TreeWAS – Variant ID: rs4656682

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
D68.2 Hereditary deficiency of other clotting factors	1.000	0.000	0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	1.000	0.000	0.000
Z86.7 Personal history of diseases of the circulatory system	1.000	0.000	0.000
I80 Phlebitis and thrombophlebitis	1.000	0.000	0.000
D68 Other coagulation defects	1.000	0.000	0.000
D68.5 Primary Thrombophilia	1.000	0.000	0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.997	0.003	0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.995	0.005	0.000
D68.8 Other specified coagulation defects	0.977	0.023	0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.932	0.068	0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.928	0.072	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.913	0.087	0.000
I26 Pulmonary embolism	0.904	0.096	0.000
I82 Other venous embolism and thrombosis	0.899	0.101	0.000
I82.9 Embolism and thrombosis of unspecified vein	0.850	0.150	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.849	0.151	0.000
I82.8 Embolism and thrombosis of other specified veins	0.847	0.153	0.000
Chapter IX Diseases of the circulatory system	0.820	0.180	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.813	0.187	0.000
D68.9 Coagulation defect, unspecified	0.808	0.192	0.000
I87 Other disorders of veins	0.803	0.197	0.000
I88 Nonspecific lymphadenitis	0.761	0.239	0.000
I80.8 Phlebitis and thrombophlebitis of other sites	0.749	0.251	0.000
I87.2 Venous insufficiency (chronic) (peripheral)	0.749	0.251	0.000
D68.4 Acquired coagulation factor deficiency	0.717	0.283	0.000
D68.6 Other Thrombophilia	0.709	0.291	0.000
D68.1 Hereditary factor XI deficiency	0.689	0.311	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.678	0.322	0.000
I85 Oesophageal varices	0.665	0.335	0.000
I86 Varicose veins of other sites	0.656	0.344	0.000
I82.3 Embolism and thrombosis of renal vein	0.644	0.356	0.000
I82.1 Thrombophlebitis migrans	0.644	0.356	0.000
I82.0 Budd-Chiari syndrome	0.644	0.356	0.000
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.643	0.357	0.000
I71 Aortic aneurysm and dissection	0.635	0.365	0.000
I82.2 Embolism and thrombosis of vena cava	0.629	0.371	0.000
I88.0 Nonspecific mesenteric lymphadenitis	0.613	0.387	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.605	0.395	0.000
I88.9 Nonspecific lymphadenitis, unspecified	0.602	0.398	0.000
I00-I02 Acute rheumatic fever	0.588	0.412	0.000
I28 Other diseases of pulmonary vessels	0.580	0.420	0.000
I87.9 Disorder of vein, unspecified	0.575	0.424	0.000
I87.0 Postphlebitic syndrome	0.575	0.424	0.000
I60-I69 Cerebrovascular diseases	0.574	0.426	0.000
I72 Other aneurysm	0.568	0.432	0.000
I27 Other pulmonary heart diseases	0.563	0.437	0.000
I85.0 Oesophageal varices with bleeding	0.562	0.438	0.000
I60 Subarachnoid haemorrhage	0.549	0.451	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.549	0.451	0.000
I88.8 Other nonspecific lymphadenitis	0.546	0.454	0.000
I88.1 Chronic lymphadenitis, except mesenteric	0.546	0.454	0.000
I87.8 Other specified disorders of veins	0.542	0.458	0.000
I86.8 Varicose veins of other specified sites	0.528	0.472	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.528	0.472	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.521	0.479	0.000
I71.0 Dissection of aorta [any part]	0.517	0.483	0.000
I87.1 Compression of vein	0.513	0.487	0.000
I69 Sequelae of cerebrovascular disease	0.504	0.496	0.000
I72.8 Aneurysm of other specified arteries	0.502	0.498	0.000
I70 Atherosclerosis	0.501	0.499	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.490	0.510	0.000
I77 Other disorders of arteries and arterioles	0.488	0.512	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.483	0.517	0.000
I86.2 Pelvic varices	0.479	0.521	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.474	0.526	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.471	0.529	0.000
I86.3 Vulval varices	0.470	0.530	0.000
I86.0 Sublingual varices	0.470	0.530	0.000
I72.3 Aneurysm of iliac artery	0.465	0.535	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.455	0.545	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.455	0.545	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.455	0.545	0.000
I60.8 Other subarachnoid haemorrhage	0.454	0.546	0.000
I74 Arterial embolism and thrombosis	0.454	0.546	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.450	0.549	0.000
I86.4 Gastric varices	0.450	0.550	0.000
I81 Portal vein thrombosis	0.448	0.552	0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.448	0.552	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.447	0.553	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.446	0.554	0.000
I27.8 Other specified pulmonary heart diseases	0.443	0.557	0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.431	0.568	0.000
D68.0 Von Willebrand's disease	0.430	0.570	0.001
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.429	0.571	0.000
I02 Rheumatic chorea	0.421	0.578	0.000
I01 Rheumatic fever with heart involvement	0.421	0.578	0.000
I00 Rheumatic fever without mention of heart involvement	0.421	0.578	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.419	0.581	0.000
I28.9 Disease of pulmonary vessels, unspecified	0.416	0.584	0.000
I28.1 Aneurysm of pulmonary artery	0.416	0.584	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.416	0.584	0.000
I27.9 Pulmonary heart disease, unspecified	0.415	0.585	0.000
I05-I09 Chronic rheumatic heart diseases	0.413	0.587	0.000
I72.6 Aneurysm and dissection of vertebral artery	0.407	0.593	0.000
I72.5 Aneurysm and dissection of other precerebral arteries	0.407	0.593	0.000
I72.1 Aneurysm of artery of upper extremity	0.407	0.593	0.000
I27.1 Kyphoscoliotic heart disease	0.404	0.596	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.403	0.597	0.000
I86.1 Scrotal varices	0.402	0.598	0.000
I72.9 Aneurysm of unspecified site	0.401	0.599	0.000
I61 Intracerebral haemorrhage	0.401	0.599	0.000
I77.1 Stricture of artery	0.399	0.601	0.000
I60.5 Subarachnoid haemorrhage from vertebral artery	0.394	0.606	0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.394	0.606	0.000
I77.2 Rupture of artery	0.393	0.607	0.000
I70.0 Atherosclerosis of aorta	0.391	0.609	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.391	0.609	0.000
I72.0 Aneurysm of carotid artery	0.389	0.610	0.000
I28.8 Other specified diseases of pulmonary vessels	0.388	0.612	0.000
I65.2 Occlusion and stenosis of carotid artery	0.386	0.614	0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.386	0.614	0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.383	0.617	0.000
I60.4 Subarachnoid haemorrhage from basilar artery	0.380	0.620	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.371	0.628	0.000
I27.2 Other secondary pulmonary hypertension	0.367	0.633	0.000
I72.2 Aneurysm of renal artery	0.364	0.636	0.000
I73 Other peripheral vascular diseases	0.363	0.637	0.000
I72.4 Aneurysm of artery of lower extremity	0.363	0.637	0.000
I70.9 Generalised and unspecified atherosclerosis	0.359	0.641	0.000
I70.8 Atherosclerosis of other arteries	0.359	0.641	0.000
I77.0 Arteriovenous fistula, acquired	0.356	0.644	0.000
I68.0 Cerebral amyloid angiopathy	0.356	0.644	0.000
I70.1 Atherosclerosis of renal artery	0.356	0.644	0.000
I77.5 Necrosis of artery	0.350	0.650	0.000
I77.4 Coeliac artery compression syndrome	0.350	0.650	0.000
I77.3 Arterial fibromuscular dysplasia	0.350	0.650	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.349	0.650	0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.347	0.653	0.000
I79.1 Aortitis in diseases classified elsewhere	0.347	0.653	0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.347	0.653	0.000
I74.8 Embolism and thrombosis of other arteries	0.346	0.654	0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.344	0.656	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.343	0.657	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.341	0.659	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.341	0.659	0.000
D66 Hereditary factor VIII deficiency	0.338	0.662	0.000
I85.9 Oesophageal varices without bleeding	0.338	0.662	0.000
I77.8 Other specified disorders of arteries and arterioles	0.337	0.663	0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery	0.331	0.669	0.000
I74.5 Embolism and thrombosis of iliac artery	0.330	0.669	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.330	0.670	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.326	0.674	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.326	0.674	0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery	0.325	0.675	0.000
I77.9 Disorder of arteries and arterioles, unspecified	0.325	0.675	0.000
I27.0 Primary pulmonary hypertension	0.324	0.676	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.323	0.677	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.323	0.677	0.000
I65.1 Occlusion and stenosis of basilar artery	0.323	0.677	0.000
I61.8 Other intracerebral haemorrhage	0.321	0.679	0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere	0.321	0.679	0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere	0.321	0.679	0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere	0.321	0.679	0.000
D67 Hereditary factor IX deficiency	0.320	0.680	0.000
I61.6 Intracerebral haemorrhage, multiple localised	0.320	0.680	0.000
I06 Rheumatic aortic valve diseases	0.317	0.683	0.000
I70.00 Atherosclerosis of aorta (without gangrene)	0.313	0.687	0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.311	0.688	0.000
I66.8 Occlusion and stenosis of other cerebral artery	0.308	0.692	0.000
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries	0.308	0.692	0.000
I66.3 Occlusion and stenosis of cerebellar arteries	0.308	0.692	0.000
I66.2 Occlusion and stenosis of posterior cerebral artery	0.308	0.692	0.000
I66.1 Occlusion and stenosis of anterior cerebral artery	0.308	0.692	0.000
I66.0 Occlusion and stenosis of middle cerebral artery	0.308	0.692	0.000
I01.9 Acute rheumatic heart disease, unspecified	0.302	0.698	0.000
I01.8 Other acute rheumatic heart disease	0.302	0.698	0.000
I01.2 Acute rheumatic myocarditis	0.302	0.698	0.000
I01.1 Acute rheumatic endocarditis	0.302	0.698	0.000
I01.0 Acute rheumatic pericarditis	0.302	0.698	0.000
I02.9 Rheumatic chorea without heart involvement	0.302	0.698	0.000
I02.0 Rheumatic chorea with heart involvement	0.302	0.698	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.301	0.699	0.000
I61.4 Intracerebral haemorrhage in cerebellum	0.300	0.700	0.000
I07 Rheumatic tricuspid valve diseases	0.297	0.703	0.000
I09 Other rheumatic heart diseases	0.296	0.704	0.000
I74.0 Embolism and thrombosis of abdominal aorta	0.290	0.710	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.289	0.710	0.000
I73.1 Thromboangiitis obliterans [Buerger]	0.288	0.712	0.000
I70.01 Atherosclerosis of aorta (with gangrene)	0.281	0.719	0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.276	0.723	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.273	0.727	0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical	0.270	0.730	0.000
I05 Rheumatic mitral valve diseases	0.258	0.742	0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.258	0.742	0.000
I70.81 Atherosclerosis of other arteries (with gangrene)	0.258	0.742	0.000
I70.80 Atherosclerosis of other arteries (without gangrene)	0.258	0.742	0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)	0.258	0.742	0.000
I70.90 Generalized and unspecified atherosclerosis (without gangrene)	0.258	0.742	0.000
I70.11 Atherosclerosis of renal artery (with gangrene)	0.255	0.745	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.253	0.747	0.000
I70.10 Atherosclerosis of renal artery (without gangrene)	0.252	0.748	0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified	0.248	0.752	0.000
I06.0 Rheumatic aortic stenosis	0.248	0.752	0.000
I77.6 Arteritis, unspecified	0.244	0.756	0.000
I78 Diseases of capillaries	0.243	0.757	0.000
I73.9 Peripheral vascular disease, unspecified	0.242	0.758	0.000
I62 Other nontraumatic intracranial haemorrhage	0.237	0.763	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.233	0.767	0.001
D69 Purpura and other haemorrhagic conditions	0.233	0.767	0.000
I73.8 Other specified peripheral vascular diseases	0.231	0.769	0.000
I06.9 Rheumatic aortic valve disease, unspecified	0.227	0.773	0.000
I06.8 Other rheumatic aortic valve diseases	0.227	0.773	0.000
I06.2 Rheumatic aortic stenosis with insufficiency	0.227	0.773	0.000
I06.1 Rheumatic aortic insufficiency	0.227	0.773	0.000
I69.3 Sequelae of cerebral infarction	0.223	0.776	0.000
I05.9 Mitral valve disease, unspecified	0.221	0.779	0.000
I61.5 Intracerebral haemorrhage, intraventricular	0.216	0.784	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.215	0.785	0.000
I07.1 Tricuspid insufficiency	0.215	0.785	0.000
I07.9 Tricuspid valve disease, unspecified	0.213	0.787	0.000
I07.8 Other tricuspid valve diseases	0.213	0.787	0.000
I07.2 Tricuspid stenosis with insufficiency	0.213	0.787	0.000
I07.0 Tricuspid stenosis	0.213	0.787	0.000
I09.9 Rheumatic heart disease, unspecified	0.212	0.787	0.000
I09.8 Other specified rheumatic heart diseases	0.212	0.787	0.000
I09.2 Chronic rheumatic pericarditis	0.212	0.787	0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified	0.212	0.787	0.000
I09.0 Rheumatic myocarditis	0.212	0.787	0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.209	0.791	0.000
I99 Other and unspecified disorders of circulatory system	0.209	0.791	0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)	0.208	0.792	0.000
D69.5 Secondary thrombocytopenia	0.201	0.799	0.000
I05.8 Other mitral valve diseases	0.185	0.815	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.182	0.818	0.000
D69.2 Other nonthrombocytopenic purpura	0.182	0.818	0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.177	0.823	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.176	0.824	0.000
I78.9 Disease of capillaries, unspecified	0.174	0.825	0.000
I05.2 Mitral stenosis with insufficiency	0.172	0.828	0.000
I83 Varicose veins of lower extremities	0.171	0.829	0.000
I62.1 Nontraumatic extradural haemorrhage	0.170	0.830	0.000
I78.8 Other diseases of capillaries	0.170	0.830	0.000
D69.8 Other specified haemorrhagic conditions	0.167	0.833	0.000
D69.1 Qualitative platelet defects	0.167	0.833	0.000
I10-I15 Hypertensive diseases	0.167	0.833	0.000
D69.0 Allergic purpura	0.166	0.834	0.000
I73.0 Raynaud's syndrome	0.162	0.838	0.000
D69.4 Other primary thrombocytopenia	0.161	0.839	0.000
I97.9 Postprocedural disorder of circulatory system, unspecified	0.150	0.850	0.000
I97.0 Postcardiotomy syndrome	0.150	0.850	0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified	0.149	0.850	0.001
I30-I52 Other forms of heart disease	0.149	0.851	0.000
I05.1 Rheumatic mitral insufficiency	0.147	0.853	0.000
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes	0.145	0.854	0.001
D69.9 Haemorrhagic condition, unspecified	0.144	0.856	0.000
I35 Nonrheumatic aortic valve disorders	0.144	0.856	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.144	0.856	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.142	0.858	0.000
I08 Multiple valve diseases	0.142	0.858	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.141	0.859	0.000
I05.0 Mitral stenosis	0.138	0.862	0.000
I30 Acute pericarditis	0.133	0.867	0.000
I31 Other diseases of pericardium	0.132	0.868	0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified	0.131	0.868	0.001
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.130	0.869	0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.130	0.869	0.000
I98.0 Cardiovascular syphilis	0.130	0.869	0.000
I33 Acute and subacute endocarditis	0.131	0.869	0.000
I97.1 Other functional disturbances following cardiac surgery	0.129	0.871	0.000
I11 Hypertensive heart disease	0.129	0.871	0.000
I36 Nonrheumatic tricuspid valve disorders	0.128	0.872	0.000
I35.9 Aortic valve disorder, unspecified	0.124	0.876	0.000
I08.8 Other multiple valve diseases	0.123	0.877	0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.121	0.878	0.000
I89.1 Lymphangitis	0.121	0.878	0.001
I78.0 Hereditary haemorrhagic telangiectasia	0.120	0.879	0.001
I97.2 Postmastectomy lymphoedema syndrome	0.120	0.880	0.000
I13 Hypertensive heart and renal disease	0.120	0.880	0.000
I30.9 Acute pericarditis, unspecified	0.117	0.883	0.000
I31.3 Pericardial effusion (noninflammatory)	0.116	0.884	0.000
I33.0 Acute and subacute infective endocarditis	0.113	0.887	0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.113	0.887	0.000
I35.1 Aortic (valve) insufficiency	0.110	0.890	0.000
I46 Cardiac arrest	0.108	0.892	0.000
I30.1 Infective pericarditis	0.108	0.892	0.000
I35.8 Other aortic valve disorders	0.107	0.893	0.000
I40 Acute myocarditis	0.107	0.893	0.000
I52 Other heart disorders in diseases classified elsewhere	0.107	0.893	0.000
I48 Atrial fibrillation and flutter	0.107	0.893	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.107	0.893	0.000
I41 Myocarditis in diseases classified elsewhere	0.107	0.893	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.107	0.893	0.000
I32 Pericarditis in diseases classified elsewhere	0.107	0.893	0.000
I31.1 Chronic constrictive pericarditis	0.106	0.894	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.106	0.894	0.000
I15 Secondary hypertension	0.105	0.895	0.000
I63 Cerebral infarction	0.105	0.895	0.000
I37 Pulmonary valve disorders	0.105	0.895	0.000
I33.9 Acute endocarditis, unspecified	0.102	0.898	0.000
I08.9 Multiple valve disease, unspecified	0.102	0.898	0.000
I83.1 Varicose veins of lower extremities with inflammation	0.101	0.899	0.000
I45 Other conduction disorders	0.098	0.902	0.000
I31.9 Disease of pericardium, unspecified	0.096	0.904	0.000
I30.8 Other forms of acute pericarditis	0.096	0.904	0.000
I30.0 Acute nonspecific idiopathic pericarditis	0.096	0.904	0.000
I31.8 Other specified diseases of pericardium	0.095	0.905	0.000
I31.2 Haemopericardium, not elsewhere classified	0.095	0.905	0.000
I31.0 Chronic adhesive pericarditis	0.093	0.907	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.092	0.907	0.000
I36.9 Nonrheumatic tricuspid valve disorder, unspecified	0.092	0.908	0.000
I36.8 Other nonrheumatic tricuspid valve disorders	0.092	0.908	0.000
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency	0.092	0.908	0.000
I36.0 Nonrheumatic tricuspid (valve) stenosis	0.092	0.908	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.090	0.910	0.000
I45.5 Other specified heart block	0.088	0.912	0.000
D80-D89 Certain disorders involving the immune mechanism	0.088	0.912	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.087	0.913	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.086	0.914	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.086	0.914	0.000
I13.1 Hypertensive heart and renal disease with renal failure	0.086	0.914	0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.086	0.914	0.000
I08.0 Disorders of both mitral and aortic valves	0.086	0.914	0.000
I15.9 Seconday hypertension, unspecified	0.084	0.916	0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)	0.083	0.917	0.001
I63.8 Other cerebral infarction	0.083	0.917	0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.081	0.919	0.000
I46.9 Cardiac arrest, unspecified	0.080	0.920	0.000
D86 Sarcoidosis	0.080	0.920	0.000
I78.1 Naevus, nonneoplastic	0.080	0.920	0.000
I38 Endocarditis, valve unspecified	0.079	0.921	0.000
I45.8 Other specified conduction disorders	0.078	0.922	0.000
I46.1 Sudden cardiac death, so described	0.077	0.922	0.000
I40.0 Infective myocarditis	0.077	0.923	0.000
I40.9 Acute myocarditis, unspecified	0.077	0.923	0.000
I40.8 Other acute myocarditis	0.077	0.923	0.000
I40.1 Isolated myocarditis	0.077	0.923	0.000
I32.8 Pericarditis in other diseases classified elsewhere	0.077	0.923	0.000
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere	0.077	0.923	0.000
I32.0 Pericarditis in bacterial diseases classified elsewhere	0.077	0.923	0.000
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere	0.077	0.923	0.000
I39.4 Multiple valve disorders in diseases classified elsewhere	0.077	0.923	0.000
I39.3 Pulmonary valve disorders in diseases classified elsewhere	0.077	0.923	0.000
I39.2 Tricuspid valve disorders in diseases classified elsewhere	0.077	0.923	0.000
I39.1 Aortic valve disorders in diseases classified elsewhere	0.077	0.923	0.000
I39.0 Mitral valve disorders in diseases classified elsewhere	0.077	0.923	0.000
I41.8 Myocarditis in other diseases classified elsewhere	0.077	0.923	0.000
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere	0.077	0.923	0.000
I41.1 Myocarditis in viral diseases classified elsewhere	0.077	0.923	0.000
I41.0 Myocarditis in bacterial diseases classified elsewhere	0.077	0.923	0.000
I43.8 Cardiomyopathy in other diseases classified elsewhere	0.077	0.923	0.000
I43.2 Cardiomyopathy in nutritional diseases	0.077	0.923	0.000
I43.1 Cardiomyopathy in metabolic diseases	0.077	0.923	0.000
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere	0.077	0.923	0.000
I48.9 Atrial fibrillation and atrial flutter, unspecified	0.077	0.923	0.000
I48.4 Atypical atrial flutter	0.077	0.923	0.000
I48.3 Typical atrial flutter	0.077	0.923	0.000
I48.2 Chronic atrial fibrillation	0.077	0.923	0.000
I48.1 Persistent atrial fibrillation	0.077	0.923	0.000
I48.0 Paroxysmal atrial fibrillation	0.077	0.923	0.000
I52.8 Other heart disorders in other diseases classified elsewhere	0.077	0.923	0.000
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere	0.077	0.923	0.000
I52.0 Other heart disorders in bacterial diseases classified elsewhere	0.077	0.923	0.000
I45.3 Trifascicular block	0.077	0.923	0.000
I15.8 Other secondary hypertension	0.075	0.924	0.000
I15.2 Hypertension secondary to endocrine disorders	0.075	0.924	0.000
I15.0 Renovascular hypertension	0.075	0.924	0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.075	0.924	0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.075	0.924	0.000
I37.9 Pulmonary valve disorder, unspecified	0.075	0.924	0.000
I37.8 Other pulmonary valve disorders	0.075	0.924	0.000
I37.2 Pulmonary valve stenosis with insufficiency	0.075	0.924	0.000
I37.0 Pulmonary valve stenosis	0.075	0.924	0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.075	0.925	0.000
D80 Immunodeficiency with predominantly antibody defects	0.075	0.925	0.000
I46.0 Cardiac arrest with successful resuscitation	0.075	0.925	0.000
I95 Hypotension	0.074	0.926	0.000
I37.1 Pulmonary valve insufficiency	0.073	0.927	0.000
I45.1 Other and unspecified right bundle-branch block	0.072	0.928	0.000
D83 Common variable immunodeficiency	0.071	0.929	0.000
I45.0 Right fascicular block	0.071	0.929	0.000
D86.8 Sarcoidosis of other and combined sites	0.070	0.930	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.069	0.931	0.001
D86.9 Sarcoidosis, unspecified	0.068	0.932	0.000
D82 Immunodeficiency associated with other major defects	0.067	0.933	0.000
D84 Other immunodeficiencies	0.067	0.933	0.000
I98.2 Oesophageal varices in diseases classified elsewhere	0.066	0.933	0.000
I45.9 Conduction disorder, unspecified	0.065	0.934	0.000
I67 Other cerebrovascular diseases	0.065	0.935	0.000
D81 Combined immunodeficiencies	0.063	0.937	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.063	0.937	0.000
D86.3 Sarcoidosis of skin	0.062	0.938	0.000
I89.0 Lymphoedema, not elsewhere classified	0.061	0.938	0.001
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.061	0.939	0.000
D83.9 Common variable immunodeficiency, unspecified	0.059	0.940	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.059	0.941	0.000
I45.4 Nonspecific intraventricular block	0.058	0.942	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.058	0.942	0.000
D86.1 Sarcoidosis of lymph nodes	0.058	0.942	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.057	0.943	0.000
I95.0 Idiopathic hypotension	0.056	0.944	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.055	0.945	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.054	0.946	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.054	0.946	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.054	0.946	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.054	0.946	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.054	0.946	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.054	0.946	0.000
D86.0 Sarcoidosis of lung	0.054	0.946	0.000
D82.1 Di George's syndrome	0.053	0.947	0.000
D84.9 Immunodeficiency, unspecified	0.052	0.948	0.000
D55-D59 Haemolytic anaemias	0.052	0.948	0.000
D83.8 Other common variable immunodeficiencies	0.051	0.949	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.051	0.949	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.051	0.949	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.051	0.949	0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.050	0.949	0.000
I34 Nonrheumatic mitral valve disorders	0.050	0.950	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.048	0.951	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.048	0.951	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.048	0.951	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.048	0.951	0.000
D82.2 Immunodeficiency with short-limbed stature	0.048	0.951	0.000
D82.0 Wiskott-Aldrich syndrome	0.048	0.951	0.000
D84.8 Other specified immunodeficiencies	0.048	0.952	0.000
D84.1 Defects in the complement system	0.048	0.952	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.048	0.952	0.000
I47 Paroxysmal tachycardia	0.048	0.952	0.000
I45.2 Bifascicular block	0.048	0.952	0.000
I45.6 Preexcitation syndrome	0.048	0.952	0.000
I44 Atrioventricular and left bundle-branch block	0.048	0.952	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.047	0.953	0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.047	0.953	0.000
I67.7 Cerebral arteritis, not elsewhere classified	0.047	0.953	0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.047	0.953	0.000
I67.5 Moyamoya disease	0.047	0.953	0.000
I67.4 Hypertensive encephalopathy	0.047	0.953	0.000
I67.3 Progressive vascular leukoencephalopathy	0.047	0.953	0.000
I95.8 Other hypotension	0.046	0.954	0.000
D81.9 Combined immunodeficiency, unspecified	0.045	0.954	0.000
D81.8 Other combined immunodeficiencies	0.045	0.954	0.000
D81.7 Major histocompatibility complex class II deficiency	0.045	0.954	0.000
D81.6 Major histocompatibility complex class I deficiency	0.045	0.954	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.045	0.954	0.000
D81.4 Nezelof's syndrome	0.045	0.954	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.045	0.954	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.045	0.954	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.045	0.954	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.045	0.954	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.044	0.955	0.000
I67.0 Dissection of cerebral arteries, nonruptured	0.043	0.957	0.000
I44.2 Atrioventricular block, complete	0.043	0.957	0.000
I15.1 Hypertension secondary to other renal disorders	0.042	0.957	0.001
I50 Heart failure	0.043	0.957	0.000
D89.1 Cryoglobulinaemia	0.042	0.958	0.000
I95.1 Orthostatic hypotension	0.042	0.958	0.000
I12 Hypertensive renal disease	0.041	0.959	0.000
D56 Thalassaemia	0.041	0.959	0.000
I63.9 Cerebral infarction, unspecified	0.040	0.960	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.040	0.960	0.000
D89.3 Immune reconstitution syndrome	0.040	0.960	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.040	0.960	0.000
D69.6 Thrombocytopenia, unspecified	0.039	0.961	0.000
J18.9 Pneumonia, unspecified	0.038	0.962	0.000
I67.9 Cerebrovascular disease, unspecified	0.038	0.962	0.000
D57 Sickle-cell disorders	0.037	0.962	0.000
D55 Anaemia due to enzyme disorders	0.037	0.962	0.000
I47.0 Reentry ventricular arrhythmia	0.037	0.963	0.000
D17.2 Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs	0.037	0.963	0.000
I95.2 Hypotension due to drugs	0.037	0.963	0.000
J09-J18 Influenza and pneumonia	0.037	0.963	0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.037	0.963	0.000
J18 Pneumonia, organism unspecified	0.036	0.964	0.000
I34.8 Other nonrheumatic mitral valve disorders	0.036	0.964	0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.036	0.964	0.000
J38.3 Other diseases of vocal cords	0.035	0.965	0.000
J38.4 Oedema of larynx	0.035	0.965	0.000
Chapter X Diseases of the respiratory system	0.035	0.965	0.000
I44.5 Left posterior fascicular block	0.034	0.966	0.000
I44.4 Left anterior fascicular block	0.034	0.966	0.000
I50.9 Heart failure, unspecified	0.034	0.966	0.000
I47.9 Paroxysmal tachycardia, unspecified	0.034	0.966	0.000
# Top node	0.033	0.967	0.000
Chapter XX External causes of morbidity and mortality	0.033	0.967	0.000
J17 Pneumonia in diseases classified elsewhere	0.032	0.968	0.000
D58 Other hereditary haemolytic anaemias	0.032	0.968	0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.031	0.968	0.001
D56.3 Thalassaemia trait	0.031	0.968	0.000
F33 Recurrent depressive disorder	0.032	0.968	0.000
J38.0 Paralysis of vocal cords and larynx	0.031	0.968	0.000
J95-J99 Other diseases of the respiratory system	0.031	0.969	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.031	0.969	0.000
J18.8 Other pneumonia, organism unspecified	0.031	0.969	0.000
I34.2 Nonrheumatic mitral (valve) stenosis	0.031	0.969	0.000
D56.1 Beta thalassaemia	0.030	0.969	0.000
Chapter V Mental and behavioural disorders	0.031	0.969	0.000
J15 Bacterial pneumonia, not elsewhere classified	0.030	0.970	0.000
J14 Pneumonia due to Haemophilus influenzae	0.030	0.970	0.000
I34.0 Mitral (valve) insufficiency	0.030	0.970	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.030	0.970	0.000
I67.1 Cerebral aneurysm, nonruptured	0.030	0.970	0.000
F30-F39 Mood [affective] disorders	0.030	0.970	0.000
F33.9 Recurrent depressive disorder, unspecified	0.030	0.970	0.000
W75-W84 Other accidental threats to breathing	0.030	0.970	0.000
D56.9 Thalassaemia, unspecified	0.029	0.971	0.000
D56.8 Other thalassaemias	0.029	0.971	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.029	0.971	0.000
D56.2 Delta-beta thalassaemia	0.029	0.971	0.000
D56.0 Alpha thalassaemia	0.029	0.971	0.000
J80-J84 Other respiratory diseases principally affecting the interstitium	0.029	0.971	0.000
D17 Benign lipomatous neoplasm	0.029	0.971	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations