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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2858308
log Bayes Factor = 53.453
Chromosome 6   position 32,670,000  (GRCh37) Explore rs2858308 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
M35 Other systemic involvement of connective tissue
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.001 0.999
E03.9 Hypothyroidism, unspecified
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.001 0.999
M20-M25 Other joint disorders
0.000 0.001 0.999
H30-H36 Disorders of choroid and retina
0.000 0.002 0.998
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.003 0.997
M05 Seropositive rheumatoid arthritis
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.005 0.995
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.006 0.994
H04 Disorders of lachrymal system
0.000 0.007 0.993
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.008 0.992
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.016 0.984
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.017 0.983
H02 Other disorders of eyelid
0.000 0.018 0.982
L20-L30 Dermatitis and eczema
0.000 0.018 0.982
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.000 0.024 0.976
M35.0 Sicca syndrome [Sjogren]
0.000 0.024 0.976
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.025 0.975
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.026 0.974
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.027 0.973
E20-E35 Disorders of other endocrine glands
0.000 0.029 0.971
Chapter X Diseases of the respiratory system
0.000 0.029 0.971
J20-J22 Other acute lower respiratory infections
0.000 0.041 0.959
E27 Other disorders of adrenal gland
0.000 0.042 0.958
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.042 0.958
E11 Non-insulin-dependent diabetes mellitus
0.000 0.045 0.955
E11.3 With ophthalmic complications
0.000 0.049 0.951
H02.1 Ectropion of eyelid
0.000 0.050 0.950
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.051 0.949
J22 Unspecified acute lower respiratory infection
0.000 0.052 0.948
E27.1 Primary adrenocortical insufficiency
0.000 0.055 0.945
H02.0 Entropion and trichiasis of eyelid
0.000 0.058 0.942
L98.8 Other specified disorders of skin and subcutaneous tissue
0.000 0.063 0.937
M34 Systemic sclerosis
0.000 0.068 0.932
L30 Other dermatitis
0.000 0.075 0.925
E10.5 With peripheral circulatory complications
0.000 0.079 0.921
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.080 0.920
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.082 0.918
D50-D53 Nutritional anaemias
0.000 0.085 0.915
N48 Other disorders of penis
0.914 0.086 0.000
J80 Adult respiratory distress syndrome
0.000 0.089 0.911
N48.6 Balanitis xerotica obliterans
0.909 0.091 0.000
E10.4 With neurological complications
0.000 0.093 0.907
L81 Other disorders of pigmentation
0.000 0.094 0.906
M06.0 Seronegative rheumatoid arthritis
0.000 0.096 0.904
E06 Thyroiditis
0.000 0.097 0.903
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.102 0.898
D68 Other coagulation defects
0.000 0.104 0.896
J84 Other interstitial pulmonary diseases
0.000 0.107 0.893
L98.4 Chronic ulcer of skin, not elsewhere classified
0.000 0.107 0.893
H05 Disorders of orbit
0.000 0.110 0.890
E10.2 With renal complications
0.000 0.120 0.880
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.121 0.879
L30.9 Dermatitis, unspecified
0.000 0.124 0.876
E28 Ovarian dysfunction
0.000 0.128 0.872
N40-N51 Diseases of male genital organs
0.872 0.128 0.000
D60-D64 Aplastic and other anaemias
0.000 0.130 0.870
L27 Dermatitis due to substances taken internally
0.000 0.130 0.870
L81.4 Other melanin hyperpigmentation
0.000 0.132 0.868
N48.8 Other specified disorders of penis
0.868 0.132 0.000
M60-M63 Disorders of muscles
0.000 0.133 0.867
H04.2 Epiphora
0.000 0.134 0.866
M34.9 Systemic sclerosis, unspecified
0.000 0.136 0.864
N47 Redundant prepuce, phimosis and paraphimosis
0.864 0.136 0.000
L29 Pruritus
0.000 0.142 0.858
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.143 0.857
M31 Other necrotising vasculopathies
0.000 0.144 0.856
L98.0 Pyogenic granuloma
0.000 0.144 0.856
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.150 0.850
Chapter I Certain infectious and parasitic diseases
0.000 0.150 0.850
J95-J99 Other diseases of the respiratory system
0.000 0.151 0.849
E70-E90 Metabolic disorders
0.000 0.151 0.849
Chapter V Mental and behavioural disorders
0.000 0.153 0.847
H04.8 Other disorders of lachrymal system
0.000 0.154 0.846
M06.3 Rheumatoid nodule
0.000 0.156 0.844
N48.0 Leukoplakia of penis
0.843 0.157 0.000
D61 Other aplastic anaemias
0.000 0.159 0.841
J00-J06 Acute upper respiratory infections
0.000 0.162 0.838
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.163 0.837
L83 Acanthosis nigricans
0.000 0.164 0.836
D50 Iron deficiency anaemia
0.000 0.166 0.834
E06.3 Autoimmune thyroiditis
0.000 0.167 0.833
L57.0 Actinic keratosis
0.000 0.167 0.833
H53-H54 Visual disturbances and blindness
0.000 0.170 0.830
B35-B49 Mycoses
0.000 0.171 0.829
B37 Candidiasis
0.000 0.173 0.827
B37.8 Candidiasis of other sites
0.000 0.175 0.825
D61.9 Aplastic anaemia, unspecified
0.000 0.179 0.821
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.179 0.821
M35.1 Other overlap syndromes
0.000 0.181 0.819
F30-F39 Mood [affective] disorders
0.000 0.184 0.816
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.186 0.814
D68.5 Primary Thrombophilia
0.000 0.187 0.813
H02.9 Disorder of eyelid, unspecified
0.000 0.188 0.812
L94 Other localised connective tissue disorders
0.000 0.191 0.809
J00 Acute nasopharyngitis [common cold]
0.000 0.196 0.804
H55-H59 Other disorders of eye and adnexa
0.000 0.196 0.804
N45 Orchitis and epididymitis
0.802 0.198 0.000
L93 Lupus erythematosus
0.000 0.199 0.801
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.200 0.800
N48.9 Disorder of penis, unspecified
0.797 0.203 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.205 0.795
E20 Hypoparathyroidism
0.000 0.210 0.790
E27.8 Other specified disorders of adrenal gland
0.000 0.211 0.789
M62 Other disorders of muscle
0.000 0.214 0.786
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.000 0.215 0.785
H02.6 Xanthelasma of eyelid
0.000 0.216 0.784
E11.1 With ketoacidosis
0.000 0.219 0.780
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.220 0.780
L85 Other epidermal thickening
0.000 0.220 0.780
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.223 0.777
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.224 0.776
L29.0 Pruritus ani
0.000 0.225 0.775
L80 Vitiligo
0.000 0.225 0.775
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.226 0.774
D52 Folate deficiency anaemia
0.000 0.226 0.774
F31 Bipolar affective disorder
0.000 0.227 0.773
A50-A64 Infections with a predominantly sexual mode of transmission
0.000 0.228 0.772
E28.2 Polycystic ovarian syndrome
0.000 0.234 0.766
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.235 0.765
H05.2 Exophthalmic conditions
0.000 0.235 0.765
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.235 0.765
H04.4 Chronic inflammation of lachrymal passages
0.000 0.236 0.764
B37.0 Candidal stomatitis
0.000 0.237 0.763
E89.0 Postprocedural hypothyroidism
0.000 0.238 0.762
H53 Visual disturbances
0.000 0.239 0.761
M31.3 Wegener's granulomatosis
0.000 0.240 0.760
L30.8 Other specified dermatitis
0.000 0.240 0.760
J20 Acute bronchitis
0.000 0.240 0.760
L98.9 Disorder of skin and subcutaneous tissue, unspecified
0.000 0.240 0.760
D68.0 Von Willebrand's disease
0.000 0.241 0.759
E07 Other disorders of thyroid
0.000 0.241 0.759
D50.8 Other iron deficiency anaemias
0.000 0.242 0.758
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.243 0.757
E29 Testicular dysfunction
0.000 0.244 0.756
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess
0.755 0.245 0.000
D68.9 Coagulation defect, unspecified
0.000 0.245 0.755
N48.4 Impotence of organic origin
0.751 0.249 0.000
E10.6 With other specified complications
0.000 0.250 0.750
E11.2 With renal complications
0.000 0.250 0.750
M34.1 CR(E)ST syndrome
0.000 0.252 0.748
L20 Atopic dermatitis
0.000 0.252 0.748
M35.7 Hypermobility syndrome
0.000 0.253 0.747
M32 Systemic lupus erythematosus
0.000 0.254 0.746
E50-E64 Other nutritional deficiencies
0.000 0.255 0.745
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.256 0.744
J98 Other respiratory disorders
0.000 0.258 0.742
M62.8 Other specified disorders of muscle
0.000 0.260 0.740
M07 Psoriatic and enteropathic arthropathies
0.000 0.260 0.740
H05.0 Acute inflammation of orbit
0.000 0.262 0.738
M06.34 Rheumatoid nodule (Hand)
0.000 0.268 0.732
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.268 0.732
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.000 0.269 0.731
H53.9 Visual disturbance, unspecified
0.000 0.270 0.730
E04 Other non-toxic goitre
0.000 0.271 0.729
N48.5 Ulcer of penis
0.728 0.272 0.000
F32 Depressive episode
0.000 0.272 0.728
D68.8 Other specified coagulation defects
0.000 0.273 0.727
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.273 0.727
H04.9 Disorder of lachrymal system, unspecified
0.000 0.273 0.727
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.273 0.727
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.277 0.723
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.280 0.720
H06.2 Dysthyroid exophthalmos
0.000 0.280 0.720
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.000 0.281 0.719
M21 Other acquired deformities of limbs
0.000 0.281 0.719
E05.8 Other thyrotoxicosis
0.000 0.281 0.718
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M12 Other specific arthropathies
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.283 0.717
M35.8 Other specified systemic involvement of connective tissue
0.000 0.283 0.717
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.283 0.717
M35.5 Multifocal fibrosclerosis
0.000 0.283 0.717
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.283 0.717
M35.2 Behcet's disease
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.716
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.716
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.716
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.716
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.716
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.284 0.716
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.284 0.716
H30 Chorioretinal inflammation
0.000 0.284 0.716
J81 Pulmonary oedema
0.000 0.284 0.716
M05.8 Other seropositive rheumatoid arthritis
0.000 0.285 0.715
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.285 0.715
M05.2 Rheumatoid vasculitis
0.000 0.285 0.715
M05.1 Rheumatoid lung disease
0.000 0.285 0.715
M05.0 Felty's syndrome
0.000 0.285 0.715
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.286 0.714
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.286 0.714
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.286 0.714
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.286 0.714
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.286 0.714
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.286 0.714
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.286 0.714
D62 Acute posthaemorrhagic anaemia
0.000 0.287 0.713
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.288 0.712
H04.6 Other changes in lachrymal passages
0.000 0.288 0.712
H04.0 Dacryoadenitis
0.000 0.288 0.712
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.290 0.710
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.290 0.710
E27.2 Addisonian crisis
0.000 0.293 0.707
B07 Viral warts
0.000 0.293 0.707
H01 Other inflammation of eyelid
0.000 0.294 0.706
E28.3 Primary ovarian failure
0.000 0.294 0.706
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.294 0.705
L87 Transepidermal elimination disorders
0.000 0.294 0.705
L88 Pyoderma gangrenosum
0.000 0.294 0.705
L86 Keratoderma in diseases classified elsewhere
0.000 0.294 0.705
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.295 0.705
N41 Inflammatory diseases of prostate
0.705 0.295 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.296 0.704
L25 Unspecified contact dermatitis
0.000 0.296 0.704
L24 Irritant contact dermatitis
0.000 0.296 0.704
L21 Seborrhoeic dermatitis
0.000 0.296 0.704
L26 Exfoliative dermatitis
0.000 0.296 0.704
L22 Diaper [napkin] dermatitis
0.000 0.296 0.704
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.296 0.704
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.702 0.297 0.000
E14 Unspecified diabetes mellitus
0.000 0.299 0.701
D68.6 Other Thrombophilia
0.000 0.299 0.701
L98.7 Excessive and redundant skin and subcutaneous tissue
0.000 0.300 0.700
L98.6 Other infiltrative disorders of skin and subcutaneous tissue
0.000 0.300 0.700
L98.5 Mucinosis of skin
0.000 0.300 0.700
L98.3 Eosinophilic cellulitis [Wells]
0.000 0.300 0.700
L98.1 Factitial dermatitis
0.000 0.300 0.700
N44 Torsion of testis
0.698 0.302 0.000
G35 Multiple sclerosis
0.000 0.303 0.697
H55 Nystagmus and other irregular eye movements
0.000 0.303 0.697
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.303 0.696
E32 Diseases of thymus
0.000 0.303 0.696
E31 Polyglandular dysfunction
0.000 0.303 0.696
E30 Disorders of puberty, not elsewhere classified
0.000 0.303 0.696
F32.2 Severe depressive episode without psychotic symptoms
0.000 0.305 0.695
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.000 0.305 0.695
L23 Allergic contact dermatitis
0.000 0.310 0.690
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.311 0.689
H02.2 Lagophthalmos
0.000 0.311 0.689
E27.5 Adrenomedullary hyperfunction
0.000 0.313 0.687
E27.0 Other adrenocortical overactivity
0.000 0.313 0.687
E27.9 Disorder of adrenal gland, unspecified
0.000 0.314 0.686
E11.7 With multiple complications
0.000 0.315 0.685
F20 Schizophrenia
0.000 0.317 0.683
M06.4 Inflammatory polyarthropathy
0.000 0.317 0.683
L02 Cutaneous abscess, furuncle and carbuncle
0.000 0.317 0.683
E11.0 With coma
0.000 0.318 0.682
D51 Vitamin B12 deficiency anaemia
0.000 0.319 0.681
A63.0 Anogenital (venereal) warts
0.000 0.319 0.681
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.319 0.681
L58 Radiodermatitis
0.000 0.319 0.681
L55 Sunburn
0.000 0.319 0.681
E16 Other disorders of pancreatic internal secretion
0.000 0.320 0.680
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.320 0.679
C44 Other malignant neoplasms of skin
0.000 0.321 0.679
E11.8 With unspecified complications
0.000 0.321 0.678
M65-M68 Disorders of synovium and tendon
0.000 0.323 0.677
M21.0 Valgus deformity, not elsewhere classified
0.000 0.323 0.677
J21 Acute bronchiolitis
0.000 0.324 0.676
C44.3 Skin of other and unspecified parts of face
0.000 0.325 0.675
M62.80 Other specified disorders of muscle (Multiple sites)
0.000 0.326 0.674
D52.9 Folate deficiency anaemia, unspecified
0.000 0.326 0.674
E26 Hyperaldosteronism
0.000 0.327 0.673
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.327 0.673
L93.0 Discoid lupus erythematosus
0.000 0.329 0.670
E03.8 Other specified hypothyroidism
0.000 0.330 0.670
J84.8 Other specified interstitial pulmonary diseases
0.000 0.331 0.669
M34.8 Other forms of systemic sclerosis
0.000 0.331 0.668
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.331 0.668
M34.0 Progressive systemic sclerosis
0.000 0.331 0.668
E23 Hypofunction and other disorders of pituitary gland
0.000 0.333 0.667
C44.7 Skin of lower limb, including hip
0.000 0.335 0.665
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.336 0.664
L30.5 Pityriasis alba
0.000 0.337 0.663
L30.4 Erythema intertrigo
0.000 0.337 0.663
L30.2 Cutaneous autosensitisation
0.000 0.337 0.663
L30.1 Dyshidrosis [pompholyx]
0.000 0.337 0.663
L30.0 Nummular dermatitis
0.000 0.337 0.663
M00-M03 Infectious arthropathies
0.000 0.338 0.662
E20.9 Hypoparathyroidism, unspecified
0.000 0.341 0.659
D67 Hereditary factor IX deficiency
0.000 0.341 0.659
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.341 0.659
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.342 0.658
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.342 0.658
L57.5 Actinic granuloma
0.000 0.342 0.658
L57.3 Poikiloderma of Civatte
0.000 0.342 0.658
L57.2 Cutis rhomboidalis nuchae
0.000 0.342 0.658
L57.1 Actinic reticuloid
0.000 0.342 0.658
Chapter VI Diseases of the nervous system
0.000 0.342 0.658
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.344 0.656
N48.3 Priapism
0.655 0.345 0.000
F32.1 Moderate depressive episode
0.000 0.345 0.655
M30 Polyarteritis nodosa and related conditions
0.000 0.346 0.654
L57.4 Cutis laxa senilis
0.000 0.346 0.654
L81.8 Other specified disorders of pigmentation
0.000 0.347 0.653
L28 Lichen simplex chronicus and prurigo
0.000 0.348 0.652
E88 Other metabolic disorders
0.000 0.350 0.650
E06.9 Thyroiditis, unspecified
0.000 0.350 0.650
L81.7 Pigmented purpuric dermatosis
0.000 0.350 0.650
L81.6 Other disorders of diminished melanin formation
0.000 0.350 0.650
L81.5 Leukoderma, not elsewhere classified
0.000 0.350 0.650
L81.3 Cafe au lait spots
0.000 0.350 0.650
L81.2 Freckles
0.000 0.350 0.650
L81.1 Chloasma
0.000 0.350 0.650
L81.0 Postinflammatory hyperpigmentation
0.000 0.350 0.650
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.350 0.649
L94.0 Localised scleroderma [morphea]
0.000 0.351 0.649
J01 Acute sinusitis
0.000 0.351 0.648
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.352 0.648
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.352 0.648
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.352 0.648
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.352 0.648
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.352 0.648
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.352 0.648
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.352 0.648
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.352 0.648
E73 Lactose intolerance
0.000 0.352 0.648
E06.5 Other chronic thyroiditis
0.000 0.352 0.647
E06.4 Drug-induced thyroiditis
0.000 0.352 0.647
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.352 0.647
E06.1 Subacute thyroiditis
0.000 0.352 0.647
E06.0 Acute thyroiditis
0.000 0.352 0.647
J98.4 Other disorders of lung
0.000 0.353 0.647
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.353 0.647
H02.5 Other disorders affecting eyelid function
0.000 0.354 0.646
M14 Arthropathies in other diseases classified elsewhere
0.000 0.355 0.644
B37.9 Candidiasis, unspecified
0.000 0.356 0.644
L29.9 Pruritus, unspecified
0.000 0.357 0.643
D68.4 Acquired coagulation factor deficiency
0.000 0.358 0.642
D68.1 Hereditary factor XI deficiency
0.000 0.358 0.642
H16 Keratitis
0.000 0.358 0.642
J84.0 Alveolar and parietoalveolar conditions
0.000 0.359 0.640
L08 Other local infections of skin and subcutaneous tissue
0.000 0.360 0.640
B25-B34 Other viral diseases
0.000 0.361 0.639
H53.0 Amblyopia ex anopsia
0.000 0.361 0.639
H05.9 Disorder of orbit, unspecified
0.000 0.361 0.638
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.000 0.361 0.638
H05.4 Enophthalmos
0.000 0.361 0.638
H05.3 Deformity of orbit
0.000 0.361 0.638
H05.1 Chronic inflammatory disorders of orbit
0.000 0.361 0.638
F80-F89 Disorders of psychological development
0.000 0.362 0.638
D53 Other nutritional anaemias
0.000 0.362 0.638
M11 Other crystal arthropathies
0.000 0.364 0.636
F31.0 Bipolar affective disorder, current episode hypomanic
0.000 0.364 0.636
D68.2 Hereditary deficiency of other clotting factors
0.000 0.364 0.636
C44.6 Skin of upper limb, including shoulder
0.000 0.365 0.635
N48.1 Balanoposthitis
0.635 0.365 0.000
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.000 0.365 0.635
J04 Acute laryngitis and tracheitis
0.000 0.365 0.635
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.000 0.366 0.634
F30 Manic episode
0.000 0.366 0.634
F23 Acute and transient psychotic disorders
0.000 0.367 0.633
F22 Persistent delusional disorders
0.000 0.367 0.633
F34 Persistent mood [affective] disorders
0.000 0.367 0.633
E16.2 Hypoglycaemia, unspecified
0.000 0.370 0.630
F31.9 Bipolar affective disorder, unspecified
0.000 0.370 0.630
H05.8 Other disorders of orbit
0.000 0.370 0.630
L94.2 Calcinosis cutis
0.000 0.370 0.630
J20.9 Acute bronchitis, unspecified
0.000 0.370 0.630
H57 Other disorders of eye and adnexa
0.000 0.371 0.629
J98.9 Respiratory disorder, unspecified
0.000 0.372 0.628
M33 Dermatopolymyositis
0.000 0.374 0.626
E28.9 Ovarian dysfunction, unspecified
0.000 0.375 0.625
E28.8 Other ovarian dysfunction
0.000 0.375 0.625
E28.1 Androgen excess
0.000 0.375 0.625
E28.0 Oestrogen excess
0.000 0.375 0.625
N51 Disorders of male genital organs in diseases classified elsewhere
0.625 0.375 0.000
M24 Other specific joint derangements
0.000 0.375 0.625
H35 Other retinal disorders
0.000 0.375 0.625
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.376 0.624
L27.9 Dermatitis due to unspecified substance taken internally
0.000 0.376 0.623
L27.8 Dermatitis due to other substances taken internally
0.000 0.376 0.623
L27.2 Dermatitis due to ingested food
0.000 0.376 0.623
L85.8 Other specified epidermal thickening
0.000 0.377 0.623
D69 Purpura and other haemorrhagic conditions
0.000 0.378 0.622
M63 Disorders of muscle in diseases classified elsewhere
0.000 0.378 0.622
M61 Calcification and ossification of muscle
0.000 0.378 0.622
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.378 0.622
E86 Volume depletion
0.000 0.378 0.622
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.000 0.379 0.621
E04.0 Non-toxic diffuse goitre
0.000 0.380 0.620
L10-L14 Bullous disorders
0.000 0.380 0.620
E53 Deficiency of other B group vitamins
0.000 0.380 0.620
J98.0 Diseases of bronchus, not elsewhere classified
0.000 0.381 0.618
L29.3 Anogenital pruritus, unspecified
0.000 0.385 0.615
L29.1 Pruritus scroti
0.000 0.385 0.615
E65-E68 Obesity and other hyperalimentation
0.000 0.385 0.615
M31.9 Necrotising vasculopathy, unspecified
0.000 0.386 0.614
M31.8 Other specified necrotising vasculopathies
0.000 0.386 0.614
M31.7 Microscopic polyangiitis
0.000 0.386 0.614
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.386 0.614
M31.2 Lethal midline granuloma
0.000 0.386 0.614
M31.1 Thrombotic microangiopathy
0.000 0.386 0.614
M31.0 Hypersensitivity angiitis
0.000 0.386 0.614
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.386 0.613
D55-D59 Haemolytic anaemias
0.000 0.387 0.613
N46 Male infertility
0.613 0.387 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.388 0.611
C44.1 Skin of eyelid, including canthus
0.000 0.389 0.611
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.390 0.610
B85-B89 Pediculosis, acariasis and other infestations
0.000 0.391 0.609
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.000 0.391 0.609
A75-A79 Rickettsioses
0.000 0.391 0.609
A70-A74 Other diseases caused by chlamydiae
0.000 0.391 0.609
A20-A28 Certain zoonotic bacterial diseases
0.000 0.391 0.609
J96 Respiratory failure, not elsewhere classified
0.000 0.391 0.609
E84 Cystic fibrosis
0.000 0.391 0.608
E79 Disorders of purine and pyrimidine metabolism
0.000 0.391 0.608
E77 Disorders of glycoprotein metabolism
0.000 0.391 0.608
E76 Disorders of glycosaminoglycan metabolism
0.000 0.391 0.608
E72 Other disorders of amino-acid metabolism
0.000 0.391 0.608
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.391 0.608
E70 Disorders of aromatic amino-acid metabolism
0.000 0.391 0.608
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.391 0.608
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.000 0.393 0.607
L29.8 Other pruritus
0.000 0.393 0.607
E25 Adrenogenital disorders
0.000 0.394 0.606
F00-F09 Organic, including symptomatic, mental disorders
0.000 0.394 0.606
C44.0 Skin of lip
0.000 0.394 0.606
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.395 0.605
M06.38 Rheumatoid nodule (Other)
0.000 0.395 0.605
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.395 0.605
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.395 0.605
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.395 0.605
M06.33 Rheumatoid nodule (Forearm)
0.000 0.395 0.605
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.395 0.605
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.395 0.605
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.395 0.605
N48.2 Other inflammatory disorders of penis
0.605 0.395 0.000
J95.0 Tracheostomy malfunction
0.000 0.395 0.605
D61.8 Other specified aplastic anaemias
0.000 0.397 0.603
D61.3 Idiopathic aplastic anaemia
0.000 0.397 0.603
D61.2 Aplastic anaemia due to other external agents
0.000 0.397 0.603
D61.1 Drug-induced aplastic anaemia
0.000 0.397 0.603
D61.0 Constitutional aplastic anaemia
0.000 0.397 0.603
E29.1 Testicular hypofunction
0.000 0.398 0.602
N50 Other disorders of male genital organs
0.601 0.399 0.000
H53.2 Diplopia
0.000 0.399 0.601
F39 Unspecified mood [affective] disorder
0.000 0.400 0.600
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.400 0.600
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.400 0.600
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.400 0.600
M62.88 Other specified disorders of muscle (Other)
0.000 0.401 0.599
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.000 0.402 0.598
N41.0 Acute prostatitis
0.598 0.402 0.000
D50.1 Sideropenic dysphagia
0.000 0.402 0.598
F70-F79 Mental retardation
0.000 0.403 0.596
L84 Corns and callosities
0.000 0.404 0.596
L98.2 Febrile neutrophilic dermatosis [Sweet]
0.000 0.404 0.596
H04.1 Other disorders of lachrymal gland
0.000 0.405 0.595
B48 Other mycoses, not elsewhere classified
0.000 0.405 0.595
B47 Mycetoma
0.000 0.405 0.595
B46 Zygomycosis
0.000 0.405 0.595
B45 Cryptococcosis
0.000 0.405 0.595
B43 Chromomycosis and phaeomycotic abscess
0.000 0.405 0.595
B42 Sporotrichosis
0.000 0.405 0.595
B41 Paracoccidioidomycosis
0.000 0.405 0.595
B40 Blastomycosis
0.000 0.405 0.595
B39 Histoplasmosis
0.000 0.405 0.595
B38 Coccidioidomycosis
0.000 0.405 0.595
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.405 0.595

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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