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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4348357
log Bayes Factor = 187.91
Chromosome 6   position 32,291,359  (GRCh37) Explore rs4348357 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E03 Other hypothyroidism
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E14.3 With ophthalmic complications
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.001 0.999
E10.4 With neurological complications
0.000 0.001 0.999
E14.9 Without complications
0.000 0.001 0.999
# Top node
0.000 0.001 0.999
L40.5 Arthropathic psoriasis
0.000 0.002 0.998
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.003 0.997
E11.9 Without complications
0.000 0.003 0.997
M07 Psoriatic and enteropathic arthropathies
0.000 0.004 0.996
E11.1 With ketoacidosis
0.000 0.004 0.996
E11.3 With ophthalmic complications
0.000 0.006 0.994
M07.3 Other psoriatic arthropathies
0.000 0.006 0.994
E10.5 With peripheral circulatory complications
0.000 0.008 0.992
J33.0 Polyp of nasal cavity
0.000 0.008 0.992
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.009 0.991
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.009 0.991
J33 Nasal polyp
0.000 0.009 0.991
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.010 0.990
G35-G37 Demyelinating diseases of the central nervous system
0.990 0.010 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.010 0.990
Chapter XI Diseases of the digestive system
0.000 0.011 0.989
K90 Intestinal malabsorption
0.000 0.011 0.989
G37 Other demyelinating diseases of central nervous system
0.988 0.012 0.000
L40-L45 Papulosquamous disorders
0.000 0.013 0.987
K90-K93 Other diseases of the digestive system
0.000 0.013 0.987
D60-D64 Aplastic and other anaemias
0.000 0.015 0.985
G37.9 Demyelinating disease of central nervous system, unspecified
0.985 0.015 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.015 0.985
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.015 0.985
D64.9 Anaemia, unspecified
0.000 0.015 0.985
D64 Other anaemias
0.000 0.016 0.984
E06 Thyroiditis
0.000 0.017 0.983
J33.9 Nasal polyp, unspecified
0.000 0.017 0.983
K70-K77 Diseases of liver
0.000 0.018 0.982
D50-D53 Nutritional anaemias
0.000 0.019 0.981
E10.2 With renal complications
0.000 0.024 0.976
D50 Iron deficiency anaemia
0.000 0.024 0.976
J33.8 Other polyp of sinus
0.000 0.025 0.975
H43-H45 Disorders of vitreous body and globe
0.000 0.025 0.975
K75 Other inflammatory liver diseases
0.000 0.027 0.973
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.027 0.973
E06.3 Autoimmune thyroiditis
0.000 0.027 0.973
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.029 0.971
E10.0 With coma
0.000 0.037 0.963
H43 Disorders of vitreous body
0.000 0.037 0.963
D50.9 Iron deficiency anaemia, unspecified
0.000 0.038 0.962
K75.4 Autoimmune hepatitis
0.000 0.038 0.962
E83 Disorders of mineral metabolism
0.938 0.039 0.024
E11.2 With renal complications
0.000 0.045 0.955
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.052 0.948
L40.0 Psoriasis vulgaris
0.000 0.056 0.944
K74 Fibrosis and cirrhosis of liver
0.000 0.058 0.942
E07 Other disorders of thyroid
0.000 0.058 0.942
D50.8 Other iron deficiency anaemias
0.000 0.060 0.940
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.062 0.938
E70-E90 Metabolic disorders
0.001 0.066 0.934
H34 Retinal vascular occlusions
0.000 0.070 0.930
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.071 0.929
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.076 0.924
H33 Retinal detachments and breaks
0.000 0.080 0.920
K50-K52 Noninfective enteritis and colitis
0.001 0.082 0.918
H43.3 Other vitreous opacities
0.000 0.082 0.918
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.086 0.914
E10.8 With unspecified complications
0.000 0.089 0.911
K50 Crohn's disease [regional enteritis]
0.000 0.089 0.911
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.090 0.910
M06.4 Inflammatory polyarthropathy
0.000 0.092 0.908
M06.3 Rheumatoid nodule
0.000 0.093 0.907
M35.3 Polymyalgia rheumatica
0.000 0.096 0.904
H20 Iridocyclitis
0.000 0.096 0.904
E83.3 Disorders of phosphorus metabolism
0.899 0.098 0.004
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.098 0.902
H33.3 Retinal breaks without detachment
0.000 0.098 0.902
K74.3 Primary biliary cirrhosis
0.000 0.103 0.897
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.103 0.897
M35 Other systemic involvement of connective tissue
0.000 0.106 0.894
K73 Chronic hepatitis, not elsewhere classified
0.000 0.107 0.893
E88 Other metabolic disorders
0.000 0.112 0.888
M20-M25 Other joint disorders
0.000 0.112 0.888
K50.1 Crohn's disease of large intestine
0.000 0.112 0.888
E07.9 Disorder of thyroid, unspecified
0.000 0.115 0.885
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.116 0.884
G37.8 Other specified demyelinating diseases of central nervous system
0.883 0.116 0.000
H35 Other retinal disorders
0.000 0.120 0.880
L40.8 Other psoriasis
0.000 0.123 0.877
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.000 0.123 0.877
K75.8 Other specified inflammatory liver diseases
0.000 0.129 0.871
E86 Volume depletion
0.000 0.131 0.869
H20.0 Acute and subacute iridocyclitis
0.000 0.133 0.867
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.137 0.863
L80 Vitiligo
0.000 0.142 0.858
L40.1 Generalised pustular psoriasis
0.000 0.145 0.855
K83 Other diseases of biliary tract
0.000 0.147 0.853
E83.5 Disorders of calcium metabolism
0.852 0.147 0.001
H53-H54 Visual disturbances and blindness
0.000 0.154 0.846
M91-M94 Chondropathies
0.000 0.158 0.842
H43.1 Vitreous haemorrhage
0.000 0.158 0.842
E14.1 With ketoacidosis
0.000 0.160 0.840
E10.6 With other specified complications
0.000 0.162 0.838
K83.1 Obstruction of bile duct
0.000 0.162 0.838
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.166 0.834
K74.5 Biliary cirrhosis, unspecified
0.000 0.166 0.834
H35.8 Other specified retinal disorders
0.000 0.170 0.830
E14.6 With other specified complications
0.000 0.173 0.827
E11.8 With unspecified complications
0.000 0.176 0.824
E03.8 Other specified hypothyroidism
0.000 0.180 0.820
K81 Cholecystitis
0.000 0.180 0.820
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.182 0.818
H20.9 Iridocyclitis, unspecified
0.000 0.183 0.817
H33.4 Traction detachment of retina
0.000 0.184 0.816
K81.9 Cholecystitis, unspecified
0.000 0.192 0.808
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.193 0.807
E78.2 Mixed hyperlipidaemia
0.000 0.194 0.806
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.200 0.800
K74.6 Other and unspecified cirrhosis of liver
0.000 0.202 0.798
E14.8 With unspecified complications
0.000 0.202 0.798
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.203 0.797
E83.9 Disorder of mineral metabolism, unspecified
0.782 0.205 0.013
E11.4 With neurological complications
0.000 0.205 0.795
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.207 0.793
H34.2 Other retinal artery occlusions
0.000 0.208 0.792
K83.0 Cholangitis
0.000 0.208 0.792
H43.9 Disorder of vitreous body, unspecified
0.000 0.211 0.789
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.211 0.789
H54 Blindness and low vision
0.000 0.212 0.788
I10 Essential (primary) hypertension
0.000 0.215 0.785
H35.4 Peripheral retinal degeneration
0.000 0.217 0.783
M94 Other disorders of cartilage
0.000 0.221 0.779
M35.1 Other overlap syndromes
0.000 0.223 0.777
K50.8 Other Crohn's disease
0.000 0.224 0.776
E78.6 Lipoprotein deficiency
0.000 0.225 0.775
H43.2 Crystalline deposits in vitreous body
0.000 0.226 0.774
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.227 0.773
L40.3 Pustulosis palmaris et plantaris
0.000 0.229 0.771
K50.0 Crohn's disease of small intestine
0.000 0.229 0.771
H35.2 Other proliferative retinopathy
0.000 0.233 0.767
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.235 0.765
E74 Other disorders of carbohydrate metabolism
0.000 0.237 0.763
H47 Other disorders of optic [2nd] nerve and visual pathways
0.000 0.239 0.761
H34.8 Other retinal vascular occlusions
0.000 0.241 0.759
H46 Optic neuritis
0.000 0.241 0.759
H34.9 Retinal vascular occlusion, unspecified
0.000 0.242 0.758
E14.4 With neurological complications
0.000 0.244 0.756
I10-I15 Hypertensive diseases
0.000 0.245 0.755
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.246 0.754
M86-M90 Other osteopathies
0.000 0.246 0.754
E14.2 Withrenal complications
0.000 0.248 0.752
M06.34 Rheumatoid nodule (Hand)
0.000 0.248 0.752
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.249 0.751
E16.1 Other hypoglycaemia
0.000 0.250 0.750
L10-L14 Bullous disorders
0.000 0.251 0.749
H54.7 Unspecified visual loss
0.000 0.253 0.747
E07.8 Other specified disorders of thyroid
0.000 0.253 0.747
D62 Acute posthaemorrhagic anaemia
0.000 0.254 0.746
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.259 0.741
M34 Systemic sclerosis
0.000 0.259 0.741
L40.4 Guttate psoriasis
0.000 0.262 0.738
E11.5 With peripheral circulatory complications
0.000 0.262 0.737
L85 Other epidermal thickening
0.000 0.264 0.736
K90.9 Intestinal malabsorption, unspecified
0.000 0.265 0.735
D53 Other nutritional anaemias
0.000 0.267 0.733
E13 Other specified diabetes mellitus
0.000 0.270 0.730
M12 Other specific arthropathies
0.000 0.271 0.729
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.275 0.724
M05.2 Rheumatoid vasculitis
0.000 0.276 0.724
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.279 0.721
E88.2 Lipomatosis, not elsewhere classified
0.000 0.280 0.720
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.282 0.718
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.284 0.716
M23 Internal derangement of knee
0.000 0.284 0.716
M23.3 Other meniscus derangements
0.000 0.285 0.715
M07.5 Arthropathy in ulcerative colitis
0.000 0.285 0.714
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.285 0.714
M07.2 Psoriatic spondylitis
0.000 0.285 0.714
M07.1 Arthritis mutilans
0.000 0.285 0.714
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.285 0.714
H43.8 Other disorders of vitreous body
0.000 0.287 0.713
M94.8 Other specified disorders of cartilage
0.000 0.287 0.713
M07.38 Other psoriatic arthropathies (Other)
0.000 0.287 0.713
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.287 0.713
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.287 0.713
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.287 0.713
K71 Toxic liver disease
0.000 0.288 0.712
I12 Hypertensive renal disease
0.000 0.288 0.712
M35.7 Hypermobility syndrome
0.000 0.288 0.712
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.289 0.711
J33.1 Polypoid sinus degeneration
0.000 0.289 0.710
E78.4 Other hyperlipidaemia
0.000 0.290 0.710
H20.1 Chronic iridocyclitis
0.000 0.290 0.710
G36 Other acute disseminated demyelination
0.709 0.291 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.291 0.709
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.291 0.709
K90.1 Tropical sprue
0.000 0.291 0.709
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.291 0.709
G37.5 Concentric sclerosis [Balo]
0.708 0.291 0.000
G37.4 Subacute necrotising myelitis
0.708 0.291 0.000
G37.2 Central pontine myelinolysis
0.708 0.291 0.000
G37.1 Central demyelination of corpus callosum
0.708 0.291 0.000
G37.0 Diffuse sclerosis
0.708 0.291 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.292 0.708
M86 Osteomyelitis
0.000 0.292 0.708
L44 Other papulosquamous disorders
0.000 0.292 0.707
L41 Parapsoriasis
0.000 0.292 0.707
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.292 0.707
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.000 0.292 0.708
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.292 0.707
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.294 0.706
K50.9 Crohn's disease, unspecified
0.000 0.294 0.706
D64.4 Congenital dyserythropoietic anaemia
0.000 0.294 0.705
D64.3 Other sideroblastic anaemias
0.000 0.294 0.705
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.294 0.705
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.294 0.705
D64.0 Hereditary sideroblastic anaemia
0.000 0.294 0.705
E06.5 Other chronic thyroiditis
0.000 0.295 0.705
E06.4 Drug-induced thyroiditis
0.000 0.295 0.705
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.295 0.705
E06.1 Subacute thyroiditis
0.000 0.295 0.705
E06.0 Acute thyroiditis
0.000 0.295 0.705
H15 Disorders of sclera
0.000 0.295 0.705
K77 Liver disorders in diseases classified elsewhere
0.000 0.296 0.704
M06.8 Other specified rheumatoid arthritis
0.000 0.296 0.704
L85.8 Other specified epidermal thickening
0.000 0.296 0.704
H34.1 Central retinal artery occlusion
0.000 0.296 0.704
M07.6 Other enteropathic arthropathies
0.000 0.297 0.703
I12.9 Hypertensive renal disease without renal failure
0.000 0.298 0.702
K72 Hepatic failure, not elsewhere classified
0.000 0.298 0.701
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.299 0.701
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.301 0.699
K75.2 Nonspecific reactive hepatitis
0.000 0.302 0.698
K75.1 Phlebitis of portal vein
0.000 0.302 0.698
L84 Corns and callosities
0.000 0.305 0.695
E78.1 Pure hyperglyceridaemia
0.000 0.305 0.695
D50.1 Sideropenic dysphagia
0.000 0.307 0.693
D51 Vitamin B12 deficiency anaemia
0.000 0.307 0.693
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.309 0.691
E88.8 Other specified metabolic disorders
0.000 0.310 0.690
E83.8 Other disorders of mineral metabolism
0.672 0.311 0.017
E83.2 Disorders of zinc metabolism
0.672 0.311 0.017
E83.0 Disorders of copper metabolism
0.672 0.311 0.017
H54.0 Blindness, both eyes
0.000 0.312 0.688
E06.9 Thyroiditis, unspecified
0.000 0.315 0.685
H35.7 Separation of retinal layers
0.000 0.315 0.685
K74.4 Secondary biliary cirrhosis
0.000 0.324 0.676
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.324 0.676
H30 Chorioretinal inflammation
0.000 0.324 0.676
E07.1 Dyshormogenetic goitre
0.000 0.325 0.675
E07.0 Hypersecretion of calcitonin
0.000 0.325 0.675
M65-M68 Disorders of synovium and tendon
0.000 0.325 0.675
H35.6 Retinal haemorrhage
0.000 0.325 0.675
E14.5 With peripheral circulatory complications
0.000 0.326 0.674
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.328 0.671
H43.0 Vitreous prolapse
0.000 0.329 0.671
E70 Disorders of aromatic amino-acid metabolism
0.001 0.329 0.671
M86.9 Osteomyelitis, unspecified
0.000 0.329 0.671
E77 Disorders of glycoprotein metabolism
0.001 0.330 0.669
E76 Disorders of glycosaminoglycan metabolism
0.001 0.330 0.669
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.330 0.669
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.330 0.669
H47.2 Optic atrophy
0.000 0.330 0.670
H16 Keratitis
0.000 0.331 0.669
H34.0 Transient retinal artery occlusion
0.000 0.333 0.667
M35.2 Behcet's disease
0.000 0.333 0.667
H33.1 Retinoschisis and retinal cysts
0.000 0.334 0.665
E78.8 Other disorders of lipoprotein metabolism
0.000 0.335 0.665
E40-E46 Malnutrition
0.000 0.335 0.664
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.340 0.660
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.342 0.658
Chapter VIII Diseases of the ear and mastoid process
0.000 0.342 0.658
K73.9 Chronic hepatitis, unspecified
0.000 0.342 0.658
L83 Acanthosis nigricans
0.000 0.345 0.655
M34.1 CR(E)ST syndrome
0.000 0.347 0.653
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.348 0.652
L87 Transepidermal elimination disorders
0.000 0.348 0.652
L86 Keratoderma in diseases classified elsewhere
0.000 0.348 0.652
L95.8 Other vasculitis limited to skin
0.000 0.348 0.651
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.349 0.651
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.349 0.651
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.349 0.651
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.349 0.651
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.349 0.651
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.349 0.651
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.349 0.651
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.349 0.651
E78.0 Pure hypercholesterolaemia
0.000 0.349 0.651
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.350 0.650
M06.38 Rheumatoid nodule (Other)
0.000 0.350 0.650
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.350 0.650
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.350 0.650
M06.33 Rheumatoid nodule (Forearm)
0.000 0.350 0.650
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.350 0.650
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.350 0.650
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.000 0.350 0.650
Chapter IX Diseases of the circulatory system
0.000 0.351 0.649
H20.2 Lens-induced iridocyclitis
0.000 0.352 0.648
M14 Arthropathies in other diseases classified elsewhere
0.000 0.354 0.646
E11.6 With other specified complications
0.000 0.354 0.646
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.000 0.357 0.643
K81.1 Chronic cholecystitis
0.000 0.357 0.643
E88.3 Tumour lysis syndrome
0.000 0.358 0.641
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.359 0.641
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.359 0.641
M35.5 Multifocal fibrosclerosis
0.000 0.359 0.641
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.359 0.641
M60-M63 Disorders of muscles
0.000 0.359 0.641
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.640 0.360 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.360 0.640
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.360 0.640
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.000 0.360 0.640
M23.30 Other meniscus derangements (Multiple sites)
0.000 0.363 0.637
K75.9 Inflammatory liver disease, unspecified
0.000 0.364 0.636
E88.9 Metabolic disorder, unspecified
0.000 0.365 0.635
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.365 0.635
M10 Gout
0.000 0.366 0.634
E78.3 Hyperchylomicronaemia
0.000 0.366 0.634
M00-M03 Infectious arthropathies
0.000 0.366 0.634
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.367 0.633
H35.1 Retinopathy of prematurity
0.000 0.369 0.631
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.000 0.370 0.630
L92.0 Granuloma annulare
0.000 0.370 0.630
M94.88 Other specified disorders of cartilage (Other)
0.000 0.370 0.630
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.000 0.371 0.629
D80-D89 Certain disorders involving the immune mechanism
0.000 0.376 0.624
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.000 0.377 0.623
E89.0 Postprocedural hypothyroidism
0.000 0.378 0.622
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.000 0.378 0.622
H54.2 Low vision, both eyes
0.000 0.381 0.619
H40-H42 Glaucoma
0.000 0.382 0.618
E11.0 With coma
0.000 0.382 0.618
I11 Hypertensive heart disease
0.000 0.382 0.618
E79 Disorders of purine and pyrimidine metabolism
0.001 0.383 0.617
H60-H62 Diseases of external ear
0.000 0.385 0.615
E05.8 Other thyrotoxicosis
0.000 0.385 0.615
M94.2 Chondromalacia
0.000 0.386 0.614
K83.5 Biliary cyst
0.000 0.388 0.612
K83.2 Perforation of bile duct
0.000 0.388 0.612
K83.4 Spasm of sphincter of Oddi
0.000 0.389 0.611
L13 Other bullous disorders
0.000 0.389 0.611
E72 Other disorders of amino-acid metabolism
0.001 0.390 0.610
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.390 0.610
L93 Lupus erythematosus
0.000 0.394 0.606
E03.1 Congenital hypothyroidism without goitre
0.000 0.395 0.605
L94 Other localised connective tissue disorders
0.000 0.395 0.605
H18 Other disorders of cornea
0.000 0.395 0.605
M91 Juvenile osteochondrosis of hip and pelvis
0.000 0.396 0.604
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.397 0.603
E85 Amyloidosis
0.000 0.398 0.602
H35.5 Hereditary retinal dystrophy
0.000 0.398 0.602
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.398 0.602
E73 Lactose intolerance
0.001 0.399 0.600
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.000 0.401 0.599
M94.86 Other specified disorders of cartilage (Lower leg)
0.000 0.401 0.599
L90 Atrophic disorders of skin
0.000 0.402 0.598
M33 Dermatopolymyositis
0.000 0.404 0.596
E84 Cystic fibrosis
0.001 0.414 0.586
H54.1 Blindness, one eye, low vision, other eye
0.000 0.419 0.581
K86 Other diseases of pancreas
0.000 0.420 0.580
M94.9 Disorder of cartilage, unspecified
0.000 0.423 0.577
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.425 0.575
E65-E68 Obesity and other hyperalimentation
0.000 0.426 0.574
H47.3 Other disorders of optic disk
0.000 0.427 0.573
M12.3 Palindromic rheumatism
0.000 0.428 0.571
M65 Synovitis and tenosynovitis
0.000 0.429 0.571
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.431 0.569
L92.2 Granuloma faciale [eosinophilic granuloma of skin]
0.000 0.431 0.569
L92.1 Necrobiosis lipoidica, not elsewhere classified
0.000 0.431 0.569
H47.1 Papilloedema, unspecified
0.000 0.432 0.568
H15.8 Other disorders of sclera
0.000 0.433 0.567
H61 Other disorders of external ear
0.000 0.433 0.567
H44 Disorders of globe
0.001 0.433 0.566
M86.6 Other chronic osteomyelitis
0.000 0.433 0.567
M94.85 Other specified disorders of cartilage (Pelvic region and thigh)
0.000 0.435 0.565
H54.3 Unqualified visual loss, both eyes
0.000 0.435 0.565
M93 Other osteochondropathies
0.000 0.436 0.564
L88 Pyoderma gangrenosum
0.000 0.437 0.563
H54.5 Low vision, one eye
0.000 0.440 0.560
E13.9 Without complications
0.000 0.440 0.560
M32 Systemic lupus erythematosus
0.000 0.440 0.559
M94.3 Chondrolysis
0.000 0.441 0.559
M94.1 Relapsing polychondritis
0.000 0.441 0.559
M94.0 Chondrocostal junction syndrome [Tietze]
0.000 0.441 0.559
K72.9 Hepatic failure, unspecified
0.000 0.443 0.557
D53.9 Nutritional anaemia, unspecified
0.000 0.445 0.555
K74.1 Hepatic sclerosis
0.000 0.446 0.554
H54.6 Unqualified visual loss, one eye
0.000 0.448 0.552
H18.4 Corneal degeneration
0.000 0.449 0.551
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.451 0.548
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.453 0.547
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.453 0.547
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.453 0.547
E74.2 Disorders of galactose metabolism
0.000 0.453 0.547
E74.1 Disorders of fructose metabolism
0.000 0.453 0.547
E74.0 Glycogen storage disease
0.000 0.453 0.547
M35.8 Other specified systemic involvement of connective tissue
0.000 0.453 0.547
M23.0 Cystic meniscus
0.000 0.454 0.546
H47.7 Disorder of visual pathways, unspecified
0.000 0.454 0.546
H47.6 Disorders of visual cortex
0.000 0.454 0.546
H47.5 Disorders of other visual pathways
0.000 0.454 0.546
H47.4 Disorders of optic chiasm
0.000 0.454 0.546
M45-M49 Spondylopathies
0.000 0.456 0.544
M31 Other necrotising vasculopathies
0.000 0.457 0.543
M11 Other crystal arthropathies
0.000 0.457 0.542
D52 Folate deficiency anaemia
0.000 0.458 0.542
D86 Sarcoidosis
0.000 0.458 0.542
K83.3 Fistula of bile duct
0.000 0.460 0.540
D64.8 Other specified anaemias
0.000 0.461 0.539
H21 Other disorders of iris and ciliary body
0.000 0.461 0.539
L10 Pemphigus
0.000 0.463 0.537
L14 Bullous disorders in diseases classified elsewhere
0.000 0.463 0.537
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.463 0.537
K86.0 Alcohol-induced chronic pancreatitis
0.000 0.464 0.536
M34.9 Systemic sclerosis, unspecified
0.000 0.465 0.535
H61.0 Perichondritis of external ear
0.000 0.466 0.534
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.467 0.533
H15.1 Episcleritis
0.000 0.467 0.533
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.469 0.531
L12 Pemphigoid
0.000 0.470 0.530
M88 Paget's disease of bone [osteitis deformans]
0.000 0.471 0.529
L85.3 Xerosis cutis
0.000 0.473 0.527
L85.2 Keratosis punctata (palmaris et plantaris)
0.000 0.473 0.527
L85.0 Acquired ichthyosis
0.000 0.473 0.527
M05.29 Rheumatoid vasculitis (Site unspecified)
0.000 0.474 0.526
D53.8 Other specified nutritional anaemias
0.000 0.474 0.525
D53.2 Scorbutic anaemia
0.000 0.474 0.525
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.474 0.525
D53.0 Protein deficiency anaemia
0.000 0.474 0.525
E13.8 With unspecified complications
0.000 0.477 0.523
E13.7 With multiple complications
0.000 0.477 0.523
E13.6 With other specified complications
0.000 0.477 0.523
E13.5 With peripheral circulatory complications
0.000 0.477 0.523
E13.4 With neurological complications
0.000 0.477 0.523
E13.2 With renal complications
0.000 0.477 0.523

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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