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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4247374
log Bayes Factor = 8.59285
Chromosome 19   position 7,252,756  (GRCh37) Explore rs4247374 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I10 Essential (primary) hypertension
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.027 0.973
Chapter IX Diseases of the circulatory system
0.000 0.043 0.957
I05-I09 Chronic rheumatic heart diseases
0.000 0.055 0.945
I08 Multiple valve diseases
0.000 0.073 0.927
I20-I25 Ischaemic heart diseases
0.000 0.082 0.918
I20.0 Unstable angina
0.000 0.087 0.913
I20 Angina pectoris
0.000 0.088 0.912
I08.0 Disorders of both mitral and aortic valves
0.000 0.110 0.890
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.133 0.867
I22 Subsequent myocardial infarction
0.000 0.133 0.867
I35 Nonrheumatic aortic valve disorders
0.000 0.148 0.852
I30-I52 Other forms of heart disease
0.000 0.151 0.849
I35.0 Aortic (valve) stenosis
0.000 0.153 0.847
I31 Other diseases of pericardium
0.000 0.165 0.835
I05 Rheumatic mitral valve diseases
0.000 0.167 0.833
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.180 0.820
I08.8 Other multiple valve diseases
0.000 0.188 0.812
I31.3 Pericardial effusion (noninflammatory)
0.000 0.192 0.808
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.202 0.798
I11 Hypertensive heart disease
0.000 0.203 0.797
I05.9 Mitral valve disease, unspecified
0.000 0.212 0.788
I27 Other pulmonary heart diseases
0.000 0.231 0.769
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.239 0.761
I35.1 Aortic (valve) insufficiency
0.000 0.239 0.761
I77 Other disorders of arteries and arterioles
0.000 0.241 0.759
I20.1 Angina pectoris with documented spasm
0.000 0.253 0.746
I31.9 Disease of pericardium, unspecified
0.000 0.256 0.744
I27.0 Primary pulmonary hypertension
0.000 0.257 0.743
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.266 0.734
I07 Rheumatic tricuspid valve diseases
0.000 0.280 0.720
I30 Acute pericarditis
0.000 0.286 0.714
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.290 0.710
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.292 0.708
I13 Hypertensive heart and renal disease
0.000 0.302 0.698
I71 Aortic aneurysm and dissection
0.000 0.304 0.696
I00-I02 Acute rheumatic fever
0.000 0.313 0.686
I22.8 Subsequent myocardial infarction of other sites
0.000 0.316 0.684
I74 Arterial embolism and thrombosis
0.000 0.322 0.678
I72 Other aneurysm
0.000 0.329 0.671
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.329 0.671
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.330 0.670
I08.9 Multiple valve disease, unspecified
0.000 0.336 0.664
I09 Other rheumatic heart diseases
0.000 0.344 0.655
I46 Cardiac arrest
0.000 0.346 0.654
I23 Certain current complications following acute myocardial infarction
0.000 0.346 0.654
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.350 0.650
I71.0 Dissection of aorta [any part]
0.000 0.353 0.647
I77.8 Other specified disorders of arteries and arterioles
0.000 0.357 0.643
I45 Other conduction disorders
0.000 0.361 0.639
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.362 0.638
I15 Secondary hypertension
0.000 0.363 0.636
I05.1 Rheumatic mitral insufficiency
0.000 0.367 0.633
I36 Nonrheumatic tricuspid valve disorders
0.000 0.374 0.626
I33 Acute and subacute endocarditis
0.000 0.374 0.626
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.389 0.611
I77.1 Stricture of artery
0.000 0.390 0.610
I06 Rheumatic aortic valve diseases
0.000 0.390 0.610
I52 Other heart disorders in diseases classified elsewhere
0.000 0.391 0.609
I48 Atrial fibrillation and flutter
0.000 0.391 0.609
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.391 0.609
I41 Myocarditis in diseases classified elsewhere
0.000 0.391 0.609
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.391 0.609
I32 Pericarditis in diseases classified elsewhere
0.000 0.391 0.609
I30.1 Infective pericarditis
0.000 0.395 0.605
I27.8 Other specified pulmonary heart diseases
0.000 0.396 0.604
I70 Atherosclerosis
0.000 0.397 0.603
I72.3 Aneurysm of iliac artery
0.000 0.399 0.601
I77.6 Arteritis, unspecified
0.000 0.400 0.600
I31.8 Other specified diseases of pericardium
0.000 0.401 0.599
I31.2 Haemopericardium, not elsewhere classified
0.000 0.401 0.599
I31.1 Chronic constrictive pericarditis
0.000 0.401 0.599
I31.0 Chronic adhesive pericarditis
0.000 0.401 0.599
I05.8 Other mitral valve diseases
0.000 0.402 0.597
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.405 0.595
I37 Pulmonary valve disorders
0.000 0.405 0.595
I45.6 Preexcitation syndrome
0.000 0.408 0.592
I27.9 Pulmonary heart disease, unspecified
0.000 0.409 0.591
I28 Other diseases of pulmonary vessels
0.000 0.412 0.588
I35.8 Other aortic valve disorders
0.000 0.416 0.584
I46.9 Cardiac arrest, unspecified
0.000 0.426 0.574
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.427 0.573
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.433 0.567
I40 Acute myocarditis
0.000 0.439 0.561
I12 Hypertensive renal disease
0.000 0.441 0.559
I07.1 Tricuspid insufficiency
0.000 0.442 0.558
I72.0 Aneurysm of carotid artery
0.000 0.445 0.554
I27.1 Kyphoscoliotic heart disease
0.000 0.448 0.552
I77.2 Rupture of artery
0.000 0.454 0.546
I77.0 Arteriovenous fistula, acquired
0.000 0.454 0.546
I77.5 Necrosis of artery
0.000 0.456 0.544
I77.4 Coeliac artery compression syndrome
0.000 0.456 0.544
I77.3 Arterial fibromuscular dysplasia
0.000 0.456 0.544
I35.9 Aortic valve disorder, unspecified
0.000 0.459 0.541
I30.9 Acute pericarditis, unspecified
0.000 0.464 0.536
I45.5 Other specified heart block
0.000 0.468 0.532
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.468 0.532
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.474 0.526
I79.1 Aortitis in diseases classified elsewhere
0.000 0.474 0.526
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.474 0.526
I07.9 Tricuspid valve disease, unspecified
0.000 0.484 0.516
I07.8 Other tricuspid valve diseases
0.000 0.484 0.516
I07.2 Tricuspid stenosis with insufficiency
0.000 0.484 0.516
I07.0 Tricuspid stenosis
0.000 0.484 0.516
I30.8 Other forms of acute pericarditis
0.000 0.488 0.512
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.488 0.512
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.499 0.500
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.499 0.500
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.499 0.500
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.499 0.500
I45.4 Nonspecific intraventricular block
0.000 0.501 0.499
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.501 0.499
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.501 0.499
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.501 0.499
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.501 0.499
I45.3 Trifascicular block
0.000 0.501 0.498
I73 Other peripheral vascular diseases
0.000 0.502 0.498
I05.2 Mitral stenosis with insufficiency
0.000 0.504 0.495
I02 Rheumatic chorea
0.000 0.508 0.492
I01 Rheumatic fever with heart involvement
0.000 0.508 0.492
I00 Rheumatic fever without mention of heart involvement
0.000 0.508 0.492
I05.0 Mitral stenosis
0.000 0.511 0.488
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.514 0.486
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.514 0.486
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.514 0.486
I72.9 Aneurysm of unspecified site
0.000 0.515 0.485
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.519 0.481
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.519 0.481
I72.2 Aneurysm of renal artery
0.000 0.519 0.481
I72.1 Aneurysm of artery of upper extremity
0.000 0.519 0.481
I78 Diseases of capillaries
0.000 0.519 0.481
I74.8 Embolism and thrombosis of other arteries
0.000 0.525 0.475
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.529 0.471
I09.8 Other specified rheumatic heart diseases
0.000 0.530 0.470
I09.2 Chronic rheumatic pericarditis
0.000 0.530 0.470
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.530 0.470
I09.0 Rheumatic myocarditis
0.000 0.530 0.470
I46.1 Sudden cardiac death, so described
0.000 0.531 0.469
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.531 0.469
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.531 0.469
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.531 0.469
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.531 0.469
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.531 0.469
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.531 0.469
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.531 0.469
I33.0 Acute and subacute infective endocarditis
0.000 0.534 0.465
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.534 0.465
I23.8 Other current complications following acute myocardial infarction
0.000 0.535 0.464
I74.5 Embolism and thrombosis of iliac artery
0.000 0.537 0.462
I45.0 Right fascicular block
0.000 0.542 0.458
I15.9 Seconday hypertension, unspecified
0.000 0.543 0.456
I15.8 Other secondary hypertension
0.000 0.543 0.456
I15.2 Hypertension secondary to endocrine disorders
0.000 0.543 0.456
I15.0 Renovascular hypertension
0.000 0.543 0.456
I20.8 Other forms of angina pectoris
0.000 0.544 0.456
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.548 0.451
I34 Nonrheumatic mitral valve disorders
0.000 0.549 0.451
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.551 0.449
I33.9 Acute endocarditis, unspecified
0.000 0.551 0.449
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.551 0.449
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.551 0.449
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.551 0.449
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.551 0.449
I09.9 Rheumatic heart disease, unspecified
0.000 0.552 0.448
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.563 0.437
I06.8 Other rheumatic aortic valve diseases
0.000 0.563 0.437
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.563 0.437
I06.1 Rheumatic aortic insufficiency
0.000 0.563 0.437
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.563 0.437
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.563 0.437
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.563 0.437
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.563 0.437
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.563 0.437
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.563 0.437
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.563 0.437
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.563 0.437
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.563 0.437
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.563 0.437
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.563 0.437
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.563 0.437
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.563 0.437
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.563 0.437
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.563 0.437
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.563 0.437
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.563 0.437
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.563 0.437
I48.4 Atypical atrial flutter
0.000 0.563 0.437
I48.3 Typical atrial flutter
0.000 0.563 0.437
I48.2 Chronic atrial fibrillation
0.000 0.563 0.437
I48.1 Persistent atrial fibrillation
0.000 0.563 0.437
I48.0 Paroxysmal atrial fibrillation
0.000 0.563 0.437
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.563 0.437
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.563 0.437
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.563 0.437
I70.9 Generalised and unspecified atherosclerosis
0.000 0.567 0.432
I70.8 Atherosclerosis of other arteries
0.000 0.567 0.432
I37.9 Pulmonary valve disorder, unspecified
0.000 0.573 0.426
I37.8 Other pulmonary valve disorders
0.000 0.573 0.426
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.573 0.426
I37.0 Pulmonary valve stenosis
0.000 0.573 0.426
I70.1 Atherosclerosis of renal artery
0.000 0.576 0.424
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.578 0.421
I28.1 Aneurysm of pulmonary artery
0.000 0.578 0.421
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.578 0.421
I28.8 Other specified diseases of pulmonary vessels
0.000 0.578 0.421
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.579 0.421
I45.9 Conduction disorder, unspecified
0.000 0.583 0.417
I37.1 Pulmonary valve insufficiency
0.000 0.588 0.412
I24 Other acute ischaemic heart diseases
0.000 0.591 0.408
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.408 0.592 0.000
G40 Epilepsy
0.407 0.593 0.000
G40.9 Epilepsy, unspecified
0.404 0.596 0.000
I70.0 Atherosclerosis of aorta
0.000 0.596 0.403
I40.8 Other acute myocarditis
0.000 0.598 0.402
I40.1 Isolated myocarditis
0.000 0.598 0.402
I40.0 Infective myocarditis
0.000 0.598 0.402
I15.1 Hypertension secondary to other renal disorders
0.000 0.605 0.395
I72.8 Aneurysm of other specified arteries
0.000 0.616 0.383
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.621 0.379
I06.0 Rheumatic aortic stenosis
0.000 0.631 0.369
I73.8 Other specified peripheral vascular diseases
0.000 0.634 0.366
I12.0 Hypertensive renal disease with renal failure
0.000 0.634 0.366
I26 Pulmonary embolism
0.000 0.635 0.365
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.637 0.363
I45.2 Bifascicular block
0.000 0.638 0.362
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.643 0.357
G40.8 Other epilepsy
0.354 0.646 0.000
I40.9 Acute myocarditis, unspecified
0.000 0.646 0.354
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.647 0.353
I01.8 Other acute rheumatic heart disease
0.000 0.647 0.353
I01.2 Acute rheumatic myocarditis
0.000 0.647 0.353
I01.1 Acute rheumatic endocarditis
0.000 0.647 0.353
I01.0 Acute rheumatic pericarditis
0.000 0.647 0.353
I02.9 Rheumatic chorea without heart involvement
0.000 0.647 0.353
I02.0 Rheumatic chorea with heart involvement
0.000 0.647 0.353
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.647 0.352
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.000 0.651 0.349
I78.9 Disease of capillaries, unspecified
0.000 0.655 0.345
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.657 0.343
I44 Atrioventricular and left bundle-branch block
0.000 0.660 0.340
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
0.337 0.663 0.000
I45.8 Other specified conduction disorders
0.000 0.664 0.335
I46.0 Cardiac arrest with successful resuscitation
0.000 0.668 0.332
I73.9 Peripheral vascular disease, unspecified
0.000 0.669 0.331
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.675 0.325
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.676 0.324
G40.5 Special epileptic syndromes
0.323 0.677 0.000
I12.9 Hypertensive renal disease without renal failure
0.000 0.685 0.314
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.690 0.310
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.690 0.310
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.690 0.310
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.690 0.310
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.309 0.691 0.000
I78.8 Other diseases of capillaries
0.000 0.694 0.306
G40.7 Petit mal, unspecified, without grand mal seizures
0.304 0.696 0.000
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.696 0.304
I50 Heart failure
0.000 0.696 0.304
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.696 0.304
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.699 0.301
I27.2 Other secondary pulmonary hypertension
0.000 0.700 0.300
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.705 0.295
I44.6 Other and unspecified fascicular block
0.000 0.705 0.295
I24.1 Dressler's syndrome
0.000 0.707 0.293
G40.4 Other generalised epilepsy and epileptic syndromes
0.292 0.708 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.291 0.709 0.000
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.710 0.289
I44.2 Atrioventricular block, complete
0.000 0.721 0.279
I51 Complications and ill-defined descriptions of heart disease
0.000 0.726 0.274
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.266 0.734 0.000
I34.0 Mitral (valve) insufficiency
0.000 0.734 0.266
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.738 0.262
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.739 0.260
I47 Paroxysmal tachycardia
0.000 0.740 0.260
I73.0 Raynaud's syndrome
0.000 0.741 0.259
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.742 0.258
I72.4 Aneurysm of artery of lower extremity
0.001 0.743 0.256
I44.5 Left posterior fascicular block
0.000 0.756 0.244
I99 Other and unspecified disorders of circulatory system
0.000 0.756 0.244
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.757 0.243
I51.4 Myocarditis, unspecified
0.000 0.759 0.241
I44.1 Atrioventricular block, second degree
0.000 0.760 0.240
I20.9 Angina pectoris, unspecified
0.000 0.763 0.237
I78.1 Naevus, nonneoplastic
0.000 0.769 0.231
I44.3 Other and unspecified atrioventricular block
0.000 0.778 0.222
I44.4 Left anterior fascicular block
0.000 0.778 0.222
I24.8 Other forms of acute ischaemic heart disease
0.000 0.779 0.221
I50.0 Congestive heart failure
0.000 0.780 0.220
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.782 0.217
I47.0 Reentry ventricular arrhythmia
0.000 0.790 0.210
I95 Hypotension
0.000 0.793 0.207
I34.1 Mitral (valve) prolapse
0.000 0.798 0.202
I97.1 Other functional disturbances following cardiac surgery
0.000 0.803 0.197
I51.5 Myocardial degeneration
0.000 0.803 0.197
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.803 0.197
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.804 0.196
I51.0 Cardiac septal defect, acquired
0.000 0.812 0.188
I95.1 Orthostatic hypotension
0.000 0.821 0.179
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.822 0.178
I51.6 Cardiovascular disease, unspecified
0.000 0.825 0.175
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.825 0.174
I97.0 Postcardiotomy syndrome
0.000 0.825 0.174
I51.9 Heart disease, unspecified
0.000 0.833 0.167
I50.1 Left ventricular failure
0.000 0.833 0.167
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.834 0.166
I95.8 Other hypotension
0.000 0.836 0.164
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.844 0.156
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.844 0.156
I98.0 Cardiovascular syphilis
0.000 0.844 0.156
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.848 0.151
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.853 0.147
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.860 0.140
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.861 0.139
I95.0 Idiopathic hypotension
0.000 0.864 0.135
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.874 0.126
I95.2 Hypotension due to drugs
0.000 0.874 0.126
I45.1 Other and unspecified right bundle-branch block
0.000 0.884 0.116
I51.8 Other ill-defined heart diseases
0.000 0.892 0.108
I44.0 Atrioventricular block, first degree
0.000 0.899 0.101
I38 Endocarditis, valve unspecified
0.005 0.904 0.091
I51.7 Cardiomegaly
0.000 0.906 0.094
I47.1 Supraventricular tachycardia
0.000 0.912 0.088
I47.2 Ventricular tachycardia
0.000 0.921 0.079
I21 Acute myocardial infarction
0.000 0.934 0.066
I42 Cardiomyopathy
0.000 0.936 0.063
Q21.1 Atrial septal defect
0.056 0.944 0.000
Q21 Congenital malformations of cardiac septa
0.056 0.944 0.000
I50.9 Heart failure, unspecified
0.000 0.947 0.053
Q20-Q28 Congenital malformations of the circulatory system
0.053 0.947 0.000
Q21.0 Ventricular septal defect
0.052 0.948 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.051 0.949 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.050 0.950 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.952 0.048
Q23 Congenital malformations of aortic and mitral valves
0.047 0.952 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.953 0.047
T50.9 Other and unspecified drugs, medicaments and biological substances
0.047 0.953 0.000
I42.5 Other restrictive cardiomyopathy
0.001 0.954 0.046
I42.4 Endocardial fibroelastosis
0.001 0.954 0.046
I42.3 Endomyocardial (eosinophilic) disease
0.001 0.954 0.046
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.046 0.954 0.000
I42.6 Alcoholic cardiomyopathy
0.000 0.955 0.044
T50.4 Drugs affecting uric acid metabolism
0.044 0.955 0.000
Q24 Other congenital malformations of heart
0.044 0.956 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.044 0.956 0.000
Q23.1 Congenital insufficiency of aortic valve
0.044 0.956 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.044 0.956 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.001 0.958 0.042
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.958 0.042
T46 Poisoning by agents primarily affecting the cardiovascular system
0.042 0.958 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.042 0.958 0.000
T39.1 4-Aminophenol derivatives
0.042 0.958 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.041 0.959 0.000
T36 Poisoning by systemic antibiotics
0.041 0.959 0.000
I42.2 Other hypertrophic cardiomyopathy
0.000 0.959 0.040
Q21.9 Congenital malformation of cardiac septum, unspecified
0.041 0.959 0.000
Q21.8 Other congenital malformations of cardiac septa
0.041 0.959 0.000
Q21.4 Aortopulmonary septal defect
0.041 0.959 0.000
Q21.3 Tetralogy of Fallot
0.041 0.959 0.000
Q21.2 Atrioventricular septal defect
0.041 0.959 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.041 0.959 0.000
Q28 Other congenital malformations of circulatory system
0.040 0.960 0.000
Q25 Congenital malformations of great arteries
0.040 0.960 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.960 0.040
T43.0 Tricyclic and tetracyclic antidepressants
0.039 0.960 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.039 0.961 0.000
Q50-Q56 Congenital malformations of genital organs
0.039 0.961 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.039 0.961 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.038 0.962 0.000
T42.4 Benzodiazepines
0.038 0.962 0.000
Q26 Congenital malformations of great veins
0.038 0.962 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.038 0.962 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.038 0.962 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.038 0.962 0.000
T42.0 Hydantoin derivatives
0.038 0.962 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.038 0.962 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.037 0.963 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.037 0.963 0.000
Q66 Congenital deformities of feet
0.037 0.963 0.000
Q24.9 Congenital malformation of the heart, unspecified
0.037 0.963 0.000
I21.4 Acute subendocardial myocardial infarction
0.000 0.963 0.037
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.036 0.964 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.036 0.964 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.036 0.964 0.000
Q51 Congenital malformations of uterus and cervix
0.036 0.964 0.000
T50.8 Diagnostic agents
0.036 0.964 0.000
T50.7 Analeptics and opioid receptor antagonists
0.036 0.964 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.036 0.964 0.000
T50.5 Appetite depressants
0.036 0.964 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.036 0.964 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.036 0.964 0.000
T50.1 Loop [high-ceiling] diuretics
0.036 0.964 0.000
T50.0 Mineralocorticoids and their antagonists
0.036 0.964 0.000
Q24.5 Malformation of coronary vessels
0.036 0.964 0.000
T45.0 Antiallergic and antiemetic drugs
0.035 0.965 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.035 0.965 0.000
T42.1 Iminostilbenes
0.035 0.965 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.035 0.965 0.000
Q23.9 Congenital malformation of aortic and mitral valves, unspecified
0.034 0.966 0.000
Q23.8 Other congenital malformations of aortic and mitral valves
0.034 0.966 0.000
Q23.4 Hypoplastic left heart syndrome
0.034 0.966 0.000
Q23.3 Congenital mitral insufficiency
0.034 0.966 0.000
Q23.2 Congenital mitral stenosis
0.034 0.966 0.000
T36.0 Penicillins
0.034 0.966 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.001 0.966 0.034
Q23.0 Congenital stenosis of aortic valve
0.034 0.966 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.034 0.966 0.000
T46.1 Calcium-channel blockers
0.034 0.966 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.033 0.966 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.033 0.966 0.000
Q51.3 Bicornate uterus
0.033 0.967 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.967 0.033
T42.5 Mixed antiepileptics, not elsewhere classified
0.033 0.967 0.000
T42.3 Barbiturates
0.033 0.967 0.000
T42.2 Succinimides and oxazolidinediones
0.033 0.967 0.000
Q50.4 Embryonic cyst of Fallopian tube
0.033 0.967 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.033 0.967 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.033 0.967 0.000
Q66.8 Other congenital deformities of feet
0.033 0.967 0.000
Q27 Other congenital malformations of peripheral vascular system
0.032 0.967 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.032 0.968 0.000
Q66.7 Pes cavus
0.032 0.968 0.000
Q24.6 Congenital heart block
0.032 0.968 0.000
Q24.4 Congenital subaortic stenosis
0.032 0.968 0.000
Q24.3 Pulmonary infundibular stenosis
0.032 0.968 0.000
Q24.2 Cor triatriatum
0.032 0.968 0.000
Q24.1 Levocardia
0.032 0.968 0.000
Q24.0 Dextrocardia
0.032 0.968 0.000
I42.8 Other cardiomyopathies
0.001 0.968 0.031
T39.4 Antirheumatics, not elsewhere classified
0.032 0.968 0.000
T39.2 Pyrazolone derivatives
0.032 0.968 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.032 0.968 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.032 0.968 0.000
T47.7 Emetics
0.032 0.968 0.000
T47.6 Antidiarrhoeal drugs
0.032 0.968 0.000
T47.5 Digestants
0.032 0.968 0.000
T47.4 Other laxatives
0.032 0.968 0.000
T47.3 Saline and osmotic laxatives
0.032 0.968 0.000
T47.2 Stimulant laxatives
0.032 0.968 0.000
T47.0 Histamine H(2)-receptor antagonists
0.032 0.968 0.000
Q28.2 Arteriovenous malformation of cerebral vessels
0.031 0.969 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.031 0.969 0.000
Q24.8 Other specified congenital malformations of heart
0.031 0.969 0.000
Q66.2 Metatarsus varus
0.031 0.969 0.000
Q25.1 Coarctation of aorta
0.030 0.970 0.000
T43.2 Other and unspecified antidepressants
0.030 0.970 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.030 0.970 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.030 0.970 0.000
T46.7 Peripheral vasodilators
0.030 0.970 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.030 0.970 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.030 0.970 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.030 0.970 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.030 0.970 0.000
T45.8 Other primarily systemic and haematological agents
0.030 0.970 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.030 0.970 0.000
T45.6 Fibrinolysis-affecting drugs
0.030 0.970 0.000
T45.4 Iron and its compounds
0.030 0.970 0.000
T45.3 Enzymes, not elsewhere classified
0.030 0.970 0.000
T45.2 Vitamins, not elsewhere classified
0.030 0.970 0.000
T43.9 Psychotropic drug, unspecified
0.030 0.970 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.030 0.970 0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.030 0.970 0.000
T38.1 Thyroid hormones and substitutes
0.030 0.970 0.000
T36.9 Systemic antibiotic, unspecified
0.029 0.970 0.000
T36.8 Other systemic antibiotics
0.029 0.970 0.000
T36.7 Antifungal antibiotics, systemically used
0.029 0.970 0.000
T36.6 Rifamycins
0.029 0.970 0.000
T36.5 Aminoglycosides
0.029 0.970 0.000
T36.4 Tetracyclines
0.029 0.970 0.000
T36.3 Macrolides
0.029 0.970 0.000
T36.2 Chloramphenicol group
0.029 0.970 0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.029 0.970 0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.029 0.971 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.029 0.971 0.000
Q35-Q37 Cleft lip and cleft palate
0.029 0.971 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.029 0.971 0.000
Q51.2 Other doubling of uterus
0.029 0.971 0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.029 0.971 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.029 0.971 0.000
Q28.9 Congenital malformation of circulatory system, unspecified
0.029 0.971 0.000
Q28.8 Other specified congenital malformations of circulatory system
0.029 0.971 0.000
Q28.3 Other malformations of cerebral vessels
0.029 0.971 0.000
Q28.1 Other malformations of precerebral vessels
0.029 0.971 0.000
Q28.0 Arteriovenous malformation of precerebral vessels
0.029 0.971 0.000
Q25.9 Congenital malformation of great arteries, unspecified
0.029 0.971 0.000
Q25.8 Other congenital malformations of great arteries
0.029 0.971 0.000
Q25.7 Other congenital malformations of pulmonary artery
0.029 0.971 0.000
Q25.6 Stenosis of pulmonary artery
0.029 0.971 0.000
Q25.5 Atresia of pulmonary artery
0.029 0.971 0.000
Q25.4 Other congenital malformations of aorta
0.029 0.971 0.000
Q25.3 Stenosis of aorta
0.029 0.971 0.000
Q25.2 Atresia of aorta
0.029 0.971 0.000
Q25.0 Patent ductus arteriosus
0.029 0.971 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.029 0.971 0.000
Q74 Other congenital malformations of limb(s)
0.028 0.971 0.000
Q56 Indeterminate sex and pseudohermaphroditism
0.028 0.972 0.000
Q52 Other congenital malformations of female genitalia
0.028 0.972 0.000
T38.9 Other and unspecified hormone antagonists
0.028 0.972 0.000
T38.8 Other and unspecified hormones and their synthetic substitutes
0.028 0.972 0.000
T38.7 Androgens and anabolic congeners
0.028 0.972 0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.028 0.972 0.000
T38.5 Other oestrogens and progestogens
0.028 0.972 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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