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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2596454
log Bayes Factor = 77.3073
Chromosome 6   position 31,436,312  (GRCh37) Explore rs2596454 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E11 Non-insulin-dependent diabetes mellitus
0.000 0.002 0.998
E11.9 Without complications
0.000 0.002 0.998
E70-E90 Metabolic disorders
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.006 0.994
E83.1 Disorders of iron metabolism
0.989 0.011 0.000
E10.4 With neurological complications
0.000 0.017 0.983
E07 Other disorders of thyroid
0.000 0.020 0.980
M45 Ankylosing spondylitis
0.979 0.021 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.974 0.026 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.027 0.973
E07.9 Disorder of thyroid, unspecified
0.000 0.036 0.964
E14.3 With ophthalmic complications
0.000 0.064 0.936
E10.2 With renal complications
0.000 0.069 0.931
G35-G37 Demyelinating diseases of the central nervous system
0.911 0.089 0.000
G37 Other demyelinating diseases of central nervous system
0.894 0.106 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.115 0.885
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.121 0.879
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.129 0.871
E13 Other specified diabetes mellitus
0.000 0.130 0.870
E10.8 With unspecified complications
0.000 0.139 0.861
E10.0 With coma
0.000 0.140 0.860
E10.6 With other specified complications
0.000 0.151 0.849
E74 Other disorders of carbohydrate metabolism
0.000 0.158 0.842
G37.9 Demyelinating disease of central nervous system, unspecified
0.830 0.170 0.000
E78.4 Other hyperlipidaemia
0.000 0.179 0.821
E11.5 With peripheral circulatory complications
0.000 0.179 0.821
G37.8 Other specified demyelinating diseases of central nervous system
0.810 0.190 0.000
E13.9 Without complications
0.000 0.208 0.792
E14.1 With ketoacidosis
0.000 0.208 0.792
H20.9 Iridocyclitis, unspecified
0.781 0.219 0.000
E14.8 With unspecified complications
0.000 0.223 0.777
E40-E46 Malnutrition
0.000 0.227 0.773
E79 Disorders of purine and pyrimidine metabolism
0.000 0.229 0.771
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.231 0.769
E78.6 Lipoprotein deficiency
0.000 0.236 0.764
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.238 0.762
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.240 0.759
E88 Other metabolic disorders
0.000 0.244 0.756
E11.6 With other specified complications
0.000 0.247 0.753
E14.5 With peripheral circulatory complications
0.000 0.250 0.750
E11.0 With coma
0.000 0.253 0.747
E73 Lactose intolerance
0.000 0.253 0.747
E89.3 Postprocedural hypopituitarism
0.000 0.255 0.745
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.742 0.258 0.000
E14.4 With neurological complications
0.000 0.259 0.741
E07.8 Other specified disorders of thyroid
0.000 0.259 0.741
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.259 0.740
M45.X6 Ankylosing spondylitis (Lumbar region)
0.728 0.272 0.000
E89.2 Postprocedural hypoparathyroidism
0.000 0.275 0.725
E05.8 Other thyrotoxicosis
0.000 0.275 0.725
E10.5 With peripheral circulatory complications
0.000 0.280 0.720
M45.X2 Ankylosing spondylitis (Cervical region)
0.717 0.283 0.000
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
E11.7 With multiple complications
0.000 0.284 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.285 0.715
E76 Disorders of glycosaminoglycan metabolism
0.000 0.285 0.715
E72 Other disorders of amino-acid metabolism
0.000 0.285 0.715
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.285 0.715
E70 Disorders of aromatic amino-acid metabolism
0.000 0.285 0.715
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.285 0.715
H20 Iridocyclitis
0.711 0.289 0.000
E07.1 Dyshormogenetic goitre
0.000 0.297 0.703
E07.0 Hypersecretion of calcitonin
0.000 0.297 0.703
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.702 0.298 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.702 0.298 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.702 0.298 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.702 0.298 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.702 0.298 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.702 0.298 0.000
K90 Intestinal malabsorption
0.000 0.308 0.692
E20-E35 Disorders of other endocrine glands
0.000 0.310 0.690
E03.8 Other specified hypothyroidism
0.000 0.313 0.687
E11.1 With ketoacidosis
0.000 0.321 0.678
E11.2 With renal complications
0.000 0.337 0.663
H20.1 Chronic iridocyclitis
0.663 0.337 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.337 0.662
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.340 0.660
E84 Cystic fibrosis
0.000 0.340 0.660
E88.2 Lipomatosis, not elsewhere classified
0.000 0.343 0.657
G36 Other acute disseminated demyelination
0.653 0.347 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.351 0.649
E03.1 Congenital hypothyroidism without goitre
0.000 0.356 0.644
G37.5 Concentric sclerosis [Balo]
0.641 0.359 0.000
G37.4 Subacute necrotising myelitis
0.641 0.359 0.000
G37.2 Central pontine myelinolysis
0.641 0.359 0.000
G37.1 Central demyelination of corpus callosum
0.641 0.359 0.000
G37.0 Diffuse sclerosis
0.641 0.359 0.000
H20.0 Acute and subacute iridocyclitis
0.626 0.374 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.376 0.624
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.376 0.624
E89.5 Postprocedural testicular hypofunction
0.000 0.376 0.624
E89.1 Postprocedural hypoinsulinaemia
0.000 0.376 0.624
E13.8 With unspecified complications
0.000 0.376 0.624
E13.7 With multiple complications
0.000 0.376 0.624
E13.6 With other specified complications
0.000 0.376 0.624
E13.5 With peripheral circulatory complications
0.000 0.376 0.624
E13.4 With neurological complications
0.000 0.376 0.624
E13.2 With renal complications
0.000 0.376 0.624
E13.1 With ketoacidosis
0.000 0.376 0.624
E13.0 With coma
0.000 0.376 0.624
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.383 0.616
E11.3 With ophthalmic complications
0.000 0.384 0.616
E46 Unspecified protein-energy malnutrition
0.000 0.389 0.611
I83.0 Varicose veins of lower extremities with ulcer
0.611 0.389 0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.610 0.390 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.391 0.609
I83 Varicose veins of lower extremities
0.606 0.394 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.396 0.603
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.396 0.603
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.396 0.603
E74.2 Disorders of galactose metabolism
0.000 0.396 0.603
E74.1 Disorders of fructose metabolism
0.000 0.396 0.603
E14.6 With other specified complications
0.000 0.411 0.589
K90.9 Intestinal malabsorption, unspecified
0.000 0.420 0.580
E88.8 Other specified metabolic disorders
0.000 0.422 0.578
E78.1 Pure hyperglyceridaemia
0.000 0.424 0.575
E13.3 With ophthalmic complications
0.000 0.425 0.575
E89.4 Postprocedural ovarian failure
0.000 0.425 0.575
E22 Hyperfunction of pituitary gland
0.000 0.426 0.574
E73.9 Lactose intolerance, unspecified
0.000 0.433 0.567
E11.4 With neurological complications
0.000 0.436 0.564
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.446 0.554
E45 Retarded development following protein-energy malnutrition
0.000 0.446 0.554
E43 Unspecified severe protein-energy malnutrition
0.000 0.446 0.554
E42 Marasmic kwashiorkor
0.000 0.446 0.554
E41 Nutritional marasmus
0.000 0.446 0.554
E40 Kwashiorkor
0.000 0.446 0.554
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.447 0.553
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.447 0.553
E79.1 Lesch-Nyhan syndrome
0.000 0.447 0.553
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.448 0.552
E06 Thyroiditis
0.000 0.453 0.547
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.457 0.543
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.460 0.540
E73.8 Other lactose intolerance
0.000 0.464 0.535
E73.1 Secondary lactase deficiency
0.000 0.464 0.535
E73.0 Congenital lactase deficiency
0.000 0.464 0.535
K90.8 Other intestinal malabsorption
0.000 0.470 0.530
E50-E64 Other nutritional deficiencies
0.000 0.470 0.530
E83 Disorders of mineral metabolism
0.426 0.471 0.103
E74.0 Glycogen storage disease
0.000 0.482 0.517
E25 Adrenogenital disorders
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.487 0.513
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.487 0.513
E70.3 Albinism
0.000 0.487 0.513
E70.2 Disorders of tyrosine metabolism
0.000 0.487 0.513
E70.1 Other hyperphenylalaninaemias
0.000 0.487 0.513
E70.0 Classical phenylketonuria
0.000 0.487 0.513
E71.3 Disorders of fatty-acid metabolism
0.000 0.487 0.513
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.487 0.513
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.487 0.513
E71.0 Maple-syrup-urine disease
0.000 0.487 0.513
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.487 0.513
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.487 0.513
E72.5 Disorders of glycine metabolism
0.000 0.487 0.513
E72.4 Disorders of ornithine metabolism
0.000 0.487 0.513
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.487 0.513
E72.2 Disorders of urea cycle metabolism
0.000 0.487 0.513
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.487 0.513
E72.0 Disorders of amino-acid transport
0.000 0.487 0.513
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.487 0.513
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.487 0.513
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.487 0.513
E76.2 Other mucopolysaccharidoses
0.000 0.487 0.513
E76.1 Mucopolysaccharidosis, type II
0.000 0.487 0.513
E76.0 Mucopolysaccharidosis, type I
0.000 0.487 0.513
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.487 0.513
E77.8 Other disorders of glycoprotein metabolism
0.000 0.487 0.513
E77.1 Defects in glycoprotein degradation
0.000 0.487 0.513
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.487 0.513
H20.2 Lens-induced iridocyclitis
0.510 0.490 0.000
E27 Other disorders of adrenal gland
0.000 0.496 0.504
E88.9 Metabolic disorder, unspecified
0.000 0.500 0.499
K90.3 Pancreatic steatorrhoea
0.000 0.504 0.496
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.504 0.496
K90.1 Tropical sprue
0.000 0.504 0.496
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.505 0.495
E32 Diseases of thymus
0.000 0.505 0.495
E31 Polyglandular dysfunction
0.000 0.505 0.495
E30 Disorders of puberty, not elsewhere classified
0.000 0.505 0.495
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.506 0.494
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.493 0.507 0.000
E24 Cushing's syndrome
0.000 0.513 0.487
E34 Other endocrine disorders
0.000 0.520 0.480
E22.0 Acromegaly and pituitary gigantism
0.000 0.521 0.479
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.523 0.477
E88.3 Tumour lysis syndrome
0.000 0.524 0.475
E15 Nondiabetic hypoglycaemic coma
0.000 0.525 0.475
E84.8 Cystic fibrosis with other manifestations
0.000 0.527 0.473
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.527 0.473
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.527 0.473
E23 Hypofunction and other disorders of pituitary gland
0.000 0.527 0.472
E27.9 Disorder of adrenal gland, unspecified
0.000 0.530 0.470
E20 Hypoparathyroidism
0.000 0.531 0.469
G36.9 Acute disseminated demyelination, unspecified
0.468 0.532 0.000
G36.8 Other specified acute disseminated demyelination
0.468 0.532 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.468 0.532 0.000
G36.0 Neuromyelitis optica [Devic]
0.467 0.533 0.000
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.533 0.467
E75.6 Lipid storage disorder, unspecified
0.000 0.534 0.465
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.534 0.465
E75.3 Sphingolipidosis, unspecified
0.000 0.534 0.465
E75.2 Other sphingolipidosis
0.000 0.534 0.465
E75.1 Other gangliosidosis
0.000 0.534 0.465
E75.0 GM2 gangliosidosis
0.000 0.534 0.465
E78.5 Hyperlipidaemia, unspecified
0.000 0.535 0.465
E61 Deficiency of other nutrient elements
0.000 0.538 0.462
E29 Testicular dysfunction
0.000 0.540 0.460
I83.1 Varicose veins of lower extremities with inflammation
0.459 0.541 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.440 0.560 0.000
E28 Ovarian dysfunction
0.000 0.566 0.434
E85 Amyloidosis
0.001 0.568 0.432
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.569 0.431
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.573 0.427
E26 Hyperaldosteronism
0.000 0.573 0.427
E11.8 With unspecified complications
0.001 0.575 0.425
E21.3 Hyperparathyroidism, unspecified
0.000 0.578 0.421
E16 Other disorders of pancreatic internal secretion
0.000 0.579 0.421
E84.9 Cystic fibrosis, unspecified
0.000 0.583 0.417
E61.1 Iron deficiency
0.000 0.588 0.412
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.588 0.411
E22.8 Other hyperfunction of pituitary gland
0.000 0.588 0.411
H16 Keratitis
0.406 0.594 0.000
E51 Thiamine deficiency
0.000 0.596 0.404
E83.3 Disorders of phosphorus metabolism
0.375 0.599 0.027
E75.5 Other lipid storage disorders
0.000 0.601 0.399
E44.1 Mild protein-energy malnutrition
0.000 0.602 0.397
E44.0 Moderate protein-energy malnutrition
0.000 0.602 0.397
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.606 0.393
H16.0 Corneal ulcer
0.393 0.607 0.000
E06.5 Other chronic thyroiditis
0.000 0.608 0.392
E06.4 Drug-induced thyroiditis
0.000 0.608 0.392
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.608 0.392
E06.1 Subacute thyroiditis
0.000 0.608 0.392
E06.0 Acute thyroiditis
0.000 0.608 0.392
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.612 0.388
E21.4 Other specified disorders of parathyroid gland
0.000 0.612 0.388
E80.2 Other porphyria
0.001 0.616 0.383
E23.6 Other disorders of pituitary gland
0.000 0.619 0.381
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.620 0.380
E63 Other nutritional deficiencies
0.000 0.620 0.380
E50 Vitamin A deficiency
0.000 0.620 0.380
E60 Dietary zinc deficiency
0.000 0.620 0.380
E59 Dietary selenium deficiency
0.000 0.620 0.380
E54 Ascorbic acid deficiency
0.000 0.620 0.380
E52 Niacin deficiency [pellagra]
0.000 0.620 0.380
E83.9 Disorder of mineral metabolism, unspecified
0.305 0.621 0.074
E83.8 Other disorders of mineral metabolism
0.305 0.621 0.074
E83.2 Disorders of zinc metabolism
0.305 0.621 0.074
E83.0 Disorders of copper metabolism
0.305 0.621 0.074
E23.2 Diabetes insipidus
0.000 0.626 0.374
E21.2 Other hyperparathyroidism
0.000 0.626 0.374
E24.2 Drug-induced Cushing's syndrome
0.000 0.627 0.373
E25.9 Adrenogenital disorder, unspecified
0.000 0.629 0.371
E25.8 Other adrenogenital disorders
0.000 0.629 0.371
E80.1 Porphyria cutanea tarda
0.001 0.629 0.371
E34.9 Endocrine disorder, unspecified
0.000 0.629 0.371
H18 Other disorders of cornea
0.367 0.633 0.000
E21.0 Primary hyperparathyroidism
0.000 0.636 0.364
E23.7 Disorder of pituitary gland, unspecified
0.000 0.637 0.363
E27.5 Adrenomedullary hyperfunction
0.000 0.638 0.362
E27.0 Other adrenocortical overactivity
0.000 0.638 0.362
E34.8 Other specified endocrine disorders
0.000 0.638 0.361
E56 Other vitamin deficiencies
0.000 0.640 0.360
E30.9 Disorder of puberty, unspecified
0.000 0.645 0.355
E30.8 Other disorders of puberty
0.000 0.645 0.355
E30.1 Precocious puberty
0.000 0.645 0.355
E30.0 Delayed puberty
0.000 0.645 0.355
E31.9 Polyglandular dysfunction, unspecified
0.000 0.645 0.355
E31.8 Other polyglandular dysfunction
0.000 0.645 0.355
E31.1 Polyglandular hyperfunction
0.000 0.645 0.355
E31.0 Autoimmune polyglandular failure
0.000 0.645 0.355
E32.9 Disease of thymus, unspecified
0.000 0.645 0.355
E32.8 Other diseases of thymus
0.000 0.645 0.355
E32.1 Abscess of thymus
0.000 0.645 0.355
E32.0 Persistent hyperplasia of thymus
0.000 0.645 0.355
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.645 0.355
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.645 0.355
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.645 0.355
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.645 0.354
E80.5 Crigler-Najjar syndrome
0.001 0.645 0.354
E80.3 Defects of catalase and peroxydase
0.001 0.645 0.354
E80.0 Hereditary erythropoietic porphyria
0.001 0.645 0.354
E24.8 Other Cushing's syndrome
0.000 0.651 0.349
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.651 0.349
E24.3 Ectopic ACTH syndrome
0.000 0.651 0.349
E24.1 Nelson's syndrome
0.000 0.651 0.349
H20.8 Other iridocyclitis
0.349 0.651 0.000
E16.1 Other hypoglycaemia
0.000 0.652 0.348
E24.0 Pituitary-dependent Cushing's disease
0.000 0.656 0.344
E34.5 Androgen resistance syndrome
0.000 0.656 0.344
E34.4 Constitutional tall stature
0.000 0.656 0.344
E34.3 Short stature, not elsewhere classified
0.000 0.656 0.344
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.656 0.344
E34.1 Other hypersecretion of intestinal hormones
0.000 0.656 0.344
E06.3 Autoimmune thyroiditis
0.000 0.661 0.339
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.661 0.339
E23.1 Drug-induced hypopituitarism
0.000 0.661 0.339
E27.8 Other specified disorders of adrenal gland
0.000 0.663 0.337
E20.8 Other hypoparathyroidism
0.000 0.664 0.336
E20.1 Pseudohypoparathyroidism
0.000 0.664 0.336
E20.0 Idiopathic hypoparathyroidism
0.000 0.664 0.336
E22.1 Hyperprolactinaemia
0.000 0.665 0.335
E61.2 Magnesium deficiency
0.000 0.665 0.335
H16.8 Other keratitis
0.335 0.665 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.334 0.666 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.668 0.331
E61.8 Deficiency of other specified nutrient elements
0.000 0.668 0.331
E61.7 Deficiency of multiple nutrient elements
0.000 0.668 0.331
E61.6 Vanadium deficiency
0.000 0.668 0.331
E61.5 Molybdenum deficiency
0.000 0.668 0.331
E61.4 Chromium deficiency
0.000 0.668 0.331
E61.3 Manganese deficiency
0.000 0.668 0.331
E61.0 Copper deficiency
0.000 0.668 0.331
E29.9 Testicular dysfunction, unspecified
0.000 0.670 0.330
E29.8 Other testicular dysfunction
0.000 0.670 0.330
E29.0 Testicular hyperfunction
0.000 0.670 0.330
E80.6 Other disorders of bilirubin metabolism
0.001 0.671 0.328
E65-E68 Obesity and other hyperalimentation
0.000 0.672 0.328
E58 Dietary calcium deficiency
0.000 0.674 0.326
H18.1 Bullous keratopathy
0.324 0.676 0.000
E24.9 Cushing's syndrome, unspecified
0.000 0.683 0.317
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.685 0.314
E51.2 Wernicke's encephalopathy
0.000 0.686 0.314
E28.9 Ovarian dysfunction, unspecified
0.000 0.688 0.311
E28.8 Other ovarian dysfunction
0.000 0.688 0.311
E28.1 Androgen excess
0.000 0.688 0.311
E28.0 Oestrogen excess
0.000 0.688 0.311
E20.9 Hypoparathyroidism, unspecified
0.000 0.690 0.310
H18.3 Changes in corneal membranes
0.310 0.690 0.000
E85.8 Other amyloidosis
0.001 0.690 0.309
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.690 0.309
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.690 0.309
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.690 0.309
H18.6 Keratoconus
0.309 0.691 0.000
E26.9 Hyperaldosteronism, unspecified
0.000 0.694 0.306
E26.8 Other hyperaldosteronism
0.000 0.694 0.306
E26.1 Secondary hyperaldosteronism
0.000 0.694 0.306
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.694 0.306
E06.9 Thyroiditis, unspecified
0.000 0.695 0.305
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.698 0.302
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.698 0.302
E16.4 Abnormal secretion of gastrin
0.000 0.698 0.302
E16.3 Increased secretion of glucagon
0.000 0.698 0.302
H17 Corneal scars and opacities
0.301 0.699 0.000
H18.5 Hereditary corneal dystrophies
0.299 0.701 0.000
E89.0 Postprocedural hypothyroidism
0.000 0.701 0.299
E29.1 Testicular hypofunction
0.000 0.705 0.295
H16.4 Corneal neovascularisation
0.291 0.709 0.000
E51.9 Thiamine deficiency, unspecified
0.000 0.710 0.290
E51.8 Other manifestations of thiamine deficiency
0.000 0.710 0.290
E51.1 Beriberi
0.000 0.710 0.290
E28.3 Primary ovarian failure
0.000 0.714 0.286
H16.3 Interstitial and deep keratitis
0.286 0.714 0.000
E85.9 Amyloidosis, unspecified
0.001 0.715 0.284
E28.2 Polycystic ovarian syndrome
0.000 0.717 0.283
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.280 0.720 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.723 0.276
M75.0 Adhesive capsulitis of shoulder
0.000 0.724 0.276
H16.1 Other superficial keratitis without conjunctivitis
0.273 0.727 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.727 0.272
E50.8 Other manifestations of vitamin A deficiency
0.000 0.727 0.272
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.727 0.272
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.727 0.272
E50.5 Vitamin A deficiency with night blindness
0.000 0.727 0.272
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.727 0.272
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.727 0.272
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.727 0.272
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.727 0.272
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.727 0.272
E63.9 Nutritional deficiency, unspecified
0.000 0.727 0.272
E63.8 Other specified nutritional deficiencies
0.000 0.727 0.272
E63.1 Imbalance of constituents of food intake
0.000 0.727 0.272
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.727 0.272
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.727 0.272
E64.8 Sequelae of other nutritional deficiencies
0.000 0.727 0.272
E64.3 Sequelae of rickets
0.000 0.727 0.272
E64.2 Sequelae of vitamin C deficiency
0.000 0.727 0.272
E64.1 Sequelae of vitamin A deficiency
0.000 0.727 0.272
E64.0 Sequelae of protein-energy malnutrition
0.000 0.727 0.272
E34.0 Carcinoid syndrome
0.000 0.736 0.264
H18.7 Other corneal deformities
0.263 0.736 0.000
H15 Disorders of sclera
0.263 0.737 0.000
H18.2 Other corneal oedema
0.261 0.738 0.000
E55 Vitamin D deficiency
0.000 0.741 0.259
E56.9 Vitamin deficiency, unspecified
0.000 0.742 0.258
E56.8 Deficiency of other vitamins
0.000 0.742 0.258
E56.0 Deficiency of vitamin E
0.000 0.742 0.258
H22.1 Iridocyclitis in other diseases classified elsewhere
0.258 0.742 0.000
E85.3 Secondary systemic amyloidosis
0.001 0.746 0.253
H16.2 Keratoconjunctivitis
0.248 0.752 0.000
H18.0 Corneal pigmentations and deposits
0.244 0.756 0.000
H21 Other disorders of iris and ciliary body
0.242 0.758 0.000
H22.8 Other disorders of iris and ciliary body in diseases classified elsewhere
0.239 0.760 0.000
H22.0 Iridocyclitis in infectious and parasitic diseases classified elsewhere
0.239 0.760 0.000
E26.0 Primary hyperaldosteronism
0.000 0.761 0.238
E56.1 Deficiency of vitamin K
0.000 0.762 0.238
E67 Other hyperalimentation
0.000 0.765 0.235
E68 Sequelae of hyperalimentation
0.000 0.765 0.235
H17.8 Other corneal scars and opacities
0.234 0.766 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.770 0.230
E27.2 Addisonian crisis
0.001 0.779 0.221
H18.9 Disorder of cornea, unspecified
0.217 0.783 0.000
H17.1 Other central corneal opacity
0.216 0.784 0.000
H17.0 Adherent leukoma
0.216 0.784 0.000
H18.4 Corneal degeneration
0.213 0.787 0.000
E53 Deficiency of other B group vitamins
0.000 0.790 0.210
H16.9 Keratitis, unspecified
0.209 0.791 0.000
E85.4 Organ-limited amyloidosis
0.001 0.798 0.201
H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
0.202 0.798 0.000
H19.8 Other disorders of sclera and cornea in diseases classified elsewhere
0.201 0.799 0.000
H19.0 Scleritis and episcleritis in diseases classified elsewhere
0.201 0.799 0.000
E83.4 Disorders of magnesium metabolism
0.138 0.803 0.059
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.190 0.810 0.000
H15.9 Disorder of sclera, unspecified
0.189 0.811 0.000
E55.0 Rickets, active
0.000 0.814 0.186
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.178 0.822 0.000
H15.8 Other disorders of sclera
0.178 0.822 0.000
H15.1 Episcleritis
0.178 0.822 0.000
H21.5 Other adhesions and disruptions of iris and ciliary body
0.177 0.823 0.000
H21.0 Hyphaema
0.176 0.824 0.000
H21.4 Pupillary membranes
0.174 0.826 0.000
H17.9 Corneal scar and opacity, unspecified
0.174 0.826 0.000
H21.3 Cyst of iris, ciliary body and anterior chamber
0.174 0.826 0.000
H21.2 Degeneration of iris and ciliary body
0.172 0.828 0.000
E67.8 Other specified hyperalimentation
0.000 0.831 0.169
E67.3 Hypervitaminosis D
0.000 0.831 0.169
E67.2 Megavitamin-B6 syndrome
0.000 0.831 0.169
E67.1 Hypercarotenaemia
0.000 0.831 0.169
E67.0 Hypervitaminosis A
0.000 0.831 0.169
H15.0 Scleritis
0.167 0.833 0.000
E65 Localised adiposity
0.000 0.834 0.166
H21.8 Other specified disorders of iris and ciliary body
0.159 0.840 0.000
H21.9 Disorder of iris and ciliary body, unspecified
0.155 0.845 0.000
E53.1 Pyridoxine deficiency
0.000 0.849 0.151
E53.0 Riboflavin deficiency
0.000 0.849 0.151
H21.1 Other vascular disorders of iris and ciliary body
0.143 0.857 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.860 0.140
H18.8 Other specified disorders of cornea
0.135 0.864 0.001
E16.2 Hypoglycaemia, unspecified
0.000 0.876 0.124
E83.5 Disorders of calcium metabolism
0.101 0.879 0.021
G56.0 Carpal tunnel syndrome
0.000 0.893 0.107
M45-M49 Spondylopathies
0.103 0.897 0.000
E23.0 Hypopituitarism
0.001 0.903 0.096
E86 Volume depletion
0.000 0.907 0.093
E04 Other non-toxic goitre
0.000 0.916 0.083
M48 Other spondylopathies
0.074 0.926 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.069 0.931 0.000
M49 Spondylopathies in diseases classified elsewhere
0.068 0.932 0.000
C18.7 Sigmoid colon
0.000 0.934 0.066
E55.9 Vitamin D deficiency, unspecified
0.000 0.935 0.064

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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