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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs403414
log Bayes Factor = 7.99105
Chromosome 6   position 32,977,315  (GRCh37) Explore rs403414 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.005 0.995
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.953 0.047 0.000
T42.4 Benzodiazepines
0.948 0.052 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.947 0.053 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.938 0.062 0.000
E10.5 With peripheral circulatory complications
0.000 0.099 0.901
E10-E14 Diabetes mellitus
0.000 0.105 0.895
E10.1 With ketoacidosis
0.000 0.116 0.884
E03.9 Hypothyroidism, unspecified
0.000 0.129 0.871
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.860 0.140 0.000
K90.0 Coeliac disease
0.000 0.142 0.858
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.855 0.145 0.000
E03 Other hypothyroidism
0.000 0.146 0.854
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.148 0.852
E00-E07 Disorders of thyroid gland
0.000 0.149 0.851
T46 Poisoning by agents primarily affecting the cardiovascular system
0.846 0.154 0.000
E10.2 With renal complications
0.000 0.166 0.834
E10.0 With coma
0.000 0.180 0.820
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.195 0.805
T43.3 Phenothiazine antipsychotics and neuroleptics
0.800 0.200 0.000
E10.6 With other specified complications
0.000 0.201 0.799
T50.9 Other and unspecified drugs, medicaments and biological substances
0.795 0.205 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.228 0.772
E10.4 With neurological complications
0.000 0.231 0.769
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.754 0.246 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.248 0.752
T46.4 Angiotensin-converting-enzyme inhibitors
0.751 0.249 0.000
E10.8 With unspecified complications
0.000 0.257 0.742
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.731 0.269 0.000
E13 Other specified diabetes mellitus
0.000 0.271 0.729
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.724 0.276 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.718 0.282 0.000
E10.7 With multiple complications
0.000 0.283 0.717
T42.1 Iminostilbenes
0.717 0.283 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.716 0.284 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.708 0.292 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.706 0.294 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.702 0.298 0.000
T43.6 Psychostimulants with abuse potential
0.690 0.310 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.683 0.317 0.000
T42.3 Barbiturates
0.683 0.317 0.000
T42.2 Succinimides and oxazolidinediones
0.683 0.317 0.000
T42.0 Hydantoin derivatives
0.682 0.318 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.672 0.327 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.672 0.327 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.672 0.327 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.668 0.332 0.000
T46.1 Calcium-channel blockers
0.658 0.342 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.658 0.342 0.000
E07 Other disorders of thyroid
0.000 0.346 0.654
T43.4 Butyrophenone and thioxanthene neuroleptics
0.647 0.353 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.646 0.354 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.358 0.642
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.369 0.631
T36 Poisoning by systemic antibiotics
0.624 0.376 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.622 0.378 0.000
T43.9 Psychotropic drug, unspecified
0.617 0.383 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.617 0.383 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.617 0.383 0.000
T50.4 Drugs affecting uric acid metabolism
0.614 0.386 0.000
T50.8 Diagnostic agents
0.613 0.387 0.000
T50.7 Analeptics and opioid receptor antagonists
0.613 0.387 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.613 0.387 0.000
T50.5 Appetite depressants
0.613 0.387 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.613 0.387 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.613 0.387 0.000
T50.1 Loop [high-ceiling] diuretics
0.613 0.387 0.000
T50.0 Mineralocorticoids and their antagonists
0.613 0.387 0.000
E03.5 Myxoedema coma
0.000 0.387 0.613
E03.4 Atrophy of thyroid (acquired)
0.000 0.387 0.613
E03.3 Postinfectious hypothyroidism
0.000 0.387 0.613
E03.1 Congenital hypothyroidism without goitre
0.000 0.387 0.613
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.612 0.388 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.389 0.610
E00 Congenital iodine-deficiency syndrome
0.000 0.389 0.610
E13.9 Without complications
0.000 0.391 0.609
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.607 0.393 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.607 0.393 0.000
T46.7 Peripheral vasodilators
0.607 0.393 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.607 0.393 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.607 0.393 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.399 0.601
T40.4 Other synthetic narcotics
0.600 0.400 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.404 0.596
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.596 0.404 0.000
E14 Unspecified diabetes mellitus
0.000 0.415 0.585
E04 Other non-toxic goitre
0.000 0.420 0.580
T39.1 4-Aminophenol derivatives
0.579 0.421 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.422 0.577
T46.5 Other antihypertensive drugs, not elsewhere classified
0.576 0.424 0.000
T45.0 Antiallergic and antiemetic drugs
0.571 0.429 0.000
E03.8 Other specified hypothyroidism
0.000 0.432 0.568
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.000 0.433 0.567
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.557 0.443 0.000
T48.6 Antiasthmatics, not elsewhere classified
0.556 0.444 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.446 0.554
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.446 0.554
E16.4 Abnormal secretion of gastrin
0.000 0.446 0.554
E16.3 Increased secretion of glucagon
0.000 0.446 0.554
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.000 0.448 0.552
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.000 0.451 0.549
E04.2 Non-toxic multinodular goitre
0.000 0.453 0.547
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.547 0.453 0.000
T43.2 Other and unspecified antidepressants
0.546 0.454 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.457 0.543
C78.2 Secondary malignant neoplasm of pleura
0.000 0.457 0.543
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.541 0.459 0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.541 0.459 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.541 0.459 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.541 0.459 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.541 0.459 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.541 0.459 0.000
T44.0 Anticholinesterase agents
0.541 0.459 0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.540 0.460 0.000
C77.2 Intra-abdominal lymph nodes
0.000 0.460 0.540
E50-E64 Other nutritional deficiencies
0.000 0.460 0.539
T47.1 Other antacids and anti-gastric-secretion drugs
0.539 0.461 0.000
C78.0 Secondary malignant neoplasm of lung
0.000 0.463 0.537
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.000 0.468 0.532
C77.9 Lymph node, unspecified
0.000 0.468 0.532
E65-E68 Obesity and other hyperalimentation
0.000 0.469 0.531
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.524 0.475 0.000
T40.8 Lysergide [LSD]
0.524 0.475 0.000
T40.7 Cannabis (derivatives)
0.524 0.475 0.000
T40.5 Cocaine
0.524 0.475 0.000
T40.3 Methadone
0.524 0.475 0.000
T40.1 Heroin
0.524 0.475 0.000
T40.0 Opium
0.524 0.475 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.476 0.524
E13.8 With unspecified complications
0.000 0.477 0.522
E13.7 With multiple complications
0.000 0.477 0.522
E13.6 With other specified complications
0.000 0.477 0.522
E13.5 With peripheral circulatory complications
0.000 0.477 0.522
E13.4 With neurological complications
0.000 0.477 0.522
E13.3 With ophthalmic complications
0.000 0.477 0.522
E13.2 With renal complications
0.000 0.477 0.522
E13.1 With ketoacidosis
0.000 0.477 0.522
E13.0 With coma
0.000 0.477 0.522
E05.9 Thyrotoxicosis, unspecified
0.000 0.478 0.522
T40.2 Other opioids
0.520 0.480 0.000
E06 Thyroiditis
0.000 0.482 0.518
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.513 0.487 0.000
T48.5 Anti-common-cold drugs
0.513 0.487 0.000
T48.4 Expectorants
0.513 0.487 0.000
T48.3 Antitussives
0.513 0.487 0.000
T48.2 Other and unspecified agents primarily acting on muscles
0.513 0.487 0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.513 0.487 0.000
T48.0 Oxytocic drugs
0.513 0.487 0.000
T38.9 Other and unspecified hormone antagonists
0.508 0.492 0.000
T38.8 Other and unspecified hormones and their synthetic substitutes
0.508 0.492 0.000
T38.7 Androgens and anabolic congeners
0.508 0.492 0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.508 0.492 0.000
T38.5 Other oestrogens and progestogens
0.508 0.492 0.000
T38.4 Oral contraceptives
0.508 0.492 0.000
T38.2 Antithyroid drugs
0.508 0.492 0.000
T38.0 Glucocorticoids and synthetic analogues
0.508 0.492 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.506 0.494 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.506 0.494 0.000
T47.7 Emetics
0.506 0.494 0.000
T47.6 Antidiarrhoeal drugs
0.506 0.494 0.000
T47.5 Digestants
0.506 0.494 0.000
T47.4 Other laxatives
0.506 0.494 0.000
T47.3 Saline and osmotic laxatives
0.506 0.494 0.000
T47.2 Stimulant laxatives
0.506 0.494 0.000
T47.0 Histamine H(2)-receptor antagonists
0.506 0.494 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.000 0.495 0.505
T38.1 Thyroid hormones and substitutes
0.504 0.496 0.000
T39.4 Antirheumatics, not elsewhere classified
0.503 0.497 0.000
T39.2 Pyrazolone derivatives
0.503 0.497 0.000
T40.6 Other and unspecified narcotics
0.503 0.497 0.000
C77.3 Axillary and upper limb lymph nodes
0.000 0.500 0.500
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.482 0.518 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.482 0.518 0.000
T37.5 Antiviral drugs
0.482 0.518 0.000
T37.4 Anthelminthics
0.482 0.518 0.000
T37.3 Other antiprotozoal drugs
0.482 0.518 0.000
T37.2 Antimalarials and drugs acting on other blood protozoa
0.482 0.518 0.000
T37.1 Antimycobacterial drugs
0.482 0.518 0.000
T37.0 Sulphonamides
0.482 0.518 0.000
T41.5 Therapeutic gases
0.482 0.518 0.000
T41.4 Anaesthetic, unspecified
0.482 0.518 0.000
T41.3 Local anaesthetics
0.482 0.518 0.000
T41.2 Other and unspecified general anaesthetics
0.482 0.518 0.000
T41.1 Intravenous anaesthetics
0.482 0.518 0.000
T41.0 Inhaled anaesthetics
0.482 0.518 0.000
T49.9 Topical agent, unspecified
0.482 0.518 0.000
T49.8 Other topical agents
0.482 0.518 0.000
T49.7 Dental drugs, topically applied
0.482 0.518 0.000
T49.6 Otorhinolaryngological drugs and preparations
0.482 0.518 0.000
T49.5 Ophthalmological drugs and preparations
0.482 0.518 0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.482 0.518 0.000
T49.3 Emollients, demulcents and protectants
0.482 0.518 0.000
T49.2 Local astringents and local detergents
0.482 0.518 0.000
T49.1 Antipruritics
0.482 0.518 0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.482 0.518 0.000
T39.0 Salicylates
0.481 0.519 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.479 0.521 0.000
T45.8 Other primarily systemic and haematological agents
0.479 0.521 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.479 0.521 0.000
T45.6 Fibrinolysis-affecting drugs
0.479 0.521 0.000
T45.4 Iron and its compounds
0.479 0.521 0.000
T45.3 Enzymes, not elsewhere classified
0.479 0.521 0.000
E14.3 With ophthalmic complications
0.000 0.527 0.473
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.000 0.529 0.471
E40-E46 Malnutrition
0.000 0.531 0.469
E07.1 Dyshormogenetic goitre
0.000 0.531 0.469
E07.0 Hypersecretion of calcitonin
0.000 0.531 0.469
C78.4 Secondary malignant neoplasm of small intestine
0.000 0.534 0.466
E16.1 Other hypoglycaemia
0.000 0.538 0.461
C77.4 Inguinal and lower limb lymph nodes
0.000 0.539 0.461
E12.9 Without complications
0.000 0.539 0.460
E12.8 With unspecified complications
0.000 0.539 0.460
E12.7 With multiple complications
0.000 0.539 0.460
E12.6 With other specified complications
0.000 0.539 0.460
E12.5 With peripheral circulatory complications
0.000 0.539 0.460
E12.4 With neurological complications
0.000 0.539 0.460
E12.3 With ophthalmic complications
0.000 0.539 0.460
E12.2 With renal complications
0.000 0.539 0.460
E12.1 With ketoacidosis
0.000 0.539 0.460
E12.0 With coma
0.000 0.539 0.460
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.454 0.546 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.551 0.449
T36.9 Systemic antibiotic, unspecified
0.447 0.552 0.000
T36.8 Other systemic antibiotics
0.447 0.552 0.000
T36.7 Antifungal antibiotics, systemically used
0.447 0.552 0.000
T36.6 Rifamycins
0.447 0.552 0.000
T36.5 Aminoglycosides
0.447 0.552 0.000
T36.4 Tetracyclines
0.447 0.552 0.000
T36.3 Macrolides
0.447 0.552 0.000
T36.2 Chloramphenicol group
0.447 0.552 0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.447 0.552 0.000
E65 Localised adiposity
0.000 0.557 0.443
E14.8 With unspecified complications
0.000 0.562 0.438
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.562 0.438
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.562 0.438
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.562 0.438
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.562 0.438
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.562 0.438
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.562 0.438
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.562 0.438
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.562 0.438
T45.1 Antineoplastic and immunosuppressive drugs
0.438 0.562 0.000
E53 Deficiency of other B group vitamins
0.000 0.564 0.436
T45.2 Vitamins, not elsewhere classified
0.436 0.564 0.000
E05.5 Thyroid crisis or storm
0.000 0.569 0.431
E05.4 Thyrotoxicosis factitia
0.000 0.569 0.431
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.569 0.431
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.569 0.431
E14.7 With multiple complications
0.000 0.581 0.419
E14.6 With other specified complications
0.000 0.581 0.419
E14.5 With peripheral circulatory complications
0.000 0.581 0.419
E14.2 Withrenal complications
0.000 0.581 0.419
E14.0 With coma
0.000 0.581 0.419
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.583 0.417
T45.5 Anticoagulants
0.416 0.584 0.000
E04.8 Other specified non-toxic goitre
0.000 0.584 0.416
E07.8 Other specified disorders of thyroid
0.000 0.584 0.416
C77.0 Lymph nodes of head, face and neck
0.000 0.586 0.414
E05.8 Other thyrotoxicosis
0.000 0.597 0.403
C80 Malignant neoplasm without specification of site
0.000 0.598 0.402
E14.9 Without complications
0.000 0.600 0.400
T36.0 Penicillins
0.399 0.601 0.000
E14.1 With ketoacidosis
0.000 0.602 0.398
K90 Intestinal malabsorption
0.000 0.604 0.396
E55 Vitamin D deficiency
0.000 0.606 0.394
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.000 0.613 0.387
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.613 0.387
E63 Other nutritional deficiencies
0.000 0.613 0.387
E56 Other vitamin deficiencies
0.000 0.613 0.387
E51 Thiamine deficiency
0.000 0.613 0.387
E50 Vitamin A deficiency
0.000 0.613 0.387
E60 Dietary zinc deficiency
0.000 0.613 0.387
E59 Dietary selenium deficiency
0.000 0.613 0.387
E54 Ascorbic acid deficiency
0.000 0.613 0.387
E52 Niacin deficiency [pellagra]
0.000 0.613 0.387
E67 Other hyperalimentation
0.000 0.619 0.381
E68 Sequelae of hyperalimentation
0.000 0.619 0.381
E20-E35 Disorders of other endocrine glands
0.000 0.620 0.380
E53.8 Deficiency of other specified B group vitamins
0.000 0.625 0.375
E06.5 Other chronic thyroiditis
0.000 0.629 0.371
E06.4 Drug-induced thyroiditis
0.000 0.629 0.371
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.629 0.371
E06.1 Subacute thyroiditis
0.000 0.629 0.371
E06.0 Acute thyroiditis
0.000 0.629 0.371
T43.0 Tricyclic and tetracyclic antidepressants
0.369 0.631 0.000
E58 Dietary calcium deficiency
0.000 0.631 0.368
E11 Non-insulin-dependent diabetes mellitus
0.000 0.640 0.360
E27 Other disorders of adrenal gland
0.000 0.648 0.352
C76 Malignant neoplasm of other and ill-defined sites
0.000 0.648 0.352
E04.0 Non-toxic diffuse goitre
0.000 0.648 0.351
C77.8 Lymph nodes of multiple regions
0.000 0.653 0.347
C79 Secondary malignant neoplasm of other sites
0.000 0.655 0.345
K90.9 Intestinal malabsorption, unspecified
0.000 0.657 0.343
C78.1 Secondary malignant neoplasm of mediastinum
0.000 0.658 0.342
E06.9 Thyroiditis, unspecified
0.000 0.662 0.338
E04.1 Non-toxic single thyroid nodule
0.000 0.662 0.338
C80.0 Malignant neoplasm, primary site unknown, so stated
0.000 0.663 0.337
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.664 0.336
E45 Retarded development following protein-energy malnutrition
0.000 0.664 0.336
E43 Unspecified severe protein-energy malnutrition
0.000 0.664 0.336
E42 Marasmic kwashiorkor
0.000 0.664 0.336
E41 Nutritional marasmus
0.000 0.664 0.336
E40 Kwashiorkor
0.000 0.664 0.336
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.336 0.664 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.670 0.330
E06.3 Autoimmune thyroiditis
0.000 0.677 0.323
E53.1 Pyridoxine deficiency
0.000 0.687 0.313
E53.0 Riboflavin deficiency
0.000 0.687 0.313
E11.3 With ophthalmic complications
0.000 0.689 0.311
E27.9 Disorder of adrenal gland, unspecified
0.000 0.693 0.306
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.705 0.295
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.000 0.708 0.292
E11.6 With other specified complications
0.000 0.709 0.291
E14.4 With neurological complications
0.001 0.710 0.290
E55.9 Vitamin D deficiency, unspecified
0.000 0.710 0.290
E53.9 Vitamin B deficiency, unspecified
0.000 0.712 0.288
C79.6 Secondary malignant neoplasm of ovary
0.000 0.712 0.288
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.000 0.713 0.287
K90.3 Pancreatic steatorrhoea
0.000 0.716 0.284
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.716 0.284
K90.1 Tropical sprue
0.000 0.716 0.284
E55.0 Rickets, active
0.000 0.717 0.282
E50.9 Vitamin A deficiency, unspecified
0.000 0.722 0.277
E50.8 Other manifestations of vitamin A deficiency
0.000 0.722 0.277
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.722 0.277
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.722 0.277
E50.5 Vitamin A deficiency with night blindness
0.000 0.722 0.277
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.722 0.277
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.722 0.277
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.722 0.277
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.722 0.277
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.722 0.277
E51.9 Thiamine deficiency, unspecified
0.000 0.722 0.277
E51.8 Other manifestations of thiamine deficiency
0.000 0.722 0.277
E51.2 Wernicke's encephalopathy
0.000 0.722 0.277
E51.1 Beriberi
0.000 0.722 0.277
E56.9 Vitamin deficiency, unspecified
0.000 0.722 0.277
E56.8 Deficiency of other vitamins
0.000 0.722 0.277
E56.1 Deficiency of vitamin K
0.000 0.722 0.277
E56.0 Deficiency of vitamin E
0.000 0.722 0.277
E63.9 Nutritional deficiency, unspecified
0.000 0.722 0.277
E63.8 Other specified nutritional deficiencies
0.000 0.722 0.277
E63.1 Imbalance of constituents of food intake
0.000 0.722 0.277
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.722 0.277
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.722 0.277
E64.8 Sequelae of other nutritional deficiencies
0.000 0.722 0.277
E64.3 Sequelae of rickets
0.000 0.722 0.277
E64.2 Sequelae of vitamin C deficiency
0.000 0.722 0.277
E64.1 Sequelae of vitamin A deficiency
0.000 0.722 0.277
E64.0 Sequelae of protein-energy malnutrition
0.000 0.722 0.277
E26 Hyperaldosteronism
0.000 0.723 0.277
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.726 0.274
E67.8 Other specified hyperalimentation
0.000 0.727 0.273
E67.3 Hypervitaminosis D
0.000 0.727 0.273
E67.2 Megavitamin-B6 syndrome
0.000 0.727 0.273
E67.1 Hypercarotenaemia
0.000 0.727 0.273
E67.0 Hypervitaminosis A
0.000 0.727 0.273
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.727 0.273
E32 Diseases of thymus
0.000 0.727 0.273
E31 Polyglandular dysfunction
0.000 0.727 0.273
E30 Disorders of puberty, not elsewhere classified
0.000 0.727 0.273
C79.2 Secondary malignant neoplasm of skin
0.000 0.728 0.272
E11.1 With ketoacidosis
0.000 0.728 0.272
E22 Hyperfunction of pituitary gland
0.000 0.732 0.268
C77.5 Intrapelvic lymph nodes
0.000 0.733 0.267
E25 Adrenogenital disorders
0.000 0.736 0.264
C76.3 Pelvis
0.000 0.736 0.264
E11.8 With unspecified complications
0.000 0.740 0.260
E11.7 With multiple complications
0.000 0.742 0.258
E20 Hypoparathyroidism
0.000 0.745 0.255
E27.8 Other specified disorders of adrenal gland
0.000 0.747 0.253
E27.5 Adrenomedullary hyperfunction
0.000 0.747 0.253
E27.0 Other adrenocortical overactivity
0.000 0.747 0.253
C76.8 Overlapping lesion of other and ill-defined sites
0.000 0.748 0.252
C76.7 Other ill-defined sites
0.000 0.748 0.252
C76.5 Lower limb
0.000 0.748 0.252
C76.4 Upper limb
0.000 0.748 0.252
E23 Hypofunction and other disorders of pituitary gland
0.000 0.749 0.251
C76.0 Head, face and neck
0.000 0.755 0.245
E24 Cushing's syndrome
0.000 0.756 0.244
E29 Testicular dysfunction
0.000 0.756 0.244
C76.2 Abdomen
0.000 0.757 0.243
E27.2 Addisonian crisis
0.000 0.758 0.241
E44.1 Mild protein-energy malnutrition
0.000 0.759 0.241
E44.0 Moderate protein-energy malnutrition
0.000 0.759 0.241
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.000 0.762 0.238
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.000 0.763 0.237
E34 Other endocrine disorders
0.000 0.763 0.237
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.767 0.233
E11.4 With neurological complications
0.000 0.769 0.231
E61 Deficiency of other nutrient elements
0.001 0.770 0.230
E22.1 Hyperprolactinaemia
0.000 0.773 0.227
E11.0 With coma
0.000 0.773 0.227
E11.5 With peripheral circulatory complications
0.000 0.777 0.223
E28 Ovarian dysfunction
0.000 0.778 0.222
C78.7 Secondary malignant neoplasm of liver
0.000 0.780 0.220
C79.8 Secondary malignant neoplasm of other specified sites
0.000 0.780 0.220
C80.9 Malignant neoplasm, unspecified
0.000 0.782 0.217
C76.1 Thorax
0.000 0.784 0.215
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.000 0.794 0.206
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.795 0.205
E26.0 Primary hyperaldosteronism
0.000 0.797 0.203
E26.9 Hyperaldosteronism, unspecified
0.000 0.801 0.199
E26.8 Other hyperaldosteronism
0.000 0.801 0.199
E26.1 Secondary hyperaldosteronism
0.000 0.801 0.199
E34.0 Carcinoid syndrome
0.000 0.802 0.198
K90.8 Other intestinal malabsorption
0.001 0.802 0.197
E30.9 Disorder of puberty, unspecified
0.000 0.804 0.196
E30.8 Other disorders of puberty
0.000 0.804 0.196
E30.1 Precocious puberty
0.000 0.804 0.196
E30.0 Delayed puberty
0.000 0.804 0.196
E31.9 Polyglandular dysfunction, unspecified
0.000 0.804 0.196
E31.8 Other polyglandular dysfunction
0.000 0.804 0.196
E31.1 Polyglandular hyperfunction
0.000 0.804 0.196
E31.0 Autoimmune polyglandular failure
0.000 0.804 0.196
E32.9 Disease of thymus, unspecified
0.000 0.804 0.196
E32.8 Other diseases of thymus
0.000 0.804 0.196
E32.1 Abscess of thymus
0.000 0.804 0.196
E32.0 Persistent hyperplasia of thymus
0.000 0.804 0.196
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.804 0.196
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.804 0.196
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.804 0.196
E46 Unspecified protein-energy malnutrition
0.001 0.806 0.194
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.808 0.192
E22.8 Other hyperfunction of pituitary gland
0.000 0.808 0.192
E25.9 Adrenogenital disorder, unspecified
0.000 0.810 0.189
E25.8 Other adrenogenital disorders
0.000 0.810 0.189
E20.8 Other hypoparathyroidism
0.000 0.817 0.183
E20.1 Pseudohypoparathyroidism
0.000 0.817 0.183
E20.0 Idiopathic hypoparathyroidism
0.000 0.817 0.183
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.819 0.181
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.819 0.180
E23.1 Drug-induced hypopituitarism
0.000 0.819 0.180
E23.6 Other disorders of pituitary gland
0.000 0.820 0.180
E23.2 Diabetes insipidus
0.000 0.820 0.180
C79.7 Secondary malignant neoplasm of adrenal gland
0.000 0.823 0.177
E24.8 Other Cushing's syndrome
0.000 0.825 0.175
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.825 0.175
E24.3 Ectopic ACTH syndrome
0.000 0.825 0.175
E24.1 Nelson's syndrome
0.000 0.825 0.175
E24.0 Pituitary-dependent Cushing's disease
0.000 0.825 0.175
E29.9 Testicular dysfunction, unspecified
0.000 0.825 0.175
E29.8 Other testicular dysfunction
0.000 0.825 0.175
E29.0 Testicular hyperfunction
0.000 0.825 0.175
E24.9 Cushing's syndrome, unspecified
0.000 0.826 0.173
E11.2 With renal complications
0.000 0.827 0.173
E23.0 Hypopituitarism
0.000 0.829 0.171
E23.7 Disorder of pituitary gland, unspecified
0.000 0.829 0.170
E34.5 Androgen resistance syndrome
0.000 0.830 0.170
E34.4 Constitutional tall stature
0.000 0.830 0.170
E34.3 Short stature, not elsewhere classified
0.000 0.830 0.170
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.830 0.170
E34.1 Other hypersecretion of intestinal hormones
0.000 0.830 0.170
E61.9 Deficiency of nutrient element, unspecified
0.001 0.835 0.165
E61.8 Deficiency of other specified nutrient elements
0.001 0.835 0.165
E61.7 Deficiency of multiple nutrient elements
0.001 0.835 0.165
E61.6 Vanadium deficiency
0.001 0.835 0.165
E61.5 Molybdenum deficiency
0.001 0.835 0.165
E61.4 Chromium deficiency
0.001 0.835 0.165
E61.3 Manganese deficiency
0.001 0.835 0.165
E61.0 Copper deficiency
0.001 0.835 0.165
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.835 0.165
E20.9 Hypoparathyroidism, unspecified
0.000 0.835 0.164
E28.3 Primary ovarian failure
0.000 0.837 0.163
E28.9 Ovarian dysfunction, unspecified
0.000 0.841 0.159
E28.8 Other ovarian dysfunction
0.000 0.841 0.159
E28.1 Androgen excess
0.000 0.841 0.159
E28.0 Oestrogen excess
0.000 0.841 0.159
E22.0 Acromegaly and pituitary gigantism
0.000 0.842 0.158
E24.2 Drug-induced Cushing's syndrome
0.000 0.851 0.149
E34.8 Other specified endocrine disorders
0.000 0.851 0.149
E29.1 Testicular hypofunction
0.000 0.854 0.146
C77.1 Intrathoracic lymph nodes
0.000 0.855 0.145
E61.2 Magnesium deficiency
0.001 0.857 0.143
E66 Obesity
0.000 0.864 0.136
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.885 0.115
E04.9 Non-toxic goitre, unspecified
0.000 0.890 0.109
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.897 0.103
E34.9 Endocrine disorder, unspecified
0.001 0.898 0.101
E28.2 Polycystic ovarian syndrome
0.000 0.899 0.101
E66.1 Drug-induced obesity
0.000 0.902 0.098
E70-E90 Metabolic disorders
0.000 0.904 0.096
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.914 0.086
E21.4 Other specified disorders of parathyroid gland
0.000 0.917 0.083
E21.2 Other hyperparathyroidism
0.000 0.917 0.083
E87.6 Hypokalaemia
0.000 0.918 0.082
C79.9 Secondary malignant neoplasm, unspecified site
0.001 0.919 0.080
E86 Volume depletion
0.000 0.921 0.079
E66.0 Obesity due to excess calories
0.000 0.922 0.078
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.923 0.077
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.924 0.075
E73 Lactose intolerance
0.000 0.925 0.075
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.928 0.072
E84 Cystic fibrosis
0.000 0.931 0.069
E79 Disorders of purine and pyrimidine metabolism
0.000 0.931 0.069
E77 Disorders of glycoprotein metabolism
0.000 0.931 0.069
E76 Disorders of glycosaminoglycan metabolism
0.000 0.931 0.069
E72 Other disorders of amino-acid metabolism
0.000 0.931 0.069

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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