TreeWAS – Variant ID: rs4948589

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I25 Chronic ischaemic heart disease	0.000	0.000	1.000
I20-I25 Ischaemic heart diseases	0.000	0.000	1.000
I25.1 Atherosclerotic heart disease	0.000	0.000	1.000
I20 Angina pectoris	0.000	0.000	1.000
I21 Acute myocardial infarction	0.000	0.000	1.000
I25.8 Other forms of chronic ischaemic heart disease	0.000	0.000	1.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.000	1.000
I20.9 Angina pectoris, unspecified	0.000	0.001	0.999
I22 Subsequent myocardial infarction	0.000	0.001	0.999
I20.8 Other forms of angina pectoris	0.000	0.002	0.998
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.005	0.995
I21.9 Acute myocardial infarction, unspecified	0.000	0.012	0.988
I25.2 Old myocardial infarction	0.000	0.020	0.980
I25.9 Chronic ischaemic heart disease, unspecified	0.000	0.065	0.935
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.139	0.861
I22.8 Subsequent myocardial infarction of other sites	0.000	0.177	0.822
I25.3 Aneurysm of heart	0.000	0.195	0.805
I24 Other acute ischaemic heart diseases	0.000	0.209	0.791
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.217	0.783
I21.3 Acute transmural myocardial infarction of unspecified site	0.000	0.250	0.750
I25.6 Silent myocardial ischaemia	0.000	0.283	0.717
I21.X Presumed acute myicardial infaction (unconfirmed)	0.000	0.283	0.717
Z95.5 Presence of coronary angioplasty implant and graft	0.000	0.288	0.712
I21.1 Acute transmural myocardial infarction of inferior wall	0.000	0.292	0.708
I25.4 Coronary artery aneurysm	0.000	0.315	0.685
I25.5 Ischaemic cardiomyopathy	0.000	0.318	0.682
I24.8 Other forms of acute ischaemic heart disease	0.000	0.319	0.681
I24.1 Dressler's syndrome	0.000	0.376	0.624
I25.0 Atherosclerotic cardiovascular disease, so described	0.000	0.378	0.622
I24.9 Acute ischaemic heart disease, unspecified	0.000	0.385	0.615
I23 Certain current complications following acute myocardial infarction	0.000	0.417	0.582
I21.4 Acute subendocardial myocardial infarction	0.000	0.500	0.500
Z95.1 Presence of aortocoronary bypass graft	0.000	0.501	0.499
Z95 Presence of cardiac and vascular implants and grafts	0.000	0.507	0.493
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.000	0.553	0.447
I20.1 Angina pectoris with documented spasm	0.000	0.573	0.426
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.000	0.582	0.418
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.000	0.582	0.418
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.000	0.582	0.418
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.000	0.582	0.418
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.000	0.582	0.418
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.000	0.582	0.418
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.000	0.582	0.418
I21.2 Acute transmural myocardial infarction of other sites	0.001	0.700	0.300
I23.8 Other current complications following acute myocardial infarction	0.001	0.716	0.283
Z95.8 Presence of other cardiac and vascular implants and grafts	0.000	0.718	0.282
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.000	0.723	0.276
Z95.0 Presence of cardiac pacemaker	0.000	0.739	0.261
I20.0 Unstable angina	0.000	0.812	0.188
Z95.3 Presence of xenogenic heart valve	0.001	0.858	0.141
F17.2 Dependence syndrome	0.000	0.934	0.066
Z95.2 Presence of prosthetic heart valve	0.000	0.967	0.033
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system	0.000	0.969	0.031
D05.1 Intraductal carcinoma in situ	0.000	0.971	0.029
Z95.4 Presence of other heart-valve replacement	0.001	0.972	0.027
Z35.2 Supervision of pregnancy with other poor reproductive or obstetric history	0.023	0.977	0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.000	0.981	0.019
I78.1 Naevus, nonneoplastic	0.014	0.986	0.000
M24.54 Contracture of joint (Hand)	0.013	0.987	0.000
M24.5 Contracture of joint	0.012	0.988	0.000
S82.8 Fractures of other parts of lower leg	0.000	0.988	0.012
S82.81 Fractures of other parts of lower leg (open)	0.000	0.988	0.012
Z82 Family history of certain disabilities and chronic diseases leading to disablement	0.000	0.988	0.012
Z82.3 Family history of stroke	0.000	0.988	0.012
S82.80 Fractures of other parts of lower leg (closed)	0.000	0.989	0.011
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.011	0.989	0.000
S82 Fracture of lower leg, including ankle	0.000	0.989	0.011
M24 Other specific joint derangements	0.011	0.989	0.000
F17 Mental and behavioural disorders due to use of tobacco	0.000	0.989	0.011
I70.2 Atherosclerosis of arteries of the extremities	0.011	0.989	0.000
M24.1 Other articular cartilage disorders	0.010	0.990	0.000
I78 Diseases of capillaries	0.010	0.990	0.000
S82.30 Fracture of lower end of tibia (closed)	0.000	0.990	0.010
S82.3 Fracture of lower end of tibia	0.000	0.990	0.010
M24.52 Contracture of joint (Upper arm)	0.010	0.990	0.000
M24.55 Contracture of joint (Pelvic region and thigh)	0.010	0.990	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.010	0.990	0.000
Z82.5 Family history of asthma and other chronic lower respiratory diseases	0.000	0.990	0.010
S82.6 Fracture of lateral malleolus	0.000	0.990	0.010
I78.0 Hereditary haemorrhagic telangiectasia	0.010	0.990	0.000
M24.2 Disorder of ligament	0.010	0.990	0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)	0.009	0.991	0.000
I70.00 Atherosclerosis of aorta (without gangrene)	0.009	0.991	0.000
M24.57 Contracture of joint (Ankle and foot)	0.009	0.991	0.000
I70 Atherosclerosis	0.009	0.991	0.000
I70.0 Atherosclerosis of aorta	0.009	0.991	0.000
M24.28 Disorder of ligament (Other)	0.009	0.991	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.009	0.991	0.000
H72.9 Perforation of tympanic membrane, unspecified	0.000	0.991	0.009
S82.2 Fracture of shaft of tibia	0.000	0.991	0.009
M24.59 Contracture of joint (Site unspecified)	0.009	0.991	0.000
M24.58 Contracture of joint (Other)	0.009	0.991	0.000
M24.53 Contracture of joint (Forearm)	0.009	0.991	0.000
M24.50 Contracture of joint (Multiple sites)	0.009	0.991	0.000
M24.9 Joint derangement, unspecified	0.009	0.991	0.000
I49.5 Sick sinus syndrome	0.000	0.991	0.009
S82.86 Maisonneuve's fracture	0.000	0.991	0.009
M24.51 Contracture of joint (Shoulder region)	0.009	0.991	0.000
S82.60 Fracture of lateral malleolus (closed)	0.000	0.991	0.009
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.009	0.991	0.000
Z82.2 Family history of deafness and hearing loss	0.000	0.991	0.009
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified	0.000	0.991	0.009
M24.16 Other articular cartilage disorders (Lower leg)	0.009	0.991	0.000
S82.1 Fracture of upper end of tibia	0.000	0.991	0.009
M24.6 Ankylosis of joint	0.008	0.992	0.000
M24.21 Disorder of ligament (Shoulder region)	0.008	0.992	0.000
M24.0 Loose body in joint	0.008	0.992	0.000
S82.4 Fracture of fibula alone	0.000	0.992	0.008
S82.7 Multiple fractures of lower leg	0.000	0.992	0.008
S82.0 Fracture of patella	0.000	0.992	0.008
M24.4 Recurrent dislocation and subluxation of joint	0.008	0.992	0.000
S82.9 Fracture of lower leg, part unspecified	0.000	0.992	0.008
M24.56 Contracture of joint (Lower leg)	0.008	0.992	0.000
F17.8 Other mental and behavioural disorders	0.000	0.992	0.008
F17.7 Residual and late-onset psychotic disorder	0.000	0.992	0.008
F17.6 Amnesic syndrome	0.000	0.992	0.008
F17.5 Psychotic disorder	0.000	0.992	0.008
F17.4 Withdrawal state with delirium	0.000	0.992	0.008
F17.3 Withdrawal state	0.000	0.992	0.008
F17.0 Acute intoxication	0.000	0.992	0.008
S82.21 Fracture of shaft of tibia (open)	0.000	0.992	0.008
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.008	0.992	0.000
H72.0 Central perforation of tympanic membrane	0.000	0.992	0.008
M24.19 Other articular cartilage disorders (Site unspecified)	0.008	0.992	0.000
M24.18 Other articular cartilage disorders (Other)	0.008	0.992	0.000
M24.14 Other articular cartilage disorders (Hand)	0.008	0.992	0.000
M24.12 Other articular cartilage disorders (Upper arm)	0.008	0.992	0.000
M24.10 Other articular cartilage disorders (Multiple sites)	0.008	0.992	0.000
I78.9 Disease of capillaries, unspecified	0.008	0.992	0.000
M24.07 Loose body in joint (Ankle and foot)	0.008	0.992	0.000
I49.8 Other specified cardiac arrhythmias	0.000	0.992	0.008
M24.17 Other articular cartilage disorders (Ankle and foot)	0.008	0.992	0.000
S82.5 Fracture of medial malleolus	0.000	0.992	0.007
M24.96 Joint derangement, unspecified (Lower leg)	0.007	0.992	0.000
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.007	0.992	0.000
M24.26 Disorder of ligament (Lower leg)	0.007	0.993	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.007	0.993	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.007	0.993	0.000
M24.7 Protrusio acetabuli	0.007	0.993	0.000
M24.05 Loose body in joint (Pelvic region and thigh)	0.007	0.993	0.000
F17.9 Unspecified mental and behavioural disorder	0.000	0.993	0.007
S82.61 Fracture of lateral malleolus (open)	0.000	0.993	0.007
H72 Perforation of tympanic membrane	0.000	0.993	0.007
Z82.1 Family history of blindness and visual loss	0.000	0.993	0.007
M24.29 Disorder of ligament (Site unspecified)	0.007	0.993	0.000
M24.25 Disorder of ligament (Pelvic region and thigh)	0.007	0.993	0.000
M24.22 Disorder of ligament (Upper arm)	0.007	0.993	0.000
M24.20 Disorder of ligament (Multiple sites)	0.007	0.993	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.007	0.993	0.000
M24.64 Ankylosis of joint (Hand)	0.007	0.993	0.000
S82.31 Fracture of lower end of tibia (open)	0.000	0.993	0.007
I70.9 Generalised and unspecified atherosclerosis	0.007	0.993	0.000
I70.8 Atherosclerosis of other arteries	0.007	0.993	0.000
I78.8 Other diseases of capillaries	0.007	0.993	0.000
I70.01 Atherosclerosis of aorta (with gangrene)	0.007	0.993	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.007	0.993	0.000
M24.13 Other articular cartilage disorders (Forearm)	0.007	0.993	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.007	0.993	0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.007	0.993	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.007	0.993	0.000
I49 Other cardiac arrhythmias	0.000	0.993	0.007
M24.99 Joint derangement, unspecified (Site unspecified)	0.007	0.993	0.000
M24.98 Joint derangement, unspecified (Other)	0.007	0.993	0.000
M24.97 Joint derangement, unspecified (Ankle and foot)	0.007	0.993	0.000
M24.95 Joint derangement, unspecified (Pelvic region and thigh)	0.007	0.993	0.000
M24.94 Joint derangement, unspecified (Hand)	0.007	0.993	0.000
M24.93 Joint derangement, unspecified (Forearm)	0.007	0.993	0.000
M24.92 Joint derangement, unspecified (Upper arm)	0.007	0.993	0.000
M24.91 Joint derangement, unspecified (Shoulder region)	0.007	0.993	0.000
M24.90 Joint derangement, unspecified (Multiple sites)	0.007	0.993	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.007	0.993	0.000
I49.3 Ventricular premature depolarisation	0.000	0.993	0.007
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue	0.000	0.993	0.007
S82.10 Fracture of upper end of tibia (closed)	0.000	0.993	0.007
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.007	0.993	0.000
S82.40 Fracture of fibula alone (closed)	0.000	0.993	0.007
S82.11 Fracture of upper end of tibia (open)	0.000	0.993	0.006
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities	0.000	0.993	0.006
M24.24 Disorder of ligament (Hand)	0.006	0.993	0.000
M24.67 Ankylosis of joint (Ankle and foot)	0.006	0.993	0.000
S82.00 Fracture of patella (closed)	0.000	0.994	0.006
M80.9 Unspecified osteoporosis with pathological fracture	0.000	0.994	0.006
M24.44 Recurrent dislocation and subluxation of joint (Hand)	0.006	0.994	0.000
M24.04 Loose body in joint (Hand)	0.006	0.994	0.000
M24.69 Ankylosis of joint (Site unspecified)	0.006	0.994	0.000
M24.68 Ankylosis of joint (Other)	0.006	0.994	0.000
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.006	0.994	0.000
M24.63 Ankylosis of joint (Forearm)	0.006	0.994	0.000
M24.62 Ankylosis of joint (Upper arm)	0.006	0.994	0.000
M24.61 Ankylosis of joint (Shoulder region)	0.006	0.994	0.000
M24.60 Ankylosis of joint (Multiple sites)	0.006	0.994	0.000
S82.70 Multiple fractures of lower leg (closed)	0.000	0.994	0.006
S82.41 Fracture of fibula alone (open)	0.000	0.994	0.006
M24.09 Loose body in joint (Site unspecified)	0.006	0.994	0.000
M24.08 Loose body in joint (Other)	0.006	0.994	0.000
M24.06 Loose body in joint-Lower leg	0.006	0.994	0.000
M24.03 Loose body in joint (Forearm)	0.006	0.994	0.000
M24.00 Loose body in joint (Multiple sites)	0.006	0.994	0.000
I70.1 Atherosclerosis of renal artery	0.006	0.994	0.000
S82.71 Multiple fractures of lower leg (open)	0.000	0.994	0.006
D05 Carcinoma in situ of breast	0.000	0.994	0.006
M24.49 Recurrent dislocation and subluxation of joint (Site unspecified)	0.006	0.994	0.000
M24.48 Recurrent dislocation and subluxation of joint (Other)	0.006	0.994	0.000
M24.46 Recurrent dislocation and subluxation of joint (Lower leg)	0.006	0.994	0.000
M24.43 Recurrent dislocation and subluxation of joint (Forearm)	0.006	0.994	0.000
M24.42 Recurrent dislocation and subluxation of joint (Upper arm)	0.006	0.994	0.000
M24.40 Recurrent dislocation and subluxation of joint (Multiple sites)	0.006	0.994	0.000
D47.3 Essential (haemorrhagic) thrombocythaemia	0.000	0.994	0.006
S82.01 Fracture of patella (open)	0.000	0.994	0.006
I70-I79 Diseases of arteries, arterioles and capillaries	0.006	0.994	0.000
S82.91 Fracture of lower leg, part unspecified (open)	0.000	0.994	0.006
S82.20 Fracture of shaft of tibia (closed)	0.000	0.994	0.006
S82.90 Fracture of lower leg, part unspecified (closed)	0.000	0.994	0.006
M24.27 Disorder of ligament (Ankle and foot)	0.006	0.994	0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system	0.000	0.994	0.006
I49.9 Cardiac arrhythmia, unspecified	0.000	0.994	0.006
D47.2 Monoclonal gammopathy	0.000	0.994	0.006
M24.66 Ankylosis of joint (Lower leg)	0.006	0.994	0.000
H72.1 Attic perforation of tympanic membrane	0.000	0.994	0.006
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.005	0.994	0.000
S82.51 Fracture of medial malleolus (open)	0.000	0.994	0.006
M24.39 Pathological dislocation and subluxation of joint, not elsewhere classified (Site unspecified)	0.005	0.994	0.000
M24.38 Pathological dislocation and subluxation of joint, not elsewhere classified (Other)	0.005	0.994	0.000
M24.36 Pathological dislocation and subluxation of joint, not elsewhere classified (Lower leg)	0.005	0.994	0.000
M24.35 Pathological dislocation and subluxation of joint, not elsewhere classified (Pelvic region and thigh)	0.005	0.994	0.000
M24.34 Pathological dislocation and subluxation of joint, not elsewhere classified (Hand)	0.005	0.994	0.000
M24.33 Pathological dislocation and subluxation of joint, not elsewhere classified (Forearm)	0.005	0.994	0.000
M24.32 Pathological dislocation and subluxation of joint, not elsewhere classified (Upper arm)	0.005	0.994	0.000
M24.31 Pathological dislocation and subluxation of joint, not elsewhere classified (Shoulder region)	0.005	0.994	0.000
M24.30 Pathological dislocation and subluxation of joint, not elsewhere classified (Multiple sites)	0.005	0.994	0.000
M24.79 Protrusio acetabuli-Site unspec	0.005	0.994	0.000
M24.78 Protrusio acetabuli-Other	0.005	0.994	0.000
M24.77 Protrusio acetabuli-Ankle/foot	0.005	0.994	0.000
M24.76 Protrusio acetabuli-Lower leg	0.005	0.994	0.000
M24.74 Protrusio acetabuli-Hand	0.005	0.994	0.000
M24.73 Protrusio acetabuli-Forearm	0.005	0.994	0.000
M24.72 Protrusio acetabuli-Upper arm	0.005	0.994	0.000
M24.71 Protrusio acetabuli-Shldr region	0.005	0.994	0.000
M24.70 Protrusio acetabuli-Mult sites	0.005	0.994	0.000
M24.23 Disorder of ligament (Forearm)	0.005	0.995	0.000
W29.9 Unspecified place	0.000	0.995	0.005
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)	0.005	0.995	0.000
D05.7 Other carcinoma in situ of breast	0.000	0.995	0.005
I70.81 Atherosclerosis of other arteries (with gangrene)	0.005	0.995	0.000
I70.80 Atherosclerosis of other arteries (without gangrene)	0.005	0.995	0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)	0.005	0.995	0.000
I70.90 Generalized and unspecified atherosclerosis (without gangrene)	0.005	0.995	0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.000	0.995	0.005
H72.2 Other marginal perforations of tympanic membrane	0.000	0.995	0.005
N80.9 Endometriosis, unspecified	0.005	0.995	0.000
I49.2 Junctional premature depolarisation	0.000	0.995	0.005
S82.50 Fracture of medial malleolus (closed)	0.000	0.995	0.005
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.005	0.995	0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)	0.005	0.995	0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.000	0.995	0.005
M24.37 Pathological dislocation and subluxation of joint, not elsewhere classified (Ankle and foot)	0.005	0.995	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.000	0.995	0.005
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.000	0.995	0.005
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.995	0.005
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.000	0.995	0.005
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.000	0.995	0.005
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.000	0.995	0.005
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.000	0.995	0.005
I70.11 Atherosclerosis of renal artery (with gangrene)	0.005	0.995	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.005	0.995	0.000
H72.8 Other perforations of tympanic membrane	0.000	0.995	0.005
M24.75 Protrusio acetabuli-Pelvic/thigh	0.004	0.995	0.000
Q23.1 Congenital insufficiency of aortic valve	0.005	0.995	0.000
M24.01 Loose body in joint (Shoulder region)	0.004	0.995	0.000
M24.02 Loose body in joint (Upper arm)	0.004	0.996	0.000
D47.4 Osteomyelofibrosis	0.000	0.996	0.004
K81.0 Acute cholecystitis	0.004	0.996	0.000
I70.10 Atherosclerosis of renal artery (without gangrene)	0.004	0.996	0.000
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified	0.000	0.996	0.004
I77 Other disorders of arteries and arterioles	0.004	0.996	0.000
Q23 Congenital malformations of aortic and mitral valves	0.004	0.996	0.000
S22.40 Multiple fractures of ribs (closed)	0.004	0.996	0.000
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.000	0.996	0.004
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]	0.000	0.996	0.004
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour	0.000	0.996	0.004
Q23.0 Congenital stenosis of aortic valve	0.004	0.996	0.000
I77.9 Disorder of arteries and arterioles, unspecified	0.004	0.996	0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.004	0.996	0.000
I74.5 Embolism and thrombosis of iliac artery	0.004	0.996	0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.004	0.996	0.000
I79.1 Aortitis in diseases classified elsewhere	0.004	0.996	0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.004	0.996	0.000
Z45.0 Adjustment and management of cardiac pacemaker	0.000	0.996	0.004
I74 Arterial embolism and thrombosis	0.004	0.996	0.000
S22.50 Flail chest (closed)	0.004	0.996	0.000
I72 Other aneurysm	0.004	0.996	0.000
D05.0 Lobular carcinoma in situ	0.000	0.996	0.003
I49.4 Other and unspecified premature depolarisation	0.000	0.997	0.003
I77.1 Stricture of artery	0.003	0.997	0.000
N18.4 Chronic kidney disease, stage 4	0.000	0.997	0.003
N81.5 Vaginal enterocele	0.003	0.997	0.000
C02.9 Tongue, unspecified	0.000	0.997	0.003
S22.4 Multiple fractures of ribs	0.003	0.997	0.000
R81 Glycosuria	0.000	0.997	0.003
I77.5 Necrosis of artery	0.003	0.997	0.000
I77.4 Coeliac artery compression syndrome	0.003	0.997	0.000
I77.3 Arterial fibromuscular dysplasia	0.003	0.997	0.000
I49.1 Atrial premature depolarisation	0.000	0.997	0.003
Q23.9 Congenital malformation of aortic and mitral valves, unspecified	0.003	0.997	0.000
Q23.8 Other congenital malformations of aortic and mitral valves	0.003	0.997	0.000
Q23.4 Hypoplastic left heart syndrome	0.003	0.997	0.000
Q23.3 Congenital mitral insufficiency	0.003	0.997	0.000
Q23.2 Congenital mitral stenosis	0.003	0.997	0.000
D47.1 Chronic myeloproliferative disease	0.000	0.997	0.003
S22.5 Flail chest	0.003	0.997	0.000
G57.8 Other mononeuropathies of lower limb	0.003	0.997	0.000
I72.3 Aneurysm of iliac artery	0.003	0.997	0.000
Q38.7 Pharyngeal pouch	0.003	0.997	0.000
I77.6 Arteritis, unspecified	0.003	0.997	0.000
Q27.3 Peripheral arteriovenous malformation	0.003	0.997	0.000
Q27 Other congenital malformations of peripheral vascular system	0.003	0.997	0.000
E28.2 Polycystic ovarian syndrome	0.003	0.997	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.003	0.997	0.000
I08 Multiple valve diseases	0.003	0.997	0.000
I72.2 Aneurysm of renal artery	0.003	0.997	0.000
I08.8 Other multiple valve diseases	0.003	0.997	0.000
I08.0 Disorders of both mitral and aortic valves	0.003	0.997	0.000
K60.3 Anal fistula	0.003	0.997	0.000
S93.1 Dislocation of toe(s)	0.003	0.997	0.000
I77.2 Rupture of artery	0.003	0.997	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.003	0.997	0.000
S70.9 Superficial injury of hip and thigh, unspecified	0.000	0.997	0.003
I74.0 Embolism and thrombosis of abdominal aorta	0.003	0.997	0.000
M80 Osteoporosis with pathological fracture	0.000	0.997	0.003
Q50.4 Embryonic cyst of Fallopian tube	0.003	0.997	0.000
I71 Aortic aneurysm and dissection	0.003	0.997	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.003	0.997	0.000
I77.0 Arteriovenous fistula, acquired	0.003	0.997	0.000
I72.6 Aneurysm and dissection of vertebral artery	0.003	0.997	0.000
I72.5 Aneurysm and dissection of other precerebral arteries	0.003	0.997	0.000
I72.1 Aneurysm of artery of upper extremity	0.003	0.997	0.000
I72.8 Aneurysm of other specified arteries	0.003	0.997	0.000
Q07.0 Arnold-Chiari syndrome	0.003	0.997	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.003	0.997	0.000
S22 Fracture of rib(s), sternum and thoracic spine	0.003	0.997	0.000
I73 Other peripheral vascular diseases	0.003	0.997	0.000
K82.4 Cholesterolosis of gallbladder	0.000	0.997	0.003
K75.4 Autoimmune hepatitis	0.003	0.997	0.000
Q07 Other congenital malformations of nervous system	0.003	0.997	0.000
S22.41 Multiple fractures of ribs (open)	0.002	0.997	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.002	0.997	0.000
R47.1 Dysarthria and anarthria	0.000	0.997	0.003
S30.9 Superficial injury of abdomen, lower back and pelvis, part unspecified	0.003	0.997	0.000
Q27.8 Other specified congenital malformations of peripheral vascular system	0.002	0.997	0.000
N23 Unspecified renal colic	0.003	0.997	0.000
S22.0 Fracture of thoracic vertebra	0.003	0.997	0.000
S69.9 Unspecified injury of wrist and hand	0.000	0.997	0.003
Q38-Q45 Other congenital malformations of the digestive system	0.003	0.997	0.000
Q00-Q07 Congenital malformations of the nervous system	0.003	0.997	0.000
I72.9 Aneurysm of unspecified site	0.002	0.997	0.000
Q27.9 Congenital malformation of peripheral vascular system, unspecified	0.002	0.997	0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.002	0.997	0.000
I74.8 Embolism and thrombosis of other arteries	0.002	0.997	0.000
E04.1 Non-toxic single thyroid nodule	0.003	0.997	0.000
Q66.8 Other congenital deformities of feet	0.002	0.997	0.000
H46 Optic neuritis	0.003	0.997	0.000
S22.51 Flail chest (open)	0.002	0.997	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.000	0.997	0.002
S22.00 Fracture of thoracic vertebra (closed)	0.002	0.997	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.003	0.997	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.002	0.997	0.000
C02 Malignant neoplasm of other and unspecified parts of tongue	0.000	0.997	0.002
Q25 Congenital malformations of great arteries	0.002	0.997	0.000
Q66 Congenital deformities of feet	0.002	0.997	0.000
Q27.4 Congenital phlebectasia	0.002	0.998	0.000
Q27.2 Other congenital malformations of renal artery	0.002	0.998	0.000
Q27.1 Congenital renal artery stenosis	0.002	0.998	0.000
Q27.0 Congenital absence and hypoplasia of umbilical artery	0.002	0.998	0.000
I08.9 Multiple valve disease, unspecified	0.002	0.998	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.002	0.998	0.000
Z92.2 Personal history of long-term (current) use of other medicaments	0.000	0.998	0.002
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.002	0.998	0.000
I72.4 Aneurysm of artery of lower extremity	0.002	0.998	0.000
Q43.1 Hirschsprung's disease	0.002	0.998	0.000
Q26 Congenital malformations of great veins	0.002	0.998	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.002	0.998	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.002	0.998	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.000	0.998	0.002
S70.0 Contusion of hip	0.000	0.998	0.002
Y54.3 Benzothiadiazine derivatives	0.002	0.998	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.002	0.998	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.002	0.998	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.002	0.998	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.000	0.998	0.002
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.000	0.998	0.002
M80.2 Osteoporosis of disuse with pathological fracture	0.000	0.998	0.002
I71.0 Dissection of aorta [any part]	0.002	0.998	0.000
M80.8 Other osteoporosis with pathological fracture	0.000	0.998	0.002
Q50-Q56 Congenital malformations of genital organs	0.002	0.998	0.000
D48.0 Bone and articular cartilage	0.000	0.998	0.002
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level	0.000	0.998	0.002
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.002	0.998	0.000
Q38.8 Other congenital malformations of pharynx	0.002	0.998	0.000
Q38.6 Other congenital malformations of mouth	0.002	0.998	0.000
Q38.5 Congenital malformations of palate, not elsewhere classified	0.002	0.998	0.000
Q38.4 Congenital malformations of salivary glands and ducts	0.002	0.998	0.000
Q38.3 Other congenital malformations of tongue	0.002	0.998	0.000
Q38.2 Macroglossia	0.002	0.998	0.000
Q38.1 Ankyloglossia	0.002	0.998	0.000
Q38.0 Congenital malformations of lips, not elsewhere classified	0.002	0.998	0.000
Q40 Other congenital malformations of upper alimentary tract	0.002	0.998	0.000
S70 Superficial injury of hip and thigh	0.000	0.998	0.002
Q05 Spina bifida	0.002	0.998	0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.002	0.998	0.000
W29 Contact with other powered hand tools and household machinery	0.000	0.998	0.002
I42.8 Other cardiomyopathies	0.002	0.998	0.000
Z35 Supervision of high-risk pregnancy	0.002	0.998	0.000
S27.20 Traumatic haemopneumothorax (without open wound into thoracic cavity)	0.002	0.998	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.002	0.998	0.000
I73.8 Other specified peripheral vascular diseases	0.002	0.998	0.000
S22.9 Fracture of bony thorax, part unspecified	0.002	0.998	0.000
S22.8 Fracture of other parts of bony thorax	0.002	0.998	0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.002
I73.1 Thromboangiitis obliterans [Buerger]	0.002	0.998	0.000
Q25.3 Stenosis of aorta	0.002	0.998	0.000
Q66.7 Pes cavus	0.002	0.998	0.000
S22.1 Multiple fractures of thoracic spine	0.002	0.998	0.000
Q66.3 Other congenital varus deformities of feet	0.002	0.998	0.000
Q07.9 Congenital malformation of nervous system, unspecified	0.002	0.998	0.000
Q07.8 Other specified congenital malformations of nervous system	0.002	0.998	0.000
Q45 Other congenital malformations of digestive system	0.002	0.998	0.000
S52.80 Fracture of other parts of forearm (closed)	0.002	0.998	0.000
D09.0 Bladder	0.000	0.998	0.002
M89.37 Hypertrophy of bone (Ankle and foot)	0.002	0.998	0.000
Q05.4 Unspecified spina bifida with hydrocephalus	0.002	0.998	0.000
S22.01 Fracture of thoracic vertebra (open)	0.002	0.998	0.000
C02.1 Border of tongue	0.000	0.998	0.002
C14.0 Pharynx, unspecified	0.000	0.998	0.002
C01 Malignant neoplasm of base of tongue	0.000	0.998	0.002
Q06 Other congenital malformations of spinal cord	0.002	0.998	0.000
Q04 Other congenital malformations of brain	0.002	0.998	0.000
Q03 Congenital hydrocephalus	0.002	0.998	0.000
Q01 Encephalocele	0.002	0.998	0.000
Q00 Anencephaly and similar malformations	0.002	0.998	0.000
Q02 Microcephaly	0.002	0.998	0.000
Q42 Congenital absence, atresia and stenosis of large intestine	0.002	0.998	0.000
Q41 Congenital absence, atresia and stenosis of small intestine	0.002	0.998	0.000
Q40.3 Congenital malformation of stomach, unspecified	0.002	0.998	0.000
Q50.6 Other congenital malformatons of Fallopian tube and broad ligament	0.002	0.998	0.000
Q50.5 Embryonic cyst of broad ligament	0.002	0.998	0.000
Q50.3 Other congenital malformations of ovary	0.002	0.998	0.000
Q50.2 Congenital torsion of ovary	0.002	0.998	0.000
Q50.1 Developmental ovarian cyst	0.002	0.998	0.000
Q50.0 Congenital absence of ovary	0.002	0.998	0.000
Q70 Syndactyly	0.002	0.998	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.002	0.998	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.002	0.998	0.000
Q35-Q37 Cleft lip and cleft palate	0.002	0.998	0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
Q53 Undescended testicle	0.002	0.998	0.000
C02.8 Overlapping lesion of tongue	0.000	0.998	0.002
C02.4 Lingual tonsil	0.000	0.998	0.002
C02.3 Anterior two-thirds of tongue, part unspecified	0.000	0.998	0.002
C02.2 Ventral surface of tongue	0.000	0.998	0.002
C02.0 Dorsal surface of tongue	0.000	0.998	0.002
Q25.9 Congenital malformation of great arteries, unspecified	0.002	0.998	0.000
Q25.8 Other congenital malformations of great arteries	0.002	0.998	0.000
Q25.7 Other congenital malformations of pulmonary artery	0.002	0.998	0.000
Q25.6 Stenosis of pulmonary artery	0.002	0.998	0.000
Q25.5 Atresia of pulmonary artery	0.002	0.998	0.000
Q25.4 Other congenital malformations of aorta	0.002	0.998	0.000
Q25.2 Atresia of aorta	0.002	0.998	0.000
Q25.0 Patent ductus arteriosus	0.002	0.998	0.000
Q66.9 Congenital deformity of feet, unspecified	0.002	0.998	0.000
Q66.6 Other congenital valgus deformities of feet	0.002	0.998	0.000
Q66.5 Congenital pes planus	0.002	0.998	0.000
Q66.4 Talipes calcaneovalgus	0.002	0.998	0.000
Q66.1 Talipes calcaneovarus	0.002	0.998	0.000
Q66.0 Talipes equinovarus	0.002	0.998	0.000
S69 Other and unspecified injuries of wrist and hand	0.000	0.998	0.002
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
I72.0 Aneurysm of carotid artery	0.002	0.998	0.000
M80.0 Postmenopausal osteoporosis with pathological fracture	0.000	0.998	0.002
S70.1 Contusion of thigh	0.000	0.998	0.002
Z35.9 Supervision of high-risk pregnancy, unspecified	0.002	0.998	0.000
Q24 Other congenital malformations of heart	0.002	0.998	0.000
Q43 Other congenital malformations of intestine	0.002	0.998	0.000
Q51 Congenital malformations of uterus and cervix	0.002	0.998	0.000
F81.9 Developmental disorder of scholastic skills, unspecified	0.000	0.998	0.002
I77.8 Other specified disorders of arteries and arterioles	0.002	0.998	0.000
Q25.1 Coarctation of aorta	0.002	0.998	0.000
Q66.2 Metatarsus varus	0.002	0.998	0.000
Q20.9 Congenital malformation of cardiac chambers and connexions, unspecified	0.002	0.998	0.000
Q20.8 Other congenital malformations of cardiac chambers and connexions	0.002	0.998	0.000
Q20.6 Isomerism of atrial appendages	0.002	0.998	0.000
Q20.5 Discordant atrioventricular connexion	0.002	0.998	0.000
Q20.4 Double inlet ventricle	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations