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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523590
log Bayes Factor = 74.922
Chromosome 6   position 31,327,064  (GRCh37) Explore rs2523590 on Ensembl!
Variant rs2523590 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
M45 Ankylosing spondylitis
0.999 0.001 0.000
E50-E64 Other nutritional deficiencies
0.000 0.002 0.998
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.996 0.004 0.000
L40 Psoriasis
0.996 0.004 0.000
L40.5 Arthropathic psoriasis
0.993 0.007 0.000
E10.3 With ophthalmic complications
0.000 0.010 0.990
E06 Thyroiditis
0.000 0.013 0.987
E10.9 Without complications
0.000 0.015 0.985
E53 Deficiency of other B group vitamins
0.000 0.018 0.982
E40-E46 Malnutrition
0.000 0.030 0.970
M45.X2 Ankylosing spondylitis (Cervical region)
0.970 0.030 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.031 0.969
E06.3 Autoimmune thyroiditis
0.000 0.034 0.966
E10.2 With renal complications
0.000 0.039 0.961
E55 Vitamin D deficiency
0.000 0.044 0.956
E46 Unspecified protein-energy malnutrition
0.000 0.051 0.949
E55.9 Vitamin D deficiency, unspecified
0.000 0.074 0.926
L40.8 Other psoriasis
0.891 0.109 0.000
E10.1 With ketoacidosis
0.000 0.112 0.888
E10.4 With neurological complications
0.000 0.119 0.881
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.139 0.861
E06.9 Thyroiditis, unspecified
0.000 0.139 0.861
E65-E68 Obesity and other hyperalimentation
0.000 0.139 0.861
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.163 0.837
G37 Other demyelinating diseases of central nervous system
0.000 0.171 0.829
K90 Intestinal malabsorption
0.000 0.179 0.821
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.820 0.180 0.000
E61 Deficiency of other nutrient elements
0.000 0.182 0.818
E03 Other hypothyroidism
0.000 0.204 0.796
E10.5 With peripheral circulatory complications
0.000 0.204 0.796
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.205 0.795
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.228 0.772
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.230 0.770
L40.1 Generalised pustular psoriasis
0.763 0.237 0.000
E51 Thiamine deficiency
0.000 0.241 0.759
E10.0 With coma
0.000 0.243 0.757
E10.8 With unspecified complications
0.000 0.247 0.753
M45.X6 Ankylosing spondylitis (Lumbar region)
0.750 0.250 0.000
E05.8 Other thyrotoxicosis
0.000 0.266 0.734
E20-E35 Disorders of other endocrine glands
0.000 0.269 0.731
E03.9 Hypothyroidism, unspecified
0.000 0.273 0.727
E53.9 Vitamin B deficiency, unspecified
0.000 0.274 0.726
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.279 0.721
E66 Obesity
0.000 0.279 0.721
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.717 0.283 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.717 0.283 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.717 0.283 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.717 0.283 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.717 0.283 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.284 0.715
E63 Other nutritional deficiencies
0.000 0.284 0.715
E50 Vitamin A deficiency
0.000 0.284 0.715
E60 Dietary zinc deficiency
0.000 0.284 0.715
E59 Dietary selenium deficiency
0.000 0.284 0.715
E54 Ascorbic acid deficiency
0.000 0.284 0.715
E52 Niacin deficiency [pellagra]
0.000 0.284 0.715
L40.2 Acrodermatitis continua
0.714 0.286 0.000
E56 Other vitamin deficiencies
0.000 0.287 0.713
E14 Unspecified diabetes mellitus
0.000 0.290 0.710
L40.4 Guttate psoriasis
0.709 0.291 0.000
E06.4 Drug-induced thyroiditis
0.000 0.293 0.707
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.293 0.707
E06.1 Subacute thyroiditis
0.000 0.293 0.707
E06.0 Acute thyroiditis
0.000 0.293 0.707
K90.9 Intestinal malabsorption, unspecified
0.000 0.293 0.707
E10.6 With other specified complications
0.000 0.295 0.705
E53.1 Pyridoxine deficiency
0.000 0.296 0.704
E53.0 Riboflavin deficiency
0.000 0.296 0.704
E06.5 Other chronic thyroiditis
0.000 0.297 0.703
E66.8 Other obesity
0.000 0.299 0.701
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.304 0.696
E45 Retarded development following protein-energy malnutrition
0.000 0.304 0.696
E43 Unspecified severe protein-energy malnutrition
0.000 0.304 0.696
E42 Marasmic kwashiorkor
0.000 0.304 0.696
E41 Nutritional marasmus
0.000 0.304 0.696
E40 Kwashiorkor
0.000 0.304 0.696
E27 Other disorders of adrenal gland
0.000 0.307 0.693
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.309 0.691
E58 Dietary calcium deficiency
0.000 0.310 0.690
E65 Localised adiposity
0.000 0.313 0.686
E55.0 Rickets, active
0.000 0.314 0.685
K90.8 Other intestinal malabsorption
0.000 0.319 0.680
L40.3 Pustulosis palmaris et plantaris
0.670 0.330 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.337 0.663
E61.1 Iron deficiency
0.000 0.352 0.648
E16 Other disorders of pancreatic internal secretion
0.000 0.353 0.647
G36 Other acute disseminated demyelination
0.000 0.355 0.644
E61.2 Magnesium deficiency
0.000 0.358 0.642
E89.0 Postprocedural hypothyroidism
0.000 0.365 0.635
E14.8 With unspecified complications
0.000 0.370 0.630
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.375 0.625
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.375 0.625
E13 Other specified diabetes mellitus
0.000 0.379 0.621
E70-E90 Metabolic disorders
0.000 0.380 0.620
E67 Other hyperalimentation
0.000 0.383 0.617
E68 Sequelae of hyperalimentation
0.000 0.383 0.617
E20 Hypoparathyroidism
0.000 0.402 0.598
G37.5 Concentric sclerosis [Balo]
0.000 0.405 0.594
G37.4 Subacute necrotising myelitis
0.000 0.405 0.594
G37.2 Central pontine myelinolysis
0.000 0.405 0.594
G37.1 Central demyelination of corpus callosum
0.000 0.405 0.594
G37.0 Diffuse sclerosis
0.000 0.405 0.594
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.409 0.591
K90.3 Pancreatic steatorrhoea
0.000 0.411 0.589
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.411 0.589
K90.1 Tropical sprue
0.000 0.411 0.589
E51.2 Wernicke's encephalopathy
0.000 0.412 0.587
E61.9 Deficiency of nutrient element, unspecified
0.000 0.413 0.586
E61.8 Deficiency of other specified nutrient elements
0.000 0.413 0.586
E61.7 Deficiency of multiple nutrient elements
0.000 0.413 0.586
E61.6 Vanadium deficiency
0.000 0.413 0.586
E61.5 Molybdenum deficiency
0.000 0.413 0.586
E61.4 Chromium deficiency
0.000 0.413 0.586
E61.3 Manganese deficiency
0.000 0.413 0.586
E61.0 Copper deficiency
0.000 0.413 0.586
E22 Hyperfunction of pituitary gland
0.000 0.420 0.580
E03.5 Myxoedema coma
0.000 0.429 0.571
E03.4 Atrophy of thyroid (acquired)
0.000 0.429 0.571
E03.3 Postinfectious hypothyroidism
0.000 0.429 0.571
E15 Nondiabetic hypoglycaemic coma
0.000 0.430 0.570
E03.1 Congenital hypothyroidism without goitre
0.000 0.431 0.568
E14.6 With other specified complications
0.000 0.442 0.557
E03.8 Other specified hypothyroidism
0.000 0.445 0.555
E27.8 Other specified disorders of adrenal gland
0.000 0.449 0.550
E51.9 Thiamine deficiency, unspecified
0.000 0.456 0.544
E51.8 Other manifestations of thiamine deficiency
0.000 0.456 0.544
E51.1 Beriberi
0.000 0.456 0.544
E14.2 Withrenal complications
0.000 0.458 0.542
E25 Adrenogenital disorders
0.000 0.459 0.541
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.459 0.541
E34 Other endocrine disorders
0.000 0.464 0.536
L40.0 Psoriasis vulgaris
0.535 0.465 0.000
E27.2 Addisonian crisis
0.000 0.468 0.532
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.476 0.524
E32 Diseases of thymus
0.000 0.476 0.524
E31 Polyglandular dysfunction
0.000 0.476 0.524
E30 Disorders of puberty, not elsewhere classified
0.000 0.476 0.524
E83 Disorders of mineral metabolism
0.000 0.479 0.521
E14.3 With ophthalmic complications
0.000 0.482 0.518
E66.1 Drug-induced obesity
0.000 0.483 0.517
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.484 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E50.9 Vitamin A deficiency, unspecified
0.000 0.487 0.513
E50.8 Other manifestations of vitamin A deficiency
0.000 0.487 0.513
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.487 0.513
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.487 0.513
E50.5 Vitamin A deficiency with night blindness
0.000 0.487 0.513
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.487 0.513
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.487 0.513
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.487 0.513
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.487 0.513
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.487 0.513
E63.9 Nutritional deficiency, unspecified
0.000 0.487 0.513
E63.8 Other specified nutritional deficiencies
0.000 0.487 0.513
E63.1 Imbalance of constituents of food intake
0.000 0.487 0.513
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.487 0.513
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.487 0.513
E64.8 Sequelae of other nutritional deficiencies
0.000 0.487 0.513
E64.3 Sequelae of rickets
0.000 0.487 0.513
E64.2 Sequelae of vitamin C deficiency
0.000 0.487 0.513
E64.1 Sequelae of vitamin A deficiency
0.000 0.487 0.513
E64.0 Sequelae of protein-energy malnutrition
0.000 0.487 0.513
E56.9 Vitamin deficiency, unspecified
0.000 0.489 0.511
E56.8 Deficiency of other vitamins
0.000 0.489 0.511
E56.0 Deficiency of vitamin E
0.000 0.489 0.511
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.490 0.510
E14.7 With multiple complications
0.000 0.491 0.509
E14.0 With coma
0.000 0.491 0.509
E56.1 Deficiency of vitamin K
0.000 0.492 0.508
E22.0 Acromegaly and pituitary gigantism
0.000 0.492 0.508
E83.1 Disorders of iron metabolism
0.000 0.494 0.506
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.495 0.505
E79 Disorders of purine and pyrimidine metabolism
0.000 0.497 0.503
E14.1 With ketoacidosis
0.000 0.497 0.503
E20.9 Hypoparathyroidism, unspecified
0.000 0.498 0.502
L40-L45 Papulosquamous disorders
0.502 0.498 0.000
E07 Other disorders of thyroid
0.000 0.500 0.500
E44.1 Mild protein-energy malnutrition
0.000 0.501 0.499
E44.0 Moderate protein-energy malnutrition
0.000 0.501 0.499
E27.5 Adrenomedullary hyperfunction
0.000 0.503 0.497
E27.0 Other adrenocortical overactivity
0.000 0.503 0.497
E89.2 Postprocedural hypoparathyroidism
0.000 0.509 0.491
M45-M49 Spondylopathies
0.491 0.509 0.000
G36.0 Neuromyelitis optica [Devic]
0.000 0.510 0.489
E26 Hyperaldosteronism
0.000 0.512 0.488
E14.5 With peripheral circulatory complications
0.000 0.514 0.486
E22.1 Hyperprolactinaemia
0.000 0.517 0.483
E73 Lactose intolerance
0.000 0.521 0.479
E16.2 Hypoglycaemia, unspecified
0.000 0.533 0.467
E29 Testicular dysfunction
0.000 0.533 0.467
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.536 0.464
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.536 0.464
E16.4 Abnormal secretion of gastrin
0.000 0.536 0.464
E16.3 Increased secretion of glucagon
0.000 0.536 0.464
G36.9 Acute disseminated demyelination, unspecified
0.000 0.538 0.462
G36.8 Other specified acute disseminated demyelination
0.000 0.538 0.462
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.538 0.462
M46 Other inflammatory spondylopathies
0.459 0.541 0.000
L42 Pityriasis rosea
0.455 0.545 0.000
E89.3 Postprocedural hypopituitarism
0.000 0.546 0.454
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.552 0.448
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.552 0.448
E89.5 Postprocedural testicular hypofunction
0.000 0.552 0.448
E89.1 Postprocedural hypoinsulinaemia
0.000 0.552 0.448
E13.8 With unspecified complications
0.000 0.554 0.445
E13.7 With multiple complications
0.000 0.554 0.445
E13.6 With other specified complications
0.000 0.554 0.445
E13.5 With peripheral circulatory complications
0.000 0.554 0.445
E13.4 With neurological complications
0.000 0.554 0.445
E13.3 With ophthalmic complications
0.000 0.554 0.445
E13.2 With renal complications
0.000 0.554 0.445
E13.1 With ketoacidosis
0.000 0.554 0.445
E13.0 With coma
0.000 0.554 0.445
E77 Disorders of glycoprotein metabolism
0.000 0.555 0.445
E76 Disorders of glycosaminoglycan metabolism
0.000 0.555 0.445
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.555 0.445
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.555 0.445
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.557 0.443
E67.8 Other specified hyperalimentation
0.000 0.557 0.442
E67.3 Hypervitaminosis D
0.000 0.557 0.442
E67.2 Megavitamin-B6 syndrome
0.000 0.557 0.442
E67.1 Hypercarotenaemia
0.000 0.557 0.442
E67.0 Hypervitaminosis A
0.000 0.557 0.442
E70 Disorders of aromatic amino-acid metabolism
0.000 0.559 0.441
E72 Other disorders of amino-acid metabolism
0.000 0.562 0.438
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.564 0.436
E21.0 Primary hyperparathyroidism
0.000 0.566 0.434
E84 Cystic fibrosis
0.000 0.571 0.429
E20.8 Other hypoparathyroidism
0.000 0.571 0.428
E20.1 Pseudohypoparathyroidism
0.000 0.571 0.428
E20.0 Idiopathic hypoparathyroidism
0.000 0.571 0.428
E74 Other disorders of carbohydrate metabolism
0.000 0.573 0.427
M46.9 Inflammatory spondylopathy, unspecified
0.424 0.576 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.577 0.423
E66.0 Obesity due to excess calories
0.000 0.578 0.421
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.581 0.419
E27.9 Disorder of adrenal gland, unspecified
0.000 0.583 0.416
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.584 0.416
E22.8 Other hyperfunction of pituitary gland
0.000 0.584 0.416
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.588 0.412
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)
0.410 0.590 0.000
E34.8 Other specified endocrine disorders
0.000 0.592 0.408
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.596 0.404
M46.4 Discitis, unspecified
0.390 0.610 0.000
E14.4 With neurological complications
0.000 0.611 0.389
E34.9 Endocrine disorder, unspecified
0.000 0.612 0.388
E25.9 Adrenogenital disorder, unspecified
0.000 0.612 0.388
E25.8 Other adrenogenital disorders
0.000 0.612 0.388
E34.5 Androgen resistance syndrome
0.000 0.616 0.384
E34.4 Constitutional tall stature
0.000 0.616 0.384
E34.3 Short stature, not elsewhere classified
0.000 0.616 0.384
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.616 0.384
E34.1 Other hypersecretion of intestinal hormones
0.000 0.616 0.384
M49 Spondylopathies in diseases classified elsewhere
0.378 0.622 0.000
E73.9 Lactose intolerance, unspecified
0.000 0.622 0.378
L44 Other papulosquamous disorders
0.376 0.624 0.000
E30.9 Disorder of puberty, unspecified
0.000 0.624 0.376
E30.8 Other disorders of puberty
0.000 0.624 0.376
E30.1 Precocious puberty
0.000 0.624 0.376
E30.0 Delayed puberty
0.000 0.624 0.376
E31.9 Polyglandular dysfunction, unspecified
0.000 0.624 0.376
E31.8 Other polyglandular dysfunction
0.000 0.624 0.376
E31.1 Polyglandular hyperfunction
0.000 0.624 0.376
E31.0 Autoimmune polyglandular failure
0.000 0.624 0.376
E32.9 Disease of thymus, unspecified
0.000 0.624 0.376
E32.8 Other diseases of thymus
0.000 0.624 0.376
E32.1 Abscess of thymus
0.000 0.624 0.376
E32.0 Persistent hyperplasia of thymus
0.000 0.624 0.376
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.624 0.376
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.624 0.376
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.624 0.376
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.626 0.374
E83.8 Other disorders of mineral metabolism
0.000 0.626 0.374
E83.2 Disorders of zinc metabolism
0.000 0.626 0.374
E83.0 Disorders of copper metabolism
0.000 0.626 0.374
E89.4 Postprocedural ovarian failure
0.000 0.629 0.371
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.633 0.367
E34.0 Carcinoid syndrome
0.000 0.634 0.366
E21.4 Other specified disorders of parathyroid gland
0.000 0.634 0.366
E21.2 Other hyperparathyroidism
0.000 0.634 0.366
E28 Ovarian dysfunction
0.000 0.635 0.365
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.639 0.361
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.639 0.361
E79.1 Lesch-Nyhan syndrome
0.000 0.639 0.361
L41 Parapsoriasis
0.360 0.640 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.360 0.640 0.000
E07.1 Dyshormogenetic goitre
0.000 0.642 0.358
E07.0 Hypersecretion of calcitonin
0.000 0.642 0.358
E83.4 Disorders of magnesium metabolism
0.000 0.648 0.352
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.649 0.351
E26.9 Hyperaldosteronism, unspecified
0.000 0.650 0.350
E26.8 Other hyperaldosteronism
0.000 0.650 0.350
E26.1 Secondary hyperaldosteronism
0.000 0.650 0.350
E13.9 Without complications
0.000 0.650 0.350
E73.8 Other lactose intolerance
0.000 0.656 0.343
E73.1 Secondary lactase deficiency
0.000 0.656 0.343
E73.0 Congenital lactase deficiency
0.000 0.656 0.343
M46.46 Discitis, unspecified (Lumbar region)
0.342 0.658 0.000
E24 Cushing's syndrome
0.000 0.662 0.338
E29.9 Testicular dysfunction, unspecified
0.000 0.665 0.335
E29.8 Other testicular dysfunction
0.000 0.665 0.335
E29.0 Testicular hyperfunction
0.000 0.665 0.335
M46.0 Spinal enthesopathy
0.334 0.666 0.000
M46.8 Other specified inflammatory spondylopathies
0.329 0.671 0.000
M46.5 Other infective spondylopathies
0.329 0.671 0.000
M46.2 Osteomyelitis of vertebra
0.328 0.672 0.000
E07.8 Other specified disorders of thyroid
0.000 0.673 0.326
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)
0.326 0.674 0.000
E71.3 Disorders of fatty-acid metabolism
0.000 0.681 0.319
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.681 0.319
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.681 0.319
E71.0 Maple-syrup-urine disease
0.000 0.681 0.319
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.681 0.319
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.681 0.319
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.681 0.319
E76.2 Other mucopolysaccharidoses
0.000 0.681 0.319
E76.1 Mucopolysaccharidosis, type II
0.000 0.681 0.319
E76.0 Mucopolysaccharidosis, type I
0.000 0.681 0.319
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.681 0.319
E77.8 Other disorders of glycoprotein metabolism
0.000 0.681 0.319
E77.1 Defects in glycoprotein degradation
0.000 0.681 0.319
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.681 0.319
M46.3 Infection of intervertebral disk (pyogenic)
0.319 0.681 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.684 0.316
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.684 0.316
E70.2 Disorders of tyrosine metabolism
0.000 0.684 0.316
E70.1 Other hyperphenylalaninaemias
0.000 0.684 0.316
E70.0 Classical phenylketonuria
0.000 0.684 0.316
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.686 0.314
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.686 0.314
E72.5 Disorders of glycine metabolism
0.000 0.686 0.314
E72.4 Disorders of ornithine metabolism
0.000 0.686 0.314
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.686 0.314
E72.2 Disorders of urea cycle metabolism
0.000 0.686 0.314
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.686 0.314
E26.0 Primary hyperaldosteronism
0.000 0.686 0.314
E70.3 Albinism
0.000 0.688 0.312
M46.1 Sacro-iliitis, not elsewhere classified
0.310 0.689 0.000
E84.8 Cystic fibrosis with other manifestations
0.000 0.692 0.307
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.692 0.307
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.692 0.307
E72.0 Disorders of amino-acid transport
0.000 0.693 0.307
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.694 0.306
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.694 0.306
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.694 0.306
E74.2 Disorders of galactose metabolism
0.000 0.694 0.306
E74.1 Disorders of fructose metabolism
0.000 0.694 0.306
E74.0 Glycogen storage disease
0.000 0.694 0.306
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)
0.304 0.696 0.000
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)
0.304 0.696 0.000
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)
0.304 0.696 0.000
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)
0.304 0.696 0.000
E16.1 Other hypoglycaemia
0.001 0.697 0.302
M49.5 Collapsed vertebra in diseases classified elsewhere
0.298 0.702 0.000
E84.9 Cystic fibrosis, unspecified
0.000 0.709 0.291
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)
0.289 0.711 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.712 0.288
E83.5 Disorders of calcium metabolism
0.000 0.713 0.287
L44.0 Pityriasis rubra pilaris
0.286 0.714 0.000
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)
0.285 0.714 0.000
M46.49 Discitis, unspecified (Site unspecified)
0.280 0.720 0.000
M46.48 Discitis, unspecified (Sacral and sacrococcygeal region)
0.280 0.720 0.000
M46.47 Discitis, unspecified (Lumbosacral region)
0.280 0.720 0.000
M46.45 Discitis, unspecified (Thoracolumbar region)
0.280 0.720 0.000
M46.43 Discitis, unspecified (Cervicothoracic region)
0.280 0.720 0.000
M46.42 Discitis, unspecified (Cervical region)
0.280 0.720 0.000
M46.41 Discitis, unspecified (Occipito-atlanto-axial region)
0.280 0.720 0.000
M46.40 Discitis, unspecified (Multiple sites in spine)
0.280 0.720 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.721 0.279
E29.1 Testicular hypofunction
0.000 0.722 0.278
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)
0.277 0.723 0.000
M46.44 Discitis, unspecified (Thoracic region)
0.277 0.723 0.000
E28.3 Primary ovarian failure
0.000 0.727 0.273
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)
0.273 0.727 0.000
M49.8 Spondylopathy in other diseases classified elsewhere
0.271 0.728 0.000
M49.4 Neuropathic spondylopathy
0.271 0.728 0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.271 0.728 0.000
M49.2 Enterobacterial spondylitis
0.271 0.728 0.000
M49.1 Brucella spondylitis
0.271 0.728 0.000
M49.0 Tuberculosis of spine
0.271 0.728 0.000
L44.9 Papulosquamous disorder, unspecified
0.270 0.730 0.000
L44.8 Other specified papulosquamous disorders
0.270 0.730 0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.270 0.730 0.000
L44.3 Lichen ruber moniliformis
0.270 0.730 0.000
L44.2 Lichen striatus
0.270 0.730 0.000
L44.1 Lichen nitidus
0.270 0.730 0.000
E88 Other metabolic disorders
0.000 0.734 0.265
E75.6 Lipid storage disorder, unspecified
0.000 0.737 0.263
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.737 0.263
E75.3 Sphingolipidosis, unspecified
0.000 0.737 0.263
E75.1 Other gangliosidosis
0.000 0.737 0.263
E75.0 GM2 gangliosidosis
0.000 0.737 0.263
E04 Other non-toxic goitre
0.000 0.738 0.262
E28.9 Ovarian dysfunction, unspecified
0.000 0.738 0.262
E28.8 Other ovarian dysfunction
0.000 0.738 0.262
E28.1 Androgen excess
0.000 0.738 0.262
E28.0 Oestrogen excess
0.000 0.738 0.262
L41.9 Parapsoriasis, unspecified
0.258 0.742 0.000
L41.8 Other parapsoriasis
0.258 0.742 0.000
L41.5 Retiform parapsoriasis
0.258 0.742 0.000
L41.4 Large plaque parapsoriasis
0.258 0.742 0.000
L41.3 Small plaque parapsoriasis
0.258 0.742 0.000
L41.2 Lymphomatoid papulosis
0.258 0.742 0.000
L41.1 Pityriasis lichenoides chronica
0.258 0.742 0.000
L41.0 Pityriasis lichenoides et varioliformis acuta
0.258 0.742 0.000
E80.1 Porphyria cutanea tarda
0.000 0.743 0.256
E80.6 Other disorders of bilirubin metabolism
0.000 0.745 0.255
E23 Hypofunction and other disorders of pituitary gland
0.000 0.745 0.255
E75.5 Other lipid storage disorders
0.000 0.746 0.253
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)
0.253 0.747 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.748 0.252
E80.5 Crigler-Najjar syndrome
0.000 0.748 0.252
E80.3 Defects of catalase and peroxydase
0.000 0.748 0.252
E80.0 Hereditary erythropoietic porphyria
0.000 0.748 0.252
M48 Other spondylopathies
0.250 0.750 0.000
M46.19 Sacroiliitis, not elsewhere classified-Site unspe
0.247 0.753 0.000
M46.06 Spinal enthesopathy (Lumbar region)
0.244 0.756 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.757 0.242
E24.3 Ectopic ACTH syndrome
0.000 0.757 0.242
E24.1 Nelson's syndrome
0.000 0.757 0.242
E24.0 Pituitary-dependent Cushing's disease
0.000 0.760 0.240
M46.34 Infection of intervertebral disc (pyogenic) (Thoracic region)
0.240 0.760 0.000
M46.09 Spinal enthesopathy (Site unspecified)
0.239 0.760 0.000
M46.08 Spinal enthesopathy (Sacral and sacrococcygeal region)
0.239 0.760 0.000
M46.07 Spinal enthesopathy (Lumbosacral region)
0.239 0.760 0.000
M46.05 Spinal enthesopathy (Thoracolumbar region)
0.239 0.760 0.000
M46.04 Spinal enthesopathy (Thoracic region)
0.239 0.760 0.000
M46.03 Spinal enthesopathy (Cervicothoracic region)
0.239 0.760 0.000
M46.02 Spinal enthesopathy (Cervical region)
0.239 0.760 0.000
M46.01 Spinal enthesopathy (Occipito-atlanto-axial region)
0.239 0.760 0.000
M46.00 Spinal enthesopathy (Multiple sites in spine)
0.239 0.760 0.000
M46.59 Other infective spondylopathies (Site unspecified)
0.236 0.764 0.000
M46.58 Other infective spondylopathies (Sacral and sacrococcygeal region)
0.236 0.764 0.000
M46.57 Other infective spondylopathies (Lumbosacral region)
0.236 0.764 0.000
M46.56 Other infective spondylopathies (Lumbar region)
0.236 0.764 0.000
M46.55 Other infective spondylopathies (Thoracolumbar region)
0.236 0.764 0.000
M46.54 Other infective spondylopathies (Thoracic region)
0.236 0.764 0.000
M46.53 Other infective spondylopathies (Cervicothoracic region)
0.236 0.764 0.000
M46.52 Other infective spondylopathies (Cervical region)
0.236 0.764 0.000
M46.51 Other infective spondylopathies (Occipito-atlanto-axial region)
0.236 0.764 0.000
M46.50 Other infective spondylopathies (Multiple sites in spine)
0.236 0.764 0.000
M46.89 Other specified inflammatory spondylopathies (Site unspecified)
0.236 0.764 0.000
M46.88 Other specified inflammatory spondylopathies (Sacral and sacrococcygeal region)
0.236 0.764 0.000
M46.87 Other specified inflammatory spondylopathies (Lumbosacral region)
0.236 0.764 0.000
M46.86 Other specified inflammatory spondylopathies (Lumbar region)
0.236 0.764 0.000
M46.85 Other specified inflammatory spondylopathies (Thoracolumbar region)
0.236 0.764 0.000
M46.84 Other specified inflammatory spondylopathies (Thoracic region)
0.236 0.764 0.000
M46.83 Other specified inflammatory spondylopathies (Cervicothoracic region)
0.236 0.764 0.000
M46.82 Other specified inflammatory spondylopathies (Cervical region)
0.236 0.764 0.000
M46.81 Other specified inflammatory spondylopathies (Occipito-atlanto-axial region)
0.236 0.764 0.000
M46.80 Other specified inflammatory spondylopathies (Multiple sites in spine)
0.236 0.764 0.000
M46.29 Osteomyelitis of vertebra (Site unspecified)
0.235 0.765 0.000
M46.28 Osteomyelitis of vertebra (Sacral and sacrococcygeal region)
0.235 0.765 0.000
M46.27 Osteomyelitis of vertebra (Lumbosacral region)
0.235 0.765 0.000
M46.25 Osteomyelitis of vertebra (Thoracolumbar region)
0.235 0.765 0.000
M46.24 Osteomyelitis of vertebra (Thoracic region)
0.235 0.765 0.000
M46.23 Osteomyelitis of vertebra (Cervicothoracic region)
0.235 0.765 0.000
M46.22 Osteomyelitis of vertebra (Cervical region)
0.235 0.765 0.000
M46.21 Osteomyelitis of vertebra (Occipito-atlanto-axial region)
0.235 0.765 0.000
M46.20 Osteomyelitis of vertebra (Multiple sites in spine)
0.235 0.765 0.000
M46.26 Osteomyelitis of vertebra (Lumbar region)
0.234 0.766 0.000
E14.9 Without complications
0.000 0.767 0.233
M46.39 Infection of intervertebral disc (pyogenic) (Site unspecified)
0.229 0.771 0.000
M46.38 Infection of intervertebral disc (pyogenic) (Sacral and sacrococcygeal region)
0.229 0.771 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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