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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs644435
log Bayes Factor = 0.325142
Chromosome 18   position 355,944  (GRCh37) Explore rs644435 on Ensembl!
Variant rs644435 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I51.8 Other ill-defined heart diseases
0.484 0.516 0.000
I51 Complications and ill-defined descriptions of heart disease
0.380 0.620 0.000
I51.4 Myocarditis, unspecified
0.364 0.636 0.000
I51.6 Cardiovascular disease, unspecified
0.322 0.678 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.316 0.684 0.000
I51.5 Myocardial degeneration
0.277 0.723 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.273 0.727 0.000
I51.0 Cardiac septal defect, acquired
0.260 0.740 0.000
I51.7 Cardiomegaly
0.223 0.777 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.216 0.783 0.000
I51.9 Heart disease, unspecified
0.202 0.798 0.000
O42.9 Premature rupture of membranes, unspecified
0.000 0.902 0.098
O42.0 Premature rupture of membranes, onset of labour within 24 hours
0.000 0.903 0.097
O42 Premature rupture of membranes
0.000 0.904 0.096
O42.1 Premature rupture of membranes, onset of labour after 24 hours
0.000 0.914 0.086
Y85.0 Sequelae of motor-vehicle accident
0.083 0.917 0.000
O42.2 Premature rupture of membranes, labour delayed by therapy
0.000 0.931 0.069
Y85 Sequelae of transport accidents
0.046 0.954 0.000
E83.5 Disorders of calcium metabolism
0.044 0.956 0.000
Y85.9 Sequelae of other and unspecified transport accidents
0.034 0.966 0.000
Q61.3 Polycystic kidney, unspecified
0.000 0.966 0.034
Q61 Cystic kidney disease
0.000 0.968 0.032
Q61.2 Polycystic kidney, adult type
0.000 0.969 0.031
Q61.0 Congenital single renal cyst
0.000 0.973 0.027
Q21.1 Atrial septal defect
0.000 0.975 0.025
Q60-Q64 Congenital malformations of the urinary system
0.000 0.975 0.025
Q61.5 Medullary cystic kidney
0.000 0.976 0.024
Q20-Q28 Congenital malformations of the circulatory system
0.000 0.976 0.024
Q21 Congenital malformations of cardiac septa
0.000 0.976 0.024
Q61.8 Other cystic kidney diseases
0.000 0.977 0.023
Q61.4 Renal dysplasia
0.000 0.977 0.023
Q61.1 Polycystic kidney, infantile type
0.000 0.977 0.023
E83 Disorders of mineral metabolism
0.023 0.977 0.000
Q24 Other congenital malformations of heart
0.000 0.977 0.023
Q61.9 Cystic kidney disease, unspecified
0.000 0.978 0.022
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.979 0.021
E83.3 Disorders of phosphorus metabolism
0.021 0.979 0.000
Q24.9 Congenital malformation of the heart, unspecified
0.000 0.979 0.021
Q23 Congenital malformations of aortic and mitral valves
0.000 0.980 0.020
Q24.5 Malformation of coronary vessels
0.000 0.980 0.020
Q27 Other congenital malformations of peripheral vascular system
0.000 0.981 0.019
Q60 Renal agenesis and other reduction defects of kidney
0.000 0.981 0.019
S91.3 Open wound of other parts of foot
0.000 0.981 0.019
Q21.3 Tetralogy of Fallot
0.000 0.981 0.019
Q80-Q89 Other congenital malformations
0.000 0.982 0.018
Q24.8 Other specified congenital malformations of heart
0.000 0.982 0.018
Q22 Congenital malformations of pulmonary and tricuspid valves
0.000 0.982 0.018
Q26 Congenital malformations of great veins
0.000 0.982 0.018
Q20 Congenital malformations of cardiac chambers and connexions
0.000 0.982 0.018
O04.9 Complete or unspecified, without complication
0.018 0.982 0.000
Q23.0 Congenital stenosis of aortic valve
0.000 0.983 0.017
Q27.8 Other specified congenital malformations of peripheral vascular system
0.000 0.983 0.017
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.000 0.983 0.017
Q21.4 Aortopulmonary septal defect
0.000 0.983 0.017
Q21.2 Atrioventricular septal defect
0.000 0.983 0.017
S91 Open wound of ankle and foot
0.000 0.983 0.017
E83.9 Disorder of mineral metabolism, unspecified
0.017 0.983 0.000
E83.8 Other disorders of mineral metabolism
0.017 0.983 0.000
E83.2 Disorders of zinc metabolism
0.017 0.983 0.000
E83.0 Disorders of copper metabolism
0.017 0.983 0.000
Q24.6 Congenital heart block
0.000 0.983 0.017
Q24.4 Congenital subaortic stenosis
0.000 0.983 0.017
Q24.3 Pulmonary infundibular stenosis
0.000 0.983 0.017
Q24.2 Cor triatriatum
0.000 0.983 0.017
Q24.1 Levocardia
0.000 0.983 0.017
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.000 0.983 0.017
Q24.0 Dextrocardia
0.000 0.983 0.017
E83.1 Disorders of iron metabolism
0.017 0.983 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.000 0.984 0.016
Z91.5 Personal history of self-harm
0.000 0.984 0.016
Q60.2 Renal agenesis, unspecified
0.000 0.984 0.016
S90-S99 Injuries to the ankle and foot
0.000 0.984 0.016
Q85 Phakomatoses, not elsewhere classified
0.000 0.984 0.016
Q21.9 Congenital malformation of cardiac septum, unspecified
0.000 0.984 0.016
Q64 Other congenital malformations of urinary system
0.000 0.984 0.016
Q21.8 Other congenital malformations of cardiac septa
0.000 0.984 0.016
Q38-Q45 Other congenital malformations of the digestive system
0.000 0.984 0.016
O04 Medical abortion
0.015 0.985 0.000
Q63 Other congenital malformations of kidney
0.000 0.985 0.015
S90 Superficial injury of ankle and foot
0.000 0.985 0.015
Q28 Other congenital malformations of circulatory system
0.000 0.985 0.015
O04.4 Incomplete, without complication
0.015 0.985 0.000
Q25 Congenital malformations of great arteries
0.000 0.985 0.015
Q23.1 Congenital insufficiency of aortic valve
0.000 0.985 0.015
Q85.0 Neurofibromatosis (nonmalignant)
0.000 0.985 0.015
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.015 0.985 0.000
S92 Fracture of foot, except ankle
0.000 0.985 0.015
Q23.9 Congenital malformation of aortic and mitral valves, unspecified
0.000 0.985 0.015
Q23.8 Other congenital malformations of aortic and mitral valves
0.000 0.985 0.015
Q23.4 Hypoplastic left heart syndrome
0.000 0.985 0.015
Q23.3 Congenital mitral insufficiency
0.000 0.985 0.015
Q23.2 Congenital mitral stenosis
0.000 0.985 0.015
Q21.0 Ventricular septal defect
0.000 0.985 0.015
Q43 Other congenital malformations of intestine
0.000 0.985 0.015
Q82 Other congenital malformations of skin
0.000 0.985 0.015
Q30-Q34 Congenital malformations of the respiratory system
0.000 0.985 0.015
Q83 Congenital malformations of breast
0.000 0.985 0.015
Q96 Turner's syndrome
0.000 0.986 0.014
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit
0.000 0.986 0.014
Q27.4 Congenital phlebectasia
0.000 0.986 0.014
Q27.2 Other congenital malformations of renal artery
0.000 0.986 0.014
Q27.1 Congenital renal artery stenosis
0.000 0.986 0.014
Q27.0 Congenital absence and hypoplasia of umbilical artery
0.000 0.986 0.014
Q35-Q37 Cleft lip and cleft palate
0.000 0.986 0.014
S90.9 Superficial injury of ankle and foot, unspecified
0.000 0.986 0.014
Q60.6 Potter's syndrome
0.000 0.986 0.014
Q60.5 Renal hypoplasia, unspecified
0.000 0.986 0.014
Q60.4 Renal hypoplasia, bilateral
0.000 0.986 0.014
Q60.3 Renal hypoplasia, unilateral
0.000 0.986 0.014
Q60.1 Renal agenesis, bilateral
0.000 0.986 0.014
S92.2 Fracture of other tarsal bone(s)
0.000 0.986 0.014
Q27.9 Congenital malformation of peripheral vascular system, unspecified
0.000 0.986 0.014
S92.3 Fracture of metatarsal bone
0.000 0.986 0.014
S91.0 Open wound of ankle
0.000 0.986 0.014
Q90 Down's syndrome
0.000 0.986 0.014
O04.8 Complete or unspecified, with other and unspecified complications
0.013 0.986 0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified
0.000 0.987 0.013
Q84 Other congenital malformations of integument
0.000 0.987 0.013
Q81 Epidermolysis bullosa
0.000 0.987 0.013
Q80 Congenital ichthyosis
0.000 0.987 0.013
Q60.0 Renal agenesis, unilateral
0.000 0.987 0.013
Q43.0 Meckel's diverticulum
0.000 0.987 0.013
Y88 Sequelae of surgical and medical care as external cause
0.013 0.987 0.000
Q22.1 Congenital pulmonary valve stenosis
0.000 0.987 0.013
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.000 0.987 0.013
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.000 0.987 0.013
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.000 0.987 0.013
S92.20 Fracture of other tarsal bone(s) (closed)
0.000 0.987 0.013
S90.8 Other superficial injuries of ankle and foot
0.000 0.987 0.013
Q22.9 Congenital malformation of tricuspid valve, unspecified
0.000 0.987 0.013
Q22.8 Other congenital malformations of tricuspid valve
0.000 0.987 0.013
Q22.6 Hypoplastic right heart syndrome
0.000 0.987 0.013
Q22.5 Ebstein's anomaly
0.000 0.987 0.013
Q22.4 Congenital tricuspid stenosis
0.000 0.987 0.013
Q22.3 Other congenital malformations of pulmonary valve
0.000 0.987 0.013
Q22.2 Congenital pulmonary valve insufficiency
0.000 0.987 0.013
Q22.0 Pulmonary valve atresia
0.000 0.987 0.013
Q17 Other congenital malformations of ear
0.000 0.987 0.013
Q20.9 Congenital malformation of cardiac chambers and connexions, unspecified
0.000 0.987 0.013
Q20.8 Other congenital malformations of cardiac chambers and connexions
0.000 0.987 0.013
Q20.6 Isomerism of atrial appendages
0.000 0.987 0.013
Q20.5 Discordant atrioventricular connexion
0.000 0.987 0.013
Q20.4 Double inlet ventricle
0.000 0.987 0.013
Q20.3 Discordant ventriculoarterial connexion
0.000 0.987 0.013
Q20.2 Double outlet left ventricle
0.000 0.987 0.013
Q20.1 Double outlet right ventricle
0.000 0.987 0.013
Q20.0 Common arterial trunk
0.000 0.987 0.013
Q26.9 Congenital malformation of great vein, unspecified
0.000 0.987 0.013
Q26.8 Other congenital malformations of great veins
0.000 0.987 0.013
Q26.6 Portal vein-hepatic artery fistula
0.000 0.987 0.013
Q26.5 Anomalous portal venous connexion
0.000 0.987 0.013
Q26.4 Anomalous pulmonary venous connexion, unspecified
0.000 0.987 0.013
Q26.3 Partial anomalous pulmonary venous connexion
0.000 0.987 0.013
Q26.2 Total anomalous pulmonary venous connexion
0.000 0.987 0.013
Q26.1 Persistent left superior vena cava
0.000 0.987 0.013
Q26.0 Congenital stenosis of vena cava
0.000 0.987 0.013
Q15 Other congenital malformations of eye
0.000 0.987 0.013
S92.30 Fracture of metatarsal bone (closed)
0.000 0.987 0.013
Q82.5 Congenital nonneoplastic naevus
0.000 0.987 0.013
S99 Other and unspecified injuries of ankle and foot
0.000 0.987 0.013
Q43.9 Congenital malformation of intestine, unspecified
0.000 0.987 0.013
Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified
0.000 0.987 0.012
Q95 Balanced rearrangements and structural markers, not elsewhere classified
0.000 0.987 0.012
Q93 Monosomies and deletions from the autosomes, not elsewhere classified
0.000 0.987 0.012
Q92 Other trisomies and partial trisomies of the autosomes, not elsewhere classified
0.000 0.987 0.012
Q91 Edwards' syndrome and Patau's syndrome
0.000 0.987 0.012
S91.7 Multiple open wounds of ankle and foot
0.000 0.987 0.013
Q43.3 Congenital malformations of intestinal fixation
0.000 0.987 0.012
S97 Crushing injury of ankle and foot
0.000 0.987 0.012
Q10.0 Congenital ptosis
0.000 0.987 0.012
Q11 Anophthalmos, microphthalmos and macrophthalmos
0.000 0.988 0.012
Q16 Congenital malformations of ear causing impairment of hearing
0.000 0.988 0.012
Q13 Congenital malformations of anterior segment of eye
0.000 0.988 0.012
Q25.1 Coarctation of aorta
0.000 0.988 0.012
Q96.9 Turner's syndrome, unspecified
0.000 0.988 0.012
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure
0.012 0.988 0.000
Q18 Other congenital malformations of face and neck
0.000 0.988 0.012
Q27.3 Peripheral arteriovenous malformation
0.000 0.988 0.012
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified
0.000 0.988 0.012
S91.1 Open wound of toe(s) without damage to nail
0.000 0.988 0.012
Q99 Other chromosome abnormalities, not elsewhere classified
0.000 0.988 0.012
Q62.8 Other congenital malformations of ureter
0.000 0.988 0.012
Q62.7 Congenital vesico-uretero-renal reflux
0.000 0.988 0.012
Q62.6 Malposition of ureter
0.000 0.988 0.012
Q62.4 Agenesis of ureter
0.000 0.988 0.012
Q62.3 Other obstructive defects of renal pelvis and ureter
0.000 0.988 0.012
Q62.2 Congenital megaloureter
0.000 0.988 0.012
Q62.1 Atresia and stenosis of ureter
0.000 0.988 0.012
Q62.0 Congenital hydronephrosis
0.000 0.988 0.012
S92.4 Fracture of great toe
0.000 0.988 0.012
Q00-Q07 Congenital malformations of the nervous system
0.000 0.988 0.012
Q28.0 Arteriovenous malformation of precerebral vessels
0.000 0.988 0.012
Q63.2 Ectopic kidney
0.000 0.988 0.012
S95 Injury of blood vessels at ankle and foot level
0.000 0.988 0.012
S94 Injury of nerves at ankle and foot level
0.000 0.988 0.012
Q85.1 Tuberous sclerosis
0.000 0.988 0.012
Q64.9 Congenital malformation of urinary system, unspecified
0.000 0.988 0.011
Q64.8 Other specified congenital malformations of urinary system
0.000 0.988 0.011
Q64.6 Congenital diverticulum of bladder
0.000 0.988 0.011
Q64.5 Congenital absence of bladder and urethra
0.000 0.988 0.011
Q64.4 Malformation of urachus
0.000 0.988 0.011
Q64.2 Congenital posterior urethral valves
0.000 0.988 0.011
Q64.1 Exstrophy of urinary bladder
0.000 0.988 0.011
Q64.0 Epispadias
0.000 0.988 0.011
Q85.9 Phakomatosis, unspecified
0.000 0.988 0.011
S90.0 Contusion of ankle
0.000 0.988 0.011
S91.2 Open wound of toe(s) with damage to nail
0.000 0.988 0.011
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.000 0.988 0.012
Q83.8 Other congenital malformations of breast
0.000 0.988 0.011
Q42 Congenital absence, atresia and stenosis of large intestine
0.000 0.988 0.011
Q41 Congenital absence, atresia and stenosis of small intestine
0.000 0.988 0.011
Q14 Congenital malformations of posterior segment of eye
0.000 0.989 0.011
Q64.3 Other atresia and stenosis of urethra and bladder neck
0.000 0.989 0.011
Q44.6 Cystic disease of liver
0.000 0.989 0.011
O04.7 Complete or unspecified, complicated by embolism
0.011 0.989 0.000
O04.6 Complete or unspecified, complicated by delayed or excessive haemorrhage
0.011 0.989 0.000
O04.5 Complete or unspecified, complicated by genital tract and pelvic infection
0.011 0.989 0.000
O04.3 Incomplete, with other and unspecified complications
0.011 0.989 0.000
O04.2 Incomplete, complicated by embolism
0.011 0.989 0.000
O04.0 Incomplete, complicated by genital tract and pelvic infection
0.011 0.989 0.000
Q63.9 Congenital malformation of kidney, unspecified
0.000 0.989 0.011
Q63.8 Other specified congenital malformations of kidney
0.000 0.989 0.011
Q63.3 Hyperplastic and giant kidney
0.000 0.989 0.011
Q12 Congenital lens malformations
0.000 0.989 0.011
S80.9 Superficial injury of lower leg, unspecified
0.000 0.989 0.011
S90.7 Multiple superficial injuries of ankle and foot
0.000 0.989 0.011
S90.2 Contusion of toe(s) with damage to nail
0.000 0.989 0.011
Q89 Other congenital malformations, not elsewhere classified
0.000 0.989 0.011
Q28.9 Congenital malformation of circulatory system, unspecified
0.000 0.989 0.011
Q28.8 Other specified congenital malformations of circulatory system
0.000 0.989 0.011
Q28.1 Other malformations of precerebral vessels
0.000 0.989 0.011
S92.7 Multiple fractures of foot
0.000 0.989 0.011
S90.3 Contusion of other and unspecified parts of foot
0.000 0.989 0.011
Q25.9 Congenital malformation of great arteries, unspecified
0.000 0.989 0.011
Q25.8 Other congenital malformations of great arteries
0.000 0.989 0.011
Q25.7 Other congenital malformations of pulmonary artery
0.000 0.989 0.011
Q25.5 Atresia of pulmonary artery
0.000 0.989 0.011
Q25.3 Stenosis of aorta
0.000 0.989 0.011
Q25.2 Atresia of aorta
0.000 0.989 0.011
Q83.1 Accessory breast
0.000 0.989 0.011
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.011 0.989 0.000
Q40 Other congenital malformations of upper alimentary tract
0.000 0.989 0.011
S92.9 Fracture of foot, unspecified
0.000 0.989 0.011
Q63.1 Lobulated, fused and horseshoe kidney
0.000 0.989 0.011
Q90.9 Down's syndrome, unspecified
0.000 0.989 0.011
Q43.7 Persistent cloaca
0.000 0.989 0.011
Q43.6 Congenital fistula of rectum and anus
0.000 0.989 0.011
Q43.5 Ectopic anus
0.000 0.989 0.011
Q43.4 Duplication of intestine
0.000 0.989 0.011
Q43.2 Other congenital functional disorders of colon
0.000 0.989 0.011
Q34 Other congenital malformations of respiratory system
0.000 0.989 0.011
Q33 Congenital malformations of lung
0.000 0.989 0.011
Q32 Congenital malformations of trachea and bronchus
0.000 0.989 0.011
Q82.9 Congenital malformation of skin, unspecified
0.000 0.989 0.011
Q82.4 Ectodermal dysplasia (anhidrotic)
0.000 0.989 0.011
Q82.3 Incontinentia pigmenti
0.000 0.989 0.011
Q82.1 Xeroderma pigmentosum
0.000 0.989 0.011
Q82.0 Hereditary lymphoedema
0.000 0.989 0.011
Q25.6 Stenosis of pulmonary artery
0.000 0.989 0.010
Q83.9 Congenital malformation of breast, unspecified
0.000 0.989 0.011
Q83.3 Accessory nipple
0.000 0.989 0.011
Q83.2 Absent nipple
0.000 0.989 0.011
Q83.0 Congenital absence of breast with absent nipple
0.000 0.989 0.011
S96 Injury of muscle and tendon at ankle and foot level
0.000 0.989 0.011
S92.40 Fracture of great toe (closed)
0.000 0.989 0.011
Q62.5 Duplication of ureter
0.000 0.989 0.010
S98 Traumatic amputation of ankle and foot
0.000 0.989 0.010
Q96.8 Other variants of Turner's syndrome
0.000 0.989 0.010
Q96.4 Mosaicism, 45,X/other cell line(s) with abnormal sex chromosome
0.000 0.989 0.010
Q96.3 Mosaicism, 45,X/46,XX or XY
0.000 0.989 0.010
Q96.2 Karyotype 46,X with abnormal sex chromosome, except iso (Xq)
0.000 0.989 0.010
Q96.1 Karyotype 46,X iso (Xq)
0.000 0.989 0.010
Q96.0 Karyotype 45,X
0.000 0.989 0.010
Q50-Q56 Congenital malformations of genital organs
0.000 0.989 0.011
Q10.7 Congenital malformation of orbit
0.000 0.989 0.010
Q10.6 Other congenital malformations of lachrymal apparatus
0.000 0.989 0.010
Q10.5 Congenital stenosis and stricture of lachrymal duct
0.000 0.989 0.010
Q10.4 Absence and agenesis of lachrymal apparatus
0.000 0.989 0.010
Q10.3 Other congenital malformations of eyelid
0.000 0.989 0.010
Q10.2 Congenital entropion
0.000 0.989 0.010
Q10.1 Congenital ectropion
0.000 0.989 0.010
Q43.1 Hirschsprung's disease
0.000 0.989 0.010
Q31 Congenital malformations of larynx
0.000 0.989 0.010
Q18.1 Preauricular sinus and cyst
0.000 0.989 0.010
S93.1 Dislocation of toe(s)
0.000 0.989 0.010
Q87.0 Congenital malformation syndromes predominantly affecting facial appearance
0.000 0.990 0.010
Q36 Cleft lip
0.000 0.990 0.010
Q28.3 Other malformations of cerebral vessels
0.000 0.990 0.010
Q25.4 Other congenital malformations of aorta
0.000 0.990 0.010
E83.4 Disorders of magnesium metabolism
0.010 0.990 0.000
Q87.8 Other specified congenital malformation syndromes, not elsewhere classified
0.000 0.990 0.010
S93.3 Dislocation of other and unspecified parts of foot
0.000 0.990 0.010
O04.1 Incomplete, complicated by delayed or excessive haemorrhage
0.010 0.990 0.000
Q82.8 Other specified congenital malformations of skin
0.000 0.990 0.010
Q85.8 Other phakomatoses, not elsewhere classified
0.000 0.990 0.010
S92.21 Fracture of other tarsal bone(s) (open)
0.000 0.990 0.010
Q30 Congenital malformations of nose
0.000 0.990 0.010
S92.1 Fracture of talus
0.000 0.990 0.010
Q17.5 Prominent ear
0.000 0.990 0.010
S92.31 Fracture of metatarsal bone (open)
0.000 0.990 0.010
Q15.0 Congenital glaucoma
0.000 0.990 0.010
Q90.2 Trisomy 21, translocation
0.000 0.990 0.010
Q90.1 Trisomy 21, mosaicism (mitotic nondisjunction)
0.000 0.990 0.010
Q90.0 Trisomy 21, meiotic nondisjunction
0.000 0.990 0.010
S99.9 Unspecified injury of ankle and foot
0.000 0.990 0.010
Q82.2 Mastocytosis
0.000 0.990 0.010
S97.8 Crushing injury of other parts of ankle and foot
0.000 0.990 0.010
Q35 Cleft palate
0.000 0.990 0.010
Q64.7 Other congenital malformations of bladder and urethra
0.000 0.990 0.010
Q80.9 Congenital ichthyosis, unspecified
0.000 0.990 0.010
Q80.8 Other congenital ichthyosis
0.000 0.990 0.010
Q80.4 Harlequin foetus
0.000 0.990 0.010
Q80.3 Congenital bullous ichthyosiform erythroderma
0.000 0.990 0.010
Q80.2 Lamellar ichthyosis
0.000 0.990 0.010
Q80.1 X-linked ichthyosis
0.000 0.990 0.010
Q80.0 Ichthyosis vulgaris
0.000 0.990 0.010
Q81.9 Epidermolysis bullosa, unspecified
0.000 0.990 0.010
Q81.8 Other epidermolysis bullosa
0.000 0.990 0.010
Q81.2 Epidermolysis bullosa dystrophica
0.000 0.990 0.010
Q81.1 Epidermolysis bullosa letalis
0.000 0.990 0.010
Q81.0 Epidermolysis bullosa simplex
0.000 0.990 0.010
Q84.9 Congenital malformation of integument, unspecified
0.000 0.990 0.010
Q84.8 Other specified congenital malformations of integument
0.000 0.990 0.010
Q84.6 Other congenital malformations of nails
0.000 0.990 0.010
Q84.5 Enlarged and hypertrophic nails
0.000 0.990 0.010
Q84.4 Congenital leukonychia
0.000 0.990 0.010
Q84.3 Anonychia
0.000 0.990 0.010
Q84.2 Other congenital malformations of hair
0.000 0.990 0.010
Q84.1 Congenital morphological disturbances of hair, not elsewhere classified
0.000 0.990 0.010
Q84.0 Congenital alopecia
0.000 0.990 0.010
Q86.8 Other congenital malformation syndromes due to known exogenous causes
0.000 0.990 0.010
Q86.2 Dysmorphism due to warfarin
0.000 0.990 0.010
Q86.1 Foetal hydantoin syndrome
0.000 0.990 0.010
Q86.0 Foetal alcohol syndrome (dysmorphic)
0.000 0.990 0.010
S99.8 Other specified injuries of ankle and foot
0.000 0.990 0.010
S92.0 Fracture of calcaneus
0.000 0.990 0.010
Y88.2 Sequelae of adverse incidents associated with medical devices in diagnostic and therapeutic use
0.010 0.990 0.000
Y88.0 Sequelae of adverse effects caused by drugs, medicaments and biological substances in therapeutic use
0.010 0.990 0.000
Q45 Other congenital malformations of digestive system
0.000 0.990 0.009
Q87.5 Other congenital malformation syndromes with other skeletal changes
0.000 0.990 0.010
Q87.3 Congenital malformation syndromes involving early overgrowth
0.000 0.990 0.010
Q87.2 Congenital malformation syndromes predominantly involving limbs
0.000 0.990 0.010
Q87.1 Congenital malformation syndromes predominantly associated with short stature
0.000 0.990 0.010
Q44.7 Other congenital malformations of liver
0.000 0.990 0.009
Q44.5 Other congenital malformations of bile ducts
0.000 0.990 0.009
Q44.4 Choledochal cyst
0.000 0.990 0.009
Q44.3 Congenital stenosis and stricture of bile ducts
0.000 0.990 0.009
Q44.2 Atresia of bile ducts
0.000 0.990 0.009
Q44.1 Other congenital malformations of gallbladder
0.000 0.990 0.009
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder
0.000 0.990 0.009
S93.4 Sprain and strain of ankle
0.000 0.990 0.010
S93.6 Sprain and strain of other and unspecified parts of foot
0.000 0.990 0.010
S93.5 Sprain and strain of toe(s)
0.000 0.990 0.010
S93.2 Rupture of ligaments at ankle and foot level
0.000 0.990 0.010
S90.1 Contusion of toe(s) without damage to nail
0.000 0.990 0.009
Q37 Cleft palate with cleft lip
0.000 0.990 0.009
Q17.9 Congenital malformation of ear, unspecified
0.000 0.990 0.009
Q17.8 Other specified congenital malformations of ear
0.000 0.990 0.009
Q17.4 Misplaced ear
0.000 0.990 0.009
Q17.3 Other misshapen ear
0.000 0.990 0.009
Q17.2 Microtia
0.000 0.990 0.009
Q17.1 Macrotia
0.000 0.990 0.009
Q17.0 Accessory auricle
0.000 0.990 0.009
Q15.9 Congenital malformation of eye, unspecified
0.000 0.990 0.009
Q15.8 Other specified congenital malformations of eye
0.000 0.990 0.009
S93.0 Dislocation of ankle joint
0.000 0.990 0.009
S99.7 Multiple injuries of ankle and foot
0.000 0.991 0.009
Q91.7 Patau's syndrome, unspecified
0.000 0.991 0.009
Q91.6 Trisomy 13, translocation
0.000 0.991 0.009
Q91.5 Trisomy 13, mosaicism (mitotic nondisjunction)
0.000 0.991 0.009
Q91.4 Trisomy 13, meiotic nondisjunction
0.000 0.991 0.009
Q91.3 Edwards' syndrome, unspecified
0.000 0.991 0.009
Q91.2 Trisomy 18, translocation
0.000 0.991 0.009
Q91.1 Trisomy 18, mosaicism (mitotic nondisjunction)
0.000 0.991 0.009
Q91.0 Trisomy 18, meiotic nondisjunction
0.000 0.991 0.009
Q92.9 Trisomy and partial trisomy of autosomes, unspecified
0.000 0.991 0.009
Q92.8 Other specified trisomies and partial trisomies of autosomes
0.000 0.991 0.009
Q92.7 Triploidy and polyploidy
0.000 0.991 0.009
Q92.6 Extra marker chromosomes
0.000 0.991 0.009
Q92.5 Duplications with other complex rearrangements
0.000 0.991 0.009
Q92.4 Duplications seen only at prometaphase
0.000 0.991 0.009
Q92.3 Minor partial trisomy
0.000 0.991 0.009
Q92.2 Major partial trisomy
0.000 0.991 0.009
Q92.1 Whole chromosome trisomy, mosaicism (mitotic nondisjunction)
0.000 0.991 0.009
Q92.0 Whole chromosome trisomy, meiotic nondisjunction
0.000 0.991 0.009
Q93.9 Deletion from autosomes, unspecified
0.000 0.991 0.009
Q93.8 Other deletions from the autosomes
0.000 0.991 0.009
Q93.7 Deletions with other complex rearrangements
0.000 0.991 0.009
Q93.6 Deletions seen only at prometaphase
0.000 0.991 0.009
Q93.5 Other deletions of part of a chromosome
0.000 0.991 0.009
Q93.4 Deletion of short arm of chromosome 5
0.000 0.991 0.009
Q93.3 Deletion of short arm of chromosome 4
0.000 0.991 0.009
Q93.2 Chromosome replaced with ring or dicentric
0.000 0.991 0.009
Q93.1 Whole chromosome monosomy, mosaicism (mitotic nondisjunction)
0.000 0.991 0.009
Q93.0 Whole chromosome monosomy, meiotic nondisjunction
0.000 0.991 0.009
Q95.9 Balanced rearrangement and structural marker, unspecified
0.000 0.991 0.009
Q95.8 Other balanced rearrangements and structural markers
0.000 0.991 0.009
Q95.5 Individuals with autosomal fragile site
0.000 0.991 0.009
Q95.4 Individuals with marker heterochromatin
0.000 0.991 0.009
Q95.3 Balanced sex/autosomal rearrangement in abnormal individual
0.000 0.991 0.009
Q95.2 Balanced autosomal rearrangement in abnormal individual
0.000 0.991 0.009
Q95.1 Chromosome inversion in normal individual
0.000 0.991 0.009
Q95.0 Balanced translocation and insertion in normal individual
0.000 0.991 0.009
Q97.9 Sex chromosome abnormality, female phenotype, unspecified
0.000 0.991 0.009
Q97.8 Other specified sex chromosome abnormalities, female phenotype
0.000 0.991 0.009
Q97.3 Female with 46,XY karyotype
0.000 0.991 0.009
Q97.2 Mosaicism, lines with various numbers of X chromosomes
0.000 0.991 0.009
Q97.1 Female with more than three X chromosomes
0.000 0.991 0.009
Q97.0 Karyotype 47,XXX
0.000 0.991 0.009
Q78 Other osteochondrodysplasias
0.000 0.991 0.009
S97.1 Crushing injury of toe(s)
0.000 0.991 0.009
S97.0 Crushing injury of ankle
0.000 0.991 0.009
Q11.1 Other anophthalmos
0.000 0.991 0.009
Q11.3 Macrophthalmos
0.000 0.991 0.009
Q11.2 Microphthalmos
0.000 0.991 0.009
Q11.0 Cystic eyeball
0.000 0.991 0.009
Q13.9 Congenital malformation of anterior segment of eye, unspecified
0.000 0.991 0.009
Q13.8 Other congenital malformations of anterior segment of eye
0.000 0.991 0.009
Q13.5 Blue sclera
0.000 0.991 0.009
Q13.4 Other congenital corneal malformations
0.000 0.991 0.009
Q13.3 Congenital corneal opacity
0.000 0.991 0.009
Q13.2 Other congenital malformations of iris
0.000 0.991 0.009
Q13.1 Absence of iris
0.000 0.991 0.009
Q13.0 Coloboma of iris
0.000 0.991 0.009
Q16.9 Congenital malformation of ear causing impairment of hearing, unspecified
0.000 0.991 0.009
Q16.5 Congenital malformation of inner ear
0.000 0.991 0.009
Q16.4 Other congenital malformations of middle ear
0.000 0.991 0.009
Q16.3 Congenital malformation of ear ossicles
0.000 0.991 0.009
Q16.2 Absence of eustachian tube
0.000 0.991 0.009
Q16.1 Congenital absence, atresia and stricture of auditory canal (external)
0.000 0.991 0.009
Q16.0 Congenital absence of (ear) auricle
0.000 0.991 0.009
Q03 Congenital hydrocephalus
0.000 0.991 0.009
Y89 Sequelae of other external causes
0.009 0.991 0.000
Y88.1 Sequelae of misadventures to patients during surgical and medical procedures
0.009 0.991 0.000
Y87.1 Sequelae of assault
0.009 0.991 0.000
Q18.9 Congenital malformation of face and neck, unspecified
0.000 0.991 0.009
Q18.8 Other specified congenital malformations of face and neck
0.000 0.991 0.009
Q18.7 Microcheilia
0.000 0.991 0.009
Q18.6 Macrocheilia
0.000 0.991 0.009
Q18.5 Microstomia
0.000 0.991 0.009
Q18.4 Macrostomia
0.000 0.991 0.009
Q18.3 Webbing of neck
0.000 0.991 0.009
Q18.2 Other branchial cleft malformations
0.000 0.991 0.009
Q98.9 Sex chromosome abnormality, male phenotype, unspecified
0.000 0.991 0.009
Q98.8 Other specified sex chromosome abnormalities, male phenotype
0.000 0.991 0.009
Q98.7 Male with sex chromosome mosaicism
0.000 0.991 0.009
Q98.6 Male with structurally abnormal sex chromosome
0.000 0.991 0.009
Q98.5 Karyotype 47,XYY
0.000 0.991 0.009
Q98.3 Other male with 46,XX karyotype
0.000 0.991 0.009
Q98.2 Klinefelter's syndrome, male with 46,XX karyotype
0.000 0.991 0.009
Q98.1 Klinefelter's syndrome, male with more than two X chromosomes
0.000 0.991 0.009
Q98.0 Klinefelter's syndrome karyotype 47,XXY
0.000 0.991 0.009
Q99.9 Chromosomal abnormality, unspecified
0.000 0.991 0.009
Q99.2 Fragile X chromosome
0.000 0.991 0.009
Q99.1 46,XX true hermaphrodite
0.000 0.991 0.009
Q99.0 Chimera 46,XX/46,XY
0.000 0.991 0.009
Q06 Other congenital malformations of spinal cord
0.000 0.991 0.009
Q01 Encephalocele
0.000 0.991 0.009
Q00 Anencephaly and similar malformations
0.000 0.991 0.009
Q02 Microcephaly
0.000 0.991 0.009
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.000 0.991 0.009
S92.5 Fracture of other toe
0.000 0.991 0.009
Q04 Other congenital malformations of brain
0.000 0.991 0.009
S94.9 Injury of unspecified nerve at ankle and foot level
0.000 0.991 0.008
S94.8 Injury of other nerves at ankle and foot level
0.000 0.991 0.008
S94.7 Injury of multiple nerves at ankle and foot level
0.000 0.991 0.008
S94.3 Injury of cutaneous sensory nerve at ankle and foot level
0.000 0.991 0.008
S94.2 Injury of deep peroneal nerve at ankle and foot level
0.000 0.991 0.008
S94.1 Injury of medial plantar nerve
0.000 0.991 0.008
S94.0 Injury of lateral plantar nerve
0.000 0.991 0.008
S95.9 Injury of unspecified blood vessel at ankle and foot level
0.000 0.991 0.008
S95.8 Injury of other blood vessels at ankle and foot level
0.000 0.991 0.008
S95.7 Injury of multiple blood vessels at ankle and foot level
0.000 0.991 0.008
S95.2 Injury of dorsal vein of foot
0.000 0.991 0.008
S95.1 Injury of plantar artery of foot
0.000 0.991 0.008
S95.0 Injury of dorsal artery of foot
0.000 0.991 0.008
Q40.2 Other specified congenital malformations of stomach
0.000 0.991 0.008
Z51.0 Radiotherapy session
0.009 0.991 0.000
Q75 Other congenital malformations of skull and face bones
0.000 0.991 0.008
Q73 Reduction defects of unspecified limb
0.000 0.991 0.008
Q72 Reduction defects of lower limb
0.000 0.991 0.008
Q71 Reduction defects of upper limb
0.000 0.991 0.008
Q70 Syndactyly
0.000 0.991 0.008
Q69 Polydactyly
0.000 0.991 0.008
Q41.9 Congenital absence, atresia and stenosis of small intestine, part unspecified
0.000 0.991 0.008
Q41.8 Congenital absence, atresia and stenosis of other specified parts of small intestine
0.000 0.991 0.008
Q41.2 Congenital absence, atresia and stenosis of ileum
0.000 0.991 0.008
Q41.1 Congenital absence, atresia and stenosis of jejunum
0.000 0.991 0.008
Q41.0 Congenital absence, atresia and stenosis of duodenum
0.000 0.991 0.008
Q42.9 Congenital absence, atresia and stenosis of large intestine, part unspecified
0.000 0.991 0.008
Q42.8 Congenital absence, atresia and stenosis of other parts of large intestine
0.000 0.991 0.008
Q42.3 Congenital absence, atresia and stenosis of anus without fistula
0.000 0.991 0.008
Q42.2 Congenital absence, atresia and stenosis of anus with fistula
0.000 0.991 0.008
Q42.1 Congenital absence, atresia and stenosis of rectum without fistula
0.000 0.991 0.008
Q42.0 Congenital absence, atresia and stenosis of rectum with fistula
0.000 0.991 0.008
Q74 Other congenital malformations of limb(s)
0.000 0.991 0.008
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.000 0.992 0.008
Q14.9 Congenital malformation of posterior segment of eye, unspecified
0.000 0.992 0.008
Q14.8 Other congenital malformations of posterior segment of eye
0.000 0.992 0.008
Q14.3 Congenital malformation of choroid
0.000 0.992 0.008

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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