TreeWAS – Variant ID: rs3891175

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.000	1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
D64.9 Anaemia, unspecified	1.000	0.000	0.000
E03.9 Hypothyroidism, unspecified	1.000	0.000	0.000
E05.9 Thyrotoxicosis, unspecified	1.000	0.000	0.000
E05.0 Thyrotoxicosis with diffuse goitre	1.000	0.000	0.000
E10.9 Without complications	1.000	0.000	0.000
E10.3 With ophthalmic complications	1.000	0.000	0.000
E16.2 Hypoglycaemia, unspecified	1.000	0.000	0.000
K90.0 Coeliac disease	1.000	0.000	0.000
M06.9 Rheumatoid arthritis, unspecified	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	1.000	0.000	0.000
E10-E14 Diabetes mellitus	1.000	0.000	0.000
E00-E07 Disorders of thyroid gland	1.000	0.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	1.000	0.000	0.000
# Top node	1.000	0.000	0.000
E14 Unspecified diabetes mellitus	1.000	0.000	0.000
K90 Intestinal malabsorption	1.000	0.000	0.000
E16 Other disorders of pancreatic internal secretion	1.000	0.000	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
E03 Other hypothyroidism	1.000	0.000	0.000
M06 Other rheumatoid arthritis	0.000	0.000	1.000
J45.9 Asthma, unspecified	1.000	0.000	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	1.000	0.000	0.000
E10.1 With ketoacidosis	1.000	0.000	0.000
N00-N08 Glomerular diseases	1.000	0.000	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.000	0.000	1.000
D64 Other anaemias	1.000	0.000	0.000
D60-D64 Aplastic and other anaemias	1.000	0.000	0.000
E14.3 With ophthalmic complications	1.000	0.000	0.000
N04 Nephrotic syndrome	0.999	0.001	0.000
M05-M14 Inflammatory polyarthropathies	0.003	0.001	0.996
M05 Seropositive rheumatoid arthritis	0.001	0.001	0.997
N04.9 Unspecified	0.998	0.002	0.000
E10.4 With neurological complications	0.998	0.002	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.998	0.002	0.000
Chapter VII Diseases of the eye and adnexa	0.997	0.003	0.000
D69 Purpura and other haemorrhagic conditions	0.997	0.003	0.000
H30-H36 Disorders of choroid and retina	0.997	0.003	0.000
K90.9 Intestinal malabsorption, unspecified	0.997	0.003	0.000
Chapter XI Diseases of the digestive system	0.997	0.003	0.000
K90-K93 Other diseases of the digestive system	0.997	0.003	0.000
H36 Retinal disorders in diseases classified elsewhere	0.997	0.003	0.000
H36.0 Diabetic retinopathy	0.997	0.003	0.000
D69.6 Thrombocytopenia, unspecified	0.996	0.004	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.005	0.995
N05 Unspecified nephritic syndrome	0.995	0.005	0.000
Chapter XIV Diseases of the genitourinary system	0.995	0.005	0.000
K51.9 Ulcerative colitis, unspecified	0.000	0.005	0.995
Chapter XII Diseases of the skin and subcutaneous tissue	0.993	0.007	0.000
D50-D53 Nutritional anaemias	0.992	0.008	0.000
M06.3 Rheumatoid nodule	0.000	0.012	0.988
R31 Unspecified haematuria	0.000	0.012	0.988
G50-G59 Nerve, nerve root and plexus disorders	0.988	0.012	0.000
Chapter VI Diseases of the nervous system	0.987	0.013	0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere	0.986	0.014	0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders	0.985	0.015	0.000
K70-K77 Diseases of liver	0.985	0.015	0.000
N08 Glomerular disorders in diseases classified elsewhere	0.984	0.016	0.000
L10-L14 Bullous disorders	0.982	0.018	0.000
E10.2 With renal complications	0.981	0.019	0.000
N05.2 Diffuse membranous glomerulonephritis	0.979	0.021	0.000
H43-H45 Disorders of vitreous body and globe	0.977	0.023	0.000
L50-L54 Urticaria and erythema	0.976	0.024	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.975	0.025	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.025	0.975
K75 Other inflammatory liver diseases	0.974	0.026	0.000
L13 Other bullous disorders	0.974	0.026	0.000
L40-L45 Papulosquamous disorders	0.972	0.028	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.028	0.972
H43 Disorders of vitreous body	0.969	0.031	0.000
L13.0 Dermatitis herpetiformis	0.969	0.031	0.000
N08.3 Glomerular disorders in diabetes mellitus	0.969	0.031	0.000
L43 Lichen planus	0.968	0.032	0.000
Chapter II Neoplasms	0.967	0.033	0.000
K75.4 Autoimmune hepatitis	0.966	0.034	0.000
K50-K52 Noninfective enteritis and colitis	0.728	0.035	0.238
D51 Vitamin B12 deficiency anaemia	0.965	0.035	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.965	0.035	0.000
K51 Ulcerative colitis	0.001	0.035	0.964
H34 Retinal vascular occlusions	0.964	0.036	0.000
L43.9 Lichen planus, unspecified	0.964	0.036	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.963	0.037	0.000
N50.8 Other specified disorders of male genital organs	0.951	0.049	0.000
N40-N51 Diseases of male genital organs	0.950	0.050	0.000
H43.1 Vitreous haemorrhage	0.948	0.052	0.000
N50 Other disorders of male genital organs	0.948	0.052	0.000
L53 Other erythematous conditions	0.947	0.053	0.000
M06.34 Rheumatoid nodule (Hand)	0.000	0.054	0.946
D50 Iron deficiency anaemia	0.942	0.058	0.000
H34.8 Other retinal vascular occlusions	0.941	0.059	0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.940	0.060	0.000
G59 Mononeuropathy in diseases classified elsewhere	0.939	0.061	0.000
D50.9 Iron deficiency anaemia, unspecified	0.937	0.063	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.936	0.064	0.000
G11 Hereditary ataxia	0.935	0.065	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.935	0.065	0.000
C91 Lymphoid leukaemia	0.934	0.066	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.889	0.068	0.043
D80-D89 Certain disorders involving the immune mechanism	0.929	0.071	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.923	0.077	0.000
L53.9 Erythematous condition, unspecified	0.923	0.077	0.000
E14.9 Without complications	0.921	0.079	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.080	0.920
E11 Non-insulin-dependent diabetes mellitus	0.919	0.081	0.000
H43.8 Other disorders of vitreous body	0.918	0.082	0.000
E13 Other specified diabetes mellitus	0.917	0.083	0.000
K51.4 Pseudopolyposis of colon	0.000	0.085	0.914
M06.0 Seronegative rheumatoid arthritis	0.000	0.086	0.914
E16.0 Drug-induced hypoglycaemia without coma	0.910	0.090	0.000
C85.1 B-cell lymphoma, unspecified	0.910	0.090	0.000
C80.0 Malignant neoplasm, primary site unknown, so stated	0.910	0.090	0.000
H46-H48 Disorders of optic nerve and visual pathways	0.909	0.091	0.000
C80 Malignant neoplasm without specification of site	0.908	0.092	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.908	0.092	0.000
G11.9 Hereditary ataxia, unspecified	0.907	0.093	0.000
K73 Chronic hepatitis, not elsewhere classified	0.907	0.093	0.000
G59.0 Diabetic mononeuropathy	0.905	0.095	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.902	0.098	0.000
E14.8 With unspecified complications	0.901	0.099	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.900	0.100	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.900	0.100	0.000
N17-N19 Renal failure	0.900	0.100	0.000
C15-C26 Malignant neoplasms of digestive organs	0.898	0.102	0.000
M07 Psoriatic and enteropathic arthropathies	0.001	0.104	0.894
L52 Erythema nodosum	0.892	0.108	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.892	0.108	0.000
N18 Chronic renal failure	0.889	0.111	0.000
K40-K46 Hernia	0.889	0.111	0.000
M81.99 Osteoporosis, unspecified (Site unspecified)	0.885	0.115	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.000	0.116	0.884
C20 Malignant neoplasm of rectum	0.882	0.118	0.000
M80-M85 Disorders of bone density and structure	0.876	0.118	0.006
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.882	0.118	0.000
N05.9 Unspecified	0.881	0.119	0.000
K43 Ventral hernia	0.872	0.128	0.000
M81 Osteoporosis without pathological fracture	0.869	0.128	0.003
E11.5 With peripheral circulatory complications	0.872	0.128	0.000
K75.8 Other specified inflammatory liver diseases	0.872	0.128	0.000
C91.1 Chronic lymphocytic leukaemia	0.872	0.128	0.000
K43.0 Ventral hernia with obstruction, without gangrene	0.869	0.131	0.000
M81.9 Osteoporosis, unspecified	0.868	0.131	0.001
N25-N29 Other disorders of kidney and ureter	0.869	0.131	0.000
D69.2 Other nonthrombocytopenic purpura	0.869	0.131	0.000
G56 Mononeuropathies of upper limb	0.868	0.132	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.864	0.136	0.000
D70 Agranulocytosis	0.862	0.138	0.000
M20-M25 Other joint disorders	0.824	0.139	0.038
K51.3 Ulcerative (chronic) rectosigmoiditis	0.000	0.140	0.860
E40-E46 Malnutrition	0.858	0.141	0.000
E10.0 With coma	0.856	0.144	0.000
N18.9 Chronic renal failure, unspecified	0.855	0.145	0.000
E13.9 Without complications	0.854	0.146	0.000
D80 Immunodeficiency with predominantly antibody defects	0.853	0.147	0.000
G55.2 Nerve root and plexus compressions in spondylosis	0.852	0.148	0.000
D69.9 Haemorrhagic condition, unspecified	0.851	0.149	0.000
Q50-Q56 Congenital malformations of genital organs	0.850	0.150	0.000
N18.4 Chronic kidney disease, stage 4	0.848	0.152	0.000
M35 Other systemic involvement of connective tissue	0.808	0.154	0.037
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.845	0.155	0.000
E16.1 Other hypoglycaemia	0.845	0.155	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.845	0.155	0.000
G56.0 Carpal tunnel syndrome	0.844	0.156	0.000
C83.3 Large cell (diffuse)	0.843	0.157	0.000
C34 Malignant neoplasm of bronchus and lung	0.839	0.161	0.000
K73.2 Chronic active hepatitis, not elsewhere classified	0.838	0.162	0.000
D69.8 Other specified haemorrhagic conditions	0.837	0.163	0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis	0.836	0.164	0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.835	0.165	0.000
H47 Other disorders of optic [2nd] nerve and visual pathways	0.834	0.166	0.000
G51 Facial nerve disorders	0.831	0.169	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.000	0.169	0.831
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.000	0.171	0.829
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.829	0.171	0.000
N18.0 End-stage renal disease	0.829	0.171	0.000
E14.2 Withrenal complications	0.829	0.171	0.000
C15 Malignant neoplasm of oesophagus	0.823	0.177	0.000
M07.3 Other psoriatic arthropathies	0.000	0.178	0.821
J45 Asthma	0.821	0.179	0.000
D69.4 Other primary thrombocytopenia	0.821	0.179	0.000
N48 Other disorders of penis	0.817	0.183	0.000
C23 Malignant neoplasm of gallbladder	0.817	0.183	0.000
K51.5 Mucosal proctocolitis	0.000	0.186	0.814
M35.0 Sicca syndrome [Sjogren]	0.813	0.186	0.001
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.812	0.188	0.000
Q44.6 Cystic disease of liver	0.812	0.188	0.000
E14.1 With ketoacidosis	0.811	0.189	0.000
C91.0 Acute lymphoblastic leukaemia	0.811	0.189	0.000
E10.6 With other specified complications	0.809	0.191	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.192	0.808
C50-C50 Malignant neoplasm of breast	0.808	0.192	0.000
C38 Malignant neoplasm of heart, mediastinum and pleura	0.808	0.192	0.000
K74 Fibrosis and cirrhosis of liver	0.806	0.194	0.000
C34.3 Lower lobe, bronchus or lung	0.802	0.198	0.000
C32 Malignant neoplasm of larynx	0.800	0.200	0.000
N05.1 Focal and segmental glomerular lesions	0.800	0.200	0.000
N04.2 Diffuse membranous glomerulonephritis	0.796	0.203	0.000
C45 Mesothelioma	0.794	0.206	0.000
G00 Bacterial meningitis, not elsewhere classified	0.793	0.207	0.000
N04.1 Focal and segmental glomerular lesions	0.793	0.207	0.000
C15.4 Middle third of oesophagus	0.792	0.208	0.000
E20-E35 Disorders of other endocrine glands	0.792	0.208	0.000
L44 Other papulosquamous disorders	0.791	0.209	0.000
G70-G73 Diseases of myoneural junction and muscle	0.790	0.210	0.000
E11.6 With other specified complications	0.789	0.211	0.000
M23 Internal derangement of knee	0.789	0.211	0.000
G12 Spinal muscular atrophy and related syndromes	0.788	0.212	0.000
M23.8 Other internal derangements of knee	0.788	0.212	0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified	0.786	0.214	0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.784	0.216	0.000
N25 Disorders resulting from impaired renal tubular function	0.784	0.216	0.000
G04 Encephalitis, myelitis and encephalomyelitis	0.784	0.216	0.000
N04.0 Minor glomerular abnormality	0.783	0.217	0.000
E14.5 With peripheral circulatory complications	0.782	0.218	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.781	0.219	0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis	0.781	0.219	0.000
H34.1 Central retinal artery occlusion	0.780	0.220	0.000
E14.4 With neurological complications	0.778	0.222	0.000
M60-M63 Disorders of muscles	0.748	0.225	0.027
C91.9 Lymphoid leukaemia, unspecified	0.775	0.225	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.227	0.773
L11 Other acantholytic disorders	0.772	0.228	0.000
C76 Malignant neoplasm of other and ill-defined sites	0.770	0.230	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.000	0.230	0.770
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.770	0.230	0.000
D63.0 Anaemia in neoplastic disease	0.769	0.231	0.000
E10.7 With multiple complications	0.769	0.231	0.000
E10.5 With peripheral circulatory complications	0.769	0.231	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.768	0.232	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.232	0.768
N08.5 Glomerular disorders in systemic connective tissue disorders	0.768	0.232	0.000
K72 Hepatic failure, not elsewhere classified	0.767	0.233	0.000
N00 Acute nephritic syndrome	0.766	0.234	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.235	0.765
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.765	0.235	0.000
G55.3 Nerve root and plexus compressions in other dorsopathies	0.765	0.235	0.000
N45 Orchitis and epididymitis	0.760	0.240	0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.759	0.241	0.000
L53.0 Toxic erythema	0.758	0.242	0.000
E03.8 Other specified hypothyroidism	0.757	0.243	0.000
Q39 Congenital malformations of oesophagus	0.757	0.243	0.000
E46 Unspecified protein-energy malnutrition	0.757	0.243	0.000
M86-M90 Other osteopathies	0.745	0.243	0.012
D83 Common variable immunodeficiency	0.756	0.244	0.000
K90.8 Other intestinal malabsorption	0.755	0.245	0.000
K52 Other non-infective gastro-enteritis and colitis	0.725	0.246	0.028
G11.1 Early-onset cerebellar ataxia	0.753	0.247	0.000
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites	0.752	0.248	0.000
D51.3 Other dietary vitamin B12 deficiency anaemia	0.750	0.250	0.000
H30 Chorioretinal inflammation	0.750	0.250	0.000
E10.8 With unspecified complications	0.749	0.251	0.000
E11.1 With ketoacidosis	0.748	0.252	0.000
C34.2 Middle lobe, bronchus or lung	0.748	0.252	0.000
E27 Other disorders of adrenal gland	0.746	0.254	0.000
N48.6 Balanitis xerotica obliterans	0.744	0.256	0.000
E27.1 Primary adrenocortical insufficiency	0.744	0.256	0.000
M85 Other disorders of bone density and structure	0.741	0.257	0.002
Q44.5 Other congenital malformations of bile ducts	0.742	0.258	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.000	0.258	0.742
K52.8 Other specified non-infective gastro-enteritis and colitis	0.741	0.259	0.001
D53 Other nutritional anaemias	0.739	0.261	0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.738	0.262	0.000
K74.6 Other and unspecified cirrhosis of liver	0.738	0.262	0.000
H31 Other disorders of choroid	0.737	0.263	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.735	0.265	0.000
M81.93 Osteoporosis, unspecified (Forearm)	0.731	0.268	0.001
D72 Other disorders of white blood cells	0.732	0.268	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.732	0.268	0.000
C32.9 Larynx, unspecified	0.731	0.269	0.000
Q68 Other congenital musculoskeletal deformities	0.731	0.269	0.000
Q00-Q07 Congenital malformations of the nervous system	0.729	0.271	0.000
C45.0 Mesothelioma of pleura	0.728	0.272	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.000	0.272	0.728
L43.8 Other lichen planus	0.728	0.272	0.000
M06.30 Rheumatoid nodule (Multiple sites)	0.000	0.272	0.728
C31 Malignant neoplasm of accessory sinuses	0.727	0.273	0.000
G51.9 Disorder of facial nerve, unspecified	0.724	0.276	0.000
Q76 Congenital malformations of spine and bony thorax	0.723	0.277	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.721	0.279	0.000
N50.9 Disorder of male genital organs, unspecified	0.721	0.279	0.000
C33 Malignant neoplasm of trachea	0.720	0.280	0.000
D51.8 Other vitamin B12 deficiency anaemias	0.720	0.280	0.000
Q54 Hypospadias	0.720	0.280	0.000
M12 Other specific arthropathies	0.002	0.281	0.717
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.282	0.718
N28 Other disorders of kidney and ureter, not elsewhere classified	0.717	0.283	0.000
E05.5 Thyroid crisis or storm	0.717	0.283	0.000
E05.4 Thyrotoxicosis factitia	0.717	0.283	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.717	0.283	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.717	0.283	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.717	0.283	0.000
E00 Congenital iodine-deficiency syndrome	0.717	0.283	0.000
E12 Malnutrition-related diabetes mellitus	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
E14.7 With multiple complications	0.717	0.283	0.000
E14.0 With coma	0.717	0.283	0.000
K90.3 Pancreatic steatorrhoea	0.717	0.283	0.000
K90.2 Blind loop syndrome, not elsewhere classified	0.717	0.283	0.000
K90.1 Tropical sprue	0.717	0.283	0.000
E03.5 Myxoedema coma	0.717	0.283	0.000
E03.4 Atrophy of thyroid (acquired)	0.717	0.283	0.000
E03.3 Postinfectious hypothyroidism	0.717	0.283	0.000
E03.1 Congenital hypothyroidism without goitre	0.717	0.283	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.717	0.283	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.717	0.283	0.000
E16.4 Abnormal secretion of gastrin	0.717	0.283	0.000
E16.3 Increased secretion of glucagon	0.717	0.283	0.000
M06.8 Other specified rheumatoid arthritis	0.000	0.283	0.717
M06.2 Rheumatoid bursitis	0.000	0.283	0.717
M06.1 Adult-onset Still's disease	0.000	0.283	0.717
E15 Nondiabetic hypoglycaemic coma	0.717	0.283	0.000
N07 Hereditary nephropathy, not elsewhere classified	0.717	0.283	0.000
N06 Isolated proteinuria with specified morphological lesion	0.717	0.283	0.000
N01 Rapidly progressive nephritic syndrome	0.717	0.283	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.000	0.283	0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.283	0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.000	0.283	0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.000	0.283	0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.000	0.283	0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.283	0.717
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.717	0.283	0.000
D64.4 Congenital dyserythropoietic anaemia	0.717	0.283	0.000
D64.3 Other sideroblastic anaemias	0.717	0.283	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.717	0.283	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.717	0.283	0.000
D64.0 Hereditary sideroblastic anaemia	0.717	0.283	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.717	0.283	0.000
N04.8 Other	0.716	0.284	0.000
N04.7 Diffuse crescentic glomerulonephritis	0.716	0.284	0.000
N04.6 Dense deposit disease	0.716	0.284	0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis	0.716	0.284	0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis	0.716	0.284	0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis	0.716	0.284	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.002	0.284	0.714
M08 Juvenile arthritis	0.002	0.284	0.714
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.001	0.284	0.715
M05.2 Rheumatoid vasculitis	0.001	0.284	0.715
M05.1 Rheumatoid lung disease	0.001	0.284	0.715
M05.0 Felty's syndrome	0.001	0.284	0.715
E07 Other disorders of thyroid	0.715	0.284	0.000
J40-J47 Chronic lower respiratory diseases	0.715	0.285	0.000
D67 Hereditary factor IX deficiency	0.715	0.285	0.000
D69.1 Qualitative platelet defects	0.715	0.285	0.000
H32 Chorioretinal disorders in diseases classified elsewhere	0.715	0.285	0.000
G53 Cranial nerve disorders in diseases classified elsewhere	0.715	0.285	0.000
K93 Disorders of other digestive organs in diseases classified elsewhere	0.715	0.285	0.000
H36.8 Other retinal disorders in diseases classified elsewhere	0.715	0.285	0.000
Q78 Other osteochondrodysplasias	0.714	0.285	0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma	0.714	0.286	0.000
C95 Leukaemia of unspecified cell type	0.714	0.286	0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.714	0.286	0.000
N05.7 Diffuse crescentic glomerulonephritis	0.713	0.286	0.000
N05.6 Dense deposit disease	0.713	0.286	0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis	0.713	0.286	0.000
N05.0 Minor glomerular abnormality	0.713	0.286	0.000
H47.1 Papilloedema, unspecified	0.713	0.286	0.000
Q65 Congenital deformities of hip	0.713	0.287	0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere	0.713	0.287	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.689	0.287	0.024
K71 Toxic liver disease	0.711	0.289	0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.711	0.289	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.000	0.291	0.709
M06.38 Rheumatoid nodule (Other)	0.000	0.291	0.709
M06.36 Rheumatoid nodule (Lower leg)	0.000	0.291	0.709
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.000	0.291	0.709
M06.33 Rheumatoid nodule (Forearm)	0.000	0.291	0.709
M06.31 Rheumatoid nodule (Shoulder region)	0.000	0.291	0.709
M05.8 Other seropositive rheumatoid arthritis	0.001	0.292	0.708
K77 Liver disorders in diseases classified elsewhere	0.706	0.294	0.000
M83 Adult osteomalacia	0.702	0.294	0.004
N08.8 Glomerular disorders in other diseases classified elsewhere	0.705	0.295	0.000
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases	0.705	0.295	0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism	0.705	0.295	0.000
N08.1 Glomerular disorders in neoplastic diseases	0.705	0.295	0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere	0.705	0.295	0.000
G72 Other myopathies	0.705	0.295	0.000
L10 Pemphigus	0.704	0.296	0.000
L14 Bullous disorders in diseases classified elsewhere	0.704	0.296	0.000
K74.0 Hepatic fibrosis	0.701	0.299	0.000
N44 Torsion of testis	0.701	0.299	0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere	0.700	0.300	0.000
L54 Erythema in diseases classified elsewhere	0.700	0.300	0.000
G52 Disorders of other cranial nerves	0.700	0.300	0.000
G56.4 Causalgia	0.699	0.301	0.000
Q35-Q37 Cleft lip and cleft palate	0.699	0.301	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.699	0.301	0.000
K75.2 Nonspecific reactive hepatitis	0.698	0.301	0.000
K75.1 Phlebitis of portal vein	0.698	0.301	0.000
L13.9 Bullous disorder, unspecified	0.698	0.302	0.000
L13.8 Other specified bullous disorders	0.698	0.302	0.000
L13.1 Subcorneal pustular dermatitis	0.698	0.302	0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis	0.698	0.302	0.000
K73.8 Other chronic hepatitis, not elsewhere classified	0.697	0.303	0.000
L41 Parapsoriasis	0.697	0.303	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.697	0.303	0.000
C45.9 Mesothelioma, unspecified	0.696	0.304	0.000
G54 Nerve root and plexus disorders	0.695	0.305	0.000
H43.0 Vitreous prolapse	0.695	0.305	0.000
M23.5 Chronic instability of knee	0.694	0.306	0.000
H43.9 Disorder of vitreous body, unspecified	0.694	0.306	0.000
L43.3 Subacute (active) lichen planus	0.694	0.306	0.000
L43.2 Lichenoid drug reaction	0.694	0.306	0.000
L43.1 Bullous lichen planus	0.694	0.306	0.000
L43.0 Hypertrophic lichen planus	0.694	0.306	0.000
C50 Malignant neoplasm of breast	0.694	0.306	0.000
E50-E64 Other nutritional deficiencies	0.694	0.306	0.000
C76.0 Head, face and neck	0.693	0.307	0.000
N46 Male infertility	0.692	0.307	0.000
D51.2 Transcobalamin II deficiency	0.692	0.308	0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.692	0.308	0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.692	0.308	0.000
C94 Other leukaemias of specified cell type	0.692	0.308	0.000
H46 Optic neuritis	0.692	0.308	0.000
H34.0 Transient retinal artery occlusion	0.691	0.309	0.000
K42 Umbilical hernia	0.691	0.309	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.000	0.309	0.691
N48.0 Leukoplakia of penis	0.690	0.310	0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere	0.690	0.310	0.000
G14 Postpolio syndrome	0.690	0.310	0.000
G10 Huntington's disease	0.690	0.310	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.690	0.310	0.000
K75.3 Granulomatous hepatitis, not elsewhere classified	0.689	0.310	0.000
H43.2 Crystalline deposits in vitreous body	0.687	0.313	0.000
C92 Myeloid leukaemia	0.687	0.313	0.000
C38.4 Pleura	0.686	0.313	0.000
K51.2 Ulcerative (chronic) proctitis	0.000	0.314	0.686
N50.0 Atrophy of testis	0.686	0.314	0.000
J46 Status asthmaticus	0.685	0.315	0.000
K51.1 Ulcerative (chronic) ileocolitis	0.001	0.315	0.684
N49.2 Inflammatory disorders of scrotum	0.685	0.315	0.000
G58 Other mononeuropathies	0.683	0.317	0.000
H47.3 Other disorders of optic disk	0.682	0.318	0.000
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess	0.682	0.318	0.000
N51 Disorders of male genital organs in diseases classified elsewhere	0.681	0.319	0.000
N48.8 Other specified disorders of penis	0.681	0.319	0.000
H47.0 Disorders of optic nerve, not elsewhere classified	0.680	0.320	0.000
L50 Urticaria	0.680	0.320	0.000
L53.3 Other chronic figurate erythema	0.679	0.321	0.000
L53.2 Erythema marginatum	0.679	0.321	0.000
L53.1 Erythema annulare centrifugum	0.679	0.321	0.000
M60 Myositis	0.665	0.322	0.014
D82 Immunodeficiency associated with other major defects	0.678	0.322	0.000
Chapter X Diseases of the respiratory system	0.678	0.322	0.000
G00.1 Pneumococcal meningitis	0.677	0.323	0.000
K72.0 Acute and subacute hepatic failure	0.677	0.323	0.000
M32 Systemic lupus erythematosus	0.653	0.323	0.023
C81 Hodgkin's disease	0.676	0.324	0.000
D72.8 Other specified disorders of white blood cells	0.676	0.324	0.000
D50.1 Sideropenic dysphagia	0.675	0.325	0.000
E14.6 With other specified complications	0.675	0.325	0.000
E13.3 With ophthalmic complications	0.674	0.326	0.000
M33 Dermatopolymyositis	0.654	0.326	0.021
G59.8 Other mononeuropathies in diseases classified elsewhere	0.674	0.326	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.673	0.327	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.673	0.327	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.672	0.328	0.000
Q55 Other congenital malformations of male genital organs	0.672	0.328	0.000
M06.4 Inflammatory polyarthropathy	0.000	0.328	0.672
C86 Other specified types of T/NK-cell lymphoma	0.672	0.328	0.000
K51.8 Other ulcerative colitis	0.000	0.328	0.671
Q42 Congenital absence, atresia and stenosis of large intestine	0.671	0.329	0.000
Q41 Congenital absence, atresia and stenosis of small intestine	0.671	0.329	0.000
G11.8 Other hereditary ataxias	0.671	0.329	0.000
G11.3 Cerebellar ataxia with defective DNA repair	0.671	0.329	0.000
G11.2 Late-onset cerebellar ataxia	0.671	0.329	0.000
G11.0 Congenital nonprogressive ataxia	0.671	0.329	0.000
G51.0 Bell's palsy	0.671	0.329	0.000
G11.4 Hereditary spastic paraplegia	0.670	0.330	0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs	0.670	0.330	0.000
E05.8 Other thyrotoxicosis	0.670	0.330	0.000
C91.8 Mature B-cell leukaemia Burkitt-type	0.669	0.330	0.000
C91.7 Other lymphoid leukaemia	0.669	0.330	0.000
C91.6 Prolymphocytic leukaemia of T-cell type	0.669	0.330	0.000
C91.3 Prolymphocytic leukaemia	0.669	0.330	0.000
C91.2 Subacute lymphocytic leukaemia	0.669	0.330	0.000
N28.1 Cyst of kidney, acquired	0.669	0.331	0.000
Q74 Other congenital malformations of limb(s)	0.668	0.332	0.000
C34.8 Overlapping lesion of bronchus and lung	0.667	0.333	0.000
E11.3 With ophthalmic complications	0.667	0.333	0.000
C41.0 Bones of skull and face	0.666	0.334	0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.666	0.334	0.000
C22.9 Liver, unspecified	0.666	0.334	0.000
D73 Diseases of spleen	0.666	0.334	0.000
D81 Combined immunodeficiencies	0.666	0.334	0.000
C88 Malignant immunoproliferative diseases	0.666	0.334	0.000
M86 Osteomyelitis	0.661	0.334	0.004
Q43 Other congenital malformations of intestine	0.665	0.335	0.000
C80.9 Malignant neoplasm, unspecified	0.664	0.336	0.000
G12.2 Motor neuron disease	0.664	0.336	0.000
C85.0 Lymphosarcoma	0.662	0.338	0.000
L44.0 Pityriasis rubra pilaris	0.660	0.339	0.000
M85.6 Other cyst of bone	0.659	0.340	0.001
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.660	0.340	0.000
E11.7 With multiple complications	0.659	0.341	0.000
Q60-Q64 Congenital malformations of the urinary system	0.659	0.341	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.659	0.341	0.000
Q38.1 Ankyloglossia	0.658	0.342	0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.000	0.342	0.658

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations