TreeWAS – Variant ID: rs4304868

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
C15.5 Lower third of oesophagus	0.073	0.927	0.000
C15 Malignant neoplasm of oesophagus	0.073	0.927	0.000
C15.9 Oesophagus, unspecified	0.069	0.931	0.000
C15.3 Upper third of oesophagus	0.064	0.935	0.000
C15.0 Cervical part of oesophagus	0.060	0.940	0.000
C15.4 Middle third of oesophagus	0.058	0.942	0.000
C15.8 Overlapping lesion of oesophagus	0.052	0.948	0.000
C15.2 Abdominal part of oesophagus	0.052	0.948	0.000
C15.1 Thoracic part of oesophagus	0.052	0.948	0.000
C15-C26 Malignant neoplasms of digestive organs	0.032	0.968	0.000
C19 Malignant neoplasm of rectosigmoid junction	0.032	0.968	0.000
C16 Malignant neoplasm of stomach	0.029	0.971	0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.029	0.971	0.000
C16.0 Cardia	0.029	0.971	0.000
C22.0 Liver cell carcinoma	0.028	0.972	0.000
C21 Malignant neoplasm of anus and anal canal	0.024	0.976	0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.023	0.977	0.000
C21.8 Overlapping lesion of rectum, anus and anal canal	0.022	0.978	0.000
C16.4 Pylorus	0.021	0.978	0.000
C16.3 Pyloric antrum	0.021	0.978	0.000
C22.9 Liver, unspecified	0.021	0.979	0.000
C16.8 Overlapping lesion of stomach	0.021	0.979	0.000
C16.1 Fundus of stomach	0.021	0.979	0.000
C22.7 Other specified carcinomas of liver	0.021	0.979	0.000
C22.4 Other sarcomas of liver	0.021	0.979	0.000
C22.3 Angiosarcoma of liver	0.021	0.979	0.000
C22.2 Hepatoblastoma	0.021	0.979	0.000
C16.9 Stomach, unspecified	0.021	0.979	0.000
C23 Malignant neoplasm of gallbladder	0.020	0.980	0.000
C16.6 Greater curvature of stomach, unspecified	0.019	0.980	0.000
C17 Malignant neoplasm of small intestine	0.019	0.981	0.000
C16.5 Lesser curvature of stomach, unspecified	0.019	0.981	0.000
C16.2 Body of stomach	0.019	0.981	0.000
D86 Sarcoidosis	0.019	0.981	0.000
D86.0 Sarcoidosis of lung	0.018	0.982	0.000
D86.8 Sarcoidosis of other and combined sites	0.018	0.982	0.000
C22.1 Intrahepatic bile duct carcinoma	0.018	0.982	0.000
C24.1 Ampulla of Vater	0.017	0.983	0.000
C25 Malignant neoplasm of pancreas	0.017	0.983	0.000
C21.2 Cloacogenic zone	0.017	0.983	0.000
C24.8 Overlapping lesion of biliary tract	0.016	0.983	0.000
C26 Malignant neoplasm of other and ill-defined digestive organs	0.016	0.983	0.000
Z30.5 Surveillance of (intra-uterine) contraceptive device	0.000	0.983	0.017
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.016	0.984	0.000
C24.9 Biliary tract, unspecified	0.016	0.984	0.000
D86.9 Sarcoidosis, unspecified	0.016	0.984	0.000
C24.0 Extrahepatic bile duct	0.015	0.984	0.000
C21.0 Anus, unspecified	0.014	0.986	0.000
C17.8 Overlapping lesion of small intestine	0.014	0.986	0.000
C17.3 Meckel's diverticulum	0.014	0.986	0.000
C17.1 Jejunum	0.014	0.986	0.000
C17.9 Small intestine, unspecified	0.014	0.986	0.000
D86.3 Sarcoidosis of skin	0.014	0.986	0.000
C25.7 Other parts of pancreas	0.013	0.987	0.000
C17.2 Ileum	0.013	0.987	0.000
D86.1 Sarcoidosis of lymph nodes	0.013	0.987	0.000
C25.8 Overlapping lesion of pancreas	0.013	0.987	0.000
C25.4 Endocrine pancreas	0.013	0.987	0.000
C25.3 Pancreatic duct	0.013	0.987	0.000
D75.2 Essential thrombocytosis	0.012	0.988	0.000
C25.0 Head of pancreas	0.012	0.988	0.000
C25.2 Tail of pancreas	0.012	0.988	0.000
C26.8 Overlapping lesion of digestive system	0.012	0.988	0.000
C26.1 Spleen	0.012	0.988	0.000
C17.0 Duodenum	0.012	0.988	0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk	0.000	0.988	0.012
D80-D89 Certain disorders involving the immune mechanism	0.012	0.988	0.000
D75 Other diseases of blood and blood-forming organs	0.012	0.988	0.000
C26.9 Ill-defined sites within the digestive system	0.011	0.989	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.011	0.989	0.000
C25.9 Pancreas, unspecified	0.011	0.989	0.000
D89.2 Hypergammaglobulinaemia, unspecified	0.011	0.989	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.011	0.989	0.000
C21.1 Anal canal	0.010	0.989	0.000
C20 Malignant neoplasm of rectum	0.010	0.990	0.000
D75.8 Other specified diseases of blood and blood-forming organs	0.010	0.990	0.000
D75.1 Secondary polycythaemia	0.010	0.990	0.000
C25.1 Body of pancreas	0.009	0.991	0.000
D75.0 Familial erythrocytosis	0.009	0.991	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.009	0.991	0.000
D82 Immunodeficiency associated with other major defects	0.008	0.991	0.000
D81 Combined immunodeficiencies	0.008	0.991	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.008	0.991	0.000
D83 Common variable immunodeficiency	0.008	0.991	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.008	0.992	0.000
D89.3 Immune reconstitution syndrome	0.008	0.992	0.000
D89.1 Cryoglobulinaemia	0.008	0.992	0.000
D84 Other immunodeficiencies	0.007	0.993	0.000
C26.0 Intestinal tract, part unspecified	0.006	0.993	0.001
C18 Malignant neoplasm of colon	0.007	0.993	0.000
D80 Immunodeficiency with predominantly antibody defects	0.006	0.993	0.000
D81.9 Combined immunodeficiency, unspecified	0.006	0.994	0.000
D81.8 Other combined immunodeficiencies	0.006	0.994	0.000
D81.7 Major histocompatibility complex class II deficiency	0.006	0.994	0.000
D81.6 Major histocompatibility complex class I deficiency	0.006	0.994	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.006	0.994	0.000
D81.4 Nezelof's syndrome	0.006	0.994	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.006	0.994	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.006	0.994	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.006	0.994	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.006	0.994	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.006	0.994	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.006	0.994	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.006	0.994	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.006	0.994	0.000
D82.2 Immunodeficiency with short-limbed stature	0.006	0.994	0.000
D82.1 Di George's syndrome	0.006	0.994	0.000
D82.0 Wiskott-Aldrich syndrome	0.006	0.994	0.000
D83.8 Other common variable immunodeficiencies	0.006	0.994	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.006	0.994	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.006	0.994	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.006	0.994	0.000
C18.5 Splenic flexure	0.006	0.994	0.000
D83.9 Common variable immunodeficiency, unspecified	0.006	0.994	0.000
G25.0 Essential tremor	0.000	0.994	0.006
C18.2 Ascending colon	0.006	0.994	0.000
D84.8 Other specified immunodeficiencies	0.005	0.994	0.000
D84.1 Defects in the complement system	0.005	0.994	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.005	0.994	0.000
C18.6 Descending colon	0.005	0.995	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.005	0.995	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.005	0.995	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.005	0.995	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.005	0.995	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.005	0.995	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.005	0.995	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.005	0.995	0.000
C18.9 Colon, unspecified	0.005	0.995	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.005	0.995	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.005	0.995	0.000
C18.8 Overlapping lesion of colon	0.005	0.995	0.000
D84.9 Immunodeficiency, unspecified	0.004	0.996	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.004	0.996	0.000
H52.1 Myopia	0.004	0.996	0.000
M41.99 Scoliosis, unspecified (Site unspecified)	0.000	0.996	0.004
H74.3 Other acquired abnormalities of ear ossicles	0.000	0.996	0.004
V18.0 Driver injured in nontraffic accident	0.000	0.996	0.004
T43.0 Tricyclic and tetracyclic antidepressants	0.000	0.996	0.004
R94.3 Abnormal results of cardiovascular function studies	0.004	0.996	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.004	0.996	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.003	0.996	0.000
H74.9 Disorder of middle ear and mastoid, unspecified	0.000	0.996	0.004
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.003	0.996	0.000
H74 Other disorders of middle ear and mastoid	0.000	0.996	0.004
M25.76 Osteophyte (Lower leg)	0.000	0.996	0.003
H53.0 Amblyopia ex anopsia	0.003	0.997	0.000
D74 Methaemoglobinaemia	0.003	0.997	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.003	0.997	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.003	0.997	0.000
C18.1 Appendix	0.003	0.997	0.000
C18.4 Transverse colon	0.003	0.997	0.000
A41.5 Septicaemia due to other Gram-negative organisms	0.000	0.997	0.003
R10.2 Pelvic and perineal pain	0.003	0.997	0.000
N90.8 Other specified noninflammatory disorders of vulva and perineum	0.003	0.997	0.000
C50.2 Upper-inner quadrant of breast	0.000	0.997	0.003
H74.1 Adhesive middle ear disease	0.000	0.997	0.003
C18.3 Hepatic flexure	0.003	0.997	0.000
D72 Other disorders of white blood cells	0.003	0.997	0.000
C18.7 Sigmoid colon	0.003	0.997	0.000
D55-D59 Haemolytic anaemias	0.003	0.997	0.000
D76.3 Other histiocytosis syndromes	0.003	0.997	0.000
Z91.5 Personal history of self-harm	0.000	0.997	0.003
M41.9 Scoliosis, unspecified	0.000	0.997	0.003
H74.4 Polyp of middle ear	0.000	0.997	0.003
N90.4 Leukoplakia of vulva	0.003	0.997	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.003	0.997	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.003	0.997	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.003	0.997	0.000
H74.2 Discontinuity and dislocation of ear ossicles	0.000	0.997	0.003
M41.96 Scoliosis, unspecified (Lumbar region)	0.000	0.997	0.003
H74.0 Tympanosclerosis	0.000	0.997	0.003
T93.8 Sequelae of other specified injuries of lower limb	0.000	0.997	0.003
D63.0 Anaemia in neoplastic disease	0.003	0.997	0.000
H74.8 Other specified disorders of middle ear and mastoid	0.000	0.997	0.003
N03.9 Unspecified	0.003	0.997	0.000
D74.9 Methaemoglobinaemia, unspecified	0.002	0.997	0.000
D74.8 Other methaemoglobinaemias	0.002	0.997	0.000
D74.0 Congenital methaemoglobinaemia	0.002	0.997	0.000
F23.9 Acute and transient psychotic disorder, unspecified	0.000	0.997	0.003
N31.8 Other neuromuscular dysfunction of bladder	0.003	0.997	0.000
D59 Acquired haemolytic anaemia	0.003	0.997	0.000
D72.8 Other specified disorders of white blood cells	0.003	0.997	0.000
L53.9 Erythematous condition, unspecified	0.000	0.997	0.003
Y83.2 Surgical operation with anastomosis, bypass or graft	0.003	0.997	0.000
D72.9 Disorder of white blood cells, unspecified	0.002	0.998	0.000
D72.0 Genetic anomalies of leukocytes	0.002	0.998	0.000
D60-D64 Aplastic and other anaemias	0.002	0.998	0.000
K14.8 Other diseases of tongue	0.000	0.998	0.002
D57 Sickle-cell disorders	0.002	0.998	0.000
D55 Anaemia due to enzyme disorders	0.002	0.998	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.002	0.998	0.000
D56 Thalassaemia	0.002	0.998	0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)	0.000	0.998	0.002
Z91.6 Personal history of other physical trauma	0.000	0.998	0.002
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)	0.000	0.998	0.002
M41.97 Scoliosis, unspecified (Lumbosacral region)	0.000	0.998	0.002
M41.94 Scoliosis, unspecified (Thoracic region)	0.000	0.998	0.002
M41.93 Scoliosis, unspecified (Cervicothoracic region)	0.000	0.998	0.002
M41.92 Scoliosis, unspecified (Cervical region)	0.000	0.998	0.002
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)	0.000	0.998	0.002
M34.1 CR(E)ST syndrome	0.002	0.998	0.000
M34.9 Systemic sclerosis, unspecified	0.002	0.998	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.002	0.998	0.000
S62.30 Fracture of other metacarpal bone (closed)	0.000	0.998	0.002
D58 Other hereditary haemolytic anaemias	0.002	0.998	0.000
D62 Acute posthaemorrhagic anaemia	0.002	0.998	0.000
V18 Pedal cyclist injured in noncollision transport accident	0.000	0.998	0.002
D48.5 Skin	0.002	0.998	0.000
D59.8 Other acquired haemolytic anaemias	0.002	0.998	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.002	0.998	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.002	0.998	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.002	0.998	0.000
D59.3 Haemolytic-uraemic syndrome	0.002	0.998	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.002	0.998	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.002	0.998	0.000
M34.8 Other forms of systemic sclerosis	0.002	0.998	0.000
M34 Systemic sclerosis	0.002	0.998	0.000
D59.1 Other autoimmune haemolytic anaemias	0.002	0.998	0.000
M34.0 Progressive systemic sclerosis	0.002	0.998	0.000
Z73.9 Problem related to life-management difficulty, unspecified	0.002	0.998	0.000
T93 Sequelae of injuries of lower limb	0.000	0.998	0.002
Z95.4 Presence of other heart-valve replacement	0.000	0.998	0.002
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.002	0.998	0.000
M41.90 Scoliosis, unspecified (Multiple sites in spine)	0.000	0.998	0.002
D55.9 Anaemia due to enzyme disorder, unspecified	0.002	0.998	0.000
D55.8 Other anaemias due to enzyme disorders	0.002	0.998	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.002	0.998	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.002	0.998	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.002	0.998	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.002	0.998	0.000
D57.8 Other sickle-cell disorders	0.002	0.998	0.000
D57.3 Sickle-cell trait	0.002	0.998	0.000
D57.2 Double heterozygous sickling disorders	0.002	0.998	0.000
D57.1 Sickle-cell anaemia without crisis	0.002	0.998	0.000
D57.0 Sickle-cell anaemia with crisis	0.002	0.998	0.000
M94.86 Other specified disorders of cartilage (Lower leg)	0.000	0.998	0.002
T93.1 Sequelae of fracture of femur	0.000	0.998	0.002
D73 Diseases of spleen	0.002	0.998	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.002	0.998	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.002	0.998	0.000
M71.26 Synovial cyst of popliteal space [Baker]-Lower Leg	0.002	0.998	0.000
D56.9 Thalassaemia, unspecified	0.002	0.998	0.000
D56.8 Other thalassaemias	0.002	0.998	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.002	0.998	0.000
D56.2 Delta-beta thalassaemia	0.002	0.998	0.000
D56.1 Beta thalassaemia	0.002	0.998	0.000
D56.0 Alpha thalassaemia	0.002	0.998	0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems	0.000	0.998	0.002
T93.2 Sequelae of other fractures of lower limb	0.000	0.998	0.002
D72.1 Eosinophilia	0.002	0.998	0.000
V18.2 Unspecified pedal cyclist injured in nontraffic accident	0.000	0.998	0.002
J86.9 Pyothorax without fistula	0.000	0.998	0.002
D56.3 Thalassaemia trait	0.002	0.998	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.002	0.998	0.000
C49.9 Connective and soft tissue, unspecified	0.002	0.998	0.000
T93.9 Sequelae of unspecified injury of lower limb	0.000	0.998	0.002
Z04.8 Examination and observation for other specified reasons	0.000	0.998	0.002
D67 Hereditary factor IX deficiency	0.002	0.998	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.002	0.998	0.000
D58.2 Other haemoglobinopathies	0.002	0.998	0.000
D58.1 Hereditary elliptocytosis	0.002	0.998	0.000
I08.0 Disorders of both mitral and aortic valves	0.000	0.998	0.002
N76.4 Abscess of vulva	0.002	0.998	0.000
V18.9 Unspecified pedal cyclist injured in traffic accident	0.000	0.998	0.002
V18.4 Driver injured in traffic accident	0.000	0.998	0.002
V18.5 Passenger injured in traffic accident	0.000	0.998	0.002
D58.0 Hereditary spherocytosis	0.002	0.998	0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.000	0.998	0.002
M70.65 Trochanteric bursitis-Pelvic/Thigh	0.002	0.998	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.002	0.998	0.000
V18.3 Person injured while boarding or alighting	0.000	0.998	0.002
N41.9 Inflammatory disease of prostate, unspecified	0.000	0.998	0.002
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb	0.000	0.998	0.002
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.000	0.998	0.002
T93.4 Sequelae of injury of nerve of lower limb	0.000	0.998	0.002
Z91 Personal history of risk-factors, not elsewhere classified	0.000	0.998	0.002
D60.9 Acquired pure red cell aplasia, unspecified	0.002	0.998	0.000
D60.8 Other acquired pure red cell aplasias	0.002	0.998	0.000
D60.1 Transient acquired pure red cell aplasia	0.002	0.998	0.000
D60.0 Chronic acquired pure red cell aplasia	0.002	0.998	0.000
R05 Cough	0.000	0.998	0.002
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.000	0.998	0.002
D21.2 Connective and other soft tissue of lower limb, including hip	0.000	0.998	0.002
D73.9 Disease of spleen, unspecified	0.002	0.998	0.000
D73.4 Cyst of spleen	0.002	0.998	0.000
D73.3 Abscess of spleen	0.002	0.998	0.000
D73.2 Chronic congestive splenomegaly	0.002	0.998	0.000
D73.1 Hypersplenism	0.002	0.998	0.000
N41.0 Acute prostatitis	0.000	0.998	0.002
D61 Other aplastic anaemias	0.001	0.998	0.001
I38 Endocarditis, valve unspecified	0.000	0.998	0.002
Z91.1 Personal history of noncompliance with medical treatment and regimen	0.000	0.998	0.002
G25 Other extrapyramidal and movement disorders	0.000	0.998	0.002
T93.0 Sequelae of open wound of lower limb	0.000	0.998	0.002
V18.1 Passenger injured in nontraffic accident	0.000	0.998	0.001
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)	0.002	0.998	0.000
C18.0 Caecum	0.002	0.998	0.000
F50.0 Anorexia nervosa	0.002	0.998	0.000
V18.49 Pedal cyclist injured in noncollision transport accident; driver injured in traffic accident ; during unspecified activity	0.000	0.998	0.001
V18.99 Pedal cyclist injured in noncollision transport accident; unspecified pedal cyclist injured in traffic accident; during unspecified activity	0.000	0.998	0.001
D58.9 Hereditary haemolytic anaemia, unspecified	0.001	0.998	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.001	0.998	0.000
H53.8 Other visual disturbances	0.002	0.998	0.000
C49.5 Connective and soft tissue of pelvis	0.001	0.998	0.000
Z91.8 Personal history of other specified risk-factors, not elsewhere classified	0.000	0.998	0.001
H72.9 Perforation of tympanic membrane, unspecified	0.000	0.998	0.002
R16.1 Splenomegaly, not elsewhere classified	0.000	0.998	0.002
Z91.7 Personal history of female genital mutilation	0.000	0.998	0.001
Z91.4 Personal history of psychological trauma, not elsewhere classified	0.000	0.998	0.001
Z91.3 Personal history of unhealthy sleep-wake schedule	0.000	0.998	0.001
Z91.2 Personal history of poor personal hygiene	0.000	0.998	0.001
C49.1 Connective and soft tissue of upper limb, including shoulder	0.001	0.998	0.000
D73.8 Other diseases of spleen	0.001	0.998	0.000
F52.2 Failure of genital response	0.002	0.998	0.000
G60.0 Hereditary motor and sensory neuropathy	0.001	0.998	0.000
C49 Malignant neoplasm of other connective and soft tissue	0.002	0.998	0.000
Z30 Contraceptive management	0.000	0.998	0.002
M62.83 Other specified disorders of muscle (Forearm)	0.001	0.998	0.000
M79.79 Fibromyalgia (Site unspecified)	0.002	0.998	0.000
D61.8 Other specified aplastic anaemias	0.001	0.998	0.001
D61.3 Idiopathic aplastic anaemia	0.001	0.998	0.001
D61.2 Aplastic anaemia due to other external agents	0.001	0.998	0.001
D61.1 Drug-induced aplastic anaemia	0.001	0.998	0.001
D73.5 Infarction of spleen	0.001	0.998	0.000
M62.8 Other specified disorders of muscle	0.001	0.998	0.000
N92.4 Excessive bleeding in the premenopausal period	0.002	0.998	0.000
O42.9 Premature rupture of membranes, unspecified	0.000	0.998	0.002
T78.4 Allergy, unspecified	0.000	0.998	0.002
A69.2 Lyme disease	0.001	0.998	0.000
C49.4 Connective and soft tissue of abdomen	0.001	0.998	0.000
N80.8 Other endometriosis	0.001	0.998	0.000
Z04.9 Examination and observation for unspecified reason	0.000	0.998	0.001
D66 Hereditary factor VIII deficiency	0.001	0.998	0.000
N03 Chronic nephritic syndrome	0.001	0.998	0.000
D61.0 Constitutional aplastic anaemia	0.001	0.999	0.000
G25.6 Drug-induced tics and other tics of organic origin	0.000	0.999	0.001
G25.5 Other chorea	0.000	0.999	0.001
G25.4 Drug-induced chorea	0.000	0.999	0.001
G25.2 Other specified forms of tremor	0.000	0.999	0.001
G25.1 Drug-induced tremor	0.000	0.999	0.001
K12.2 Cellulitis and abscess of mouth	0.001	0.999	0.000
K35.9 Acute appendicitis, unspecified	0.000	0.999	0.001
M62.59 Muscle wasting and atrophy, not elsewhere classified (Site unspecified)	0.001	0.999	0.000
G25.9 Extrapyramidal and movement disorder, unspecified	0.000	0.999	0.001
M19.95 Arthrosis, unspecified (Pelvic region and thigh)	0.001	0.999	0.000
C49.0 Connective and soft tissue of head, face and neck	0.001	0.999	0.000
T78.2 Anaphylactic shock, unspecified	0.000	0.999	0.001
Z30.3 Menstrual extraction	0.000	0.999	0.001
M76.66 Achilles tendinitis (Lower leg)	0.001	0.999	0.000
M15.1 Heberden's nodes (with arthropathy)	0.001	0.999	0.000
M62.84 Other specified disorders of muscle (Hand)	0.001	0.999	0.000
I31.9 Disease of pericardium, unspecified	0.001	0.999	0.000
M94.8 Other specified disorders of cartilage	0.000	0.999	0.001
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.000	0.999	0.001
C49.6 Connective and soft tissue of trunk, unspecified	0.001	0.999	0.000
D25.0 Submucous leiomyoma of uterus	0.000	0.999	0.001
N89.9 Noninflammatory disorder of vagina, unspecified	0.001	0.999	0.000
L02 Cutaneous abscess, furuncle and carbuncle	0.000	0.999	0.001
D61.9 Aplastic anaemia, unspecified	0.000	0.999	0.001
G60.8 Other hereditary and idiopathic neuropathies	0.001	0.999	0.000
Z47.8 Other specified orthopaedic follow-up care	0.000	0.999	0.001
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.001	0.999	0.000
C49.8 Overlapping lesion of connective and soft tissue	0.001	0.999	0.000
I07.1 Tricuspid insufficiency	0.000	0.999	0.001
L27.1 Localised skin eruption due to drugs and medicaments	0.001	0.999	0.000
M71.2 Synovial cyst of popliteal space [Baker]	0.001	0.999	0.000
V19.3 Pedal cyclist [any] injured in an unspecified nontraffic accident	0.000	0.999	0.001
Z30.9 Contraceptive management, unspecified	0.000	0.999	0.001
Z30.4 Surveillance of contraceptive drugs	0.000	0.999	0.001
M62.89 Other specified disorders of muscle (Site unspecified)	0.001	0.999	0.000
M62.87 Other specified disorders of muscle (Ankle and foot)	0.001	0.999	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.001	0.999	0.000
N03.8 Other	0.001	0.999	0.000
N03.7 Diffuse crescentic glomerulonephritis	0.001	0.999	0.000
N03.6 Dense deposit disease	0.001	0.999	0.000
N03.5 Diffuse mesangiocapillary glomerulonephritis	0.001	0.999	0.000
N03.4 Diffuse endocapillary proliferative glomerulonephritis	0.001	0.999	0.000
N03.3 Diffuse mesangial proliferative glomerulonephritis	0.001	0.999	0.000
N03.2 Diffuse membranous glomerulonephritis	0.001	0.999	0.000
N03.1 Focal and segmental glomerular lesions	0.001	0.999	0.000
N03.0 Minor glomerular abnormality	0.001	0.999	0.000
Z30.8 Other contraceptive management	0.000	0.999	0.001
M81.90 Osteoporosis, unspecified (Multiple sites)	0.001	0.999	0.000
M94.88 Other specified disorders of cartilage (Other)	0.000	0.999	0.001
B25.9 Cytomegaloviral disease, unspecified	0.000	0.999	0.001
Q50.4 Embryonic cyst of Fallopian tube	0.000	0.999	0.001
M62.81 Other specified disorders of muscle (Shoulder region)	0.001	0.999	0.000
M15.2 Bouchard's nodes (with arthropathy)	0.001	0.999	0.000
N90.1 Moderate vulvar dysplasia	0.001	0.999	0.000
H53 Visual disturbances	0.001	0.999	0.000
M41 Scoliosis	0.000	0.999	0.001
M62.50 Muscle wasting and atrophy, not elsewhere classified (Multiple sites)	0.001	0.999	0.000
M62.86 Other specified disorders of muscle (Lower leg)	0.001	0.999	0.000
M94.87 Other specified disorders of cartilage (Ankle and foot)	0.000	0.999	0.001
M94.85 Other specified disorders of cartilage (Pelvic region and thigh)	0.000	0.999	0.001
M94.84 Other specified disorders of cartilage (Hand)	0.000	0.999	0.001
M94.83 Other specified disorders of cartilage (Forearm)	0.000	0.999	0.001
M94.82 Other specified disorders of cartilage (Upper arm)	0.000	0.999	0.001
M94.81 Other specified disorders of cartilage (Shoulder region)	0.000	0.999	0.001
M94.80 Other specified disorders of cartilage (Multiple sites)	0.000	0.999	0.001
D69.5 Secondary thrombocytopenia	0.001	0.999	0.000
K35.3 Acute appendicitis with localized peritonitis	0.000	0.999	0.001
Z35.0 Supervision of pregnancy with history of infertility	0.001	0.999	0.000
M62.82 Other specified disorders of muscle (Upper arm)	0.001	0.999	0.000
M94.26 Chondromalacia (Lower leg)	0.000	0.999	0.001
B34.9 Viral infection, unspecified	0.000	0.999	0.001
C49.3 Connective and soft tissue of thorax	0.001	0.999	0.000
F01.9 Vascular dementia, unspecified	0.000	0.999	0.001
L27.0 Generalised skin eruption due to drugs and medicaments	0.001	0.999	0.000
D64 Other anaemias	0.001	0.999	0.000
D68.6 Other Thrombophilia	0.001	0.999	0.000
D68.4 Acquired coagulation factor deficiency	0.001	0.999	0.000
N99.8 Other postprocedural disorders of genito-urinary system	0.001	0.999	0.000
N90 Other noninflammatory disorders of vulva and perineum	0.001	0.999	0.000
M62.58 Muscle wasting and atrophy, not elsewhere classified (Other)	0.001	0.999	0.000
M62.57 Muscle wasting and atrophy, not elsewhere classified (Ankle and foot)	0.001	0.999	0.000
M62.56 Muscle wasting and atrophy, not elsewhere classified (Lower leg)	0.001	0.999	0.000
M62.55 Muscle wasting and atrophy, not elsewhere classified (Pelvic region and thigh)	0.001	0.999	0.000
M62.54 Muscle wasting and atrophy, not elsewhere classified (Hand)	0.001	0.999	0.000
M62.53 Muscle wasting and atrophy, not elsewhere classified (Forearm)	0.001	0.999	0.000
M62.52 Muscle wasting and atrophy, not elsewhere classified (Upper arm)	0.001	0.999	0.000
M62.51 Muscle wasting and atrophy, not elsewhere classified (Shoulder region)	0.001	0.999	0.000
M71.29 Synovial cyst of popliteal space [Baker]-Site unspec	0.001	0.999	0.000
M71.28 Synovial cyst of popliteal space [Baker]-Other	0.001	0.999	0.000
M71.27 Synovial cyst of popliteal space [Baker]-Ankle/Foot	0.001	0.999	0.000
M71.25 Synovial cyst of popliteal space [Baker]-Pelvic/Thigh	0.001	0.999	0.000
M71.24 Synovial cyst of popliteal space [Baker]-Hand	0.001	0.999	0.000
M71.23 Synovial cyst of popliteal space [Baker]-Forearm	0.001	0.999	0.000
M71.22 Synovial cyst of popliteal space [Baker]-Upper arm	0.001	0.999	0.000
M71.21 Synovial cyst of popliteal space [Baker]-Shldr region	0.001	0.999	0.000
M71.20 Synovial cyst of popliteal space [Baker]-Mult sites	0.001	0.999	0.000
S82.60 Fracture of lateral malleolus (closed)	0.000	0.999	0.001
D43.0 Brain, supratentorial	0.001	0.999	0.000
G82.2 Paraplegia, unspecified	0.000	0.999	0.001
H52.7 Disorder of refraction, unspecified	0.001	0.999	0.000
H52 Disorders of refraction and accommodation	0.001	0.999	0.000
D64.8 Other specified anaemias	0.001	0.999	0.000
T23.2 Burn of second degree of wrist and hand	0.001	0.999	0.000
Z30.0 General counselling and advice on contraception	0.000	0.999	0.001
D68 Other coagulation defects	0.001	0.999	0.000
F52 Sexual dysfunction, not caused by organic disorder or disease	0.001	0.999	0.000
F50 Eating disorders	0.001	0.999	0.000
F52.0 Lack or loss of sexual desire	0.001	0.999	0.000
H53.6 Night blindness	0.001	0.999	0.000
H53.5 Colour vision deficiencies	0.001	0.999	0.000
H53.3 Other disorders of binocular vision	0.001	0.999	0.000
M41.4 Neuromuscular scoliosis	0.000	0.999	0.001
M41.3 Thoracogenic scoliosis	0.000	0.999	0.001
M41.2 Other idiopathic scoliosis	0.000	0.999	0.001
M41.1 Juvenile idiopathic scoliosis	0.000	0.999	0.001
M41.0 Infantile idiopathic scoliosis	0.000	0.999	0.001
O24.4 Diabetes mellitus arising in pregnancy	0.001	0.999	0.000
Q79.6 Ehlers-Danlos syndrome	0.001	0.999	0.000
T42.4 Benzodiazepines	0.000	0.999	0.001
F23 Acute and transient psychotic disorders	0.000	0.999	0.001
D68.5 Primary Thrombophilia	0.001	0.999	0.000
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites	0.000	0.999	0.001
M70.6 Trochanteric bursitis	0.001	0.999	0.000
B07 Viral warts	0.000	0.999	0.001
D64.4 Congenital dyserythropoietic anaemia	0.001	0.999	0.000
D64.3 Other sideroblastic anaemias	0.001	0.999	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.001	0.999	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.001	0.999	0.000
D64.0 Hereditary sideroblastic anaemia	0.001	0.999	0.000
E53.8 Deficiency of other specified B group vitamins	0.000	0.999	0.001
L02.4 Cutaneous abscess, furuncle and carbuncle of limb	0.000	0.999	0.001
N90.2 Severe vulvar dysplasia, not elsewhere classified	0.001	0.999	0.000
S62.3 Fracture of other metacarpal bone	0.000	0.999	0.001
M62 Other disorders of muscle	0.001	0.999	0.000
S02.60 Fracture of mandible (closed)	0.001	0.999	0.000
D68.1 Hereditary factor XI deficiency	0.001	0.999	0.000
D69.9 Haemorrhagic condition, unspecified	0.001	0.999	0.000
F52.9 Unspecified sexual dysfunction, not caused by organic disorder or disease	0.001	0.999	0.000
F52.8 Other sexual dysfunction, not caused by organic disorder or disease	0.001	0.999	0.000
F52.7 Excessive sexual drive	0.001	0.999	0.000
F52.6 Nonorganic dyspareunia	0.001	0.999	0.000
F52.5 Nonorganic vaginismus	0.001	0.999	0.000
F52.4 Premature ejaculation	0.001	0.999	0.000
F52.3 Orgasmic dysfunction	0.001	0.999	0.000
F52.1 Sexual aversion and lack of sexual enjoyment	0.001	0.999	0.000
H52.6 Other disorders of refraction	0.001	0.999	0.000
H52.5 Disorders of accommodation	0.001	0.999	0.000
H52.4 Presbyopia	0.001	0.999	0.000
Z04.1 Examination and observation following transport accident	0.000	0.999	0.001
J86 Pyothorax	0.000	0.999	0.001
C49.2 Connective and soft tissue of lower limb, including hip	0.001	0.999	0.000
F50.8 Other eating disorders	0.001	0.999	0.000
F50.5 Vomiting associated with other psychological disturbances	0.001	0.999	0.000
F50.4 Overeating associated with other psychological disturbances	0.001	0.999	0.000
F50.3 Atypical bulimia nervosa	0.001	0.999	0.000
F50.1 Atypical anorexia nervosa	0.001	0.999	0.000
M15.8 Other polyarthrosis	0.001	0.999	0.000
M41.5 Other secondary scoliosis	0.000	0.999	0.001
Q74.2 Other congenital malformations of lower limb(s), including pelvic girdle	0.001	0.999	0.000
M41.09 Infantile idiopathic scoliosis (Site unspecified)	0.000	0.999	0.001
M41.08 Infantile idiopathic scoliosis (Sacral and sacrococcygeal region)	0.000	0.999	0.001
M41.07 Infantile idiopathic scoliosis (Lumbosacral region)	0.000	0.999	0.001
M41.06 Infantile idiopathic scoliosis (Lumbar region)	0.000	0.999	0.001
M41.05 Infantile idiopathic scoliosis (Thoracolumbar region)	0.000	0.999	0.001
M41.04 Infantile idiopathic scoliosis (Thoracic region)	0.000	0.999	0.001

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations