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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4713433
log Bayes Factor = 30.0504
Chromosome 6   position 31,068,026  (GRCh37) Explore rs4713433 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.002 0.998
E10-E14 Diabetes mellitus
0.000 0.006 0.994
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.007 0.993
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.010 0.990
E16 Other disorders of pancreatic internal secretion
0.000 0.011 0.989
E16.2 Hypoglycaemia, unspecified
0.000 0.012 0.988
M45.X9 Ankylosing spondylitis (Site unspecified)
0.987 0.013 0.000
G35 Multiple sclerosis
0.000 0.013 0.987
E00-E07 Disorders of thyroid gland
0.001 0.014 0.984
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.018 0.982
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.019 0.981
E10.1 With ketoacidosis
0.000 0.023 0.977
E03.9 Hypothyroidism, unspecified
0.969 0.031 0.000
E10.9 Without complications
0.000 0.035 0.965
L40.9 Psoriasis, unspecified
0.000 0.046 0.954
L40 Psoriasis
0.000 0.050 0.950
L40.5 Arthropathic psoriasis
0.000 0.053 0.947
E10.2 With renal complications
0.000 0.057 0.943
E06 Thyroiditis
0.000 0.097 0.902
M45 Ankylosing spondylitis
0.877 0.123 0.000
L40.0 Psoriasis vulgaris
0.000 0.136 0.864
E65-E68 Obesity and other hyperalimentation
0.000 0.167 0.833
E06.9 Thyroiditis, unspecified
0.000 0.185 0.815
E03 Other hypothyroidism
0.630 0.188 0.182
E10.5 With peripheral circulatory complications
0.000 0.207 0.793
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.789 0.211 0.000
E10.8 With unspecified complications
0.000 0.214 0.786
E05.8 Other thyrotoxicosis
0.000 0.221 0.779
E16.1 Other hypoglycaemia
0.000 0.224 0.776
E10.4 With neurological complications
0.000 0.240 0.760
M45.X2 Ankylosing spondylitis (Cervical region)
0.754 0.245 0.000
E13 Other specified diabetes mellitus
0.000 0.249 0.751
M45.X6 Ankylosing spondylitis (Lumbar region)
0.732 0.268 0.000
E10.6 With other specified complications
0.000 0.269 0.731
E06.3 Autoimmune thyroiditis
0.000 0.269 0.730
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E50-E64 Other nutritional deficiencies
0.000 0.286 0.714
E12 Malnutrition-related diabetes mellitus
0.000 0.287 0.713
E15 Nondiabetic hypoglycaemic coma
0.000 0.290 0.710
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.291 0.709
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.291 0.709
E16.4 Abnormal secretion of gastrin
0.000 0.291 0.709
E16.3 Increased secretion of glucagon
0.000 0.291 0.709
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.293 0.706
E00 Congenital iodine-deficiency syndrome
0.001 0.293 0.706
E02 Subclinical iodine-deficiency hypothyroidism
0.001 0.293 0.706
E05.5 Thyroid crisis or storm
0.000 0.296 0.704
E05.4 Thyrotoxicosis factitia
0.000 0.296 0.704
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.296 0.704
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.296 0.704
E10.0 With coma
0.000 0.296 0.704
L40.1 Generalised pustular psoriasis
0.000 0.316 0.684
L40.4 Guttate psoriasis
0.000 0.319 0.681
L40.3 Pustulosis palmaris et plantaris
0.000 0.319 0.681
L40.2 Acrodermatitis continua
0.000 0.319 0.681
E65 Localised adiposity
0.000 0.322 0.678
E66 Obesity
0.000 0.342 0.658
E06.5 Other chronic thyroiditis
0.000 0.353 0.647
E06.4 Drug-induced thyroiditis
0.000 0.353 0.647
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.353 0.647
E06.1 Subacute thyroiditis
0.000 0.353 0.647
E06.0 Acute thyroiditis
0.000 0.353 0.647
E11 Non-insulin-dependent diabetes mellitus
0.000 0.359 0.641
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.362 0.637
E55 Vitamin D deficiency
0.000 0.367 0.633
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.629 0.371 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.629 0.371 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.629 0.371 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.629 0.371 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.629 0.371 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.629 0.371 0.000
E40-E46 Malnutrition
0.000 0.393 0.607
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.499 0.396 0.105
E66.8 Other obesity
0.000 0.396 0.604
E67 Other hyperalimentation
0.000 0.403 0.597
E68 Sequelae of hyperalimentation
0.000 0.403 0.597
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.408 0.592
L40.8 Other psoriasis
0.000 0.416 0.584
E03.5 Myxoedema coma
0.452 0.417 0.131
E03.4 Atrophy of thyroid (acquired)
0.452 0.417 0.131
E03.3 Postinfectious hypothyroidism
0.452 0.417 0.131
E03.1 Congenital hypothyroidism without goitre
0.452 0.417 0.131
E03.0 Congenital hypothyroidism with diffuse goitre
0.452 0.417 0.131
E03.8 Other specified hypothyroidism
0.474 0.422 0.104
E13.9 Without complications
0.000 0.424 0.576
E55.9 Vitamin D deficiency, unspecified
0.000 0.425 0.575
K90 Intestinal malabsorption
0.000 0.433 0.567
E11.3 With ophthalmic complications
0.000 0.445 0.555
E11.6 With other specified complications
0.000 0.459 0.541
E13.8 With unspecified complications
0.000 0.462 0.538
E13.7 With multiple complications
0.000 0.462 0.538
E13.6 With other specified complications
0.000 0.462 0.538
E13.5 With peripheral circulatory complications
0.000 0.462 0.538
E13.4 With neurological complications
0.000 0.462 0.538
E13.3 With ophthalmic complications
0.000 0.462 0.538
E13.2 With renal complications
0.000 0.462 0.538
E13.1 With ketoacidosis
0.000 0.462 0.538
E13.0 With coma
0.000 0.462 0.538
E05.9 Thyrotoxicosis, unspecified
0.000 0.476 0.524
G37 Other demyelinating diseases of central nervous system
0.000 0.481 0.519
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.488 0.512
E63 Other nutritional deficiencies
0.000 0.488 0.512
E51 Thiamine deficiency
0.000 0.488 0.512
E50 Vitamin A deficiency
0.000 0.488 0.512
E60 Dietary zinc deficiency
0.000 0.488 0.512
E59 Dietary selenium deficiency
0.000 0.488 0.512
E58 Dietary calcium deficiency
0.000 0.488 0.512
E54 Ascorbic acid deficiency
0.000 0.488 0.512
E52 Niacin deficiency [pellagra]
0.000 0.488 0.512
E12.9 Without complications
0.000 0.489 0.511
E12.8 With unspecified complications
0.000 0.489 0.511
E12.7 With multiple complications
0.000 0.489 0.511
E12.6 With other specified complications
0.000 0.489 0.511
E12.5 With peripheral circulatory complications
0.000 0.489 0.511
E12.4 With neurological complications
0.000 0.489 0.511
E12.3 With ophthalmic complications
0.000 0.489 0.511
E12.2 With renal complications
0.000 0.489 0.511
E12.1 With ketoacidosis
0.000 0.489 0.511
E12.0 With coma
0.000 0.489 0.511
E66.0 Obesity due to excess calories
0.000 0.493 0.507
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.001 0.493 0.506
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.001 0.493 0.506
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.001 0.493 0.506
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.001 0.493 0.506
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.493 0.506
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.001 0.493 0.506
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.001 0.493 0.506
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.001 0.493 0.506
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.494 0.506
E11.8 With unspecified complications
0.000 0.506 0.494
E11.4 With neurological complications
0.000 0.506 0.494
L40-L45 Papulosquamous disorders
0.000 0.517 0.483
E66.1 Drug-induced obesity
0.000 0.528 0.472
E11.2 With renal complications
0.000 0.529 0.471
E07 Other disorders of thyroid
0.002 0.531 0.468
E11.7 With multiple complications
0.000 0.540 0.460
E61 Deficiency of other nutrient elements
0.000 0.544 0.455
E55.0 Rickets, active
0.000 0.546 0.454
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.548 0.452
E56 Other vitamin deficiencies
0.000 0.550 0.449
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.551 0.449
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.565 0.435
E45 Retarded development following protein-energy malnutrition
0.000 0.565 0.435
E43 Unspecified severe protein-energy malnutrition
0.000 0.565 0.435
E42 Marasmic kwashiorkor
0.000 0.565 0.435
E41 Nutritional marasmus
0.000 0.565 0.435
E40 Kwashiorkor
0.000 0.565 0.435
K90.9 Intestinal malabsorption, unspecified
0.000 0.568 0.432
E67.8 Other specified hyperalimentation
0.000 0.572 0.428
E67.3 Hypervitaminosis D
0.000 0.572 0.428
E67.2 Megavitamin-B6 syndrome
0.000 0.572 0.428
E67.1 Hypercarotenaemia
0.000 0.572 0.428
E67.0 Hypervitaminosis A
0.000 0.572 0.428
E70-E90 Metabolic disorders
0.000 0.573 0.427
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.582 0.418
E53 Deficiency of other B group vitamins
0.000 0.582 0.418
E83.1 Disorders of iron metabolism
0.000 0.583 0.417
E83 Disorders of mineral metabolism
0.000 0.585 0.415
G36 Other acute disseminated demyelination
0.000 0.591 0.409
K90.8 Other intestinal malabsorption
0.000 0.591 0.408
K90.3 Pancreatic steatorrhoea
0.000 0.594 0.406
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.594 0.406
K90.1 Tropical sprue
0.000 0.594 0.406
E11.1 With ketoacidosis
0.000 0.595 0.405
E14 Unspecified diabetes mellitus
0.000 0.605 0.395
E11.5 With peripheral circulatory complications
0.000 0.609 0.391
L42 Pityriasis rosea
0.000 0.613 0.387
E11.0 With coma
0.000 0.614 0.385
G37.5 Concentric sclerosis [Balo]
0.000 0.628 0.372
G37.4 Subacute necrotising myelitis
0.000 0.628 0.372
G37.2 Central pontine myelinolysis
0.000 0.628 0.372
G37.1 Central demyelination of corpus callosum
0.000 0.628 0.372
G37.0 Diffuse sclerosis
0.000 0.628 0.372
E50.9 Vitamin A deficiency, unspecified
0.000 0.633 0.367
E50.8 Other manifestations of vitamin A deficiency
0.000 0.633 0.367
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.633 0.367
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.633 0.367
E50.5 Vitamin A deficiency with night blindness
0.000 0.633 0.367
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.633 0.367
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.633 0.367
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.633 0.367
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.633 0.367
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.633 0.367
E51.9 Thiamine deficiency, unspecified
0.000 0.633 0.367
E51.8 Other manifestations of thiamine deficiency
0.000 0.633 0.367
E51.2 Wernicke's encephalopathy
0.000 0.633 0.367
E51.1 Beriberi
0.000 0.633 0.367
E63.9 Nutritional deficiency, unspecified
0.000 0.633 0.367
E63.8 Other specified nutritional deficiencies
0.000 0.633 0.367
E63.1 Imbalance of constituents of food intake
0.000 0.633 0.367
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.633 0.367
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.633 0.367
E64.8 Sequelae of other nutritional deficiencies
0.000 0.633 0.367
E64.3 Sequelae of rickets
0.000 0.633 0.367
E64.2 Sequelae of vitamin C deficiency
0.000 0.633 0.367
E64.1 Sequelae of vitamin A deficiency
0.000 0.633 0.367
E64.0 Sequelae of protein-energy malnutrition
0.000 0.633 0.367
E85 Amyloidosis
0.000 0.641 0.359
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.641 0.359
L43 Lichen planus
0.000 0.653 0.346
L44 Other papulosquamous disorders
0.000 0.654 0.346
L41 Parapsoriasis
0.000 0.654 0.346
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.654 0.346
E07.8 Other specified disorders of thyroid
0.001 0.659 0.340
E83.5 Disorders of calcium metabolism
0.000 0.662 0.338
E07.1 Dyshormogenetic goitre
0.001 0.663 0.335
E07.0 Hypersecretion of calcitonin
0.001 0.663 0.335
E46 Unspecified protein-energy malnutrition
0.000 0.670 0.330
E61.2 Magnesium deficiency
0.000 0.671 0.329
E53.9 Vitamin B deficiency, unspecified
0.000 0.672 0.328
E61.9 Deficiency of nutrient element, unspecified
0.000 0.673 0.327
E61.8 Deficiency of other specified nutrient elements
0.000 0.673 0.327
E61.7 Deficiency of multiple nutrient elements
0.000 0.673 0.327
E61.6 Vanadium deficiency
0.000 0.673 0.327
E61.5 Molybdenum deficiency
0.000 0.673 0.327
E61.4 Chromium deficiency
0.000 0.673 0.327
E61.3 Manganese deficiency
0.000 0.673 0.327
E61.0 Copper deficiency
0.000 0.673 0.327
E56.9 Vitamin deficiency, unspecified
0.000 0.677 0.322
E56.8 Deficiency of other vitamins
0.000 0.677 0.322
E56.0 Deficiency of vitamin E
0.000 0.677 0.322
E44.1 Mild protein-energy malnutrition
0.000 0.688 0.312
E44.0 Moderate protein-energy malnutrition
0.000 0.688 0.312
E85.4 Organ-limited amyloidosis
0.000 0.692 0.308
E14.4 With neurological complications
0.000 0.693 0.307
E84 Cystic fibrosis
0.000 0.693 0.306
E79 Disorders of purine and pyrimidine metabolism
0.000 0.693 0.306
E77 Disorders of glycoprotein metabolism
0.000 0.693 0.306
E76 Disorders of glycosaminoglycan metabolism
0.000 0.693 0.306
E72 Other disorders of amino-acid metabolism
0.000 0.693 0.306
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.693 0.306
E70 Disorders of aromatic amino-acid metabolism
0.000 0.693 0.306
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.693 0.306
E88 Other metabolic disorders
0.000 0.694 0.306
E53.1 Pyridoxine deficiency
0.000 0.700 0.300
E53.0 Riboflavin deficiency
0.000 0.700 0.300
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.702 0.298
E83.8 Other disorders of mineral metabolism
0.000 0.702 0.298
E83.2 Disorders of zinc metabolism
0.000 0.702 0.298
E83.0 Disorders of copper metabolism
0.000 0.702 0.298
E74 Other disorders of carbohydrate metabolism
0.000 0.705 0.294
G36.9 Acute disseminated demyelination, unspecified
0.000 0.706 0.293
G36.8 Other specified acute disseminated demyelination
0.000 0.706 0.293
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.706 0.293
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.710 0.290
E14.1 With ketoacidosis
0.000 0.715 0.285
L43.8 Other lichen planus
0.000 0.716 0.284
E14.8 With unspecified complications
0.000 0.716 0.284
E14.7 With multiple complications
0.000 0.716 0.284
E14.2 Withrenal complications
0.000 0.716 0.284
E14.0 With coma
0.000 0.716 0.284
G36.0 Neuromyelitis optica [Devic]
0.000 0.722 0.278
E73 Lactose intolerance
0.000 0.725 0.275
E14.3 With ophthalmic complications
0.000 0.732 0.268
E61.1 Iron deficiency
0.000 0.733 0.267
E14.6 With other specified complications
0.000 0.734 0.265
E85.9 Amyloidosis, unspecified
0.000 0.736 0.264
E56.1 Deficiency of vitamin K
0.001 0.740 0.260
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.742 0.258
E85.8 Other amyloidosis
0.000 0.742 0.258
E85.3 Secondary systemic amyloidosis
0.000 0.742 0.258
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.742 0.258
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.742 0.258
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.742 0.258
E86 Volume depletion
0.000 0.745 0.255
E14.5 With peripheral circulatory complications
0.000 0.751 0.249
L43.3 Subacute (active) lichen planus
0.000 0.751 0.248
L43.2 Lichenoid drug reaction
0.000 0.751 0.248
L43.1 Bullous lichen planus
0.000 0.751 0.248
L43.0 Hypertrophic lichen planus
0.000 0.751 0.248
L41.9 Parapsoriasis, unspecified
0.000 0.752 0.248
L41.8 Other parapsoriasis
0.000 0.752 0.248
L41.5 Retiform parapsoriasis
0.000 0.752 0.248
L41.4 Large plaque parapsoriasis
0.000 0.752 0.248
L41.3 Small plaque parapsoriasis
0.000 0.752 0.248
L41.2 Lymphomatoid papulosis
0.000 0.752 0.248
L41.1 Pityriasis lichenoides chronica
0.000 0.752 0.248
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.752 0.248
L44.9 Papulosquamous disorder, unspecified
0.000 0.752 0.248
L44.8 Other specified papulosquamous disorders
0.000 0.752 0.248
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.752 0.248
L44.3 Lichen ruber moniliformis
0.000 0.752 0.248
L44.2 Lichen striatus
0.000 0.752 0.248
L44.1 Lichen nitidus
0.000 0.752 0.248
L44.0 Pityriasis rubra pilaris
0.000 0.752 0.248
E04 Other non-toxic goitre
0.000 0.752 0.247
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.763 0.237
E88.2 Lipomatosis, not elsewhere classified
0.000 0.764 0.235
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.780 0.220
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.780 0.220
E70.3 Albinism
0.000 0.780 0.220
E70.2 Disorders of tyrosine metabolism
0.000 0.780 0.220
E70.1 Other hyperphenylalaninaemias
0.000 0.780 0.220
E70.0 Classical phenylketonuria
0.000 0.780 0.220
E71.3 Disorders of fatty-acid metabolism
0.000 0.780 0.220
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.780 0.220
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.780 0.220
E71.0 Maple-syrup-urine disease
0.000 0.780 0.220
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.780 0.220
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.780 0.220
E72.5 Disorders of glycine metabolism
0.000 0.780 0.220
E72.4 Disorders of ornithine metabolism
0.000 0.780 0.220
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.780 0.220
E72.2 Disorders of urea cycle metabolism
0.000 0.780 0.220
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.780 0.220
E72.0 Disorders of amino-acid transport
0.000 0.780 0.220
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.780 0.220
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.780 0.220
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.780 0.220
E76.2 Other mucopolysaccharidoses
0.000 0.780 0.220
E76.1 Mucopolysaccharidosis, type II
0.000 0.780 0.220
E76.0 Mucopolysaccharidosis, type I
0.000 0.780 0.220
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.780 0.220
E77.8 Other disorders of glycoprotein metabolism
0.000 0.780 0.220
E77.1 Defects in glycoprotein degradation
0.000 0.780 0.220
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.780 0.220
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.780 0.220
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.780 0.220
E79.1 Lesch-Nyhan syndrome
0.000 0.780 0.220
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.780 0.220
E84.9 Cystic fibrosis, unspecified
0.000 0.780 0.220
E84.8 Cystic fibrosis with other manifestations
0.000 0.780 0.220
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.780 0.220
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.780 0.220
E88.9 Metabolic disorder, unspecified
0.000 0.780 0.220
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.789 0.211
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.789 0.211
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.789 0.211
E74.2 Disorders of galactose metabolism
0.000 0.789 0.211
E74.1 Disorders of fructose metabolism
0.000 0.789 0.211
E74.0 Glycogen storage disease
0.000 0.789 0.211
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.791 0.209
E89.2 Postprocedural hypoparathyroidism
0.000 0.791 0.209
E75.6 Lipid storage disorder, unspecified
0.000 0.792 0.208
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.792 0.208
E75.3 Sphingolipidosis, unspecified
0.000 0.792 0.208
E75.2 Other sphingolipidosis
0.000 0.792 0.208
E75.1 Other gangliosidosis
0.000 0.792 0.208
E75.0 GM2 gangliosidosis
0.000 0.792 0.208
E88.8 Other specified metabolic disorders
0.000 0.794 0.206
E88.3 Tumour lysis syndrome
0.000 0.795 0.205
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.801 0.199
E73.8 Other lactose intolerance
0.000 0.803 0.197
E73.1 Secondary lactase deficiency
0.000 0.803 0.197
E73.0 Congenital lactase deficiency
0.000 0.803 0.197
L43.9 Lichen planus, unspecified
0.000 0.806 0.194
E75.5 Other lipid storage disorders
0.000 0.808 0.191
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.815 0.185
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.815 0.185
E89.5 Postprocedural testicular hypofunction
0.000 0.815 0.185
E89.1 Postprocedural hypoinsulinaemia
0.000 0.815 0.185
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.821 0.178
E04.8 Other specified non-toxic goitre
0.000 0.822 0.178
E04.0 Non-toxic diffuse goitre
0.000 0.822 0.177
E83.4 Disorders of magnesium metabolism
0.000 0.823 0.177
E89.0 Postprocedural hypothyroidism
0.000 0.827 0.173
E89.4 Postprocedural ovarian failure
0.000 0.829 0.170
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.832 0.168
E04.9 Non-toxic goitre, unspecified
0.000 0.833 0.167
E73.9 Lactose intolerance, unspecified
0.000 0.834 0.166
E20-E35 Disorders of other endocrine glands
0.001 0.839 0.160
E83.3 Disorders of phosphorus metabolism
0.000 0.852 0.148
E89.3 Postprocedural hypopituitarism
0.000 0.860 0.140
E53.8 Deficiency of other specified B group vitamins
0.000 0.863 0.137
M06.9 Rheumatoid arthritis, unspecified
0.124 0.876 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.122 0.878 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.879 0.121
E80.5 Crigler-Najjar syndrome
0.000 0.879 0.121
E80.3 Defects of catalase and peroxydase
0.000 0.879 0.121
E80.1 Porphyria cutanea tarda
0.000 0.879 0.121
E80.0 Hereditary erythropoietic porphyria
0.000 0.879 0.121
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.880 0.119
E22 Hyperfunction of pituitary gland
0.000 0.883 0.117
E35 Disorders of endocrine glands in diseases classified elsewhere
0.001 0.884 0.115
E32 Diseases of thymus
0.001 0.884 0.115
E31 Polyglandular dysfunction
0.001 0.884 0.115
E30 Disorders of puberty, not elsewhere classified
0.001 0.884 0.115
E25 Adrenogenital disorders
0.001 0.884 0.115
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.114 0.886 0.000
E20 Hypoparathyroidism
0.001 0.887 0.112
M06 Other rheumatoid arthritis
0.112 0.888 0.000
E80.6 Other disorders of bilirubin metabolism
0.000 0.892 0.108
M06.0 Seronegative rheumatoid arthritis
0.107 0.893 0.000
E80.2 Other porphyria
0.000 0.894 0.106
E27 Other disorders of adrenal gland
0.000 0.894 0.106
E34 Other endocrine disorders
0.001 0.895 0.104
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.103 0.897 0.000
M45-M49 Spondylopathies
0.103 0.897 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.102 0.898 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.899 0.101
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.100 0.900 0.000
E22.1 Hyperprolactinaemia
0.000 0.900 0.100
E29 Testicular dysfunction
0.001 0.901 0.099
E26 Hyperaldosteronism
0.001 0.901 0.099
E24 Cushing's syndrome
0.001 0.901 0.099
E21.0 Primary hyperparathyroidism
0.000 0.901 0.099
M06.3 Rheumatoid nodule
0.096 0.903 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.096 0.904 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.096 0.904 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.095 0.905 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.907 0.093
E23 Hypofunction and other disorders of pituitary gland
0.001 0.908 0.091
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.908 0.091
M06.98 Rheumatoid arthritis, unspecified (Other)
0.090 0.910 0.000
M06.34 Rheumatoid nodule (Hand)
0.088 0.912 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.913 0.087
E07.9 Disorder of thyroid, unspecified
0.002 0.913 0.084
E21.4 Other specified disorders of parathyroid gland
0.000 0.914 0.086
E21.2 Other hyperparathyroidism
0.000 0.914 0.086
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.086 0.914 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.916 0.084
E22.8 Other hyperfunction of pituitary gland
0.000 0.916 0.084
E34.0 Carcinoid syndrome
0.000 0.916 0.084
E04.2 Non-toxic multinodular goitre
0.000 0.916 0.083
E25.9 Adrenogenital disorder, unspecified
0.001 0.917 0.083
E25.8 Other adrenogenital disorders
0.001 0.917 0.083
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.917 0.083
E30.9 Disorder of puberty, unspecified
0.001 0.917 0.083
E30.8 Other disorders of puberty
0.001 0.917 0.083
E30.1 Precocious puberty
0.001 0.917 0.083
E30.0 Delayed puberty
0.001 0.917 0.083
E31.9 Polyglandular dysfunction, unspecified
0.001 0.917 0.083
E31.8 Other polyglandular dysfunction
0.001 0.917 0.083
E31.1 Polyglandular hyperfunction
0.001 0.917 0.083
E31.0 Autoimmune polyglandular failure
0.001 0.917 0.083
E32.9 Disease of thymus, unspecified
0.001 0.917 0.083
E32.8 Other diseases of thymus
0.001 0.917 0.083
E32.1 Abscess of thymus
0.001 0.917 0.083
E32.0 Persistent hyperplasia of thymus
0.001 0.917 0.083
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.001 0.917 0.083
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.001 0.917 0.083
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.001 0.917 0.083
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.083 0.917 0.000
E20.8 Other hypoparathyroidism
0.001 0.919 0.081
E20.1 Pseudohypoparathyroidism
0.001 0.919 0.081
E20.0 Idiopathic hypoparathyroidism
0.001 0.919 0.081
M06.8 Other specified rheumatoid arthritis
0.081 0.919 0.000
M06.2 Rheumatoid bursitis
0.081 0.919 0.000
M06.1 Adult-onset Still's disease
0.081 0.919 0.000
E87.5 Hyperkalaemia
0.000 0.921 0.079
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.079 0.921 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.922 0.077
M06.08 Seronegative rheumatoid arthritis (Other)
0.077 0.923 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.077 0.923 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.077 0.923 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.077 0.923 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.077 0.923 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.077 0.923 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.077 0.923 0.000
E23.6 Other disorders of pituitary gland
0.000 0.923 0.076
E27.8 Other specified disorders of adrenal gland
0.000 0.924 0.076
E14.9 Without complications
0.000 0.924 0.076
M06.4 Inflammatory polyarthropathy
0.076 0.924 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.924 0.076
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.924 0.076
E27.0 Other adrenocortical overactivity
0.000 0.924 0.076
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.924 0.075
E34.5 Androgen resistance syndrome
0.001 0.925 0.075
E34.4 Constitutional tall stature
0.001 0.925 0.075
E34.3 Short stature, not elsewhere classified
0.001 0.925 0.075
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.925 0.075
E34.1 Other hypersecretion of intestinal hormones
0.001 0.925 0.075
M46 Other inflammatory spondylopathies
0.073 0.927 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.928 0.071
E29.9 Testicular dysfunction, unspecified
0.001 0.928 0.071
E29.8 Other testicular dysfunction
0.001 0.928 0.071
E29.0 Testicular hyperfunction
0.001 0.928 0.071
E26.9 Hyperaldosteronism, unspecified
0.001 0.929 0.071
E26.8 Other hyperaldosteronism
0.001 0.929 0.071
E26.1 Secondary hyperaldosteronism
0.001 0.929 0.071
E24.8 Other Cushing's syndrome
0.001 0.929 0.071
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.001 0.929 0.071
E24.3 Ectopic ACTH syndrome
0.001 0.929 0.071
E24.1 Nelson's syndrome
0.001 0.929 0.071
E24.0 Pituitary-dependent Cushing's disease
0.001 0.929 0.071
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.071 0.929 0.000
E34.9 Endocrine disorder, unspecified
0.001 0.930 0.070
E87.2 Acidosis
0.000 0.930 0.070
M06.37 Rheumatoid nodule (Ankle and foot)
0.070 0.930 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.930 0.070
M06.39 Rheumatoid nodule (Site unspecified)
0.069 0.930 0.000
M06.38 Rheumatoid nodule (Other)
0.069 0.930 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.069 0.930 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.069 0.930 0.000
M06.33 Rheumatoid nodule (Forearm)
0.069 0.930 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.069 0.930 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.069 0.930 0.000
E87.7 Fluid overload
0.000 0.931 0.069
M49 Spondylopathies in diseases classified elsewhere
0.067 0.933 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.933 0.066
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.001 0.934 0.066
E23.1 Drug-induced hypopituitarism
0.001 0.934 0.066
E87.4 Mixed disorder of acid-base balance
0.000 0.934 0.066
E24.2 Drug-induced Cushing's syndrome
0.001 0.935 0.064
E27.9 Disorder of adrenal gland, unspecified
0.000 0.935 0.065
E24.9 Cushing's syndrome, unspecified
0.001 0.937 0.063
M06.32 Rheumatoid nodule (Upper arm)
0.062 0.938 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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