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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs374205
log Bayes Factor = 41.9921
Chromosome 6   position 32,196,873  (GRCh37) Explore rs374205 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter X Diseases of the respiratory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.001 0.999
E03.9 Hypothyroidism, unspecified
0.000 0.001 0.999
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.001 0.999
M05-M14 Inflammatory polyarthropathies
0.000 0.001 0.999
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.002 0.998
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
L40-L45 Papulosquamous disorders
0.000 0.002 0.998
L40 Psoriasis
0.000 0.003 0.997
D50-D53 Nutritional anaemias
0.000 0.004 0.996
J09-J18 Influenza and pneumonia
0.000 0.005 0.995
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.006 0.994
J20-J22 Other acute lower respiratory infections
0.000 0.007 0.993
J18 Pneumonia, organism unspecified
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.008 0.992
D50 Iron deficiency anaemia
0.000 0.010 0.990
L40.5 Arthropathic psoriasis
0.000 0.011 0.989
J18.9 Pneumonia, unspecified
0.000 0.012 0.988
J84 Other interstitial pulmonary diseases
0.000 0.012 0.988
H02 Other disorders of eyelid
0.000 0.014 0.986
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.016 0.984
Chapter I Certain infectious and parasitic diseases
0.000 0.017 0.983
J22 Unspecified acute lower respiratory infection
0.000 0.018 0.982
M05 Seropositive rheumatoid arthritis
0.000 0.021 0.979
E10.1 With ketoacidosis
0.000 0.021 0.979
L40.9 Psoriasis, unspecified
0.000 0.022 0.978
D50.8 Other iron deficiency anaemias
0.000 0.031 0.969
J80 Adult respiratory distress syndrome
0.000 0.033 0.967
L20-L30 Dermatitis and eczema
0.000 0.034 0.966
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.035 0.965
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.035 0.965
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.038 0.962
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.043 0.957
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.046 0.954
B35-B49 Mycoses
0.000 0.057 0.943
H02.1 Ectropion of eyelid
0.000 0.061 0.939
J18.1 Lobar pneumonia, unspecified
0.000 0.064 0.936
B37 Candidiasis
0.000 0.074 0.926
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.000 0.075 0.925
H33 Retinal detachments and breaks
0.000 0.082 0.918
B37.8 Candidiasis of other sites
0.000 0.083 0.917
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.084 0.916
J30-J39 Other diseases of upper respiratory tract
0.000 0.088 0.912
H02.0 Entropion and trichiasis of eyelid
0.000 0.088 0.912
L98.8 Other specified disorders of skin and subcutaneous tissue
0.000 0.089 0.911
E11 Non-insulin-dependent diabetes mellitus
0.000 0.092 0.908
M06.0 Seronegative rheumatoid arthritis
0.000 0.097 0.903
A50-A64 Infections with a predominantly sexual mode of transmission
0.000 0.097 0.903
M07 Psoriatic and enteropathic arthropathies
0.000 0.102 0.898
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.103 0.897
J81 Pulmonary oedema
0.000 0.105 0.895
J32 Chronic sinusitis
0.000 0.107 0.893
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.107 0.893
J33 Nasal polyp
0.000 0.108 0.892
D60-D64 Aplastic and other anaemias
0.000 0.109 0.891
E10.5 With peripheral circulatory complications
0.000 0.109 0.891
E11.3 With ophthalmic complications
0.000 0.110 0.890
L29 Pruritus
0.000 0.112 0.888
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.115 0.885
B25-B34 Other viral diseases
0.000 0.120 0.880
H04 Disorders of lachrymal system
0.000 0.121 0.879
H33.2 Serous retinal detachment
0.000 0.123 0.877
J20 Acute bronchitis
0.000 0.126 0.874
E10.4 With neurological complications
0.000 0.126 0.873
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.129 0.871
E50-E64 Other nutritional deficiencies
0.000 0.130 0.870
D61 Other aplastic anaemias
0.000 0.140 0.860
M35 Other systemic involvement of connective tissue
0.000 0.141 0.859
M35.3 Polymyalgia rheumatica
0.000 0.143 0.857
E10.2 With renal complications
0.000 0.144 0.856
M20-M25 Other joint disorders
0.000 0.144 0.856
D50.9 Iron deficiency anaemia, unspecified
0.000 0.144 0.856
E14 Unspecified diabetes mellitus
0.000 0.145 0.855
M10 Gout
0.000 0.146 0.854
J33.0 Polyp of nasal cavity
0.000 0.148 0.852
H53-H54 Visual disturbances and blindness
0.000 0.148 0.852
J32.9 Chronic sinusitis, unspecified
0.000 0.149 0.851
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.000 0.155 0.845
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.155 0.845
D51 Vitamin B12 deficiency anaemia
0.000 0.160 0.840
D61.9 Aplastic anaemia, unspecified
0.000 0.162 0.838
B37.0 Candidal stomatitis
0.000 0.163 0.837
H02.3 Blepharochalasis
0.000 0.165 0.835
E06 Thyroiditis
0.000 0.165 0.835
L82 Seborrhoeic keratosis
0.000 0.174 0.826
M07.3 Other psoriatic arthropathies
0.000 0.174 0.826
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.178 0.822
H02.9 Disorder of eyelid, unspecified
0.000 0.178 0.822
L27 Dermatitis due to substances taken internally
0.000 0.179 0.821
D52 Folate deficiency anaemia
0.000 0.180 0.820
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.181 0.819
M35.0 Sicca syndrome [Sjogren]
0.000 0.185 0.815
J14 Pneumonia due to Haemophilus influenzae
0.000 0.185 0.815
H33.3 Retinal breaks without detachment
0.000 0.186 0.814
L85 Other epidermal thickening
0.000 0.187 0.813
A63.0 Anogenital (venereal) warts
0.000 0.196 0.804
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.196 0.804
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.199 0.801
H55-H59 Other disorders of eye and adnexa
0.000 0.199 0.801
A00-A09 Intestinal infectious diseases
0.000 0.201 0.799
J10 Influenza due to identified influenza virus
0.000 0.204 0.796
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.207 0.793
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.209 0.791
H02.5 Other disorders affecting eyelid function
0.000 0.210 0.790
L28 Lichen simplex chronicus and prurigo
0.000 0.210 0.790
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.210 0.790
J20.9 Acute bronchitis, unspecified
0.000 0.211 0.789
L83 Acanthosis nigricans
0.000 0.214 0.785
J32.8 Other chronic sinusitis
0.000 0.215 0.785
E55 Vitamin D deficiency
0.000 0.217 0.783
L98.4 Chronic ulcer of skin, not elsewhere classified
0.000 0.219 0.780
J33.9 Nasal polyp, unspecified
0.000 0.221 0.779
E20-E35 Disorders of other endocrine glands
0.000 0.221 0.779
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.000 0.223 0.777
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.227 0.773
L98.0 Pyogenic granuloma
0.000 0.228 0.772
M60-M63 Disorders of muscles
0.000 0.231 0.769
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.236 0.764
L29.0 Pruritus ani
0.000 0.236 0.764
M06.3 Rheumatoid nodule
0.000 0.238 0.762
E27 Other disorders of adrenal gland
0.000 0.238 0.762
A80-A89 Viral infections of the central nervous system
0.000 0.239 0.761
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.240 0.760
D55-D59 Haemolytic anaemias
0.000 0.243 0.757
J11 Influenza, virus not identified
0.000 0.245 0.755
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.250 0.750
M10.9 Gout, unspecified
0.000 0.250 0.750
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.250 0.750
L93 Lupus erythematosus
0.000 0.251 0.749
A08 Viral and other specified intestinal infections
0.000 0.252 0.748
B34 Viral infection of unspecified site
0.000 0.253 0.747
H35 Other retinal disorders
0.000 0.254 0.746
B20-B24 Human immunodeficiency virus [HIV] disease
0.000 0.254 0.746
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.255 0.745
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.255 0.744
J32.0 Chronic maxillary sinusitis
0.000 0.256 0.744
H02.4 Ptosis of eyelid
0.000 0.257 0.743
E14.3 With ophthalmic complications
0.000 0.260 0.740
B25 Cytomegaloviral disease
0.000 0.260 0.740
B15-B19 Viral hepatitis
0.000 0.262 0.738
H02.6 Xanthelasma of eyelid
0.000 0.262 0.738
H04.8 Other disorders of lachrymal system
0.000 0.265 0.735
H05 Disorders of orbit
0.000 0.266 0.734
E11.1 With ketoacidosis
0.000 0.268 0.732
E27.1 Primary adrenocortical insufficiency
0.000 0.269 0.731
L20 Atopic dermatitis
0.000 0.270 0.730
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.270 0.730
J17 Pneumonia in diseases classified elsewhere
0.000 0.271 0.729
H34 Retinal vascular occlusions
0.000 0.271 0.729
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.272 0.728
B65-B83 Helminthiases
0.000 0.273 0.727
L57.0 Actinic keratosis
0.000 0.274 0.726
H53 Visual disturbances
0.000 0.275 0.725
D68 Other coagulation defects
0.000 0.277 0.723
E11.2 With renal complications
0.000 0.277 0.723
E06.3 Autoimmune thyroiditis
0.000 0.278 0.722
J35 Chronic diseases of tonsils and adenoids
0.000 0.278 0.722
M14 Arthropathies in other diseases classified elsewhere
0.000 0.278 0.721
E55.9 Vitamin D deficiency, unspecified
0.000 0.279 0.721
H35.8 Other specified retinal disorders
0.000 0.280 0.720
H33.4 Traction detachment of retina
0.000 0.281 0.719
L29.2 Pruritus vulvae
0.000 0.281 0.719
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.282 0.718
E07 Other disorders of thyroid
0.000 0.283 0.717
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
H30 Chorioretinal inflammation
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M12 Other specific arthropathies
0.000 0.284 0.716
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.284 0.716
M08 Juvenile arthritis
0.000 0.284 0.716
J15 Bacterial pneumonia, not elsewhere classified
0.000 0.284 0.716
L44 Other papulosquamous disorders
0.000 0.285 0.715
L41 Parapsoriasis
0.000 0.285 0.715
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.285 0.715
L40.8 Other psoriasis
0.000 0.285 0.715
L40.4 Guttate psoriasis
0.000 0.285 0.715
L40.3 Pustulosis palmaris et plantaris
0.000 0.285 0.715
L40.2 Acrodermatitis continua
0.000 0.285 0.715
L40.1 Generalised pustular psoriasis
0.000 0.285 0.715
L42 Pityriasis rosea
0.000 0.286 0.714
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.286 0.714
D53 Other nutritional anaemias
0.000 0.286 0.714
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.000 0.286 0.714
J09 Influenza due to certain identified influenza virus
0.000 0.286 0.714
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.287 0.713
J21 Acute bronchiolitis
0.000 0.288 0.712
J18.2 Hypostatic pneumonia, unspecified
0.000 0.288 0.711
D50.1 Sideropenic dysphagia
0.000 0.290 0.710
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.292 0.708
J84.8 Other specified interstitial pulmonary diseases
0.000 0.292 0.708
J84.0 Alveolar and parietoalveolar conditions
0.000 0.292 0.708
E10.6 With other specified complications
0.000 0.292 0.708
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.293 0.707
M06.4 Inflammatory polyarthropathy
0.000 0.295 0.705
B85-B89 Pediculosis, acariasis and other infestations
0.000 0.295 0.705
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.000 0.295 0.705
A75-A79 Rickettsioses
0.000 0.295 0.705
A70-A74 Other diseases caused by chlamydiae
0.000 0.295 0.705
A20-A28 Certain zoonotic bacterial diseases
0.000 0.295 0.705
D64 Other anaemias
0.000 0.295 0.705
A08.1 Acute gastro-enteropathy due to Norwalk agent
0.000 0.296 0.704
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.296 0.703
L29.9 Pruritus, unspecified
0.000 0.297 0.703
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.297 0.703
M05.8 Other seropositive rheumatoid arthritis
0.000 0.298 0.702
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.298 0.702
M05.2 Rheumatoid vasculitis
0.000 0.298 0.702
M05.1 Rheumatoid lung disease
0.000 0.298 0.702
M05.0 Felty's syndrome
0.000 0.298 0.702
A30-A49 Other bacterial diseases
0.000 0.300 0.700
M11 Other crystal arthropathies
0.000 0.301 0.699
L85.8 Other specified epidermal thickening
0.000 0.302 0.698
B35 Dermatophytosis
0.000 0.303 0.697
E65-E68 Obesity and other hyperalimentation
0.000 0.303 0.697
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.303 0.697
D52.9 Folate deficiency anaemia, unspecified
0.000 0.306 0.694
B50-B64 Protozoal diseases
0.000 0.306 0.694
L25 Unspecified contact dermatitis
0.000 0.307 0.693
L24 Irritant contact dermatitis
0.000 0.307 0.693
L23 Allergic contact dermatitis
0.000 0.307 0.693
L21 Seborrhoeic dermatitis
0.000 0.307 0.693
L26 Exfoliative dermatitis
0.000 0.307 0.693
L22 Diaper [napkin] dermatitis
0.000 0.307 0.693
H00 Hordeolum and chalazion
0.000 0.308 0.692
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.308 0.692
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.308 0.692
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.308 0.692
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.308 0.692
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.308 0.692
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.308 0.692
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.308 0.692
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.308 0.692
G35 Multiple sclerosis
0.000 0.309 0.691
A65-A69 Other spirochaetal diseases
0.000 0.309 0.691
M10.99 Gout, unspecified (Site unspecified)
0.000 0.309 0.691
E16 Other disorders of pancreatic internal secretion
0.000 0.311 0.689
J33.8 Other polyp of sinus
0.000 0.312 0.688
L30 Other dermatitis
0.000 0.313 0.687
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.313 0.686
L87 Transepidermal elimination disorders
0.000 0.313 0.686
L88 Pyoderma gangrenosum
0.000 0.313 0.686
L86 Keratoderma in diseases classified elsewhere
0.000 0.313 0.686
E11.8 With unspecified complications
0.000 0.315 0.685
H35.4 Peripheral retinal degeneration
0.000 0.315 0.685
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.000 0.316 0.684
B49 Unspecified mycosis
0.000 0.317 0.682
E40-E46 Malnutrition
0.000 0.318 0.682
J35.0 Chronic tonsillitis
0.000 0.318 0.682
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.318 0.682
L10-L14 Bullous disorders
0.000 0.318 0.682
E05.8 Other thyrotoxicosis
0.000 0.318 0.682
M34 Systemic sclerosis
0.000 0.318 0.682
K90 Intestinal malabsorption
0.670 0.320 0.011
B90-B94 Sequelae of infectious and parasitic diseases
0.000 0.322 0.678
B48 Other mycoses, not elsewhere classified
0.000 0.324 0.676
B47 Mycetoma
0.000 0.324 0.676
B46 Zygomycosis
0.000 0.324 0.676
B45 Cryptococcosis
0.000 0.324 0.676
B43 Chromomycosis and phaeomycotic abscess
0.000 0.324 0.676
B42 Sporotrichosis
0.000 0.324 0.676
B41 Paracoccidioidomycosis
0.000 0.324 0.676
B40 Blastomycosis
0.000 0.324 0.676
B39 Histoplasmosis
0.000 0.324 0.676
B38 Coccidioidomycosis
0.000 0.324 0.676
M91-M94 Chondropathies
0.000 0.327 0.673
Chapter VI Diseases of the nervous system
0.000 0.327 0.673
H04.4 Chronic inflammation of lachrymal passages
0.000 0.328 0.672
L28.0 Lichen simplex chronicus
0.000 0.333 0.667
H02.2 Lagophthalmos
0.000 0.335 0.664
B37.7 Candidal septicaemia
0.000 0.336 0.664
B37.6 Candidal endocarditis
0.000 0.336 0.664
B37.5 Candidal meningitis
0.000 0.336 0.664
B37.2 Candidiasis of skin and nail
0.000 0.336 0.664
B37.1 Pulmonary candidiasis
0.000 0.336 0.664
L98.7 Excessive and redundant skin and subcutaneous tissue
0.000 0.336 0.663
L98.6 Other infiltrative disorders of skin and subcutaneous tissue
0.000 0.336 0.663
L98.5 Mucinosis of skin
0.000 0.336 0.663
L98.3 Eosinophilic cellulitis [Wells]
0.000 0.336 0.663
L98.1 Factitial dermatitis
0.000 0.336 0.663
L43 Lichen planus
0.000 0.339 0.661
K51.9 Ulcerative colitis, unspecified
0.000 0.339 0.661
L29.8 Other pruritus
0.000 0.341 0.659
H46 Optic neuritis
0.000 0.342 0.658
H57 Other disorders of eye and adnexa
0.000 0.343 0.656
L94 Other localised connective tissue disorders
0.000 0.344 0.655
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.347 0.653
J10.1 Influenza with other respiratory manifestations, influenza virus identified
0.000 0.347 0.653
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.000 0.347 0.653
H53.1 Subjective visual disturbances
0.000 0.347 0.653
M62 Other disorders of muscle
0.000 0.348 0.652
E11.7 With multiple complications
0.000 0.349 0.651
M31 Other necrotising vasculopathies
0.000 0.349 0.650
E04 Other non-toxic goitre
0.000 0.350 0.650
H54 Blindness and low vision
0.000 0.350 0.650
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.351 0.649
J32.4 Chronic pansinusitis
0.000 0.352 0.648
A15-A19 Tuberculosis
0.000 0.352 0.647
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.353 0.647
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.353 0.647
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.353 0.647
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.353 0.647
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.353 0.647
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.353 0.647
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.353 0.647
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.353 0.647
E53 Deficiency of other B group vitamins
0.000 0.353 0.647
A60 Anogenital herpesviral [herpes simplex] infections
0.000 0.353 0.647
A59 Trichomoniasis
0.000 0.353 0.647
A56 Other sexually transmitted chlamydial diseases
0.000 0.353 0.647
A54 Gonococcal infection
0.000 0.353 0.647
A53 Other and unspecified syphilis
0.000 0.353 0.647
A52 Late syphilis
0.000 0.353 0.647
A51 Early syphilis
0.000 0.353 0.647
A50 Congenital syphilis
0.000 0.353 0.647
A64 Unspecified sexually transmitted disease
0.000 0.353 0.647
A58 Granuloma inguinale
0.000 0.353 0.647
A57 Chancroid
0.000 0.353 0.647
A55 Chlamydial lymphogranuloma (venereum)
0.000 0.353 0.647
M07.6 Other enteropathic arthropathies
0.000 0.356 0.644
M07.5 Arthropathy in ulcerative colitis
0.000 0.356 0.644
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.356 0.644
M07.2 Psoriatic spondylitis
0.000 0.356 0.644
M07.1 Arthritis mutilans
0.000 0.356 0.644
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.356 0.644
H53.0 Amblyopia ex anopsia
0.000 0.356 0.644
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.357 0.643
B25.9 Cytomegaloviral disease, unspecified
0.000 0.360 0.640
J32.3 Chronic sphenoidal sinusitis
0.000 0.360 0.640
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.360 0.640
J33.1 Polypoid sinus degeneration
0.000 0.360 0.640
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.361 0.639
M35.1 Other overlap syndromes
0.000 0.362 0.637
L29.3 Anogenital pruritus, unspecified
0.000 0.363 0.637
L29.1 Pruritus scroti
0.000 0.363 0.637
E14.9 Without complications
0.000 0.364 0.636
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.365 0.635
L58 Radiodermatitis
0.000 0.365 0.635
L55 Sunburn
0.000 0.365 0.635
A87 Viral meningitis
0.000 0.367 0.633
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.367 0.632
L80 Vitiligo
0.000 0.369 0.631
B33 Other viral diseases, not elsewhere classified
0.000 0.369 0.631
B30 Viral conjunctivitis
0.000 0.369 0.631
B27 Infectious mononucleosis
0.000 0.369 0.631
B26 Mumps
0.000 0.369 0.631
H04.6 Other changes in lachrymal passages
0.000 0.370 0.630
H04.0 Dacryoadenitis
0.000 0.370 0.630
M00-M03 Infectious arthropathies
0.000 0.370 0.630
H04.2 Epiphora
0.000 0.371 0.629
B36 Other superficial mycoses
0.000 0.372 0.627
J20.8 Acute bronchitis due to other specified organisms
0.000 0.373 0.627
J20.7 Acute bronchitis due to echovirus
0.000 0.373 0.627
J20.6 Acute bronchitis due to rhinovirus
0.000 0.373 0.627
J20.5 Acute bronchitis due to respiratory syncytial virus
0.000 0.373 0.627
J20.4 Acute bronchitis due to parainfluenza virus
0.000 0.373 0.627
J20.3 Acute bronchitis due to coxsackie virus
0.000 0.373 0.627
J20.2 Acute bronchitis due to streptococcus
0.000 0.373 0.627
J20.1 Acute bronchitis due to Haemophilus influenzae
0.000 0.373 0.627
J20.0 Acute bronchitis due to Mycoplasma pneumoniae
0.000 0.373 0.627
M32 Systemic lupus erythematosus
0.000 0.374 0.626
D68.0 Von Willebrand's disease
0.000 0.374 0.626
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.375 0.625
H00.0 Hordeolum and other deep inflammation of eyelid
0.000 0.376 0.624
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.376 0.624
E63 Other nutritional deficiencies
0.000 0.376 0.624
E56 Other vitamin deficiencies
0.000 0.376 0.624
E51 Thiamine deficiency
0.000 0.376 0.624
E50 Vitamin A deficiency
0.000 0.376 0.624
E60 Dietary zinc deficiency
0.000 0.376 0.624
E59 Dietary selenium deficiency
0.000 0.376 0.624
E58 Dietary calcium deficiency
0.000 0.376 0.624
E54 Ascorbic acid deficiency
0.000 0.376 0.624
E52 Niacin deficiency [pellagra]
0.000 0.376 0.624
M80-M85 Disorders of bone density and structure
0.000 0.376 0.624
D68.8 Other specified coagulation defects
0.000 0.379 0.621
H55 Nystagmus and other irregular eye movements
0.000 0.381 0.619
E11.0 With coma
0.000 0.381 0.619
H40-H42 Glaucoma
0.000 0.382 0.618
D61.8 Other specified aplastic anaemias
0.000 0.383 0.616
D61.3 Idiopathic aplastic anaemia
0.000 0.383 0.616
D61.2 Aplastic anaemia due to other external agents
0.000 0.383 0.616
D61.1 Drug-induced aplastic anaemia
0.000 0.383 0.616
D61.0 Constitutional aplastic anaemia
0.000 0.383 0.616
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.384 0.616
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.384 0.616
M35.5 Multifocal fibrosclerosis
0.000 0.384 0.616
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.384 0.616
M35.2 Behcet's disease
0.000 0.384 0.616
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.386 0.614
E14.8 With unspecified complications
0.000 0.387 0.613
E14.7 With multiple complications
0.000 0.387 0.613
E14.6 With other specified complications
0.000 0.387 0.613
E14.5 With peripheral circulatory complications
0.000 0.387 0.613
E14.4 With neurological complications
0.000 0.387 0.613
E14.2 Withrenal complications
0.000 0.387 0.613
E14.1 With ketoacidosis
0.000 0.387 0.613
E14.0 With coma
0.000 0.387 0.613
M10.4 Other secondary gout
0.000 0.388 0.612
M10.3 Gout due to impairment of renal function
0.000 0.388 0.612
M10.2 Drug-induced gout
0.000 0.388 0.612
M10.1 Lead-induced gout
0.000 0.388 0.612
M10.0 Idiopathic gout
0.000 0.388 0.612
D75 Other diseases of blood and blood-forming organs
0.000 0.388 0.612
J12 Viral pneumonia, not elsewhere classified
0.000 0.388 0.611
B37.9 Candidiasis, unspecified
0.000 0.389 0.611
H10-H13 Disorders of conjunctiva
0.000 0.391 0.609
E16.2 Hypoglycaemia, unspecified
0.000 0.391 0.609
M24 Other specific joint derangements
0.000 0.393 0.607
L85.9 Epidermal thickening, unspecified
0.000 0.394 0.606
A63.8 Other specified predominantly sexually transmitted diseases
0.000 0.394 0.606
L92.8 Other granulomatous disorders of skin and subcutaneous tissue
0.000 0.394 0.606
L92.2 Granuloma faciale [eosinophilic granuloma of skin]
0.000 0.394 0.606
L92.1 Necrobiosis lipoidica, not elsewhere classified
0.000 0.394 0.606
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.000 0.395 0.605
B34.8 Other viral infections of unspecified site
0.000 0.395 0.605
B34.9 Viral infection, unspecified
0.000 0.396 0.604
D59 Acquired haemolytic anaemia
0.000 0.396 0.604
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.397 0.602
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.397 0.602
D51.2 Transcobalamin II deficiency
0.000 0.397 0.602
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.397 0.602
J32.1 Chronic frontal sinusitis
0.000 0.398 0.602
A02 Other Salmonella infections
0.000 0.401 0.599
E06.5 Other chronic thyroiditis
0.000 0.401 0.599
E06.4 Drug-induced thyroiditis
0.000 0.401 0.599
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.401 0.599
E06.1 Subacute thyroiditis
0.000 0.401 0.599
E06.0 Acute thyroiditis
0.000 0.401 0.599
L93.0 Discoid lupus erythematosus
0.000 0.401 0.599
H06.2 Dysthyroid exophthalmos
0.000 0.401 0.599
J32.2 Chronic ethmoidal sinusitis
0.000 0.404 0.595
J18.8 Other pneumonia, organism unspecified
0.000 0.405 0.595
L81 Other disorders of pigmentation
0.000 0.405 0.595
M80 Osteoporosis with pathological fracture
0.000 0.405 0.595
H01 Other inflammation of eyelid
0.000 0.406 0.594
M07.38 Other psoriatic arthropathies (Other)
0.000 0.408 0.592
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.408 0.592
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.408 0.592
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.408 0.592
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.408 0.592
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.408 0.592
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.408 0.592
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.408 0.592
M06.34 Rheumatoid nodule (Hand)
0.000 0.408 0.592
L40.0 Psoriasis vulgaris
0.000 0.409 0.591
E27.9 Disorder of adrenal gland, unspecified
0.000 0.409 0.591
E06.9 Thyroiditis, unspecified
0.000 0.410 0.590
D64.9 Anaemia, unspecified
0.000 0.410 0.590
L57.5 Actinic granuloma
0.000 0.410 0.589
L57.3 Poikiloderma of Civatte
0.000 0.410 0.589
L57.2 Cutis rhomboidalis nuchae
0.000 0.410 0.589
L57.1 Actinic reticuloid
0.000 0.410 0.589
H04.9 Disorder of lachrymal system, unspecified
0.000 0.411 0.589
L27.9 Dermatitis due to unspecified substance taken internally
0.000 0.412 0.588
L27.8 Dermatitis due to other substances taken internally
0.000 0.412 0.588
L27.2 Dermatitis due to ingested food
0.000 0.412 0.588
D52.8 Other folate deficiency anaemias
0.000 0.412 0.588
D52.1 Drug-induced folate deficiency anaemia
0.000 0.412 0.588
D52.0 Dietary folate deficiency anaemia
0.000 0.412 0.588
E15 Nondiabetic hypoglycaemic coma
0.000 0.413 0.587
H31 Other disorders of choroid
0.000 0.414 0.585
H33.1 Retinoschisis and retinal cysts
0.000 0.416 0.584

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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