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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3099849
log Bayes Factor = 51.0561
Chromosome 6   position 31,351,415  (GRCh37) Explore rs3099849 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.002 0.998
E14 Unspecified diabetes mellitus
0.000 0.004 0.996
E70-E90 Metabolic disorders
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.006 0.994
E11 Non-insulin-dependent diabetes mellitus
0.000 0.009 0.991
E14.9 Without complications
0.000 0.010 0.990
E10.1 With ketoacidosis
0.000 0.011 0.989
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.021 0.979
K51 Ulcerative colitis
0.975 0.025 0.000
K51.9 Ulcerative colitis, unspecified
0.973 0.027 0.000
E11.9 Without complications
0.000 0.033 0.967
K51.3 Ulcerative (chronic) rectosigmoiditis
0.956 0.044 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.045 0.955
E10.4 With neurological complications
0.000 0.064 0.936
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.072 0.928
E11.1 With ketoacidosis
0.000 0.075 0.925
E16 Other disorders of pancreatic internal secretion
0.000 0.077 0.923
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.077 0.923
K51.4 Pseudopolyposis of colon
0.921 0.079 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.079 0.921
K51.8 Other ulcerative colitis
0.918 0.082 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.101 0.899
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.106 0.894
E16.2 Hypoglycaemia, unspecified
0.000 0.115 0.885
G35-G37 Demyelinating diseases of the central nervous system
0.882 0.118 0.000
E14.3 With ophthalmic complications
0.000 0.124 0.876
E07 Other disorders of thyroid
0.000 0.124 0.876
E11.0 With coma
0.000 0.130 0.870
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.131 0.869
E10.8 With unspecified complications
0.000 0.140 0.860
G37 Other demyelinating diseases of central nervous system
0.850 0.149 0.000
K51.2 Ulcerative (chronic) proctitis
0.848 0.152 0.000
E74 Other disorders of carbohydrate metabolism
0.000 0.154 0.846
E10.2 With renal complications
0.000 0.157 0.843
K51.0 Ulcerative (chronic) enterocolitis
0.840 0.160 0.000
E85 Amyloidosis
0.000 0.162 0.838
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.164 0.836
E78.5 Hyperlipidaemia, unspecified
0.000 0.171 0.829
K51.5 Mucosal proctocolitis
0.824 0.176 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.821 0.179 0.000
E78.1 Pure hyperglyceridaemia
0.000 0.185 0.815
J45.9 Asthma, unspecified
0.000 0.193 0.807
E07.9 Disorder of thyroid, unspecified
0.000 0.198 0.802
E78.2 Mixed hyperlipidaemia
0.000 0.198 0.802
I10 Essential (primary) hypertension
0.000 0.206 0.794
E20-E35 Disorders of other endocrine glands
0.000 0.219 0.781
E16.1 Other hypoglycaemia
0.000 0.228 0.771
E10.0 With coma
0.000 0.233 0.767
E10.6 With other specified complications
0.000 0.237 0.763
E11.2 With renal complications
0.000 0.246 0.754
E14.4 With neurological complications
0.000 0.246 0.754
E10.5 With peripheral circulatory complications
0.000 0.247 0.753
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.257 0.743
E05.8 Other thyrotoxicosis
0.000 0.259 0.741
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.261 0.739
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.269 0.731
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.271 0.729
E14.5 With peripheral circulatory complications
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.284 0.716
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.285 0.715
E14.8 With unspecified complications
0.000 0.285 0.714
E14.7 With multiple complications
0.000 0.285 0.714
E14.6 With other specified complications
0.000 0.285 0.714
E14.2 Withrenal complications
0.000 0.285 0.714
E14.1 With ketoacidosis
0.000 0.285 0.714
E14.0 With coma
0.000 0.285 0.714
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
E11.7 With multiple complications
0.000 0.289 0.711
G37.8 Other specified demyelinating diseases of central nervous system
0.710 0.290 0.000
E11.3 With ophthalmic complications
0.000 0.292 0.708
E78.4 Other hyperlipidaemia
0.000 0.296 0.704
E84 Cystic fibrosis
0.000 0.296 0.704
E79 Disorders of purine and pyrimidine metabolism
0.000 0.296 0.703
E85.9 Amyloidosis, unspecified
0.000 0.299 0.701
E11.5 With peripheral circulatory complications
0.000 0.300 0.700
E06 Thyroiditis
0.000 0.303 0.697
E15 Nondiabetic hypoglycaemic coma
0.000 0.315 0.685
E40-E46 Malnutrition
0.000 0.315 0.684
E28 Ovarian dysfunction
0.000 0.318 0.682
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.324 0.675
E13 Other specified diabetes mellitus
0.000 0.332 0.668
E85.4 Organ-limited amyloidosis
0.000 0.337 0.663
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.338 0.662
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.338 0.662
E16.4 Abnormal secretion of gastrin
0.000 0.338 0.662
E16.3 Increased secretion of glucagon
0.000 0.338 0.662
E11.8 With unspecified complications
0.000 0.340 0.660
E03.8 Other specified hypothyroidism
0.000 0.343 0.656
K51.1 Ulcerative (chronic) ileocolitis
0.656 0.344 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.346 0.654
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.348 0.652
E73 Lactose intolerance
0.000 0.350 0.650
E23 Hypofunction and other disorders of pituitary gland
0.000 0.356 0.644
E11.6 With other specified complications
0.000 0.363 0.637
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.363 0.637
G36 Other acute disseminated demyelination
0.632 0.368 0.000
E28.2 Polycystic ovarian syndrome
0.000 0.370 0.630
E07.1 Dyshormogenetic goitre
0.000 0.372 0.628
E07.0 Hypersecretion of calcitonin
0.000 0.372 0.628
M06 Other rheumatoid arthritis
0.000 0.374 0.626
E24 Cushing's syndrome
0.000 0.387 0.613
E29 Testicular dysfunction
0.000 0.390 0.610
G37.5 Concentric sclerosis [Balo]
0.610 0.390 0.000
G37.4 Subacute necrotising myelitis
0.610 0.390 0.000
G37.2 Central pontine myelinolysis
0.610 0.390 0.000
G37.1 Central demyelination of corpus callosum
0.610 0.390 0.000
G37.0 Diffuse sclerosis
0.610 0.390 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.393 0.607
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.393 0.607
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.393 0.607
E74.2 Disorders of galactose metabolism
0.000 0.393 0.607
E74.1 Disorders of fructose metabolism
0.000 0.393 0.607
E74.0 Glycogen storage disease
0.000 0.393 0.607
E85.8 Other amyloidosis
0.000 0.399 0.601
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.399 0.601
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.399 0.601
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.399 0.601
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.403 0.597
E83 Disorders of mineral metabolism
0.412 0.406 0.182
I10-I15 Hypertensive diseases
0.000 0.416 0.584
M06.3 Rheumatoid nodule
0.000 0.418 0.582
E07.8 Other specified disorders of thyroid
0.000 0.421 0.579
E22 Hyperfunction of pituitary gland
0.000 0.423 0.577
E85.3 Secondary systemic amyloidosis
0.000 0.427 0.573
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.430 0.570
E50-E64 Other nutritional deficiencies
0.000 0.437 0.563
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.438 0.562
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.440 0.560
E32 Diseases of thymus
0.000 0.440 0.560
E31 Polyglandular dysfunction
0.000 0.440 0.560
E30 Disorders of puberty, not elsewhere classified
0.000 0.440 0.560
E25 Adrenogenital disorders
0.000 0.440 0.560
E26 Hyperaldosteronism
0.000 0.448 0.552
E23.7 Disorder of pituitary gland, unspecified
0.000 0.451 0.549
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.538 0.462 0.000
I12 Hypertensive renal disease
0.000 0.474 0.526
M06.34 Rheumatoid nodule (Hand)
0.000 0.476 0.524
E89.3 Postprocedural hypopituitarism
0.000 0.480 0.520
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.512
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.512
E70.3 Albinism
0.000 0.488 0.512
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.512
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.512
E70.0 Classical phenylketonuria
0.000 0.488 0.512
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.512
E71.0 Maple-syrup-urine disease
0.000 0.488 0.512
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.512
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.512
E72.5 Disorders of glycine metabolism
0.000 0.488 0.512
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.512
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.512
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.512
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.512
E72.0 Disorders of amino-acid transport
0.000 0.488 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.512
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.492 0.508
E21.3 Hyperparathyroidism, unspecified
0.000 0.494 0.506
E84.8 Cystic fibrosis with other manifestations
0.000 0.495 0.505
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.495 0.505
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.495 0.505
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.495 0.504
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.495 0.504
E79.1 Lesch-Nyhan syndrome
0.000 0.495 0.504
M45 Ankylosing spondylitis
0.000 0.497 0.503
E06.5 Other chronic thyroiditis
0.000 0.500 0.500
E06.4 Drug-induced thyroiditis
0.000 0.500 0.500
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.500 0.500
E06.1 Subacute thyroiditis
0.000 0.500 0.500
E06.0 Acute thyroiditis
0.000 0.500 0.500
E06.3 Autoimmune thyroiditis
0.000 0.504 0.496
E84.9 Cystic fibrosis, unspecified
0.000 0.505 0.495
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.505 0.494
E24.9 Cushing's syndrome, unspecified
0.000 0.507 0.493
E23.6 Other disorders of pituitary gland
0.000 0.507 0.493
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.509 0.491
E45 Retarded development following protein-energy malnutrition
0.000 0.509 0.491
E43 Unspecified severe protein-energy malnutrition
0.000 0.509 0.491
E42 Marasmic kwashiorkor
0.000 0.509 0.491
E41 Nutritional marasmus
0.000 0.509 0.491
E40 Kwashiorkor
0.000 0.509 0.491
E28.9 Ovarian dysfunction, unspecified
0.000 0.511 0.489
E28.8 Other ovarian dysfunction
0.000 0.511 0.489
E28.1 Androgen excess
0.000 0.511 0.489
E28.0 Oestrogen excess
0.000 0.511 0.489
E29.1 Testicular hypofunction
0.000 0.512 0.488
E75.6 Lipid storage disorder, unspecified
0.000 0.515 0.484
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.515 0.484
E75.3 Sphingolipidosis, unspecified
0.000 0.515 0.484
E75.2 Other sphingolipidosis
0.000 0.515 0.484
E75.1 Other gangliosidosis
0.000 0.515 0.484
E75.0 GM2 gangliosidosis
0.000 0.515 0.484
E06.9 Thyroiditis, unspecified
0.000 0.516 0.484
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.516 0.483
E61 Deficiency of other nutrient elements
0.000 0.517 0.482
I12.9 Hypertensive renal disease without renal failure
0.000 0.518 0.482
E13.8 With unspecified complications
0.000 0.521 0.479
E13.7 With multiple complications
0.000 0.521 0.479
E13.6 With other specified complications
0.000 0.521 0.479
E13.5 With peripheral circulatory complications
0.000 0.521 0.479
E13.4 With neurological complications
0.000 0.521 0.479
E13.3 With ophthalmic complications
0.000 0.521 0.479
E13.2 With renal complications
0.000 0.521 0.479
E13.1 With ketoacidosis
0.000 0.521 0.479
E13.0 With coma
0.000 0.521 0.479
E23.2 Diabetes insipidus
0.000 0.528 0.472
E65-E68 Obesity and other hyperalimentation
0.000 0.528 0.471
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.532 0.468
E34 Other endocrine disorders
0.000 0.532 0.468
E73.8 Other lactose intolerance
0.000 0.534 0.466
E73.1 Secondary lactase deficiency
0.000 0.534 0.466
E73.0 Congenital lactase deficiency
0.000 0.534 0.466
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.538 0.462
E23.1 Drug-induced hypopituitarism
0.000 0.538 0.462
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.539 0.461
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.541 0.459
E46 Unspecified protein-energy malnutrition
0.000 0.542 0.458
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.546 0.454
G36.9 Acute disseminated demyelination, unspecified
0.453 0.547 0.000
G36.8 Other specified acute disseminated demyelination
0.453 0.547 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.453 0.547 0.000
G36.0 Neuromyelitis optica [Devic]
0.453 0.547 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.551 0.449
M06.2 Rheumatoid bursitis
0.000 0.551 0.449
M06.1 Adult-onset Still's disease
0.000 0.551 0.449
E75.5 Other lipid storage disorders
0.000 0.553 0.446
E11.4 With neurological complications
0.000 0.555 0.445
E24.8 Other Cushing's syndrome
0.000 0.560 0.440
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.560 0.440
E24.3 Ectopic ACTH syndrome
0.000 0.560 0.440
E24.2 Drug-induced Cushing's syndrome
0.000 0.560 0.440
E24.1 Nelson's syndrome
0.000 0.560 0.440
E24.0 Pituitary-dependent Cushing's disease
0.000 0.560 0.440
E20 Hypoparathyroidism
0.000 0.560 0.439
E29.9 Testicular dysfunction, unspecified
0.000 0.563 0.437
E29.8 Other testicular dysfunction
0.000 0.563 0.437
E29.0 Testicular hyperfunction
0.000 0.563 0.437
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.564 0.436
I15 Secondary hypertension
0.000 0.565 0.435
E61.1 Iron deficiency
0.000 0.567 0.433
E13.9 Without complications
0.000 0.570 0.430
E22.0 Acromegaly and pituitary gigantism
0.000 0.570 0.430
E89.4 Postprocedural ovarian failure
0.000 0.572 0.428
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.572 0.428
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.572 0.428
E89.5 Postprocedural testicular hypofunction
0.000 0.572 0.428
E89.1 Postprocedural hypoinsulinaemia
0.000 0.572 0.428
E83.9 Disorder of mineral metabolism, unspecified
0.296 0.574 0.130
E83.8 Other disorders of mineral metabolism
0.296 0.574 0.130
E83.2 Disorders of zinc metabolism
0.296 0.574 0.130
E83.0 Disorders of copper metabolism
0.296 0.574 0.130
E28.3 Primary ovarian failure
0.000 0.581 0.419
I13 Hypertensive heart and renal disease
0.000 0.581 0.419
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.582 0.418
M06.38 Rheumatoid nodule (Other)
0.000 0.582 0.418
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.582 0.418
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.582 0.418
M06.33 Rheumatoid nodule (Forearm)
0.000 0.582 0.418
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.582 0.418
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.582 0.418
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.586 0.414
E22.8 Other hyperfunction of pituitary gland
0.000 0.586 0.414
M06.4 Inflammatory polyarthropathy
0.000 0.586 0.414
I11 Hypertensive heart disease
0.000 0.591 0.409
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.591 0.409
E21.4 Other specified disorders of parathyroid gland
0.000 0.591 0.409
E21.2 Other hyperparathyroidism
0.000 0.591 0.409
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.592 0.408
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.596 0.404
E63 Other nutritional deficiencies
0.000 0.596 0.404
E56 Other vitamin deficiencies
0.000 0.596 0.404
E51 Thiamine deficiency
0.000 0.596 0.404
E50 Vitamin A deficiency
0.000 0.596 0.404
E60 Dietary zinc deficiency
0.000 0.596 0.404
E59 Dietary selenium deficiency
0.000 0.596 0.404
E58 Dietary calcium deficiency
0.000 0.596 0.404
E54 Ascorbic acid deficiency
0.000 0.596 0.404
E52 Niacin deficiency [pellagra]
0.000 0.596 0.404
E23.0 Hypopituitarism
0.000 0.597 0.403
E73.9 Lactose intolerance, unspecified
0.000 0.597 0.402
E25.9 Adrenogenital disorder, unspecified
0.000 0.598 0.401
E25.8 Other adrenogenital disorders
0.000 0.598 0.401
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.598 0.401
E30.9 Disorder of puberty, unspecified
0.000 0.598 0.401
E30.8 Other disorders of puberty
0.000 0.598 0.401
E30.1 Precocious puberty
0.000 0.598 0.401
E30.0 Delayed puberty
0.000 0.598 0.401
E31.9 Polyglandular dysfunction, unspecified
0.000 0.598 0.401
E31.8 Other polyglandular dysfunction
0.000 0.598 0.401
E31.1 Polyglandular hyperfunction
0.000 0.598 0.401
E31.0 Autoimmune polyglandular failure
0.000 0.598 0.401
E32.9 Disease of thymus, unspecified
0.000 0.598 0.401
E32.8 Other diseases of thymus
0.000 0.598 0.401
E32.1 Abscess of thymus
0.000 0.598 0.401
E32.0 Persistent hyperplasia of thymus
0.000 0.598 0.401
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.598 0.401
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.598 0.401
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.598 0.401
E26.9 Hyperaldosteronism, unspecified
0.000 0.604 0.396
E26.8 Other hyperaldosteronism
0.000 0.604 0.396
E26.1 Secondary hyperaldosteronism
0.000 0.604 0.396
E83.3 Disorders of phosphorus metabolism
0.315 0.607 0.078
E22.1 Hyperprolactinaemia
0.000 0.611 0.389
E26.0 Primary hyperaldosteronism
0.000 0.611 0.389
I12.0 Hypertensive renal disease with renal failure
0.000 0.613 0.387
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.636 0.364
E80.5 Crigler-Najjar syndrome
0.000 0.636 0.364
E80.3 Defects of catalase and peroxydase
0.000 0.636 0.364
E80.2 Other porphyria
0.000 0.636 0.364
E80.0 Hereditary erythropoietic porphyria
0.000 0.636 0.364
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.637 0.363
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.639 0.360
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.639 0.360
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.639 0.360
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.639 0.360
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.639 0.360
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.639 0.360
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.639 0.360
E80.6 Other disorders of bilirubin metabolism
0.000 0.642 0.358
E44.1 Mild protein-energy malnutrition
0.000 0.648 0.352
E44.0 Moderate protein-energy malnutrition
0.000 0.648 0.352
E80.1 Porphyria cutanea tarda
0.000 0.651 0.349
E61.9 Deficiency of nutrient element, unspecified
0.000 0.654 0.346
E61.8 Deficiency of other specified nutrient elements
0.000 0.654 0.346
E61.7 Deficiency of multiple nutrient elements
0.000 0.654 0.346
E61.6 Vanadium deficiency
0.000 0.654 0.346
E61.5 Molybdenum deficiency
0.000 0.654 0.346
E61.4 Chromium deficiency
0.000 0.654 0.346
E61.3 Manganese deficiency
0.000 0.654 0.346
E61.0 Copper deficiency
0.000 0.654 0.346
E88 Other metabolic disorders
0.001 0.655 0.344
E65 Localised adiposity
0.000 0.660 0.340
E67 Other hyperalimentation
0.000 0.662 0.338
E68 Sequelae of hyperalimentation
0.000 0.662 0.338
E34.5 Androgen resistance syndrome
0.000 0.664 0.335
E34.4 Constitutional tall stature
0.000 0.664 0.335
E34.3 Short stature, not elsewhere classified
0.000 0.664 0.335
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.664 0.335
E34.1 Other hypersecretion of intestinal hormones
0.000 0.664 0.335
I15.1 Hypertension secondary to other renal disorders
0.000 0.671 0.329
E61.2 Magnesium deficiency
0.000 0.678 0.322
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.678 0.322
M06.18 Adult-onset Still's disease (Other)
0.000 0.678 0.322
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.678 0.322
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.678 0.322
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.678 0.322
M06.14 Adult-onset Still's disease (Hand)
0.000 0.678 0.322
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.678 0.322
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.678 0.322
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.678 0.322
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.678 0.322
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.678 0.322
M06.28 Rheumatoid bursitis (Other)
0.000 0.678 0.322
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.678 0.322
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.678 0.322
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.678 0.322
M06.24 Rheumatoid bursitis (Hand)
0.000 0.678 0.322
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.678 0.322
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.678 0.322
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.678 0.322
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.678 0.322
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.678 0.322
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.678 0.322
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.678 0.322
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.678 0.322
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.678 0.322
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.678 0.322
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.678 0.322
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.678 0.322
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.678 0.322
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.678 0.322
E34.8 Other specified endocrine disorders
0.000 0.683 0.317
M06.0 Seronegative rheumatoid arthritis
0.000 0.683 0.317
E34.0 Carcinoid syndrome
0.000 0.685 0.315
E20.8 Other hypoparathyroidism
0.000 0.685 0.315
E20.1 Pseudohypoparathyroidism
0.000 0.685 0.315
E20.0 Idiopathic hypoparathyroidism
0.000 0.685 0.315
I15.9 Seconday hypertension, unspecified
0.000 0.688 0.312
I15.8 Other secondary hypertension
0.000 0.688 0.312
I15.2 Hypertension secondary to endocrine disorders
0.000 0.688 0.312
I15.0 Renovascular hypertension
0.000 0.688 0.312
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.695 0.305
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.699 0.300
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.699 0.300
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.699 0.300
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.699 0.300
E89.2 Postprocedural hypoparathyroidism
0.000 0.703 0.297
E34.9 Endocrine disorder, unspecified
0.000 0.703 0.297
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.703 0.297
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.703 0.297
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.703 0.297
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.703 0.297
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.703 0.297
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.703 0.297
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.703 0.297
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.703 0.297
E83.5 Disorders of calcium metabolism
0.279 0.704 0.017
E27 Other disorders of adrenal gland
0.000 0.705 0.295
E50.9 Vitamin A deficiency, unspecified
0.000 0.710 0.289
E50.8 Other manifestations of vitamin A deficiency
0.000 0.710 0.289
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.710 0.289
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.710 0.289
E50.5 Vitamin A deficiency with night blindness
0.000 0.710 0.289
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.710 0.289
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.710 0.289
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.710 0.289
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.710 0.289
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.710 0.289
E51.9 Thiamine deficiency, unspecified
0.000 0.710 0.289
E51.8 Other manifestations of thiamine deficiency
0.000 0.710 0.289
E51.2 Wernicke's encephalopathy
0.000 0.710 0.289
E51.1 Beriberi
0.000 0.710 0.289
E56.9 Vitamin deficiency, unspecified
0.000 0.710 0.289
E56.8 Deficiency of other vitamins
0.000 0.710 0.289
E56.1 Deficiency of vitamin K
0.000 0.710 0.289
E56.0 Deficiency of vitamin E
0.000 0.710 0.289
E63.9 Nutritional deficiency, unspecified
0.000 0.710 0.289
E63.8 Other specified nutritional deficiencies
0.000 0.710 0.289
E63.1 Imbalance of constituents of food intake
0.000 0.710 0.289
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.710 0.289
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.710 0.289
E64.8 Sequelae of other nutritional deficiencies
0.000 0.710 0.289
E64.3 Sequelae of rickets
0.000 0.710 0.289
E64.2 Sequelae of vitamin C deficiency
0.000 0.710 0.289
E64.1 Sequelae of vitamin A deficiency
0.000 0.710 0.289
E64.0 Sequelae of protein-energy malnutrition
0.000 0.710 0.289
E55 Vitamin D deficiency
0.000 0.711 0.288
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.715 0.285
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.724 0.276
E21.0 Primary hyperparathyroidism
0.000 0.725 0.275
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.730 0.270
K90 Intestinal malabsorption
0.000 0.747 0.253
E27.9 Disorder of adrenal gland, unspecified
0.000 0.748 0.252
E83.4 Disorders of magnesium metabolism
0.111 0.752 0.137
E88.9 Metabolic disorder, unspecified
0.001 0.752 0.247
E67.8 Other specified hyperalimentation
0.000 0.757 0.242
E67.3 Hypervitaminosis D
0.000 0.757 0.242
E67.2 Megavitamin-B6 syndrome
0.000 0.757 0.242

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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