TreeWAS – Variant ID: rs4380275

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E11.9 Without complications	0.716	0.284	0.000
E11 Non-insulin-dependent diabetes mellitus	0.715	0.285	0.000
E10-E14 Diabetes mellitus	0.704	0.296	0.000
E14 Unspecified diabetes mellitus	0.689	0.311	0.000
E11.3 With ophthalmic complications	0.674	0.326	0.000
E10 Insulin-dependent diabetes mellitus	0.669	0.331	0.000
E14.3 With ophthalmic complications	0.667	0.333	0.000
E11.1 With ketoacidosis	0.658	0.342	0.000
E10.5 With peripheral circulatory complications	0.656	0.344	0.000
E14.5 With peripheral circulatory complications	0.597	0.403	0.000
E10.2 With renal complications	0.589	0.411	0.000
E14.4 With neurological complications	0.586	0.414	0.000
E11.0 With coma	0.566	0.434	0.000
E10.8 With unspecified complications	0.562	0.438	0.000
E11.6 With other specified complications	0.555	0.445	0.000
E10.4 With neurological complications	0.553	0.447	0.000
E13 Other specified diabetes mellitus	0.532	0.468	0.000
E11.7 With multiple complications	0.512	0.488	0.000
E14.6 With other specified complications	0.508	0.491	0.000
E10.7 With multiple complications	0.506	0.494	0.000
E12 Malnutrition-related diabetes mellitus	0.505	0.495	0.000
E14.1 With ketoacidosis	0.498	0.502	0.000
E14.7 With multiple complications	0.494	0.506	0.000
E11.5 With peripheral circulatory complications	0.493	0.506	0.000
E14.0 With coma	0.487	0.513	0.000
E14.8 With unspecified complications	0.469	0.530	0.000
E10.0 With coma	0.459	0.541	0.000
E10.1 With ketoacidosis	0.456	0.544	0.000
E11.2 With renal complications	0.451	0.549	0.000
E14.2 Withrenal complications	0.450	0.550	0.000
E13.9 Without complications	0.438	0.562	0.000
E10.6 With other specified complications	0.420	0.580	0.000
E14.9 Without complications	0.386	0.614	0.000
E13.8 With unspecified complications	0.382	0.618	0.000
E13.7 With multiple complications	0.382	0.618	0.000
E13.6 With other specified complications	0.382	0.618	0.000
E13.5 With peripheral circulatory complications	0.382	0.618	0.000
E13.4 With neurological complications	0.382	0.618	0.000
E13.2 With renal complications	0.382	0.618	0.000
E13.1 With ketoacidosis	0.382	0.618	0.000
E13.0 With coma	0.382	0.618	0.000
E12.9 Without complications	0.362	0.638	0.000
E12.8 With unspecified complications	0.362	0.638	0.000
E12.7 With multiple complications	0.362	0.638	0.000
E12.6 With other specified complications	0.362	0.638	0.000
E12.5 With peripheral circulatory complications	0.362	0.638	0.000
E12.4 With neurological complications	0.362	0.638	0.000
E12.3 With ophthalmic complications	0.362	0.638	0.000
E12.2 With renal complications	0.362	0.638	0.000
E12.1 With ketoacidosis	0.362	0.638	0.000
E12.0 With coma	0.362	0.638	0.000
E13.3 With ophthalmic complications	0.336	0.664	0.000
E11.8 With unspecified complications	0.262	0.737	0.001
E11.4 With neurological complications	0.237	0.763	0.000
E10.3 With ophthalmic complications	0.196	0.804	0.000
E10.9 Without complications	0.055	0.945	0.000
K76.9 Liver disease, unspecified	0.000	0.958	0.042
M19.90 Arthrosis, unspecified (Multiple sites)	0.039	0.961	0.000
J92.0 Pleural plaque with presence of asbestos	0.023	0.977	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.015	0.985	0.000
E40-E46 Malnutrition	0.014	0.986	0.000
E46 Unspecified protein-energy malnutrition	0.014	0.986	0.000
E65-E68 Obesity and other hyperalimentation	0.011	0.989	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.010	0.990	0.000
E45 Retarded development following protein-energy malnutrition	0.010	0.990	0.000
E43 Unspecified severe protein-energy malnutrition	0.010	0.990	0.000
E42 Marasmic kwashiorkor	0.010	0.990	0.000
E41 Nutritional marasmus	0.010	0.990	0.000
E40 Kwashiorkor	0.010	0.990	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.010	0.990	0.000
L03.0 Cellulitis of finger and toe	0.009	0.991	0.000
E65 Localised adiposity	0.009	0.991	0.000
J92 Pleural plaque	0.009	0.991	0.000
E67 Other hyperalimentation	0.008	0.992	0.000
E68 Sequelae of hyperalimentation	0.008	0.992	0.000
E44.1 Mild protein-energy malnutrition	0.007	0.992	0.000
E44.0 Moderate protein-energy malnutrition	0.007	0.992	0.000
E15 Nondiabetic hypoglycaemic coma	0.007	0.993	0.000
E66 Obesity	0.007	0.993	0.000
M54.96 Dorsalgia, unspecified (Lumbar region)	0.007	0.993	0.000
J39.8 Other specified diseases of upper respiratory tract	0.000	0.993	0.007
G91.1 Obstructive hydrocephalus	0.000	0.994	0.006
E67.8 Other specified hyperalimentation	0.006	0.994	0.000
E67.3 Hypervitaminosis D	0.006	0.994	0.000
E67.2 Megavitamin-B6 syndrome	0.006	0.994	0.000
E67.1 Hypercarotenaemia	0.006	0.994	0.000
E67.0 Hypervitaminosis A	0.006	0.994	0.000
E66.2 Extreme obesity with alveolar hypoventilation	0.006	0.994	0.000
E21.3 Hyperparathyroidism, unspecified	0.000	0.994	0.006
E16 Other disorders of pancreatic internal secretion	0.006	0.994	0.000
E66.8 Other obesity	0.006	0.994	0.000
J39.9 Disease of upper respiratory tract, unspecified	0.000	0.994	0.006
Z87.8 Personal history of other specified conditions	0.006	0.994	0.000
K86.1 Other chronic pancreatitis	0.006	0.994	0.000
E50-E64 Other nutritional deficiencies	0.006	0.994	0.000
E66.0 Obesity due to excess calories	0.006	0.994	0.000
K76.8 Other specified diseases of liver	0.000	0.994	0.006
K76 Other diseases of liver	0.000	0.994	0.006
J39 Other diseases of upper respiratory tract	0.000	0.994	0.006
E66.1 Drug-induced obesity	0.005	0.994	0.000
J92.9 Pleural plaque without asbestos	0.005	0.995	0.000
J39.0 Retropharyngeal and parapharyngeal abscess	0.000	0.995	0.005
C01 Malignant neoplasm of base of tongue	0.000	0.995	0.005
E16.9 Disorder of pancreatic internal secretion, unspecified	0.004	0.995	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.004	0.995	0.000
E16.4 Abnormal secretion of gastrin	0.004	0.995	0.000
E16.3 Increased secretion of glucagon	0.004	0.995	0.000
E56 Other vitamin deficiencies	0.004	0.995	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.004	0.996	0.000
E50 Vitamin A deficiency	0.004	0.996	0.000
E60 Dietary zinc deficiency	0.004	0.996	0.000
E59 Dietary selenium deficiency	0.004	0.996	0.000
E52 Niacin deficiency [pellagra]	0.004	0.996	0.000
K76.3 Infarction of liver	0.000	0.996	0.004
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.004	0.996	0.000
E16.0 Drug-induced hypoglycaemia without coma	0.004	0.996	0.000
G91 Hydrocephalus	0.000	0.996	0.004
K76.5 Hepatic veno-occlusive disease	0.000	0.996	0.004
K76.4 Peliosis hepatis	0.000	0.996	0.004
K76.2 Central haemorrhagic necrosis of liver	0.000	0.996	0.004
J39.3 Upper respiratory tract hypersensitivity reaction, site unspecified	0.000	0.996	0.004
E58 Dietary calcium deficiency	0.004	0.996	0.000
E54 Ascorbic acid deficiency	0.004	0.996	0.000
G91.9 Hydrocephalus, unspecified	0.000	0.996	0.004
E61 Deficiency of other nutrient elements	0.004	0.996	0.000
Z80.9 Family history of malignant neoplasm, unspecified	0.004	0.996	0.000
E63 Other nutritional deficiencies	0.004	0.996	0.000
J39.1 Other abscess of pharynx	0.000	0.996	0.004
E16.2 Hypoglycaemia, unspecified	0.004	0.996	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.004	0.996	0.000
E16.1 Other hypoglycaemia	0.004	0.996	0.000
F10.1 Harmful use	0.004	0.996	0.000
E55 Vitamin D deficiency	0.004	0.996	0.000
E51 Thiamine deficiency	0.004	0.996	0.000
K76.1 Chronic passive congestion of liver	0.000	0.996	0.004
N93.8 Other specified abnormal uterine and vaginal bleeding	0.000	0.996	0.004
G91.0 Communicating hydrocephalus	0.000	0.996	0.004
K60.1 Chronic anal fissure	0.004	0.996	0.000
E61.2 Magnesium deficiency	0.004	0.996	0.000
E56.1 Deficiency of vitamin K	0.003	0.996	0.000
V89.9 Person injured in unspecified vehicle accident	0.000	0.996	0.004
E56.9 Vitamin deficiency, unspecified	0.003	0.996	0.000
E56.8 Deficiency of other vitamins	0.003	0.996	0.000
E56.0 Deficiency of vitamin E	0.003	0.996	0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.004	0.996	0.000
E50.9 Vitamin A deficiency, unspecified	0.003	0.997	0.000
E50.8 Other manifestations of vitamin A deficiency	0.003	0.997	0.000
E50.7 Other ocular manifestations of vitamin A deficiency	0.003	0.997	0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.003	0.997	0.000
E50.5 Vitamin A deficiency with night blindness	0.003	0.997	0.000
E50.4 Vitamin A deficiency with keratomalacia	0.003	0.997	0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.003	0.997	0.000
E50.2 Vitamin A deficiency with corneal xerosis	0.003	0.997	0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.003	0.997	0.000
E50.0 Vitamin A deficiency with conjunctival xerosis	0.003	0.997	0.000
E64.9 Sequelae of unspecified nutritional deficiency	0.003	0.997	0.000
E64.8 Sequelae of other nutritional deficiencies	0.003	0.997	0.000
E64.3 Sequelae of rickets	0.003	0.997	0.000
E64.2 Sequelae of vitamin C deficiency	0.003	0.997	0.000
E64.1 Sequelae of vitamin A deficiency	0.003	0.997	0.000
E64.0 Sequelae of protein-energy malnutrition	0.003	0.997	0.000
K60.3 Anal fistula	0.003	0.997	0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.003	0.997	0.000
G91.3 Posttraumatic hydrocephalus, unspecified	0.000	0.997	0.003
E61.9 Deficiency of nutrient element, unspecified	0.003	0.997	0.000
E61.8 Deficiency of other specified nutrient elements	0.003	0.997	0.000
E61.7 Deficiency of multiple nutrient elements	0.003	0.997	0.000
E61.6 Vanadium deficiency	0.003	0.997	0.000
E61.5 Molybdenum deficiency	0.003	0.997	0.000
E61.4 Chromium deficiency	0.003	0.997	0.000
E61.3 Manganese deficiency	0.003	0.997	0.000
E61.0 Copper deficiency	0.003	0.997	0.000
G91.2 Normal-pressure hydrocephalus	0.000	0.997	0.003
J39.2 Other diseases of pharynx	0.000	0.997	0.003
K76.7 Hepatorenal syndrome	0.000	0.997	0.003
F23.9 Acute and transient psychotic disorder, unspecified	0.000	0.997	0.003
E63.8 Other specified nutritional deficiencies	0.003	0.997	0.000
E63.1 Imbalance of constituents of food intake	0.003	0.997	0.000
E63.0 Essential fatty acid [EFA] deficiency	0.003	0.997	0.000
E53 Deficiency of other B group vitamins	0.003	0.997	0.000
G91.8 Other hydrocephalus	0.000	0.997	0.003
E55.0 Rickets, active	0.003	0.997	0.000
M85.8 Other specified disorders of bone density and structure	0.003	0.997	0.000
V89.2 Person injured in unspecified motor-vehicle accident, traffic	0.000	0.997	0.003
K60 Fissure and fistula of anal and rectal regions	0.003	0.997	0.000
H90.3 Sensorineural hearing loss, bilateral	0.003	0.997	0.000
Y48.3 Local anaesthetics	0.000	0.997	0.003
E51.9 Thiamine deficiency, unspecified	0.003	0.997	0.000
E51.8 Other manifestations of thiamine deficiency	0.003	0.997	0.000
E51.1 Beriberi	0.003	0.997	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.997	0.003
K60.2 Anal fissure, unspecified	0.003	0.997	0.000
E63.9 Nutritional deficiency, unspecified	0.003	0.997	0.000
G31.8 Other specified degenerative diseases of nervous system	0.000	0.997	0.003
M85 Other disorders of bone density and structure	0.003	0.997	0.000
M85.0 Fibrous dysplasia (monostotic)	0.003	0.997	0.000
G82.5 Tetraplegia, unspecified	0.003	0.997	0.000
K04.6 Periapical abscess with sinus	0.000	0.997	0.003
V89 Motor- or nonmotor-vehicle accident, type of vehicle unspecified	0.000	0.997	0.003
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.003	0.997	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.003	0.997	0.000
S32.50 Fracture of pubis (closed)	0.000	0.997	0.003
T42.4 Benzodiazepines	0.000	0.997	0.003
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.003	0.997	0.000
M85.9 Disorder of bone density and structure, unspecified	0.003	0.997	0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)	0.003	0.997	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.997	0.003
E21.0 Primary hyperparathyroidism	0.000	0.997	0.003
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.003	0.997	0.000
C06 Malignant neoplasm of other and unspecified parts of mouth	0.000	0.997	0.003
K60.5 Anorectal fistula	0.003	0.997	0.000
E53.1 Pyridoxine deficiency	0.002	0.997	0.000
E53.0 Riboflavin deficiency	0.002	0.997	0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.002	0.997	0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.003	0.997	0.000
C06.9 Mouth, unspecified	0.000	0.997	0.002
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.000	0.997	0.003
M85.84 Other specified disorders of bone density and structure (Hand)	0.002	0.997	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.002	0.997	0.000
E51.2 Wernicke's encephalopathy	0.002	0.997	0.001
M85.4 Solitary bone cyst	0.002	0.997	0.000
M85.98 Disorder of bone density and structure, unspecified (Other)	0.002	0.998	0.000
E55.9 Vitamin D deficiency, unspecified	0.002	0.998	0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs	0.002	0.998	0.000
D89.2 Hypergammaglobulinaemia, unspecified	0.000	0.998	0.002
E61.1 Iron deficiency	0.002	0.998	0.000
K60.0 Acute anal fissure	0.002	0.998	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.002	0.998	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.002	0.998	0.000
G03.9 Meningitis, unspecified	0.000	0.998	0.002
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.002	0.998	0.000
C06.0 Cheek mucosa	0.000	0.998	0.002
E53.9 Vitamin B deficiency, unspecified	0.002	0.998	0.000
H40.2 Primary angle-closure glaucoma	0.000	0.998	0.002
M80.9 Unspecified osteoporosis with pathological fracture	0.002	0.998	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.002	0.998	0.000
M85.5 Aneurysmal bone cyst	0.002	0.998	0.000
M85.3 Osteitis condensans	0.002	0.998	0.000
M85.1 Skeletal fluorosis	0.002	0.998	0.000
C10 Malignant neoplasm of oropharynx	0.000	0.998	0.002
M85.85 Other specified disorders of bone density and structure (Pelvic region and thigh)	0.002	0.998	0.000
H40.0 Glaucoma suspect	0.000	0.998	0.002
M80 Osteoporosis with pathological fracture	0.002	0.998	0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.002	0.998	0.000
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.002	0.998	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.002	0.998	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.002	0.998	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.002	0.998	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.002	0.998	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.002	0.998	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.002	0.998	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.002	0.998	0.000
C10.9 Oropharynx, unspecified	0.000	0.998	0.002
M85.88 Other specified disorders of bone density and structure (Other)	0.002	0.998	0.000
V89.3 Person injured in unspecified nonmotor-vehicle accident, traffic	0.000	0.998	0.002
V89.1 Person injured in unspecified nonmotor-vehicle accident, nontraffic	0.000	0.998	0.002
V89.0 Person injured in unspecified motor-vehicle accident, nontraffic	0.000	0.998	0.002
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.002	0.998	0.000
M85.2 Hyperostosis of skull	0.002	0.998	0.000
C00 Malignant neoplasm of lip	0.000	0.998	0.002
O26.8 Other specified pregnancy-related conditions	0.000	0.998	0.002
M85.6 Other cyst of bone	0.002	0.998	0.000
C13 Malignant neoplasm of hypopharynx	0.000	0.998	0.002
C00.0 External upper lip	0.000	0.998	0.002
S91.3 Open wound of other parts of foot	0.000	0.998	0.002
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.002	0.998	0.000
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.002	0.998	0.000
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.002	0.998	0.000
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.002	0.998	0.000
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.002	0.998	0.000
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.002	0.998	0.000
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.002	0.998	0.000
T45.5 Anticoagulants	0.000	0.998	0.002
E21.4 Other specified disorders of parathyroid gland	0.000	0.998	0.002
T42.1 Iminostilbenes	0.000	0.998	0.002
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.000	0.998	0.002
C06.2 Retromolar area	0.000	0.998	0.002
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.998	0.002
O36.5 Maternal care for poor foetal growth	0.002	0.998	0.000
E21.2 Other hyperparathyroidism	0.000	0.998	0.002
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.002	0.998	0.000
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.002	0.998	0.000
C06.8 Overlapping lesion of other and unspecified parts of mouth	0.000	0.998	0.002
C06.1 Vestibule of mouth	0.000	0.998	0.002
Q76.0 Spina bifida occulta	0.002	0.998	0.000
C08 Malignant neoplasm of other and unspecified major salivary glands	0.000	0.998	0.002
C07 Malignant neoplasm of parotid gland	0.000	0.998	0.002
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.002	0.998	0.000
K76.6 Portal hypertension	0.000	0.998	0.002
M80.5 Idiopathic osteoporosis with pathological fracture	0.002	0.998	0.000
M18 Arthrosis of first carpometacarpal joint	0.002	0.998	0.000
M85.46 Solitary bone cyst (Lower leg)	0.002	0.998	0.000
M85.66 Other cyst of bone (Lower leg)	0.002	0.998	0.000
M80.8 Other osteoporosis with pathological fracture	0.002	0.998	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.000	0.998	0.002
Z81.8 Family history of other mental and behavioural disorders	0.000	0.998	0.002
M70.56 Other bursitis of knee-Lower Leg	0.002	0.998	0.000
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.002	0.998	0.000
M85.49 Solitary bone cyst (Site unspecified)	0.002	0.998	0.000
M85.48 Solitary bone cyst (Other)	0.002	0.998	0.000
M85.47 Solitary bone cyst (Ankle and foot)	0.002	0.998	0.000
M85.44 Solitary bone cyst (Hand)	0.002	0.998	0.000
M85.43 Solitary bone cyst (Forearm)	0.002	0.998	0.000
M85.42 Solitary bone cyst (Upper arm)	0.002	0.998	0.000
M85.41 Solitary bone cyst (Shoulder region)	0.002	0.998	0.000
M85.40 Solitary bone cyst (Multiple sites)	0.002	0.998	0.000
W49.9 Unspecified place	0.002	0.998	0.000
C13.0 Postcricoid region	0.000	0.998	0.002
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.002	0.998	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.002	0.998	0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.002	0.998	0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.002	0.998	0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.002	0.998	0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.002	0.998	0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.002	0.998	0.000
C13.9 Hypopharynx, unspecified	0.000	0.998	0.002
C12 Malignant neoplasm of pyriform sinus	0.000	0.998	0.002
M80.88 Other osteoporosis with pathological fracture (Other)	0.002	0.998	0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.002	0.998	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.002	0.998	0.000
M24.27 Disorder of ligament (Ankle and foot)	0.000	0.998	0.002
M85.19 Skeletal fluorosis (Site unspecified)	0.002	0.998	0.000
M85.18 Skeletal fluorosis (Other)	0.002	0.998	0.000
M85.17 Skeletal fluorosis (Ankle and foot)	0.002	0.998	0.000
M85.16 Skeletal fluorosis (Lower leg)	0.002	0.998	0.000
M85.15 Skeletal fluorosis (Pelvic region and thigh)	0.002	0.998	0.000
M85.14 Skeletal fluorosis (Hand)	0.002	0.998	0.000
M85.13 Skeletal fluorosis (Forearm)	0.002	0.998	0.000
M85.12 Skeletal fluorosis (Upper arm)	0.002	0.998	0.000
M85.11 Skeletal fluorosis (Shoulder region)	0.002	0.998	0.000
M85.10 Skeletal fluorosis (Multiple sites)	0.002	0.998	0.000
M85.39 Osteitis condensans (Site unspecified)	0.002	0.998	0.000
M85.38 Osteitis condensans (Other)	0.002	0.998	0.000
M85.37 Osteitis condensans (Ankle and foot)	0.002	0.998	0.000
M85.36 Osteitis condensans (Lower leg)	0.002	0.998	0.000
M85.35 Osteitis condensans (Pelvic region and thigh)	0.002	0.998	0.000
M85.34 Osteitis condensans (Hand)	0.002	0.998	0.000
M85.33 Osteitis condensans (Forearm)	0.002	0.998	0.000
M85.32 Osteitis condensans (Upper arm)	0.002	0.998	0.000
M85.31 Osteitis condensans (Shoulder region)	0.002	0.998	0.000
M85.30 Osteitis condensans (Multiple sites)	0.002	0.998	0.000
M85.59 Aneurysmal bone cyst (Site unspecified)	0.002	0.998	0.000
M85.58 Aneurysmal bone cyst (Other)	0.002	0.998	0.000
M85.57 Aneurysmal bone cyst (Ankle and foot)	0.002	0.998	0.000
M85.56 Aneurysmal bone cyst (Lower leg)	0.002	0.998	0.000
M85.55 Aneurysmal bone cyst (Pelvic region and thigh)	0.002	0.998	0.000
M85.54 Aneurysmal bone cyst (Hand)	0.002	0.998	0.000
M85.53 Aneurysmal bone cyst (Forearm)	0.002	0.998	0.000
M85.52 Aneurysmal bone cyst (Upper arm)	0.002	0.998	0.000
M85.51 Aneurysmal bone cyst (Shoulder region)	0.002	0.998	0.000
M85.50 Aneurysmal bone cyst (Multiple sites)	0.002	0.998	0.000
C00.9 Lip, unspecified	0.000	0.998	0.002
C10.8 Overlapping lesion of oropharynx	0.000	0.998	0.002
C10.4 Branchial cleft	0.000	0.998	0.002
C10.3 Posterior wall of oropharynx	0.000	0.998	0.002
C10.2 Lateral wall of oropharynx	0.000	0.998	0.002
C10.1 Anterior surface of epiglottis	0.000	0.998	0.002
C10.0 Vallecula	0.000	0.998	0.002
C04 Malignant neoplasm of floor of mouth	0.000	0.998	0.002
M85.22 Hyperostosis of skull-Upper arm	0.002	0.998	0.000
I45.9 Conduction disorder, unspecified	0.002	0.998	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.002	0.998	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.002	0.998	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.002	0.998	0.000
C03 Malignant neoplasm of gum	0.000	0.998	0.002
N77.1 Vaginitis, vulvitis and vulvovaginitis in infectious and parasitic diseases classified elsewhere	0.002	0.998	0.000
Z41.1 Other plastic surgery for unacceptable cosmetic appearance	0.002	0.998	0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.002	0.998	0.000
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.002	0.998	0.000
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.002	0.998	0.000
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.002	0.998	0.000
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.002	0.998	0.000
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.002	0.998	0.000
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.002	0.998	0.000
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.002	0.998	0.000
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.002	0.998	0.000
M85.29 Hyperostosis of skull-Site unspec	0.002	0.998	0.000
M85.28 Hyperostosis of skull-Other	0.002	0.998	0.000
M85.27 Hyperostosis of skull-Ankle/Foot	0.002	0.998	0.000
M85.26 Hyperostosis of skull-Lower Leg	0.002	0.998	0.000
M85.25 Hyperostosis of skull-Pelvic/Thigh	0.002	0.998	0.000
M85.24 Hyperostosis of skull-Hand	0.002	0.998	0.000
M85.23 Hyperostosis of skull-Forearm	0.002	0.998	0.000
M85.21 Hyperostosis of skull-Shldr region	0.002	0.998	0.000
M85.64 Other cyst of bone (Hand)	0.002	0.998	0.000
C00.8 Overlapping lesion of lip	0.000	0.998	0.002
C00.6 Commissure of lip	0.000	0.998	0.002
C00.5 Lip, unspecified, inner aspect	0.000	0.998	0.002
C00.4 Lower lip, inner aspect	0.000	0.998	0.002
C00.3 Upper lip, inner aspect	0.000	0.998	0.002
C00.2 External lip, unspecified	0.000	0.998	0.002
T47.1 Other antacids and anti-gastric-secretion drugs	0.000	0.998	0.002
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.002	0.998	0.000
M85.69 Other cyst of bone (Site unspecified)	0.002	0.998	0.000
M85.63 Other cyst of bone (Forearm)	0.002	0.998	0.000
M85.62 Other cyst of bone (Upper arm)	0.002	0.998	0.000
M85.61 Other cyst of bone (Shoulder region)	0.002	0.998	0.000
M85.60 Other cyst of bone (Multiple sites)	0.002	0.998	0.000
C13.8 Overlapping lesion of hypopharynx	0.000	0.998	0.002
C13.2 Posterior wall of hypopharynx	0.000	0.998	0.002
C13.1 Aryepiglottic fold, hypopharyngeal aspect	0.000	0.998	0.002
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.000	0.998	0.002
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.998	0.002
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.000	0.998	0.002
M80-M85 Disorders of bone density and structure	0.002	0.998	0.000
M90.78 Fracture of bone in neoplastic disease (Other)	0.002	0.998	0.000
C08.0 Submandibular gland	0.000	0.998	0.002
T92.2 Sequelae of fracture at wrist and hand level	0.002	0.998	0.000
C78.0 Secondary malignant neoplasm of lung	0.002	0.998	0.000
D46.9 Myelodysplastic syndrome, unspecified	0.000	0.998	0.002
T42.5 Mixed antiepileptics, not elsewhere classified	0.000	0.998	0.002
T42.2 Succinimides and oxazolidinediones	0.000	0.998	0.002
C02 Malignant neoplasm of other and unspecified parts of tongue	0.000	0.998	0.002
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.002	0.998	0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.002	0.998	0.000
D48.5 Skin	0.000	0.998	0.002
T43.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.998	0.002
F23 Acute and transient psychotic disorders	0.000	0.998	0.002
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.000	0.998	0.002
C00.1 External lower lip	0.000	0.998	0.002
J15.0 Pneumonia due to Klebsiella pneumoniae	0.002	0.998	0.000
M85.20 Hyperostosis of skull-Mult sites	0.002	0.998	0.000
C08.9 Major salivary gland, unspecified	0.000	0.998	0.002
C08.8 Overlapping lesion of major salivary glands	0.000	0.998	0.002
C08.1 Sublingual gland	0.000	0.998	0.002
M85.65 Other cyst of bone (Pelvic region and thigh)	0.002	0.998	0.000
C04.0 Anterior floor of mouth	0.000	0.998	0.002
F23.0 Acute polymorphic psychotic disorder without symptoms of schizophrenia	0.000	0.998	0.002
T42.0 Hydantoin derivatives	0.000	0.998	0.002
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)	0.002	0.998	0.000
M80.58 Idiopathic osteoporosis with pathological fracture (Other)	0.002	0.998	0.000
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)	0.002	0.998	0.000
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)	0.002	0.998	0.000
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)	0.002	0.998	0.000
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)	0.002	0.998	0.000
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)	0.002	0.998	0.000
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)	0.002	0.998	0.000
M85.68 Other cyst of bone (Other)	0.002	0.998	0.000
K60.4 Rectal fistula	0.002	0.998	0.000
M84 Disorders of continuity of bone	0.002	0.998	0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.002	0.998	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.002	0.998	0.000
M80.89 Other osteoporosis with pathological fracture (Site unspecified)	0.002	0.998	0.000
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)	0.002	0.998	0.000
M80.86 Other osteoporosis with pathological fracture (Lower leg)	0.002	0.998	0.000
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)	0.002	0.998	0.000
M80.84 Other osteoporosis with pathological fracture (Hand)	0.002	0.998	0.000
M80.83 Other osteoporosis with pathological fracture (Forearm)	0.002	0.998	0.000
M80.82 Other osteoporosis with pathological fracture (Upper arm)	0.002	0.998	0.000
M80.80 Other osteoporosis with pathological fracture (Multiple sites)	0.002	0.998	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.002	0.998	0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.002	0.998	0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.002	0.998	0.000
M84.2 Delayed union of fracture	0.002	0.998	0.000
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances	0.000	0.998	0.002
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.002	0.998	0.000
T42.3 Barbiturates	0.000	0.998	0.002
Z35.1 Supervision of pregnancy with history of abortive outcome	0.000	0.998	0.002
C11 Malignant neoplasm of nasopharynx	0.000	0.998	0.001
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.000	0.998	0.002
Z03.1 Observation for suspected malignant neoplasm	0.002	0.998	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.000	0.998	0.002
C03.9 Gum, unspecified	0.000	0.998	0.001
C03.0 Upper gum	0.000	0.998	0.001
C04.8 Overlapping lesion of floor of mouth	0.000	0.998	0.002
C04.1 Lateral floor of mouth	0.000	0.998	0.002
K82.1 Hydrops of gallbladder	0.000	0.998	0.002
T43.9 Psychotropic drug, unspecified	0.000	0.998	0.002
M80.29 Osteoporosis of disuse with pathological fracture (Site unspecified)	0.001	0.998	0.000
M80.28 Osteoporosis of disuse with pathological fracture (Other)	0.001	0.998	0.000
M80.27 Osteoporosis of disuse with pathological fracture (Ankle and foot)	0.001	0.998	0.000
M80.26 Osteoporosis of disuse with pathological fracture (Lower leg)	0.001	0.998	0.000
M80.25 Osteoporosis of disuse with pathological fracture (Pelvic region and thigh)	0.001	0.998	0.000
M80.24 Osteoporosis of disuse with pathological fracture (Hand)	0.001	0.998	0.000
M80.23 Osteoporosis of disuse with pathological fracture (Forearm)	0.001	0.998	0.000
M80.22 Osteoporosis of disuse with pathological fracture (Upper arm)	0.001	0.998	0.000
M80.21 Osteoporosis of disuse with pathological fracture (Shoulder region)	0.001	0.998	0.000
M80.20 Osteoporosis of disuse with pathological fracture (Multiple sites)	0.001	0.998	0.000
M80.39 Postsurgical malabsorption osteoporosis with pathological fracture (Site unspecified)	0.001	0.998	0.000
M80.38 Postsurgical malabsorption osteoporosis with pathological fracture (Other)	0.001	0.998	0.000
M80.37 Postsurgical malabsorption osteoporosis with pathological fracture (Ankle and foot)	0.001	0.998	0.000
M80.36 Postsurgical malabsorption osteoporosis with pathological fracture (Lower leg)	0.001	0.998	0.000
M80.35 Postsurgical malabsorption osteoporosis with pathological fracture (Pelvic region and thigh)	0.001	0.998	0.000
M80.34 Postsurgical malabsorption osteoporosis with pathological fracture (Hand)	0.001	0.998	0.000
M80.33 Postsurgical malabsorption osteoporosis with pathological fracture (Forearm)	0.001	0.998	0.000
M80.32 Postsurgical malabsorption osteoporosis with pathological fracture (Upper arm)	0.001	0.998	0.000
M80.31 Postsurgical malabsorption osteoporosis with pathological fracture (Shoulder region)	0.001	0.998	0.000
M80.30 Postsurgical malabsorption osteoporosis with pathological fracture (Multiple sites)	0.001	0.998	0.000
M80.49 Drug-induced osteoporosis with pathological fracture (Site unspecified)	0.001	0.998	0.000
M80.48 Drug-induced osteoporosis with pathological fracture (Other)	0.001	0.998	0.000
M80.47 Drug-induced osteoporosis with pathological fracture (Ankle and foot)	0.001	0.998	0.000
M80.46 Drug-induced osteoporosis with pathological fracture (Lower leg)	0.001	0.998	0.000
M80.45 Drug-induced osteoporosis with pathological fracture (Pelvic region and thigh)	0.001	0.998	0.000
M80.44 Drug-induced osteoporosis with pathological fracture (Hand)	0.001	0.998	0.000
M80.43 Drug-induced osteoporosis with pathological fracture (Forearm)	0.001	0.998	0.000
M80.42 Drug-induced osteoporosis with pathological fracture (Upper arm)	0.001	0.998	0.000
M80.41 Drug-induced osteoporosis with pathological fracture (Shoulder region)	0.001	0.998	0.000
M80.40 Drug-induced osteoporosis with pathological fracture (Multiple sites)	0.001	0.998	0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.002	0.998	0.000
M84.21 Delayed union of fracture (Shoulder region)	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations