.9 Thalassaemia, unspecified
0.001 0.761 0.238
D56.8 Other thalassaemias
0.001 0.761 0.238
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.761 0.238
D56.2 Delta-beta thalassaemia
0.001 0.761 0.238
D56.0 Alpha thalassaemia
0.001 0.761 0.238
E26 Hyperaldosteronism
0.000 0.766 0.233
D84.9 Immunodeficiency, unspecified
0.001 0.772 0.226
E22.1 Hyperprolactinaemia
0.000 0.774 0.226
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.778 0.221
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.778 0.221
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.778 0.221
E74.2 Disorders of galactose metabolism
0.000 0.778 0.221
E74.1 Disorders of fructose metabolism
0.000 0.778 0.221
E74.0 Glycogen storage disease
0.000 0.778 0.221
E34.8 Other specified endocrine disorders
0.000 0.780 0.220
E84.9 Cystic fibrosis, unspecified
0.000 0.780 0.220
E24.0 Pituitary-dependent Cushing's disease
0.000 0.783 0.217
E27.9 Disorder of adrenal gland, unspecified
0.000 0.789 0.211
E75.6 Lipid storage disorder, unspecified
0.000 0.791 0.209
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.791 0.209
E75.3 Sphingolipidosis, unspecified
0.000 0.791 0.209
E75.1 Other gangliosidosis
0.000 0.791 0.209
E75.0 GM2 gangliosidosis
0.000 0.791 0.209
E72.0 Disorders of amino-acid transport
0.000 0.791 0.209
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.793 0.206

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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