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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4634439
log Bayes Factor = 142.37
Chromosome 6   position 26,598,004  (GRCh37) Explore rs4634439 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
D64.9 Anaemia, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
N40 Hyperplasia of prostate
0.000 0.000 1.000
E03 Other hypothyroidism
1.000 0.000 0.000
M17 Gonarthrosis [arthrosis of knee]
1.000 0.000 0.000
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
R31 Unspecified haematuria
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
1.000 0.000 0.000
D60-D64 Aplastic and other anaemias
1.000 0.000 0.000
D64 Other anaemias
1.000 0.000 0.000
M15-M19 Arthrosis
1.000 0.000 0.000
M17.9 Gonarthrosis, unspecified
1.000 0.000 0.000
M05-M14 Inflammatory polyarthropathies
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.999 0.001 0.000
E16 Other disorders of pancreatic internal secretion
0.999 0.001 0.000
E16.2 Hypoglycaemia, unspecified
0.998 0.002 0.000
D50-D53 Nutritional anaemias
0.997 0.003 0.000
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.000 0.003 0.997
M35 Other systemic involvement of connective tissue
0.997 0.003 0.000
K40 Inguinal hernia
0.000 0.004 0.996
Chapter XII Diseases of the skin and subcutaneous tissue
0.996 0.004 0.000
D50 Iron deficiency anaemia
0.995 0.005 0.000
K90 Intestinal malabsorption
0.994 0.005 0.001
M35.0 Sicca syndrome [Sjogren]
0.995 0.005 0.000
L20-L30 Dermatitis and eczema
0.995 0.005 0.000
K44.9 Diaphragmatic hernia without obstruction or gangrene
0.000 0.006 0.994
K44 Diaphragmatic hernia
0.000 0.008 0.992
K40-K46 Hernia
0.001 0.008 0.991
L30 Other dermatitis
0.991 0.009 0.000
M31 Other necrotising vasculopathies
0.991 0.009 0.000
E20-E35 Disorders of other endocrine glands
0.990 0.010 0.000
E27 Other disorders of adrenal gland
0.989 0.011 0.000
E10.3 With ophthalmic complications
0.989 0.011 0.000
D50.9 Iron deficiency anaemia, unspecified
0.989 0.011 0.000
E27.1 Primary adrenocortical insufficiency
0.988 0.012 0.000
L30.9 Dermatitis, unspecified
0.988 0.012 0.000
H36 Retinal disorders in diseases classified elsewhere
0.988 0.012 0.000
H25-H28 Disorders of lens
0.985 0.015 0.000
K90-K93 Other diseases of the digestive system
0.949 0.015 0.036
Chapter XI Diseases of the digestive system
0.948 0.016 0.036
N32.0 Bladder-neck obstruction
0.000 0.017 0.983
M06 Other rheumatoid arthritis
0.982 0.018 0.000
M31.6 Other giant cell arteritis
0.981 0.019 0.000
N32 Other disorders of bladder
0.000 0.021 0.979
H36.0 Diabetic retinopathy
0.979 0.021 0.000
H26 Other cataract
0.977 0.023 0.000
N30-N39 Other diseases of urinary system
0.000 0.023 0.977
M17.0 Primary gonarthrosis, bilateral
0.976 0.024 0.000
E11 Non-insulin-dependent diabetes mellitus
0.975 0.025 0.000
M34 Systemic sclerosis
0.975 0.025 0.000
H26.9 Cataract, unspecified
0.974 0.026 0.000
M06.9 Rheumatoid arthritis, unspecified
0.972 0.028 0.000
M25 Other joint disorders, not elsewhere classified
0.972 0.028 0.000
N39 Other disorders of urinary system
0.000 0.028 0.972
H43-H45 Disorders of vitreous body and globe
0.971 0.029 0.000
H35 Other retinal disorders
0.968 0.032 0.000
D50.8 Other iron deficiency anaemias
0.964 0.036 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.964 0.036 0.000
E10.2 With renal complications
0.963 0.037 0.000
D80-D89 Certain disorders involving the immune mechanism
0.959 0.041 0.000
M23 Internal derangement of knee
0.957 0.043 0.000
H35.8 Other specified retinal disorders
0.957 0.043 0.000
H43 Disorders of vitreous body
0.955 0.045 0.000
H34 Retinal vascular occlusions
0.952 0.048 0.000
E11.3 With ophthalmic complications
0.951 0.049 0.000
M07 Psoriatic and enteropathic arthropathies
0.951 0.049 0.000
M25.7 Osteophyte
0.950 0.050 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.948 0.052 0.000
H53-H54 Visual disturbances and blindness
0.943 0.057 0.000
H43.1 Vitreous haemorrhage
0.943 0.057 0.000
E11.5 With peripheral circulatory complications
0.943 0.057 0.000
K70-K77 Diseases of liver
0.939 0.059 0.002
H02 Other disorders of eyelid
0.941 0.059 0.000
M10 Gout
0.940 0.060 0.000
E50-E64 Other nutritional deficiencies
0.939 0.061 0.000
K40.2 Bilateral inguinal hernia, without obstruction or gangrene
0.000 0.061 0.939
K75 Other inflammatory liver diseases
0.938 0.061 0.000
E10.1 With ketoacidosis
0.938 0.062 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.935 0.065 0.000
L28 Lichen simplex chronicus and prurigo
0.935 0.065 0.000
N39.0 Urinary tract infection, site not specified
0.000 0.066 0.934
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.934 0.066 0.000
M22 Disorders of patella
0.933 0.067 0.000
K75.4 Autoimmune hepatitis
0.932 0.068 0.000
M23.3 Other meniscus derangements
0.931 0.069 0.000
M17.1 Other primary gonarthrosis
0.926 0.074 0.000
N39.8 Other specified disorders of urinary system
0.000 0.077 0.923
H02.1 Ectropion of eyelid
0.918 0.082 0.000
M07.3 Other psoriatic arthropathies
0.916 0.084 0.000
H02.5 Other disorders affecting eyelid function
0.915 0.085 0.000
E14 Unspecified diabetes mellitus
0.913 0.087 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.913 0.087 0.000
N40-N51 Diseases of male genital organs
0.000 0.089 0.911
L10-L14 Bullous disorders
0.909 0.091 0.000
K90.9 Intestinal malabsorption, unspecified
0.909 0.091 0.000
M25.76 Osteophyte (Lower leg)
0.909 0.091 0.000
N32.8 Other specified disorders of bladder
0.000 0.098 0.902
D86 Sarcoidosis
0.901 0.099 0.000
M34.1 CR(E)ST syndrome
0.900 0.100 0.000
N39.9 Disorder of urinary system, unspecified
0.000 0.100 0.900
H02.6 Xanthelasma of eyelid
0.900 0.100 0.000
H54 Blindness and low vision
0.899 0.101 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.899 0.101 0.000
N34 Urethritis and urethral syndrome
0.000 0.103 0.897
N42 Other disorders of prostate
0.000 0.105 0.895
M18 Arthrosis of first carpometacarpal joint
0.893 0.107 0.000
M11 Other crystal arthropathies
0.889 0.111 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.888 0.112 0.000
M60-M63 Disorders of muscles
0.885 0.115 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.884 0.116 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.883 0.117 0.000
M70-M79 Other soft tissue disorders
0.882 0.118 0.000
M34.9 Systemic sclerosis, unspecified
0.878 0.122 0.000
I73 Other peripheral vascular diseases
0.875 0.125 0.000
M72 Fibroblastic disorders
0.875 0.125 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.874 0.126 0.000
I73.9 Peripheral vascular disease, unspecified
0.873 0.127 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.871 0.129 0.000
E53 Deficiency of other B group vitamins
0.871 0.129 0.000
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand
0.870 0.130 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.870 0.130 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.868 0.132 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.868 0.132 0.000
L28.0 Lichen simplex chronicus
0.866 0.134 0.000
M24 Other specific joint derangements
0.866 0.134 0.000
Chapter IX Diseases of the circulatory system
0.865 0.135 0.000
L50-L54 Urticaria and erythema
0.864 0.136 0.000
H34.2 Other retinal artery occlusions
0.864 0.136 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.864 0.136 0.000
H05 Disorders of orbit
0.863 0.137 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.863 0.137 0.000
M25.9 Joint disorder, unspecified
0.862 0.138 0.000
Q50-Q56 Congenital malformations of genital organs
0.860 0.140 0.000
N42.8 Other specified disorders of prostate
0.000 0.143 0.857
E16.0 Drug-induced hypoglycaemia without coma
0.857 0.143 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.855 0.145 0.000
K75.8 Other specified inflammatory liver diseases
0.854 0.146 0.000
Chapter II Neoplasms
0.854 0.146 0.000
D86.9 Sarcoidosis, unspecified
0.854 0.146 0.000
M25.71 Osteophyte (Shoulder region)
0.850 0.150 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.848 0.152 0.000
N36 Other disorders of urethra
0.000 0.153 0.847
N39.3 Stress incontinence
0.000 0.155 0.845
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.844 0.156 0.000
H27 Other disorders of lens
0.843 0.157 0.000
K72 Hepatic failure, not elsewhere classified
0.841 0.158 0.001
M10.0 Idiopathic gout
0.841 0.159 0.000
M22.3 Other derangements of patella
0.841 0.159 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.840 0.159 0.000
L27 Dermatitis due to substances taken internally
0.839 0.161 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.838 0.162 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.838 0.162 0.000
H26.4 After-cataract
0.837 0.163 0.000
N42.1 Congestion and haemorrhage of prostate
0.000 0.165 0.835
H31 Other disorders of choroid
0.831 0.169 0.000
E23 Hypofunction and other disorders of pituitary gland
0.831 0.169 0.000
M23.0 Cystic meniscus
0.831 0.169 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.829 0.171 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.829 0.171 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.827 0.173 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.826 0.174 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.825 0.175 0.000
M10.9 Gout, unspecified
0.825 0.175 0.000
N34.2 Other urethritis
0.000 0.176 0.824
K73 Chronic hepatitis, not elsewhere classified
0.822 0.177 0.001
E14.3 With ophthalmic complications
0.823 0.177 0.000
H46 Optic neuritis
0.823 0.177 0.000
I77 Other disorders of arteries and arterioles
0.823 0.177 0.000
S40-S49 Injuries to the shoulder and upper arm
0.822 0.178 0.000
H54.7 Unspecified visual loss
0.820 0.180 0.000
E53.8 Deficiency of other specified B group vitamins
0.820 0.180 0.000
C81 Hodgkin's disease
0.818 0.182 0.000
M23.9 Internal derangement of knee, unspecified
0.816 0.184 0.000
D55-D59 Haemolytic anaemias
0.813 0.187 0.000
M62 Other disorders of muscle
0.812 0.188 0.000
M11.2 Other chondrocalcinosis
0.809 0.191 0.000
E10.5 With peripheral circulatory complications
0.809 0.191 0.000
M14 Arthropathies in other diseases classified elsewhere
0.808 0.192 0.000
M22.8 Other disorders of patella
0.808 0.192 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.807 0.193 0.000
L30.8 Other specified dermatitis
0.803 0.197 0.000
D61 Other aplastic anaemias
0.799 0.201 0.000
L40-L45 Papulosquamous disorders
0.798 0.202 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.796 0.204 0.000
K75.9 Inflammatory liver disease, unspecified
0.795 0.205 0.000
L23 Allergic contact dermatitis
0.795 0.205 0.000
H34.8 Other retinal vascular occlusions
0.794 0.206 0.000
H26.1 Traumatic cataract
0.792 0.208 0.000
S90-S99 Injuries to the ankle and foot
0.791 0.209 0.000
C85.1 B-cell lymphoma, unspecified
0.790 0.210 0.000
M34.8 Other forms of systemic sclerosis
0.786 0.214 0.000
E10.8 With unspecified complications
0.785 0.215 0.000
L13 Other bullous disorders
0.784 0.216 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.784 0.216 0.000
C83.3 Large cell (diffuse)
0.783 0.217 0.000
S80-S89 Injuries to the knee and lower leg
0.782 0.218 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.781 0.219 0.000
E27.2 Addisonian crisis
0.781 0.219 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.780 0.220 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.780 0.220 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.001 0.220 0.779
E10.0 With coma
0.779 0.221 0.000
E31 Polyglandular dysfunction
0.777 0.223 0.000
N30 Cystitis
0.000 0.224 0.776
E10.6 With other specified complications
0.776 0.224 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.775 0.225 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.775 0.225 0.000
H33 Retinal detachments and breaks
0.774 0.226 0.000
L28.1 Prurigo nodularis
0.773 0.227 0.000
E10.4 With neurological complications
0.773 0.227 0.000
I77.1 Stricture of artery
0.771 0.229 0.000
E61 Deficiency of other nutrient elements
0.770 0.230 0.000
M00-M03 Infectious arthropathies
0.769 0.231 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.769 0.231 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.001 0.232 0.768
N48 Other disorders of penis
0.000 0.232 0.768
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.232 0.768
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.233 0.767
H35.4 Peripheral retinal degeneration
0.767 0.233 0.000
S80 Superficial injury of lower leg
0.766 0.234 0.000
L52 Erythema nodosum
0.766 0.234 0.000
N36.2 Urethral caruncle
0.000 0.235 0.765
C43-C44 Melanoma and other malignant neoplasms of skin
0.764 0.236 0.000
H05.0 Acute inflammation of orbit
0.763 0.237 0.000
Chapter XX External causes of morbidity and mortality
0.762 0.238 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.761 0.239 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.240 0.760
H54.6 Unqualified visual loss, one eye
0.758 0.242 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.758 0.242 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.758 0.242 0.000
H30 Chorioretinal inflammation
0.758 0.242 0.000
D83 Common variable immunodeficiency
0.756 0.244 0.000
T42.4 Benzodiazepines
0.000 0.244 0.756
D84 Other immunodeficiencies
0.756 0.244 0.000
M25.4 Effusion of joint
0.756 0.244 0.000
T39.1 4-Aminophenol derivatives
0.000 0.246 0.754
H43.9 Disorder of vitreous body, unspecified
0.752 0.248 0.000
M11.26 Other chondrocalcinosis (Lower leg)
0.752 0.248 0.000
M06.4 Inflammatory polyarthropathy
0.752 0.248 0.000
K35-K38 Diseases of appendix
0.738 0.249 0.014
M07.36 Other psoriatic arthropathies (Lower leg)
0.751 0.249 0.000
M10.07 Idiopathic gout (Ankle and foot)
0.748 0.252 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.746 0.253 0.000
C43 Malignant melanoma of skin
0.746 0.254 0.000
C95 Leukaemia of unspecified cell type
0.746 0.254 0.000
H43.2 Crystalline deposits in vitreous body
0.745 0.254 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.745 0.255 0.000
S46.2 Injury of muscle and tendon of other parts of biceps
0.744 0.256 0.000
E20 Hypoparathyroidism
0.744 0.256 0.000
H34.1 Central retinal artery occlusion
0.743 0.257 0.000
E13 Other specified diabetes mellitus
0.742 0.258 0.000
K44.0 Diaphragmatic hernia with obstruction, without gangrene
0.000 0.259 0.741
Chapter XIV Diseases of the genitourinary system
0.004 0.259 0.737
H35.3 Degeneration of macula and posterior pole
0.739 0.261 0.000
E14.2 Withrenal complications
0.739 0.261 0.000
H35.7 Separation of retinal layers
0.738 0.262 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.737 0.263 0.000
E11.6 With other specified complications
0.737 0.263 0.000
L12 Pemphigoid
0.736 0.263 0.000
M12 Other specific arthropathies
0.736 0.264 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.735 0.264 0.000
Q43 Other congenital malformations of intestine
0.735 0.265 0.000
C81.9 Hodgkin's disease, unspecified
0.735 0.265 0.000
T79-T79 Certain early complications of trauma
0.734 0.266 0.000
H54.4 Blindness, one eye
0.734 0.266 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.734 0.266 0.000
N32.1 Vesicointestinal fistula
0.000 0.267 0.733
M35.7 Hypermobility syndrome
0.733 0.267 0.000
K40.0 Bilateral inguinal hernia, with obstruction, without gangrene
0.000 0.267 0.732
M25.95 Joint disorder, unspecified (Pelvic region and thigh)
0.732 0.268 0.000
D80 Immunodeficiency with predominantly antibody defects
0.731 0.269 0.000
M17.5 Other secondary gonarthrosis
0.731 0.269 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.730 0.270 0.000
S80.0 Contusion of knee
0.730 0.270 0.000
W00-W19 Falls
0.730 0.270 0.000
M25.77 Osteophyte (Ankle and foot)
0.730 0.270 0.000
I77.6 Arteritis, unspecified
0.729 0.271 0.000
D53 Other nutritional anaemias
0.728 0.272 0.000
H35.0 Background retinopathy and retinal vascular changes
0.728 0.272 0.000
N30.3 Trigonitis
0.000 0.272 0.728
Q20-Q28 Congenital malformations of the circulatory system
0.727 0.273 0.000
N48.1 Balanoposthitis
0.000 0.274 0.726
M62.8 Other specified disorders of muscle
0.725 0.275 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.725 0.275 0.000
M32 Systemic lupus erythematosus
0.725 0.275 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.725 0.275 0.000
E16.1 Other hypoglycaemia
0.723 0.277 0.000
H27.0 Aphakia
0.722 0.278 0.000
M10.90 Gout, unspecified (Multiple sites)
0.722 0.278 0.000
M33 Dermatopolymyositis
0.721 0.279 0.000
M23.1 Discoid meniscus (congenital)
0.721 0.279 0.000
L11 Other acantholytic disorders
0.721 0.279 0.000
K72.0 Acute and subacute hepatic failure
0.719 0.281 0.000
H34.9 Retinal vascular occlusion, unspecified
0.719 0.281 0.000
K90.8 Other intestinal malabsorption
0.718 0.281 0.001
I73.0 Raynaud's syndrome
0.718 0.282 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.718 0.282 0.000
S49.9 Unspecified injury of shoulder and upper arm
0.717 0.283 0.000
E10.7 With multiple complications
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.717 0.283 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.717 0.283 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.717 0.283 0.000
D64.4 Congenital dyserythropoietic anaemia
0.717 0.283 0.000
D64.3 Other sideroblastic anaemias
0.717 0.283 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.717 0.283 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.717 0.283 0.000
D64.0 Hereditary sideroblastic anaemia
0.717 0.283 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.717 0.283 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.717 0.283 0.000
M08 Juvenile arthritis
0.717 0.283 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.716 0.283 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.716 0.284 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.716 0.284 0.000
E16.4 Abnormal secretion of gastrin
0.716 0.284 0.000
E16.3 Increased secretion of glucagon
0.716 0.284 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.716 0.284 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.716 0.284 0.000
H54.0 Blindness, both eyes
0.715 0.285 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.715 0.285 0.000
M35.8 Other specified systemic involvement of connective tissue
0.715 0.285 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.715 0.285 0.000
M35.5 Multifocal fibrosclerosis
0.715 0.285 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.715 0.285 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.714 0.286 0.000
E11.0 With coma
0.714 0.286 0.000
K40.4 Unilateral or unspecified inguinal hernia, with gangrene
0.000 0.286 0.714
K40.1 Bilateral inguinal hernia, with gangrene
0.000 0.286 0.714
D50.1 Sideropenic dysphagia
0.714 0.286 0.000
K90.3 Pancreatic steatorrhoea
0.713 0.286 0.001
K90.2 Blind loop syndrome, not elsewhere classified
0.713 0.286 0.001
K90.1 Tropical sprue
0.713 0.286 0.001
L24 Irritant contact dermatitis
0.713 0.287 0.000
L26 Exfoliative dermatitis
0.713 0.287 0.000
L22 Diaper [napkin] dermatitis
0.713 0.287 0.000
S93.0 Dislocation of ankle joint
0.713 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.712 0.288 0.000
C04 Malignant neoplasm of floor of mouth
0.712 0.288 0.000
K44.1 Diaphragmatic hernia with gangrene
0.000 0.288 0.711
M76 Enthesopathies of lower limb, excluding foot
0.711 0.289 0.000
L30.5 Pityriasis alba
0.711 0.289 0.000
L30.4 Erythema intertrigo
0.711 0.289 0.000
L30.3 Infective dermatitis
0.711 0.289 0.000
L30.2 Cutaneous autosensitisation
0.711 0.289 0.000
L30.1 Dyshidrosis [pompholyx]
0.711 0.289 0.000
L30.0 Nummular dermatitis
0.711 0.289 0.000
M31.9 Necrotising vasculopathy, unspecified
0.710 0.290 0.000
M31.8 Other specified necrotising vasculopathies
0.710 0.290 0.000
M31.7 Microscopic polyangiitis
0.710 0.290 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.710 0.290 0.000
M31.2 Lethal midline granuloma
0.710 0.290 0.000
M31.1 Thrombotic microangiopathy
0.710 0.290 0.000
M31.0 Hypersensitivity angiitis
0.710 0.290 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.710 0.290 0.000
E32 Diseases of thymus
0.710 0.290 0.000
E30 Disorders of puberty, not elsewhere classified
0.710 0.290 0.000
E25 Adrenogenital disorders
0.710 0.290 0.000
E27.5 Adrenomedullary hyperfunction
0.709 0.291 0.000
E27.0 Other adrenocortical overactivity
0.709 0.291 0.000
M35.2 Behcet's disease
0.708 0.292 0.000
M25.97 Joint disorder, unspecified (Ankle and foot)
0.708 0.292 0.000
E05.8 Other thyrotoxicosis
0.708 0.292 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.708 0.292 0.000
H47.2 Optic atrophy
0.708 0.292 0.000
M22.0 Recurrent dislocation of patella
0.708 0.292 0.000
Q50.4 Embryonic cyst of Fallopian tube
0.707 0.293 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.706 0.294 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.680 0.294 0.026
H01 Other inflammation of eyelid
0.705 0.295 0.000
Q39 Congenital malformations of oesophagus
0.705 0.295 0.000
M06.8 Other specified rheumatoid arthritis
0.704 0.296 0.000
M06.2 Rheumatoid bursitis
0.704 0.296 0.000
M06.1 Adult-onset Still's disease
0.704 0.296 0.000
K72.9 Hepatic failure, unspecified
0.703 0.297 0.000
S93.1 Dislocation of toe(s)
0.703 0.297 0.000
H02.0 Entropion and trichiasis of eyelid
0.703 0.297 0.000
H43.8 Other disorders of vitreous body
0.703 0.297 0.000
H33.4 Traction detachment of retina
0.703 0.297 0.000
N32.4 Rupture of bladder, nontraumatic
0.000 0.298 0.702
N32.2 Vesical fistula, not elsewhere classified
0.000 0.298 0.702
M23.06 Cystic meniscus (Other and unspecified lateral meniscus)
0.702 0.298 0.000
L27.1 Localised skin eruption due to drugs and medicaments
0.702 0.298 0.000
M24.1 Other articular cartilage disorders
0.701 0.299 0.000
H26.3 Drug-induced cataract
0.701 0.299 0.000
N37 Urethral disorders in diseases classified elsewhere
0.000 0.299 0.700
N33 Bladder disorders in diseases classified elsewhere
0.000 0.299 0.700
D62 Acute posthaemorrhagic anaemia
0.700 0.300 0.000
M10.94 Gout, unspecified (Hand)
0.700 0.300 0.000
K40.3 Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
0.000 0.300 0.700
H35.2 Other proliferative retinopathy
0.699 0.301 0.000
M23.4 Loose body in knee
0.699 0.301 0.000
E11.7 With multiple complications
0.699 0.301 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.699 0.301 0.000
M34.0 Progressive systemic sclerosis
0.699 0.301 0.000
M35.1 Other overlap syndromes
0.698 0.302 0.000
N34.3 Urethral syndrome, unspecified
0.000 0.302 0.698
S20-S29 Injuries to the thorax
0.698 0.302 0.000
M65-M68 Disorders of synovium and tendon
0.697 0.303 0.000
M25.2 Flail joint
0.697 0.303 0.000
M25.1 Fistula of joint
0.697 0.303 0.000
N39.2 Orthostatic proteinuria, unspecified
0.000 0.303 0.697
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.696 0.304 0.000
H53 Visual disturbances
0.696 0.304 0.000
H31.8 Other specified disorders of choroid
0.695 0.305 0.000
S80.8 Other superficial injuries of lower leg
0.695 0.305 0.000
Q53 Undescended testicle
0.695 0.305 0.000
N36.3 Prolapsed urethral mucosa
0.000 0.305 0.695
L13.0 Dermatitis herpetiformis
0.694 0.306 0.000
H35.1 Retinopathy of prematurity
0.694 0.306 0.000
E11.9 Without complications
0.694 0.306 0.000
M23.99 Internal derangement of knee, unspecified (Unspecified ligament or Unspecified meniscus)
0.693 0.307 0.000
N41 Inflammatory diseases of prostate
0.000 0.307 0.693
K46 Unspecified abdominal hernia
0.001 0.308 0.691
D51 Vitamin B12 deficiency anaemia
0.692 0.308 0.000
M35.3 Polymyalgia rheumatica
0.691 0.309 0.000
M91-M94 Chondropathies
0.691 0.309 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.689 0.311 0.000
M86-M90 Other osteopathies
0.688 0.312 0.000
K35 Acute appendicitis
0.687 0.313 0.001
D82 Immunodeficiency associated with other major defects
0.687 0.313 0.000
D81 Combined immunodeficiencies
0.687 0.313 0.000
H26.2 Complicated cataract
0.686 0.313 0.000
L21 Seborrhoeic dermatitis
0.685 0.314 0.000
Q51 Congenital malformations of uterus and cervix
0.685 0.315 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.685 0.315 0.000
H43.0 Vitreous prolapse
0.685 0.315 0.000
H05.8 Other disorders of orbit
0.684 0.315 0.000
C83.0 Small cell (diffuse)
0.684 0.316 0.000
H34.0 Transient retinal artery occlusion
0.682 0.318 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.682 0.318 0.000
E03.8 Other specified hypothyroidism
0.682 0.318 0.000
M07.6 Other enteropathic arthropathies
0.682 0.318 0.000
M07.5 Arthropathy in ulcerative colitis
0.682 0.318 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.682 0.318 0.000
M07.2 Psoriatic spondylitis
0.682 0.318 0.000
M07.1 Arthritis mutilans
0.682 0.318 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.682 0.318 0.000
M25.79 Osteophyte (Site unspecified)
0.681 0.319 0.000
M25.73 Osteophyte (Forearm)
0.681 0.319 0.000
M25.70 Osteophyte (Multiple sites)
0.681 0.319 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.681 0.319 0.000
E11.1 With ketoacidosis
0.681 0.319 0.000
D86.8 Sarcoidosis of other and combined sites
0.681 0.319 0.000
M25.0 Haemarthrosis
0.681 0.319 0.000
M06.3 Rheumatoid nodule
0.679 0.321 0.000
E23.6 Other disorders of pituitary gland
0.678 0.322 0.000
N48.4 Impotence of organic origin
0.000 0.323 0.677
T39.0 Salicylates
0.000 0.324 0.676
T00-T07 Injuries involving multiple body regions
0.676 0.324 0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.675 0.325 0.000
L50 Urticaria
0.675 0.325 0.000
Q45 Other congenital malformations of digestive system
0.675 0.325 0.000
L25 Unspecified contact dermatitis
0.675 0.325 0.000
K77 Liver disorders in diseases classified elsewhere
0.673 0.325 0.001
K71 Toxic liver disease
0.673 0.325 0.001
M24.8 Other specific joint derangements, not elsewhere classified
0.675 0.325 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.675 0.325 0.000
H53.1 Subjective visual disturbances
0.674 0.326 0.000
M10.4 Other secondary gout
0.674 0.326 0.000
M10.3 Gout due to impairment of renal function
0.674 0.326 0.000
M10.2 Drug-induced gout
0.674 0.326 0.000
M10.1 Lead-induced gout
0.674 0.326 0.000
H47.3 Other disorders of optic disk
0.674 0.326 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.673 0.327 0.000
E63 Other nutritional deficiencies
0.673 0.327 0.000
E56 Other vitamin deficiencies
0.673 0.327 0.000
E51 Thiamine deficiency
0.673 0.327 0.000
E50 Vitamin A deficiency
0.673 0.327 0.000
E60 Dietary zinc deficiency
0.673 0.327 0.000
E59 Dietary selenium deficiency
0.673 0.327 0.000
E58 Dietary calcium deficiency
0.673 0.327 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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