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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs412657
log Bayes Factor = 242.2
Chromosome 6   position 32,211,085  (GRCh37) Explore rs412657 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
N00-N08 Glomerular diseases
0.999 0.001 0.000
M05 Seropositive rheumatoid arthritis
0.000 0.001 0.998
M05-M14 Inflammatory polyarthropathies
0.001 0.002 0.997
N04 Nephrotic syndrome
0.998 0.002 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.998 0.002 0.000
E10.1 With ketoacidosis
0.997 0.003 0.000
D60-D64 Aplastic and other anaemias
0.997 0.003 0.000
N05 Unspecified nephritic syndrome
0.996 0.004 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.004 0.996
H00.1 Chalazion
0.000 0.005 0.995
M06.3 Rheumatoid nodule
0.000 0.006 0.994
D64 Other anaemias
0.993 0.007 0.000
N04.9 Unspecified
0.991 0.009 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.990 0.010 0.000
D64.9 Anaemia, unspecified
0.990 0.010 0.000
D80-D89 Certain disorders involving the immune mechanism
0.989 0.011 0.000
E14 Unspecified diabetes mellitus
0.989 0.011 0.000
D50-D53 Nutritional anaemias
0.987 0.013 0.000
E16 Other disorders of pancreatic internal secretion
0.984 0.016 0.000
E07 Other disorders of thyroid
0.983 0.017 0.000
D86 Sarcoidosis
0.982 0.018 0.000
# Top node
0.981 0.019 0.000
Chapter XIV Diseases of the genitourinary system
0.977 0.023 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.024 0.976
K90 Intestinal malabsorption
0.976 0.024 0.000
N18 Chronic renal failure
0.975 0.025 0.000
N17-N19 Renal failure
0.974 0.026 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.027 0.973
D50 Iron deficiency anaemia
0.973 0.027 0.000
N05.9 Unspecified
0.970 0.030 0.000
E16.2 Hypoglycaemia, unspecified
0.970 0.030 0.000
K90.9 Intestinal malabsorption, unspecified
0.968 0.032 0.000
E14.3 With ophthalmic complications
0.968 0.032 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.967 0.033 0.000
M06.34 Rheumatoid nodule (Hand)
0.000 0.033 0.967
N05.2 Diffuse membranous glomerulonephritis
0.966 0.034 0.000
E83.1 Disorders of iron metabolism
0.000 0.038 0.962
E10.4 With neurological complications
0.961 0.039 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.943 0.041 0.016
D61 Other aplastic anaemias
0.956 0.044 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.955 0.045 0.000
M17.1 Other primary gonarthrosis
0.953 0.047 0.000
D86.9 Sarcoidosis, unspecified
0.951 0.049 0.000
M15-M19 Arthrosis
0.950 0.050 0.000
N18.2 Chronic kidney disease, stage 2
0.950 0.050 0.000
E20-E35 Disorders of other endocrine glands
0.949 0.051 0.000
M18 Arthrosis of first carpometacarpal joint
0.947 0.053 0.000
M17 Gonarthrosis [arthrosis of knee]
0.946 0.054 0.000
N18.3 Chronic kidney disease, stage 3
0.944 0.056 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.057 0.943
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.941 0.059 0.000
E07.9 Disorder of thyroid, unspecified
0.939 0.061 0.000
Q60-Q64 Congenital malformations of the urinary system
0.937 0.063 0.000
M20-M25 Other joint disorders
0.918 0.068 0.014
D50.9 Iron deficiency anaemia, unspecified
0.928 0.072 0.000
N04.2 Diffuse membranous glomerulonephritis
0.927 0.073 0.000
D61.9 Aplastic anaemia, unspecified
0.924 0.076 0.000
M35 Other systemic involvement of connective tissue
0.905 0.082 0.013
E10.2 With renal complications
0.917 0.083 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.916 0.084 0.000
E06 Thyroiditis
0.915 0.085 0.000
I77 Other disorders of arteries and arterioles
0.913 0.087 0.000
I77.1 Stricture of artery
0.911 0.089 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.907 0.093 0.000
M35.0 Sicca syndrome [Sjogren]
0.905 0.095 0.000
E07.8 Other specified disorders of thyroid
0.903 0.096 0.000
E10.5 With peripheral circulatory complications
0.902 0.098 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.103 0.897
Chapter IX Diseases of the circulatory system
0.888 0.112 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.881 0.119 0.000
D86.8 Sarcoidosis of other and combined sites
0.880 0.120 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.120 0.880
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.124 0.876
E24 Cushing's syndrome
0.872 0.128 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.871 0.129 0.000
E27 Other disorders of adrenal gland
0.869 0.131 0.000
N04.1 Focal and segmental glomerular lesions
0.868 0.132 0.000
D51 Vitamin B12 deficiency anaemia
0.867 0.133 0.000
Q61 Cystic kidney disease
0.863 0.137 0.000
M60-M63 Disorders of muscles
0.855 0.137 0.007
M33 Dermatopolymyositis
0.857 0.138 0.005
M23 Internal derangement of knee
0.859 0.141 0.000
E27.1 Primary adrenocortical insufficiency
0.854 0.146 0.000
E14.1 With ketoacidosis
0.848 0.152 0.000
N03 Chronic nephritic syndrome
0.847 0.153 0.000
D50.8 Other iron deficiency anaemias
0.846 0.154 0.000
M23.3 Other meniscus derangements
0.843 0.157 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.840 0.159 0.000
N05.1 Focal and segmental glomerular lesions
0.835 0.165 0.000
E14.4 With neurological complications
0.831 0.169 0.000
D83 Common variable immunodeficiency
0.830 0.170 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.828 0.172 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.827 0.173 0.000
Q63 Other congenital malformations of kidney
0.827 0.173 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.173 0.827
I71 Aortic aneurysm and dissection
0.825 0.175 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.175 0.825
Q50-Q56 Congenital malformations of genital organs
0.825 0.175 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.823 0.177 0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis
0.823 0.177 0.000
I10-I15 Hypertensive diseases
0.822 0.178 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.821 0.179 0.000
E16.1 Other hypoglycaemia
0.817 0.183 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.809 0.191 0.000
E14.8 With unspecified complications
0.806 0.194 0.000
N18.1 Chronic kidney disease, stage 1
0.804 0.196 0.000
N18.9 Chronic renal failure, unspecified
0.803 0.197 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.200 0.800
E28 Ovarian dysfunction
0.799 0.201 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.798 0.202 0.000
M22 Disorders of patella
0.795 0.204 0.001
D86.0 Sarcoidosis of lung
0.795 0.205 0.000
M35.7 Hypermobility syndrome
0.788 0.207 0.005
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.788 0.212 0.000
I74 Arterial embolism and thrombosis
0.787 0.213 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.786 0.214 0.000
D64.8 Other specified anaemias
0.786 0.214 0.000
M24 Other specific joint derangements
0.785 0.215 0.000
E24.2 Drug-induced Cushing's syndrome
0.785 0.215 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.217 0.783
Q38 Other congenital malformations of tongue, mouth and pharynx
0.783 0.217 0.000
I12 Hypertensive renal disease
0.783 0.217 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.781 0.219 0.000
M60 Myositis
0.777 0.220 0.003
E13 Other specified diabetes mellitus
0.779 0.220 0.000
M23.0 Cystic meniscus
0.777 0.223 0.000
M33.2 Polymyositis
0.775 0.223 0.002
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.224 0.776
E10.0 With coma
0.776 0.224 0.000
K90.8 Other intestinal malabsorption
0.775 0.225 0.000
N02 Recurrent and persistent haematuria
0.774 0.226 0.000
N18.0 End-stage renal disease
0.773 0.227 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.772 0.228 0.000
E06.9 Thyroiditis, unspecified
0.768 0.232 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.767 0.233 0.000
I12.9 Hypertensive renal disease without renal failure
0.766 0.234 0.000
D86.3 Sarcoidosis of skin
0.763 0.237 0.000
M15 Polyarthrosis
0.762 0.238 0.000
M17.0 Primary gonarthrosis, bilateral
0.760 0.240 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.758 0.242 0.000
E10.7 With multiple complications
0.757 0.243 0.000
M14 Arthropathies in other diseases classified elsewhere
0.000 0.243 0.757
N18.4 Chronic kidney disease, stage 4
0.757 0.243 0.000
Q61.2 Polycystic kidney, adult type
0.753 0.247 0.000
E29 Testicular dysfunction
0.748 0.251 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.748 0.252 0.000
N25-N29 Other disorders of kidney and ureter
0.748 0.252 0.000
E06.3 Autoimmune thyroiditis
0.748 0.252 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.254 0.746
Q50.4 Embryonic cyst of Fallopian tube
0.738 0.262 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.262 0.738
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.737 0.263 0.000
D61.0 Constitutional aplastic anaemia
0.737 0.263 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.263 0.737
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.263 0.737
M12 Other specific arthropathies
0.000 0.263 0.736
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.736 0.264 0.000
M05.8 Other seropositive rheumatoid arthritis
0.000 0.264 0.736
N02.2 Diffuse membranous glomerulonephritis
0.736 0.264 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.732 0.268 0.000
I77.0 Arteriovenous fistula, acquired
0.732 0.268 0.000
M33.1 Other dermatomyositis
0.729 0.269 0.002
Q60.2 Renal agenesis, unspecified
0.730 0.270 0.000
E14.2 Withrenal complications
0.728 0.272 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.728 0.272 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.272 0.728
I71.0 Dissection of aorta [any part]
0.728 0.272 0.000
E31 Polyglandular dysfunction
0.727 0.273 0.000
E24.0 Pituitary-dependent Cushing's disease
0.726 0.274 0.000
D50.1 Sideropenic dysphagia
0.725 0.275 0.000
Q00-Q07 Congenital malformations of the nervous system
0.725 0.275 0.000
M23.5 Chronic instability of knee
0.725 0.275 0.000
N00 Acute nephritic syndrome
0.724 0.276 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.277 0.723
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.720 0.280 0.000
N08.5 Glomerular disorders in systemic connective tissue disorders
0.719 0.281 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.718 0.282 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
N07 Hereditary nephropathy, not elsewhere classified
0.716 0.283 0.000
N06 Isolated proteinuria with specified morphological lesion
0.716 0.283 0.000
N01 Rapidly progressive nephritic syndrome
0.716 0.283 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.284 0.716
M05.1 Rheumatoid lung disease
0.000 0.284 0.716
M05.0 Felty's syndrome
0.000 0.284 0.716
D83.9 Common variable immunodeficiency, unspecified
0.716 0.284 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.001 0.284 0.715
M08 Juvenile arthritis
0.001 0.284 0.715
N04.8 Other
0.715 0.284 0.000
N04.7 Diffuse crescentic glomerulonephritis
0.715 0.284 0.000
N04.6 Dense deposit disease
0.715 0.284 0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis
0.715 0.284 0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis
0.715 0.284 0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis
0.715 0.284 0.000
Q61.9 Cystic kidney disease, unspecified
0.715 0.285 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.715 0.285 0.000
M32 Systemic lupus erythematosus
0.706 0.286 0.008
N05.6 Dense deposit disease
0.714 0.286 0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis
0.714 0.286 0.000
N05.0 Minor glomerular abnormality
0.714 0.286 0.000
N18.5 Chronic kidney disease, stage 5
0.714 0.286 0.000
D86.1 Sarcoidosis of lymph nodes
0.714 0.286 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.287 0.713
M06.38 Rheumatoid nodule (Other)
0.000 0.287 0.713
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.287 0.713
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.287 0.713
M06.33 Rheumatoid nodule (Forearm)
0.000 0.287 0.713
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.287 0.713
D64.4 Congenital dyserythropoietic anaemia
0.712 0.288 0.000
D64.3 Other sideroblastic anaemias
0.712 0.288 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.712 0.288 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.712 0.288 0.000
D64.0 Hereditary sideroblastic anaemia
0.712 0.288 0.000
E06.1 Subacute thyroiditis
0.712 0.288 0.000
E03.8 Other specified hypothyroidism
0.712 0.288 0.000
N03.1 Focal and segmental glomerular lesions
0.711 0.289 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.711 0.289 0.000
E15 Nondiabetic hypoglycaemic coma
0.710 0.290 0.000
D81 Combined immunodeficiencies
0.709 0.291 0.000
E14.7 With multiple complications
0.709 0.291 0.000
E14.0 With coma
0.709 0.291 0.000
D82 Immunodeficiency associated with other major defects
0.707 0.292 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.697 0.294 0.009
E16.9 Disorder of pancreatic internal secretion, unspecified
0.705 0.295 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.705 0.295 0.000
E16.4 Abnormal secretion of gastrin
0.705 0.295 0.000
E16.3 Increased secretion of glucagon
0.705 0.295 0.000
E22 Hyperfunction of pituitary gland
0.705 0.295 0.000
E07.1 Dyshormogenetic goitre
0.704 0.295 0.000
E07.0 Hypersecretion of calcitonin
0.704 0.295 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.296 0.704
E06.5 Other chronic thyroiditis
0.704 0.296 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.703 0.297 0.000
M60.9 Myositis, unspecified
0.701 0.297 0.002
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases
0.702 0.298 0.000
I77.2 Rupture of artery
0.701 0.299 0.000
E28.3 Primary ovarian failure
0.701 0.299 0.000
K90.3 Pancreatic steatorrhoea
0.700 0.300 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.700 0.300 0.000
K90.1 Tropical sprue
0.700 0.300 0.000
N18.8 Other chronic renal failure
0.699 0.301 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.699 0.301 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.698 0.302 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.697 0.302 0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.696 0.304 0.000
D53 Other nutritional anaemias
0.695 0.305 0.000
M22.9 Disorder of patella, unspecified
0.691 0.308 0.001
Q60.0 Renal agenesis, unilateral
0.691 0.309 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.689 0.311 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.312 0.688
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.688 0.312 0.000
Q63.2 Ectopic kidney
0.687 0.313 0.000
Q63.0 Accessory kidney
0.687 0.313 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.687 0.313 0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis
0.687 0.313 0.000
D80 Immunodeficiency with predominantly antibody defects
0.687 0.313 0.000
Q38.7 Pharyngeal pouch
0.686 0.314 0.000
D61.8 Other specified aplastic anaemias
0.685 0.314 0.000
D61.3 Idiopathic aplastic anaemia
0.685 0.314 0.000
D61.2 Aplastic anaemia due to other external agents
0.685 0.314 0.000
N08.8 Glomerular disorders in other diseases classified elsewhere
0.685 0.315 0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism
0.685 0.315 0.000
N08.1 Glomerular disorders in neoplastic diseases
0.685 0.315 0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere
0.685 0.315 0.000
Q80-Q89 Other congenital malformations
0.684 0.316 0.000
E03.1 Congenital hypothyroidism without goitre
0.683 0.316 0.000
N28.9 Disorder of kidney and ureter, unspecified
0.684 0.316 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.681 0.318 0.000
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)
0.681 0.319 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.681 0.319 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.680 0.320 0.000
E32 Diseases of thymus
0.680 0.320 0.000
E30 Disorders of puberty, not elsewhere classified
0.680 0.320 0.000
E25 Adrenogenital disorders
0.679 0.321 0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.679 0.321 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.679 0.321 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.679 0.321 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.679 0.321 0.000
E14.5 With peripheral circulatory complications
0.678 0.322 0.000
M15.2 Bouchard's nodes (with arthropathy)
0.675 0.325 0.000
Q63.9 Congenital malformation of kidney, unspecified
0.674 0.326 0.000
Q52 Other congenital malformations of female genitalia
0.674 0.326 0.000
I70 Atherosclerosis
0.669 0.330 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.331 0.669
M22.2 Patellofemoral disorders
0.669 0.331 0.000
D52 Folate deficiency anaemia
0.669 0.331 0.000
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.000 0.331 0.669
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)
0.667 0.333 0.000
H00 Hordeolum and chalazion
0.071 0.333 0.595
Q35-Q37 Cleft lip and cleft palate
0.666 0.334 0.000
M62 Other disorders of muscle
0.662 0.334 0.004
D55-D59 Haemolytic anaemias
0.665 0.335 0.000
Q61.3 Polycystic kidney, unspecified
0.663 0.337 0.000
E13.9 Without complications
0.663 0.337 0.000
N03.8 Other
0.662 0.338 0.000
Q39 Congenital malformations of oesophagus
0.660 0.340 0.000
M22.8 Other disorders of patella
0.659 0.340 0.000
I11 Hypertensive heart disease
0.659 0.340 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.649 0.341 0.009
M35.6 Relapsing panniculitis [Weber-Christian]
0.649 0.341 0.009
M35.5 Multifocal fibrosclerosis
0.649 0.341 0.009
M35.4 Diffuse (eosinophilic) fasciitis
0.649 0.341 0.009
K40.2 Bilateral inguinal hernia, without obstruction or gangrene
0.000 0.343 0.657
E06.4 Drug-induced thyroiditis
0.656 0.344 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.656 0.344 0.000
E06.0 Acute thyroiditis
0.656 0.344 0.000
I77.5 Necrosis of artery
0.654 0.345 0.000
I77.4 Coeliac artery compression syndrome
0.654 0.345 0.000
I77.3 Arterial fibromuscular dysplasia
0.654 0.345 0.000
D61.1 Drug-induced aplastic anaemia
0.652 0.348 0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.652 0.348 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.650 0.350 0.000
K40 Inguinal hernia
0.001 0.350 0.649
E14.9 Without complications
0.650 0.350 0.000
E20 Hypoparathyroidism
0.649 0.351 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.646 0.354 0.000
N04.0 Minor glomerular abnormality
0.645 0.355 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.357 0.643
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.357 0.643
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.357 0.643
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.357 0.643
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.357 0.643
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.357 0.643
M05.2 Rheumatoid vasculitis
0.000 0.359 0.640
N02.3 Diffuse mesangial proliferative glomerulonephritis
0.640 0.360 0.000
M35.1 Other overlap syndromes
0.632 0.360 0.008
E03.0 Congenital hypothyroidism with diffuse goitre
0.639 0.361 0.000
E27.9 Disorder of adrenal gland, unspecified
0.639 0.361 0.000
N05.8 Other
0.637 0.363 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.637 0.363 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.635 0.365 0.001
E11 Non-insulin-dependent diabetes mellitus
0.635 0.365 0.000
M91-M94 Chondropathies
0.625 0.366 0.008
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.633 0.367 0.000
M23.06 Cystic meniscus (Other and unspecified lateral meniscus)
0.633 0.367 0.000
N17 Acute renal failure
0.632 0.368 0.000
Q61.5 Medullary cystic kidney
0.632 0.368 0.000
I00-I02 Acute rheumatic fever
0.631 0.369 0.000
E23 Hypofunction and other disorders of pituitary gland
0.630 0.370 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.629 0.371 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.629 0.371 0.000
M80-M85 Disorders of bone density and structure
0.626 0.373 0.002
M22.3 Other derangements of patella
0.626 0.373 0.001
E24.8 Other Cushing's syndrome
0.625 0.374 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.625 0.374 0.000
E24.3 Ectopic ACTH syndrome
0.625 0.374 0.000
E24.1 Nelson's syndrome
0.625 0.374 0.000
M24.7 Protrusio acetabuli
0.625 0.375 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.624 0.376 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.624 0.376 0.000
E27.5 Adrenomedullary hyperfunction
0.623 0.377 0.000
E27.0 Other adrenocortical overactivity
0.623 0.377 0.000
N03.5 Diffuse mesangiocapillary glomerulonephritis
0.623 0.377 0.000
D63.8 Anaemia in other chronic diseases classified elsewhere
0.622 0.378 0.000
D51.2 Transcobalamin II deficiency
0.621 0.378 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.621 0.378 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.620 0.380 0.000
Q61.8 Other cystic kidney diseases
0.619 0.381 0.000
Q61.4 Renal dysplasia
0.619 0.381 0.000
Q61.1 Polycystic kidney, infantile type
0.619 0.381 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.613 0.382 0.005
M61 Calcification and ossification of muscle
0.613 0.382 0.005
M33.9 Dermatopolymyositis, unspecified
0.615 0.382 0.004
M33.0 Juvenile dermatomyositis
0.615 0.382 0.004
Q63.8 Other specified congenital malformations of kidney
0.615 0.385 0.000
D63.0 Anaemia in neoplastic disease
0.615 0.385 0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified
0.612 0.385 0.002
E24.9 Cushing's syndrome, unspecified
0.612 0.388 0.000
E22.1 Hyperprolactinaemia
0.612 0.388 0.000
Q61.0 Congenital single renal cyst
0.612 0.388 0.000
Q38.1 Ankyloglossia
0.612 0.388 0.000
M24.9 Joint derangement, unspecified
0.610 0.390 0.000
E40-E46 Malnutrition
0.610 0.390 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.610 0.390 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.609 0.391 0.000
N03.7 Diffuse crescentic glomerulonephritis
0.607 0.392 0.000
N03.6 Dense deposit disease
0.607 0.392 0.000
N03.4 Diffuse endocapillary proliferative glomerulonephritis
0.607 0.392 0.000
N03.3 Diffuse mesangial proliferative glomerulonephritis
0.607 0.392 0.000
N03.2 Diffuse membranous glomerulonephritis
0.607 0.392 0.000
N03.0 Minor glomerular abnormality
0.607 0.392 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.393 0.607
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.607 0.393 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.606 0.394 0.000
E29.1 Testicular hypofunction
0.605 0.395 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.605 0.395 0.000
M17.5 Other secondary gonarthrosis
0.605 0.395 0.000
E34 Other endocrine disorders
0.605 0.395 0.000
M23.37 Other meniscus derangements-Capsular lig
0.604 0.396 0.000
Q60.6 Potter's syndrome
0.603 0.397 0.000
Q60.5 Renal hypoplasia, unspecified
0.603 0.397 0.000
Q60.4 Renal hypoplasia, bilateral
0.603 0.397 0.000
Q60.3 Renal hypoplasia, unilateral
0.603 0.397 0.000
Q60.1 Renal agenesis, bilateral
0.603 0.397 0.000
Q45 Other congenital malformations of digestive system
0.600 0.400 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.599 0.401 0.000
Q43 Other congenital malformations of intestine
0.598 0.402 0.000
Q27 Other congenital malformations of peripheral vascular system
0.598 0.402 0.000
Q85 Phakomatoses, not elsewhere classified
0.596 0.404 0.000
Q40 Other congenital malformations of upper alimentary tract
0.596 0.404 0.000
E65-E68 Obesity and other hyperalimentation
0.596 0.404 0.000
E10.8 With unspecified complications
0.595 0.404 0.000
D83.8 Other common variable immunodeficiencies
0.595 0.405 0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.595 0.405 0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.595 0.405 0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.595 0.405 0.000
Q38.6 Other congenital malformations of mouth
0.595 0.405 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.595 0.405 0.000
M15.1 Heberden's nodes (with arthropathy)
0.594 0.406 0.000
M35.2 Behcet's disease
0.584 0.406 0.010
I79.1 Aortitis in diseases classified elsewhere
0.593 0.407 0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.593 0.407 0.000
Q63.3 Hyperplastic and giant kidney
0.593 0.407 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.591 0.408 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.591 0.408 0.000
Q31 Congenital malformations of larynx
0.591 0.408 0.000
Q56 Indeterminate sex and pseudohermaphroditism
0.591 0.409 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.590 0.409 0.000
I13 Hypertensive heart and renal disease
0.589 0.411 0.000
I15 Secondary hypertension
0.587 0.413 0.000
E11.2 With renal complications
0.586 0.414 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.585 0.415 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.584 0.416 0.000
N03.9 Unspecified
0.582 0.418 0.000
I74.8 Embolism and thrombosis of other arteries
0.580 0.420 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.575 0.420 0.004
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.420 0.579
M15.4 Erosive (osteo)arthrosis
0.579 0.421 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.578 0.422 0.000
M12.3 Palindromic rheumatism
0.000 0.422 0.577
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.577 0.423 0.000
I77.6 Arteritis, unspecified
0.576 0.424 0.000
M23.1 Discoid meniscus (congenital)
0.574 0.425 0.000
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.574 0.426 0.000
E28.9 Ovarian dysfunction, unspecified
0.573 0.427 0.000
E28.8 Other ovarian dysfunction
0.573 0.427 0.000
E28.1 Androgen excess
0.573 0.427 0.000
E28.0 Oestrogen excess
0.573 0.427 0.000
D63.1 Anaemia in other chronic diseases classified elsewhere
0.572 0.428 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.572 0.428 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.571 0.429 0.000
M22.1 Recurrent subluxation of patella
0.570 0.429 0.001
Q55 Other congenital malformations of male genital organs
0.570 0.430 0.000
M11 Other crystal arthropathies
0.001 0.430 0.569
E14.6 With other specified complications
0.568 0.432 0.000
E31.0 Autoimmune polyglandular failure
0.568 0.432 0.000
M62.6 Muscle strain
0.565 0.433 0.002
E11.1 With ketoacidosis
0.566 0.434 0.000
I73 Other peripheral vascular diseases
0.566 0.434 0.000
N02.0 Minor glomerular abnormality
0.565 0.435 0.000
M14.6 Neuropathic arthropathy
0.000 0.436 0.563
Q38.8 Other congenital malformations of pharynx
0.561 0.439 0.000
Q38.5 Congenital malformations of palate, not elsewhere classified
0.561 0.439 0.000
Q38.4 Congenital malformations of salivary glands and ducts
0.561 0.439 0.000
Q38.3 Other congenital malformations of tongue
0.561 0.439 0.000
Q38.2 Macroglossia
0.561 0.439 0.000
Q38.0 Congenital malformations of lips, not elsewhere classified
0.561 0.439 0.000
Q64 Other congenital malformations of urinary system
0.561 0.439 0.000
M60.0 Infective myositis
0.558 0.440 0.002
M24.84 Other specific joint derangements, not elsewhere classified (Hand)
0.560 0.440 0.000
D89.3 Immune reconstitution syndrome
0.560 0.440 0.000
M60.8 Other myositis
0.557 0.441 0.003
M60.1 Interstitial myositis
0.557 0.441 0.003
Q24 Other congenital malformations of heart
0.559 0.441 0.000
M14.8 Arthropathies in other specified diseases classified elsewhere
0.000 0.441 0.559
E13.8 With unspecified complications
0.559 0.441 0.000
E13.7 With multiple complications
0.559 0.441 0.000
E13.6 With other specified complications
0.559 0.441 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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