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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs34026679
log Bayes Factor = 10.6117
Chromosome 21   position 27,248,814  (GRCh37) Explore rs34026679 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
1.000 0.000 0.000
Chapter XXI Factors influencing health status and contact with health services
1.000 0.000 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
1.000 0.000 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
1.000 0.000 0.000
Z88.8 Personal history of allergy to other drugs, medicaments and biological substances
0.999 0.001 0.000
M50-M54 Other dorsopathies
0.999 0.001 0.000
Chapter I Certain infectious and parasitic diseases
0.998 0.002 0.000
Z98 Other postsurgical states
0.997 0.003 0.000
A30-A49 Other bacterial diseases
0.997 0.003 0.000
M54 Dorsalgia
0.996 0.004 0.000
C79 Secondary malignant neoplasm of other sites
0.996 0.004 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.993 0.007 0.000
Z88.5 Personal history of allergy to narcotic agent
0.992 0.008 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.991 0.009 0.000
C15-C26 Malignant neoplasms of digestive organs
0.991 0.009 0.000
A41 Other septicaemia
0.989 0.011 0.000
Z98.1 Arthrodesis status
0.986 0.014 0.000
Z92 Personal history of medical treatment
0.985 0.015 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.979 0.021 0.000
M54.9 Dorsalgia, unspecified
0.978 0.022 0.000
C78.0 Secondary malignant neoplasm of lung
0.977 0.023 0.000
Z92.3 Personal history of irradiation
0.977 0.023 0.000
M50 Cervical disk disorders
0.975 0.025 0.000
C18 Malignant neoplasm of colon
0.974 0.026 0.000
A41.5 Septicaemia due to other Gram-negative organisms
0.972 0.028 0.000
M20-M25 Other joint disorders
0.967 0.033 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.964 0.036 0.000
Z60 Problems related to social environment
0.963 0.037 0.000
M45-M49 Spondylopathies
0.963 0.037 0.000
E10-E14 Diabetes mellitus
0.960 0.040 0.000
C64-C68 Malignant neoplasms of urinary tract
0.959 0.041 0.000
M24 Other specific joint derangements
0.957 0.043 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.953 0.047 0.000
M54.1 Radiculopathy
0.952 0.048 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.946 0.054 0.000
A41.9 Septicaemia, unspecified
0.945 0.055 0.000
Chapter V Mental and behavioural disorders
0.944 0.056 0.000
Z60.2 Living alone
0.943 0.057 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.938 0.062 0.000
M50.2 Other cervical disk displacement
0.938 0.062 0.000
C78.2 Secondary malignant neoplasm of pleura
0.932 0.068 0.000
M54.3 Sciatica
0.930 0.070 0.000
A49 Bacterial infection of unspecified site
0.928 0.072 0.000
C67 Malignant neoplasm of bladder
0.926 0.074 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.924 0.076 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.924 0.076 0.000
E10 Insulin-dependent diabetes mellitus
0.922 0.078 0.000
C18.9 Colon, unspecified
0.921 0.079 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.920 0.080 0.000
Z88.1 Personal history of allergy to other antibiotic agents
0.914 0.086 0.000
F22 Persistent delusional disorders
0.908 0.092 0.000
Z98.8 Other specified postsurgical states
0.907 0.093 0.000
M86-M90 Other osteopathies
0.905 0.095 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.905 0.095 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.897 0.103 0.000
F22.0 Delusional disorder
0.897 0.103 0.000
C20 Malignant neoplasm of rectum
0.893 0.107 0.000
M47 Spondylosis
0.890 0.110 0.000
E10.9 Without complications
0.884 0.116 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.882 0.118 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.881 0.119 0.000
E40-E46 Malnutrition
0.878 0.122 0.000
M24.1 Other articular cartilage disorders
0.874 0.126 0.000
M47.8 Other spondylosis
0.873 0.127 0.000
C34 Malignant neoplasm of bronchus and lung
0.872 0.128 0.000
M54.16 Radiculopathy (Lumbar region)
0.871 0.129 0.000
C67.9 Bladder, unspecified
0.871 0.129 0.000
Z91.0 Personal history of allergy, other than to drugs and biological substances
0.870 0.130 0.000
C18.5 Splenic flexure
0.867 0.133 0.000
C18.3 Hepatic flexure
0.866 0.134 0.000
Z91.1 Personal history of noncompliance with medical treatment and regimen
0.866 0.134 0.000
Z63 Other problems related to primary support group, including family circumstances
0.865 0.135 0.000
C78.7 Secondary malignant neoplasm of liver
0.865 0.135 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.863 0.137 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.863 0.137 0.000
E20-E35 Disorders of other endocrine glands
0.859 0.141 0.000
E14 Unspecified diabetes mellitus
0.857 0.143 0.000
Z88.2 Personal history of allergy to sulphonamides
0.855 0.145 0.000
M05-M14 Inflammatory polyarthropathies
0.854 0.146 0.000
M89 Other disorders of bone
0.854 0.146 0.000
Z83 Family history of other specific disorders
0.853 0.147 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.851 0.149 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.847 0.153 0.000
A49.8 Other bacterial infections of unspecified site
0.846 0.154 0.000
Z57 Occupational exposure to risk-factors
0.841 0.159 0.000
M23 Internal derangement of knee
0.841 0.159 0.000
M40-M43 Deforming dorsopathies
0.838 0.162 0.000
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances
0.837 0.163 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.835 0.165 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.834 0.166 0.000
M54.12 Radiculopathy (Cervical region)
0.830 0.170 0.000
Chapter XX External causes of morbidity and mortality
0.830 0.170 0.000
A00-A09 Intestinal infectious diseases
0.829 0.171 0.000
M25 Other joint disorders, not elsewhere classified
0.829 0.171 0.000
Z88.4 Personal history of allergy to anaesthetic agent
0.826 0.174 0.000
Z98.0 Intestinal bypass and anastomosis status
0.824 0.176 0.000
M50.0 Cervical disk disorder with myelopathy
0.823 0.177 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.819 0.181 0.000
B99-B99 Other infectious diseases
0.818 0.182 0.000
B00 Herpesviral [herpes simplex] infections
0.814 0.186 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.813 0.187 0.000
E46 Unspecified protein-energy malnutrition
0.806 0.194 0.000
Z92.2 Personal history of long-term (current) use of other medicaments
0.806 0.194 0.000
Z92.4 Personal history of major surgery, not elsewhere classified
0.805 0.195 0.000
C34.1 Upper lobe, bronchus or lung
0.805 0.195 0.000
E65-E68 Obesity and other hyperalimentation
0.805 0.195 0.000
M54.39 Sciatica (Site unspecified)
0.798 0.202 0.000
E14.3 With ophthalmic complications
0.798 0.202 0.000
Z84 Family history of other conditions
0.797 0.202 0.000
M48 Other spondylopathies
0.796 0.204 0.000
A49.0 Staphylococcal infection, unspecified
0.796 0.204 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.793 0.207 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.791 0.209 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.790 0.210 0.000
C34.9 Bronchus or lung, unspecified
0.790 0.210 0.000
Q50-Q56 Congenital malformations of genital organs
0.787 0.213 0.000
M54.6 Pain in thoracic spine
0.786 0.214 0.000
M47.89 Other spondylosis (Site unspecified)
0.785 0.215 0.000
C18.6 Descending colon
0.785 0.215 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.783 0.217 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.781 0.219 0.000
A46 Erysipelas
0.777 0.222 0.000
M80-M85 Disorders of bone density and structure
0.776 0.224 0.000
M54.36 Sciatica (Lumbar region)
0.774 0.226 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.769 0.231 0.000
M45 Ankylosing spondylitis
0.768 0.232 0.000
M25.5 Pain in joint
0.767 0.233 0.000
M60-M63 Disorders of muscles
0.767 0.233 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.766 0.234 0.000
M47.87 Other spondylosis (Lumbosacral region)
0.765 0.235 0.000
M24.0 Loose body in joint
0.765 0.235 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.762 0.238 0.000
M24.2 Disorder of ligament
0.761 0.238 0.000
E10.8 With unspecified complications
0.760 0.240 0.000
M47.82 Other spondylosis (Cervical region)
0.760 0.240 0.000
C18.1 Appendix
0.759 0.241 0.000
F03 Unspecified dementia
0.759 0.241 0.000
Z92.6 Personal history of chemotherapy for neoplastic disease
0.758 0.242 0.000
C65 Malignant neoplasm of renal pelvis
0.756 0.244 0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)
0.755 0.245 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.755 0.245 0.000
Q80-Q89 Other congenital malformations
0.755 0.245 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.755 0.245 0.000
B65-B83 Helminthiases
0.754 0.246 0.000
Z80 Family history of malignant neoplasm
0.754 0.246 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.754 0.246 0.000
M10 Gout
0.753 0.247 0.000
A41.1 Septicaemia due to other specified staphylococcus
0.753 0.247 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.752 0.248 0.000
B25-B34 Other viral diseases
0.751 0.248 0.000
A48 Other bacterial diseases, not elsewhere classified
0.751 0.249 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.750 0.250 0.000
M50.1 Cervical disk disorder with radiculopathy
0.748 0.252 0.000
M91-M94 Chondropathies
0.748 0.252 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.748 0.252 0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)
0.744 0.256 0.000
Q21 Congenital malformations of cardiac septa
0.743 0.257 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.743 0.257 0.000
Z93 Artificial opening status
0.742 0.258 0.000
M89.9 Disorder of bone, unspecified
0.741 0.259 0.000
M54.19 Radiculopathy (Site unspecified)
0.741 0.259 0.000
Z83.3 Family history of diabetes mellitus
0.739 0.261 0.000
C67.5 Bladder neck
0.737 0.262 0.000
C79.6 Secondary malignant neoplasm of ovary
0.737 0.262 0.000
M54.38 Sciatica (Sacral and sacrococcygeal region)
0.736 0.264 0.000
C17 Malignant neoplasm of small intestine
0.735 0.264 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.735 0.265 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.735 0.265 0.000
M46 Other inflammatory spondylopathies
0.735 0.265 0.000
Z64 Problems related to certain psychosocial circumstances
0.734 0.265 0.000
A41.2 Septicaemia due to unspecified staphylococcus
0.733 0.266 0.000
C77.8 Lymph nodes of multiple regions
0.733 0.267 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.732 0.268 0.000
M53 Other dorsopathies, not elsewhere classified
0.732 0.268 0.000
Z98.2 Presence of cerebrospinal fluid drainage device
0.732 0.268 0.000
F29 Unspecified nonorganic psychosis
0.731 0.269 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.731 0.269 0.000
M24.5 Contracture of joint
0.729 0.271 0.000
E50-E64 Other nutritional deficiencies
0.729 0.271 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.727 0.273 0.000
E10.2 With renal complications
0.726 0.274 0.000
C67.0 Trigone of bladder
0.726 0.274 0.000
C67.2 Lateral wall of bladder
0.726 0.274 0.000
F60-F69 Disorders of adult personality and behaviour
0.724 0.276 0.000
Q27 Other congenital malformations of peripheral vascular system
0.724 0.276 0.000
E23 Hypofunction and other disorders of pituitary gland
0.723 0.277 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.723 0.277 0.000
E10.0 With coma
0.722 0.278 0.000
F23 Acute and transient psychotic disorders
0.721 0.279 0.000
E34 Other endocrine disorders
0.720 0.279 0.000
C67.8 Overlapping lesion of bladder
0.719 0.281 0.000
M25.56 Pain in joint (Lower leg)
0.719 0.281 0.000
E11 Non-insulin-dependent diabetes mellitus
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.717 0.283 0.000
C77.1 Intrathoracic lymph nodes
0.717 0.283 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.716 0.284 0.000
B50-B64 Protozoal diseases
0.716 0.284 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.716 0.284 0.000
A75-A79 Rickettsioses
0.716 0.284 0.000
A70-A74 Other diseases caused by chlamydiae
0.716 0.284 0.000
A65-A69 Other spirochaetal diseases
0.716 0.284 0.000
A20-A28 Certain zoonotic bacterial diseases
0.716 0.284 0.000
A15-A19 Tuberculosis
0.716 0.284 0.000
F80-F89 Disorders of psychological development
0.715 0.284 0.000
A44 Bartonellosis
0.714 0.285 0.000
A43 Nocardiosis
0.714 0.285 0.000
A42 Actinomycosis
0.714 0.285 0.000
A39 Meningococcal infection
0.714 0.285 0.000
A37 Whooping cough
0.714 0.285 0.000
A36 Diphtheria
0.714 0.285 0.000
A32 Listeriosis
0.714 0.285 0.000
A31 Infection due to other mycobacteria
0.714 0.285 0.000
A30 Leprosy [Hansen's disease]
0.714 0.285 0.000
A38 Scarlet fever
0.714 0.285 0.000
A35 Other tetanus
0.714 0.285 0.000
A34 Obstetrical tetanus
0.714 0.285 0.000
A33 Tetanus neonatorum
0.714 0.285 0.000
M54.8 Other dorsalgia
0.714 0.286 0.000
M54.0 Panniculitis affecting regions of neck and back
0.714 0.286 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.714 0.286 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.712 0.288 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.712 0.288 0.000
Z83.7 Family history of diseases of the digestive system
0.711 0.289 0.000
B01 Varicella [chickenpox]
0.711 0.289 0.000
Q25 Congenital malformations of great arteries
0.711 0.289 0.000
Z65 Problems related to other psychosocial circumstances
0.711 0.289 0.000
Z62 Other problems related to upbringing
0.711 0.289 0.000
Z61 Problems related to negative life events in childhood
0.711 0.289 0.000
Z59 Problems related to housing and economic circumstances
0.711 0.289 0.000
Z58 Problems related to physical environment
0.711 0.289 0.000
Z56 Problems related to employment and unemployment
0.711 0.289 0.000
Z55 Problems related to education and literacy
0.711 0.289 0.000
M54.37 Sciatica (Lumbosacral region)
0.710 0.290 0.000
C23 Malignant neoplasm of gallbladder
0.710 0.290 0.000
M11 Other crystal arthropathies
0.710 0.290 0.000
A41.4 Septicaemia due to anaerobes
0.709 0.291 0.000
A41.3 Septicaemia due to Haemophilus influenzae
0.709 0.291 0.000
A04 Other bacterial intestinal infections
0.709 0.291 0.000
Z63.4 Disappearance and death of family member
0.708 0.291 0.000
C66 Malignant neoplasm of ureter
0.707 0.293 0.000
Z92.9 Personal history of medical treatment, unspecified
0.706 0.293 0.000
Z92.5 Personal history of rehabilitation measures
0.706 0.293 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.706 0.294 0.000
B00.1 Herpesviral vesicular dermatitis
0.705 0.295 0.000
Z92.0 Personal history of contraception
0.704 0.296 0.000
M24.13 Other articular cartilage disorders (Forearm)
0.703 0.297 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.701 0.299 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.701 0.299 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.701 0.299 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.701 0.299 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.701 0.299 0.000
M50.9 Cervical disk disorder, unspecified
0.699 0.301 0.000
M50.8 Other cervical disk disorders
0.699 0.301 0.000
C18.8 Overlapping lesion of colon
0.698 0.302 0.000
Z57.3 Occupational exposure to other air contaminants
0.697 0.303 0.000
Y95 Nosocomial condition
0.696 0.304 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.695 0.305 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.694 0.306 0.000
M33 Dermatopolymyositis
0.694 0.306 0.000
M32 Systemic lupus erythematosus
0.694 0.306 0.000
M30 Polyarteritis nodosa and related conditions
0.694 0.306 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.693 0.307 0.000
Z91.8 Personal history of other specified risk-factors, not elsewhere classified
0.692 0.307 0.000
M89.0 Algoneurodystrophy
0.692 0.308 0.000
M48.0 Spinal stenosis
0.692 0.308 0.000
Chapter XXII Codes for special purposes
0.691 0.309 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.691 0.309 0.000
Q35-Q37 Cleft lip and cleft palate
0.691 0.309 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.691 0.309 0.000
Z60.9 Problem related to social environment, unspecified
0.690 0.309 0.000
Z60.8 Other problems related to social environment
0.690 0.309 0.000
Z60.5 Target of perceived adverse discrimination and persecution
0.690 0.309 0.000
Z60.4 Social exclusion and rejection
0.690 0.309 0.000
Z60.3 Acculturation difficulty
0.690 0.309 0.000
Z60.1 Atypical parenting situation
0.690 0.309 0.000
Z60.0 Problems of adjustment to life-cycle transitions
0.690 0.309 0.000
M49 Spondylopathies in diseases classified elsewhere
0.690 0.310 0.000
B00.9 Herpesviral infection, unspecified
0.690 0.310 0.000
B02 Zoster [herpes zoster]
0.689 0.311 0.000
E12 Malnutrition-related diabetes mellitus
0.688 0.312 0.000
Q28 Other congenital malformations of circulatory system
0.688 0.312 0.000
B15-B19 Viral hepatitis
0.688 0.312 0.000
B99 Other and unspecified infectious diseases
0.688 0.312 0.000
M89.8 Other specified disorders of bone
0.688 0.312 0.000
E20 Hypoparathyroidism
0.688 0.312 0.000
C68 Malignant neoplasm of other and unspecified urinary organs
0.687 0.313 0.000
C77.9 Lymph node, unspecified
0.687 0.313 0.000
E29 Testicular dysfunction
0.687 0.313 0.000
M24.9 Joint derangement, unspecified
0.686 0.313 0.000
M24.7 Protrusio acetabuli
0.686 0.313 0.000
M24.6 Ankylosis of joint
0.686 0.313 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.686 0.313 0.000
A40 Streptococcal septicaemia
0.686 0.314 0.000
S90-S99 Injuries to the ankle and foot
0.686 0.314 0.000
Z83.4 Family history of other endocrine, nutritional and metabolic diseases
0.685 0.315 0.000
C09 Malignant neoplasm of tonsil
0.685 0.315 0.000
C18.7 Sigmoid colon
0.685 0.315 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.684 0.316 0.000
Z97 Presence of other devices
0.683 0.317 0.000
F01 Vascular dementia
0.683 0.317 0.000
A80-A89 Viral infections of the central nervous system
0.682 0.317 0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)
0.682 0.318 0.000
M54.15 Radiculopathy (Thoracolumbar region)
0.682 0.318 0.000
M54.14 Radiculopathy (Thoracic region)
0.682 0.318 0.000
M54.13 Radiculopathy (Cervicothoracic region)
0.682 0.318 0.000
M54.11 Radiculopathy (Occipito-atlanto-axial region)
0.682 0.318 0.000
M54.10 Radiculopathy (Multiple sites in spine)
0.682 0.318 0.000
C79.2 Secondary malignant neoplasm of skin
0.682 0.318 0.000
M10.9 Gout, unspecified
0.681 0.319 0.000
E66 Obesity
0.681 0.319 0.000
E26 Hyperaldosteronism
0.680 0.320 0.000
M50.3 Other cervical disk degeneration
0.680 0.320 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.679 0.321 0.000
Z91.7 Personal history of female genital mutilation
0.678 0.322 0.000
Z91.4 Personal history of psychological trauma, not elsewhere classified
0.678 0.322 0.000
Z91.3 Personal history of unhealthy sleep-wake schedule
0.678 0.322 0.000
Z91.2 Personal history of poor personal hygiene
0.678 0.322 0.000
M34 Systemic sclerosis
0.678 0.322 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.678 0.322 0.000
M25.3 Other instability of joint
0.677 0.322 0.000
A49.9 Bacterial infection, unspecified
0.677 0.323 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.677 0.323 0.000
F70-F79 Mental retardation
0.677 0.323 0.000
M88 Paget's disease of bone [osteitis deformans]
0.676 0.324 0.000
E13 Other specified diabetes mellitus
0.676 0.324 0.000
E10.3 With ophthalmic complications
0.675 0.325 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.674 0.325 0.000
M00-M03 Infectious arthropathies
0.674 0.326 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.673 0.327 0.000
M47.1 Other spondylosis with myelopathy
0.673 0.327 0.000
M54.4 Lumbago with sciatica
0.672 0.328 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.671 0.329 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.670 0.330 0.000
Z63.0 Problems in relationship with spouse or partner
0.670 0.330 0.000
M41 Scoliosis
0.670 0.330 0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)
0.669 0.331 0.000
Z63.8 Other specified problems related to primary support group
0.668 0.332 0.000
M54.35 Sciatica (Thoracolumbar region)
0.667 0.333 0.000
M54.34 Sciatica-Thoracic
0.667 0.333 0.000
M54.33 Sciatica-Cervicothoracic
0.667 0.333 0.000
M54.32 Sciatica-Cervical
0.667 0.333 0.000
M54.31 Sciatica-Occipit-atl-axl
0.667 0.333 0.000
M54.30 Sciatica (Multiple sites in spine)
0.667 0.333 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.666 0.334 0.000
A49.3 Mycoplasma infection, unspecified
0.665 0.334 0.000
A49.2 Haemophilus influenzae infection, unspecified
0.665 0.334 0.000
A08 Viral and other specified intestinal infections
0.664 0.336 0.000
C69 Malignant neoplasm of eye and adnexa
0.664 0.336 0.000
C67.7 Urachus
0.664 0.336 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.663 0.337 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.662 0.337 0.000
C31 Malignant neoplasm of accessory sinuses
0.662 0.337 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.662 0.337 0.000
C37 Malignant neoplasm of thymus
0.662 0.337 0.000
C33 Malignant neoplasm of trachea
0.662 0.337 0.000
F25 Schizoaffective disorders
0.662 0.337 0.000
F28 Other nonorganic psychotic disorders
0.662 0.337 0.000
F24 Induced delusional disorder
0.662 0.337 0.000
F21 Schizotypal disorder
0.662 0.337 0.000
C67.3 Anterior wall of bladder
0.661 0.339 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.661 0.339 0.000
Z80.9 Family history of malignant neoplasm, unspecified
0.661 0.339 0.000
E10.7 With multiple complications
0.661 0.339 0.000
E10.6 With other specified complications
0.661 0.339 0.000
F02 Dementia in other diseases classified elsewhere
0.660 0.340 0.000
C18.0 Caecum
0.658 0.342 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.658 0.342 0.000
M35 Other systemic involvement of connective tissue
0.657 0.343 0.000
M40 Kyphosis and lordosis
0.657 0.343 0.000
C67.1 Dome of bladder
0.656 0.344 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.656 0.344 0.000
M23.5 Chronic instability of knee
0.653 0.347 0.000
Z84.8 Family history of other specified conditions
0.652 0.347 0.000
M23.8 Other internal derangements of knee
0.652 0.348 0.000
Q21.1 Atrial septal defect
0.651 0.348 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.651 0.349 0.000
M89.3 Hypertrophy of bone
0.651 0.349 0.000
F22.9 Persistent delusional disorder, unspecified
0.651 0.349 0.000
F22.8 Other persistent delusional disorders
0.651 0.349 0.000
M25.4 Effusion of joint
0.650 0.350 0.000
F00 Dementia in Alzheimer's disease
0.649 0.351 0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)
0.649 0.351 0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)
0.649 0.351 0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)
0.649 0.351 0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)
0.649 0.351 0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)
0.649 0.351 0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)
0.649 0.351 0.000
Z80.1 Family history of malignant neoplasm of trachea, bronchus and lung
0.648 0.352 0.000
C34.0 Main bronchus
0.647 0.353 0.000
M54.17 Radiculopathy (Lumbosacral region)
0.647 0.353 0.000
E11.3 With ophthalmic complications
0.646 0.354 0.000
C49.2 Connective and soft tissue of lower limb, including hip
0.646 0.354 0.000
M89.5 Osteolysis
0.646 0.354 0.000
M85 Other disorders of bone density and structure
0.645 0.355 0.000
M89.94 Disorder of bone, unspecified (Hand)
0.645 0.355 0.000
M22 Disorders of patella
0.645 0.355 0.000
M65-M68 Disorders of synovium and tendon
0.644 0.356 0.000
Z63.7 Other stressful life events affecting family and household
0.643 0.357 0.000
Q24 Other congenital malformations of heart
0.643 0.357 0.000
W50-W64 Exposure to animate mechanical forces
0.643 0.357 0.000
Z57.5 Occupational exposure to toxic agents in other industries
0.642 0.358 0.000
E10.5 With peripheral circulatory complications
0.642 0.358 0.000
Q00-Q07 Congenital malformations of the nervous system
0.641 0.358 0.000
Z29 Need for other prophylactic measures
0.641 0.359 0.000
C49.9 Connective and soft tissue, unspecified
0.640 0.360 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.638 0.362 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.638 0.362 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.637 0.363 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.637 0.363 0.000
M90 Osteopathies in diseases classified elsewhere
0.636 0.364 0.000
M10.99 Gout, unspecified (Site unspecified)
0.636 0.364 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.636 0.364 0.000
M54.64 Pain in thoracic spine (Thoracic region)
0.635 0.365 0.000
Z81 Family history of mental and behavioural disorders
0.634 0.366 0.000
M48.02 Spinal stenosis (Cervical region)
0.634 0.366 0.000
E28 Ovarian dysfunction
0.634 0.366 0.000
C67.6 Ureteric orifice
0.633 0.367 0.000
E23.0 Hypopituitarism
0.632 0.368 0.000
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.632 0.368 0.000
B06 Rubella [German measles]
0.632 0.368 0.000
B05 Measles
0.632 0.368 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.632 0.368 0.000
B04 Monkeypox
0.632 0.368 0.000
B03 Smallpox
0.632 0.368 0.000
A04.8 Other specified bacterial intestinal infections
0.632 0.368 0.000
Q26 Congenital malformations of great veins
0.632 0.368 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.632 0.368 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.632 0.368 0.000
C67.4 Posterior wall of bladder
0.632 0.368 0.000
Z80.5 Family history of malignant neoplasm of urinary tract
0.631 0.369 0.000
Z93.0 Tracheostomy status
0.630 0.370 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.630 0.370 0.000
E45 Retarded development following protein-energy malnutrition
0.630 0.370 0.000
E43 Unspecified severe protein-energy malnutrition
0.630 0.370 0.000
E42 Marasmic kwashiorkor
0.630 0.370 0.000
E41 Nutritional marasmus
0.630 0.370 0.000
E40 Kwashiorkor
0.630 0.370 0.000
C18.2 Ascending colon
0.629 0.371 0.000
Z57.2 Occupational exposure to dust
0.629 0.371 0.000
M54.2 Cervicalgia
0.629 0.371 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.629 0.371 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.628 0.372 0.000
C24.0 Extrahepatic bile duct
0.627 0.373 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.627 0.373 0.000
M23.9 Internal derangement of knee, unspecified
0.627 0.373 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.626 0.373 0.000
M24.18 Other articular cartilage disorders (Other)
0.626 0.373 0.000
M24.17 Other articular cartilage disorders (Ankle and foot)
0.626 0.373 0.000
M24.14 Other articular cartilage disorders (Hand)
0.626 0.373 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.626 0.373 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.626 0.373 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.626 0.374 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.626 0.374 0.000
M47.84 Other spondylosis (Thoracic region)
0.626 0.374 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.626 0.374 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.626 0.374 0.000
M87 Osteonecrosis
0.626 0.374 0.000
C34.8 Overlapping lesion of bronchus and lung
0.625 0.375 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.625 0.375 0.000
M43 Other deforming dorsopathies
0.623 0.377 0.000
B00.5 Herpesviral ocular disease
0.622 0.378 0.000
M23.4 Loose body in knee
0.622 0.378 0.000
E34.0 Carcinoid syndrome
0.621 0.379 0.000
Z63.9 Problem related to primary support group, unspecified
0.620 0.380 0.000
Z63.6 Dependent relative needing care at home
0.620 0.380 0.000
Z63.5 Disruption of family by separation and divorce
0.620 0.380 0.000
Z63.3 Absence of family member
0.620 0.380 0.000
Z63.2 Inadequate family support
0.620 0.380 0.000
Z63.1 Problems in relationship with parents and in-laws
0.620 0.380 0.000
C01 Malignant neoplasm of base of tongue
0.620 0.380 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.620 0.380 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.619 0.381 0.000
F09 Unspecified organic or symptomatic mental disorder
0.619 0.381 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.619 0.381 0.000
M31 Other necrotising vasculopathies
0.619 0.381 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.617 0.383 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.617 0.383 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.617 0.383 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.616 0.384 0.000
E32 Diseases of thymus
0.616 0.384 0.000
E31 Polyglandular dysfunction
0.616 0.384 0.000
E30 Disorders of puberty, not elsewhere classified
0.616 0.384 0.000
E25 Adrenogenital disorders
0.616 0.384 0.000
E24 Cushing's syndrome
0.616 0.384 0.000
Z88.7 Personal history of allergy to serum and vaccine
0.615 0.385 0.000
E14.8 With unspecified complications
0.614 0.386 0.000
E14.7 With multiple complications
0.614 0.386 0.000
E14.6 With other specified complications
0.614 0.386 0.000
E14.5 With peripheral circulatory complications
0.614 0.386 0.000
E14.4 With neurological complications
0.614 0.386 0.000
E14.2 Withrenal complications
0.614 0.386 0.000
E14.1 With ketoacidosis
0.614 0.386 0.000
E14.0 With coma
0.614 0.386 0.000
A41.8 Other specified septicaemia
0.614 0.386 0.000
C10 Malignant neoplasm of oropharynx
0.614 0.386 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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