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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs35624343
log Bayes Factor = 78.3892
Chromosome 6   position 32,361,762  (GRCh37) Explore rs35624343 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
C44.3 Skin of other and unspecified parts of face
1.000 0.000 0.000
E10.9 Without complications
0.000 0.000 1.000
K51.9 Ulcerative colitis, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
C44 Other malignant neoplasms of skin
1.000 0.000 0.000
K51 Ulcerative colitis
1.000 0.000 0.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
C44.7 Skin of lower limb, including hip
1.000 0.000 0.000
K50-K52 Noninfective enteritis and colitis
0.999 0.001 0.000
K50 Crohn's disease [regional enteritis]
0.999 0.001 0.000
K50.1 Crohn's disease of large intestine
0.999 0.001 0.000
D86.9 Sarcoidosis, unspecified
0.000 0.003 0.997
D86 Sarcoidosis
0.000 0.003 0.997
C44.4 Skin of scalp and neck
0.996 0.004 0.000
Z93.2 Ileostomy status
0.995 0.005 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.994 0.006 0.000
D86.0 Sarcoidosis of lung
0.000 0.010 0.990
K51.4 Pseudopolyposis of colon
0.990 0.010 0.000
E10.1 With ketoacidosis
0.000 0.010 0.990
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.989 0.011 0.000
E10.3 With ophthalmic complications
0.000 0.011 0.989
C44.2 Skin of ear and external auricular canal
0.980 0.020 0.000
C44.5 Skin of trunk
0.975 0.025 0.000
C44.6 Skin of upper limb, including shoulder
0.969 0.031 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.965 0.035 0.000
K51.8 Other ulcerative colitis
0.960 0.040 0.000
C44.0 Skin of lip
0.956 0.044 0.000
K51.2 Ulcerative (chronic) proctitis
0.952 0.048 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.949 0.051 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.943 0.057 0.000
C83.3 Large cell (diffuse)
0.943 0.057 0.000
K50.9 Crohn's disease, unspecified
0.933 0.067 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.928 0.072 0.000
D86.8 Sarcoidosis of other and combined sites
0.000 0.081 0.919
C82.0 Small cleaved cell, follicular
0.910 0.090 0.000
E10-E14 Diabetes mellitus
0.000 0.096 0.904
D51 Vitamin B12 deficiency anaemia
0.000 0.098 0.902
D50-D53 Nutritional anaemias
0.000 0.100 0.900
D86.1 Sarcoidosis of lymph nodes
0.000 0.100 0.900
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.101 0.899
D80-D89 Certain disorders involving the immune mechanism
0.000 0.114 0.886
D50 Iron deficiency anaemia
0.000 0.121 0.879
D50.9 Iron deficiency anaemia, unspecified
0.000 0.123 0.877
E16.2 Hypoglycaemia, unspecified
0.000 0.129 0.871
E16 Other disorders of pancreatic internal secretion
0.000 0.129 0.871
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.131 0.869
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.132 0.868
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.132 0.868
K52 Other non-infective gastro-enteritis and colitis
0.860 0.140 0.000
E10.8 With unspecified complications
0.000 0.158 0.842
K51.5 Mucosal proctocolitis
0.837 0.163 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.169 0.831
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.830 0.170 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.172 0.828
E27 Other disorders of adrenal gland
0.000 0.180 0.820
E27.1 Primary adrenocortical insufficiency
0.000 0.183 0.817
C82.3 Follicular lymphoma grade IIIa
0.797 0.203 0.000
E10.4 With neurological complications
0.000 0.222 0.778
K90 Intestinal malabsorption
0.000 0.225 0.775
E10.0 With coma
0.000 0.226 0.774
C44.1 Skin of eyelid, including canthus
0.767 0.233 0.000
C44.9 Malignant neoplasm of skin, unspecified
0.765 0.235 0.000
K52.1 Toxic gastro-enteritis and colitis
0.762 0.238 0.000
K52.8 Other specified non-infective gastro-enteritis and colitis
0.756 0.244 0.000
E10.6 With other specified complications
0.000 0.246 0.754
C83.1 Small cleaved cell (diffuse)
0.749 0.250 0.000
C85.1 B-cell lymphoma, unspecified
0.745 0.255 0.000
K50.8 Other Crohn's disease
0.742 0.258 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.733 0.267 0.000
K52.3 Indeterminate colitis
0.732 0.268 0.000
E22 Hyperfunction of pituitary gland
0.000 0.271 0.729
C44.8 Overlapping lesion of skin
0.717 0.283 0.000
E10.7 With multiple complications
0.000 0.283 0.717
C81 Hodgkin's disease
0.716 0.284 0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.715 0.284 0.000
D86.3 Sarcoidosis of skin
0.000 0.285 0.715
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.285 0.715
E10.2 With renal complications
0.000 0.287 0.713
C82.2 Large cell, follicular
0.713 0.287 0.000
K51.0 Ulcerative (chronic) enterocolitis
0.710 0.290 0.000
C82.6 Cutaneous follicle centre lymphoma
0.709 0.290 0.000
C82.5 Diffuse follicle centre lymphoma
0.709 0.290 0.000
C82.4 Follicular lymphoma grade IIIb
0.709 0.290 0.000
D52 Folate deficiency anaemia
0.000 0.294 0.705
E16.1 Other hypoglycaemia
0.000 0.298 0.702
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.307 0.693
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.692 0.308 0.000
C94 Other leukaemias of specified cell type
0.692 0.308 0.000
C93 Monocytic leukaemia
0.692 0.308 0.000
C86 Other specified types of T/NK-cell lymphoma
0.692 0.308 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.689 0.311 0.000
C95 Leukaemia of unspecified cell type
0.682 0.318 0.000
C83.6 Undifferentiated (diffuse)
0.680 0.320 0.000
C83.5 Lymphoblastic (diffuse)
0.680 0.320 0.000
C83.4 Immunoblastic (diffuse)
0.680 0.320 0.000
C83.2 Mixed small and large cell (diffuse)
0.680 0.320 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.676 0.324 0.000
C85.0 Lymphosarcoma
0.676 0.324 0.000
E24 Cushing's syndrome
0.000 0.326 0.674
E13 Other specified diabetes mellitus
0.000 0.327 0.673
E14 Unspecified diabetes mellitus
0.000 0.328 0.672
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.328 0.672
C82.1 Mixed small cleaved and large cell, follicular
0.668 0.332 0.000
C83.7 Burkitt's tumour
0.653 0.347 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.349 0.651
E12 Malnutrition-related diabetes mellitus
0.000 0.352 0.648
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.353 0.647
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.353 0.647
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.353 0.647
D51.2 Transcobalamin II deficiency
0.000 0.353 0.647
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.353 0.647
E27.2 Addisonian crisis
0.000 0.354 0.646
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.354 0.646
E10.5 With peripheral circulatory complications
0.000 0.355 0.645
K51.1 Ulcerative (chronic) ileocolitis
0.640 0.360 0.000
D82 Immunodeficiency associated with other major defects
0.000 0.365 0.635
D81 Combined immunodeficiencies
0.000 0.365 0.635
D50.1 Sideropenic dysphagia
0.000 0.370 0.630
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.628 0.372 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.376 0.624
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.376 0.624
E16.4 Abnormal secretion of gastrin
0.000 0.376 0.624
E16.3 Increased secretion of glucagon
0.000 0.376 0.624
D53 Other nutritional anaemias
0.000 0.376 0.624
E15 Nondiabetic hypoglycaemic coma
0.000 0.377 0.623
K90.9 Intestinal malabsorption, unspecified
0.000 0.378 0.622
C88 Malignant immunoproliferative diseases
0.620 0.380 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.605 0.395 0.000
E20 Hypoparathyroidism
0.000 0.401 0.599
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.597 0.403 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.406 0.594
E32 Diseases of thymus
0.000 0.406 0.594
E31 Polyglandular dysfunction
0.000 0.406 0.594
E30 Disorders of puberty, not elsewhere classified
0.000 0.406 0.594
E25 Adrenogenital disorders
0.000 0.406 0.594
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.411 0.589
E27.5 Adrenomedullary hyperfunction
0.000 0.412 0.588
E27.0 Other adrenocortical overactivity
0.000 0.412 0.588
K90.8 Other intestinal malabsorption
0.000 0.413 0.587
C81.1 Nodular sclerosis
0.584 0.416 0.000
D55-D59 Haemolytic anaemias
0.000 0.419 0.580
C85.7 Other specified types of non-Hodgkin's lymphoma
0.571 0.429 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.566 0.434 0.000
D52.9 Folate deficiency anaemia, unspecified
0.000 0.434 0.566
E24.9 Cushing's syndrome, unspecified
0.000 0.436 0.564
E40-E46 Malnutrition
0.000 0.439 0.561
K90.3 Pancreatic steatorrhoea
0.000 0.444 0.556
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.444 0.556
K90.1 Tropical sprue
0.000 0.444 0.556
D83 Common variable immunodeficiency
0.000 0.444 0.555
E14.9 Without complications
0.000 0.454 0.546
E34 Other endocrine disorders
0.000 0.454 0.546
C81.2 Mixed cellularity
0.545 0.455 0.000
D80 Immunodeficiency with predominantly antibody defects
0.000 0.455 0.545
E27.8 Other specified disorders of adrenal gland
0.000 0.455 0.545
E22.0 Acromegaly and pituitary gigantism
0.000 0.458 0.542
C81.0 Lymphocytic predominance
0.540 0.459 0.000
E22.1 Hyperprolactinaemia
0.000 0.464 0.536
C95.0 Acute leukaemia of unspecified cell type
0.530 0.470 0.000
E21.0 Primary hyperparathyroidism
0.000 0.474 0.526
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.477 0.523
E22.8 Other hyperfunction of pituitary gland
0.000 0.477 0.523
E65-E68 Obesity and other hyperalimentation
0.000 0.481 0.519
D84 Other immunodeficiencies
0.001 0.486 0.514
C81.7 Other Hodgkin's disease
0.513 0.486 0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.513 0.486 0.000
C81.3 Lymphocytic depletion
0.513 0.486 0.000
E14.3 With ophthalmic complications
0.000 0.491 0.509
E13.9 Without complications
0.000 0.493 0.507
C84.0 Mycosis fungoides
0.507 0.493 0.000
D52.8 Other folate deficiency anaemias
0.000 0.494 0.506
D52.1 Drug-induced folate deficiency anaemia
0.000 0.494 0.506
D52.0 Dietary folate deficiency anaemia
0.000 0.494 0.506
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.499 0.501
E29 Testicular dysfunction
0.000 0.502 0.497
C84.4 Peripheral T-cell lymphoma
0.497 0.503 0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.496 0.504 0.000
C86.5 Angioimmunoblastic T-cell lymphoma
0.496 0.504 0.000
C86.4 Blastic NK-cell lymphoma
0.496 0.504 0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.496 0.504 0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.496 0.504 0.000
C86.1 Hepatosplenic T-cell lymphoma
0.496 0.504 0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.496 0.504 0.000
C93.9 Monocytic leukaemia, unspecified
0.496 0.504 0.000
C93.7 Other monocytic leukaemia
0.496 0.504 0.000
C93.3 Juvenile myelomonocytic leukaemia
0.496 0.504 0.000
C93.2 Subacute monocytic leukaemia
0.496 0.504 0.000
C93.1 Chronic monocytic leukaemia
0.496 0.504 0.000
C93.0 Acute monocytic leukaemia
0.496 0.504 0.000
C94.7 Other specified leukaemias
0.496 0.504 0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.496 0.504 0.000
C94.5 Acute myelofibrosis
0.496 0.504 0.000
C94.4 Acute panmyelosis
0.496 0.504 0.000
C94.3 Mast cell leukaemia
0.496 0.504 0.000
C94.2 Acute megakaryoblastic leukaemia
0.496 0.504 0.000
C94.1 Chronic erythraemia
0.496 0.504 0.000
C94.0 Acute erythraemia and erythroleukaemia
0.496 0.504 0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.496 0.504 0.000
C96.8 Histiocytic sarcoma
0.496 0.504 0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.496 0.504 0.000
C96.6 Unifocal Langerhans-cell histiocytosis
0.496 0.504 0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.496 0.504 0.000
C96.4 Sarcoma of dendritic cells (accessory cells)
0.496 0.504 0.000
C96.3 True histiocytic lymphoma
0.496 0.504 0.000
C96.2 Malignant mast cell tumour
0.496 0.504 0.000
C96.1 Malignant histiocytosis
0.496 0.504 0.000
C96.0 Letterer-Siwe disease
0.496 0.504 0.000
C84.9 Mature T/NK-cell lymphoma, unspecified
0.494 0.506 0.000
C84.8 Cutaneous T-cell lymphoma, unspecified
0.494 0.506 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.494 0.506 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.494 0.506 0.000
C84.3 Lymphoepithelioid lymphoma
0.494 0.506 0.000
C84.2 T-zone lymphoma
0.494 0.506 0.000
C84.1 Sezary's diease
0.494 0.506 0.000
C95.7 Other leukaemia of unspecified cell type
0.489 0.511 0.000
C95.2 Subacute leukaemia of unspecified cell type
0.489 0.511 0.000
C95.1 Chronic leukaemia of unspecified cell type
0.489 0.511 0.000
E24.8 Other Cushing's syndrome
0.000 0.516 0.483
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.516 0.483
E24.3 Ectopic ACTH syndrome
0.000 0.516 0.483
E24.2 Drug-induced Cushing's syndrome
0.000 0.516 0.483
E24.1 Nelson's syndrome
0.000 0.516 0.483
E24.0 Pituitary-dependent Cushing's disease
0.000 0.516 0.483
E13.8 With unspecified complications
0.000 0.517 0.482
E13.7 With multiple complications
0.000 0.517 0.482
E13.6 With other specified complications
0.000 0.517 0.482
E13.5 With peripheral circulatory complications
0.000 0.517 0.482
E13.4 With neurological complications
0.000 0.517 0.482
E13.3 With ophthalmic complications
0.000 0.517 0.482
E13.2 With renal complications
0.000 0.517 0.482
E13.1 With ketoacidosis
0.000 0.517 0.482
E13.0 With coma
0.000 0.517 0.482
E14.8 With unspecified complications
0.000 0.518 0.482
E14.7 With multiple complications
0.000 0.518 0.482
E14.2 Withrenal complications
0.000 0.518 0.482
E14.1 With ketoacidosis
0.000 0.518 0.482
E14.0 With coma
0.000 0.518 0.482
D59 Acquired haemolytic anaemia
0.000 0.522 0.478
C84.5 Other and unspecified T-cell lymphomas
0.472 0.528 0.000
E50-E64 Other nutritional deficiencies
0.000 0.531 0.469
K52.0 Gastro-enteritis and colitis due to radiation
0.469 0.531 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.533 0.467
E21.4 Other specified disorders of parathyroid gland
0.000 0.533 0.467
E21.2 Other hyperparathyroidism
0.000 0.533 0.467
E14.6 With other specified complications
0.000 0.534 0.466
E12.9 Without complications
0.000 0.535 0.464
E12.8 With unspecified complications
0.000 0.535 0.464
E12.7 With multiple complications
0.000 0.535 0.464
E12.6 With other specified complications
0.000 0.535 0.464
E12.5 With peripheral circulatory complications
0.000 0.535 0.464
E12.4 With neurological complications
0.000 0.535 0.464
E12.3 With ophthalmic complications
0.000 0.535 0.464
E12.2 With renal complications
0.000 0.535 0.464
E12.1 With ketoacidosis
0.000 0.535 0.464
E12.0 With coma
0.000 0.535 0.464
E14.5 With peripheral circulatory complications
0.000 0.538 0.462
D81.9 Combined immunodeficiency, unspecified
0.000 0.545 0.455
D81.8 Other combined immunodeficiencies
0.000 0.545 0.455
D81.7 Major histocompatibility complex class II deficiency
0.000 0.545 0.455
D81.6 Major histocompatibility complex class I deficiency
0.000 0.545 0.455
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.545 0.455
D81.4 Nezelof's syndrome
0.000 0.545 0.455
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.545 0.455
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.545 0.455
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.545 0.455
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.545 0.455
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.545 0.455
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.545 0.455
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.545 0.455
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.545 0.455
D82.2 Immunodeficiency with short-limbed stature
0.000 0.545 0.455
D82.1 Di George's syndrome
0.000 0.545 0.455
D82.0 Wiskott-Aldrich syndrome
0.000 0.545 0.455
E34.0 Carcinoid syndrome
0.000 0.545 0.455
D53.8 Other specified nutritional anaemias
0.000 0.552 0.447
D53.2 Scorbutic anaemia
0.000 0.552 0.447
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.552 0.447
D53.0 Protein deficiency anaemia
0.000 0.552 0.447
C91 Lymphoid leukaemia
0.445 0.554 0.001
C88.9 Malignant immunoproliferative disease, unspecified
0.445 0.555 0.000
C88.7 Other malignant immunoproliferative diseases
0.445 0.555 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.445 0.555 0.000
C88.3 Immunoproliferative small intestinal disease
0.445 0.555 0.000
C88.2 Gamma heavy chain disease
0.445 0.555 0.000
C88.1 Alpha heavy chain disease
0.445 0.555 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.556 0.444
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.557 0.443
E20.9 Hypoparathyroidism, unspecified
0.000 0.565 0.434
C90.3 Solitary plasmacytoma
0.434 0.566 0.000
C90.1 Plasma cell leukaemia
0.434 0.566 0.000
E14.4 With neurological complications
0.000 0.570 0.430
C83.0 Small cell (diffuse)
0.429 0.570 0.001
E20.8 Other hypoparathyroidism
0.000 0.570 0.429
E20.1 Pseudohypoparathyroidism
0.000 0.570 0.429
E20.0 Idiopathic hypoparathyroidism
0.000 0.570 0.429
E00-E07 Disorders of thyroid gland
0.000 0.572 0.428
D53.9 Nutritional anaemia, unspecified
0.000 0.574 0.426
E25.9 Adrenogenital disorder, unspecified
0.000 0.574 0.426
E25.8 Other adrenogenital disorders
0.000 0.574 0.426
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.574 0.426
E30.9 Disorder of puberty, unspecified
0.000 0.574 0.426
E30.8 Other disorders of puberty
0.000 0.574 0.426
E30.1 Precocious puberty
0.000 0.574 0.426
E30.0 Delayed puberty
0.000 0.574 0.426
E31.9 Polyglandular dysfunction, unspecified
0.000 0.574 0.426
E31.8 Other polyglandular dysfunction
0.000 0.574 0.426
E31.1 Polyglandular hyperfunction
0.000 0.574 0.426
E31.0 Autoimmune polyglandular failure
0.000 0.574 0.426
E32.9 Disease of thymus, unspecified
0.000 0.574 0.426
E32.8 Other diseases of thymus
0.000 0.574 0.426
E32.1 Abscess of thymus
0.000 0.574 0.426
E32.0 Persistent hyperplasia of thymus
0.000 0.574 0.426
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.574 0.426
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.574 0.426
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.574 0.426
C95.9 Leukaemia, unspecified
0.424 0.575 0.000
C92 Myeloid leukaemia
0.421 0.578 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.578 0.422
D57 Sickle-cell disorders
0.000 0.584 0.416
D55 Anaemia due to enzyme disorders
0.000 0.584 0.416
C90.0 Multiple myeloma
0.413 0.587 0.000
D59.1 Other autoimmune haemolytic anaemias
0.000 0.594 0.406
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.598 0.402
E45 Retarded development following protein-energy malnutrition
0.000 0.598 0.402
E43 Unspecified severe protein-energy malnutrition
0.000 0.598 0.402
E42 Marasmic kwashiorkor
0.000 0.598 0.402
E41 Nutritional marasmus
0.000 0.598 0.402
E40 Kwashiorkor
0.000 0.598 0.402
D83.8 Other common variable immunodeficiencies
0.000 0.601 0.398
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.601 0.398
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.601 0.398
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.601 0.398
E53 Deficiency of other B group vitamins
0.000 0.605 0.395
E34.5 Androgen resistance syndrome
0.000 0.609 0.391
E34.4 Constitutional tall stature
0.000 0.609 0.391
E34.3 Short stature, not elsewhere classified
0.000 0.609 0.391
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.609 0.391
E34.1 Other hypersecretion of intestinal hormones
0.000 0.609 0.391
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.609 0.391
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.609 0.391
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.609 0.391
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.609 0.391
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.609 0.391
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.609 0.391
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.609 0.391
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.609 0.391
E27.9 Disorder of adrenal gland, unspecified
0.001 0.613 0.386
Chapter II Neoplasms
0.384 0.616 0.000
E28 Ovarian dysfunction
0.000 0.618 0.381
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.382 0.618 0.000
C91.5 Adult T-cell leukaemia
0.380 0.619 0.001
C73 Malignant neoplasm of thyroid gland
0.380 0.620 0.000
E03 Other hypothyroidism
0.000 0.621 0.379
E66 Obesity
0.000 0.622 0.378
C90.2 Plasmacytoma, extramedullary
0.374 0.626 0.000
C88.0 Waldenstrom's macroglobulinaemia
0.372 0.627 0.000
E67 Other hyperalimentation
0.000 0.628 0.372
E68 Sequelae of hyperalimentation
0.000 0.628 0.372
D84.8 Other specified immunodeficiencies
0.000 0.631 0.368
D84.1 Defects in the complement system
0.000 0.631 0.368
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.631 0.368
J45 Asthma
0.000 0.634 0.366
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.637 0.363
E29.9 Testicular dysfunction, unspecified
0.000 0.643 0.357
E29.8 Other testicular dysfunction
0.000 0.643 0.357
E29.0 Testicular hyperfunction
0.000 0.643 0.357
C91.9 Lymphoid leukaemia, unspecified
0.356 0.643 0.001
D56 Thalassaemia
0.000 0.644 0.356
E26 Hyperaldosteronism
0.002 0.648 0.350
E34.8 Other specified endocrine disorders
0.000 0.652 0.348
E03.9 Hypothyroidism, unspecified
0.000 0.653 0.347
E53.8 Deficiency of other specified B group vitamins
0.000 0.655 0.344
D59.8 Other acquired haemolytic anaemias
0.000 0.657 0.343
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.657 0.343
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.657 0.343
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.657 0.343
D59.3 Haemolytic-uraemic syndrome
0.000 0.657 0.343
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.657 0.343
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.657 0.343
C81.9 Hodgkin's disease, unspecified
0.341 0.659 0.000
E46 Unspecified protein-energy malnutrition
0.000 0.660 0.340
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.660 0.340
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.660 0.340
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.661 0.339
D58 Other hereditary haemolytic anaemias
0.000 0.661 0.338
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.664 0.336
E63 Other nutritional deficiencies
0.000 0.664 0.336
E56 Other vitamin deficiencies
0.000 0.664 0.336
E50 Vitamin A deficiency
0.000 0.664 0.336
E60 Dietary zinc deficiency
0.000 0.664 0.336
E59 Dietary selenium deficiency
0.000 0.664 0.336
E54 Ascorbic acid deficiency
0.000 0.664 0.336
E52 Niacin deficiency [pellagra]
0.000 0.664 0.336
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.677 0.323
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.679 0.321
C91.8 Mature B-cell leukaemia Burkitt-type
0.319 0.680 0.001
C91.7 Other lymphoid leukaemia
0.319 0.680 0.001
C91.6 Prolymphocytic leukaemia of T-cell type
0.319 0.680 0.001
C91.3 Prolymphocytic leukaemia
0.319 0.680 0.001
C91.2 Subacute lymphocytic leukaemia
0.319 0.680 0.001
D83.9 Common variable immunodeficiency, unspecified
0.001 0.681 0.319
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.681 0.318
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.681 0.318
D89.3 Immune reconstitution syndrome
0.000 0.681 0.318
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.681 0.318
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.313 0.687 0.000
E51 Thiamine deficiency
0.000 0.688 0.311
E58 Dietary calcium deficiency
0.000 0.690 0.310
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.693 0.307
E00 Congenital iodine-deficiency syndrome
0.000 0.693 0.307
C92.9 Myeloid leukaemia, unspecified
0.302 0.697 0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.302 0.697 0.000
C92.7 Other myeloid leukaemia
0.302 0.697 0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.302 0.697 0.000
C92.5 Acute myelomonocytic leukaemia
0.302 0.697 0.000
C92.4 Acute promyelocytic leukaemia
0.302 0.697 0.000
C92.3 Myeloid sarcoma
0.302 0.697 0.000
C92.2 Subacute myeloid leukaemia
0.302 0.697 0.000
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.701 0.298
D55.8 Other anaemias due to enzyme disorders
0.000 0.701 0.298
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.701 0.298
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.701 0.298
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.701 0.298
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.701 0.298
D57.8 Other sickle-cell disorders
0.000 0.701 0.298
D57.3 Sickle-cell trait
0.000 0.701 0.298
D57.2 Double heterozygous sickling disorders
0.000 0.701 0.298
D57.1 Sickle-cell anaemia without crisis
0.000 0.701 0.298
D57.0 Sickle-cell anaemia with crisis
0.000 0.701 0.298
C74 Malignant neoplasm of adrenal gland
0.298 0.702 0.000
M06.9 Rheumatoid arthritis, unspecified
0.296 0.704 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.706 0.294
C43 Malignant melanoma of skin
0.293 0.707 0.000
M06 Other rheumatoid arthritis
0.290 0.710 0.000
M06.0 Seronegative rheumatoid arthritis
0.290 0.710 0.000
E66.8 Other obesity
0.000 0.710 0.290
E44.1 Mild protein-energy malnutrition
0.000 0.711 0.288
E44.0 Moderate protein-energy malnutrition
0.000 0.711 0.288
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.287 0.713 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.286 0.714 0.000
E53.1 Pyridoxine deficiency
0.000 0.716 0.283
E53.0 Riboflavin deficiency
0.000 0.716 0.283
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.283 0.717 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.717 0.283
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.283 0.717 0.000
D50.8 Other iron deficiency anaemias
0.000 0.720 0.280
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.720 0.279
E53.9 Vitamin B deficiency, unspecified
0.000 0.721 0.279
E06 Thyroiditis
0.000 0.721 0.279
D89.1 Cryoglobulinaemia
0.000 0.722 0.278
E34.9 Endocrine disorder, unspecified
0.001 0.723 0.277
E66.9 Obesity, unspecified
0.000 0.725 0.275
E28.9 Ovarian dysfunction, unspecified
0.000 0.726 0.274
E28.8 Other ovarian dysfunction
0.000 0.726 0.274
E28.1 Androgen excess
0.000 0.726 0.274
E28.0 Oestrogen excess
0.000 0.726 0.274
C75 Malignant neoplasm of other endocrine glands and related structures
0.274 0.726 0.000
E03.5 Myxoedema coma
0.000 0.728 0.272
E03.4 Atrophy of thyroid (acquired)
0.000 0.728 0.272
E03.3 Postinfectious hypothyroidism
0.000 0.728 0.272
E03.1 Congenital hypothyroidism without goitre
0.000 0.728 0.272
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.728 0.272
E66.1 Drug-induced obesity
0.000 0.729 0.271
C40-C41 Malignant neoplasms of bone and articular cartilage
0.270 0.730 0.000
E67.8 Other specified hyperalimentation
0.000 0.733 0.267
E67.3 Hypervitaminosis D
0.000 0.733 0.267
E67.2 Megavitamin-B6 syndrome
0.000 0.733 0.267
E67.1 Hypercarotenaemia
0.000 0.733 0.267
E67.0 Hypervitaminosis A
0.000 0.733 0.267
M45.X9 Ankylosing spondylitis (Site unspecified)
0.266 0.734 0.000
E61 Deficiency of other nutrient elements
0.000 0.734 0.265
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.266 0.734 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.734 0.265
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.265 0.735 0.000
C06 Malignant neoplasm of other and unspecified parts of mouth
0.263 0.737 0.000
J45.8 Mixed asthma
0.000 0.738 0.262
J45.1 Nonallergic asthma
0.000 0.738 0.262
E11.1 With ketoacidosis
0.000 0.738 0.262
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.738 0.262
E23 Hypofunction and other disorders of pituitary gland
0.001 0.739 0.260
E29.1 Testicular hypofunction
0.000 0.739 0.260
K50.0 Crohn's disease of small intestine
0.259 0.740 0.001
E65 Localised adiposity
0.000 0.742 0.257
C02.1 Border of tongue
0.257 0.743 0.000
C43.6 Malignant melanoma of upper limb, including shoulder
0.257 0.743 0.000
C91.0 Acute lymphoblastic leukaemia
0.255 0.743 0.001
D56.9 Thalassaemia, unspecified
0.000 0.744 0.255
D56.8 Other thalassaemias
0.000 0.744 0.255
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.744 0.255
D56.2 Delta-beta thalassaemia
0.000 0.744 0.255
D56.0 Alpha thalassaemia
0.000 0.744 0.255
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.255 0.745 0.000
E03.8 Other specified hypothyroidism
0.000 0.745 0.255
E26.8 Other hyperaldosteronism
0.001 0.747 0.251
E26.1 Secondary hyperaldosteronism
0.001 0.747 0.251
C05 Malignant neoplasm of palate
0.252 0.748 0.000
D56.3 Thalassaemia trait
0.000 0.748 0.251
D84.9 Immunodeficiency, unspecified
0.001 0.752 0.247
C43.4 Malignant melanoma of scalp and neck
0.248 0.752 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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