TreeWAS – Variant ID: rs396660

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E83.1 Disorders of iron metabolism	0.000	0.000	1.000
K90.0 Coeliac disease	1.000	0.000	0.000
M20-M25 Other joint disorders	0.999	0.001	0.000
M25 Other joint disorders, not elsewhere classified	0.998	0.002	0.000
R31 Unspecified haematuria	0.000	0.002	0.998
M07.3 Other psoriatic arthropathies	0.995	0.005	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.994	0.006	0.000
M07 Psoriatic and enteropathic arthropathies	0.994	0.006	0.000
M05-M14 Inflammatory polyarthropathies	0.992	0.008	0.000
M35 Other systemic involvement of connective tissue	0.992	0.008	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.989	0.011	0.000
M35.0 Sicca syndrome [Sjogren]	0.989	0.011	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.989	0.011	0.000
E05.9 Thyrotoxicosis, unspecified	0.986	0.014	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.986	0.014	0.000
M25.5 Pain in joint	0.985	0.015	0.000
M86-M90 Other osteopathies	0.960	0.040	0.000
M25.56 Pain in joint (Lower leg)	0.959	0.041	0.000
M25.4 Effusion of joint	0.958	0.042	0.000
M25.57 Pain in joint (Ankle and foot)	0.945	0.055	0.000
M07.36 Other psoriatic arthropathies (Lower leg)	0.939	0.061	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.000	0.066	0.934
M89 Other disorders of bone	0.931	0.069	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.927	0.073	0.000
E00-E07 Disorders of thyroid gland	0.923	0.077	0.000
M32 Systemic lupus erythematosus	0.917	0.083	0.000
M35.7 Hypermobility syndrome	0.906	0.094	0.000
M34 Systemic sclerosis	0.904	0.096	0.000
M60-M63 Disorders of muscles	0.903	0.097	0.000
M25.9 Joint disorder, unspecified	0.897	0.103	0.000
M11 Other crystal arthropathies	0.891	0.108	0.000
M25.7 Osteophyte	0.891	0.109	0.000
L40 Psoriasis	0.884	0.116	0.000
L40.5 Arthropathic psoriasis	0.883	0.117	0.000
M25.76 Osteophyte (Lower leg)	0.882	0.118	0.000
L40.9 Psoriasis, unspecified	0.876	0.124	0.000
M25.46 Effusion of joint (Lower leg)	0.874	0.126	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.870	0.130	0.000
M25.47 Effusion of joint (Ankle and foot)	0.870	0.130	0.000
M31 Other necrotising vasculopathies	0.867	0.133	0.000
M25.54 Pain in joint (Hand)	0.865	0.135	0.000
M07.34 Other psoriatic arthropathies (Hand)	0.863	0.137	0.000
E06 Thyroiditis	0.862	0.138	0.000
M32.1 Systemic lupus erythematosus with organ or system involvement	0.859	0.141	0.000
E10-E14 Diabetes mellitus	0.855	0.145	0.000
E10 Insulin-dependent diabetes mellitus	0.850	0.150	0.000
M24 Other specific joint derangements	0.845	0.155	0.000
# Top node	0.836	0.164	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.835	0.165	0.000
M62 Other disorders of muscle	0.832	0.168	0.000
M91-M94 Chondropathies	0.832	0.168	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.831	0.169	0.000
M11.2 Other chondrocalcinosis	0.827	0.173	0.000
E10.1 With ketoacidosis	0.826	0.174	0.000
L40-L45 Papulosquamous disorders	0.826	0.174	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.824	0.176	0.000
M25.53 Pain in joint (Forearm)	0.820	0.180	0.000
M89.5 Osteolysis	0.812	0.188	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.810	0.190	0.000
Chapter V Mental and behavioural disorders	0.807	0.193	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.806	0.194	0.000
M89.9 Disorder of bone, unspecified	0.802	0.198	0.000
E06.9 Thyroiditis, unspecified	0.800	0.200	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.796	0.204	0.000
M89.3 Hypertrophy of bone	0.794	0.206	0.000
M25.58 Pain in joint (Other)	0.793	0.207	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.786	0.214	0.000
D68 Other coagulation defects	0.785	0.215	0.000
M07.31 Other psoriatic arthropathies (Shoulder region)	0.785	0.215	0.000
F02 Dementia in other diseases classified elsewhere	0.783	0.217	0.000
M31.6 Other giant cell arteritis	0.782	0.218	0.000
F03 Unspecified dementia	0.782	0.218	0.000
M08 Juvenile arthritis	0.782	0.218	0.000
M07.38 Other psoriatic arthropathies (Other)	0.781	0.219	0.000
M11.26 Other chondrocalcinosis (Lower leg)	0.781	0.219	0.000
K51 Ulcerative colitis	0.000	0.219	0.781
M62.8 Other specified disorders of muscle	0.781	0.219	0.000
M34.9 Systemic sclerosis, unspecified	0.778	0.222	0.000
D55-D59 Haemolytic anaemias	0.772	0.228	0.000
M25.42 Effusion of joint (Upper arm)	0.770	0.230	0.000
Chapter I Certain infectious and parasitic diseases	0.770	0.230	0.000
M87 Osteonecrosis	0.768	0.232	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.767	0.233	0.000
M65-M68 Disorders of synovium and tendon	0.764	0.236	0.000
M34.1 CR(E)ST syndrome	0.764	0.236	0.000
E05.8 Other thyrotoxicosis	0.762	0.238	0.000
E10.2 With renal complications	0.761	0.239	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.757	0.243	0.000
M07.6 Other enteropathic arthropathies	0.756	0.244	0.000
M10 Gout	0.755	0.245	0.000
D68.8 Other specified coagulation defects	0.754	0.246	0.000
D68.9 Coagulation defect, unspecified	0.754	0.246	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.753	0.247	0.000
B35-B49 Mycoses	0.752	0.248	0.000
M25.96 Joint disorder, unspecified (Lower leg)	0.752	0.248	0.000
B37 Candidiasis	0.749	0.251	0.000
K50.9 Crohn's disease, unspecified	0.000	0.251	0.749
M24.1 Other articular cartilage disorders	0.749	0.251	0.000
K50-K52 Noninfective enteritis and colitis	0.004	0.253	0.744
K50 Crohn's disease [regional enteritis]	0.000	0.254	0.746
E07 Other disorders of thyroid	0.746	0.254	0.000
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.746	0.254	0.000
K51.9 Ulcerative colitis, unspecified	0.000	0.255	0.745
M25.3 Other instability of joint	0.745	0.255	0.000
G37 Other demyelinating diseases of central nervous system	0.742	0.258	0.000
Chapter VI Diseases of the nervous system	0.741	0.259	0.000
G35 Multiple sclerosis	0.741	0.259	0.000
F02.3 Dementia in Parkinson's disease	0.740	0.260	0.000
K51.4 Pseudopolyposis of colon	0.000	0.261	0.739
K51.2 Ulcerative (chronic) proctitis	0.000	0.263	0.737
F01 Vascular dementia	0.737	0.263	0.000
B37.9 Candidiasis, unspecified	0.737	0.263	0.000
M62.82 Other specified disorders of muscle (Upper arm)	0.735	0.265	0.000
M25.43 Effusion of joint (Forearm)	0.735	0.265	0.000
E10.9 Without complications	0.731	0.269	0.000
M25.93 Joint disorder, unspecified (Forearm)	0.731	0.269	0.000
M24.2 Disorder of ligament	0.729	0.271	0.000
M89.55 Osteolysis (Pelvic region and thigh)	0.727	0.273	0.000
F30-F39 Mood [affective] disorders	0.724	0.276	0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.723	0.277	0.000
M25.52 Pain in joint (Upper arm)	0.719	0.281	0.000
M93 Other osteochondropathies	0.718	0.282	0.000
M14 Arthropathies in other diseases classified elsewhere	0.717	0.283	0.000
E10.4 With neurological complications	0.717	0.283	0.000
M25.2 Flail joint	0.716	0.284	0.000
M25.1 Fistula of joint	0.716	0.284	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.715	0.285	0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.713	0.286	0.000
M07.33 Other psoriatic arthropathies (Forearm)	0.713	0.286	0.000
M07.32 Other psoriatic arthropathies (Upper arm)	0.713	0.286	0.000
M07.5 Arthropathy in ulcerative colitis	0.712	0.288	0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.712	0.288	0.000
M07.2 Psoriatic spondylitis	0.712	0.288	0.000
M07.1 Arthritis mutilans	0.712	0.288	0.000
M07.0 Distal interphalangeal psoriatic arthropathy	0.712	0.288	0.000
M89.0 Algoneurodystrophy	0.712	0.288	0.000
D70 Agranulocytosis	0.712	0.288	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.712	0.288	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.711	0.289	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.711	0.289	0.000
M35.5 Multifocal fibrosclerosis	0.711	0.289	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.711	0.289	0.000
E05.5 Thyroid crisis or storm	0.709	0.291	0.000
E05.4 Thyrotoxicosis factitia	0.709	0.291	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.709	0.291	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.709	0.291	0.000
M25.45 Effusion of joint (Pelvic region and thigh)	0.707	0.293	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.706	0.294	0.000
G30-G32 Other degenerative diseases of the nervous system	0.703	0.297	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.703	0.297	0.000
F31 Bipolar affective disorder	0.702	0.298	0.000
M25.99 Joint disorder, unspecified (Site unspecified)	0.700	0.300	0.000
M00-M03 Infectious arthropathies	0.699	0.301	0.000
L40.0 Psoriasis vulgaris	0.698	0.302	0.000
M30 Polyarteritis nodosa and related conditions	0.698	0.302	0.000
M35.2 Behcet's disease	0.697	0.303	0.000
M33 Dermatopolymyositis	0.697	0.303	0.000
M25.44 Effusion of joint (Hand)	0.695	0.305	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.694	0.306	0.000
L40.1 Generalised pustular psoriasis	0.692	0.308	0.000
M12 Other specific arthropathies	0.691	0.309	0.000
M25.74 Osteophyte (Hand)	0.691	0.309	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.691	0.309	0.000
M35.1 Other overlap syndromes	0.691	0.309	0.000
M89.8 Other specified disorders of bone	0.690	0.310	0.000
F02.8 Dementia in other specified diseases classified elsewhere	0.689	0.311	0.000
M87.2 Osteonecrosis due to previous trauma	0.688	0.312	0.000
M25.49 Effusion of joint (Site unspecified)	0.687	0.313	0.000
M25.48 Effusion of joint (Other)	0.687	0.313	0.000
D59 Acquired haemolytic anaemia	0.687	0.313	0.000
K51.3 Ulcerative (chronic) rectosigmoiditis	0.000	0.314	0.686
M90 Osteopathies in diseases classified elsewhere	0.685	0.315	0.000
M10.0 Idiopathic gout	0.685	0.315	0.000
D66 Hereditary factor VIII deficiency	0.683	0.317	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.682	0.318	0.000
M24.16 Other articular cartilage disorders (Lower leg)	0.682	0.318	0.000
M89.37 Hypertrophy of bone (Ankle and foot)	0.682	0.318	0.000
F01.9 Vascular dementia, unspecified	0.678	0.322	0.000
M34.8 Other forms of systemic sclerosis	0.677	0.323	0.000
M88 Paget's disease of bone [osteitis deformans]	0.677	0.323	0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.676	0.324	0.000
M67 Other disorders of synovium and tendon	0.675	0.325	0.000
M60 Myositis	0.673	0.327	0.000
M25.73 Osteophyte (Forearm)	0.670	0.330	0.000
K51.0 Ulcerative (chronic) enterocolitis	0.000	0.330	0.670
M91 Juvenile osteochondrosis of hip and pelvis	0.669	0.331	0.000
M25.71 Osteophyte (Shoulder region)	0.668	0.332	0.000
M89.6 Osteopathy after poliomyelitis	0.667	0.332	0.000
M89.2 Other disorders of bone development and growth	0.667	0.332	0.000
M89.1 Epiphyseal arrest	0.667	0.332	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.667	0.333	0.000
M31.1 Thrombotic microangiopathy	0.667	0.333	0.000
M25.41 Effusion of joint (Shoulder region)	0.665	0.335	0.000
B37.8 Candidiasis of other sites	0.664	0.336	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.662	0.338	0.000
E00 Congenital iodine-deficiency syndrome	0.662	0.338	0.000
D73 Diseases of spleen	0.660	0.340	0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.660	0.340	0.000
D58 Other hereditary haemolytic anaemias	0.659	0.341	0.000
M89.96 Disorder of bone, unspecified (Lower leg)	0.658	0.341	0.000
E10.8 With unspecified complications	0.658	0.341	0.000
M89.95 Disorder of bone, unspecified (Pelvic region and thigh)	0.658	0.342	0.000
M22 Disorders of patella	0.658	0.342	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.658	0.342	0.000
M32.8 Other forms of systemic lupus erythematosus	0.658	0.342	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.658	0.342	0.000
M31.7 Microscopic polyangiitis	0.656	0.344	0.000
E10.0 With coma	0.652	0.348	0.000
E06.3 Autoimmune thyroiditis	0.651	0.349	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.649	0.351	0.000
M62.86 Other specified disorders of muscle (Lower leg)	0.649	0.351	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.648	0.351	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.648	0.352	0.000
L40.4 Guttate psoriasis	0.648	0.352	0.000
M86 Osteomyelitis	0.648	0.352	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.648	0.352	0.000
M61 Calcification and ossification of muscle	0.648	0.352	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.647	0.352	0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)	0.645	0.355	0.000
L10-L14 Bullous disorders	0.645	0.355	0.000
E06.1 Subacute thyroiditis	0.643	0.357	0.000
M25.98 Joint disorder, unspecified (Other)	0.643	0.357	0.000
M25.92 Joint disorder, unspecified (Upper arm)	0.643	0.357	0.000
M25.90 Joint disorder, unspecified (Multiple sites)	0.643	0.357	0.000
E14 Unspecified diabetes mellitus	0.643	0.357	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.643	0.357	0.000
M25.36 Other instability of joint (Lower leg)	0.642	0.358	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.641	0.358	0.000
E06.5 Other chronic thyroiditis	0.641	0.359	0.000
K51.8 Other ulcerative colitis	0.000	0.361	0.639
M11.1 Familial chondrocalcinosis	0.639	0.361	0.000
M11.0 Hydroxyapatite deposition disease	0.639	0.361	0.000
E10.7 With multiple complications	0.639	0.361	0.000
M25.70 Osteophyte (Multiple sites)	0.639	0.361	0.000
L40.3 Pustulosis palmaris et plantaris	0.638	0.361	0.000
M89.87 Other specified disorders of bone (Ankle and foot)	0.637	0.363	0.000
M25.59 Pain in joint (Site unspecified)	0.635	0.365	0.000
B37.0 Candidal stomatitis	0.634	0.366	0.000
L40.2 Acrodermatitis continua	0.634	0.366	0.000
M25.97 Joint disorder, unspecified (Ankle and foot)	0.633	0.367	0.000
M08.0 Juvenile rheumatoid arthritis	0.630	0.370	0.000
M11.8 Other specified crystal arthropathies	0.627	0.372	0.000
A00-A09 Intestinal infectious diseases	0.627	0.373	0.000
M34.0 Progressive systemic sclerosis	0.625	0.375	0.000
B02 Zoster [herpes zoster]	0.624	0.376	0.000
D68.0 Von Willebrand's disease	0.623	0.377	0.000
M25.94 Joint disorder, unspecified (Hand)	0.622	0.377	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.622	0.378	0.000
M31.8 Other specified necrotising vasculopathies	0.621	0.379	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.621	0.379	0.000
M31.2 Lethal midline granuloma	0.621	0.379	0.000
M11.9 Crystal arthropathy, unspecified	0.620	0.379	0.000
M25.0 Haemarthrosis	0.619	0.380	0.000
M24.6 Ankylosis of joint	0.619	0.381	0.000
E06.4 Drug-induced thyroiditis	0.618	0.382	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.618	0.382	0.000
E06.0 Acute thyroiditis	0.618	0.382	0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.616	0.383	0.000
E13 Other specified diabetes mellitus	0.616	0.384	0.000
M89.94 Disorder of bone, unspecified (Hand)	0.615	0.385	0.000
M24.7 Protrusio acetabuli	0.615	0.385	0.000
A08 Viral and other specified intestinal infections	0.615	0.385	0.000
M62.0 Diastasis of muscle	0.614	0.386	0.000
E12 Malnutrition-related diabetes mellitus	0.613	0.387	0.000
M89.90 Disorder of bone, unspecified (Multiple sites)	0.612	0.388	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.612	0.388	0.000
A15-A19 Tuberculosis	0.610	0.390	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.609	0.391	0.000
A08.4 Viral intestinal infection, unspecified	0.607	0.393	0.000
M24.27 Disorder of ligament (Ankle and foot)	0.607	0.393	0.000
G31.8 Other specified degenerative diseases of nervous system	0.607	0.393	0.000
A65-A69 Other spirochaetal diseases	0.607	0.393	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.606	0.394	0.000
B65-B83 Helminthiases	0.606	0.394	0.000
M24.9 Joint derangement, unspecified	0.606	0.394	0.000
B00 Herpesviral [herpes simplex] infections	0.604	0.396	0.000
M24.21 Disorder of ligament (Shoulder region)	0.603	0.397	0.000
M87.20 Osteonecrosis due to previous trauma (Multiple sites)	0.603	0.397	0.000
F31.0 Bipolar affective disorder, current episode hypomanic	0.603	0.397	0.000
E07.8 Other specified disorders of thyroid	0.602	0.398	0.000
D68.5 Primary Thrombophilia	0.602	0.398	0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.601	0.398	0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms	0.601	0.399	0.000
A20-A28 Certain zoonotic bacterial diseases	0.601	0.399	0.000
K50.8 Other Crohn's disease	0.000	0.399	0.601
I83 Varicose veins of lower extremities	0.000	0.400	0.600
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.598	0.402	0.000
M93.9 Osteochondropathy, unspecified	0.597	0.403	0.000
E40-E46 Malnutrition	0.597	0.403	0.000
M62.4 Contracture of muscle	0.596	0.404	0.000
M62.3 Immobility syndrome (paraplegic)	0.596	0.404	0.000
M62.2 Ischaemic infarction of muscle	0.596	0.404	0.000
M89.38 Hypertrophy of bone (Other)	0.596	0.404	0.000
B37.3 Candidiasis of vulva and vagina	0.596	0.404	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.596	0.404	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.596	0.404	0.000
M89.06 Algoneurodystrophy (Lower leg)	0.596	0.404	0.000
B25-B34 Other viral diseases	0.595	0.405	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.595	0.405	0.000
M66 Spontaneous rupture of synovium and tendon	0.595	0.405	0.000
M35.8 Other specified systemic involvement of connective tissue	0.595	0.405	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.594	0.406	0.000
E10.6 With other specified complications	0.594	0.406	0.000
M11.29 Other chondrocalcinosis (Site unspecified)	0.593	0.407	0.000
M11.28 Other chondrocalcinosis (Other)	0.593	0.407	0.000
M11.27 Other chondrocalcinosis (Ankle and foot)	0.593	0.407	0.000
M11.25 Other chondrocalcinosis (Pelvic region and thigh)	0.593	0.407	0.000
M11.24 Other chondrocalcinosis (Hand)	0.593	0.407	0.000
M11.23 Other chondrocalcinosis (Forearm)	0.593	0.407	0.000
M11.22 Other chondrocalcinosis (Upper arm)	0.593	0.407	0.000
M11.21 Other chondrocalcinosis (Shoulder region)	0.593	0.407	0.000
M11.20 Other chondrocalcinosis (Multiple sites)	0.593	0.407	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.593	0.407	0.000
M62.88 Other specified disorders of muscle (Other)	0.593	0.407	0.000
M67.8 Other specified disorders of synovium and tendon	0.593	0.407	0.000
D59.1 Other autoimmune haemolytic anaemias	0.592	0.408	0.000
L44 Other papulosquamous disorders	0.592	0.408	0.000
L41 Parapsoriasis	0.592	0.408	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.592	0.408	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.592	0.408	0.000
M94 Other disorders of cartilage	0.590	0.410	0.000
M25.33 Other instability of joint (Forearm)	0.590	0.410	0.000
D56 Thalassaemia	0.590	0.410	0.000
B37.4 Candidiasis of other urogenital sites	0.588	0.412	0.000
M62.6 Muscle strain	0.588	0.412	0.000
M07.69 Other enteropathic arthropathies (Site unspecified)	0.586	0.414	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.585	0.414	0.000
F02.0 Dementia in Pick's disease	0.583	0.417	0.000
M31.9 Necrotising vasculopathy, unspecified	0.582	0.417	0.000
M89.59 Osteolysis (Site unspecified)	0.582	0.418	0.000
M89.58 Osteolysis (Other)	0.582	0.418	0.000
M89.57 Osteolysis (Ankle and foot)	0.582	0.418	0.000
M89.56 Osteolysis (Lower leg)	0.582	0.418	0.000
M89.54 Osteolysis (Hand)	0.582	0.418	0.000
M89.53 Osteolysis (Forearm)	0.582	0.418	0.000
M89.52 Osteolysis (Upper arm)	0.582	0.418	0.000
M89.51 Osteolysis (Shoulder region)	0.582	0.418	0.000
M89.50 Osteolysis (Multiple sites)	0.582	0.418	0.000
M25.37 Other instability of joint (Ankle and foot)	0.582	0.418	0.000
M93.1 Kienbock's disease of adults	0.581	0.419	0.000
M89.92 Disorder of bone, unspecified (Upper arm)	0.581	0.419	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.581	0.419	0.000
D67 Hereditary factor IX deficiency	0.580	0.419	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.580	0.420	0.000
B36 Other superficial mycoses	0.580	0.420	0.000
L43 Lichen planus	0.578	0.422	0.000
F09 Unspecified organic or symptomatic mental disorder	0.578	0.422	0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.578	0.422	0.000
F31.6 Bipolar affective disorder, current episode mixed	0.577	0.423	0.000
G36 Other acute disseminated demyelination	0.576	0.424	0.000
M89.99 Disorder of bone, unspecified (Site unspecified)	0.575	0.425	0.000
M89.93 Disorder of bone, unspecified (Forearm)	0.575	0.425	0.000
M89.91 Disorder of bone, unspecified (Shoulder region)	0.575	0.425	0.000
M24.23 Disorder of ligament (Forearm)	0.574	0.426	0.000
B02.9 Zoster without complication	0.574	0.426	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.574	0.426	0.000
K51.5 Mucosal proctocolitis	0.000	0.429	0.571
F70-F79 Mental retardation	0.571	0.429	0.000
G31.9 Degenerative disease of nervous system, unspecified	0.570	0.430	0.000
M89.39 Hypertrophy of bone (Site unspecified)	0.569	0.431	0.000
M89.36 Hypertrophy of bone (Lower leg)	0.569	0.431	0.000
M89.35 Hypertrophy of bone (Pelvic region and thigh)	0.569	0.431	0.000
M89.34 Hypertrophy of bone (Hand)	0.569	0.431	0.000
M89.33 Hypertrophy of bone (Forearm)	0.569	0.431	0.000
M89.32 Hypertrophy of bone (Upper arm)	0.569	0.431	0.000
M89.31 Hypertrophy of bone (Shoulder region)	0.569	0.431	0.000
M89.30 Hypertrophy of bone (Multiple sites)	0.569	0.431	0.000
M87.27 Osteonecrosis due to previous trauma (Ankle and foot)	0.569	0.431	0.000
M10.02 Idiopathic gout (Upper arm)	0.568	0.432	0.000
M24.28 Disorder of ligament (Other)	0.567	0.433	0.000
F01.1 Multi-infarct dementia	0.566	0.434	0.000
F31.9 Bipolar affective disorder, unspecified	0.563	0.437	0.000
M31.0 Hypersensitivity angiitis	0.563	0.437	0.000
M87.1 Osteonecrosis due to drugs	0.563	0.437	0.000
E14.5 With peripheral circulatory complications	0.562	0.438	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.562	0.438	0.000
F02.4 Dementia in human immunodeficiency virus [HIV] disease	0.561	0.439	0.000
F02.2 Dementia in Huntington's disease	0.561	0.439	0.000
F02.1 Dementia in Creutzfeldt-Jakob disease	0.561	0.439	0.000
F39 Unspecified mood [affective] disorder	0.561	0.439	0.000
E07.9 Disorder of thyroid, unspecified	0.561	0.439	0.000
M08.9 Juvenile arthritis, unspecified	0.560	0.440	0.000
M08.8 Other juvenile arthritis	0.560	0.440	0.000
M08.4 Pauciarticular juvenile arthritis	0.560	0.440	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.560	0.440	0.000
M08.2 Juvenile arthritis with systemic onset	0.560	0.440	0.000
M08.1 Juvenile ankylosing spondylitis	0.560	0.440	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.560	0.440	0.000
M62.9 Disorder of muscle, unspecified	0.560	0.440	0.000
M62.87 Other specified disorders of muscle (Ankle and foot)	0.560	0.440	0.000
B99-B99 Other infectious diseases	0.559	0.441	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.557	0.443	0.000
L40.8 Other psoriasis	0.557	0.443	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.556	0.444	0.000
M10.06 Idiopathic gout (Lower leg)	0.556	0.444	0.000
M60.9 Myositis, unspecified	0.556	0.444	0.000
E50-E64 Other nutritional deficiencies	0.555	0.445	0.000
D73.5 Infarction of spleen	0.555	0.445	0.000
D57 Sickle-cell disorders	0.554	0.446	0.000
D55 Anaemia due to enzyme disorders	0.554	0.446	0.000
K51.1 Ulcerative (chronic) ileocolitis	0.000	0.447	0.553
F40-F48 Neurotic, stress-related and somatoform disorders	0.552	0.448	0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression	0.552	0.448	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.552	0.448	0.000
A75-A79 Rickettsioses	0.552	0.448	0.000
A70-A74 Other diseases caused by chlamydiae	0.552	0.448	0.000
M87.3 Other secondary osteonecrosis	0.551	0.449	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.551	0.449	0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.550	0.450	0.000
M36.3 Arthropathy in other blood disorders	0.550	0.450	0.000
M36.2 Haemophilic arthropathy	0.550	0.450	0.000
M36.1 Arthropathy in neoplastic disease	0.550	0.450	0.000
M36.0 Dermato(poly)myositis in neoplastic disease	0.550	0.450	0.000
M89.07 Algoneurodystrophy (Ankle and foot)	0.550	0.450	0.000
G70-G73 Diseases of myoneural junction and muscle	0.549	0.451	0.000
M67.4 Ganglion	0.549	0.451	0.000
D73.9 Disease of spleen, unspecified	0.549	0.451	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.548	0.452	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.000	0.453	0.547
G32 Other degenerative disorders of nervous system in diseases classified elsewhere	0.546	0.454	0.000
M14.2 Diabetic arthropathy	0.546	0.454	0.000
B15-B19 Viral hepatitis	0.545	0.455	0.000
F31.8 Other bipolar affective disorders	0.544	0.456	0.000
F38 Other mood [affective] disorders	0.544	0.456	0.000
G30 Alzheimer's disease	0.543	0.457	0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.543	0.457	0.000
D74 Methaemoglobinaemia	0.543	0.457	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.543	0.457	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.543	0.457	0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)	0.542	0.458	0.000
M10.00 Idiopathic gout (Multiple sites)	0.542	0.458	0.000
M07.68 Other enteropathic arthropathies (Other)	0.542	0.458	0.000
M07.67 Other enteropathic arthropathies (Ankle and foot)	0.542	0.458	0.000
M07.66 Other enteropathic arthropathies (Lower leg)	0.542	0.458	0.000
M07.65 Other enteropathic arthropathies (Pelvic region and thigh)	0.542	0.458	0.000
M07.64 Other enteropathic arthropathies (Hand)	0.542	0.458	0.000
M07.63 Other enteropathic arthropathies (Forearm)	0.542	0.458	0.000
M07.62 Other enteropathic arthropathies (Upper arm)	0.542	0.458	0.000
M07.61 Other enteropathic arthropathies (Shoulder region)	0.542	0.458	0.000
M07.60 Other enteropathic arthropathies (Multiple sites)	0.542	0.458	0.000
M10.4 Other secondary gout	0.541	0.459	0.000
M10.3 Gout due to impairment of renal function	0.541	0.459	0.000
M10.2 Drug-induced gout	0.541	0.459	0.000
M10.1 Lead-induced gout	0.541	0.459	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.541	0.459	0.000
K50.1 Crohn's disease of large intestine	0.000	0.459	0.541
M87.8 Other osteonecrosis	0.540	0.460	0.000
F31.7 Bipolar affective disorder, currently in remission	0.540	0.460	0.000
B48 Other mycoses, not elsewhere classified	0.539	0.460	0.000
B47 Mycetoma	0.539	0.460	0.000
B46 Zygomycosis	0.539	0.460	0.000
B45 Cryptococcosis	0.539	0.460	0.000
B43 Chromomycosis and phaeomycotic abscess	0.539	0.460	0.000
B42 Sporotrichosis	0.539	0.460	0.000
B41 Paracoccidioidomycosis	0.539	0.460	0.000
B40 Blastomycosis	0.539	0.460	0.000
B39 Histoplasmosis	0.539	0.460	0.000
B38 Coccidioidomycosis	0.539	0.460	0.000
D58.0 Hereditary spherocytosis	0.539	0.461	0.000
M91.2 Coxa plana	0.538	0.462	0.000
F60-F69 Disorders of adult personality and behaviour	0.538	0.462	0.000
B37.6 Candidal endocarditis	0.537	0.463	0.000
B37.5 Candidal meningitis	0.537	0.463	0.000
M25.79 Osteophyte (Site unspecified)	0.537	0.463	0.000
M24.19 Other articular cartilage disorders (Site unspecified)	0.537	0.463	0.000
M24.18 Other articular cartilage disorders (Other)	0.537	0.463	0.000
M24.14 Other articular cartilage disorders (Hand)	0.537	0.463	0.000
M24.12 Other articular cartilage disorders (Upper arm)	0.537	0.463	0.000
M24.10 Other articular cartilage disorders (Multiple sites)	0.537	0.463	0.000
B49 Unspecified mycosis	0.537	0.463	0.000
F45 Somatoform disorders	0.536	0.464	0.000
E07.1 Dyshormogenetic goitre	0.535	0.465	0.000
E07.0 Hypersecretion of calcitonin	0.535	0.465	0.000
M25.39 Other instability of joint (Site unspecified)	0.534	0.466	0.000
M25.38 Other instability of joint (Other)	0.534	0.466	0.000
M25.35 Other instability of joint (Pelvic region and thigh)	0.534	0.466	0.000
M25.32 Other instability of joint (Upper arm)	0.534	0.466	0.000
M25.30 Other instability of joint (Multiple sites)	0.534	0.466	0.000
M62.56 Muscle wasting and atrophy, not elsewhere classified (Lower leg)	0.533	0.467	0.000
B00.5 Herpesviral ocular disease	0.533	0.467	0.000
G37.5 Concentric sclerosis [Balo]	0.532	0.468	0.000
G37.4 Subacute necrotising myelitis	0.532	0.468	0.000
G37.2 Central pontine myelinolysis	0.532	0.468	0.000
G37.1 Central demyelination of corpus callosum	0.532	0.468	0.000
G37.0 Diffuse sclerosis	0.532	0.468	0.000
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.532	0.468	0.000
M89.00 Algoneurodystrophy (Multiple sites)	0.531	0.469	0.000
M62.84 Other specified disorders of muscle (Hand)	0.530	0.470	0.000
M24.26 Disorder of ligament (Lower leg)	0.530	0.470	0.000
F01.8 Other vascular dementia	0.529	0.471	0.000
F01.3 Mixed cortical and subcortical vascular dementia	0.529	0.471	0.000
F01.2 Subcortical vascular dementia	0.529	0.471	0.000
F01.0 Vascular dementia of acute onset	0.529	0.471	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.528	0.471	0.000
D58.2 Other haemoglobinopathies	0.527	0.473	0.000
M33.1 Other dermatomyositis	0.527	0.473	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.526	0.474	0.000
D69 Purpura and other haemorrhagic conditions	0.526	0.474	0.000
M25.91 Joint disorder, unspecified (Shoulder region)	0.524	0.475	0.000
M89.40 Other hypertrophic osteoarthropathy (Multiple sites)	0.524	0.476	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations