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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2857136
log Bayes Factor = 29.8937
Chromosome 6   position 32,775,686  (GRCh37) Explore rs2857136 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E20-E35 Disorders of other endocrine glands
0.000 0.001 0.999
L40 Psoriasis
0.000 0.001 0.999
C44.6 Skin of upper limb, including shoulder
0.000 0.001 0.999
C44.7 Skin of lower limb, including hip
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.002 0.998
C44.3 Skin of other and unspecified parts of face
0.000 0.002 0.998
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E23 Hypofunction and other disorders of pituitary gland
0.000 0.013 0.987
C44.4 Skin of scalp and neck
0.000 0.020 0.980
L57.0 Actinic keratosis
0.000 0.021 0.979
E27 Other disorders of adrenal gland
0.000 0.028 0.972
G35-G37 Demyelinating diseases of the central nervous system
0.963 0.037 0.000
G37 Other demyelinating diseases of central nervous system
0.951 0.049 0.000
C44.2 Skin of ear and external auricular canal
0.000 0.053 0.947
E23.7 Disorder of pituitary gland, unspecified
0.000 0.059 0.941
E10.9 Without complications
0.000 0.066 0.934
E27.1 Primary adrenocortical insufficiency
0.000 0.070 0.930
J45.9 Asthma, unspecified
0.929 0.071 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.928 0.072 0.000
E23.6 Other disorders of pituitary gland
0.000 0.072 0.928
E10.2 With renal complications
0.000 0.081 0.919
E10.5 With peripheral circulatory complications
0.000 0.088 0.912
E10.1 With ketoacidosis
0.000 0.098 0.902
E24 Cushing's syndrome
0.000 0.105 0.895
G37.8 Other specified demyelinating diseases of central nervous system
0.872 0.128 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.152 0.848
L40-L45 Papulosquamous disorders
0.000 0.154 0.846
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.161 0.839
E28 Ovarian dysfunction
0.000 0.165 0.835
J45 Asthma
0.834 0.166 0.000
L40.3 Pustulosis palmaris et plantaris
0.000 0.171 0.829
L40.1 Generalised pustular psoriasis
0.000 0.187 0.813
J45.0 Predominantly allergic asthma
0.809 0.191 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.201 0.799
E23.0 Hypopituitarism
0.000 0.205 0.795
E83.1 Disorders of iron metabolism
0.795 0.205 0.000
C44.0 Skin of lip
0.000 0.209 0.791
G36 Other acute disseminated demyelination
0.785 0.215 0.000
E10.4 With neurological complications
0.000 0.219 0.781
E10.0 With coma
0.000 0.219 0.781
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.220 0.780
M07.3 Other psoriatic arthropathies
0.000 0.228 0.772
L40.4 Guttate psoriasis
0.000 0.229 0.771
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.231 0.769
E13 Other specified diabetes mellitus
0.000 0.233 0.767
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.236 0.764
E29 Testicular dysfunction
0.000 0.245 0.755
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.246 0.754
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.252 0.748
E06 Thyroiditis
0.000 0.259 0.741
E24.0 Pituitary-dependent Cushing's disease
0.000 0.259 0.741
E26 Hyperaldosteronism
0.000 0.260 0.740
E24.2 Drug-induced Cushing's syndrome
0.000 0.266 0.734
E70-E90 Metabolic disorders
0.000 0.267 0.733
L40.0 Psoriasis vulgaris
0.000 0.267 0.733
E11 Non-insulin-dependent diabetes mellitus
0.000 0.270 0.730
L43 Lichen planus
0.000 0.270 0.730
C44.8 Overlapping lesion of skin
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.716
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.284 0.716
E32 Diseases of thymus
0.000 0.284 0.716
E31 Polyglandular dysfunction
0.000 0.284 0.716
E30 Disorders of puberty, not elsewhere classified
0.000 0.284 0.716
L40.2 Acrodermatitis continua
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.289 0.711
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.290 0.710
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.291 0.709
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.292 0.708
E23.1 Drug-induced hypopituitarism
0.000 0.292 0.708
E28.2 Polycystic ovarian syndrome
0.000 0.296 0.703
E11.3 With ophthalmic complications
0.000 0.297 0.703
E24.9 Cushing's syndrome, unspecified
0.000 0.298 0.702
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.300 0.700
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.301 0.699
E27.5 Adrenomedullary hyperfunction
0.000 0.303 0.697
E27.0 Other adrenocortical overactivity
0.000 0.303 0.697
E27.9 Disorder of adrenal gland, unspecified
0.000 0.309 0.691
G37.5 Concentric sclerosis [Balo]
0.682 0.318 0.000
G37.4 Subacute necrotising myelitis
0.682 0.318 0.000
G37.2 Central pontine myelinolysis
0.682 0.318 0.000
G37.1 Central demyelination of corpus callosum
0.682 0.318 0.000
G37.0 Diffuse sclerosis
0.682 0.318 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.319 0.681
E21.3 Hyperparathyroidism, unspecified
0.000 0.320 0.680
E25 Adrenogenital disorders
0.000 0.326 0.673
E34 Other endocrine disorders
0.000 0.329 0.671
E89.0 Postprocedural hypothyroidism
0.000 0.333 0.667
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.333 0.667
E65-E68 Obesity and other hyperalimentation
0.000 0.335 0.665
E05.8 Other thyrotoxicosis
0.000 0.336 0.664
E10.6 With other specified complications
0.000 0.342 0.658
E78.2 Mixed hyperlipidaemia
0.000 0.342 0.658
G36.0 Neuromyelitis optica [Devic]
0.658 0.342 0.000
E40-E46 Malnutrition
0.000 0.348 0.652
E78.5 Hyperlipidaemia, unspecified
0.000 0.348 0.652
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.355 0.645
E24.8 Other Cushing's syndrome
0.000 0.358 0.642
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.358 0.642
E24.3 Ectopic ACTH syndrome
0.000 0.358 0.642
E24.1 Nelson's syndrome
0.000 0.358 0.642
E23.2 Diabetes insipidus
0.000 0.362 0.638
J45.8 Mixed asthma
0.637 0.363 0.000
E06.3 Autoimmune thyroiditis
0.000 0.370 0.630
E27.8 Other specified disorders of adrenal gland
0.000 0.375 0.625
E28.3 Primary ovarian failure
0.000 0.375 0.625
L43.9 Lichen planus, unspecified
0.000 0.375 0.625
E78.6 Lipoprotein deficiency
0.000 0.377 0.623
J45.1 Nonallergic asthma
0.622 0.378 0.000
E27.2 Addisonian crisis
0.000 0.385 0.614
E20 Hypoparathyroidism
0.000 0.388 0.612
E88 Other metabolic disorders
0.000 0.390 0.610
E04 Other non-toxic goitre
0.000 0.392 0.608
L44 Other papulosquamous disorders
0.000 0.394 0.606
L41 Parapsoriasis
0.000 0.394 0.606
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.394 0.606
E11.2 With renal complications
0.000 0.398 0.602
L57.5 Actinic granuloma
0.000 0.398 0.602
L57.3 Poikiloderma of Civatte
0.000 0.398 0.602
L57.2 Cutis rhomboidalis nuchae
0.000 0.398 0.602
L57.1 Actinic reticuloid
0.000 0.398 0.602
E28.9 Ovarian dysfunction, unspecified
0.000 0.401 0.599
E28.8 Other ovarian dysfunction
0.000 0.401 0.599
E28.1 Androgen excess
0.000 0.401 0.599
E28.0 Oestrogen excess
0.000 0.401 0.599
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.405 0.594
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.592 0.408 0.000
E13.9 Without complications
0.000 0.412 0.588
E10.8 With unspecified complications
0.000 0.415 0.585
E78.1 Pure hyperglyceridaemia
0.000 0.417 0.583
E11.0 With coma
0.000 0.419 0.581
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.420 0.580
E29.1 Testicular hypofunction
0.000 0.421 0.579
E16 Other disorders of pancreatic internal secretion
0.000 0.422 0.578
E65 Localised adiposity
0.000 0.428 0.572
E79 Disorders of purine and pyrimidine metabolism
0.000 0.430 0.570
L43.8 Other lichen planus
0.000 0.433 0.566
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.434 0.566
E13.3 With ophthalmic complications
0.000 0.435 0.565
G36.9 Acute disseminated demyelination, unspecified
0.563 0.437 0.000
G36.8 Other specified acute disseminated demyelination
0.563 0.437 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.563 0.437 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.441 0.559
E89.3 Postprocedural hypopituitarism
0.000 0.441 0.559
E21.2 Other hyperparathyroidism
0.000 0.444 0.556
E22 Hyperfunction of pituitary gland
0.000 0.445 0.555
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.446 0.554
E26.0 Primary hyperaldosteronism
0.000 0.446 0.554
M07.38 Other psoriatic arthropathies (Other)
0.000 0.446 0.553
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.446 0.553
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.446 0.553
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.446 0.553
E13.8 With unspecified complications
0.000 0.450 0.550
E13.7 With multiple complications
0.000 0.450 0.550
E13.6 With other specified complications
0.000 0.450 0.550
E13.5 With peripheral circulatory complications
0.000 0.450 0.550
E13.4 With neurological complications
0.000 0.450 0.550
E13.2 With renal complications
0.000 0.450 0.550
E13.1 With ketoacidosis
0.000 0.450 0.550
E13.0 With coma
0.000 0.450 0.550
E34.8 Other specified endocrine disorders
0.000 0.450 0.549
E04.0 Non-toxic diffuse goitre
0.000 0.455 0.545
E06.5 Other chronic thyroiditis
0.000 0.456 0.544
E29.9 Testicular dysfunction, unspecified
0.000 0.459 0.541
E29.8 Other testicular dysfunction
0.000 0.459 0.541
E29.0 Testicular hyperfunction
0.000 0.459 0.541
E15 Nondiabetic hypoglycaemic coma
0.000 0.459 0.541
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.462 0.538
E84 Cystic fibrosis
0.000 0.462 0.538
L55 Sunburn
0.000 0.464 0.536
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.468 0.532
E06.4 Drug-induced thyroiditis
0.000 0.468 0.532
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.468 0.532
E06.0 Acute thyroiditis
0.000 0.468 0.532
E26.9 Hyperaldosteronism, unspecified
0.000 0.469 0.530
E26.8 Other hyperaldosteronism
0.000 0.469 0.530
E26.1 Secondary hyperaldosteronism
0.000 0.469 0.530
E77 Disorders of glycoprotein metabolism
0.000 0.474 0.526
E76 Disorders of glycosaminoglycan metabolism
0.000 0.474 0.526
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.474 0.526
E70 Disorders of aromatic amino-acid metabolism
0.000 0.474 0.526
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.474 0.526
L40.8 Other psoriasis
0.000 0.476 0.524
E11.7 With multiple complications
0.000 0.476 0.524
L43.3 Subacute (active) lichen planus
0.000 0.477 0.523
L43.2 Lichenoid drug reaction
0.000 0.477 0.523
L43.1 Bullous lichen planus
0.000 0.477 0.523
L43.0 Hypertrophic lichen planus
0.000 0.477 0.523
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.481 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
L42 Pityriasis rosea
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.486 0.514
E30.8 Other disorders of puberty
0.000 0.486 0.514
E30.1 Precocious puberty
0.000 0.486 0.514
E30.0 Delayed puberty
0.000 0.486 0.514
E31.9 Polyglandular dysfunction, unspecified
0.000 0.486 0.514
E31.8 Other polyglandular dysfunction
0.000 0.486 0.514
E31.1 Polyglandular hyperfunction
0.000 0.486 0.514
E31.0 Autoimmune polyglandular failure
0.000 0.486 0.514
E32.9 Disease of thymus, unspecified
0.000 0.486 0.514
E32.8 Other diseases of thymus
0.000 0.486 0.514
E32.1 Abscess of thymus
0.000 0.486 0.514
E32.0 Persistent hyperplasia of thymus
0.000 0.486 0.514
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.486 0.514
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.486 0.514
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.513
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.488 0.512
E06.9 Thyroiditis, unspecified
0.000 0.489 0.511
E11.6 With other specified complications
0.000 0.492 0.508
E88.3 Tumour lysis syndrome
0.000 0.493 0.507
E11.8 With unspecified complications
0.000 0.495 0.505
E89.4 Postprocedural ovarian failure
0.000 0.497 0.503
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.497 0.503
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.498 0.502
E89.5 Postprocedural testicular hypofunction
0.000 0.498 0.502
E88.8 Other specified metabolic disorders
0.000 0.498 0.502
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.501 0.499
L58 Radiodermatitis
0.000 0.508 0.492
E25.9 Adrenogenital disorder, unspecified
0.000 0.517 0.483
E25.8 Other adrenogenital disorders
0.000 0.517 0.483
E34.5 Androgen resistance syndrome
0.000 0.518 0.481
E34.4 Constitutional tall stature
0.000 0.518 0.481
E34.3 Short stature, not elsewhere classified
0.000 0.518 0.481
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.518 0.481
E34.1 Other hypersecretion of intestinal hormones
0.000 0.518 0.481
E67 Other hyperalimentation
0.000 0.523 0.477
E68 Sequelae of hyperalimentation
0.000 0.523 0.477
L10-L14 Bullous disorders
0.000 0.527 0.473
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.529 0.470
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.530 0.469
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.531 0.469
E89.1 Postprocedural hypoinsulinaemia
0.000 0.532 0.468
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.532 0.467
E45 Retarded development following protein-energy malnutrition
0.000 0.532 0.467
E43 Unspecified severe protein-energy malnutrition
0.000 0.532 0.467
E42 Marasmic kwashiorkor
0.000 0.532 0.467
E41 Nutritional marasmus
0.000 0.532 0.467
E40 Kwashiorkor
0.000 0.532 0.467
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.534 0.466
E88.2 Lipomatosis, not elsewhere classified
0.000 0.535 0.465
E78.4 Other hyperlipidaemia
0.000 0.536 0.464
E89.2 Postprocedural hypoparathyroidism
0.000 0.542 0.458
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.547 0.453
E78.3 Hyperchylomicronaemia
0.000 0.547 0.453
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.549 0.451
E72 Other disorders of amino-acid metabolism
0.000 0.550 0.450
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.560 0.440
E85 Amyloidosis
0.000 0.560 0.440
E74 Other disorders of carbohydrate metabolism
0.000 0.561 0.439
E20.1 Pseudohypoparathyroidism
0.000 0.561 0.439
E20.0 Idiopathic hypoparathyroidism
0.000 0.561 0.439
E73 Lactose intolerance
0.000 0.561 0.439
E04.8 Other specified non-toxic goitre
0.000 0.564 0.436
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.565 0.435
E04.2 Non-toxic multinodular goitre
0.000 0.565 0.435
L41.9 Parapsoriasis, unspecified
0.000 0.565 0.435
L41.8 Other parapsoriasis
0.000 0.565 0.435
L41.5 Retiform parapsoriasis
0.000 0.565 0.435
L41.4 Large plaque parapsoriasis
0.000 0.565 0.435
L41.3 Small plaque parapsoriasis
0.000 0.565 0.435
L41.2 Lymphomatoid papulosis
0.000 0.565 0.435
L41.1 Pityriasis lichenoides chronica
0.000 0.565 0.435
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.565 0.435
L44.9 Papulosquamous disorder, unspecified
0.000 0.565 0.435
L44.8 Other specified papulosquamous disorders
0.000 0.565 0.435
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.565 0.435
L44.3 Lichen ruber moniliformis
0.000 0.565 0.435
L44.2 Lichen striatus
0.000 0.565 0.435
L44.1 Lichen nitidus
0.000 0.565 0.435
L44.0 Pityriasis rubra pilaris
0.000 0.565 0.435
L57.4 Cutis laxa senilis
0.000 0.565 0.434
E07 Other disorders of thyroid
0.000 0.568 0.432
E34.9 Endocrine disorder, unspecified
0.000 0.568 0.432
E16.2 Hypoglycaemia, unspecified
0.000 0.569 0.431
E78.8 Other disorders of lipoprotein metabolism
0.000 0.572 0.428
E88.9 Metabolic disorder, unspecified
0.000 0.577 0.423
E80.4 Gilbert's syndrome
0.000 0.582 0.418
L56.3 Solar urticaria
0.000 0.584 0.416
L56.2 Photocontact dermatitis [berloque dermatitis]
0.000 0.584 0.416
L56.1 Drug photoallergic response
0.000 0.584 0.416
L56.0 Drug phototoxic response
0.000 0.584 0.416
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.586 0.414
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.586 0.414
E16.4 Abnormal secretion of gastrin
0.000 0.586 0.414
E16.3 Increased secretion of glucagon
0.000 0.586 0.414
E20.9 Hypoparathyroidism, unspecified
0.000 0.588 0.411
E21.0 Primary hyperparathyroidism
0.000 0.590 0.410
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.591 0.409
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.591 0.409
E79.1 Lesch-Nyhan syndrome
0.000 0.591 0.409
C44.9 Malignant neoplasm of skin, unspecified
0.001 0.592 0.408
E06.1 Subacute thyroiditis
0.000 0.595 0.404
E46 Unspecified protein-energy malnutrition
0.000 0.597 0.403
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.602 0.398
E22.8 Other hyperfunction of pituitary gland
0.000 0.602 0.398
E84.9 Cystic fibrosis, unspecified
0.000 0.602 0.397
E16.1 Other hypoglycaemia
0.000 0.603 0.396
E22.1 Hyperprolactinaemia
0.000 0.604 0.396
E11.1 With ketoacidosis
0.000 0.605 0.395
E80.6 Other disorders of bilirubin metabolism
0.000 0.610 0.390
E11.5 With peripheral circulatory complications
0.000 0.612 0.388
E84.8 Cystic fibrosis with other manifestations
0.000 0.614 0.385
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.614 0.385
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.614 0.385
L55.9 Sunburn, unspecified
0.000 0.615 0.385
L55.8 Other sunburn
0.000 0.615 0.385
L55.2 Sunburn of third degree
0.000 0.615 0.385
L55.1 Sunburn of second degree
0.000 0.615 0.385
L55.0 Sunburn of first degree
0.000 0.615 0.385
L59.9 Disorder of skin and subcutaneous tissue related to radiation, unspecified
0.000 0.618 0.381
L59.0 Erythema ab igne [dermatitis ab igne]
0.000 0.618 0.381
E34.0 Carcinoid syndrome
0.000 0.620 0.380
L59.8 Other specified disorders of skin and subcutaneous tissue related to radiation
0.000 0.623 0.377
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.623 0.377
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.623 0.377
E70.3 Albinism
0.000 0.623 0.377
E70.2 Disorders of tyrosine metabolism
0.000 0.623 0.377
E70.1 Other hyperphenylalaninaemias
0.000 0.623 0.377
E70.0 Classical phenylketonuria
0.000 0.623 0.377
E71.3 Disorders of fatty-acid metabolism
0.000 0.623 0.377
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.623 0.377
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.623 0.377
E71.0 Maple-syrup-urine disease
0.000 0.623 0.377
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.623 0.377
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.623 0.377
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.623 0.377
E76.2 Other mucopolysaccharidoses
0.000 0.623 0.377
E76.1 Mucopolysaccharidosis, type II
0.000 0.623 0.377
E76.0 Mucopolysaccharidosis, type I
0.000 0.623 0.377
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.623 0.377
E77.8 Other disorders of glycoprotein metabolism
0.000 0.623 0.377
E77.1 Defects in glycoprotein degradation
0.000 0.623 0.377
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.623 0.377
L56.4 Polymorphous light eruption
0.000 0.624 0.376
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.626 0.374
E20.8 Other hypoparathyroidism
0.000 0.627 0.373
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.628 0.372
E80.5 Crigler-Najjar syndrome
0.000 0.628 0.372
E80.3 Defects of catalase and peroxydase
0.000 0.628 0.372
E80.0 Hereditary erythropoietic porphyria
0.000 0.628 0.372
E04.9 Non-toxic goitre, unspecified
0.000 0.636 0.364
E75.6 Lipid storage disorder, unspecified
0.000 0.639 0.360
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.639 0.360
E75.3 Sphingolipidosis, unspecified
0.000 0.639 0.360
E75.1 Other gangliosidosis
0.000 0.639 0.360
E75.0 GM2 gangliosidosis
0.000 0.639 0.360
E75.2 Other sphingolipidosis
0.000 0.647 0.353
L12 Pemphigoid
0.000 0.647 0.353
L58.1 Chronic radiodermatitis
0.000 0.647 0.353
L58.0 Acute radiodermatitis
0.000 0.647 0.353
E80.1 Porphyria cutanea tarda
0.000 0.651 0.349
E75.5 Other lipid storage disorders
0.000 0.654 0.345
E67.8 Other specified hyperalimentation
0.000 0.658 0.342
E67.3 Hypervitaminosis D
0.000 0.658 0.342
E67.2 Megavitamin-B6 syndrome
0.000 0.658 0.342
E67.1 Hypercarotenaemia
0.000 0.658 0.342
E67.0 Hypervitaminosis A
0.000 0.658 0.342
L10 Pemphigus
0.000 0.660 0.339
L14 Bullous disorders in diseases classified elsewhere
0.000 0.660 0.339
L11 Other acantholytic disorders
0.000 0.664 0.336
E44.1 Mild protein-energy malnutrition
0.000 0.664 0.335
E44.0 Moderate protein-energy malnutrition
0.000 0.664 0.335
E85.4 Organ-limited amyloidosis
0.000 0.666 0.334
E50-E64 Other nutritional deficiencies
0.000 0.672 0.328
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.677 0.322
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.677 0.322
E72.5 Disorders of glycine metabolism
0.000 0.677 0.322
E72.4 Disorders of ornithine metabolism
0.000 0.677 0.322
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.677 0.322
E72.2 Disorders of urea cycle metabolism
0.000 0.677 0.322
C44.5 Skin of trunk
0.000 0.679 0.321
E85.9 Amyloidosis, unspecified
0.000 0.683 0.317
E72.0 Disorders of amino-acid transport
0.000 0.683 0.317
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.684 0.316
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.684 0.316
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.684 0.316
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.685 0.315
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.685 0.315
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.685 0.315
E74.2 Disorders of galactose metabolism
0.000 0.685 0.315
E74.1 Disorders of fructose metabolism
0.000 0.685 0.315
E73.8 Other lactose intolerance
0.000 0.685 0.315
E73.1 Secondary lactase deficiency
0.000 0.685 0.315
E73.0 Congenital lactase deficiency
0.000 0.685 0.315
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.685 0.315
E74.0 Glycogen storage disease
0.000 0.688 0.312
L13 Other bullous disorders
0.000 0.689 0.311
E07.1 Dyshormogenetic goitre
0.000 0.690 0.310
E07.0 Hypersecretion of calcitonin
0.000 0.690 0.310
L58.9 Radiodermatitis, unspecified
0.000 0.691 0.309
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.697 0.303
E11.9 Without complications
0.000 0.700 0.300
E83 Disorders of mineral metabolism
0.083 0.700 0.217
E80.2 Other porphyria
0.000 0.702 0.298
E78.0 Pure hypercholesterolaemia
0.000 0.704 0.296
M07 Psoriatic and enteropathic arthropathies
0.000 0.707 0.293
L60-L75 Disorders of skin appendages
0.000 0.710 0.290
E03 Other hypothyroidism
0.000 0.718 0.282
E22.0 Acromegaly and pituitary gigantism
0.000 0.718 0.282
E07.8 Other specified disorders of thyroid
0.000 0.721 0.279
L12.9 Pemphigoid, unspecified
0.000 0.730 0.270
E85.8 Other amyloidosis
0.000 0.732 0.268
E51 Thiamine deficiency
0.000 0.739 0.261
E85.3 Secondary systemic amyloidosis
0.000 0.739 0.260
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.744 0.255
L71 Rosacea
0.000 0.745 0.255
L12.8 Other pemphigoid
0.000 0.747 0.253
L12.3 Acquired epidermolysis bullosa
0.000 0.747 0.253
L12.2 Chronic bullous disease of childhood
0.000 0.747 0.253
L12.1 Cicatricial pemphigoid
0.000 0.747 0.252
L12.0 Bullous pemphigoid
0.000 0.749 0.251
E56 Other vitamin deficiencies
0.000 0.754 0.246
L10.9 Pemphigus, unspecified
0.000 0.756 0.243
L10.8 Other pemphigus
0.000 0.756 0.243
L10.5 Drug-induced pemphigus
0.000 0.756 0.243
L10.4 Pemphigus erythematosus
0.000 0.756 0.243
L10.3 Brazilian pemphigus [fogo selvagem]
0.000 0.756 0.243
L10.2 Pemphigus foliaceus
0.000 0.756 0.243
L10.1 Pemphigus vegetans
0.000 0.756 0.243
L10.0 Pemphigus vulgaris
0.000 0.756 0.243
L11.0 Acquired keratosis follicularis
0.000 0.757 0.242
L11.9 Acantholytic disorder, unspecified
0.000 0.759 0.241
L11.8 Other specified acantholytic disorders
0.000 0.759 0.241
L50-L54 Urticaria and erythema
0.000 0.759 0.241
E11.4 With neurological complications
0.000 0.761 0.239
L11.1 Transient acantholytic dermatosis [Grover]
0.000 0.764 0.235
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.765 0.235
E50 Vitamin A deficiency
0.000 0.765 0.235
E60 Dietary zinc deficiency
0.000 0.765 0.235
E59 Dietary selenium deficiency
0.000 0.765 0.235
E52 Niacin deficiency [pellagra]
0.000 0.765 0.235
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.766 0.234
L68 Hypertrichosis
0.000 0.769 0.231
E73.9 Lactose intolerance, unspecified
0.000 0.772 0.228
E63 Other nutritional deficiencies
0.000 0.776 0.223
L13.9 Bullous disorder, unspecified
0.000 0.777 0.223
L13.8 Other specified bullous disorders
0.000 0.777 0.223
L13.1 Subcorneal pustular dermatitis
0.000 0.777 0.223
L71.9 Rosacea, unspecified
0.000 0.777 0.223
L66 Cicatricial alopecia [scarring hair loss]
0.000 0.780 0.220
E55 Vitamin D deficiency
0.000 0.783 0.217
E83.9 Disorder of mineral metabolism, unspecified
0.060 0.785 0.156
E83.8 Other disorders of mineral metabolism
0.060 0.785 0.156
E83.2 Disorders of zinc metabolism
0.060 0.785 0.156
E83.0 Disorders of copper metabolism
0.060 0.785 0.156
E51.2 Wernicke's encephalopathy
0.000 0.787 0.213
E54 Ascorbic acid deficiency
0.000 0.788 0.212
L63 Alopecia areata
0.000 0.788 0.211
M07.5 Arthropathy in ulcerative colitis
0.000 0.790 0.210
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.790 0.210
M07.2 Psoriatic spondylitis
0.000 0.790 0.210
M07.1 Arthritis mutilans
0.000 0.790 0.210
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.790 0.210
L75 Apocrine sweat disorders
0.000 0.792 0.208
L74 Eccrine sweat disorders
0.000 0.792 0.208
L67 Hair colour and hair shaft abnormalities
0.000 0.792 0.208
L64 Androgenic alopecia
0.000 0.792 0.208
L62 Nail disorders in diseases classified elsewhere
0.000 0.792 0.208
E58 Dietary calcium deficiency
0.000 0.794 0.205
E03.5 Myxoedema coma
0.000 0.797 0.202
E03.4 Atrophy of thyroid (acquired)
0.000 0.797 0.202
E03.3 Postinfectious hypothyroidism
0.000 0.797 0.202
L51 Erythema multiforme
0.000 0.801 0.199
L71.1 Rhinophyma
0.000 0.802 0.198
E03.1 Congenital hypothyroidism without goitre
0.000 0.802 0.197
L60 Nail disorders
0.000 0.804 0.196

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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