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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2894249
log Bayes Factor = 216.976
Chromosome 6   position 32,325,835  (GRCh37) Explore rs2894249 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
J33 Nasal polyp
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
J33.0 Polyp of nasal cavity
0.000 0.001 0.999
L40-L45 Papulosquamous disorders
0.000 0.001 0.999
E70-E90 Metabolic disorders
0.000 0.001 0.999
J33.9 Nasal polyp, unspecified
0.000 0.001 0.999
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.002 0.998
E11.3 With ophthalmic complications
0.000 0.002 0.998
M07 Psoriatic and enteropathic arthropathies
0.000 0.002 0.998
H36 Retinal disorders in diseases classified elsewhere
0.000 0.002 0.998
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.003 0.997
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
M07.3 Other psoriatic arthropathies
0.000 0.003 0.997
E14.3 With ophthalmic complications
0.000 0.003 0.997
H30-H36 Disorders of choroid and retina
0.000 0.003 0.997
G35-G37 Demyelinating diseases of the central nervous system
0.996 0.004 0.000
G37 Other demyelinating diseases of central nervous system
0.995 0.005 0.000
M35 Other systemic involvement of connective tissue
0.000 0.005 0.995
G37.9 Demyelinating disease of central nervous system, unspecified
0.994 0.006 0.000
# Top node
0.000 0.007 0.993
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.007 0.993
E10.5 With peripheral circulatory complications
0.000 0.007 0.993
J33.8 Other polyp of sinus
0.000 0.007 0.993
I10 Essential (primary) hypertension
0.000 0.007 0.993
I10-I15 Hypertensive diseases
0.000 0.008 0.992
E11.1 With ketoacidosis
0.000 0.009 0.991
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.010 0.990
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.010 0.990
Chapter VII Diseases of the eye and adnexa
0.000 0.010 0.990
M20-M25 Other joint disorders
0.000 0.012 0.988
Chapter IX Diseases of the circulatory system
0.000 0.014 0.986
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.016 0.984
L43 Lichen planus
0.000 0.016 0.984
E10.2 With renal complications
0.000 0.025 0.975
I22 Subsequent myocardial infarction
0.000 0.026 0.974
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.027 0.973
I20-I25 Ischaemic heart diseases
0.000 0.027 0.973
E06 Thyroiditis
0.000 0.030 0.970
L43.9 Lichen planus, unspecified
0.000 0.038 0.962
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.040 0.960
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.041 0.959
I12 Hypertensive renal disease
0.000 0.046 0.954
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.046 0.954
E10.8 With unspecified complications
0.000 0.046 0.954
E06.3 Autoimmune thyroiditis
0.000 0.048 0.952
M65-M68 Disorders of synovium and tendon
0.000 0.051 0.949
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.054 0.946
M34 Systemic sclerosis
0.000 0.055 0.945
H40-H42 Glaucoma
0.000 0.056 0.944
E10.0 With coma
0.000 0.058 0.942
M06.3 Rheumatoid nodule
0.000 0.060 0.940
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.062 0.938
H34 Retinal vascular occlusions
0.000 0.062 0.938
I12.9 Hypertensive renal disease without renal failure
0.000 0.062 0.938
M65 Synovitis and tenosynovitis
0.000 0.066 0.934
M06.0 Seronegative rheumatoid arthritis
0.000 0.068 0.932
M45-M49 Spondylopathies
0.000 0.089 0.911
M65.9 Synovitis and tenosynovitis, unspecified
0.000 0.089 0.911
H40 Glaucoma
0.000 0.089 0.911
E78.2 Mixed hyperlipidaemia
0.000 0.090 0.910
M45 Ankylosing spondylitis
0.000 0.091 0.909
H40.9 Glaucoma, unspecified
0.000 0.092 0.908
M06.4 Inflammatory polyarthropathy
0.000 0.093 0.907
E07 Other disorders of thyroid
0.000 0.093 0.907
H35 Other retinal disorders
0.000 0.100 0.900
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.102 0.898
E78.1 Pure hyperglyceridaemia
0.000 0.107 0.893
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.108 0.892
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.109 0.891
E88 Other metabolic disorders
0.000 0.111 0.889
E11.2 With renal complications
0.000 0.112 0.888
E11.5 With peripheral circulatory complications
0.000 0.119 0.881
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.127 0.873
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.136 0.864
G37.8 Other specified demyelinating diseases of central nervous system
0.860 0.140 0.000
H35.4 Peripheral retinal degeneration
0.000 0.140 0.859
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.142 0.858
L43.8 Other lichen planus
0.000 0.144 0.855
M34.1 CR(E)ST syndrome
0.000 0.145 0.855
M35.7 Hypermobility syndrome
0.000 0.145 0.855
L40.8 Other psoriasis
0.000 0.145 0.855
M35.1 Other overlap syndromes
0.000 0.146 0.854
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.148 0.852
H35.8 Other specified retinal disorders
0.000 0.149 0.851
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.152 0.847
M34.9 Systemic sclerosis, unspecified
0.000 0.155 0.845
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.000 0.164 0.836
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.164 0.836
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.165 0.835
M06.34 Rheumatoid nodule (Hand)
0.000 0.167 0.833
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.171 0.829
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.172 0.828
E07.9 Disorder of thyroid, unspecified
0.000 0.176 0.824
H34.8 Other retinal vascular occlusions
0.000 0.179 0.821
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.180 0.820
E10.6 With other specified complications
0.000 0.183 0.817
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.185 0.815
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.190 0.810
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.193 0.807
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.197 0.803
H34.2 Other retinal artery occlusions
0.000 0.197 0.803
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.000 0.199 0.801
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.201 0.799
E11.8 With unspecified complications
0.000 0.202 0.798
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)
0.000 0.203 0.797
I15 Secondary hypertension
0.000 0.204 0.796
E14.4 With neurological complications
0.000 0.209 0.791
E03.8 Other specified hypothyroidism
0.000 0.210 0.789
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.000 0.214 0.786
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.215 0.785
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.217 0.783
E83 Disorders of mineral metabolism
0.371 0.220 0.409
M30 Polyarteritis nodosa and related conditions
0.000 0.221 0.779
I22.8 Subsequent myocardial infarction of other sites
0.000 0.225 0.775
E74 Other disorders of carbohydrate metabolism
0.000 0.226 0.774
M35.2 Behcet's disease
0.000 0.238 0.762
H43-H45 Disorders of vitreous body and globe
0.000 0.238 0.762
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.242 0.758
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.244 0.756
E89.0 Postprocedural hypothyroidism
0.000 0.245 0.755
E14.5 With peripheral circulatory complications
0.000 0.247 0.753
L57.0 Actinic keratosis
0.000 0.248 0.752
H35.6 Retinal haemorrhage
0.000 0.252 0.748
M31 Other necrotising vasculopathies
0.000 0.257 0.743
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.000 0.262 0.738
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.263 0.737
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.266 0.734
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.733 0.267 0.000
H40.4 Glaucoma secondary to eye inflammation
0.000 0.267 0.733
L40.3 Pustulosis palmaris et plantaris
0.000 0.268 0.732
E14.2 Withrenal complications
0.000 0.269 0.731
M65.1 Other infective (teno)synovitis
0.000 0.271 0.729
G36 Other acute disseminated demyelination
0.729 0.271 0.000
H35.7 Separation of retinal layers
0.000 0.271 0.729
M14 Arthropathies in other diseases classified elsewhere
0.000 0.276 0.724
D64.9 Anaemia, unspecified
0.000 0.280 0.720
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.281 0.719
H30 Chorioretinal inflammation
0.000 0.281 0.719
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.6 With other specified complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
J33.1 Polypoid sinus degeneration
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.284 0.716
L41 Parapsoriasis
0.000 0.284 0.716
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.284 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.284 0.716
E76 Disorders of glycosaminoglycan metabolism
0.000 0.284 0.716
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.284 0.716
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.284 0.716
H34.9 Retinal vascular occlusion, unspecified
0.000 0.284 0.716
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.284 0.716
M07.5 Arthropathy in ulcerative colitis
0.000 0.284 0.715
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.284 0.715
M07.2 Psoriatic spondylitis
0.000 0.284 0.715
M07.1 Arthritis mutilans
0.000 0.284 0.715
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.284 0.715
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.715
M07.38 Other psoriatic arthropathies (Other)
0.000 0.285 0.715
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.285 0.715
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.285 0.715
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.285 0.715
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.285 0.715
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.285 0.715
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.285 0.714
E40-E46 Malnutrition
0.000 0.286 0.714
H34.1 Central retinal artery occlusion
0.000 0.286 0.714
G37.5 Concentric sclerosis [Balo]
0.714 0.286 0.000
G37.4 Subacute necrotising myelitis
0.714 0.286 0.000
G37.2 Central pontine myelinolysis
0.714 0.286 0.000
G37.1 Central demyelination of corpus callosum
0.714 0.286 0.000
G37.0 Diffuse sclerosis
0.714 0.286 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.287 0.713
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.287 0.713
M35.5 Multifocal fibrosclerosis
0.000 0.287 0.713
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.287 0.713
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.288 0.712
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.288 0.712
I13 Hypertensive heart and renal disease
0.000 0.289 0.711
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.289 0.711
D64 Other anaemias
0.000 0.290 0.710
E88.2 Lipomatosis, not elsewhere classified
0.000 0.291 0.709
L40.0 Psoriasis vulgaris
0.000 0.291 0.709
E88.8 Other specified metabolic disorders
0.000 0.291 0.709
D60-D64 Aplastic and other anaemias
0.000 0.291 0.709
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.291 0.708
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.293 0.707
L43.3 Subacute (active) lichen planus
0.000 0.294 0.706
L43.2 Lichenoid drug reaction
0.000 0.294 0.706
L43.1 Bullous lichen planus
0.000 0.294 0.706
L43.0 Hypertrophic lichen planus
0.000 0.294 0.706
Chapter VIII Diseases of the ear and mastoid process
0.000 0.294 0.706
I11 Hypertensive heart disease
0.000 0.299 0.701
E70 Disorders of aromatic amino-acid metabolism
0.000 0.299 0.701
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.299 0.701
E07.8 Other specified disorders of thyroid
0.000 0.301 0.699
E11.6 With other specified complications
0.000 0.303 0.697
H40.5 Glaucoma secondary to other eye disorders
0.000 0.303 0.697
E06.5 Other chronic thyroiditis
0.000 0.304 0.696
E06.4 Drug-induced thyroiditis
0.000 0.304 0.696
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.304 0.696
E06.1 Subacute thyroiditis
0.000 0.304 0.696
E06.0 Acute thyroiditis
0.000 0.304 0.696
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)
0.000 0.305 0.695
M91-M94 Chondropathies
0.000 0.306 0.694
H43 Disorders of vitreous body
0.000 0.307 0.693
M34.8 Other forms of systemic sclerosis
0.000 0.307 0.693
E79 Disorders of purine and pyrimidine metabolism
0.000 0.307 0.692
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.312 0.688
E16.1 Other hypoglycaemia
0.000 0.318 0.682
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.320 0.680
E78.4 Other hyperlipidaemia
0.000 0.322 0.678
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.323 0.677
M34.0 Progressive systemic sclerosis
0.000 0.323 0.677
H42 Glaucoma in diseases classified elsewhere
0.000 0.323 0.677
M12 Other specific arthropathies
0.000 0.323 0.676
H33 Retinal detachments and breaks
0.000 0.326 0.674
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.326 0.674
M06.38 Rheumatoid nodule (Other)
0.000 0.326 0.674
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.326 0.674
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.326 0.674
M06.33 Rheumatoid nodule (Forearm)
0.000 0.326 0.674
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.326 0.674
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.326 0.674
H34.0 Transient retinal artery occlusion
0.000 0.327 0.672
H60-H62 Diseases of external ear
0.000 0.328 0.672
M86-M90 Other osteopathies
0.000 0.328 0.672
M65.2 Calcific tendinitis
0.000 0.330 0.670
M65.0 Abscess of tendon sheath
0.000 0.330 0.670
E13 Other specified diabetes mellitus
0.000 0.331 0.669
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.331 0.668
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.331 0.668
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.331 0.668
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.331 0.668
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.331 0.668
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.331 0.668
M07.6 Other enteropathic arthropathies
0.000 0.331 0.668
E84 Cystic fibrosis
0.000 0.333 0.666
M49 Spondylopathies in diseases classified elsewhere
0.000 0.339 0.661
H35.2 Other proliferative retinopathy
0.000 0.340 0.660
E72 Other disorders of amino-acid metabolism
0.000 0.340 0.660
E11.4 With neurological complications
0.000 0.343 0.657
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.344 0.656
L10-L14 Bullous disorders
0.000 0.346 0.654
M65.98 Synovitis and tenosynovitis, unspecified (Other)
0.000 0.347 0.653
H40.6 Glaucoma secondary to drugs
0.000 0.347 0.653
H40.3 Glaucoma secondary to eye trauma
0.000 0.347 0.653
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.348 0.652
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.348 0.652
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.348 0.652
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.348 0.652
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.348 0.652
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.348 0.652
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.349 0.651
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.349 0.651
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.349 0.651
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.349 0.651
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.349 0.651
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.349 0.651
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.349 0.651
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.349 0.651
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)
0.000 0.350 0.650
E07.1 Dyshormogenetic goitre
0.000 0.350 0.650
E07.0 Hypersecretion of calcitonin
0.000 0.350 0.650
E06.9 Thyroiditis, unspecified
0.000 0.351 0.649
H35.1 Retinopathy of prematurity
0.000 0.355 0.645
M66 Spontaneous rupture of synovium and tendon
0.000 0.355 0.644
M32 Systemic lupus erythematosus
0.000 0.356 0.644
E88.3 Tumour lysis syndrome
0.000 0.359 0.641
I21 Acute myocardial infarction
0.000 0.360 0.640
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec
0.000 0.360 0.640
M65.48 Radial styloid tenosynovitis [de Quervain]-Other
0.000 0.360 0.640
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot
0.000 0.360 0.640
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg
0.000 0.360 0.640
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh
0.000 0.360 0.640
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm
0.000 0.360 0.640
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region
0.000 0.360 0.640
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)
0.000 0.360 0.640
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.362 0.638
E88.9 Metabolic disorder, unspecified
0.000 0.362 0.638
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.362 0.638
M11 Other crystal arthropathies
0.000 0.375 0.625
I15.9 Seconday hypertension, unspecified
0.000 0.376 0.624
I15.1 Hypertension secondary to other renal disorders
0.000 0.377 0.623
M31.6 Other giant cell arteritis
0.000 0.381 0.619
M86 Osteomyelitis
0.000 0.382 0.618
L42 Pityriasis rosea
0.000 0.383 0.617
H61 Other disorders of external ear
0.000 0.383 0.617
E89.4 Postprocedural ovarian failure
0.000 0.385 0.615
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.387 0.613
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.387 0.613
H43.3 Other vitreous opacities
0.000 0.388 0.612
E05.8 Other thyrotoxicosis
0.000 0.390 0.610
L55 Sunburn
0.000 0.392 0.608
H33.3 Retinal breaks without detachment
0.000 0.396 0.604
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.396 0.604
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.000 0.399 0.601
H40.1 Primary open-angle glaucoma
0.000 0.399 0.601
E73 Lactose intolerance
0.000 0.400 0.600
M35.0 Sicca syndrome [Sjogren]
0.000 0.401 0.599
I23 Certain current complications following acute myocardial infarction
0.000 0.403 0.597
E20-E35 Disorders of other endocrine glands
0.000 0.406 0.594
M33 Dermatopolymyositis
0.000 0.407 0.593
M30.0 Polyarteritis nodosa
0.000 0.408 0.592
H43.9 Disorder of vitreous body, unspecified
0.000 0.409 0.591
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.409 0.591
H60 Otitis externa
0.000 0.411 0.589
I21.9 Acute myocardial infarction, unspecified
0.000 0.411 0.589
H40.0 Glaucoma suspect
0.000 0.411 0.589
M60-M63 Disorders of muscles
0.000 0.411 0.588
M86.9 Osteomyelitis, unspecified
0.000 0.412 0.588
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.412 0.588
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.412 0.588
E89.5 Postprocedural testicular hypofunction
0.000 0.412 0.588
E89.1 Postprocedural hypoinsulinaemia
0.000 0.412 0.588
M15-M19 Arthrosis
0.000 0.414 0.586
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.416 0.584
I24 Other acute ischaemic heart diseases
0.000 0.416 0.584
M14.6 Neuropathic arthropathy
0.000 0.416 0.584
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.417 0.582
M65.14 Other infective (teno)synovitis (Hand)
0.000 0.418 0.582
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.418 0.582
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.421 0.579
E65-E68 Obesity and other hyperalimentation
0.000 0.422 0.578
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.000 0.426 0.574
M10 Gout
0.000 0.428 0.572
I15.8 Other secondary hypertension
0.000 0.429 0.571
I15.2 Hypertension secondary to endocrine disorders
0.000 0.429 0.571
M80-M85 Disorders of bone density and structure
0.000 0.430 0.570
E11.0 With coma
0.000 0.431 0.569
L20-L30 Dermatitis and eczema
0.000 0.433 0.567
E78.8 Other disorders of lipoprotein metabolism
0.000 0.437 0.563
L57.5 Actinic granuloma
0.000 0.437 0.563
L57.3 Poikiloderma of Civatte
0.000 0.437 0.563
L57.2 Cutis rhomboidalis nuchae
0.000 0.437 0.563
L57.1 Actinic reticuloid
0.000 0.437 0.563
E03.1 Congenital hypothyroidism without goitre
0.000 0.438 0.561
M00-M03 Infectious arthropathies
0.000 0.440 0.560
E89.3 Postprocedural hypopituitarism
0.000 0.440 0.560
E83.8 Other disorders of mineral metabolism
0.266 0.441 0.293
E83.2 Disorders of zinc metabolism
0.266 0.441 0.293
E83.0 Disorders of copper metabolism
0.266 0.441 0.293
D62 Acute posthaemorrhagic anaemia
0.000 0.441 0.559
M30.8 Other conditions related to polyarteritis nodosa
0.000 0.442 0.558
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.000 0.442 0.558
M30.2 Juvenile polyarteritis
0.000 0.442 0.558
I15.0 Renovascular hypertension
0.000 0.443 0.557
M31.3 Wegener's granulomatosis
0.000 0.443 0.557
H61.0 Perichondritis of external ear
0.000 0.443 0.557
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.445 0.555
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.445 0.555
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.445 0.555
E74.2 Disorders of galactose metabolism
0.000 0.445 0.555
E74.1 Disorders of fructose metabolism
0.000 0.445 0.555
E74.0 Glycogen storage disease
0.000 0.445 0.555
L58 Radiodermatitis
0.000 0.445 0.555
I70 Atherosclerosis
0.000 0.449 0.551
E83.9 Disorder of mineral metabolism, unspecified
0.288 0.452 0.260
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.453 0.547
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.453 0.547
L28 Lichen simplex chronicus and prurigo
0.000 0.455 0.545
H61.8 Other specified disorders of external ear
0.000 0.457 0.543
M31.9 Necrotising vasculopathy, unspecified
0.000 0.458 0.542
H33.4 Traction detachment of retina
0.000 0.460 0.540
M31.1 Thrombotic microangiopathy
0.000 0.460 0.540
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.461 0.539
M18 Arthrosis of first carpometacarpal joint
0.000 0.461 0.539
G36.0 Neuromyelitis optica [Devic]
0.537 0.463 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.463 0.537
M31.8 Other specified necrotising vasculopathies
0.000 0.467 0.533
M31.7 Microscopic polyangiitis
0.000 0.467 0.533
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.467 0.533
M31.2 Lethal midline granuloma
0.000 0.467 0.533
E89.2 Postprocedural hypoparathyroidism
0.000 0.470 0.529
H61.1 Non-infective disorders of pinna
0.000 0.472 0.528
M94 Other disorders of cartilage
0.000 0.474 0.526
E28 Ovarian dysfunction
0.000 0.474 0.526
I00 Rheumatic fever without mention of heart involvement
0.000 0.477 0.523
H43.2 Crystalline deposits in vitreous body
0.000 0.477 0.523
M65.19 Other infective (teno)synovitis (Site unspecified)
0.000 0.477 0.523
M65.18 Other infective (teno)synovitis (Other)
0.000 0.477 0.523
M65.17 Other infective (teno)synovitis (Ankle and foot)
0.000 0.477 0.523
M65.16 Other infective (teno)synovitis (Lower leg)
0.000 0.477 0.523
M65.15 Other infective (teno)synovitis (Pelvic region and thigh)
0.000 0.477 0.523
M65.13 Other infective (teno)synovitis (Forearm)
0.000 0.477 0.523
M65.12 Other infective (teno)synovitis (Upper arm)
0.000 0.477 0.523
M65.11 Other infective (teno)synovitis (Shoulder region)
0.000 0.477 0.523
M65.10 Other infective (teno)synovitis (Multiple sites)
0.000 0.477 0.523
I12.0 Hypertensive renal disease with renal failure
0.000 0.477 0.523
G36.9 Acute disseminated demyelination, unspecified
0.523 0.477 0.000
G36.8 Other specified acute disseminated demyelination
0.523 0.477 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.523 0.477 0.000
H35.5 Hereditary retinal dystrophy
0.000 0.477 0.522
M92 Other juvenile osteochondrosis
0.000 0.479 0.521
H30.9 Chorioretinal inflammation, unspecified
0.000 0.480 0.520
H46 Optic neuritis
0.000 0.480 0.520
H60.3 Other infective otitis externa
0.000 0.480 0.520
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.480 0.520
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.480 0.519
L28.0 Lichen simplex chronicus
0.000 0.481 0.519
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.481 0.519
M14.4 Arthropathy in amyloidosis
0.000 0.481 0.519
M14.3 Lipoid dermatoarthritis
0.000 0.481 0.519
M14.2 Diabetic arthropathy
0.000 0.481 0.519
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.481 0.519
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.481 0.519
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.481 0.519
M18.1 Other primary arthrosis of first carpometacarpal joint
0.000 0.482 0.518
H30.8 Other chorioretinal inflammations
0.000 0.484 0.515
H30.2 Posterior cyclitis
0.000 0.484 0.515
H30.1 Disseminated chorioretinal inflammation
0.000 0.484 0.515
H30.0 Focal chorioretinal inflammation
0.000 0.484 0.515
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.486 0.514
M06.18 Adult-onset Still's disease (Other)
0.000 0.486 0.514
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.486 0.514
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.486 0.514
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.486 0.514
M06.14 Adult-onset Still's disease (Hand)
0.000 0.486 0.514
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.486 0.514
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.486 0.514
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.486 0.514
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.486 0.514
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.486 0.514
M06.28 Rheumatoid bursitis (Other)
0.000 0.486 0.514

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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