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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2596438
log Bayes Factor = 49.3999
Chromosome 6   position 31,339,871  (GRCh37) Explore rs2596438 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.001 0.999
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
E14 Unspecified diabetes mellitus
0.000 0.002 0.998
E70-E90 Metabolic disorders
0.000 0.004 0.995
E11 Non-insulin-dependent diabetes mellitus
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E14.9 Without complications
0.000 0.006 0.994
E10.1 With ketoacidosis
0.000 0.016 0.984
E11.9 Without complications
0.000 0.016 0.984
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.022 0.978
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.048 0.952
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.053 0.947
E10.4 With neurological complications
0.000 0.062 0.938
K51 Ulcerative colitis
0.932 0.068 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.068 0.932
E11.1 With ketoacidosis
0.000 0.070 0.930
K51.9 Ulcerative colitis, unspecified
0.929 0.071 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.076 0.924
E16 Other disorders of pancreatic internal secretion
0.000 0.082 0.918
K51.3 Ulcerative (chronic) rectosigmoiditis
0.910 0.090 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.100 0.900
E14.3 With ophthalmic complications
0.000 0.102 0.898
E11.0 With coma
0.000 0.103 0.897
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.105 0.895
K51.4 Pseudopolyposis of colon
0.882 0.118 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.119 0.881
G35-G37 Demyelinating diseases of the central nervous system
0.881 0.119 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.123 0.877
E07 Other disorders of thyroid
0.000 0.126 0.874
K51.8 Other ulcerative colitis
0.866 0.134 0.000
E10.8 With unspecified complications
0.000 0.139 0.861
E74 Other disorders of carbohydrate metabolism
0.000 0.152 0.847
E10.2 With renal complications
0.000 0.155 0.845
G37 Other demyelinating diseases of central nervous system
0.838 0.162 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.162 0.838
E85 Amyloidosis
0.000 0.164 0.836
E78.2 Mixed hyperlipidaemia
0.000 0.187 0.813
G37.9 Demyelinating disease of central nervous system, unspecified
0.807 0.193 0.000
K51.2 Ulcerative (chronic) proctitis
0.806 0.194 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.197 0.803
E78.1 Pure hyperglyceridaemia
0.000 0.208 0.792
K51.0 Ulcerative (chronic) enterocolitis
0.791 0.209 0.000
E78.5 Hyperlipidaemia, unspecified
0.000 0.221 0.779
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.225 0.775
E16.1 Other hypoglycaemia
0.000 0.232 0.768
E10.0 With coma
0.000 0.232 0.768
K51.5 Mucosal proctocolitis
0.764 0.236 0.000
E10.6 With other specified complications
0.000 0.236 0.764
E20-E35 Disorders of other endocrine glands
0.000 0.241 0.759
E10.5 With peripheral circulatory complications
0.000 0.244 0.756
E14.4 With neurological complications
0.000 0.244 0.756
E05.8 Other thyrotoxicosis
0.000 0.257 0.743
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.259 0.741
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.267 0.732
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.270 0.730
E14.5 With peripheral circulatory complications
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.3 With ophthalmic complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.284 0.716
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E14.8 With unspecified complications
0.000 0.284 0.716
E14.7 With multiple complications
0.000 0.284 0.716
E14.6 With other specified complications
0.000 0.284 0.716
E14.2 Withrenal complications
0.000 0.284 0.716
E14.1 With ketoacidosis
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
E11.7 With multiple complications
0.000 0.286 0.714
E13 Other specified diabetes mellitus
0.000 0.290 0.710
E78.4 Other hyperlipidaemia
0.000 0.293 0.707
E84 Cystic fibrosis
0.000 0.295 0.705
E79 Disorders of purine and pyrimidine metabolism
0.000 0.296 0.704
E85.9 Amyloidosis, unspecified
0.000 0.299 0.701
E11.5 With peripheral circulatory complications
0.000 0.305 0.695
E40-E46 Malnutrition
0.000 0.312 0.688
E15 Nondiabetic hypoglycaemic coma
0.000 0.317 0.683
E06 Thyroiditis
0.000 0.319 0.681
G37.8 Other specified demyelinating diseases of central nervous system
0.679 0.321 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.324 0.676
E11.2 With renal complications
0.000 0.324 0.676
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.329 0.671
E11.8 With unspecified complications
0.000 0.335 0.665
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.337 0.663
E03.8 Other specified hypothyroidism
0.000 0.340 0.660
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.342 0.658
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.342 0.658
E16.4 Abnormal secretion of gastrin
0.000 0.342 0.658
E16.3 Increased secretion of glucagon
0.000 0.342 0.658
E85.4 Organ-limited amyloidosis
0.000 0.344 0.656
E28 Ovarian dysfunction
0.000 0.345 0.655
E73 Lactose intolerance
0.000 0.347 0.653
J45.9 Asthma, unspecified
0.000 0.352 0.648
E11.6 With other specified complications
0.000 0.357 0.643
E23 Hypofunction and other disorders of pituitary gland
0.000 0.365 0.635
I10 Essential (primary) hypertension
0.000 0.367 0.633
G36 Other acute disseminated demyelination
0.631 0.369 0.000
E07.1 Dyshormogenetic goitre
0.000 0.373 0.627
E07.0 Hypersecretion of calcitonin
0.000 0.373 0.627
K51.1 Ulcerative (chronic) ileocolitis
0.625 0.375 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.375 0.625
E50-E64 Other nutritional deficiencies
0.000 0.388 0.612
E29 Testicular dysfunction
0.000 0.390 0.609
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.392 0.608
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.392 0.608
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.392 0.608
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.392 0.608
E74.2 Disorders of galactose metabolism
0.000 0.392 0.608
E74.1 Disorders of fructose metabolism
0.000 0.392 0.608
E74.0 Glycogen storage disease
0.000 0.392 0.608
G37.5 Concentric sclerosis [Balo]
0.601 0.399 0.000
G37.4 Subacute necrotising myelitis
0.601 0.399 0.000
G37.2 Central pontine myelinolysis
0.601 0.399 0.000
G37.1 Central demyelination of corpus callosum
0.601 0.399 0.000
G37.0 Diffuse sclerosis
0.601 0.399 0.000
E28.2 Polycystic ovarian syndrome
0.000 0.399 0.601
E85.8 Other amyloidosis
0.000 0.401 0.599
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.401 0.599
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.401 0.599
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.401 0.599
E24 Cushing's syndrome
0.000 0.401 0.598
E83 Disorders of mineral metabolism
0.355 0.406 0.239
M06 Other rheumatoid arthritis
0.000 0.410 0.590
E85.3 Secondary systemic amyloidosis
0.000 0.428 0.572
E07.8 Other specified disorders of thyroid
0.000 0.438 0.562
M06.3 Rheumatoid nodule
0.000 0.455 0.545
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.455 0.544
E32 Diseases of thymus
0.000 0.455 0.544
E31 Polyglandular dysfunction
0.000 0.455 0.544
E30 Disorders of puberty, not elsewhere classified
0.000 0.455 0.544
E25 Adrenogenital disorders
0.000 0.455 0.544
E23.7 Disorder of pituitary gland, unspecified
0.000 0.458 0.542
M45 Ankylosing spondylitis
0.000 0.460 0.540
E26 Hyperaldosteronism
0.000 0.461 0.539
E61 Deficiency of other nutrient elements
0.000 0.462 0.538
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.466 0.534
E22 Hyperfunction of pituitary gland
0.000 0.466 0.534
E89.3 Postprocedural hypopituitarism
0.000 0.469 0.531
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.512
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.512
E70.3 Albinism
0.000 0.488 0.512
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.512
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.512
E70.0 Classical phenylketonuria
0.000 0.488 0.512
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.512
E71.0 Maple-syrup-urine disease
0.000 0.488 0.512
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.512
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.512
E72.5 Disorders of glycine metabolism
0.000 0.488 0.512
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.512
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.512
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.512
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.512
E72.0 Disorders of amino-acid transport
0.000 0.488 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.512
E13.8 With unspecified complications
0.000 0.491 0.509
E13.7 With multiple complications
0.000 0.491 0.509
E13.6 With other specified complications
0.000 0.491 0.509
E13.5 With peripheral circulatory complications
0.000 0.491 0.509
E13.4 With neurological complications
0.000 0.491 0.509
E13.3 With ophthalmic complications
0.000 0.491 0.509
E13.2 With renal complications
0.000 0.491 0.509
E13.1 With ketoacidosis
0.000 0.491 0.509
E13.0 With coma
0.000 0.491 0.509
E84.8 Cystic fibrosis with other manifestations
0.000 0.495 0.505
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.495 0.505
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.495 0.505
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.495 0.505
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.495 0.505
E79.1 Lesch-Nyhan syndrome
0.000 0.495 0.505
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.496 0.503
E29.1 Testicular hypofunction
0.000 0.498 0.502
E13.9 Without complications
0.000 0.499 0.501
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.501 0.499 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.499 0.501
E84.9 Cystic fibrosis, unspecified
0.000 0.504 0.496
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.505 0.495
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.506 0.493
E45 Retarded development following protein-energy malnutrition
0.000 0.506 0.493
E43 Unspecified severe protein-energy malnutrition
0.000 0.506 0.493
E42 Marasmic kwashiorkor
0.000 0.506 0.493
E41 Nutritional marasmus
0.000 0.506 0.493
E40 Kwashiorkor
0.000 0.506 0.493
E61.1 Iron deficiency
0.000 0.508 0.492
M06.34 Rheumatoid nodule (Hand)
0.000 0.509 0.491
E06.5 Other chronic thyroiditis
0.000 0.512 0.488
E06.4 Drug-induced thyroiditis
0.000 0.512 0.488
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.512 0.488
E06.1 Subacute thyroiditis
0.000 0.512 0.488
E06.0 Acute thyroiditis
0.000 0.512 0.488
E23.6 Other disorders of pituitary gland
0.000 0.513 0.487
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.514 0.486
E23.2 Diabetes insipidus
0.000 0.515 0.485
E75.6 Lipid storage disorder, unspecified
0.000 0.515 0.485
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.515 0.485
E75.3 Sphingolipidosis, unspecified
0.000 0.515 0.485
E75.2 Other sphingolipidosis
0.000 0.515 0.485
E75.1 Other gangliosidosis
0.000 0.515 0.485
E75.0 GM2 gangliosidosis
0.000 0.515 0.485
E24.9 Cushing's syndrome, unspecified
0.000 0.517 0.483
E06.9 Thyroiditis, unspecified
0.000 0.526 0.474
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.529 0.471
E28.9 Ovarian dysfunction, unspecified
0.000 0.530 0.470
E28.8 Other ovarian dysfunction
0.000 0.530 0.470
E28.1 Androgen excess
0.000 0.530 0.470
E28.0 Oestrogen excess
0.000 0.530 0.470
E73.8 Other lactose intolerance
0.000 0.532 0.468
E73.1 Secondary lactase deficiency
0.000 0.532 0.468
E73.0 Congenital lactase deficiency
0.000 0.532 0.468
E06.3 Autoimmune thyroiditis
0.000 0.533 0.467
E46 Unspecified protein-energy malnutrition
0.000 0.535 0.464
E34 Other endocrine disorders
0.000 0.536 0.464
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.540 0.459
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.541 0.459
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.544 0.455
E23.1 Drug-induced hypopituitarism
0.000 0.544 0.455
E21.3 Hyperparathyroidism, unspecified
0.000 0.545 0.455
G36.9 Acute disseminated demyelination, unspecified
0.453 0.547 0.000
G36.8 Other specified acute disseminated demyelination
0.453 0.547 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.453 0.547 0.000
G36.0 Neuromyelitis optica [Devic]
0.453 0.547 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.549 0.451
E75.5 Other lipid storage disorders
0.000 0.553 0.447
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.561 0.439
E63 Other nutritional deficiencies
0.000 0.561 0.439
E56 Other vitamin deficiencies
0.000 0.561 0.439
E51 Thiamine deficiency
0.000 0.561 0.439
E50 Vitamin A deficiency
0.000 0.561 0.439
E60 Dietary zinc deficiency
0.000 0.561 0.439
E59 Dietary selenium deficiency
0.000 0.561 0.439
E58 Dietary calcium deficiency
0.000 0.561 0.439
E54 Ascorbic acid deficiency
0.000 0.561 0.439
E52 Niacin deficiency [pellagra]
0.000 0.561 0.439
E11.4 With neurological complications
0.000 0.563 0.437
E89.4 Postprocedural ovarian failure
0.000 0.563 0.437
E29.9 Testicular dysfunction, unspecified
0.000 0.563 0.437
E29.8 Other testicular dysfunction
0.000 0.563 0.437
E29.0 Testicular hyperfunction
0.000 0.563 0.437
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.564 0.436
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.564 0.436
E89.5 Postprocedural testicular hypofunction
0.000 0.564 0.436
E89.1 Postprocedural hypoinsulinaemia
0.000 0.564 0.436
E24.8 Other Cushing's syndrome
0.000 0.571 0.429
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.571 0.429
E24.3 Ectopic ACTH syndrome
0.000 0.571 0.429
E24.2 Drug-induced Cushing's syndrome
0.000 0.571 0.429
E24.1 Nelson's syndrome
0.000 0.571 0.429
E24.0 Pituitary-dependent Cushing's disease
0.000 0.571 0.429
E83.9 Disorder of mineral metabolism, unspecified
0.254 0.574 0.172
E83.8 Other disorders of mineral metabolism
0.254 0.574 0.172
E83.2 Disorders of zinc metabolism
0.254 0.574 0.172
E83.0 Disorders of copper metabolism
0.254 0.574 0.172
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.574 0.426
I10-I15 Hypertensive diseases
0.000 0.575 0.425
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.575 0.425
M06.8 Other specified rheumatoid arthritis
0.000 0.577 0.423
M06.2 Rheumatoid bursitis
0.000 0.577 0.423
M06.1 Adult-onset Still's disease
0.000 0.577 0.423
E20 Hypoparathyroidism
0.001 0.581 0.419
E73.9 Lactose intolerance, unspecified
0.000 0.593 0.407
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.593 0.407
E28.3 Primary ovarian failure
0.000 0.595 0.405
E88 Other metabolic disorders
0.000 0.603 0.397
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.609 0.391
M06.38 Rheumatoid nodule (Other)
0.000 0.609 0.391
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.609 0.391
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.609 0.391
M06.33 Rheumatoid nodule (Forearm)
0.000 0.609 0.391
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.609 0.391
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.609 0.391
E25.9 Adrenogenital disorder, unspecified
0.000 0.609 0.390
E25.8 Other adrenogenital disorders
0.000 0.609 0.390
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.609 0.390
E30.9 Disorder of puberty, unspecified
0.000 0.609 0.390
E30.8 Other disorders of puberty
0.000 0.609 0.390
E30.1 Precocious puberty
0.000 0.609 0.390
E30.0 Delayed puberty
0.000 0.609 0.390
E31.9 Polyglandular dysfunction, unspecified
0.000 0.609 0.390
E31.8 Other polyglandular dysfunction
0.000 0.609 0.390
E31.1 Polyglandular hyperfunction
0.000 0.609 0.390
E31.0 Autoimmune polyglandular failure
0.000 0.609 0.390
E32.9 Disease of thymus, unspecified
0.000 0.609 0.390
E32.8 Other diseases of thymus
0.000 0.609 0.390
E32.1 Abscess of thymus
0.000 0.609 0.390
E32.0 Persistent hyperplasia of thymus
0.000 0.609 0.390
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.609 0.390
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.609 0.390
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.609 0.390
M06.4 Inflammatory polyarthropathy
0.000 0.612 0.387
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.613 0.387
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.613 0.387
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.613 0.387
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.613 0.387
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.613 0.387
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.613 0.387
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.613 0.387
E26.9 Hyperaldosteronism, unspecified
0.000 0.614 0.386
E26.8 Other hyperaldosteronism
0.000 0.614 0.386
E26.1 Secondary hyperaldosteronism
0.000 0.614 0.386
E23.0 Hypopituitarism
0.000 0.614 0.386
E61.9 Deficiency of nutrient element, unspecified
0.000 0.614 0.385
E61.8 Deficiency of other specified nutrient elements
0.000 0.614 0.385
E61.7 Deficiency of multiple nutrient elements
0.000 0.614 0.385
E61.6 Vanadium deficiency
0.000 0.614 0.385
E61.5 Molybdenum deficiency
0.000 0.614 0.385
E61.4 Chromium deficiency
0.000 0.614 0.385
E61.3 Manganese deficiency
0.000 0.614 0.385
E61.0 Copper deficiency
0.000 0.614 0.385
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.617 0.383
E21.4 Other specified disorders of parathyroid gland
0.000 0.617 0.383
E21.2 Other hyperparathyroidism
0.000 0.617 0.383
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.617 0.383
E22.8 Other hyperfunction of pituitary gland
0.000 0.617 0.383
E26.0 Primary hyperaldosteronism
0.000 0.619 0.380
E22.0 Acromegaly and pituitary gigantism
0.000 0.620 0.380
I12 Hypertensive renal disease
0.000 0.621 0.379
Chapter VI Diseases of the nervous system
0.378 0.622 0.000
E83.3 Disorders of phosphorus metabolism
0.258 0.631 0.111
G30-G32 Other degenerative diseases of the nervous system
0.369 0.631 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.362 0.638 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.361 0.638 0.000
E61.2 Magnesium deficiency
0.000 0.640 0.359
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.641 0.359
E80.5 Crigler-Najjar syndrome
0.000 0.641 0.359
E80.3 Defects of catalase and peroxydase
0.000 0.641 0.359
E80.2 Other porphyria
0.000 0.641 0.359
E80.0 Hereditary erythropoietic porphyria
0.000 0.641 0.359
E44.1 Mild protein-energy malnutrition
0.000 0.646 0.354
E44.0 Moderate protein-energy malnutrition
0.000 0.646 0.354
E80.6 Other disorders of bilirubin metabolism
0.000 0.646 0.354
I12.9 Hypertensive renal disease without renal failure
0.000 0.653 0.347
E22.1 Hyperprolactinaemia
0.000 0.654 0.345
E80.1 Porphyria cutanea tarda
0.000 0.656 0.344
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.659 0.341
G20-G26 Extrapyramidal and movement disorders
0.341 0.659 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.335 0.665 0.000
G20 Parkinson's disease
0.334 0.666 0.000
E34.5 Androgen resistance syndrome
0.000 0.667 0.332
E34.4 Constitutional tall stature
0.000 0.667 0.332
E34.3 Short stature, not elsewhere classified
0.000 0.667 0.332
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.667 0.332
E34.1 Other hypersecretion of intestinal hormones
0.000 0.667 0.332
E67 Other hyperalimentation
0.000 0.676 0.323
E68 Sequelae of hyperalimentation
0.000 0.676 0.323
E55 Vitamin D deficiency
0.000 0.677 0.323
E34.8 Other specified endocrine disorders
0.000 0.685 0.315
I15 Secondary hypertension
0.000 0.685 0.315
E50.9 Vitamin A deficiency, unspecified
0.000 0.685 0.315
E50.8 Other manifestations of vitamin A deficiency
0.000 0.685 0.315
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.685 0.315
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.685 0.315
E50.5 Vitamin A deficiency with night blindness
0.000 0.685 0.315
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.685 0.315
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.685 0.315
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.685 0.315
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.685 0.315
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.685 0.315
E51.9 Thiamine deficiency, unspecified
0.000 0.685 0.315
E51.8 Other manifestations of thiamine deficiency
0.000 0.685 0.315
E51.2 Wernicke's encephalopathy
0.000 0.685 0.315
E51.1 Beriberi
0.000 0.685 0.315
E56.9 Vitamin deficiency, unspecified
0.000 0.685 0.315
E56.8 Deficiency of other vitamins
0.000 0.685 0.315
E56.1 Deficiency of vitamin K
0.000 0.685 0.315
E56.0 Deficiency of vitamin E
0.000 0.685 0.315
E63.9 Nutritional deficiency, unspecified
0.000 0.685 0.315
E63.8 Other specified nutritional deficiencies
0.000 0.685 0.315
E63.1 Imbalance of constituents of food intake
0.000 0.685 0.315
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.685 0.315
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.685 0.315
E64.8 Sequelae of other nutritional deficiencies
0.000 0.685 0.315
E64.3 Sequelae of rickets
0.000 0.685 0.315
E64.2 Sequelae of vitamin C deficiency
0.000 0.685 0.315
E64.1 Sequelae of vitamin A deficiency
0.000 0.685 0.315
E64.0 Sequelae of protein-energy malnutrition
0.000 0.685 0.315
E65 Localised adiposity
0.000 0.686 0.314
E34.0 Carcinoid syndrome
0.000 0.687 0.313
G80-G83 Cerebral palsy and other paralytic syndromes
0.310 0.690 0.000
E89.2 Postprocedural hypoparathyroidism
0.000 0.694 0.305
I13 Hypertensive heart and renal disease
0.000 0.695 0.305
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.696 0.304
M06.18 Adult-onset Still's disease (Other)
0.000 0.696 0.304
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.696 0.304
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.696 0.304
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.696 0.304
M06.14 Adult-onset Still's disease (Hand)
0.000 0.696 0.304
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.696 0.304
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.696 0.304
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.696 0.304
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.696 0.304
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.696 0.304
M06.28 Rheumatoid bursitis (Other)
0.000 0.696 0.304
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.696 0.304
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.696 0.304
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.696 0.304
M06.24 Rheumatoid bursitis (Hand)
0.000 0.696 0.304
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.696 0.304
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.696 0.304
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.696 0.304
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.696 0.304
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.696 0.304
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.696 0.304
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.696 0.304
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.696 0.304
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.696 0.304
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.696 0.304
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.696 0.304
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.696 0.304
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.696 0.304
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.696 0.304
E20.8 Other hypoparathyroidism
0.001 0.699 0.300
E20.1 Pseudohypoparathyroidism
0.001 0.699 0.300
E20.0 Idiopathic hypoparathyroidism
0.001 0.699 0.300
E34.9 Endocrine disorder, unspecified
0.000 0.699 0.301
I11 Hypertensive heart disease
0.000 0.700 0.300
E21.0 Primary hyperparathyroidism
0.000 0.708 0.292
M06.0 Seronegative rheumatoid arthritis
0.000 0.708 0.291
G31.2 Degeneration of nervous system due to alcohol
0.291 0.709 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.286 0.714 0.000
E88.9 Metabolic disorder, unspecified
0.000 0.715 0.285
E27 Other disorders of adrenal gland
0.000 0.720 0.280
G30 Alzheimer's disease
0.279 0.721 0.000
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.722 0.278
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.722 0.278
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.722 0.278
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.722 0.278
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.722 0.278
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.722 0.278
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.722 0.278
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.722 0.278
E88.2 Lipomatosis, not elsewhere classified
0.000 0.725 0.274
E83.4 Disorders of magnesium metabolism
0.081 0.727 0.192
G09 Sequelae of inflammatory diseases of central nervous system
0.273 0.727 0.000
G82 Paraplegia and tetraplegia
0.273 0.727 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.271 0.728 0.000
E88.8 Other specified metabolic disorders
0.000 0.731 0.268
K90 Intestinal malabsorption
0.000 0.731 0.269
I12.0 Hypertensive renal disease with renal failure
0.000 0.732 0.268
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.732 0.267
E83.5 Disorders of calcium metabolism
0.245 0.735 0.021

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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