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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523891
log Bayes Factor = 73.6043
Chromosome 6   position 31,038,976  (GRCh37) Explore rs2523891 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E10.9 Without complications
0.000 0.002 0.998
E10.3 With ophthalmic complications
0.000 0.005 0.995
L40 Psoriasis
0.000 0.006 0.994
D86.9 Sarcoidosis, unspecified
0.000 0.012 0.988
D86 Sarcoidosis
0.000 0.012 0.988
L40.5 Arthropathic psoriasis
0.000 0.015 0.985
D80-D89 Certain disorders involving the immune mechanism
0.000 0.023 0.977
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.030 0.970
E00-E07 Disorders of thyroid gland
0.069 0.035 0.896
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.038 0.962
D70 Agranulocytosis
0.000 0.043 0.957
L40.0 Psoriasis vulgaris
0.000 0.052 0.948
D50-D53 Nutritional anaemias
0.000 0.053 0.947
D51 Vitamin B12 deficiency anaemia
0.000 0.066 0.934
E10.2 With renal complications
0.000 0.085 0.915
E11 Non-insulin-dependent diabetes mellitus
0.000 0.088 0.912
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.094 0.906
D86.1 Sarcoidosis of lymph nodes
0.000 0.094 0.906
E05 Thyrotoxicosis [hyperthyroidism]
0.012 0.095 0.893
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.102 0.898
E10.8 With unspecified complications
0.000 0.112 0.888
D86.0 Sarcoidosis of lung
0.000 0.137 0.863
E10.4 With neurological complications
0.000 0.144 0.856
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.151 0.849
E11.5 With peripheral circulatory complications
0.000 0.152 0.848
E10.5 With peripheral circulatory complications
0.000 0.153 0.847
D72 Other disorders of white blood cells
0.000 0.159 0.841
E10.6 With other specified complications
0.000 0.161 0.838
D80 Immunodeficiency with predominantly antibody defects
0.000 0.183 0.817
E11.3 With ophthalmic complications
0.000 0.187 0.813
D53 Other nutritional anaemias
0.000 0.196 0.804
E11.4 With neurological complications
0.000 0.202 0.798
E10.0 With coma
0.000 0.209 0.791
E50-E64 Other nutritional deficiencies
0.000 0.212 0.788
D86.8 Sarcoidosis of other and combined sites
0.000 0.224 0.776
D55-D59 Haemolytic anaemias
0.000 0.231 0.769
E03 Other hypothyroidism
0.463 0.232 0.305
D83 Common variable immunodeficiency
0.000 0.232 0.768
L40.4 Guttate psoriasis
0.000 0.235 0.765
D75 Other diseases of blood and blood-forming organs
0.000 0.235 0.765
L40.1 Generalised pustular psoriasis
0.000 0.236 0.764
D86.3 Sarcoidosis of skin
0.000 0.240 0.760
D72.8 Other specified disorders of white blood cells
0.000 0.241 0.759
E83.1 Disorders of iron metabolism
0.000 0.246 0.754
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.247 0.753
E11.8 With unspecified complications
0.000 0.249 0.751
E70-E90 Metabolic disorders
0.000 0.257 0.743
E55 Vitamin D deficiency
0.000 0.268 0.732
E83 Disorders of mineral metabolism
0.000 0.270 0.730
E13 Other specified diabetes mellitus
0.000 0.273 0.727
E14 Unspecified diabetes mellitus
0.000 0.277 0.723
D59 Acquired haemolytic anaemia
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.286 0.714
L40.3 Pustulosis palmaris et plantaris
0.000 0.287 0.713
L40.2 Acrodermatitis continua
0.000 0.287 0.713
E20-E35 Disorders of other endocrine glands
0.000 0.289 0.711
E40-E46 Malnutrition
0.000 0.289 0.711
E11.1 With ketoacidosis
0.000 0.296 0.704
E27.1 Primary adrenocortical insufficiency
0.000 0.297 0.703
D53.9 Nutritional anaemia, unspecified
0.000 0.298 0.702
E27 Other disorders of adrenal gland
0.000 0.298 0.702
D81 Combined immunodeficiencies
0.000 0.300 0.700
E55.9 Vitamin D deficiency, unspecified
0.000 0.307 0.693
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.050 0.308 0.642
E00 Congenital iodine-deficiency syndrome
0.050 0.308 0.642
E88 Other metabolic disorders
0.000 0.309 0.691
D74 Methaemoglobinaemia
0.000 0.310 0.690
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.310 0.690
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.310 0.690
E16.1 Other hypoglycaemia
0.000 0.325 0.675
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.328 0.672
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.330 0.670
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.330 0.670
D51.2 Transcobalamin II deficiency
0.000 0.330 0.670
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.330 0.670
D82 Immunodeficiency associated with other major defects
0.000 0.332 0.668
E02 Subclinical iodine-deficiency hypothyroidism
0.049 0.336 0.616
E85 Amyloidosis
0.000 0.339 0.661
E11.6 With other specified complications
0.000 0.342 0.658
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.343 0.657
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.343 0.657
E11.7 With multiple complications
0.000 0.346 0.654
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.346 0.654
E05.5 Thyroid crisis or storm
0.009 0.351 0.640
E05.4 Thyrotoxicosis factitia
0.009 0.351 0.640
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.009 0.351 0.640
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.009 0.351 0.640
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.355 0.645
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.356 0.644
E06 Thyroiditis
0.037 0.363 0.600
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.364 0.636
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.365 0.635
D83.9 Common variable immunodeficiency, unspecified
0.000 0.382 0.618
D59.1 Other autoimmune haemolytic anaemias
0.000 0.388 0.612
E34 Other endocrine disorders
0.000 0.392 0.608
E05.8 Other thyrotoxicosis
0.009 0.395 0.597
D72.9 Disorder of white blood cells, unspecified
0.000 0.397 0.603
D72.0 Genetic anomalies of leukocytes
0.000 0.397 0.603
E85.4 Organ-limited amyloidosis
0.000 0.399 0.601
E14.3 With ophthalmic complications
0.000 0.403 0.597
D75.0 Familial erythrocytosis
0.000 0.403 0.596
D72.1 Eosinophilia
0.000 0.408 0.592
E51 Thiamine deficiency
0.000 0.409 0.591
E14.8 With unspecified complications
0.000 0.412 0.588
D84 Other immunodeficiencies
0.000 0.413 0.586
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.414 0.586
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.414 0.586
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.414 0.586
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.414 0.586
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.414 0.586
E20 Hypoparathyroidism
0.000 0.415 0.585
D53.8 Other specified nutritional anaemias
0.000 0.423 0.577
D53.2 Scorbutic anaemia
0.000 0.423 0.577
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.423 0.577
D53.0 Protein deficiency anaemia
0.000 0.423 0.577
D50 Iron deficiency anaemia
0.000 0.423 0.577
E13.9 Without complications
0.000 0.434 0.566
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.435 0.565
E63 Other nutritional deficiencies
0.000 0.435 0.565
E50 Vitamin A deficiency
0.000 0.435 0.565
E60 Dietary zinc deficiency
0.000 0.435 0.565
E59 Dietary selenium deficiency
0.000 0.435 0.565
E52 Niacin deficiency [pellagra]
0.000 0.435 0.565
L40.8 Other psoriasis
0.000 0.441 0.559
E79 Disorders of purine and pyrimidine metabolism
0.000 0.442 0.558
E14.1 With ketoacidosis
0.000 0.444 0.556
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.447 0.553
E70 Disorders of aromatic amino-acid metabolism
0.000 0.448 0.552
D55 Anaemia due to enzyme disorders
0.000 0.448 0.552
E03.5 Myxoedema coma
0.332 0.449 0.218
E03.4 Atrophy of thyroid (acquired)
0.332 0.449 0.218
E03.3 Postinfectious hypothyroidism
0.332 0.449 0.218
D83.8 Other common variable immunodeficiencies
0.000 0.449 0.550
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.449 0.550
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.449 0.550
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.449 0.550
E14.6 With other specified complications
0.000 0.451 0.549
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.456 0.544
E34.9 Endocrine disorder, unspecified
0.000 0.457 0.543
E03.0 Congenital hypothyroidism with diffuse goitre
0.331 0.457 0.212
E54 Ascorbic acid deficiency
0.000 0.459 0.541
E53 Deficiency of other B group vitamins
0.000 0.460 0.540
E07 Other disorders of thyroid
0.080 0.461 0.459
E88.9 Metabolic disorder, unspecified
0.000 0.461 0.539
D75.2 Essential thrombocytosis
0.000 0.461 0.539
E65-E68 Obesity and other hyperalimentation
0.000 0.464 0.536
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.464 0.536
E77 Disorders of glycoprotein metabolism
0.000 0.467 0.533
E76 Disorders of glycosaminoglycan metabolism
0.000 0.467 0.533
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.467 0.533
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.467 0.533
E06.9 Thyroiditis, unspecified
0.016 0.471 0.513
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.348 0.471 0.180
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.472 0.528
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.472 0.528
E03.1 Congenital hypothyroidism without goitre
0.295 0.472 0.233
E25 Adrenogenital disorders
0.000 0.475 0.525
E55.0 Rickets, active
0.000 0.475 0.525
D57 Sickle-cell disorders
0.000 0.475 0.524
D66 Hereditary factor VIII deficiency
0.000 0.475 0.525
E83.8 Other disorders of mineral metabolism
0.000 0.476 0.524
E83.2 Disorders of zinc metabolism
0.000 0.476 0.524
E83.0 Disorders of copper metabolism
0.000 0.476 0.524
E13.8 With unspecified complications
0.000 0.478 0.522
E13.7 With multiple complications
0.000 0.478 0.522
E13.6 With other specified complications
0.000 0.478 0.522
E13.5 With peripheral circulatory complications
0.000 0.478 0.522
E13.4 With neurological complications
0.000 0.478 0.522
E13.2 With renal complications
0.000 0.478 0.522
E13.1 With ketoacidosis
0.000 0.478 0.522
E13.0 With coma
0.000 0.478 0.522
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.481 0.519
E14.7 With multiple complications
0.000 0.482 0.518
E14.2 Withrenal complications
0.000 0.482 0.518
E14.0 With coma
0.000 0.482 0.518
E27.2 Addisonian crisis
0.000 0.483 0.517
E58 Dietary calcium deficiency
0.000 0.483 0.517
D59.8 Other acquired haemolytic anaemias
0.000 0.486 0.514
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.486 0.514
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.486 0.514
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.486 0.514
D59.3 Haemolytic-uraemic syndrome
0.000 0.486 0.514
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.486 0.514
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E56 Other vitamin deficiencies
0.000 0.487 0.513
E88.3 Tumour lysis syndrome
0.000 0.490 0.510
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.490 0.510
E32 Diseases of thymus
0.000 0.490 0.510
E31 Polyglandular dysfunction
0.000 0.490 0.510
E30 Disorders of puberty, not elsewhere classified
0.000 0.490 0.510
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.490 0.510
E45 Retarded development following protein-energy malnutrition
0.000 0.490 0.510
E43 Unspecified severe protein-energy malnutrition
0.000 0.490 0.510
E42 Marasmic kwashiorkor
0.000 0.490 0.510
E41 Nutritional marasmus
0.000 0.490 0.510
E40 Kwashiorkor
0.000 0.490 0.510
E46 Unspecified protein-energy malnutrition
0.000 0.495 0.505
E27.5 Adrenomedullary hyperfunction
0.000 0.497 0.503
E27.0 Other adrenocortical overactivity
0.000 0.497 0.503
D81.9 Combined immunodeficiency, unspecified
0.000 0.498 0.502
D81.8 Other combined immunodeficiencies
0.000 0.498 0.502
D81.7 Major histocompatibility complex class II deficiency
0.000 0.498 0.502
D81.6 Major histocompatibility complex class I deficiency
0.000 0.498 0.502
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.498 0.502
D81.4 Nezelof's syndrome
0.000 0.498 0.502
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.498 0.502
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.498 0.502
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.498 0.502
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.498 0.502
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.499 0.501
E05.9 Thyrotoxicosis, unspecified
0.000 0.501 0.498
E85.3 Secondary systemic amyloidosis
0.000 0.502 0.498
E14.5 With peripheral circulatory complications
0.000 0.502 0.498
E84 Cystic fibrosis
0.000 0.503 0.497
E34.0 Carcinoid syndrome
0.000 0.503 0.497
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.036 0.504 0.460
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.036 0.504 0.460
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.036 0.504 0.460
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.036 0.504 0.460
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.036 0.504 0.460
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.036 0.504 0.460
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.036 0.504 0.460
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.036 0.504 0.460
D74.9 Methaemoglobinaemia, unspecified
0.000 0.505 0.495
D74.8 Other methaemoglobinaemias
0.000 0.505 0.495
D74.0 Congenital methaemoglobinaemia
0.000 0.505 0.495
E20.9 Hypoparathyroidism, unspecified
0.000 0.505 0.495
E03.8 Other specified hypothyroidism
0.305 0.507 0.188
D75.1 Secondary polycythaemia
0.000 0.508 0.492
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.009 0.511 0.480
E72 Other disorders of amino-acid metabolism
0.000 0.512 0.488
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.513 0.487
D58 Other hereditary haemolytic anaemias
0.000 0.520 0.480
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.521 0.479
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.521 0.479
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.521 0.479
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.521 0.479
D82.2 Immunodeficiency with short-limbed stature
0.000 0.521 0.479
D82.0 Wiskott-Aldrich syndrome
0.000 0.521 0.479
E13.3 With ophthalmic complications
0.000 0.521 0.478
D52 Folate deficiency anaemia
0.000 0.524 0.476
E22 Hyperfunction of pituitary gland
0.000 0.524 0.476
D67 Hereditary factor IX deficiency
0.000 0.524 0.476
E85.8 Other amyloidosis
0.000 0.526 0.474
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.526 0.474
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.526 0.474
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.526 0.474
E14.4 With neurological complications
0.000 0.527 0.473
D50.9 Iron deficiency anaemia, unspecified
0.000 0.528 0.472
E11.2 With renal complications
0.000 0.529 0.471
E27.8 Other specified disorders of adrenal gland
0.000 0.530 0.470
D69 Purpura and other haemorrhagic conditions
0.000 0.531 0.469
E88.8 Other specified metabolic disorders
0.000 0.534 0.466
D84.1 Defects in the complement system
0.000 0.543 0.457
E06.4 Drug-induced thyroiditis
0.027 0.543 0.430
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.027 0.543 0.430
E06.0 Acute thyroiditis
0.027 0.543 0.430
E24 Cushing's syndrome
0.000 0.543 0.456
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.544 0.456
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.544 0.456
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.544 0.456
E74 Other disorders of carbohydrate metabolism
0.000 0.550 0.450
E51.2 Wernicke's encephalopathy
0.000 0.550 0.449
E85.9 Amyloidosis, unspecified
0.000 0.551 0.449
D82.1 Di George's syndrome
0.000 0.553 0.447
E86 Volume depletion
0.000 0.561 0.439
E04 Other non-toxic goitre
0.005 0.563 0.433
E34.5 Androgen resistance syndrome
0.000 0.564 0.436
E34.4 Constitutional tall stature
0.000 0.564 0.436
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.564 0.436
E34.1 Other hypersecretion of intestinal hormones
0.000 0.564 0.436
K90 Intestinal malabsorption
0.000 0.566 0.434
E73 Lactose intolerance
0.000 0.571 0.429
D50.8 Other iron deficiency anaemias
0.000 0.574 0.426
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.574 0.426
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.575 0.425
E51.9 Thiamine deficiency, unspecified
0.000 0.576 0.423
E51.8 Other manifestations of thiamine deficiency
0.000 0.576 0.423
E51.1 Beriberi
0.000 0.576 0.423
D84.8 Other specified immunodeficiencies
0.000 0.579 0.420
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.579 0.420
E29 Testicular dysfunction
0.000 0.580 0.420
E20.8 Other hypoparathyroidism
0.000 0.580 0.419
E20.1 Pseudohypoparathyroidism
0.000 0.580 0.419
E20.0 Idiopathic hypoparathyroidism
0.000 0.580 0.419
E34.3 Short stature, not elsewhere classified
0.000 0.582 0.418
E88.2 Lipomatosis, not elsewhere classified
0.000 0.583 0.417
E61 Deficiency of other nutrient elements
0.000 0.585 0.415
E70.3 Albinism
0.000 0.585 0.415
D50.1 Sideropenic dysphagia
0.000 0.586 0.413
E53.9 Vitamin B deficiency, unspecified
0.000 0.588 0.412
E06.3 Autoimmune thyroiditis
0.015 0.592 0.393
E07.8 Other specified disorders of thyroid
0.041 0.594 0.366
E50.9 Vitamin A deficiency, unspecified
0.000 0.595 0.405
E50.8 Other manifestations of vitamin A deficiency
0.000 0.595 0.405
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.595 0.405
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.595 0.405
E50.5 Vitamin A deficiency with night blindness
0.000 0.595 0.405
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.595 0.405
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.595 0.405
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.595 0.405
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.595 0.405
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.595 0.405
E63.9 Nutritional deficiency, unspecified
0.000 0.595 0.405
E63.8 Other specified nutritional deficiencies
0.000 0.595 0.405
E63.1 Imbalance of constituents of food intake
0.000 0.595 0.405
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.595 0.405
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.595 0.405
E64.8 Sequelae of other nutritional deficiencies
0.000 0.595 0.405
E64.3 Sequelae of rickets
0.000 0.595 0.405
E64.2 Sequelae of vitamin C deficiency
0.000 0.595 0.405
E64.1 Sequelae of vitamin A deficiency
0.000 0.595 0.405
E64.0 Sequelae of protein-energy malnutrition
0.000 0.595 0.405
D76.3 Other histiocytosis syndromes
0.000 0.599 0.401
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.600 0.400
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.600 0.400
E79.1 Lesch-Nyhan syndrome
0.000 0.600 0.400
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.600 0.400
E06.1 Subacute thyroiditis
0.030 0.602 0.369
E11.0 With coma
0.001 0.603 0.397
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.604 0.396
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.604 0.396
E70.2 Disorders of tyrosine metabolism
0.000 0.604 0.396
E70.1 Other hyperphenylalaninaemias
0.000 0.604 0.396
E70.0 Classical phenylketonuria
0.000 0.604 0.396
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.604 0.395
D55.8 Other anaemias due to enzyme disorders
0.000 0.604 0.395
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.604 0.395
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.604 0.395
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.604 0.395
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.604 0.395
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.608 0.392
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.609 0.391
D69.2 Other nonthrombocytopenic purpura
0.000 0.610 0.390
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.610 0.389
E53.1 Pyridoxine deficiency
0.000 0.613 0.387
E53.0 Riboflavin deficiency
0.000 0.613 0.387
D69.6 Thrombocytopenia, unspecified
0.000 0.613 0.387
E07.1 Dyshormogenetic goitre
0.057 0.613 0.329
E07.0 Hypersecretion of calcitonin
0.057 0.613 0.329
E67 Other hyperalimentation
0.000 0.616 0.384
E68 Sequelae of hyperalimentation
0.000 0.616 0.384
E71.3 Disorders of fatty-acid metabolism
0.000 0.618 0.382
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.618 0.382
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.618 0.382
E71.0 Maple-syrup-urine disease
0.000 0.618 0.382
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.618 0.382
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.618 0.382
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.618 0.382
E76.2 Other mucopolysaccharidoses
0.000 0.618 0.382
E76.1 Mucopolysaccharidosis, type II
0.000 0.618 0.382
E76.0 Mucopolysaccharidosis, type I
0.000 0.618 0.382
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.618 0.382
E77.8 Other disorders of glycoprotein metabolism
0.000 0.618 0.382
E77.1 Defects in glycoprotein degradation
0.000 0.618 0.382
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.618 0.382
D69.5 Secondary thrombocytopenia
0.000 0.619 0.380
E06.5 Other chronic thyroiditis
0.030 0.621 0.349
D89.3 Immune reconstitution syndrome
0.000 0.621 0.379
E22.1 Hyperprolactinaemia
0.000 0.623 0.377
E25.9 Adrenogenital disorder, unspecified
0.000 0.623 0.377
E25.8 Other adrenogenital disorders
0.000 0.623 0.377
D57.8 Other sickle-cell disorders
0.000 0.624 0.376
D57.3 Sickle-cell trait
0.000 0.624 0.376
D57.2 Double heterozygous sickling disorders
0.000 0.624 0.376
D57.0 Sickle-cell anaemia with crisis
0.000 0.624 0.376
D56 Thalassaemia
0.001 0.631 0.368
E24.0 Pituitary-dependent Cushing's disease
0.000 0.632 0.368
E56.9 Vitamin deficiency, unspecified
0.000 0.632 0.368
E56.8 Deficiency of other vitamins
0.000 0.632 0.368
E56.0 Deficiency of vitamin E
0.000 0.632 0.368
E30.9 Disorder of puberty, unspecified
0.000 0.634 0.366
E30.8 Other disorders of puberty
0.000 0.634 0.366
E30.1 Precocious puberty
0.000 0.634 0.366
E30.0 Delayed puberty
0.000 0.634 0.366
E31.9 Polyglandular dysfunction, unspecified
0.000 0.634 0.366
E31.8 Other polyglandular dysfunction
0.000 0.634 0.366
E31.1 Polyglandular hyperfunction
0.000 0.634 0.366
E31.0 Autoimmune polyglandular failure
0.000 0.634 0.366
E32.9 Disease of thymus, unspecified
0.000 0.634 0.366
E32.8 Other diseases of thymus
0.000 0.634 0.366
E32.1 Abscess of thymus
0.000 0.634 0.366
E32.0 Persistent hyperplasia of thymus
0.000 0.634 0.366
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.634 0.366
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.634 0.366
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.634 0.366
E44.1 Mild protein-energy malnutrition
0.000 0.634 0.366
E44.0 Moderate protein-energy malnutrition
0.000 0.634 0.366
D89.1 Cryoglobulinaemia
0.000 0.637 0.362
E26 Hyperaldosteronism
0.000 0.640 0.360
E04.0 Non-toxic diffuse goitre
0.002 0.641 0.356
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.642 0.358
E84.8 Cystic fibrosis with other manifestations
0.000 0.643 0.356
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.643 0.356
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.643 0.356
D58.2 Other haemoglobinopathies
0.000 0.646 0.354
E22.0 Acromegaly and pituitary gigantism
0.000 0.646 0.353
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.650 0.350
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.650 0.350
E72.5 Disorders of glycine metabolism
0.000 0.650 0.350
E72.4 Disorders of ornithine metabolism
0.000 0.650 0.350
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.650 0.350
E72.2 Disorders of urea cycle metabolism
0.000 0.650 0.350
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.650 0.350
D57.1 Sickle-cell anaemia without crisis
0.000 0.651 0.349
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.656 0.344
D58.1 Hereditary elliptocytosis
0.000 0.656 0.344
D52.8 Other folate deficiency anaemias
0.000 0.658 0.341
D52.1 Drug-induced folate deficiency anaemia
0.000 0.658 0.341
D52.0 Dietary folate deficiency anaemia
0.000 0.658 0.341
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.658 0.341
E22.8 Other hyperfunction of pituitary gland
0.000 0.658 0.341
D69.9 Haemorrhagic condition, unspecified
0.000 0.659 0.341
E34.8 Other specified endocrine disorders
0.000 0.662 0.338
K90.9 Intestinal malabsorption, unspecified
0.000 0.663 0.337
D69.8 Other specified haemorrhagic conditions
0.000 0.664 0.336
E66 Obesity
0.000 0.664 0.336
E04.9 Non-toxic goitre, unspecified
0.001 0.665 0.334
E27.9 Disorder of adrenal gland, unspecified
0.000 0.667 0.333
E53.8 Deficiency of other specified B group vitamins
0.000 0.672 0.328
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.672 0.327
E24.3 Ectopic ACTH syndrome
0.000 0.672 0.327
E24.1 Nelson's syndrome
0.000 0.672 0.327
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.677 0.322
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.677 0.322
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.677 0.322
E74.2 Disorders of galactose metabolism
0.000 0.677 0.322
E74.1 Disorders of fructose metabolism
0.000 0.677 0.322
E74.0 Glycogen storage disease
0.000 0.677 0.322
E84.9 Cystic fibrosis, unspecified
0.000 0.679 0.321
D69.1 Qualitative platelet defects
0.000 0.683 0.317
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.683 0.317
E56.1 Deficiency of vitamin K
0.000 0.684 0.315
K90.8 Other intestinal malabsorption
0.000 0.685 0.315
E24.8 Other Cushing's syndrome
0.000 0.685 0.314
E04.8 Other specified non-toxic goitre
0.004 0.686 0.310
K90.3 Pancreatic steatorrhoea
0.000 0.688 0.311
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.688 0.311
K90.1 Tropical sprue
0.000 0.688 0.311
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.689 0.311
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.690 0.309
E73.8 Other lactose intolerance
0.000 0.692 0.308
E73.1 Secondary lactase deficiency
0.000 0.692 0.308
E73.0 Congenital lactase deficiency
0.000 0.692 0.308
E72.0 Disorders of amino-acid transport
0.000 0.694 0.306
E75.6 Lipid storage disorder, unspecified
0.000 0.694 0.305
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.694 0.305
E75.3 Sphingolipidosis, unspecified
0.000 0.694 0.305
E75.1 Other gangliosidosis
0.000 0.694 0.305
E75.0 GM2 gangliosidosis
0.000 0.694 0.305
E29.9 Testicular dysfunction, unspecified
0.000 0.699 0.301
E29.8 Other testicular dysfunction
0.000 0.699 0.301
E29.0 Testicular hyperfunction
0.000 0.699 0.301
D58.0 Hereditary spherocytosis
0.000 0.700 0.300
E61.9 Deficiency of nutrient element, unspecified
0.000 0.702 0.298
E61.8 Deficiency of other specified nutrient elements
0.000 0.702 0.298
E61.7 Deficiency of multiple nutrient elements
0.000 0.702 0.298
E61.6 Vanadium deficiency
0.000 0.702 0.298
E61.5 Molybdenum deficiency
0.000 0.702 0.298
E61.4 Chromium deficiency
0.000 0.702 0.298
E61.3 Manganese deficiency
0.000 0.702 0.298
E61.0 Copper deficiency
0.000 0.702 0.298
D69.4 Other primary thrombocytopenia
0.000 0.707 0.293
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.716 0.284
E65 Localised adiposity
0.000 0.716 0.284
E66.0 Obesity due to excess calories
0.000 0.716 0.284
E24.9 Cushing's syndrome, unspecified
0.000 0.717 0.283
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.720 0.280
E80.2 Other porphyria
0.000 0.721 0.278
E24.2 Drug-induced Cushing's syndrome
0.000 0.723 0.276
E67.8 Other specified hyperalimentation
0.000 0.724 0.276
E67.3 Hypervitaminosis D
0.000 0.724 0.276

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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