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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2621336
log Bayes Factor = 29.4022
Chromosome 6   position 32,776,976  (GRCh37) Explore rs2621336 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
L40 Psoriasis
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
C44.7 Skin of lower limb, including hip
0.000 0.001 0.999
E20-E35 Disorders of other endocrine glands
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.002 0.998
C44.6 Skin of upper limb, including shoulder
0.000 0.002 0.998
L40.9 Psoriasis, unspecified
0.000 0.002 0.998
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
C44.3 Skin of other and unspecified parts of face
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.006 0.994
E23 Hypofunction and other disorders of pituitary gland
0.000 0.014 0.986
L57.0 Actinic keratosis
0.000 0.015 0.985
C44.4 Skin of scalp and neck
0.000 0.018 0.982
E27 Other disorders of adrenal gland
0.000 0.031 0.969
G35-G37 Demyelinating diseases of the central nervous system
0.965 0.035 0.000
G37 Other demyelinating diseases of central nervous system
0.953 0.047 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.060 0.940
C44.2 Skin of ear and external auricular canal
0.000 0.063 0.937
E10.9 Without complications
0.000 0.064 0.936
G37.9 Demyelinating disease of central nervous system, unspecified
0.932 0.068 0.000
J45.9 Asthma, unspecified
0.931 0.069 0.000
E23.6 Other disorders of pituitary gland
0.000 0.073 0.927
E27.1 Primary adrenocortical insufficiency
0.000 0.074 0.926
E10.2 With renal complications
0.000 0.082 0.918
E10.5 With peripheral circulatory complications
0.000 0.089 0.911
E10.1 With ketoacidosis
0.000 0.101 0.899
E24 Cushing's syndrome
0.000 0.107 0.893
G37.8 Other specified demyelinating diseases of central nervous system
0.874 0.126 0.000
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.130 0.870
L40-L45 Papulosquamous disorders
0.000 0.144 0.856
J45 Asthma
0.852 0.148 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.157 0.843
J45.0 Predominantly allergic asthma
0.830 0.170 0.000
L40.1 Generalised pustular psoriasis
0.000 0.171 0.829
L40.3 Pustulosis palmaris et plantaris
0.000 0.171 0.829
E83.1 Disorders of iron metabolism
0.817 0.183 0.000
E28 Ovarian dysfunction
0.000 0.185 0.815
C44.0 Skin of lip
0.000 0.201 0.799
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.203 0.796
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.210 0.790
E23.0 Hypopituitarism
0.000 0.211 0.789
M07.3 Other psoriatic arthropathies
0.000 0.211 0.789
G36 Other acute disseminated demyelination
0.787 0.213 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.214 0.786
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.218 0.782
E10.0 With coma
0.000 0.220 0.780
E06 Thyroiditis
0.000 0.222 0.778
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.224 0.776
L40.4 Guttate psoriasis
0.000 0.229 0.771
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.233 0.767
E10.4 With neurological complications
0.000 0.234 0.766
E11 Non-insulin-dependent diabetes mellitus
0.000 0.245 0.755
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.246 0.754
E29 Testicular dysfunction
0.000 0.248 0.752
L40.0 Psoriasis vulgaris
0.000 0.252 0.748
E24.0 Pituitary-dependent Cushing's disease
0.000 0.261 0.739
E26 Hyperaldosteronism
0.000 0.262 0.738
L43 Lichen planus
0.000 0.265 0.735
E24.2 Drug-induced Cushing's syndrome
0.000 0.268 0.732
E13 Other specified diabetes mellitus
0.000 0.269 0.731
E11.3 With ophthalmic complications
0.000 0.270 0.730
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.275 0.725
C44.8 Overlapping lesion of skin
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.284 0.716
E32 Diseases of thymus
0.000 0.284 0.716
E31 Polyglandular dysfunction
0.000 0.284 0.716
E30 Disorders of puberty, not elsewhere classified
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.286 0.714
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.293 0.707
E23.1 Drug-induced hypopituitarism
0.000 0.293 0.707
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.293 0.707
E24.9 Cushing's syndrome, unspecified
0.000 0.301 0.699
E27.5 Adrenomedullary hyperfunction
0.000 0.305 0.695
E27.0 Other adrenocortical overactivity
0.000 0.305 0.695
E27.9 Disorder of adrenal gland, unspecified
0.000 0.313 0.687
E21.3 Hyperparathyroidism, unspecified
0.000 0.313 0.687
G37.5 Concentric sclerosis [Balo]
0.683 0.316 0.000
G37.4 Subacute necrotising myelitis
0.683 0.316 0.000
G37.2 Central pontine myelinolysis
0.683 0.316 0.000
G37.1 Central demyelination of corpus callosum
0.683 0.316 0.000
G37.0 Diffuse sclerosis
0.683 0.316 0.000
E25 Adrenogenital disorders
0.000 0.327 0.673
E06.3 Autoimmune thyroiditis
0.000 0.328 0.672
E34 Other endocrine disorders
0.000 0.332 0.668
E28.2 Polycystic ovarian syndrome
0.000 0.332 0.668
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.334 0.666
E05.8 Other thyrotoxicosis
0.000 0.337 0.663
E65-E68 Obesity and other hyperalimentation
0.000 0.338 0.662
G36.0 Neuromyelitis optica [Devic]
0.660 0.340 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.341 0.659
E40-E46 Malnutrition
0.000 0.346 0.653
J45.8 Mixed asthma
0.651 0.349 0.000
E24.8 Other Cushing's syndrome
0.000 0.359 0.640
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.359 0.640
E24.3 Ectopic ACTH syndrome
0.000 0.359 0.640
E24.1 Nelson's syndrome
0.000 0.359 0.640
E70-E90 Metabolic disorders
0.000 0.364 0.636
J45.1 Nonallergic asthma
0.635 0.365 0.000
E10.6 With other specified complications
0.000 0.365 0.635
E23.2 Diabetes insipidus
0.000 0.365 0.635
L43.9 Lichen planus, unspecified
0.000 0.373 0.627
L57.5 Actinic granuloma
0.000 0.376 0.624
L57.3 Poikiloderma of Civatte
0.000 0.376 0.624
L57.2 Cutis rhomboidalis nuchae
0.000 0.376 0.624
L57.1 Actinic reticuloid
0.000 0.376 0.624
E27.8 Other specified disorders of adrenal gland
0.000 0.378 0.622
E11.2 With renal complications
0.000 0.381 0.619
L44 Other papulosquamous disorders
0.000 0.386 0.613
L41 Parapsoriasis
0.000 0.386 0.613
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.386 0.613
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.388 0.612
E27.2 Addisonian crisis
0.000 0.388 0.611
E20 Hypoparathyroidism
0.000 0.389 0.611
E28.3 Primary ovarian failure
0.000 0.391 0.609
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.396 0.604
E04 Other non-toxic goitre
0.000 0.396 0.604
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.399 0.601
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.400 0.600
E11.0 With coma
0.000 0.401 0.599
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.595 0.404 0.000
E28.9 Ovarian dysfunction, unspecified
0.000 0.415 0.584
E28.8 Other ovarian dysfunction
0.000 0.415 0.584
E28.1 Androgen excess
0.000 0.415 0.584
E28.0 Oestrogen excess
0.000 0.415 0.584
E10.8 With unspecified complications
0.000 0.416 0.584
E16 Other disorders of pancreatic internal secretion
0.000 0.422 0.578
E29.1 Testicular hypofunction
0.000 0.425 0.575
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.425 0.574
E89.0 Postprocedural hypothyroidism
0.000 0.428 0.572
E06.5 Other chronic thyroiditis
0.000 0.429 0.571
L43.8 Other lichen planus
0.000 0.430 0.570
E65 Localised adiposity
0.000 0.431 0.569
E78.2 Mixed hyperlipidaemia
0.000 0.431 0.569
E21.4 Other specified disorders of parathyroid gland
0.000 0.434 0.566
M07.38 Other psoriatic arthropathies (Other)
0.000 0.434 0.566
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.434 0.566
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.434 0.566
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.434 0.566
G36.9 Acute disseminated demyelination, unspecified
0.564 0.436 0.000
G36.8 Other specified acute disseminated demyelination
0.564 0.436 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.564 0.436 0.000
E21.2 Other hyperparathyroidism
0.000 0.437 0.562
E06.9 Thyroiditis, unspecified
0.000 0.438 0.562
E78.5 Hyperlipidaemia, unspecified
0.000 0.441 0.559
E06.4 Drug-induced thyroiditis
0.000 0.442 0.558
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.442 0.558
E06.0 Acute thyroiditis
0.000 0.442 0.558
L55 Sunburn
0.000 0.444 0.556
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.449 0.551
E26.0 Primary hyperaldosteronism
0.000 0.449 0.551
E22 Hyperfunction of pituitary gland
0.000 0.452 0.548
E34.8 Other specified endocrine disorders
0.000 0.454 0.546
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.456 0.544
E04.0 Non-toxic diffuse goitre
0.000 0.457 0.543
E11.7 With multiple complications
0.000 0.459 0.541
E15 Nondiabetic hypoglycaemic coma
0.000 0.459 0.540
E29.9 Testicular dysfunction, unspecified
0.000 0.461 0.539
E29.8 Other testicular dysfunction
0.000 0.461 0.539
E29.0 Testicular hyperfunction
0.000 0.461 0.539
E13.9 Without complications
0.000 0.461 0.539
E78.6 Lipoprotein deficiency
0.000 0.462 0.538
E88 Other metabolic disorders
0.000 0.469 0.531
E26.9 Hyperaldosteronism, unspecified
0.000 0.471 0.529
E26.8 Other hyperaldosteronism
0.000 0.471 0.529
E26.1 Secondary hyperaldosteronism
0.000 0.471 0.529
L43.3 Subacute (active) lichen planus
0.000 0.473 0.527
L43.2 Lichenoid drug reaction
0.000 0.473 0.527
L43.1 Bullous lichen planus
0.000 0.473 0.527
L43.0 Hypertrophic lichen planus
0.000 0.473 0.527
E13.8 With unspecified complications
0.000 0.476 0.524
E13.7 With multiple complications
0.000 0.476 0.524
E13.6 With other specified complications
0.000 0.476 0.524
E13.5 With peripheral circulatory complications
0.000 0.476 0.524
E13.4 With neurological complications
0.000 0.476 0.524
E13.2 With renal complications
0.000 0.476 0.524
E13.1 With ketoacidosis
0.000 0.476 0.524
E13.0 With coma
0.000 0.476 0.524
L40.8 Other psoriasis
0.000 0.477 0.523
E13.3 With ophthalmic complications
0.000 0.477 0.523
E11.8 With unspecified complications
0.000 0.479 0.521
L42 Pityriasis rosea
0.000 0.481 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.486 0.513
E30.8 Other disorders of puberty
0.000 0.486 0.513
E30.1 Precocious puberty
0.000 0.486 0.513
E30.0 Delayed puberty
0.000 0.486 0.513
E31.9 Polyglandular dysfunction, unspecified
0.000 0.486 0.513
E31.8 Other polyglandular dysfunction
0.000 0.486 0.513
E31.1 Polyglandular hyperfunction
0.000 0.486 0.513
E31.0 Autoimmune polyglandular failure
0.000 0.486 0.513
E32.9 Disease of thymus, unspecified
0.000 0.486 0.513
E32.8 Other diseases of thymus
0.000 0.486 0.513
E32.1 Abscess of thymus
0.000 0.486 0.513
E32.0 Persistent hyperplasia of thymus
0.000 0.486 0.513
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.486 0.513
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.486 0.513
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.486 0.513
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.513
L58 Radiodermatitis
0.000 0.490 0.510
E11.6 With other specified complications
0.000 0.493 0.507
E78.1 Pure hyperglyceridaemia
0.000 0.497 0.502
E79 Disorders of purine and pyrimidine metabolism
0.000 0.505 0.494
L10-L14 Bullous disorders
0.000 0.511 0.489
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.513 0.487
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.514 0.486
E25.9 Adrenogenital disorder, unspecified
0.000 0.517 0.483
E25.8 Other adrenogenital disorders
0.000 0.517 0.483
E89.3 Postprocedural hypopituitarism
0.000 0.519 0.481
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.520 0.479
E34.5 Androgen resistance syndrome
0.000 0.521 0.479
E34.4 Constitutional tall stature
0.000 0.521 0.479
E34.3 Short stature, not elsewhere classified
0.000 0.521 0.479
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.521 0.479
E34.1 Other hypersecretion of intestinal hormones
0.000 0.521 0.479
E67 Other hyperalimentation
0.000 0.525 0.475
E68 Sequelae of hyperalimentation
0.000 0.525 0.475
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.531 0.469
E45 Retarded development following protein-energy malnutrition
0.000 0.531 0.469
E43 Unspecified severe protein-energy malnutrition
0.000 0.531 0.469
E42 Marasmic kwashiorkor
0.000 0.531 0.469
E41 Nutritional marasmus
0.000 0.531 0.469
E40 Kwashiorkor
0.000 0.531 0.469
E84 Cystic fibrosis
0.000 0.534 0.466
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.534 0.466
E77 Disorders of glycoprotein metabolism
0.000 0.544 0.456
E76 Disorders of glycosaminoglycan metabolism
0.000 0.544 0.456
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.544 0.456
E70 Disorders of aromatic amino-acid metabolism
0.000 0.544 0.456
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.544 0.456
L57.4 Cutis laxa senilis
0.000 0.550 0.450
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.550 0.450
E11.5 With peripheral circulatory complications
0.000 0.550 0.450
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.550 0.450
E21.0 Primary hyperparathyroidism
0.000 0.556 0.444
E88.3 Tumour lysis syndrome
0.000 0.559 0.441
L41.9 Parapsoriasis, unspecified
0.000 0.560 0.440
L41.8 Other parapsoriasis
0.000 0.560 0.440
L41.5 Retiform parapsoriasis
0.000 0.560 0.440
L41.4 Large plaque parapsoriasis
0.000 0.560 0.440
L41.3 Small plaque parapsoriasis
0.000 0.560 0.440
L41.2 Lymphomatoid papulosis
0.000 0.560 0.440
L41.1 Pityriasis lichenoides chronica
0.000 0.560 0.440
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.560 0.440
L44.9 Papulosquamous disorder, unspecified
0.000 0.560 0.440
L44.8 Other specified papulosquamous disorders
0.000 0.560 0.440
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.560 0.440
L44.3 Lichen ruber moniliformis
0.000 0.560 0.440
L44.2 Lichen striatus
0.000 0.560 0.440
L44.1 Lichen nitidus
0.000 0.560 0.440
L44.0 Pityriasis rubra pilaris
0.000 0.560 0.440
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.560 0.439
E20.1 Pseudohypoparathyroidism
0.000 0.562 0.438
E20.0 Idiopathic hypoparathyroidism
0.000 0.562 0.438
E07 Other disorders of thyroid
0.000 0.563 0.437
E88.8 Other specified metabolic disorders
0.000 0.563 0.437
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.564 0.436
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.565 0.435
E89.4 Postprocedural ovarian failure
0.000 0.567 0.433
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.567 0.433
E89.5 Postprocedural testicular hypofunction
0.000 0.567 0.433
E04.8 Other specified non-toxic goitre
0.000 0.567 0.433
E16.2 Hypoglycaemia, unspecified
0.000 0.568 0.432
L56.3 Solar urticaria
0.000 0.569 0.430
L56.2 Photocontact dermatitis [berloque dermatitis]
0.000 0.569 0.430
L56.1 Drug photoallergic response
0.000 0.569 0.430
L56.0 Drug phototoxic response
0.000 0.569 0.430
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.570 0.430
E34.9 Endocrine disorder, unspecified
0.000 0.571 0.429
E06.1 Subacute thyroiditis
0.000 0.575 0.424
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.582 0.418
E04.2 Non-toxic multinodular goitre
0.000 0.584 0.416
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.586 0.414
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.586 0.414
E16.4 Abnormal secretion of gastrin
0.000 0.586 0.414
E16.3 Increased secretion of glucagon
0.000 0.586 0.414
E20.9 Hypoparathyroidism, unspecified
0.000 0.590 0.409
C44.9 Malignant neoplasm of skin, unspecified
0.001 0.594 0.405
E46 Unspecified protein-energy malnutrition
0.000 0.595 0.405
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.595 0.405
E88.2 Lipomatosis, not elsewhere classified
0.000 0.596 0.404
E89.1 Postprocedural hypoinsulinaemia
0.000 0.596 0.404
E78.4 Other hyperlipidaemia
0.000 0.600 0.399
L55.9 Sunburn, unspecified
0.000 0.601 0.399
L55.8 Other sunburn
0.000 0.601 0.399
L55.2 Sunburn of third degree
0.000 0.601 0.399
L55.1 Sunburn of second degree
0.000 0.601 0.399
L55.0 Sunburn of first degree
0.000 0.601 0.399
E89.2 Postprocedural hypoparathyroidism
0.000 0.602 0.398
E16.1 Other hypoglycaemia
0.000 0.604 0.396
L59.9 Disorder of skin and subcutaneous tissue related to radiation, unspecified
0.000 0.604 0.395
L59.0 Erythema ab igne [dermatitis ab igne]
0.000 0.604 0.395
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.607 0.393
E22.8 Other hyperfunction of pituitary gland
0.000 0.607 0.393
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.607 0.393
E78.3 Hyperchylomicronaemia
0.000 0.609 0.391
L59.8 Other specified disorders of skin and subcutaneous tissue related to radiation
0.000 0.609 0.391
E22.1 Hyperprolactinaemia
0.000 0.610 0.390
E72 Other disorders of amino-acid metabolism
0.000 0.610 0.390
E11.1 With ketoacidosis
0.000 0.610 0.389
L56.4 Polymorphous light eruption
0.000 0.611 0.389
E74 Other disorders of carbohydrate metabolism
0.000 0.619 0.380
E34.0 Carcinoid syndrome
0.000 0.622 0.377
E04.9 Non-toxic goitre, unspecified
0.000 0.625 0.375
E20.8 Other hypoparathyroidism
0.000 0.628 0.372
E78.8 Other disorders of lipoprotein metabolism
0.000 0.628 0.372
E73 Lactose intolerance
0.000 0.629 0.371
E85 Amyloidosis
0.000 0.631 0.368
E88.9 Metabolic disorder, unspecified
0.000 0.632 0.368
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.633 0.367
L58.1 Chronic radiodermatitis
0.000 0.634 0.366
L58.0 Acute radiodermatitis
0.000 0.634 0.366
L12 Pemphigoid
0.000 0.635 0.364
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.645 0.355
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.645 0.355
E79.1 Lesch-Nyhan syndrome
0.000 0.645 0.355
L10 Pemphigus
0.000 0.649 0.351
L14 Bullous disorders in diseases classified elsewhere
0.000 0.649 0.351
L11 Other acantholytic disorders
0.000 0.653 0.347
E84.9 Cystic fibrosis, unspecified
0.000 0.655 0.345
E80.4 Gilbert's syndrome
0.000 0.658 0.342
E67.8 Other specified hyperalimentation
0.000 0.659 0.340
E67.3 Hypervitaminosis D
0.000 0.659 0.340
E67.2 Megavitamin-B6 syndrome
0.000 0.659 0.340
E67.1 Hypercarotenaemia
0.000 0.659 0.340
E67.0 Hypervitaminosis A
0.000 0.659 0.340
E44.1 Mild protein-energy malnutrition
0.000 0.664 0.336
E44.0 Moderate protein-energy malnutrition
0.000 0.664 0.336
E84.8 Cystic fibrosis with other manifestations
0.000 0.665 0.334
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.665 0.334
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.665 0.334
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.665 0.334
E50-E64 Other nutritional deficiencies
0.000 0.671 0.329
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.673 0.327
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.673 0.327
E70.3 Albinism
0.000 0.673 0.327
E70.2 Disorders of tyrosine metabolism
0.000 0.673 0.327
E70.1 Other hyperphenylalaninaemias
0.000 0.673 0.327
E70.0 Classical phenylketonuria
0.000 0.673 0.327
E71.3 Disorders of fatty-acid metabolism
0.000 0.673 0.327
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.673 0.327
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.673 0.327
E71.0 Maple-syrup-urine disease
0.000 0.673 0.327
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.673 0.327
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.673 0.327
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.673 0.327
E76.2 Other mucopolysaccharidoses
0.000 0.673 0.327
E76.1 Mucopolysaccharidosis, type II
0.000 0.673 0.327
E76.0 Mucopolysaccharidosis, type I
0.000 0.673 0.327
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.673 0.327
E77.8 Other disorders of glycoprotein metabolism
0.000 0.673 0.327
E77.1 Defects in glycoprotein degradation
0.000 0.673 0.327
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.673 0.327
E80.6 Other disorders of bilirubin metabolism
0.000 0.673 0.327
L13 Other bullous disorders
0.000 0.678 0.321
L58.9 Radiodermatitis, unspecified
0.000 0.680 0.320
C44.5 Skin of trunk
0.000 0.682 0.318
E07.1 Dyshormogenetic goitre
0.000 0.686 0.313
E07.0 Hypersecretion of calcitonin
0.000 0.686 0.313
E75.6 Lipid storage disorder, unspecified
0.000 0.687 0.312
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.687 0.312
E75.3 Sphingolipidosis, unspecified
0.000 0.687 0.312
E75.1 Other gangliosidosis
0.000 0.687 0.312
E75.0 GM2 gangliosidosis
0.000 0.687 0.312
L60-L75 Disorders of skin appendages
0.000 0.687 0.313
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.688 0.312
E80.5 Crigler-Najjar syndrome
0.000 0.688 0.312
E80.3 Defects of catalase and peroxydase
0.000 0.688 0.312
E80.0 Hereditary erythropoietic porphyria
0.000 0.688 0.312
E75.2 Other sphingolipidosis
0.000 0.694 0.306
E75.5 Other lipid storage disorders
0.000 0.700 0.299
M07 Psoriatic and enteropathic arthropathies
0.000 0.701 0.299
E11.9 Without complications
0.000 0.705 0.295
E80.1 Porphyria cutanea tarda
0.000 0.707 0.293
E07.8 Other specified disorders of thyroid
0.000 0.719 0.281
E03 Other hypothyroidism
0.000 0.720 0.280
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.720 0.280
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.720 0.280
E72.5 Disorders of glycine metabolism
0.000 0.720 0.280
E72.4 Disorders of ornithine metabolism
0.000 0.720 0.280
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.720 0.280
E72.2 Disorders of urea cycle metabolism
0.000 0.720 0.280
E85.4 Organ-limited amyloidosis
0.000 0.721 0.279
L12.9 Pemphigoid, unspecified
0.000 0.721 0.279
E22.0 Acromegaly and pituitary gigantism
0.000 0.723 0.277
E11.4 With neurological complications
0.000 0.724 0.276
E72.0 Disorders of amino-acid transport
0.000 0.725 0.275
L71 Rosacea
0.000 0.726 0.274
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.727 0.273
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.727 0.273
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.727 0.273
E74.2 Disorders of galactose metabolism
0.000 0.727 0.273
E74.1 Disorders of fructose metabolism
0.000 0.727 0.273
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.730 0.270
E74.0 Glycogen storage disease
0.000 0.730 0.270
E78.0 Pure hypercholesterolaemia
0.000 0.732 0.268
E83 Disorders of mineral metabolism
0.092 0.732 0.176
E73.8 Other lactose intolerance
0.000 0.734 0.266
E73.1 Secondary lactase deficiency
0.000 0.734 0.266
E73.0 Congenital lactase deficiency
0.000 0.734 0.266
E85.9 Amyloidosis, unspecified
0.000 0.735 0.265
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.736 0.264
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.736 0.264
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.736 0.264
E51 Thiamine deficiency
0.000 0.738 0.262
L12.8 Other pemphigoid
0.000 0.738 0.261
L12.3 Acquired epidermolysis bullosa
0.000 0.738 0.261
L12.2 Chronic bullous disease of childhood
0.000 0.738 0.261
L12.1 Cicatricial pemphigoid
0.000 0.740 0.260
L12.0 Bullous pemphigoid
0.000 0.741 0.258
L10.9 Pemphigus, unspecified
0.000 0.748 0.252
L10.8 Other pemphigus
0.000 0.748 0.252
L10.5 Drug-induced pemphigus
0.000 0.748 0.252
L10.4 Pemphigus erythematosus
0.000 0.748 0.252
L10.3 Brazilian pemphigus [fogo selvagem]
0.000 0.748 0.252
L10.2 Pemphigus foliaceus
0.000 0.748 0.252
L10.1 Pemphigus vegetans
0.000 0.748 0.252
L10.0 Pemphigus vulgaris
0.000 0.748 0.252
L11.0 Acquired keratosis follicularis
0.000 0.750 0.250
E80.2 Other porphyria
0.000 0.750 0.250
L68 Hypertrichosis
0.000 0.751 0.249
L11.9 Acantholytic disorder, unspecified
0.000 0.751 0.249
L11.8 Other specified acantholytic disorders
0.000 0.751 0.249
E56 Other vitamin deficiencies
0.000 0.753 0.247
L50-L54 Urticaria and erythema
0.000 0.755 0.245
L11.1 Transient acantholytic dermatosis [Grover]
0.000 0.757 0.243
L71.9 Rosacea, unspecified
0.000 0.762 0.238
L66 Cicatricial alopecia [scarring hair loss]
0.000 0.762 0.238
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.764 0.236
E50 Vitamin A deficiency
0.000 0.764 0.236
E60 Dietary zinc deficiency
0.000 0.764 0.236
E59 Dietary selenium deficiency
0.000 0.764 0.236
E52 Niacin deficiency [pellagra]
0.000 0.764 0.236
L13.9 Bullous disorder, unspecified
0.000 0.769 0.231
L13.8 Other specified bullous disorders
0.000 0.769 0.231
L13.1 Subcorneal pustular dermatitis
0.000 0.769 0.231
L63 Alopecia areata
0.000 0.772 0.228
E85.8 Other amyloidosis
0.000 0.776 0.224
L75 Apocrine sweat disorders
0.000 0.776 0.224
L74 Eccrine sweat disorders
0.000 0.776 0.224
L67 Hair colour and hair shaft abnormalities
0.000 0.776 0.224
L64 Androgenic alopecia
0.000 0.776 0.224
L62 Nail disorders in diseases classified elsewhere
0.000 0.776 0.224
E63 Other nutritional deficiencies
0.000 0.776 0.224
L60 Nail disorders
0.000 0.777 0.223
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.778 0.221
E55 Vitamin D deficiency
0.000 0.781 0.219
M07.5 Arthropathy in ulcerative colitis
0.000 0.785 0.214
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.785 0.214
M07.2 Psoriatic spondylitis
0.000 0.785 0.214
M07.1 Arthritis mutilans
0.000 0.785 0.214
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.785 0.214
E51.2 Wernicke's encephalopathy
0.000 0.786 0.214
L71.1 Rhinophyma
0.000 0.787 0.213
E54 Ascorbic acid deficiency
0.000 0.787 0.212
L60.9 Nail disorder, unspecified
0.000 0.790 0.209
L70 Acne
0.000 0.793 0.207
E85.3 Secondary systemic amyloidosis
0.000 0.793 0.206
E58 Dietary calcium deficiency
0.000 0.794 0.206
L68.0 Hirsutism
0.000 0.797 0.203
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.798 0.202
L51 Erythema multiforme
0.000 0.798 0.202
L13.0 Dermatitis herpetiformis
0.000 0.799 0.201
E03.5 Myxoedema coma
0.000 0.799 0.201
E03.4 Atrophy of thyroid (acquired)
0.000 0.799 0.201
E03.3 Postinfectious hypothyroidism
0.000 0.799 0.201
L65 Other nonscarring hair loss
0.000 0.801 0.199
M07.6 Other enteropathic arthropathies
0.000 0.801 0.198

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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