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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs409558
log Bayes Factor = 21.821
Chromosome 6   position 31,708,147  (GRCh37) Explore rs409558 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.040 0.960
D69.6 Thrombocytopenia, unspecified
0.000 0.313 0.687
D69 Purpura and other haemorrhagic conditions
0.000 0.319 0.681
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.323 0.677
D69.5 Secondary thrombocytopenia
0.000 0.471 0.529
K90 Intestinal malabsorption
0.000 0.473 0.527
D69.0 Allergic purpura
0.000 0.474 0.526
D69.9 Haemorrhagic condition, unspecified
0.000 0.491 0.509
D69.8 Other specified haemorrhagic conditions
0.000 0.512 0.488
D69.2 Other nonthrombocytopenic purpura
0.000 0.512 0.488
D69.1 Qualitative platelet defects
0.000 0.512 0.488
D69.4 Other primary thrombocytopenia
0.000 0.528 0.472
K90.9 Intestinal malabsorption, unspecified
0.000 0.570 0.430
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.581 0.418
E03 Other hypothyroidism
0.000 0.593 0.407
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.594 0.405
D80-D89 Certain disorders involving the immune mechanism
0.000 0.616 0.384
D86 Sarcoidosis
0.000 0.616 0.384
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.621 0.379
K90.3 Pancreatic steatorrhoea
0.000 0.622 0.378
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.622 0.378
K90.1 Tropical sprue
0.000 0.622 0.378
D86.9 Sarcoidosis, unspecified
0.000 0.626 0.374
D86.0 Sarcoidosis of lung
0.000 0.653 0.347
D80 Immunodeficiency with predominantly antibody defects
0.000 0.657 0.343
K90.8 Other intestinal malabsorption
0.000 0.674 0.326
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.686 0.314
D84 Other immunodeficiencies
0.000 0.699 0.301
D67 Hereditary factor IX deficiency
0.000 0.700 0.300
D86.1 Sarcoidosis of lymph nodes
0.000 0.704 0.296
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.705 0.295
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.707 0.293
E03.5 Myxoedema coma
0.000 0.708 0.292
E03.4 Atrophy of thyroid (acquired)
0.000 0.708 0.292
E03.3 Postinfectious hypothyroidism
0.000 0.708 0.292
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.708 0.292
E03.1 Congenital hypothyroidism without goitre
0.000 0.708 0.292
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.708 0.292
D86.8 Sarcoidosis of other and combined sites
0.000 0.711 0.289
E03.8 Other specified hypothyroidism
0.000 0.711 0.289
D73 Diseases of spleen
0.000 0.718 0.282
D83 Common variable immunodeficiency
0.000 0.724 0.275
D82 Immunodeficiency associated with other major defects
0.000 0.724 0.275
D81 Combined immunodeficiencies
0.000 0.724 0.275
D86.3 Sarcoidosis of skin
0.000 0.725 0.275
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.725 0.275
D73.0 Hyposplenism
0.000 0.730 0.270
D66 Hereditary factor VIII deficiency
0.000 0.743 0.257
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.754 0.246
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.754 0.246
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.754 0.246
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.754 0.246
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.754 0.246
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.754 0.246
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.754 0.246
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.754 0.246
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.754 0.246
D55-D59 Haemolytic anaemias
0.000 0.757 0.243
D84.9 Immunodeficiency, unspecified
0.000 0.758 0.242
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.000 0.759 0.241
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.760 0.240
D73.5 Infarction of spleen
0.000 0.773 0.227
D84.8 Other specified immunodeficiencies
0.000 0.784 0.216
D84.1 Defects in the complement system
0.000 0.784 0.216
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.784 0.216
D74 Methaemoglobinaemia
0.000 0.788 0.211
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.788 0.211
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.788 0.211
D73.9 Disease of spleen, unspecified
0.000 0.798 0.202
D73.8 Other diseases of spleen
0.000 0.798 0.202
D73.3 Abscess of spleen
0.000 0.798 0.202
D73.2 Chronic congestive splenomegaly
0.000 0.798 0.202
D73.1 Hypersplenism
0.000 0.798 0.202
D72 Other disorders of white blood cells
0.000 0.799 0.200
D81.9 Combined immunodeficiency, unspecified
0.000 0.802 0.198
D81.8 Other combined immunodeficiencies
0.000 0.802 0.198
D81.7 Major histocompatibility complex class II deficiency
0.000 0.802 0.198
D81.6 Major histocompatibility complex class I deficiency
0.000 0.802 0.198
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.802 0.198
D81.4 Nezelof's syndrome
0.000 0.802 0.198
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.802 0.198
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.802 0.198
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.802 0.198
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.802 0.198
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.802 0.198
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.802 0.198
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.802 0.198
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.802 0.198
D82.2 Immunodeficiency with short-limbed stature
0.000 0.802 0.198
D82.1 Di George's syndrome
0.000 0.802 0.198
D82.0 Wiskott-Aldrich syndrome
0.000 0.802 0.198
D83.9 Common variable immunodeficiency, unspecified
0.000 0.802 0.198
D83.8 Other common variable immunodeficiencies
0.000 0.802 0.198
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.802 0.198
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.802 0.198
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.802 0.198
D59 Acquired haemolytic anaemia
0.000 0.804 0.196
D73.4 Cyst of spleen
0.000 0.810 0.189
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.811 0.189
D50-D53 Nutritional anaemias
0.000 0.818 0.182
D57 Sickle-cell disorders
0.000 0.825 0.174
D55 Anaemia due to enzyme disorders
0.000 0.825 0.174
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.827 0.172
D89.3 Immune reconstitution syndrome
0.000 0.827 0.172
D89.1 Cryoglobulinaemia
0.000 0.827 0.172
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.827 0.172
D59.1 Other autoimmune haemolytic anaemias
0.000 0.832 0.168
D56 Thalassaemia
0.000 0.835 0.165
D70 Agranulocytosis
0.000 0.837 0.163
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.840 0.160
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.847 0.153
D74.9 Methaemoglobinaemia, unspecified
0.000 0.848 0.152
D74.8 Other methaemoglobinaemias
0.000 0.848 0.152
D74.0 Congenital methaemoglobinaemia
0.000 0.848 0.152
D72.9 Disorder of white blood cells, unspecified
0.000 0.856 0.144
D72.0 Genetic anomalies of leukocytes
0.000 0.856 0.144
D72.8 Other specified disorders of white blood cells
0.000 0.858 0.141
D53 Other nutritional anaemias
0.000 0.859 0.141
D59.8 Other acquired haemolytic anaemias
0.000 0.859 0.140
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.859 0.140
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.859 0.140
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.859 0.140
D59.3 Haemolytic-uraemic syndrome
0.000 0.859 0.140
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.859 0.140
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.859 0.140
D60-D64 Aplastic and other anaemias
0.000 0.860 0.140
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.864 0.136
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.864 0.136
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.864 0.136
D72.1 Eosinophilia
0.000 0.864 0.136
D52 Folate deficiency anaemia
0.000 0.865 0.135
D75 Other diseases of blood and blood-forming organs
0.000 0.868 0.132
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.871 0.128
E10 Insulin-dependent diabetes mellitus
0.127 0.873 0.000
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.875 0.125
D55.8 Other anaemias due to enzyme disorders
0.000 0.875 0.125
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.875 0.125
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.875 0.125
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.875 0.125
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.875 0.125
D57.8 Other sickle-cell disorders
0.000 0.875 0.125
D57.3 Sickle-cell trait
0.000 0.875 0.125
D57.2 Double heterozygous sickling disorders
0.000 0.875 0.125
D57.1 Sickle-cell anaemia without crisis
0.000 0.875 0.125
D57.0 Sickle-cell anaemia with crisis
0.000 0.875 0.125
E10.4 With neurological complications
0.123 0.877 0.000
D56.9 Thalassaemia, unspecified
0.000 0.881 0.118
D56.8 Other thalassaemias
0.000 0.881 0.118
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.881 0.118
D56.2 Delta-beta thalassaemia
0.000 0.881 0.118
D56.1 Beta thalassaemia
0.000 0.881 0.118
D56.0 Alpha thalassaemia
0.000 0.881 0.118
D58 Other hereditary haemolytic anaemias
0.001 0.882 0.118
E10.2 With renal complications
0.117 0.883 0.000
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.883 0.117
E10.3 With ophthalmic complications
0.115 0.885 0.000
D76.3 Other histiocytosis syndromes
0.000 0.886 0.113
E10.9 Without complications
0.113 0.887 0.000
D51 Vitamin B12 deficiency anaemia
0.000 0.887 0.113
D53.9 Nutritional anaemia, unspecified
0.000 0.888 0.112
D62 Acute posthaemorrhagic anaemia
0.000 0.891 0.109
D56.3 Thalassaemia trait
0.000 0.891 0.109
E10.0 With coma
0.106 0.894 0.000
E10.5 With peripheral circulatory complications
0.103 0.897 0.000
D52.9 Folate deficiency anaemia, unspecified
0.000 0.898 0.102
D53.8 Other specified nutritional anaemias
0.000 0.899 0.101
D53.2 Scorbutic anaemia
0.000 0.899 0.101
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.899 0.101
D53.0 Protein deficiency anaemia
0.000 0.899 0.101
E10.1 With ketoacidosis
0.101 0.899 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.899 0.100
E10.6 With other specified complications
0.099 0.901 0.000
D75.2 Essential thrombocytosis
0.000 0.902 0.097
D52.8 Other folate deficiency anaemias
0.000 0.903 0.097
D52.1 Drug-induced folate deficiency anaemia
0.000 0.903 0.097
D52.0 Dietary folate deficiency anaemia
0.000 0.903 0.097
E10.7 With multiple complications
0.091 0.908 0.000
E10.8 With unspecified complications
0.087 0.912 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.914 0.086
D58.8 Other specified hereditary haemolytic anaemias
0.001 0.915 0.084
D58.2 Other haemoglobinopathies
0.001 0.915 0.084
D58.1 Hereditary elliptocytosis
0.001 0.915 0.084
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.919 0.081
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.919 0.081
D51.2 Transcobalamin II deficiency
0.000 0.919 0.081
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.919 0.081
G35 Multiple sclerosis
0.000 0.921 0.079
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.921 0.079
D75.0 Familial erythrocytosis
0.001 0.927 0.073
M45.X9 Ankylosing spondylitis (Site unspecified)
0.073 0.927 0.000
D60.9 Acquired pure red cell aplasia, unspecified
0.000 0.928 0.072
D60.8 Other acquired pure red cell aplasias
0.000 0.928 0.072
D60.1 Transient acquired pure red cell aplasia
0.000 0.928 0.072
D60.0 Chronic acquired pure red cell aplasia
0.000 0.928 0.072
D64 Other anaemias
0.000 0.934 0.066
D58.0 Hereditary spherocytosis
0.001 0.935 0.065
D61 Other aplastic anaemias
0.000 0.936 0.064
D58.9 Hereditary haemolytic anaemia, unspecified
0.001 0.938 0.062
M45 Ankylosing spondylitis
0.061 0.939 0.000
D63.0 Anaemia in neoplastic disease
0.000 0.941 0.059
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.058 0.942 0.000
D63.1 Anaemia in other chronic diseases classified elsewhere
0.000 0.943 0.057
K90-K93 Other diseases of the digestive system
0.001 0.945 0.054
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.945 0.054
E10-E14 Diabetes mellitus
0.054 0.946 0.000
D75.8 Other specified diseases of blood and blood-forming organs
0.001 0.947 0.052
D64.8 Other specified anaemias
0.000 0.951 0.049
D64.4 Congenital dyserythropoietic anaemia
0.000 0.952 0.048
D64.3 Other sideroblastic anaemias
0.000 0.952 0.048
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.952 0.048
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.952 0.048
D64.0 Hereditary sideroblastic anaemia
0.000 0.952 0.048
M45.X2 Ankylosing spondylitis (Cervical region)
0.048 0.952 0.000
D61.8 Other specified aplastic anaemias
0.000 0.954 0.046
D61.3 Idiopathic aplastic anaemia
0.000 0.954 0.046
D61.2 Aplastic anaemia due to other external agents
0.000 0.954 0.046
D61.0 Constitutional aplastic anaemia
0.000 0.954 0.046
I83 Varicose veins of lower extremities
0.000 0.954 0.046
D75.1 Secondary polycythaemia
0.000 0.955 0.045
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.044 0.956 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.044 0.956 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.044 0.956 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.044 0.956 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.044 0.956 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.044 0.956 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.044 0.956 0.000
D61.1 Drug-induced aplastic anaemia
0.000 0.957 0.043
E13 Other specified diabetes mellitus
0.041 0.959 0.000
E14 Unspecified diabetes mellitus
0.040 0.960 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.001 0.960 0.039
E12 Malnutrition-related diabetes mellitus
0.039 0.961 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.037 0.963 0.000
D50 Iron deficiency anaemia
0.000 0.964 0.036
E14.8 With unspecified complications
0.035 0.965 0.000
E11 Non-insulin-dependent diabetes mellitus
0.034 0.966 0.000
M06.9 Rheumatoid arthritis, unspecified
0.034 0.966 0.000
E14.6 With other specified complications
0.034 0.966 0.000
E11.4 With neurological complications
0.034 0.966 0.000
M06 Other rheumatoid arthritis
0.034 0.966 0.000
Q61 Cystic kidney disease
0.033 0.967 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.967 0.033
E14.5 With peripheral circulatory complications
0.032 0.968 0.000
Q61.0 Congenital single renal cyst
0.032 0.968 0.000
E14.4 With neurological complications
0.032 0.968 0.000
E13.9 Without complications
0.031 0.969 0.000
E11.0 With coma
0.031 0.969 0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.000 0.970 0.030
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.030 0.970 0.000
D63.8 Anaemia in other chronic diseases classified elsewhere
0.000 0.970 0.030
Q61.3 Polycystic kidney, unspecified
0.029 0.971 0.000
E13.8 With unspecified complications
0.029 0.971 0.000
E13.7 With multiple complications
0.029 0.971 0.000
E13.6 With other specified complications
0.029 0.971 0.000
E13.5 With peripheral circulatory complications
0.029 0.971 0.000
E13.4 With neurological complications
0.029 0.971 0.000
E13.3 With ophthalmic complications
0.029 0.971 0.000
E13.2 With renal complications
0.029 0.971 0.000
E13.1 With ketoacidosis
0.029 0.971 0.000
E13.0 With coma
0.029 0.971 0.000
M06.0 Seronegative rheumatoid arthritis
0.029 0.971 0.000
E14.1 With ketoacidosis
0.029 0.971 0.000
E14.7 With multiple complications
0.029 0.971 0.000
E14.2 Withrenal complications
0.029 0.971 0.000
E14.0 With coma
0.029 0.971 0.000
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.001 0.971 0.028
K93.1 Megacolon in Chagas' disease
0.001 0.971 0.028
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.001 0.971 0.028
D68 Other coagulation defects
0.002 0.971 0.027
M05-M14 Inflammatory polyarthropathies
0.029 0.971 0.000
Q60-Q64 Congenital malformations of the urinary system
0.028 0.972 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.028 0.972 0.000
M06.3 Rheumatoid nodule
0.028 0.972 0.000
E12.9 Without complications
0.028 0.972 0.000
E12.8 With unspecified complications
0.028 0.972 0.000
E12.7 With multiple complications
0.028 0.972 0.000
E12.6 With other specified complications
0.028 0.972 0.000
E12.5 With peripheral circulatory complications
0.028 0.972 0.000
E12.4 With neurological complications
0.028 0.972 0.000
E12.3 With ophthalmic complications
0.028 0.972 0.000
E12.2 With renal complications
0.028 0.972 0.000
E12.1 With ketoacidosis
0.028 0.972 0.000
E12.0 With coma
0.028 0.972 0.000
Q61.2 Polycystic kidney, adult type
0.027 0.973 0.000
M06.4 Inflammatory polyarthropathy
0.027 0.973 0.000
Q61.4 Renal dysplasia
0.027 0.973 0.000
M07 Psoriatic and enteropathic arthropathies
0.027 0.973 0.000
I83.1 Varicose veins of lower extremities with inflammation
0.000 0.973 0.026
Q61.5 Medullary cystic kidney
0.026 0.974 0.000
D50.1 Sideropenic dysphagia
0.000 0.974 0.026
M07.3 Other psoriatic arthropathies
0.026 0.974 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.026 0.974 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.025 0.975 0.000
K92.1 Melaena
0.000 0.975 0.025
E11.7 With multiple complications
0.025 0.975 0.000
K92 Other diseases of digestive system
0.001 0.975 0.024
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.025 0.975 0.000
I83.0 Varicose veins of lower extremities with ulcer
0.000 0.975 0.024
M06.8 Other specified rheumatoid arthritis
0.024 0.976 0.000
M06.2 Rheumatoid bursitis
0.024 0.976 0.000
M06.1 Adult-onset Still's disease
0.024 0.976 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.024 0.976 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.024 0.976 0.000
E11.1 With ketoacidosis
0.024 0.976 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.024 0.976 0.000
E11.5 With peripheral circulatory complications
0.024 0.976 0.000
M14 Arthropathies in other diseases classified elsewhere
0.024 0.976 0.000
Q61.9 Cystic kidney disease, unspecified
0.024 0.976 0.000
Q61.8 Other cystic kidney diseases
0.024 0.976 0.000
Q61.1 Polycystic kidney, infantile type
0.024 0.976 0.000
G36 Other acute disseminated demyelination
0.000 0.976 0.024
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.024 0.976 0.000
E11.6 With other specified complications
0.023 0.977 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.023 0.977 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.023 0.977 0.000
M11 Other crystal arthropathies
0.023 0.977 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.023 0.977 0.000
M06.34 Rheumatoid nodule (Hand)
0.023 0.977 0.000
E14.3 With ophthalmic complications
0.023 0.977 0.000
G37 Other demyelinating diseases of central nervous system
0.000 0.977 0.023
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.023 0.977 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.023 0.977 0.000
M45-M49 Spondylopathies
0.022 0.978 0.000
Q38.7 Pharyngeal pouch
0.022 0.978 0.000
E11.2 With renal complications
0.022 0.978 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.022 0.978 0.000
Q64 Other congenital malformations of urinary system
0.022 0.978 0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.022 0.978 0.000
D68.6 Other Thrombophilia
0.001 0.978 0.021
E11.8 With unspecified complications
0.022 0.978 0.000
E00-E07 Disorders of thyroid gland
0.000 0.978 0.022
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.978 0.022
Q65 Congenital deformities of hip
0.021 0.979 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.021 0.979 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.021 0.979 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.021 0.979 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.021 0.979 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.021 0.979 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.021 0.979 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.021 0.979 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.021 0.979 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.021 0.979 0.000
Q63 Other congenital malformations of kidney
0.021 0.979 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.021 0.979 0.000
D68.4 Acquired coagulation factor deficiency
0.001 0.979 0.019
M12 Other specific arthropathies
0.021 0.979 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.021 0.979 0.000
M08 Juvenile arthritis
0.021 0.979 0.000
Q35-Q37 Cleft lip and cleft palate
0.021 0.979 0.000
M14.6 Neuropathic arthropathy
0.021 0.979 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.020 0.979 0.000
M05 Seropositive rheumatoid arthritis
0.020 0.980 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.020 0.980 0.000
M06.38 Rheumatoid nodule (Other)
0.020 0.980 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.020 0.980 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.020 0.980 0.000
M06.33 Rheumatoid nodule (Forearm)
0.020 0.980 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.020 0.980 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.020 0.980 0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.020 0.980 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.020 0.980 0.000
Q40 Other congenital malformations of upper alimentary tract
0.020 0.980 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.020 0.980 0.000
M06.48 Inflammatory polyarthropathy (Other)
0.020 0.980 0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.020 0.980 0.000
M06.46 Inflammatory polyarthropathy (Lower leg)
0.020 0.980 0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.020 0.980 0.000
M06.44 Inflammatory polyarthropathy (Hand)
0.020 0.980 0.000
M06.43 Inflammatory polyarthropathy (Forearm)
0.020 0.980 0.000
M06.42 Inflammatory polyarthropathy (Upper arm)
0.020 0.980 0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.020 0.980 0.000
M07.6 Other enteropathic arthropathies
0.019 0.980 0.000
M07.5 Arthropathy in ulcerative colitis
0.019 0.980 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.019 0.980 0.000
M07.2 Psoriatic spondylitis
0.019 0.980 0.000
M07.1 Arthritis mutilans
0.019 0.980 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.019 0.980 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.019 0.980 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.019 0.981 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.019 0.981 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.019 0.981 0.000
M96.0 Pseudarthrosis after fusion or arthrodesis
0.019 0.981 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.019 0.981 0.000
Q39 Congenital malformations of oesophagus
0.019 0.981 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.019 0.981 0.000
M07.38 Other psoriatic arthropathies (Other)
0.019 0.981 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.019 0.981 0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.019 0.981 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.019 0.981 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.019 0.981 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.019 0.981 0.000
M07.31 Other psoriatic arthropathies (Shoulder region)
0.019 0.981 0.000
Q65.8 Other congenital deformities of hip
0.019 0.981 0.000
Q80-Q89 Other congenital malformations
0.019 0.981 0.000
D68.1 Hereditary factor XI deficiency
0.001 0.981 0.017
Q65.2 Congenital dislocation of hip, unspecified
0.018 0.981 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.018 0.981 0.000
M11.9 Crystal arthropathy, unspecified
0.018 0.982 0.000
M49 Spondylopathies in diseases classified elsewhere
0.018 0.982 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.018 0.982 0.000
M06.19 Adult-onset Still's disease (Site unspecified)
0.018 0.982 0.000
M06.18 Adult-onset Still's disease (Other)
0.018 0.982 0.000
M06.17 Adult-onset Still's disease (Ankle and foot)
0.018 0.982 0.000
M06.16 Adult-onset Still's disease (Lower leg)
0.018 0.982 0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.018 0.982 0.000
M06.14 Adult-onset Still's disease (Hand)
0.018 0.982 0.000
M06.13 Adult-onset Still's disease (Forearm)
0.018 0.982 0.000
M06.12 Adult-onset Still's disease (Upper arm)
0.018 0.982 0.000
M06.11 Adult-onset Still's disease (Shoulder region)
0.018 0.982 0.000
M06.10 Adult-onset Still's disease (Multiple sites)
0.018 0.982 0.000
M06.29 Rheumatoid bursitis (Site unspecified)
0.018 0.982 0.000
M06.28 Rheumatoid bursitis (Other)
0.018 0.982 0.000
M06.27 Rheumatoid bursitis (Ankle and foot)
0.018 0.982 0.000
M06.26 Rheumatoid bursitis (Lower leg)
0.018 0.982 0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.018 0.982 0.000
M06.24 Rheumatoid bursitis (Hand)
0.018 0.982 0.000
M06.23 Rheumatoid bursitis (Forearm)
0.018 0.982 0.000
M06.22 Rheumatoid bursitis (Upper arm)
0.018 0.982 0.000
M06.21 Rheumatoid bursitis (Shoulder region)
0.018 0.982 0.000
M06.20 Rheumatoid bursitis (Multiple sites)
0.018 0.982 0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.018 0.982 0.000
M06.88 Other specified rheumatoid arthritis (Other)
0.018 0.982 0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.018 0.982 0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.018 0.982 0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.018 0.982 0.000
M06.84 Other specified rheumatoid arthritis (Hand)
0.018 0.982 0.000
M06.83 Other specified rheumatoid arthritis (Forearm)
0.018 0.982 0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.018 0.982 0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.018 0.982 0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.018 0.982 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.001 0.982 0.016
Q64.7 Other congenital malformations of bladder and urethra
0.018 0.982 0.000
Q45 Other congenital malformations of digestive system
0.017 0.982 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.017 0.982 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.017 0.982 0.000
D68.2 Hereditary deficiency of other clotting factors
0.001 0.982 0.017
Q60 Renal agenesis and other reduction defects of kidney
0.017 0.982 0.000
M14.8 Arthropathies in other specified diseases classified elsewhere
0.017 0.983 0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.017 0.983 0.000
M14.4 Arthropathy in amyloidosis
0.017 0.983 0.000
M14.3 Lipoid dermatoarthritis
0.017 0.983 0.000
M14.2 Diabetic arthropathy
0.017 0.983 0.000
M14.1 Crystal arthropathy in other metabolic disorders
0.017 0.983 0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.017 0.983 0.000
M11.2 Other chondrocalcinosis
0.017 0.983 0.000
G36.9 Acute disseminated demyelination, unspecified
0.000 0.983 0.017
G36.8 Other specified acute disseminated demyelination
0.000 0.983 0.017
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.983 0.017
G36.0 Neuromyelitis optica [Devic]
0.000 0.983 0.017
Q66 Congenital deformities of feet
0.017 0.983 0.000
Q40.3 Congenital malformation of stomach, unspecified
0.017 0.983 0.000
M67 Other disorders of synovium and tendon
0.017 0.983 0.000
Q63.2 Ectopic kidney
0.017 0.983 0.000
L43.9 Lichen planus, unspecified
0.017 0.983 0.000
D61.9 Aplastic anaemia, unspecified
0.001 0.983 0.016
Q63.1 Lobulated, fused and horseshoe kidney
0.017 0.983 0.000
M11.8 Other specified crystal arthropathies
0.017 0.983 0.000
M11.1 Familial chondrocalcinosis
0.017 0.983 0.000
M11.0 Hydroxyapatite deposition disease
0.017 0.983 0.000
Q38.8 Other congenital malformations of pharynx
0.017 0.983 0.000
Q38.6 Other congenital malformations of mouth
0.017 0.983 0.000
Q38.5 Congenital malformations of palate, not elsewhere classified
0.017 0.983 0.000
Q38.4 Congenital malformations of salivary glands and ducts
0.017 0.983 0.000
Q38.3 Other congenital malformations of tongue
0.017 0.983 0.000
Q38.2 Macroglossia
0.017 0.983 0.000
Q38.1 Ankyloglossia
0.017 0.983 0.000
Q38.0 Congenital malformations of lips, not elsewhere classified
0.017 0.983 0.000
M65-M68 Disorders of synovium and tendon
0.017 0.983 0.000
G37.5 Concentric sclerosis [Balo]
0.000 0.983 0.016
G37.4 Subacute necrotising myelitis
0.000 0.983 0.016
G37.2 Central pontine myelinolysis
0.000 0.983 0.016
G37.1 Central demyelination of corpus callosum
0.000 0.983 0.016
G37.0 Diffuse sclerosis
0.000 0.983 0.016
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.016 0.983 0.000
Q75 Other congenital malformations of skull and face bones
0.016 0.983 0.000
Q74 Other congenital malformations of limb(s)
0.016 0.983 0.000
Q73 Reduction defects of unspecified limb
0.016 0.983 0.000
Q72 Reduction defects of lower limb
0.016 0.983 0.000
Q71 Reduction defects of upper limb
0.016 0.983 0.000
Q70 Syndactyly
0.016 0.983 0.000
Q69 Polydactyly
0.016 0.983 0.000
Q68 Other congenital musculoskeletal deformities
0.016 0.983 0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest
0.016 0.983 0.000
J15.7 Pneumonia due to Mycoplasma pneumoniae
0.017 0.983 0.000
Q37 Cleft palate with cleft lip
0.016 0.983 0.000
M00-M03 Infectious arthropathies
0.017 0.983 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.983 0.016
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.984 0.016
J45.9 Asthma, unspecified
0.000 0.984 0.016
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.016 0.984 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.016 0.984 0.000
Q35 Cleft palate
0.016 0.984 0.000
Q78 Other osteochondrodysplasias
0.016 0.984 0.000
Q64.9 Congenital malformation of urinary system, unspecified
0.016 0.984 0.000
Q64.8 Other specified congenital malformations of urinary system
0.016 0.984 0.000
Q64.6 Congenital diverticulum of bladder
0.016 0.984 0.000
Q64.5 Congenital absence of bladder and urethra
0.016 0.984 0.000
Q64.4 Malformation of urachus
0.016 0.984 0.000
Q64.3 Other atresia and stenosis of urethra and bladder neck
0.016 0.984 0.000
Q64.2 Congenital posterior urethral valves
0.016 0.984 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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