TreeWAS – Variant ID: rs2844520

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	1.000
L40.9 Psoriasis, unspecified	0.000	1.000
L40 Psoriasis	0.000	1.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.000	1.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	1.000
# Top node	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	1.000
L40-L45 Papulosquamous disorders	0.000	1.000
E03 Other hypothyroidism	0.000	1.000
E10-E14 Diabetes mellitus	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.001	0.999
C44 Other malignant neoplasms of skin	0.001	0.999
C44.3 Skin of other and unspecified parts of face	0.002	0.998
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.002	0.998
L40.5 Arthropathic psoriasis	0.004	0.996
Chapter IX Diseases of the circulatory system	0.005	0.995
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.006	0.994
C43-C44 Melanoma and other malignant neoplasms of skin	0.007	0.993
Chapter II Neoplasms	0.008	0.992
L57 Skin changes due to chronic exposure to nonionising radiation	0.010	0.990
M06.9 Rheumatoid arthritis, unspecified	0.010	0.990
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.011	0.989
L00-L08 Infections of the skin and subcutaneous tissue	0.012	0.988
D50-D53 Nutritional anaemias	0.014	0.986
D50 Iron deficiency anaemia	0.018	0.982
L57.0 Actinic keratosis	0.019	0.981
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.019	0.981
Chapter I Certain infectious and parasitic diseases	0.020	0.980
I20-I25 Ischaemic heart diseases	0.020	0.980
E10.9 Without complications	0.021	0.979
I21 Acute myocardial infarction	0.022	0.978
D50.9 Iron deficiency anaemia, unspecified	0.023	0.977
M06 Other rheumatoid arthritis	0.026	0.974
I60-I69 Cerebrovascular diseases	0.028	0.972
E65-E68 Obesity and other hyperalimentation	0.029	0.971
E10.3 With ophthalmic complications	0.031	0.969
C44.4 Skin of scalp and neck	0.032	0.968
L02 Cutaneous abscess, furuncle and carbuncle	0.033	0.967
M05-M14 Inflammatory polyarthropathies	0.036	0.964
C44.1 Skin of eyelid, including canthus	0.037	0.963
I21.9 Acute myocardial infarction, unspecified	0.037	0.963
E70-E90 Metabolic disorders	0.048	0.952
E66 Obesity	0.048	0.952
E66.8 Other obesity	0.051	0.949
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.054	0.946
I21.1 Acute transmural myocardial infarction of inferior wall	0.055	0.945
L08 Other local infections of skin and subcutaneous tissue	0.056	0.944
D60-D64 Aplastic and other anaemias	0.056	0.944
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk	0.056	0.944
B25-B34 Other viral diseases	0.058	0.942
B35-B49 Mycoses	0.062	0.937
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.068	0.932
I70-I79 Diseases of arteries, arterioles and capillaries	0.071	0.929
C64-C68 Malignant neoplasms of urinary tract	0.072	0.928
I60 Subarachnoid haemorrhage	0.077	0.923
I21.2 Acute transmural myocardial infarction of other sites	0.077	0.923
C44.7 Skin of lower limb, including hip	0.078	0.922
B37 Candidiasis	0.083	0.917
D64 Other anaemias	0.084	0.916
Chapter VIII Diseases of the ear and mastoid process	0.087	0.913
L08.9 Local infection of skin and subcutaneous tissue, unspecified	0.088	0.912
M07 Psoriatic and enteropathic arthropathies	0.089	0.911
C34 Malignant neoplasm of bronchus and lung	0.090	0.910
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.091	0.909
B34 Viral infection of unspecified site	0.093	0.907
E06 Thyroiditis	0.094	0.906
B37.8 Candidiasis of other sites	0.094	0.906
I73 Other peripheral vascular diseases	0.097	0.903
I69 Sequelae of cerebrovascular disease	0.101	0.899
E87 Other disorders of fluid, electrolyte and acid-base balance	0.102	0.898
D64.9 Anaemia, unspecified	0.103	0.897
E10.1 With ketoacidosis	0.109	0.891
E05 Thyrotoxicosis [hyperthyroidism]	0.112	0.888
I73.0 Raynaud's syndrome	0.116	0.884
B34.9 Viral infection, unspecified	0.118	0.882
I67 Other cerebrovascular diseases	0.121	0.879
I05-I09 Chronic rheumatic heart diseases	0.121	0.879
E50-E64 Other nutritional deficiencies	0.122	0.878
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.122	0.877
M07.3 Other psoriatic arthropathies	0.126	0.874
C34.9 Bronchus or lung, unspecified	0.129	0.871
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.130	0.870
D80-D89 Certain disorders involving the immune mechanism	0.137	0.863
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.138	0.862
E10.4 With neurological complications	0.144	0.856
E14 Unspecified diabetes mellitus	0.149	0.851
I77 Other disorders of arteries and arterioles	0.149	0.851
L02.4 Cutaneous abscess, furuncle and carbuncle of limb	0.152	0.848
I67.8 Other specified cerebrovascular diseases	0.156	0.844
E87.1 Hypo-osmolality and hyponatraemia	0.157	0.843
H65-H75 Diseases of middle ear and mastoid	0.157	0.843
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.167	0.833
E06.3 Autoimmune thyroiditis	0.167	0.833
E89.0 Postprocedural hypothyroidism	0.168	0.832
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.171	0.829
C67 Malignant neoplasm of bladder	0.175	0.825
H72 Perforation of tympanic membrane	0.176	0.824
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.178	0.822
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.186	0.814
M07.39 Other psoriatic arthropathies (Site unspecified)	0.187	0.813
H72.9 Perforation of tympanic membrane, unspecified	0.191	0.809
I77.1 Stricture of artery	0.192	0.808
E10.5 With peripheral circulatory complications	0.193	0.807
E53 Deficiency of other B group vitamins	0.193	0.807
I60.2 Subarachnoid haemorrhage from anterior communicating artery	0.193	0.807
C44.2 Skin of ear and external auricular canal	0.194	0.806
E86 Volume depletion	0.194	0.806
M06.0 Seronegative rheumatoid arthritis	0.197	0.803
E11 Non-insulin-dependent diabetes mellitus	0.198	0.802
M05 Seropositive rheumatoid arthritis	0.202	0.798
D86 Sarcoidosis	0.202	0.798
I63 Cerebral infarction	0.206	0.794
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum	0.206	0.794
B35 Dermatophytosis	0.209	0.791
I69.3 Sequelae of cerebral infarction	0.211	0.789
I05 Rheumatic mitral valve diseases	0.212	0.788
B99-B99 Other infectious diseases	0.212	0.788
M45-M49 Spondylopathies	0.218	0.782
C44.0 Skin of lip	0.223	0.777
H80-H83 Diseases of inner ear	0.223	0.777
L40.0 Psoriasis vulgaris	0.224	0.776
E05.0 Thyrotoxicosis with diffuse goitre	0.226	0.774
E10.2 With renal complications	0.226	0.774
B37.0 Candidal stomatitis	0.227	0.773
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.228	0.772
D55-D59 Haemolytic anaemias	0.228	0.772
C66 Malignant neoplasm of ureter	0.230	0.770
D61 Other aplastic anaemias	0.231	0.769
E87.6 Hypokalaemia	0.233	0.767
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.233	0.767
B20-B24 Human immunodeficiency virus [HIV] disease	0.234	0.766
M07.30 Other psoriatic arthropathies (Multiple sites)	0.234	0.766
M45 Ankylosing spondylitis	0.242	0.758
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.243	0.757
E53.8 Deficiency of other specified B group vitamins	0.244	0.756
I60.9 Subarachnoid haemorrhage, unspecified	0.244	0.756
E87.2 Acidosis	0.246	0.754
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs	0.246	0.754
E05.9 Thyrotoxicosis, unspecified	0.246	0.754
H65 Nonsuppurative otitis media	0.247	0.753
L20-L30 Dermatitis and eczema	0.248	0.752
E14.9 Without complications	0.249	0.751
L02.3 Cutaneous abscess, furuncle and carbuncle of buttock	0.249	0.751
A00-A09 Intestinal infectious diseases	0.252	0.748
C34.3 Lower lobe, bronchus or lung	0.254	0.746
E40-E46 Malnutrition	0.255	0.745
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.258	0.742
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.258	0.742
M45.X9 Ankylosing spondylitis (Site unspecified)	0.259	0.741
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.260	0.740
L05 Pilonidal cyst	0.262	0.738
Chapter V Mental and behavioural disorders	0.263	0.737
C34.1 Upper lobe, bronchus or lung	0.266	0.734
B25 Cytomegaloviral disease	0.266	0.734
Chapter XXII Codes for special purposes	0.267	0.733
C65 Malignant neoplasm of renal pelvis	0.268	0.732
C34.2 Middle lobe, bronchus or lung	0.269	0.731
M95.0 Acquired deformity of nose	0.269	0.731
I08 Multiple valve diseases	0.270	0.730
A50-A64 Infections with a predominantly sexual mode of transmission	0.271	0.729
I70 Atherosclerosis	0.271	0.729
C67.2 Lateral wall of bladder	0.273	0.727
E73 Lactose intolerance	0.274	0.726
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.274	0.726
D86.9 Sarcoidosis, unspecified	0.283	0.717
D50.8 Other iron deficiency anaemias	0.283	0.717
L40.8 Other psoriasis	0.283	0.717
L40.4 Guttate psoriasis	0.283	0.717
L40.3 Pustulosis palmaris et plantaris	0.283	0.717
L40.2 Acrodermatitis continua	0.283	0.717
L40.1 Generalised pustular psoriasis	0.283	0.717
Chapter XVI Certain conditions originating in the perinatal period	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.283	0.717
E02 Subclinical iodine-deficiency hypothyroidism	0.283	0.717
L44 Other papulosquamous disorders	0.283	0.717
L41 Parapsoriasis	0.283	0.717
L45 Papulosquamous disorders in diseases classified elsewhere	0.283	0.717
I60.8 Other subarachnoid haemorrhage	0.283	0.717
E03.5 Myxoedema coma	0.283	0.717
E03.4 Atrophy of thyroid (acquired)	0.283	0.717
E03.3 Postinfectious hypothyroidism	0.283	0.717
E03.1 Congenital hypothyroidism without goitre	0.283	0.717
E03.0 Congenital hypothyroidism with diffuse goitre	0.283	0.717
I63.9 Cerebral infarction, unspecified	0.283	0.717
E12 Malnutrition-related diabetes mellitus	0.283	0.717
E10.8 With unspecified complications	0.283	0.716
E10.7 With multiple complications	0.283	0.716
E10.0 With coma	0.283	0.716
L56 Other acute skin changes due to ultraviolet radiation	0.284	0.716
C44.8 Overlapping lesion of skin	0.284	0.716
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.286	0.714
H72.0 Central perforation of tympanic membrane	0.286	0.713
I00-I02 Acute rheumatic fever	0.287	0.713
L59 Other disorders of skin and subcutaneous tissue related to radiation	0.287	0.713
L58 Radiodermatitis	0.287	0.713
L55 Sunburn	0.287	0.713
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.287	0.713
C40-C41 Malignant neoplasms of bone and articular cartilage	0.289	0.711
I67.2 Cerebral atherosclerosis	0.290	0.710
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified	0.290	0.710
L57.5 Actinic granuloma	0.290	0.710
L57.3 Poikiloderma of Civatte	0.290	0.710
L57.2 Cutis rhomboidalis nuchae	0.290	0.710
L57.1 Actinic reticuloid	0.290	0.710
M06.98 Rheumatoid arthritis, unspecified (Other)	0.290	0.709
L04 Acute lymphadenitis	0.292	0.708
L01 Impetigo	0.292	0.708
L00 Staphylococcal scalded skin syndrome	0.292	0.708
I22 Subsequent myocardial infarction	0.293	0.707
E11.3 With ophthalmic complications	0.293	0.707
M00-M03 Infectious arthropathies	0.294	0.706
E80 Disorders of porphyrin and bilirubin metabolism	0.294	0.706
D86.0 Sarcoidosis of lung	0.295	0.705
D50.1 Sideropenic dysphagia	0.296	0.704
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.297	0.703
B85-B89 Pediculosis, acariasis and other infestations	0.297	0.702
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.297	0.702
A75-A79 Rickettsioses	0.297	0.702
A70-A74 Other diseases caused by chlamydiae	0.297	0.702
A65-A69 Other spirochaetal diseases	0.297	0.702
A20-A28 Certain zoonotic bacterial diseases	0.297	0.702
A15-A19 Tuberculosis	0.297	0.702
I05.9 Mitral valve disease, unspecified	0.298	0.702
I21.X Presumed acute myicardial infaction (unconfirmed)	0.299	0.701
I21.3 Acute transmural myocardial infarction of unspecified site	0.299	0.701
H60-H62 Diseases of external ear	0.301	0.699
M06.8 Other specified rheumatoid arthritis	0.301	0.698
M06.2 Rheumatoid bursitis	0.301	0.698
M06.1 Adult-onset Still's disease	0.301	0.698
I62 Other nontraumatic intracranial haemorrhage	0.302	0.698
L10-L14 Bullous disorders	0.303	0.697
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.303	0.697
I68 Cerebrovascular disorders in diseases classified elsewhere	0.303	0.697
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.303	0.697
I95-I99 Other and unspecified disorders of the circulatory system	0.303	0.696
E67 Other hyperalimentation	0.304	0.696
E68 Sequelae of hyperalimentation	0.304	0.696
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.305	0.695
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites	0.307	0.693
E88 Other metabolic disorders	0.307	0.693
M12 Other specific arthropathies	0.309	0.691
M09 Juvenile arthritis in diseases classified elsewhere	0.309	0.691
M08 Juvenile arthritis	0.309	0.691
L08.8 Other specified local infections of skin and subcutaneous tissue	0.310	0.690
B65-B83 Helminthiases	0.311	0.689
B50-B64 Protozoal diseases	0.312	0.688
M60-M63 Disorders of muscles	0.312	0.687
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.313	0.687
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.314	0.686
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.314	0.686
E74 Other disorders of carbohydrate metabolism	0.317	0.683
R41 Other symptoms and signs involving cognitive functions and awareness	0.317	0.683
E84 Cystic fibrosis	0.317	0.683
E79 Disorders of purine and pyrimidine metabolism	0.317	0.683
E77 Disorders of glycoprotein metabolism	0.317	0.683
E76 Disorders of glycosaminoglycan metabolism	0.317	0.683
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.317	0.683
E72 Other disorders of amino-acid metabolism	0.317	0.683
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.317	0.683
E70 Disorders of aromatic amino-acid metabolism	0.317	0.683
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.317	0.683
E66.1 Drug-induced obesity	0.317	0.682
E66.0 Obesity due to excess calories	0.317	0.682
I77.6 Arteritis, unspecified	0.318	0.682
E13 Other specified diabetes mellitus	0.320	0.680
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.320	0.680
M05.9 Seropositive rheumatoid arthritis, unspecified	0.320	0.680
B90-B94 Sequelae of infectious and parasitic diseases	0.321	0.679
A30-A49 Other bacterial diseases	0.322	0.678
L08.1 Erythrasma	0.323	0.677
L08.0 Pyoderma	0.323	0.677
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.323	0.677
E10.6 With other specified complications	0.324	0.676
M14 Arthropathies in other diseases classified elsewhere	0.325	0.675
B33 Other viral diseases, not elsewhere classified	0.325	0.675
B30 Viral conjunctivitis	0.325	0.675
B27 Infectious mononucleosis	0.325	0.675
B26 Mumps	0.325	0.675
R47-R49 Symptoms and signs involving speech and voice	0.327	0.673
C78.0 Secondary malignant neoplasm of lung	0.327	0.673
B48 Other mycoses, not elsewhere classified	0.328	0.672
B47 Mycetoma	0.328	0.672
B46 Zygomycosis	0.328	0.672
B45 Cryptococcosis	0.328	0.672
B43 Chromomycosis and phaeomycotic abscess	0.328	0.672
B42 Sporotrichosis	0.328	0.672
B41 Paracoccidioidomycosis	0.328	0.672
B40 Blastomycosis	0.328	0.672
B39 Histoplasmosis	0.328	0.672
B38 Coccidioidomycosis	0.328	0.672
B36 Other superficial mycoses	0.328	0.672
E06.9 Thyroiditis, unspecified	0.328	0.672
B15-B19 Viral hepatitis	0.328	0.672
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.329	0.671
E65 Localised adiposity	0.329	0.670
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs	0.332	0.668
C31 Malignant neoplasm of accessory sinuses	0.332	0.668
C30 Malignant neoplasm of nasal cavity and middle ear	0.332	0.668
C37 Malignant neoplasm of thymus	0.332	0.668
C33 Malignant neoplasm of trachea	0.332	0.668
C64 Malignant neoplasm of kidney, except renal pelvis	0.332	0.668
C68 Malignant neoplasm of other and unspecified urinary organs	0.335	0.665
D52 Folate deficiency anaemia	0.335	0.664
I23 Certain current complications following acute myocardial infarction	0.337	0.663
R26 Abnormalities of gait and mobility	0.338	0.662
L02.9 Cutaneous abscess, furuncle and carbuncle, unspecified	0.338	0.662
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.338	0.662
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.338	0.662
I60.5 Subarachnoid haemorrhage from vertebral artery	0.338	0.662
I60.4 Subarachnoid haemorrhage from basilar artery	0.338	0.662
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.338	0.662
C51-C58 Malignant neoplasms of female genital organs	0.338	0.661
I77.8 Other specified disorders of arteries and arterioles	0.339	0.661
R41.0 Disorientation, unspecified	0.340	0.660
D70-D77 Other diseases of blood and blood-forming organs	0.340	0.660
B37.7 Candidal septicaemia	0.342	0.658
B37.6 Candidal endocarditis	0.342	0.658
B37.5 Candidal meningitis	0.342	0.658
B37.2 Candidiasis of skin and nail	0.342	0.658
E03.8 Other specified hypothyroidism	0.342	0.658
D64.4 Congenital dyserythropoietic anaemia	0.343	0.657
D64.3 Other sideroblastic anaemias	0.343	0.657
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.343	0.657
D64.1 Secondary sideroblastic anaemia due to disease	0.343	0.657
D64.0 Hereditary sideroblastic anaemia	0.343	0.657
H65.9 Nonsuppurative otitis media, unspecified	0.343	0.657
R41.3 Other amnesia	0.344	0.656
D64.8 Other specified anaemias	0.345	0.655
C67.9 Bladder, unspecified	0.345	0.655
M07.6 Other enteropathic arthropathies	0.346	0.653
M07.5 Arthropathy in ulcerative colitis	0.346	0.653
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.346	0.653
M07.2 Psoriatic spondylitis	0.346	0.653
M07.1 Arthritis mutilans	0.346	0.653
M07.0 Distal interphalangeal psoriatic arthropathy	0.346	0.653
C34.8 Overlapping lesion of bronchus and lung	0.347	0.653
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.348	0.652
H80 Otosclerosis	0.349	0.651
L57.4 Cutis laxa senilis	0.349	0.651
B35.1 Tinea unguium	0.350	0.650
B99 Other and unspecified infectious diseases	0.350	0.650
B34.8 Other viral infections of unspecified site	0.350	0.650
B34.4 Papovirus infection, unspecified	0.350	0.650
B34.3 Parvovirus infection, unspecified	0.350	0.650
B34.2 Coronavirus infection, unspecified	0.350	0.650
B34.1 Enterovirus infection, unspecified	0.350	0.650
B34.0 Adenovirus infection, unspecified	0.350	0.650
E06.5 Other chronic thyroiditis	0.350	0.650
E06.4 Drug-induced thyroiditis	0.350	0.650
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.350	0.650
E06.1 Subacute thyroiditis	0.350	0.650
E06.0 Acute thyroiditis	0.350	0.650
C79 Secondary malignant neoplasm of other sites	0.352	0.648
I73.9 Peripheral vascular disease, unspecified	0.353	0.647
I73.1 Thromboangiitis obliterans [Buerger]	0.353	0.647
E11.5 With peripheral circulatory complications	0.354	0.646
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.354	0.646
I73.8 Other specified peripheral vascular diseases	0.354	0.646
D61.9 Aplastic anaemia, unspecified	0.356	0.644
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.356	0.644
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.356	0.644
E87.4 Mixed disorder of acid-base balance	0.356	0.644
M11 Other crystal arthropathies	0.357	0.643
I61 Intracerebral haemorrhage	0.358	0.642
E55 Vitamin D deficiency	0.359	0.641
A80-A89 Viral infections of the central nervous system	0.363	0.637
E05.5 Thyroid crisis or storm	0.363	0.637
E05.4 Thyrotoxicosis factitia	0.363	0.637
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.363	0.637
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.363	0.637
C67.1 Dome of bladder	0.363	0.637
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.365	0.635
I24 Other acute ischaemic heart diseases	0.365	0.635
L43 Lichen planus	0.367	0.633
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.367	0.633
C44.6 Skin of upper limb, including shoulder	0.368	0.632
C38 Malignant neoplasm of heart, mediastinum and pleura	0.368	0.632
R47 Speech disturbances, not elsewhere classified	0.370	0.630
I67.7 Cerebral arteritis, not elsewhere classified	0.370	0.630
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.370	0.630
I67.5 Moyamoya disease	0.370	0.630
I67.4 Hypertensive encephalopathy	0.370	0.630
I67.3 Progressive vascular leukoencephalopathy	0.370	0.630
I09 Other rheumatic heart diseases	0.370	0.630
E64 Sequelae of malnutrition and other nutritional deficiencies	0.370	0.630
E63 Other nutritional deficiencies	0.370	0.630
E56 Other vitamin deficiencies	0.370	0.630
E51 Thiamine deficiency	0.370	0.630
E50 Vitamin A deficiency	0.370	0.630
E60 Dietary zinc deficiency	0.370	0.630
E59 Dietary selenium deficiency	0.370	0.630
E58 Dietary calcium deficiency	0.370	0.630
E54 Ascorbic acid deficiency	0.370	0.630
E52 Niacin deficiency [pellagra]	0.370	0.630
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.371	0.629
E89.8 Other postprocedural endocrine and metabolic disorders	0.371	0.629
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.371	0.629
E89.5 Postprocedural testicular hypofunction	0.371	0.629
E89.4 Postprocedural ovarian failure	0.371	0.629
E89.1 Postprocedural hypoinsulinaemia	0.371	0.629
M06.3 Rheumatoid nodule	0.372	0.627
M07.38 Other psoriatic arthropathies (Other)	0.373	0.627
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.373	0.627
M07.36 Other psoriatic arthropathies (Lower leg)	0.373	0.627
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.373	0.627
M07.34 Other psoriatic arthropathies (Hand)	0.373	0.627
M07.33 Other psoriatic arthropathies (Forearm)	0.373	0.627
M07.32 Other psoriatic arthropathies (Upper arm)	0.373	0.627
M07.31 Other psoriatic arthropathies (Shoulder region)	0.373	0.627
L02.1 Cutaneous abscess, furuncle and carbuncle of neck	0.374	0.626
L29 Pruritus	0.374	0.626
B37.1 Pulmonary candidiasis	0.375	0.625
D53 Other nutritional anaemias	0.375	0.625
E66.2 Extreme obesity with alveolar hypoventilation	0.375	0.625
B35.3 Tinea pedis	0.376	0.624
A08 Viral and other specified intestinal infections	0.377	0.623
H70 Mastoiditis and related conditions	0.377	0.623
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.378	0.622
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.378	0.622
R26.8 Other and unspecified abnormalities of gait and mobility	0.378	0.622
D84 Other immunodeficiencies	0.381	0.619
D83 Common variable immunodeficiency	0.381	0.619
D82 Immunodeficiency associated with other major defects	0.381	0.619
D81 Combined immunodeficiencies	0.381	0.619
I70.2 Atherosclerosis of arteries of the extremities	0.381	0.619
I05.0 Mitral stenosis	0.382	0.618
C76 Malignant neoplasm of other and ill-defined sites	0.382	0.618
D59 Acquired haemolytic anaemia	0.382	0.617
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.383	0.617
I08.0 Disorders of both mitral and aortic valves	0.383	0.617
A02 Other Salmonella infections	0.384	0.616
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.384	0.616
L50-L54 Urticaria and erythema	0.384	0.616
E87.7 Fluid overload	0.385	0.615
I67.0 Dissection of cerebral arteries, nonruptured	0.385	0.615
C67.4 Posterior wall of bladder	0.386	0.614
M46 Other inflammatory spondylopathies	0.386	0.614
B24 Unspecified human immunodeficiency virus [HIV] disease	0.387	0.613
D51 Vitamin B12 deficiency anaemia	0.388	0.612
L05.0 Pilonidal cyst with abscess	0.389	0.611
E89.3 Postprocedural hypopituitarism	0.389	0.610
E14.8 With unspecified complications	0.389	0.610
E14.7 With multiple complications	0.389	0.610
E14.6 With other specified complications	0.389	0.610
E14.5 With peripheral circulatory complications	0.389	0.610
E14.4 With neurological complications	0.389	0.610
E14.2 Withrenal complications	0.389	0.610
E14.1 With ketoacidosis	0.389	0.610
E14.0 With coma	0.389	0.610
I77.5 Necrosis of artery	0.390	0.610
I77.4 Coeliac artery compression syndrome	0.390	0.610
I77.3 Arterial fibromuscular dysplasia	0.390	0.610
I77.2 Rupture of artery	0.390	0.610
I95 Hypotension	0.390	0.610
D62 Acute posthaemorrhagic anaemia	0.391	0.609
E89.2 Postprocedural hypoparathyroidism	0.391	0.609
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.393	0.607
R47.0 Dysphasia and aphasia	0.394	0.606
M06.4 Inflammatory polyarthropathy	0.394	0.605
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.396	0.604
H68 Eustachian salpingitis and obstruction	0.396	0.604
H67 Otitis media in diseases classified elsewhere	0.396	0.604
E87.3 Alkalosis	0.396	0.604
E20-E35 Disorders of other endocrine glands	0.397	0.603
B37.4 Candidiasis of other urogenital sites	0.399	0.601
H83 Other diseases of inner ear	0.399	0.601
I69.0 Sequelae of subarachnoid haemorrhage	0.400	0.600
C67.5 Bladder neck	0.402	0.598
B37.3 Candidiasis of vulva and vagina	0.402	0.598
H65.4 Other chronic nonsuppurative otitis media	0.403	0.597
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.403	0.597
E11.1 With ketoacidosis	0.403	0.597
L02.0 Cutaneous abscess, furuncle and carbuncle of face	0.404	0.595
E14.3 With ophthalmic complications	0.405	0.595
M99 Biomechanical lesions, not elsewhere classified	0.406	0.594
C67.7 Urachus	0.408	0.592
C67.0 Trigone of bladder	0.408	0.592
D80 Immunodeficiency with predominantly antibody defects	0.409	0.591
L42 Pityriasis rosea	0.409	0.591
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.409	0.591
H72.1 Attic perforation of tympanic membrane	0.409	0.591
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs	0.411	0.589
I95.9 Hypotension, unspecified	0.413	0.587
H73 Other disorders of tympanic membrane	0.414	0.586
B25.9 Cytomegaloviral disease, unspecified	0.415	0.584
L29.0 Pruritus ani	0.416	0.584
I71 Aortic aneurysm and dissection	0.417	0.583
I07 Rheumatic tricuspid valve diseases	0.417	0.583
E11.9 Without complications	0.418	0.582
I69.1 Sequelae of intracerebral haemorrhage	0.419	0.581
C92 Myeloid leukaemia	0.419	0.581
C79.5 Secondary malignant neoplasm of bone and bone marrow	0.419	0.581
B37.9 Candidiasis, unspecified	0.421	0.579
E53.9 Vitamin B deficiency, unspecified	0.421	0.579
E53.1 Pyridoxine deficiency	0.421	0.579
E53.0 Riboflavin deficiency	0.421	0.579
C44.9 Malignant neoplasm of skin, unspecified	0.421	0.578
C34.0 Main bronchus	0.422	0.578
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.424	0.576

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations