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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3800307
log Bayes Factor = 72.3237
Chromosome 6   position 27,185,792  (GRCh37) Explore rs3800307 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
N40 Hyperplasia of prostate
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.998 0.002 0.000
E03 Other hypothyroidism
0.997 0.003 0.000
E10.9 Without complications
0.997 0.003 0.000
E16 Other disorders of pancreatic internal secretion
0.996 0.004 0.000
E16.2 Hypoglycaemia, unspecified
0.995 0.005 0.000
K44.9 Diaphragmatic hernia without obstruction or gangrene
0.000 0.008 0.992
E03.9 Hypothyroidism, unspecified
0.992 0.008 0.000
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.000 0.009 0.991
E14 Unspecified diabetes mellitus
0.988 0.012 0.000
K44 Diaphragmatic hernia
0.000 0.023 0.977
K40 Inguinal hernia
0.000 0.029 0.971
K40-K46 Hernia
0.000 0.039 0.961
K90 Intestinal malabsorption
0.956 0.044 0.000
K90.9 Intestinal malabsorption, unspecified
0.931 0.069 0.000
E14.9 Without complications
0.912 0.088 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.910 0.090 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.886 0.114 0.000
E10.2 With renal complications
0.877 0.123 0.000
R31 Unspecified haematuria
0.000 0.139 0.861
E10.3 With ophthalmic complications
0.857 0.143 0.000
E14.3 With ophthalmic complications
0.857 0.143 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.851 0.149 0.000
E20-E35 Disorders of other endocrine glands
0.849 0.151 0.000
E10.5 With peripheral circulatory complications
0.843 0.157 0.000
E10.1 With ketoacidosis
0.837 0.162 0.000
E27 Other disorders of adrenal gland
0.835 0.165 0.000
E07 Other disorders of thyroid
0.835 0.165 0.000
E40-E46 Malnutrition
0.831 0.169 0.000
E50-E64 Other nutritional deficiencies
0.830 0.170 0.000
E27.1 Primary adrenocortical insufficiency
0.825 0.175 0.000
E10.8 With unspecified complications
0.824 0.176 0.000
E10.7 With multiple complications
0.824 0.176 0.000
K40.3 Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
0.000 0.177 0.823
E14.6 With other specified complications
0.823 0.177 0.000
E11 Non-insulin-dependent diabetes mellitus
0.815 0.185 0.000
E14.5 With peripheral circulatory complications
0.811 0.189 0.000
E14.1 With ketoacidosis
0.803 0.197 0.000
E11.5 With peripheral circulatory complications
0.802 0.198 0.000
K44.0 Diaphragmatic hernia with obstruction, without gangrene
0.000 0.210 0.790
E03.8 Other specified hypothyroidism
0.769 0.231 0.000
K40.0 Bilateral inguinal hernia, with obstruction, without gangrene
0.000 0.232 0.768
E16.1 Other hypoglycaemia
0.764 0.236 0.000
K45 Other abdominal hernia
0.000 0.238 0.762
E14.2 Withrenal complications
0.761 0.239 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.756 0.244 0.000
E11.6 With other specified complications
0.748 0.252 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.732 0.268 0.000
E10.0 With coma
0.730 0.270 0.000
E61 Deficiency of other nutrient elements
0.729 0.271 0.000
E13 Other specified diabetes mellitus
0.728 0.272 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.715 0.285 0.000
E03.5 Myxoedema coma
0.715 0.285 0.000
E03.4 Atrophy of thyroid (acquired)
0.715 0.285 0.000
E03.3 Postinfectious hypothyroidism
0.715 0.285 0.000
E03.1 Congenital hypothyroidism without goitre
0.715 0.285 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.715 0.285 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.714 0.286 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.714 0.286 0.000
E16.4 Abnormal secretion of gastrin
0.714 0.286 0.000
E16.3 Increased secretion of glucagon
0.714 0.286 0.000
E46 Unspecified protein-energy malnutrition
0.710 0.290 0.000
E14.7 With multiple complications
0.708 0.292 0.000
E14.0 With coma
0.708 0.292 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.706 0.294 0.000
K44.1 Diaphragmatic hernia with gangrene
0.000 0.300 0.700
K40.1 Bilateral inguinal hernia, with gangrene
0.000 0.304 0.696
E14.8 With unspecified complications
0.686 0.314 0.000
K90.3 Pancreatic steatorrhoea
0.685 0.315 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.685 0.315 0.000
K90.1 Tropical sprue
0.685 0.315 0.000
E07.8 Other specified disorders of thyroid
0.683 0.316 0.000
E14.4 With neurological complications
0.679 0.321 0.000
E31 Polyglandular dysfunction
0.673 0.327 0.000
E10.4 With neurological complications
0.666 0.334 0.000
E10.6 With other specified complications
0.664 0.336 0.000
E61.1 Iron deficiency
0.656 0.344 0.000
E07.9 Disorder of thyroid, unspecified
0.649 0.351 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.649 0.351 0.000
K45.8 Other specified abdominal hernia without obstruction or gangrene
0.000 0.365 0.635
E25 Adrenogenital disorders
0.632 0.368 0.000
E27.2 Addisonian crisis
0.631 0.369 0.000
K40.4 Unilateral or unspecified inguinal hernia, with gangrene
0.000 0.376 0.623
E22 Hyperfunction of pituitary gland
0.617 0.383 0.000
E56 Other vitamin deficiencies
0.616 0.384 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.608 0.391 0.000
E32 Diseases of thymus
0.608 0.391 0.000
E30 Disorders of puberty, not elsewhere classified
0.608 0.391 0.000
E55 Vitamin D deficiency
0.607 0.392 0.000
E20 Hypoparathyroidism
0.600 0.399 0.000
E27.5 Adrenomedullary hyperfunction
0.599 0.401 0.000
E27.0 Other adrenocortical overactivity
0.599 0.401 0.000
E07.1 Dyshormogenetic goitre
0.598 0.401 0.000
E07.0 Hypersecretion of calcitonin
0.598 0.401 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.596 0.404 0.000
E45 Retarded development following protein-energy malnutrition
0.596 0.404 0.000
E43 Unspecified severe protein-energy malnutrition
0.596 0.404 0.000
E42 Marasmic kwashiorkor
0.596 0.404 0.000
E41 Nutritional marasmus
0.596 0.404 0.000
E40 Kwashiorkor
0.596 0.404 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.595 0.405 0.000
E63 Other nutritional deficiencies
0.595 0.405 0.000
E50 Vitamin A deficiency
0.595 0.405 0.000
E60 Dietary zinc deficiency
0.595 0.405 0.000
E59 Dietary selenium deficiency
0.595 0.405 0.000
E58 Dietary calcium deficiency
0.595 0.405 0.000
E54 Ascorbic acid deficiency
0.595 0.405 0.000
E52 Niacin deficiency [pellagra]
0.595 0.405 0.000
E51 Thiamine deficiency
0.592 0.408 0.000
E26 Hyperaldosteronism
0.585 0.415 0.000
E11.7 With multiple complications
0.585 0.415 0.000
E11.3 With ophthalmic complications
0.582 0.418 0.000
E05.8 Other thyrotoxicosis
0.567 0.432 0.000
E24 Cushing's syndrome
0.564 0.436 0.000
E11.2 With renal complications
0.557 0.443 0.000
E31.0 Autoimmune polyglandular failure
0.547 0.453 0.000
K45.1 Other specified abdominal hernia with gangrene
0.000 0.454 0.546
K90.8 Other intestinal malabsorption
0.538 0.462 0.000
E22.1 Hyperprolactinaemia
0.538 0.462 0.000
E13.9 Without complications
0.533 0.466 0.000
E06 Thyroiditis
0.529 0.470 0.000
E61.2 Magnesium deficiency
0.528 0.472 0.000
E61.9 Deficiency of nutrient element, unspecified
0.523 0.477 0.000
E61.8 Deficiency of other specified nutrient elements
0.523 0.477 0.000
E61.7 Deficiency of multiple nutrient elements
0.523 0.477 0.000
E61.6 Vanadium deficiency
0.523 0.477 0.000
E61.5 Molybdenum deficiency
0.523 0.477 0.000
E61.4 Chromium deficiency
0.523 0.477 0.000
E61.3 Manganese deficiency
0.523 0.477 0.000
E61.0 Copper deficiency
0.523 0.477 0.000
E13.8 With unspecified complications
0.522 0.478 0.000
E13.7 With multiple complications
0.522 0.478 0.000
E13.6 With other specified complications
0.522 0.478 0.000
E13.5 With peripheral circulatory complications
0.522 0.478 0.000
E13.4 With neurological complications
0.522 0.478 0.000
E13.3 With ophthalmic complications
0.522 0.478 0.000
E13.2 With renal complications
0.522 0.478 0.000
E13.1 With ketoacidosis
0.522 0.478 0.000
E13.0 With coma
0.522 0.478 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.521 0.479 0.000
K45.0 Other specified abdominal hernia with obstruction, without gangrene
0.000 0.481 0.518
E28 Ovarian dysfunction
0.518 0.482 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.514 0.486 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.514 0.486 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.514 0.486 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.514 0.486 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.514 0.486 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.514 0.486 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.514 0.486 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.514 0.486 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
E53 Deficiency of other B group vitamins
0.502 0.498 0.000
E31.9 Polyglandular dysfunction, unspecified
0.482 0.517 0.000
E31.8 Other polyglandular dysfunction
0.482 0.517 0.000
E31.1 Polyglandular hyperfunction
0.482 0.517 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.477 0.523 0.000
E24.2 Drug-induced Cushing's syndrome
0.472 0.527 0.000
E11.0 With coma
0.470 0.530 0.000
E27.9 Disorder of adrenal gland, unspecified
0.464 0.535 0.000
E56.1 Deficiency of vitamin K
0.462 0.537 0.000
E34 Other endocrine disorders
0.458 0.542 0.000
E25.9 Adrenogenital disorder, unspecified
0.453 0.547 0.000
E25.8 Other adrenogenital disorders
0.453 0.547 0.000
E11.8 With unspecified complications
0.450 0.550 0.000
E55.9 Vitamin D deficiency, unspecified
0.448 0.552 0.000
E23 Hypofunction and other disorders of pituitary gland
0.445 0.555 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.442 0.557 0.000
E22.8 Other hyperfunction of pituitary gland
0.442 0.557 0.000
E56.9 Vitamin deficiency, unspecified
0.441 0.558 0.000
E56.8 Deficiency of other vitamins
0.441 0.558 0.000
E56.0 Deficiency of vitamin E
0.441 0.558 0.000
E30.9 Disorder of puberty, unspecified
0.436 0.564 0.000
E30.8 Other disorders of puberty
0.436 0.564 0.000
E30.1 Precocious puberty
0.436 0.564 0.000
E30.0 Delayed puberty
0.436 0.564 0.000
E32.9 Disease of thymus, unspecified
0.436 0.564 0.000
E32.8 Other diseases of thymus
0.436 0.564 0.000
E32.1 Abscess of thymus
0.436 0.564 0.000
E32.0 Persistent hyperplasia of thymus
0.436 0.564 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.436 0.564 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.436 0.564 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.436 0.564 0.000
E55.0 Rickets, active
0.436 0.564 0.000
E11.1 With ketoacidosis
0.433 0.566 0.000
K41 Femoral hernia
0.000 0.568 0.432
E20.8 Other hypoparathyroidism
0.431 0.569 0.000
E20.1 Pseudohypoparathyroidism
0.431 0.569 0.000
E20.0 Idiopathic hypoparathyroidism
0.431 0.569 0.000
E29 Testicular dysfunction
0.429 0.571 0.001
E44.1 Mild protein-energy malnutrition
0.427 0.573 0.000
E44.0 Moderate protein-energy malnutrition
0.427 0.573 0.000
E50.9 Vitamin A deficiency, unspecified
0.426 0.573 0.000
E50.8 Other manifestations of vitamin A deficiency
0.426 0.573 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.426 0.573 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.426 0.573 0.000
E50.5 Vitamin A deficiency with night blindness
0.426 0.573 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.426 0.573 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.426 0.573 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.426 0.573 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.426 0.573 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.426 0.573 0.000
E63.9 Nutritional deficiency, unspecified
0.426 0.573 0.000
E63.8 Other specified nutritional deficiencies
0.426 0.573 0.000
E63.1 Imbalance of constituents of food intake
0.426 0.573 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.426 0.573 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.426 0.573 0.000
E64.8 Sequelae of other nutritional deficiencies
0.426 0.573 0.000
E64.3 Sequelae of rickets
0.426 0.573 0.000
E64.2 Sequelae of vitamin C deficiency
0.426 0.573 0.000
E64.1 Sequelae of vitamin A deficiency
0.426 0.573 0.000
E64.0 Sequelae of protein-energy malnutrition
0.426 0.573 0.000
E51.9 Thiamine deficiency, unspecified
0.425 0.575 0.000
E51.8 Other manifestations of thiamine deficiency
0.425 0.575 0.000
E51.1 Beriberi
0.425 0.575 0.000
E20.9 Hypoparathyroidism, unspecified
0.423 0.577 0.000
E51.2 Wernicke's encephalopathy
0.422 0.578 0.000
E26.9 Hyperaldosteronism, unspecified
0.419 0.580 0.000
E26.8 Other hyperaldosteronism
0.419 0.580 0.000
E26.1 Secondary hyperaldosteronism
0.419 0.580 0.000
E24.0 Pituitary-dependent Cushing's disease
0.414 0.585 0.000
E21.0 Primary hyperparathyroidism
0.410 0.590 0.000
E24.8 Other Cushing's syndrome
0.404 0.595 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.404 0.595 0.000
E24.3 Ectopic ACTH syndrome
0.404 0.595 0.000
E24.1 Nelson's syndrome
0.404 0.595 0.000
K46 Unspecified abdominal hernia
0.000 0.598 0.401
E26.0 Primary hyperaldosteronism
0.396 0.604 0.000
E22.0 Acromegaly and pituitary gigantism
0.390 0.610 0.000
E06.5 Other chronic thyroiditis
0.380 0.620 0.000
E06.4 Drug-induced thyroiditis
0.380 0.620 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.380 0.620 0.000
E06.1 Subacute thyroiditis
0.380 0.620 0.000
E06.0 Acute thyroiditis
0.380 0.620 0.000
E53.9 Vitamin B deficiency, unspecified
0.376 0.624 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.373 0.626 0.000
E21.4 Other specified disorders of parathyroid gland
0.373 0.626 0.000
E21.2 Other hyperparathyroidism
0.373 0.626 0.000
E28.9 Ovarian dysfunction, unspecified
0.371 0.628 0.000
E28.8 Other ovarian dysfunction
0.371 0.628 0.000
E28.1 Androgen excess
0.371 0.628 0.000
E28.0 Oestrogen excess
0.371 0.628 0.000
E65-E68 Obesity and other hyperalimentation
0.370 0.630 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.362 0.637 0.001
E53.1 Pyridoxine deficiency
0.360 0.640 0.000
E53.0 Riboflavin deficiency
0.360 0.640 0.000
K42 Umbilical hernia
0.000 0.640 0.360
E28.3 Primary ovarian failure
0.356 0.644 0.000
E06.9 Thyroiditis, unspecified
0.351 0.649 0.000
E23.2 Diabetes insipidus
0.351 0.649 0.000
E27.8 Other specified disorders of adrenal gland
0.347 0.652 0.001
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.337 0.663 0.000
E34.8 Other specified endocrine disorders
0.330 0.669 0.000
E34.5 Androgen resistance syndrome
0.328 0.672 0.000
E34.4 Constitutional tall stature
0.328 0.672 0.000
E34.3 Short stature, not elsewhere classified
0.328 0.672 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.328 0.672 0.000
E34.1 Other hypersecretion of intestinal hormones
0.328 0.672 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.319 0.681 0.000
E23.1 Drug-induced hypopituitarism
0.319 0.681 0.000
T39.1 4-Aminophenol derivatives
0.000 0.681 0.319
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.311 0.689 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.689 0.311
T42.4 Benzodiazepines
0.000 0.689 0.311
K41.4 Unilateral or unspecified femoral hernia, with gangrene
0.000 0.690 0.310
K41.2 Bilateral femoral hernia, without obstruction or gangrene
0.000 0.690 0.310
K41.1 Bilateral femoral hernia, with gangrene
0.000 0.690 0.310
K41.0 Bilateral femoral hernia, with obstruction, without gangrene
0.000 0.690 0.310
E23.6 Other disorders of pituitary gland
0.308 0.691 0.000
E29.9 Testicular dysfunction, unspecified
0.307 0.692 0.001
E29.8 Other testicular dysfunction
0.307 0.692 0.001
E29.0 Testicular hyperfunction
0.307 0.692 0.001
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.694 0.306
E28.2 Polycystic ovarian syndrome
0.304 0.696 0.000
E21.3 Hyperparathyroidism, unspecified
0.301 0.699 0.000
E34.9 Endocrine disorder, unspecified
0.297 0.703 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.000 0.703 0.297
K46.1 Unspecified abdominal hernia with gangrene
0.000 0.712 0.288
E23.7 Disorder of pituitary gland, unspecified
0.287 0.712 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.000 0.713 0.287
K43 Ventral hernia
0.000 0.719 0.281
K41.3 Unilateral or unspecified femoral hernia, with obstruction, without gangrene
0.000 0.720 0.279
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.000 0.734 0.266
E67 Other hyperalimentation
0.265 0.735 0.000
E68 Sequelae of hyperalimentation
0.265 0.735 0.000
E04 Other non-toxic goitre
0.259 0.741 0.000
T39.0 Salicylates
0.000 0.741 0.259
K42.1 Umbilical hernia with gangrene
0.000 0.742 0.258
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.000 0.748 0.252
E11.4 With neurological complications
0.249 0.751 0.000
E06.3 Autoimmune thyroiditis
0.246 0.754 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.755 0.245
E53.8 Deficiency of other specified B group vitamins
0.238 0.762 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.000 0.765 0.235
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.000 0.765 0.235
K40.2 Bilateral inguinal hernia, without obstruction or gangrene
0.000 0.767 0.233
K42.0 Umbilical hernia with obstruction, without gangrene
0.000 0.769 0.231
T42.0 Hydantoin derivatives
0.000 0.771 0.229
T42.1 Iminostilbenes
0.000 0.772 0.228
I77.1 Stricture of artery
0.228 0.772 0.000
E34.0 Carcinoid syndrome
0.227 0.772 0.001
E65 Localised adiposity
0.226 0.774 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.000 0.774 0.226
I77 Other disorders of arteries and arterioles
0.225 0.775 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.225 0.775 0.000
K46.0 Unspecified abdominal hernia with obstruction, without gangrene
0.001 0.775 0.224
I73 Other peripheral vascular diseases
0.224 0.776 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.000 0.777 0.223
T42.5 Mixed antiepileptics, not elsewhere classified
0.000 0.777 0.223
T42.3 Barbiturates
0.000 0.777 0.223
T42.2 Succinimides and oxazolidinediones
0.000 0.777 0.223
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.000 0.778 0.221
T39.4 Antirheumatics, not elsewhere classified
0.000 0.780 0.219
T39.2 Pyrazolone derivatives
0.000 0.780 0.219
I73.9 Peripheral vascular disease, unspecified
0.219 0.781 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.000 0.781 0.219
I74 Arterial embolism and thrombosis
0.215 0.785 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.000 0.787 0.213
T41 Poisoning by anaesthetics and therapeutic gases
0.000 0.787 0.213
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.213 0.787 0.000
T36 Poisoning by systemic antibiotics
0.000 0.790 0.210
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.000 0.793 0.207
E04.9 Non-toxic goitre, unspecified
0.207 0.793 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.205 0.795 0.000
K43.7 Other and unspecified ventral hernia with gangrene
0.000 0.798 0.202
K43.6 Other and unspecified ventral hernia with obstruction, without gangrene
0.000 0.798 0.202
K43.5 Parastomal hernia without obstruction or gangrene
0.000 0.798 0.202
K43.4 Parastomal hernia with gangrene
0.000 0.798 0.202
K43.3 Parastomal hernia with obstruction, without gangrene
0.000 0.798 0.202
K43.2 Incisional hernia without obstruction or gangrene
0.000 0.798 0.202
K43.1 Ventral hernia with gangrene
0.000 0.798 0.202
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.000 0.798 0.202
E83 Disorders of mineral metabolism
0.152 0.799 0.049
I73.0 Raynaud's syndrome
0.199 0.801 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.198 0.802 0.000
T40.2 Other opioids
0.000 0.803 0.197
I74.5 Embolism and thrombosis of iliac artery
0.193 0.807 0.000
T50.8 Diagnostic agents
0.000 0.809 0.191
T50.7 Analeptics and opioid receptor antagonists
0.000 0.809 0.191
T50.5 Appetite depressants
0.000 0.809 0.191
T50.4 Drugs affecting uric acid metabolism
0.000 0.809 0.191
T50.3 Electrolytic, caloric and water-balance agents
0.000 0.809 0.191
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.000 0.809 0.191
T50.1 Loop [high-ceiling] diuretics
0.000 0.809 0.191
T50.0 Mineralocorticoids and their antagonists
0.000 0.809 0.191
E67.8 Other specified hyperalimentation
0.190 0.810 0.000
E67.3 Hypervitaminosis D
0.190 0.810 0.000
E67.2 Megavitamin-B6 syndrome
0.190 0.810 0.000
E67.1 Hypercarotenaemia
0.190 0.810 0.000
E67.0 Hypervitaminosis A
0.190 0.810 0.000
I77.8 Other specified disorders of arteries and arterioles
0.189 0.811 0.000
I77.6 Arteritis, unspecified
0.188 0.812 0.000
E04.8 Other specified non-toxic goitre
0.186 0.814 0.000
E24.9 Cushing's syndrome, unspecified
0.182 0.816 0.001
T50.6 Antidotes and chelating agents, not elsewhere classified
0.000 0.816 0.184
I77.2 Rupture of artery
0.178 0.822 0.000
I70 Atherosclerosis
0.175 0.825 0.000
I74.8 Embolism and thrombosis of other arteries
0.174 0.826 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.169 0.831 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.000 0.832 0.168
T40.8 Lysergide [LSD]
0.000 0.832 0.168
T40.7 Cannabis (derivatives)
0.000 0.832 0.168
T40.5 Cocaine
0.000 0.832 0.168
T40.3 Methadone
0.000 0.832 0.168
T40.1 Heroin
0.000 0.832 0.168
T40.0 Opium
0.000 0.832 0.168
E70-E90 Metabolic disorders
0.167 0.832 0.001
T47.1 Other antacids and anti-gastric-secretion drugs
0.000 0.833 0.167
T46 Poisoning by agents primarily affecting the cardiovascular system
0.000 0.834 0.166
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.000 0.835 0.165
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.164 0.836 0.000
T40.6 Other and unspecified narcotics
0.000 0.837 0.163
I77.5 Necrosis of artery
0.162 0.838 0.000
I77.4 Coeliac artery compression syndrome
0.162 0.838 0.000
I77.3 Arterial fibromuscular dysplasia
0.162 0.838 0.000
T40.4 Other synthetic narcotics
0.000 0.839 0.161
E23.0 Hypopituitarism
0.159 0.840 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.159 0.840 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.000 0.841 0.159
T47.8 Other agents primarily affecting the gastro-intestinal system
0.000 0.841 0.159
T47.7 Emetics
0.000 0.841 0.159
T47.6 Antidiarrhoeal drugs
0.000 0.841 0.159
T47.5 Digestants
0.000 0.841 0.159
T47.4 Other laxatives
0.000 0.841 0.159
T47.3 Saline and osmotic laxatives
0.000 0.841 0.159
T47.2 Stimulant laxatives
0.000 0.841 0.159
T47.0 Histamine H(2)-receptor antagonists
0.000 0.841 0.159
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.842 0.158
T38.9 Other and unspecified hormone antagonists
0.000 0.843 0.157
T38.8 Other and unspecified hormones and their synthetic substitutes
0.000 0.843 0.157
T38.7 Androgens and anabolic congeners
0.000 0.843 0.157
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.000 0.843 0.157
T38.5 Other oestrogens and progestogens
0.000 0.843 0.157
T38.4 Oral contraceptives
0.000 0.843 0.157
T38.2 Antithyroid drugs
0.000 0.843 0.157
T38.0 Glucocorticoids and synthetic analogues
0.000 0.843 0.157
E80 Disorders of porphyrin and bilirubin metabolism
0.155 0.845 0.000
T38.1 Thyroid hormones and substitutes
0.000 0.845 0.155
T41.5 Therapeutic gases
0.000 0.847 0.153
T41.4 Anaesthetic, unspecified
0.000 0.847 0.153
T41.3 Local anaesthetics
0.000 0.847 0.153
T41.2 Other and unspecified general anaesthetics
0.000 0.847 0.153
T41.1 Intravenous anaesthetics
0.000 0.847 0.153
T41.0 Inhaled anaesthetics
0.000 0.847 0.153
T49.9 Topical agent, unspecified
0.000 0.847 0.153
T49.8 Other topical agents
0.000 0.847 0.153
T49.7 Dental drugs, topically applied
0.000 0.847 0.153
T49.6 Otorhinolaryngological drugs and preparations
0.000 0.847 0.153
T49.5 Ophthalmological drugs and preparations
0.000 0.847 0.153
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.000 0.847 0.153
T49.3 Emollients, demulcents and protectants
0.000 0.847 0.153
T49.2 Local astringents and local detergents
0.000 0.847 0.153
T49.1 Antipruritics
0.000 0.847 0.153
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.000 0.847 0.153
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.153 0.847 0.000
I79.1 Aortitis in diseases classified elsewhere
0.153 0.847 0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.153 0.847 0.000
E04.0 Non-toxic diffuse goitre
0.152 0.847 0.000
I70.8 Atherosclerosis of other arteries
0.152 0.848 0.000
T36.9 Systemic antibiotic, unspecified
0.000 0.849 0.151
T36.8 Other systemic antibiotics
0.000 0.849 0.151
T36.7 Antifungal antibiotics, systemically used
0.000 0.849 0.151
T36.6 Rifamycins
0.000 0.849 0.151
T36.5 Aminoglycosides
0.000 0.849 0.151
T36.4 Tetracyclines
0.000 0.849 0.151
T36.3 Macrolides
0.000 0.849 0.151
T36.2 Chloramphenicol group
0.000 0.849 0.151
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.000 0.849 0.151
I78 Diseases of capillaries
0.150 0.850 0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.000 0.851 0.149
T37.5 Antiviral drugs
0.000 0.851 0.149
T37.4 Anthelminthics
0.000 0.851 0.149
T37.3 Other antiprotozoal drugs
0.000 0.851 0.149
T37.2 Antimalarials and drugs acting on other blood protozoa
0.000 0.851 0.149
T37.1 Antimycobacterial drugs
0.000 0.851 0.149
T37.0 Sulphonamides
0.000 0.851 0.149
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.148 0.852 0.000
E83.5 Disorders of calcium metabolism
0.146 0.852 0.001
T36.0 Penicillins
0.000 0.852 0.147
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.000 0.853 0.147
I73.8 Other specified peripheral vascular diseases
0.146 0.854 0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.000 0.855 0.145
T48.5 Anti-common-cold drugs
0.000 0.855 0.145
T48.4 Expectorants
0.000 0.855 0.145
T48.3 Antitussives
0.000 0.855 0.145
T48.2 Other and unspecified agents primarily acting on muscles
0.000 0.855 0.145
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.000 0.855 0.145
T48.0 Oxytocic drugs
0.000 0.855 0.145
K46.9 Unspecified abdominal hernia without obstruction or gangrene
0.001 0.856 0.144
E83.9 Disorder of mineral metabolism, unspecified
0.109 0.856 0.035
E83.8 Other disorders of mineral metabolism
0.109 0.856 0.035
E83.2 Disorders of zinc metabolism
0.109 0.856 0.035
E83.0 Disorders of copper metabolism
0.109 0.856 0.035
I74.0 Embolism and thrombosis of abdominal aorta
0.144 0.856 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.000 0.857 0.143
E80.4 Gilbert's syndrome
0.143 0.857 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.000 0.858 0.141
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.861 0.139
N40-N51 Diseases of male genital organs
0.000 0.863 0.137
I70.80 Atherosclerosis of other arteries (without gangrene)
0.135 0.865 0.000
T48.6 Antiasthmatics, not elsewhere classified
0.000 0.867 0.133
E70 Disorders of aromatic amino-acid metabolism
0.131 0.868 0.001
N41 Inflammatory diseases of prostate
0.000 0.871 0.129
E29.1 Testicular hypofunction
0.127 0.871 0.001
K41.9 Unilateral or unspecified femoral hernia, without obstruction or gangrene
0.000 0.872 0.128
E84 Cystic fibrosis
0.127 0.873 0.001
E80.2 Other porphyria
0.127 0.873 0.000
I70.9 Generalised and unspecified atherosclerosis
0.126 0.874 0.000
E83.4 Disorders of magnesium metabolism
0.110 0.877 0.013
T46.4 Angiotensin-converting-enzyme inhibitors
0.000 0.877 0.123
I70.0 Atherosclerosis of aorta
0.122 0.878 0.000
E77 Disorders of glycoprotein metabolism
0.120 0.879 0.001
E76 Disorders of glycosaminoglycan metabolism
0.120 0.879 0.001
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.120 0.879 0.001
E72 Other disorders of amino-acid metabolism
0.120 0.879 0.001
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.120 0.879 0.001
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.120 0.879 0.001

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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