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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2596503
log Bayes Factor = 40.3425
Chromosome 6   position 31,320,810  (GRCh37) Explore rs2596503 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.002 0.998
E10-E14 Diabetes mellitus
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.004 0.996
E83.1 Disorders of iron metabolism
0.996 0.004 0.000
E10.3 With ophthalmic complications
0.000 0.012 0.988
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.987 0.013 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.024 0.976
E05.9 Thyrotoxicosis, unspecified
0.000 0.039 0.961
L40.0 Psoriasis vulgaris
0.000 0.064 0.936
E10.4 With neurological complications
0.000 0.081 0.919
L40-L45 Papulosquamous disorders
0.000 0.089 0.911
G35 Multiple sclerosis
0.890 0.110 0.000
L43 Lichen planus
0.000 0.113 0.887
E07 Other disorders of thyroid
0.000 0.123 0.877
L43.9 Lichen planus, unspecified
0.000 0.132 0.868
E10.2 With renal complications
0.000 0.134 0.866
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.135 0.865
E78.0 Pure hypercholesterolaemia
0.000 0.139 0.861
E70-E90 Metabolic disorders
0.002 0.147 0.851
L40.8 Other psoriasis
0.000 0.151 0.849
E78.5 Hyperlipidaemia, unspecified
0.000 0.159 0.841
E10.1 With ketoacidosis
0.000 0.160 0.840
E07.9 Disorder of thyroid, unspecified
0.000 0.191 0.809
E10.8 With unspecified complications
0.000 0.192 0.808
E13 Other specified diabetes mellitus
0.000 0.200 0.800
E78.8 Other disorders of lipoprotein metabolism
0.000 0.216 0.784
E10.0 With coma
0.000 0.221 0.779
I83 Varicose veins of lower extremities
0.776 0.224 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.253 0.747
I83.0 Varicose veins of lower extremities with ulcer
0.745 0.255 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.263 0.737
E14 Unspecified diabetes mellitus
0.000 0.271 0.729
E03.8 Other specified hypothyroidism
0.000 0.276 0.723
L42 Pityriasis rosea
0.000 0.277 0.723
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.284 0.716
E03.4 Atrophy of thyroid (acquired)
0.000 0.284 0.716
E03.3 Postinfectious hypothyroidism
0.000 0.284 0.716
E03.1 Congenital hypothyroidism without goitre
0.000 0.284 0.716
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
E12 Malnutrition-related diabetes mellitus
0.000 0.285 0.715
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.290 0.710
E78.1 Pure hyperglyceridaemia
0.000 0.296 0.704
E05.5 Thyroid crisis or storm
0.000 0.300 0.700
E05.4 Thyrotoxicosis factitia
0.000 0.300 0.700
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.300 0.700
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.300 0.700
E10.6 With other specified complications
0.000 0.309 0.690
E05.8 Other thyrotoxicosis
0.000 0.324 0.676
G35-G37 Demyelinating diseases of the central nervous system
0.666 0.334 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.338 0.662
L43.8 Other lichen planus
0.000 0.341 0.659
E13.9 Without complications
0.000 0.342 0.658
L44 Other papulosquamous disorders
0.000 0.346 0.653
L41 Parapsoriasis
0.000 0.346 0.653
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.346 0.653
L40.3 Pustulosis palmaris et plantaris
0.000 0.360 0.639
L43.3 Subacute (active) lichen planus
0.000 0.364 0.636
L43.2 Lichenoid drug reaction
0.000 0.364 0.636
L43.1 Bullous lichen planus
0.000 0.364 0.636
L43.0 Hypertrophic lichen planus
0.000 0.364 0.636
E07.1 Dyshormogenetic goitre
0.000 0.371 0.629
E07.0 Hypersecretion of calcitonin
0.000 0.371 0.629
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.629 0.371 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.375 0.625
G37 Other demyelinating diseases of central nervous system
0.621 0.379 0.000
E78.6 Lipoprotein deficiency
0.000 0.380 0.620
E78.3 Hyperchylomicronaemia
0.000 0.380 0.620
E14.3 With ophthalmic complications
0.000 0.382 0.618
E20-E35 Disorders of other endocrine glands
0.000 0.384 0.616
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.387 0.612
E77 Disorders of glycoprotein metabolism
0.002 0.389 0.610
E76 Disorders of glycosaminoglycan metabolism
0.002 0.389 0.610
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.389 0.610
E72 Other disorders of amino-acid metabolism
0.002 0.389 0.610
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.389 0.610
E70 Disorders of aromatic amino-acid metabolism
0.002 0.389 0.610
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.389 0.610
E11 Non-insulin-dependent diabetes mellitus
0.000 0.395 0.605
E40-E46 Malnutrition
0.000 0.401 0.599
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.403 0.597
E84 Cystic fibrosis
0.001 0.403 0.595
E10.5 With peripheral circulatory complications
0.000 0.412 0.587
E74 Other disorders of carbohydrate metabolism
0.001 0.414 0.585
E13.8 With unspecified complications
0.000 0.426 0.573
E13.7 With multiple complications
0.000 0.426 0.573
E13.6 With other specified complications
0.000 0.426 0.573
E13.5 With peripheral circulatory complications
0.000 0.426 0.573
E13.4 With neurological complications
0.000 0.426 0.573
E13.3 With ophthalmic complications
0.000 0.426 0.573
E13.2 With renal complications
0.000 0.426 0.573
E13.1 With ketoacidosis
0.000 0.426 0.573
E13.0 With coma
0.000 0.426 0.573
E11.1 With ketoacidosis
0.000 0.428 0.572
G37.9 Demyelinating disease of central nervous system, unspecified
0.564 0.436 0.000
E07.8 Other specified disorders of thyroid
0.000 0.440 0.560
E23 Hypofunction and other disorders of pituitary gland
0.000 0.448 0.552
E79 Disorders of purine and pyrimidine metabolism
0.002 0.450 0.548
E14.1 With ketoacidosis
0.000 0.454 0.546
E89.3 Postprocedural hypopituitarism
0.000 0.455 0.545
E78.4 Other hyperlipidaemia
0.000 0.459 0.541
E85 Amyloidosis
0.001 0.469 0.530
E83 Disorders of mineral metabolism
0.164 0.471 0.366
G37.8 Other specified demyelinating diseases of central nervous system
0.527 0.473 0.000
E14.8 With unspecified complications
0.000 0.477 0.523
E14.7 With multiple complications
0.000 0.477 0.523
E14.2 Withrenal complications
0.000 0.477 0.523
E14.0 With coma
0.000 0.477 0.523
E06 Thyroiditis
0.000 0.477 0.523
E50-E64 Other nutritional deficiencies
0.000 0.479 0.521
E14.5 With peripheral circulatory complications
0.000 0.479 0.521
E73 Lactose intolerance
0.002 0.483 0.515
E24 Cushing's syndrome
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.513
E12.9 Without complications
0.000 0.487 0.513
E12.8 With unspecified complications
0.000 0.487 0.513
E12.7 With multiple complications
0.000 0.487 0.513
E12.6 With other specified complications
0.000 0.487 0.513
E12.5 With peripheral circulatory complications
0.000 0.487 0.513
E12.4 With neurological complications
0.000 0.487 0.513
E12.3 With ophthalmic complications
0.000 0.487 0.513
E12.2 With renal complications
0.000 0.487 0.513
E12.1 With ketoacidosis
0.000 0.487 0.513
E12.0 With coma
0.000 0.487 0.513
J45.9 Asthma, unspecified
0.000 0.487 0.513
E14.4 With neurological complications
0.000 0.488 0.512
E14.6 With other specified complications
0.000 0.490 0.510
E15 Nondiabetic hypoglycaemic coma
0.000 0.491 0.509
E11.0 With coma
0.000 0.492 0.508
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.492 0.508
E16 Other disorders of pancreatic internal secretion
0.000 0.495 0.505
E11.2 With renal complications
0.000 0.495 0.504
E11.6 With other specified complications
0.000 0.514 0.486
G36 Other acute disseminated demyelination
0.478 0.522 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.529 0.471
L41.9 Parapsoriasis, unspecified
0.000 0.531 0.469
L41.8 Other parapsoriasis
0.000 0.531 0.469
L41.5 Retiform parapsoriasis
0.000 0.531 0.469
L41.4 Large plaque parapsoriasis
0.000 0.531 0.469
L41.3 Small plaque parapsoriasis
0.000 0.531 0.469
L41.2 Lymphomatoid papulosis
0.000 0.531 0.469
L41.1 Pityriasis lichenoides chronica
0.000 0.531 0.469
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.531 0.469
L44.9 Papulosquamous disorder, unspecified
0.000 0.531 0.469
L44.8 Other specified papulosquamous disorders
0.000 0.531 0.469
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.531 0.469
L44.3 Lichen ruber moniliformis
0.000 0.531 0.469
L44.2 Lichen striatus
0.000 0.531 0.469
L44.1 Lichen nitidus
0.000 0.531 0.469
L44.0 Pityriasis rubra pilaris
0.000 0.531 0.469
E21.3 Hyperparathyroidism, unspecified
0.000 0.540 0.460
E23.2 Diabetes insipidus
0.000 0.541 0.459
E23.7 Disorder of pituitary gland, unspecified
0.000 0.546 0.454
G37.5 Concentric sclerosis [Balo]
0.445 0.554 0.000
G37.4 Subacute necrotising myelitis
0.445 0.554 0.000
G37.2 Central pontine myelinolysis
0.445 0.554 0.000
G37.1 Central demyelination of corpus callosum
0.445 0.554 0.000
G37.0 Diffuse sclerosis
0.445 0.554 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.558 0.442
E32 Diseases of thymus
0.000 0.558 0.442
E31 Polyglandular dysfunction
0.000 0.558 0.442
E30 Disorders of puberty, not elsewhere classified
0.000 0.558 0.442
E25 Adrenogenital disorders
0.000 0.558 0.442
E24.9 Cushing's syndrome, unspecified
0.000 0.560 0.440
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.561 0.439
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.561 0.439
E89.5 Postprocedural testicular hypofunction
0.000 0.561 0.439
E89.1 Postprocedural hypoinsulinaemia
0.000 0.561 0.439
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.562 0.437
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.562 0.437
E70.3 Albinism
0.001 0.562 0.437
E70.2 Disorders of tyrosine metabolism
0.001 0.562 0.437
E70.1 Other hyperphenylalaninaemias
0.001 0.562 0.437
E70.0 Classical phenylketonuria
0.001 0.562 0.437
E71.3 Disorders of fatty-acid metabolism
0.001 0.562 0.437
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.562 0.437
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.562 0.437
E71.0 Maple-syrup-urine disease
0.001 0.562 0.437
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.562 0.437
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.562 0.437
E72.5 Disorders of glycine metabolism
0.001 0.562 0.437
E72.4 Disorders of ornithine metabolism
0.001 0.562 0.437
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.562 0.437
E72.2 Disorders of urea cycle metabolism
0.001 0.562 0.437
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.562 0.437
E72.0 Disorders of amino-acid transport
0.001 0.562 0.437
E75.6 Lipid storage disorder, unspecified
0.001 0.562 0.437
E75.5 Other lipid storage disorders
0.001 0.562 0.437
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.562 0.437
E75.3 Sphingolipidosis, unspecified
0.001 0.562 0.437
E75.2 Other sphingolipidosis
0.001 0.562 0.437
E75.1 Other gangliosidosis
0.001 0.562 0.437
E75.0 GM2 gangliosidosis
0.001 0.562 0.437
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.562 0.437
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.562 0.437
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.562 0.437
E76.2 Other mucopolysaccharidoses
0.001 0.562 0.437
E76.1 Mucopolysaccharidosis, type II
0.001 0.562 0.437
E76.0 Mucopolysaccharidosis, type I
0.001 0.562 0.437
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.562 0.437
E77.8 Other disorders of glycoprotein metabolism
0.001 0.562 0.437
E77.1 Defects in glycoprotein degradation
0.001 0.562 0.437
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.562 0.437
E89.4 Postprocedural ovarian failure
0.000 0.563 0.436
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.435 0.565 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.565 0.434
E11.7 With multiple complications
0.000 0.566 0.434
E23.6 Other disorders of pituitary gland
0.000 0.568 0.432
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.570 0.430
E45 Retarded development following protein-energy malnutrition
0.000 0.570 0.430
E43 Unspecified severe protein-energy malnutrition
0.000 0.570 0.430
E42 Marasmic kwashiorkor
0.000 0.570 0.430
E41 Nutritional marasmus
0.000 0.570 0.430
E40 Kwashiorkor
0.000 0.570 0.430
E89.2 Postprocedural hypoparathyroidism
0.000 0.571 0.429
E84.8 Cystic fibrosis with other manifestations
0.001 0.572 0.427
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.572 0.427
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.572 0.427
E26 Hyperaldosteronism
0.000 0.579 0.421
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.579 0.419
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.579 0.419
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.579 0.419
E74.2 Disorders of galactose metabolism
0.001 0.579 0.419
E74.1 Disorders of fructose metabolism
0.001 0.579 0.419
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.582 0.418
E84.9 Cystic fibrosis, unspecified
0.001 0.587 0.412
E80 Disorders of porphyrin and bilirubin metabolism
0.002 0.593 0.406
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.593 0.407
E28 Ovarian dysfunction
0.000 0.595 0.405
E29 Testicular dysfunction
0.000 0.597 0.402
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.604 0.396
E23.1 Drug-induced hypopituitarism
0.000 0.604 0.396
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.605 0.393
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.605 0.393
E79.1 Lesch-Nyhan syndrome
0.001 0.605 0.393
E23.0 Hypopituitarism
0.000 0.606 0.394
E65-E68 Obesity and other hyperalimentation
0.000 0.607 0.393
E16.1 Other hypoglycaemia
0.000 0.609 0.391
E85.9 Amyloidosis, unspecified
0.001 0.618 0.381
E85.8 Other amyloidosis
0.001 0.619 0.380
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.619 0.380
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.619 0.380
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.619 0.380
E20 Hypoparathyroidism
0.000 0.620 0.380
E55 Vitamin D deficiency
0.000 0.620 0.380
E83.9 Disorder of mineral metabolism, unspecified
0.117 0.620 0.262
E83.8 Other disorders of mineral metabolism
0.117 0.620 0.262
E83.2 Disorders of zinc metabolism
0.117 0.620 0.262
E83.0 Disorders of copper metabolism
0.117 0.620 0.262
E74.0 Glycogen storage disease
0.001 0.623 0.376
E06.5 Other chronic thyroiditis
0.000 0.625 0.375
E06.4 Drug-induced thyroiditis
0.000 0.625 0.375
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.625 0.375
E06.1 Subacute thyroiditis
0.000 0.625 0.375
E06.0 Acute thyroiditis
0.000 0.625 0.375
E14.9 Without complications
0.000 0.626 0.374
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.626 0.373
E63 Other nutritional deficiencies
0.000 0.626 0.373
E56 Other vitamin deficiencies
0.000 0.626 0.373
E51 Thiamine deficiency
0.000 0.626 0.373
E50 Vitamin A deficiency
0.000 0.626 0.373
E60 Dietary zinc deficiency
0.000 0.626 0.373
E59 Dietary selenium deficiency
0.000 0.626 0.373
E58 Dietary calcium deficiency
0.000 0.626 0.373
E54 Ascorbic acid deficiency
0.000 0.626 0.373
E52 Niacin deficiency [pellagra]
0.000 0.626 0.373
E22 Hyperfunction of pituitary gland
0.000 0.628 0.372
E73.8 Other lactose intolerance
0.001 0.629 0.369
E73.1 Secondary lactase deficiency
0.001 0.629 0.369
E73.0 Congenital lactase deficiency
0.001 0.629 0.369
E24.8 Other Cushing's syndrome
0.000 0.632 0.368
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.632 0.368
E24.3 Ectopic ACTH syndrome
0.000 0.632 0.368
E24.2 Drug-induced Cushing's syndrome
0.000 0.632 0.368
E24.1 Nelson's syndrome
0.000 0.632 0.368
E24.0 Pituitary-dependent Cushing's disease
0.000 0.632 0.368
E61 Deficiency of other nutrient elements
0.000 0.633 0.367
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.636 0.364
E21.4 Other specified disorders of parathyroid gland
0.000 0.636 0.364
E21.2 Other hyperparathyroidism
0.000 0.636 0.364
E85.3 Secondary systemic amyloidosis
0.001 0.637 0.361
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.638 0.362
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.638 0.362
E16.4 Abnormal secretion of gastrin
0.000 0.638 0.362
E16.3 Increased secretion of glucagon
0.000 0.638 0.362
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.648 0.352
E83.4 Disorders of magnesium metabolism
0.026 0.650 0.324
E11.3 With ophthalmic complications
0.000 0.650 0.350
E34 Other endocrine disorders
0.000 0.657 0.343
G36.9 Acute disseminated demyelination, unspecified
0.343 0.657 0.000
G36.8 Other specified acute disseminated demyelination
0.343 0.657 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.343 0.657 0.000
G36.0 Neuromyelitis optica [Devic]
0.343 0.657 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.002 0.667 0.332
E85.4 Organ-limited amyloidosis
0.001 0.676 0.323
E06.9 Thyroiditis, unspecified
0.000 0.679 0.321
E11.8 With unspecified complications
0.000 0.683 0.317
E25.9 Adrenogenital disorder, unspecified
0.000 0.683 0.317
E25.8 Other adrenogenital disorders
0.000 0.683 0.317
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.683 0.317
E30.9 Disorder of puberty, unspecified
0.000 0.683 0.317
E30.8 Other disorders of puberty
0.000 0.683 0.317
E30.1 Precocious puberty
0.000 0.683 0.317
E30.0 Delayed puberty
0.000 0.683 0.317
E31.9 Polyglandular dysfunction, unspecified
0.000 0.683 0.317
E31.8 Other polyglandular dysfunction
0.000 0.683 0.317
E31.1 Polyglandular hyperfunction
0.000 0.683 0.317
E31.0 Autoimmune polyglandular failure
0.000 0.683 0.317
E32.9 Disease of thymus, unspecified
0.000 0.683 0.317
E32.8 Other diseases of thymus
0.000 0.683 0.317
E32.1 Abscess of thymus
0.000 0.683 0.317
E32.0 Persistent hyperplasia of thymus
0.000 0.683 0.317
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.683 0.317
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.683 0.317
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.683 0.317
E46 Unspecified protein-energy malnutrition
0.000 0.685 0.314
I83.1 Varicose veins of lower extremities with inflammation
0.314 0.686 0.000
M45 Ankylosing spondylitis
0.000 0.689 0.311
E80.6 Other disorders of bilirubin metabolism
0.001 0.691 0.308
E44.1 Mild protein-energy malnutrition
0.000 0.692 0.308
E44.0 Moderate protein-energy malnutrition
0.000 0.692 0.308
E26.9 Hyperaldosteronism, unspecified
0.000 0.698 0.302
E26.8 Other hyperaldosteronism
0.000 0.698 0.302
E26.1 Secondary hyperaldosteronism
0.000 0.698 0.302
K90 Intestinal malabsorption
0.000 0.698 0.302
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.703 0.297
E21.0 Primary hyperparathyroidism
0.000 0.704 0.296
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.708 0.291
E80.5 Crigler-Najjar syndrome
0.001 0.708 0.291
E80.3 Defects of catalase and peroxydase
0.001 0.708 0.291
E80.2 Other porphyria
0.001 0.708 0.291
E80.0 Hereditary erythropoietic porphyria
0.001 0.708 0.291
E28.9 Ovarian dysfunction, unspecified
0.000 0.710 0.290
E28.8 Other ovarian dysfunction
0.000 0.710 0.290
E28.1 Androgen excess
0.000 0.710 0.290
E28.0 Oestrogen excess
0.000 0.710 0.290
E29.9 Testicular dysfunction, unspecified
0.000 0.711 0.289
E29.8 Other testicular dysfunction
0.000 0.711 0.289
E29.0 Testicular hyperfunction
0.000 0.711 0.289
E78.9 Disorder of lipoprotein metabolism, unspecified
0.001 0.713 0.287
E83.3 Disorders of phosphorus metabolism
0.118 0.714 0.168
E28.3 Primary ovarian failure
0.000 0.717 0.283
E67 Other hyperalimentation
0.000 0.718 0.282
E68 Sequelae of hyperalimentation
0.000 0.718 0.282
E26.0 Primary hyperaldosteronism
0.000 0.719 0.281
E55.9 Vitamin D deficiency, unspecified
0.000 0.721 0.279
E61.2 Magnesium deficiency
0.000 0.723 0.277
E73.9 Lactose intolerance, unspecified
0.002 0.724 0.274
E80.1 Porphyria cutanea tarda
0.002 0.726 0.273
E88 Other metabolic disorders
0.003 0.726 0.272
E20.8 Other hypoparathyroidism
0.000 0.727 0.273
E20.1 Pseudohypoparathyroidism
0.000 0.727 0.273
E20.0 Idiopathic hypoparathyroidism
0.000 0.727 0.273
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.727 0.273
E06.3 Autoimmune thyroiditis
0.000 0.727 0.273
E55.0 Rickets, active
0.000 0.727 0.272
E50.9 Vitamin A deficiency, unspecified
0.000 0.732 0.268
E50.8 Other manifestations of vitamin A deficiency
0.000 0.732 0.268
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.732 0.268
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.732 0.268
E50.5 Vitamin A deficiency with night blindness
0.000 0.732 0.268
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.732 0.268
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.732 0.268
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.732 0.268
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.732 0.268
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.732 0.268
E51.9 Thiamine deficiency, unspecified
0.000 0.732 0.268
E51.8 Other manifestations of thiamine deficiency
0.000 0.732 0.268
E51.2 Wernicke's encephalopathy
0.000 0.732 0.268
E51.1 Beriberi
0.000 0.732 0.268
E56.9 Vitamin deficiency, unspecified
0.000 0.732 0.268
E56.8 Deficiency of other vitamins
0.000 0.732 0.268
E56.1 Deficiency of vitamin K
0.000 0.732 0.268
E56.0 Deficiency of vitamin E
0.000 0.732 0.268
E63.9 Nutritional deficiency, unspecified
0.000 0.732 0.268
E63.8 Other specified nutritional deficiencies
0.000 0.732 0.268
E63.1 Imbalance of constituents of food intake
0.000 0.732 0.268
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.732 0.268
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.732 0.268
E64.8 Sequelae of other nutritional deficiencies
0.000 0.732 0.268
E64.3 Sequelae of rickets
0.000 0.732 0.268
E64.2 Sequelae of vitamin C deficiency
0.000 0.732 0.268
E64.1 Sequelae of vitamin A deficiency
0.000 0.732 0.268
E64.0 Sequelae of protein-energy malnutrition
0.000 0.732 0.268
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.733 0.267
E22.8 Other hyperfunction of pituitary gland
0.000 0.733 0.267
E11.5 With peripheral circulatory complications
0.000 0.735 0.265
E61.9 Deficiency of nutrient element, unspecified
0.000 0.736 0.263
E61.8 Deficiency of other specified nutrient elements
0.000 0.736 0.263
E61.7 Deficiency of multiple nutrient elements
0.000 0.736 0.263
E61.6 Vanadium deficiency
0.000 0.736 0.263
E61.5 Molybdenum deficiency
0.000 0.736 0.263
E61.4 Chromium deficiency
0.000 0.736 0.263
E61.3 Manganese deficiency
0.000 0.736 0.263
E61.0 Copper deficiency
0.000 0.736 0.263
E28.2 Polycystic ovarian syndrome
0.000 0.737 0.263
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.745 0.255
E29.1 Testicular hypofunction
0.000 0.751 0.249
E34.0 Carcinoid syndrome
0.000 0.751 0.248
E34.5 Androgen resistance syndrome
0.000 0.754 0.246
E34.4 Constitutional tall stature
0.000 0.754 0.246
E34.3 Short stature, not elsewhere classified
0.000 0.754 0.246
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.754 0.246
E34.1 Other hypersecretion of intestinal hormones
0.000 0.754 0.246
E65 Localised adiposity
0.000 0.757 0.243
E61.1 Iron deficiency
0.000 0.759 0.241
E16.2 Hypoglycaemia, unspecified
0.000 0.764 0.236
E22.1 Hyperprolactinaemia
0.000 0.766 0.234
E34.8 Other specified endocrine disorders
0.000 0.773 0.227
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.777 0.223
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.777 0.223
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.777 0.223
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.777 0.223
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.777 0.223
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.777 0.223
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.777 0.223
K90.3 Pancreatic steatorrhoea
0.000 0.783 0.217
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.783 0.217
K90.1 Tropical sprue
0.000 0.783 0.217
K90.8 Other intestinal malabsorption
0.000 0.788 0.211
E20.9 Hypoparathyroidism, unspecified
0.000 0.789 0.211
E88.2 Lipomatosis, not elsewhere classified
0.002 0.793 0.205
E27 Other disorders of adrenal gland
0.001 0.796 0.203
E67.8 Other specified hyperalimentation
0.000 0.798 0.202
E67.3 Hypervitaminosis D
0.000 0.798 0.202
E67.2 Megavitamin-B6 syndrome
0.000 0.798 0.202
E67.1 Hypercarotenaemia
0.000 0.798 0.202
E67.0 Hypervitaminosis A
0.000 0.798 0.202
E88.9 Metabolic disorder, unspecified
0.002 0.803 0.195
E88.8 Other specified metabolic disorders
0.002 0.803 0.195
K90.9 Intestinal malabsorption, unspecified
0.000 0.803 0.197
E22.0 Acromegaly and pituitary gigantism
0.000 0.812 0.188
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.815 0.185
E53 Deficiency of other B group vitamins
0.001 0.820 0.179
E34.9 Endocrine disorder, unspecified
0.000 0.823 0.176
E88.3 Tumour lysis syndrome
0.002 0.835 0.163
E27.9 Disorder of adrenal gland, unspecified
0.000 0.837 0.163
E11.4 With neurological complications
0.000 0.837 0.162
C83.3 Large cell (diffuse)
0.000 0.843 0.157
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.847 0.153
C85.1 B-cell lymphoma, unspecified
0.000 0.853 0.147
E27.5 Adrenomedullary hyperfunction
0.001 0.854 0.146
E27.3 Drug-induced adrenocortical insufficiency
0.001 0.854 0.146
E27.0 Other adrenocortical overactivity
0.001 0.854 0.146
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.854 0.146
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.856 0.144
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.858 0.142
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.861 0.139
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.866 0.134
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.866 0.134
E53.1 Pyridoxine deficiency
0.001 0.871 0.128
E53.0 Riboflavin deficiency
0.001 0.871 0.128
E88.1 Lipodystrophy, not elsewhere classified
0.003 0.871 0.126
E83.5 Disorders of calcium metabolism
0.072 0.875 0.053
E11.9 Without complications
0.000 0.877 0.123
C82.2 Large cell, follicular
0.000 0.887 0.112
E27.8 Other specified disorders of adrenal gland
0.001 0.888 0.111
E89.0 Postprocedural hypothyroidism
0.000 0.889 0.111
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.890 0.110
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.110 0.890 0.000
C81 Hodgkin's disease
0.000 0.891 0.109
C82.3 Follicular lymphoma grade IIIa
0.000 0.892 0.108
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.895 0.105
C85.0 Lymphosarcoma
0.000 0.895 0.105
C83.7 Burkitt's tumour
0.000 0.898 0.102
E53.9 Vitamin B deficiency, unspecified
0.001 0.898 0.101
E86 Volume depletion
0.000 0.899 0.101
C82.6 Cutaneous follicle centre lymphoma
0.000 0.900 0.100
C82.5 Diffuse follicle centre lymphoma
0.000 0.900 0.100
Z83.7 Family history of diseases of the digestive system
0.000 0.902 0.098
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.000 0.903 0.097
C83.6 Undifferentiated (diffuse)
0.000 0.903 0.096
C83.5 Lymphoblastic (diffuse)
0.000 0.903 0.096
C83.4 Immunoblastic (diffuse)
0.000 0.903 0.096
C83.2 Mixed small and large cell (diffuse)
0.000 0.903 0.096
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.903 0.096
C86 Other specified types of T/NK-cell lymphoma
0.000 0.903 0.096
C82.4 Follicular lymphoma grade IIIb
0.000 0.904 0.096
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.002 0.904 0.093
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.905 0.095

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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