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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2844635
log Bayes Factor = 208.882
Chromosome 6   position 31,075,481  (GRCh37) Explore rs2844635 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
M35.0 Sicca syndrome [Sjogren]
0.999 0.001 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.991 0.009 0.000
E10.2 With renal complications
0.987 0.013 0.000
E16 Other disorders of pancreatic internal secretion
0.985 0.015 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.980 0.020 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.977 0.023 0.000
E07 Other disorders of thyroid
0.977 0.023 0.000
E16.2 Hypoglycaemia, unspecified
0.976 0.024 0.000
E10.1 With ketoacidosis
0.969 0.031 0.000
C85.1 B-cell lymphoma, unspecified
0.963 0.037 0.000
K90 Intestinal malabsorption
0.960 0.040 0.000
E07.9 Disorder of thyroid, unspecified
0.958 0.042 0.000
E06 Thyroiditis
0.956 0.044 0.000
E14 Unspecified diabetes mellitus
0.944 0.056 0.000
L40.9 Psoriasis, unspecified
0.000 0.064 0.936
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.932 0.068 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.915 0.085 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.915 0.085 0.000
E06.3 Autoimmune thyroiditis
0.911 0.089 0.000
C81 Hodgkin's disease
0.910 0.090 0.000
C83.3 Large cell (diffuse)
0.906 0.094 0.000
E14.3 With ophthalmic complications
0.902 0.098 0.000
K90.9 Intestinal malabsorption, unspecified
0.893 0.107 0.000
C81.9 Hodgkin's disease, unspecified
0.874 0.126 0.000
E10.4 With neurological complications
0.843 0.157 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.831 0.169 0.000
E10.7 With multiple complications
0.803 0.197 0.000
C88 Malignant immunoproliferative diseases
0.795 0.205 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.782 0.218 0.000
E14.2 Withrenal complications
0.773 0.227 0.000
E14.8 With unspecified complications
0.766 0.234 0.000
E50-E64 Other nutritional deficiencies
0.766 0.234 0.000
E05.8 Other thyrotoxicosis
0.766 0.234 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.763 0.237 0.000
E20-E35 Disorders of other endocrine glands
0.761 0.239 0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.754 0.246 0.000
C81.1 Nodular sclerosis
0.748 0.252 0.000
E06.9 Thyroiditis, unspecified
0.746 0.254 0.000
K90.8 Other intestinal malabsorption
0.745 0.255 0.000
E16.1 Other hypoglycaemia
0.740 0.260 0.000
E07.8 Other specified disorders of thyroid
0.735 0.265 0.000
E03.8 Other specified hypothyroidism
0.732 0.268 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.725 0.274 0.000
C83.7 Burkitt's tumour
0.720 0.280 0.000
E89.0 Postprocedural hypothyroidism
0.720 0.280 0.000
C83.1 Small cleaved cell (diffuse)
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E10.0 With coma
0.717 0.283 0.000
E10.8 With unspecified complications
0.716 0.284 0.000
E14.1 With ketoacidosis
0.711 0.289 0.000
E15 Nondiabetic hypoglycaemic coma
0.711 0.289 0.000
E06.5 Other chronic thyroiditis
0.710 0.289 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.706 0.294 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.706 0.294 0.000
E16.4 Abnormal secretion of gastrin
0.706 0.294 0.000
E16.3 Increased secretion of glucagon
0.706 0.294 0.000
C81.2 Mixed cellularity
0.706 0.294 0.000
E14.4 With neurological complications
0.705 0.295 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.704 0.296 0.000
E70-E90 Metabolic disorders
0.702 0.298 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.701 0.299 0.000
C85.0 Lymphosarcoma
0.701 0.299 0.000
E07.1 Dyshormogenetic goitre
0.700 0.299 0.000
E07.0 Hypersecretion of calcitonin
0.700 0.299 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.695 0.305 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.695 0.305 0.000
E14.5 With peripheral circulatory complications
0.689 0.311 0.000
K90.3 Pancreatic steatorrhoea
0.688 0.312 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.688 0.312 0.000
K90.1 Tropical sprue
0.688 0.312 0.000
E06.1 Subacute thyroiditis
0.686 0.314 0.000
E06.4 Drug-induced thyroiditis
0.685 0.314 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.685 0.314 0.000
E06.0 Acute thyroiditis
0.685 0.314 0.000
C81.0 Lymphocytic predominance
0.685 0.315 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.683 0.317 0.000
E13 Other specified diabetes mellitus
0.679 0.321 0.000
E14.7 With multiple complications
0.677 0.323 0.000
E14.0 With coma
0.677 0.323 0.000
E10.5 With peripheral circulatory complications
0.669 0.331 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.668 0.332 0.000
C94 Other leukaemias of specified cell type
0.668 0.332 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.658 0.342 0.000
E03.1 Congenital hypothyroidism without goitre
0.657 0.342 0.000
C83.6 Undifferentiated (diffuse)
0.656 0.344 0.000
C83.5 Lymphoblastic (diffuse)
0.656 0.344 0.000
C83.4 Immunoblastic (diffuse)
0.656 0.344 0.000
C83.2 Mixed small and large cell (diffuse)
0.656 0.344 0.000
E51 Thiamine deficiency
0.655 0.345 0.000
C81.7 Other Hodgkin's disease
0.652 0.347 0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.652 0.347 0.000
C81.3 Lymphocytic depletion
0.652 0.347 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.652 0.348 0.000
C93 Monocytic leukaemia
0.650 0.349 0.000
E24 Cushing's syndrome
0.650 0.350 0.000
E23 Hypofunction and other disorders of pituitary gland
0.642 0.358 0.000
C86 Other specified types of T/NK-cell lymphoma
0.642 0.358 0.000
E14.6 With other specified complications
0.640 0.360 0.000
E10.6 With other specified complications
0.636 0.364 0.000
C88.0 Waldenstrom's macroglobulinaemia
0.633 0.367 0.000
E40-E46 Malnutrition
0.618 0.381 0.000
C61 Malignant neoplasm of prostate
0.000 0.384 0.616
M35 Other systemic involvement of connective tissue
0.615 0.385 0.000
C95 Leukaemia of unspecified cell type
0.605 0.395 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.602 0.398 0.000
E27 Other disorders of adrenal gland
0.591 0.409 0.000
E73 Lactose intolerance
0.590 0.409 0.000
E58 Dietary calcium deficiency
0.582 0.418 0.000
E21.3 Hyperparathyroidism, unspecified
0.578 0.422 0.000
E23.6 Other disorders of pituitary gland
0.576 0.424 0.000
E51.2 Wernicke's encephalopathy
0.575 0.425 0.000
C88.9 Malignant immunoproliferative disease, unspecified
0.570 0.430 0.000
C88.7 Other malignant immunoproliferative diseases
0.570 0.430 0.000
C88.3 Immunoproliferative small intestinal disease
0.570 0.430 0.000
C88.2 Gamma heavy chain disease
0.570 0.430 0.000
C88.1 Alpha heavy chain disease
0.570 0.430 0.000
E61 Deficiency of other nutrient elements
0.567 0.433 0.000
E31 Polyglandular dysfunction
0.562 0.438 0.000
E27.1 Primary adrenocortical insufficiency
0.561 0.439 0.000
E24.2 Drug-induced Cushing's syndrome
0.560 0.440 0.000
E89.4 Postprocedural ovarian failure
0.552 0.448 0.000
M35.7 Hypermobility syndrome
0.552 0.448 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.549 0.451 0.000
E63 Other nutritional deficiencies
0.549 0.451 0.000
E50 Vitamin A deficiency
0.549 0.451 0.000
E60 Dietary zinc deficiency
0.549 0.451 0.000
E59 Dietary selenium deficiency
0.549 0.451 0.000
E54 Ascorbic acid deficiency
0.549 0.451 0.000
E52 Niacin deficiency [pellagra]
0.549 0.451 0.000
E23.7 Disorder of pituitary gland, unspecified
0.549 0.451 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.546 0.454 0.000
E32 Diseases of thymus
0.546 0.454 0.000
E30 Disorders of puberty, not elsewhere classified
0.546 0.454 0.000
C91 Lymphoid leukaemia
0.541 0.459 0.000
E55 Vitamin D deficiency
0.536 0.464 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.533 0.467 0.000
E74 Other disorders of carbohydrate metabolism
0.530 0.470 0.000
E84 Cystic fibrosis
0.529 0.471 0.000
E88 Other metabolic disorders
0.526 0.474 0.000
E24.0 Pituitary-dependent Cushing's disease
0.524 0.476 0.000
E11 Non-insulin-dependent diabetes mellitus
0.521 0.479 0.000
E13.3 With ophthalmic complications
0.519 0.481 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.514 0.486 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.514 0.486 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.514 0.486 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.514 0.486 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.514 0.486 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.514 0.486 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.514 0.486 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.514 0.486 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
E72 Other disorders of amino-acid metabolism
0.514 0.486 0.000
E73.9 Lactose intolerance, unspecified
0.511 0.489 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.510 0.490 0.000
C84.8 Cutaneous T-cell lymphoma, unspecified
0.508 0.492 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.505 0.495 0.000
E89.5 Postprocedural testicular hypofunction
0.505 0.495 0.000
E89.1 Postprocedural hypoinsulinaemia
0.505 0.495 0.000
E77 Disorders of glycoprotein metabolism
0.503 0.497 0.000
E76 Disorders of glycosaminoglycan metabolism
0.503 0.497 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.503 0.497 0.000
E70 Disorders of aromatic amino-acid metabolism
0.503 0.497 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.503 0.497 0.000
E56 Other vitamin deficiencies
0.502 0.498 0.000
E20 Hypoparathyroidism
0.496 0.504 0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.493 0.507 0.000
E21.4 Other specified disorders of parathyroid gland
0.490 0.510 0.000
E13.8 With unspecified complications
0.487 0.513 0.000
E13.7 With multiple complications
0.487 0.513 0.000
E13.6 With other specified complications
0.487 0.513 0.000
E13.5 With peripheral circulatory complications
0.487 0.513 0.000
E13.4 With neurological complications
0.487 0.513 0.000
E13.2 With renal complications
0.487 0.513 0.000
E13.1 With ketoacidosis
0.487 0.513 0.000
E13.0 With coma
0.487 0.513 0.000
E22 Hyperfunction of pituitary gland
0.487 0.513 0.000
E28 Ovarian dysfunction
0.486 0.514 0.000
L40 Psoriasis
0.000 0.515 0.485
E26 Hyperaldosteronism
0.485 0.515 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.482 0.518 0.000
E25 Adrenogenital disorders
0.481 0.518 0.000
E21.2 Other hyperparathyroidism
0.481 0.518 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.480 0.520 0.000
C94.7 Other specified leukaemias
0.479 0.521 0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.479 0.521 0.000
C94.5 Acute myelofibrosis
0.479 0.521 0.000
C94.4 Acute panmyelosis
0.479 0.521 0.000
C94.3 Mast cell leukaemia
0.479 0.521 0.000
C94.2 Acute megakaryoblastic leukaemia
0.479 0.521 0.000
C94.1 Chronic erythraemia
0.479 0.521 0.000
C94.0 Acute erythraemia and erythroleukaemia
0.479 0.521 0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.479 0.521 0.000
C96.8 Histiocytic sarcoma
0.479 0.521 0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.479 0.521 0.000
C96.6 Unifocal Langerhans-cell histiocytosis
0.479 0.521 0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.479 0.521 0.000
C96.4 Sarcoma of dendritic cells (accessory cells)
0.479 0.521 0.000
C96.3 True histiocytic lymphoma
0.479 0.521 0.000
C96.2 Malignant mast cell tumour
0.479 0.521 0.000
C96.1 Malignant histiocytosis
0.479 0.521 0.000
C96.0 Letterer-Siwe disease
0.479 0.521 0.000
E21.0 Primary hyperparathyroidism
0.477 0.523 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.474 0.526 0.000
E79 Disorders of purine and pyrimidine metabolism
0.471 0.529 0.000
E51.9 Thiamine deficiency, unspecified
0.469 0.530 0.000
E51.8 Other manifestations of thiamine deficiency
0.469 0.530 0.000
E51.1 Beriberi
0.469 0.530 0.000
C84.9 Mature T/NK-cell lymphoma, unspecified
0.467 0.533 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.467 0.533 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.467 0.533 0.000
C84.3 Lymphoepithelioid lymphoma
0.467 0.533 0.000
C84.2 T-zone lymphoma
0.467 0.533 0.000
C84.1 Sezary's diease
0.467 0.533 0.000
C84.0 Mycosis fungoides
0.467 0.533 0.000
C93.9 Monocytic leukaemia, unspecified
0.466 0.533 0.000
C93.7 Other monocytic leukaemia
0.466 0.533 0.000
C93.3 Juvenile myelomonocytic leukaemia
0.466 0.533 0.000
C93.2 Subacute monocytic leukaemia
0.466 0.533 0.000
C93.0 Acute monocytic leukaemia
0.466 0.533 0.000
E24.8 Other Cushing's syndrome
0.466 0.534 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.466 0.534 0.000
E24.3 Ectopic ACTH syndrome
0.466 0.534 0.000
E24.1 Nelson's syndrome
0.466 0.534 0.000
M35.1 Other overlap syndromes
0.461 0.539 0.000
E65-E68 Obesity and other hyperalimentation
0.461 0.539 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.461 0.539 0.000
E23.1 Drug-induced hypopituitarism
0.461 0.539 0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.460 0.540 0.000
C86.4 Blastic NK-cell lymphoma
0.460 0.540 0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.460 0.540 0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.460 0.540 0.000
C86.1 Hepatosplenic T-cell lymphoma
0.460 0.540 0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.460 0.540 0.000
M35.8 Other specified systemic involvement of connective tissue
0.460 0.540 0.000
E23.2 Diabetes insipidus
0.459 0.541 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.459 0.541 0.000
E88.2 Lipomatosis, not elsewhere classified
0.459 0.541 0.000
C95.1 Chronic leukaemia of unspecified cell type
0.455 0.545 0.000
E61.2 Magnesium deficiency
0.455 0.545 0.000
C84.5 Other and unspecified T-cell lymphomas
0.454 0.546 0.000
C91.9 Lymphoid leukaemia, unspecified
0.449 0.551 0.000
C93.1 Chronic monocytic leukaemia
0.448 0.551 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.448 0.552 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.443 0.556 0.000
E45 Retarded development following protein-energy malnutrition
0.443 0.556 0.000
E43 Unspecified severe protein-energy malnutrition
0.443 0.556 0.000
E42 Marasmic kwashiorkor
0.443 0.556 0.000
E41 Nutritional marasmus
0.443 0.556 0.000
E40 Kwashiorkor
0.443 0.556 0.000
E29 Testicular dysfunction
0.441 0.558 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.441 0.559 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.441 0.559 0.000
M35.5 Multifocal fibrosclerosis
0.441 0.559 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.441 0.559 0.000
E53 Deficiency of other B group vitamins
0.441 0.559 0.000
E11.3 With ophthalmic complications
0.440 0.560 0.000
L40.0 Psoriasis vulgaris
0.000 0.563 0.437
C95.7 Other leukaemia of unspecified cell type
0.434 0.566 0.000
C95.2 Subacute leukaemia of unspecified cell type
0.434 0.566 0.000
C95.0 Acute leukaemia of unspecified cell type
0.434 0.566 0.000
C86.5 Angioimmunoblastic T-cell lymphoma
0.433 0.566 0.000
C92 Myeloid leukaemia
0.432 0.568 0.000
E11.0 With coma
0.432 0.568 0.000
E11.2 With renal complications
0.425 0.575 0.000
E27.5 Adrenomedullary hyperfunction
0.424 0.576 0.000
E27.0 Other adrenocortical overactivity
0.424 0.576 0.000
E73.8 Other lactose intolerance
0.423 0.576 0.000
E73.1 Secondary lactase deficiency
0.423 0.576 0.000
E73.0 Congenital lactase deficiency
0.423 0.576 0.000
E31.0 Autoimmune polyglandular failure
0.418 0.581 0.000
E24.9 Cushing's syndrome, unspecified
0.415 0.585 0.000
E88.8 Other specified metabolic disorders
0.415 0.585 0.000
E11.6 With other specified complications
0.414 0.586 0.000
M35.2 Behcet's disease
0.413 0.587 0.000
C84.4 Peripheral T-cell lymphoma
0.412 0.588 0.000
E61.9 Deficiency of nutrient element, unspecified
0.407 0.593 0.000
E61.8 Deficiency of other specified nutrient elements
0.407 0.593 0.000
E61.7 Deficiency of multiple nutrient elements
0.407 0.593 0.000
E61.6 Vanadium deficiency
0.407 0.593 0.000
E61.5 Molybdenum deficiency
0.407 0.593 0.000
E61.4 Chromium deficiency
0.407 0.593 0.000
E61.3 Manganese deficiency
0.407 0.593 0.000
E61.0 Copper deficiency
0.407 0.593 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.407 0.593 0.000
E84.9 Cystic fibrosis, unspecified
0.405 0.594 0.000
E13.9 Without complications
0.404 0.596 0.000
E28.3 Primary ovarian failure
0.403 0.597 0.000
E31.9 Polyglandular dysfunction, unspecified
0.403 0.597 0.000
E31.8 Other polyglandular dysfunction
0.403 0.597 0.000
E31.1 Polyglandular hyperfunction
0.403 0.597 0.000
C91.0 Acute lymphoblastic leukaemia
0.402 0.598 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.401 0.599 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.399 0.601 0.000
E50.9 Vitamin A deficiency, unspecified
0.394 0.606 0.000
E50.8 Other manifestations of vitamin A deficiency
0.394 0.606 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.394 0.606 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.394 0.606 0.000
E50.5 Vitamin A deficiency with night blindness
0.394 0.606 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.394 0.606 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.394 0.606 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.394 0.606 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.394 0.606 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.394 0.606 0.000
E63.9 Nutritional deficiency, unspecified
0.394 0.606 0.000
E63.8 Other specified nutritional deficiencies
0.394 0.606 0.000
E63.1 Imbalance of constituents of food intake
0.394 0.606 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.394 0.606 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.394 0.606 0.000
E64.8 Sequelae of other nutritional deficiencies
0.394 0.606 0.000
E64.3 Sequelae of rickets
0.394 0.606 0.000
E64.2 Sequelae of vitamin C deficiency
0.394 0.606 0.000
E64.1 Sequelae of vitamin A deficiency
0.394 0.606 0.000
E64.0 Sequelae of protein-energy malnutrition
0.394 0.606 0.000
N05 Unspecified nephritic syndrome
0.393 0.607 0.000
E30.9 Disorder of puberty, unspecified
0.391 0.608 0.000
E30.8 Other disorders of puberty
0.391 0.608 0.000
E30.1 Precocious puberty
0.391 0.608 0.000
E30.0 Delayed puberty
0.391 0.608 0.000
E32.9 Disease of thymus, unspecified
0.391 0.608 0.000
E32.8 Other diseases of thymus
0.391 0.608 0.000
E32.1 Abscess of thymus
0.391 0.608 0.000
E32.0 Persistent hyperplasia of thymus
0.391 0.608 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.391 0.608 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.391 0.608 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.391 0.608 0.000
E11.1 With ketoacidosis
0.390 0.610 0.000
E22.1 Hyperprolactinaemia
0.389 0.611 0.000
E89.2 Postprocedural hypoparathyroidism
0.389 0.611 0.000
C91.8 Mature B-cell leukaemia Burkitt-type
0.388 0.612 0.000
C91.7 Other lymphoid leukaemia
0.388 0.612 0.000
C91.6 Prolymphocytic leukaemia of T-cell type
0.388 0.612 0.000
C91.3 Prolymphocytic leukaemia
0.388 0.612 0.000
C91.2 Subacute lymphocytic leukaemia
0.388 0.612 0.000
N05.2 Diffuse membranous glomerulonephritis
0.388 0.612 0.000
E27.9 Disorder of adrenal gland, unspecified
0.386 0.614 0.000
E55.0 Rickets, active
0.384 0.616 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.380 0.620 0.000
E74.8 Other specified disorders of carbohydrate metabolism
0.380 0.620 0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.380 0.620 0.000
E74.2 Disorders of galactose metabolism
0.380 0.620 0.000
E74.1 Disorders of fructose metabolism
0.380 0.620 0.000
E74.0 Glycogen storage disease
0.380 0.620 0.000
E72.0 Disorders of amino-acid transport
0.379 0.620 0.000
E84.8 Cystic fibrosis with other manifestations
0.379 0.620 0.000
E84.1 Cystic fibrosis with intestinal manifestations
0.379 0.620 0.000
E84.0 Cystic fibrosis with pulmonary manifestations
0.379 0.620 0.000
E88.3 Tumour lysis syndrome
0.377 0.623 0.000
E88.1 Lipodystrophy, not elsewhere classified
0.377 0.623 0.000
C90.1 Plasma cell leukaemia
0.377 0.623 0.000
C91.5 Adult T-cell leukaemia
0.375 0.625 0.000
C91.4 Hairy-cell leukaemia
0.375 0.625 0.000
N00-N08 Glomerular diseases
0.375 0.625 0.000
E11.7 With multiple complications
0.374 0.626 0.000
N04 Nephrotic syndrome
0.373 0.627 0.000
E55.9 Vitamin D deficiency, unspecified
0.371 0.629 0.000
E26.9 Hyperaldosteronism, unspecified
0.371 0.629 0.000
E72.9 Disorder of amino-acid metabolism, unspecified
0.369 0.631 0.000
E72.8 Other specified disorders of amino-acid metabolism
0.369 0.631 0.000
E72.5 Disorders of glycine metabolism
0.369 0.631 0.000
E72.4 Disorders of ornithine metabolism
0.369 0.631 0.000
E72.3 Disorders of lysine and hydroxylysine metabolism
0.369 0.631 0.000
E72.2 Disorders of urea cycle metabolism
0.369 0.631 0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.369 0.631 0.000
N05.9 Unspecified
0.367 0.633 0.000
C82.0 Small cleaved cell, follicular
0.367 0.633 0.000
C82.6 Cutaneous follicle centre lymphoma
0.366 0.634 0.000
C82.5 Diffuse follicle centre lymphoma
0.366 0.634 0.000
E88.9 Metabolic disorder, unspecified
0.365 0.635 0.000
E61.1 Iron deficiency
0.364 0.636 0.000
C82.1 Mixed small cleaved and large cell, follicular
0.363 0.637 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.361 0.639 0.000
E70.8 Other disorders of aromatic amino-acid metabolism
0.361 0.639 0.000
E70.3 Albinism
0.361 0.639 0.000
E70.2 Disorders of tyrosine metabolism
0.361 0.639 0.000
E70.1 Other hyperphenylalaninaemias
0.361 0.639 0.000
E70.0 Classical phenylketonuria
0.361 0.639 0.000
E71.3 Disorders of fatty-acid metabolism
0.361 0.639 0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.361 0.639 0.000
E71.1 Other disorders of branched-chain amino-acid metabolism
0.361 0.639 0.000
E71.0 Maple-syrup-urine disease
0.361 0.639 0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.361 0.639 0.000
E76.8 Other disorders of glucosaminoglycan metabolism
0.361 0.639 0.000
E76.3 Mucopolysaccharidosis, unspecified
0.361 0.639 0.000
E76.2 Other mucopolysaccharidoses
0.361 0.639 0.000
E76.1 Mucopolysaccharidosis, type II
0.361 0.639 0.000
E76.0 Mucopolysaccharidosis, type I
0.361 0.639 0.000
E77.9 Disorder of glycoprotein metabolism, unspecified
0.361 0.639 0.000
E77.8 Other disorders of glycoprotein metabolism
0.361 0.639 0.000
E77.1 Defects in glycoprotein degradation
0.361 0.639 0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.361 0.639 0.000
E56.9 Vitamin deficiency, unspecified
0.360 0.640 0.000
E56.8 Deficiency of other vitamins
0.360 0.640 0.000
E56.0 Deficiency of vitamin E
0.360 0.640 0.000
N04.9 Unspecified
0.359 0.641 0.000
E20.8 Other hypoparathyroidism
0.356 0.644 0.000
E20.1 Pseudohypoparathyroidism
0.356 0.644 0.000
E20.0 Idiopathic hypoparathyroidism
0.356 0.644 0.000
L40.8 Other psoriasis
0.000 0.647 0.353
L40.1 Generalised pustular psoriasis
0.000 0.648 0.352
C82.4 Follicular lymphoma grade IIIb
0.351 0.649 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.349 0.651 0.000
E22.8 Other hyperfunction of pituitary gland
0.349 0.651 0.000
E28.9 Ovarian dysfunction, unspecified
0.348 0.652 0.000
E28.8 Other ovarian dysfunction
0.348 0.652 0.000
E28.1 Androgen excess
0.348 0.652 0.000
E28.0 Oestrogen excess
0.348 0.652 0.000
L40.4 Guttate psoriasis
0.000 0.652 0.348
L40.2 Acrodermatitis continua
0.000 0.652 0.348
E26.8 Other hyperaldosteronism
0.348 0.652 0.000
E26.1 Secondary hyperaldosteronism
0.348 0.652 0.000
C83.0 Small cell (diffuse)
0.346 0.654 0.001
E75.6 Lipid storage disorder, unspecified
0.345 0.654 0.000
E75.4 Neuronal ceroid lipofuscinosis
0.345 0.654 0.000
E75.3 Sphingolipidosis, unspecified
0.345 0.654 0.000
E75.2 Other sphingolipidosis
0.345 0.654 0.000
E75.1 Other gangliosidosis
0.345 0.654 0.000
E75.0 GM2 gangliosidosis
0.345 0.654 0.000
E25.9 Adrenogenital disorder, unspecified
0.345 0.654 0.000
E25.8 Other adrenogenital disorders
0.345 0.654 0.000
E46 Unspecified protein-energy malnutrition
0.345 0.655 0.000
C82.2 Large cell, follicular
0.342 0.658 0.000
C82.3 Follicular lymphoma grade IIIa
0.341 0.659 0.000
E65 Localised adiposity
0.341 0.659 0.000
E83 Disorders of mineral metabolism
0.338 0.659 0.002
N05.1 Focal and segmental glomerular lesions
0.339 0.661 0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.338 0.662 0.000
E79.8 Other disorders of purine and pyrimidine metabolism
0.338 0.662 0.000
E79.1 Lesch-Nyhan syndrome
0.338 0.662 0.000
C95.9 Leukaemia, unspecified
0.336 0.663 0.000
C92.1 Chronic myeloid leukaemia
0.335 0.665 0.000
E53.9 Vitamin B deficiency, unspecified
0.334 0.666 0.000
C90.3 Solitary plasmacytoma
0.333 0.667 0.000
E67 Other hyperalimentation
0.331 0.669 0.000
E68 Sequelae of hyperalimentation
0.331 0.669 0.000
L40.3 Pustulosis palmaris et plantaris
0.000 0.669 0.330
N05.5 Diffuse mesangiocapillary glomerulonephritis
0.330 0.670 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.330 0.670 0.000
N04.2 Diffuse membranous glomerulonephritis
0.327 0.673 0.000
N04.1 Focal and segmental glomerular lesions
0.326 0.673 0.000
E89.3 Postprocedural hypopituitarism
0.324 0.675 0.000
E75.5 Other lipid storage disorders
0.324 0.676 0.000
E11.8 With unspecified complications
0.322 0.678 0.000
M35.3 Polymyalgia rheumatica
0.320 0.680 0.000
E44.1 Mild protein-energy malnutrition
0.318 0.682 0.000
E44.0 Moderate protein-energy malnutrition
0.318 0.682 0.000
E29.9 Testicular dysfunction, unspecified
0.317 0.683 0.000
E29.8 Other testicular dysfunction
0.317 0.683 0.000
E29.0 Testicular hyperfunction
0.317 0.683 0.000
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.316 0.684 0.000
E53.1 Pyridoxine deficiency
0.316 0.684 0.000
E53.0 Riboflavin deficiency
0.316 0.684 0.000
E56.1 Deficiency of vitamin K
0.313 0.687 0.000
E11.9 Without complications
0.310 0.690 0.000
E34 Other endocrine disorders
0.310 0.690 0.001
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.310 0.690 0.000
C92.7 Other myeloid leukaemia
0.310 0.690 0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.310 0.690 0.000
C92.5 Acute myelomonocytic leukaemia
0.310 0.690 0.000
C92.3 Myeloid sarcoma
0.310 0.690 0.000
C92.2 Subacute myeloid leukaemia
0.310 0.690 0.000
E20.9 Hypoparathyroidism, unspecified
0.306 0.694 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.306 0.694 0.000
C90.2 Plasmacytoma, extramedullary
0.305 0.695 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.302 0.698 0.000
E83.5 Disorders of calcium metabolism
0.298 0.702 0.000
N05.8 Other
0.294 0.706 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.290 0.710 0.000
N05.6 Dense deposit disease
0.282 0.718 0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis
0.282 0.718 0.000
N05.0 Minor glomerular abnormality
0.282 0.718 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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