TreeWAS – Variant ID: rs6859

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	1.000	0.000	0.000
R41.0 Disorientation, unspecified	1.000	0.000	0.000
G30.9 Alzheimer's disease, unspecified	1.000	0.000	0.000
F00-F09 Organic, including symptomatic, mental disorders	1.000	0.000	0.000
I25.1 Atherosclerotic heart disease	1.000	0.000	0.000
F03 Unspecified dementia	1.000	0.000	0.000
F00 Dementia in Alzheimer's disease	1.000	0.000	0.000
F00.9 Dementia in Alzheimer's disease, unspecified	0.999	0.001	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.982	0.018	0.000
I25 Chronic ischaemic heart disease	0.977	0.023	0.000
E78.2 Mixed hyperlipidaemia	0.972	0.028	0.000
G30 Alzheimer's disease	0.958	0.042	0.000
I21 Acute myocardial infarction	0.952	0.048	0.000
I20-I25 Ischaemic heart diseases	0.952	0.048	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.951	0.049	0.000
F02 Dementia in other diseases classified elsewhere	0.947	0.053	0.000
I21.9 Acute myocardial infarction, unspecified	0.943	0.057	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.941	0.059	0.000
F01 Vascular dementia	0.928	0.072	0.000
G30-G32 Other degenerative diseases of the nervous system	0.884	0.116	0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.868	0.132	0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.867	0.133	0.000
F00.1 Dementia in Alzheimer's disease with late onset	0.850	0.150	0.000
F02.3 Dementia in Parkinson's disease	0.840	0.160	0.000
E78.4 Other hyperlipidaemia	0.834	0.166	0.000
E78.8 Other disorders of lipoprotein metabolism	0.832	0.168	0.000
F01.9 Vascular dementia, unspecified	0.831	0.169	0.000
F00.0 Dementia in Alzheimer's disease with early onset	0.830	0.170	0.000
I25.6 Silent myocardial ischaemia	0.826	0.174	0.000
F00.2 Dementia in Alzheimer's disease, atypical or mixed type	0.813	0.187	0.000
G31.8 Other specified degenerative diseases of nervous system	0.806	0.194	0.000
F02.8 Dementia in other specified diseases classified elsewhere	0.802	0.198	0.000
F01.1 Multi-infarct dementia	0.790	0.210	0.000
G30.0 Alzheimer's disease with early onset	0.788	0.212	0.000
F06.7 Mild cognitive disorder	0.788	0.212	0.000
F05 Delirium, not induced by alcohol and other psychoactive substances	0.783	0.217	0.000
F02.0 Dementia in Pick's disease	0.774	0.226	0.000
I20 Angina pectoris	0.773	0.227	0.000
G31.9 Degenerative disease of nervous system, unspecified	0.760	0.240	0.000
G30.1 Alzheimer's disease with late onset	0.758	0.242	0.000
R41 Other symptoms and signs involving cognitive functions and awareness	0.749	0.251	0.000
G31.0 Circumscribed brain atrophy	0.736	0.264	0.000
F06.2 Organic delusional [schizophrenia-like] disorder	0.735	0.265	0.000
I25.3 Aneurysm of heart	0.724	0.276	0.000
G30.8 Other Alzheimer's disease	0.723	0.277	0.000
E78.6 Lipoprotein deficiency	0.722	0.278	0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.717	0.283	0.000
E78.3 Hyperchylomicronaemia	0.702	0.298	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.694	0.306	0.000
F09 Unspecified organic or symptomatic mental disorder	0.690	0.310	0.000
I20.9 Angina pectoris, unspecified	0.688	0.312	0.000
R41.3 Other amnesia	0.687	0.313	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.682	0.317	0.000
F02.4 Dementia in human immunodeficiency virus [HIV] disease	0.679	0.321	0.000
F02.2 Dementia in Huntington's disease	0.679	0.321	0.000
F02.1 Dementia in Creutzfeldt-Jakob disease	0.679	0.321	0.000
F05.8 Other delirium	0.668	0.331	0.000
I23 Certain current complications following acute myocardial infarction	0.668	0.332	0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere	0.668	0.332	0.000
E78.5 Hyperlipidaemia, unspecified	0.668	0.332	0.000
I20.8 Other forms of angina pectoris	0.667	0.333	0.000
F01.8 Other vascular dementia	0.665	0.334	0.000
F01.3 Mixed cortical and subcortical vascular dementia	0.665	0.334	0.000
F01.2 Subcortical vascular dementia	0.665	0.334	0.000
F01.0 Vascular dementia of acute onset	0.665	0.334	0.000
F05.0 Delirium not superimposed on dementia, so described	0.663	0.337	0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.663	0.337	0.000
G31.2 Degeneration of nervous system due to alcohol	0.651	0.349	0.000
E78.1 Pure hyperglyceridaemia	0.637	0.363	0.000
I25.5 Ischaemic cardiomyopathy	0.629	0.371	0.000
F06.6 Organic emotionally labile [asthenic] disorder	0.623	0.377	0.000
F06.5 Organic dissociative disorder	0.623	0.377	0.000
F06.4 Organic anxiety disorder	0.623	0.377	0.000
F06.3 Organic mood [affective] disorders	0.623	0.377	0.000
F06.1 Organic catatonic disorder	0.623	0.377	0.000
F06.0 Organic hallucinosis	0.623	0.377	0.000
G31.1 Senile degeneration of brain, not elsewhere classified	0.622	0.378	0.000
R41.1 Anterograde amnesia	0.615	0.385	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.580	0.420	0.000
F06.8 Other specified mental disorders due to brain damage and dysfunction and to physical disease	0.576	0.424	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.567	0.433	0.000
F05.1 Delirium superimposed on dementia	0.561	0.439	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.558	0.442	0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness	0.555	0.445	0.000
I25.4 Coronary artery aneurysm	0.535	0.465	0.000
F07.9 Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction	0.526	0.474	0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere	0.513	0.487	0.000
I20.1 Angina pectoris with documented spasm	0.507	0.492	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.479	0.521	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.479	0.521	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.479	0.521	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.479	0.521	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.479	0.521	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.479	0.521	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.479	0.521	0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere	0.479	0.521	0.000
F07.8 Other organic personality and behavioural disorders due to brain disease, damage and dysfunction	0.475	0.525	0.000
F07.1 Postencephalitic syndrome	0.475	0.525	0.000
I24 Other acute ischaemic heart diseases	0.472	0.528	0.000
I23.8 Other current complications following acute myocardial infarction	0.464	0.535	0.000
R41.2 Retrograde amnesia	0.430	0.570	0.000
F07.0 Organic personality disorder	0.430	0.570	0.000
I21.4 Acute subendocardial myocardial infarction	0.429	0.571	0.000
F06.9 Unspecified mental disorder due to brain damage and dysfunction and to physical disease	0.422	0.578	0.001
I24.1 Dressler's syndrome	0.396	0.604	0.000
F07.2 Postconcussional syndrome	0.396	0.604	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.395	0.604	0.001
I24.8 Other forms of acute ischaemic heart disease	0.294	0.706	0.000
E70-E90 Metabolic disorders	0.293	0.707	0.000
E86 Volume depletion	0.293	0.707	0.000
E87 Other disorders of fluid, electrolyte and acid-base balance	0.260	0.740	0.000
E87.1 Hypo-osmolality and hyponatraemia	0.251	0.749	0.000
E87.0 Hyperosmolality and hypernatraemia	0.251	0.749	0.000
F05.9 Delirium, unspecified	0.233	0.767	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.230	0.770	0.000
I22 Subsequent myocardial infarction	0.224	0.776	0.000
I20.0 Unstable angina	0.222	0.778	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.222	0.778	0.000
E77 Disorders of glycoprotein metabolism	0.210	0.790	0.000
E76 Disorders of glycosaminoglycan metabolism	0.210	0.790	0.000
E72 Other disorders of amino-acid metabolism	0.210	0.790	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.210	0.790	0.000
E70 Disorders of aromatic amino-acid metabolism	0.210	0.790	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.210	0.790	0.000
E74 Other disorders of carbohydrate metabolism	0.209	0.791	0.000
E79 Disorders of purine and pyrimidine metabolism	0.199	0.800	0.000
E87.7 Fluid overload	0.199	0.801	0.000
Z95.1 Presence of aortocoronary bypass graft	0.196	0.804	0.000
E85 Amyloidosis	0.188	0.812	0.000
E84 Cystic fibrosis	0.187	0.813	0.000
E87.4 Mixed disorder of acid-base balance	0.187	0.813	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.186	0.814	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.182	0.818	0.000
E73 Lactose intolerance	0.177	0.823	0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.165	0.835	0.000
E87.6 Hypokalaemia	0.164	0.836	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.151	0.849	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.151	0.849	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.151	0.849	0.000
E70.3 Albinism	0.151	0.849	0.000
E70.2 Disorders of tyrosine metabolism	0.151	0.849	0.000
E70.1 Other hyperphenylalaninaemias	0.151	0.849	0.000
E70.0 Classical phenylketonuria	0.151	0.849	0.000
E71.3 Disorders of fatty-acid metabolism	0.151	0.849	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.151	0.849	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.151	0.849	0.000
E71.0 Maple-syrup-urine disease	0.151	0.849	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.151	0.849	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.151	0.849	0.000
E72.5 Disorders of glycine metabolism	0.151	0.849	0.000
E72.4 Disorders of ornithine metabolism	0.151	0.849	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.151	0.849	0.000
E72.2 Disorders of urea cycle metabolism	0.151	0.849	0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.151	0.849	0.000
E72.0 Disorders of amino-acid transport	0.151	0.849	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.151	0.849	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.151	0.849	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.151	0.849	0.000
E76.2 Other mucopolysaccharidoses	0.151	0.849	0.000
E76.1 Mucopolysaccharidosis, type II	0.151	0.849	0.000
E76.0 Mucopolysaccharidosis, type I	0.151	0.849	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.151	0.849	0.000
E77.8 Other disorders of glycoprotein metabolism	0.151	0.849	0.000
E77.1 Defects in glycoprotein degradation	0.151	0.849	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.151	0.849	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.150	0.850	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.150	0.850	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.150	0.850	0.000
E74.2 Disorders of galactose metabolism	0.150	0.850	0.000
E74.1 Disorders of fructose metabolism	0.150	0.850	0.000
E74.0 Glycogen storage disease	0.150	0.850	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.149	0.850	0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.143	0.857	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.143	0.857	0.000
E79.1 Lesch-Nyhan syndrome	0.143	0.857	0.000
E85.9 Amyloidosis, unspecified	0.142	0.858	0.000
E85.8 Other amyloidosis	0.135	0.865	0.000
E85.2 Heredofamilial amyloidosis, unspecified	0.135	0.865	0.000
E85.1 Neuropathic heredofamilial amyloidosis	0.135	0.865	0.000
E85.0 Nonneuropathic heredofamilial amyloidosis	0.135	0.865	0.000
E84.8 Cystic fibrosis with other manifestations	0.134	0.866	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.134	0.866	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.134	0.866	0.000
E75.6 Lipid storage disorder, unspecified	0.134	0.866	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.134	0.866	0.000
E75.3 Sphingolipidosis, unspecified	0.134	0.866	0.000
E75.1 Other gangliosidosis	0.134	0.866	0.000
E75.0 GM2 gangliosidosis	0.134	0.866	0.000
E75.2 Other sphingolipidosis	0.134	0.866	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.134	0.866	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.132	0.867	0.000
E73.8 Other lactose intolerance	0.127	0.873	0.000
E73.1 Secondary lactase deficiency	0.127	0.873	0.000
E73.0 Congenital lactase deficiency	0.127	0.873	0.000
E85.4 Organ-limited amyloidosis	0.125	0.875	0.000
E85.3 Secondary systemic amyloidosis	0.116	0.883	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.116	0.883	0.000
E80.1 Porphyria cutanea tarda	0.116	0.884	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.112	0.887	0.000
E84.9 Cystic fibrosis, unspecified	0.110	0.889	0.000
E75.5 Other lipid storage disorders	0.110	0.890	0.000
I22.8 Subsequent myocardial infarction of other sites	0.110	0.890	0.000
E88 Other metabolic disorders	0.110	0.890	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.110	0.890	0.000
E80.5 Crigler-Najjar syndrome	0.109	0.891	0.000
E80.3 Defects of catalase and peroxydase	0.109	0.891	0.000
E80.0 Hereditary erythropoietic porphyria	0.109	0.891	0.000
E87.3 Alkalosis	0.109	0.891	0.000
E80.6 Other disorders of bilirubin metabolism	0.098	0.902	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.097	0.903	0.000
E80.2 Other porphyria	0.095	0.904	0.000
E87.2 Acidosis	0.094	0.906	0.000
Y40 Systemic antibiotics	0.094	0.906	0.000
E73.9 Lactose intolerance, unspecified	0.093	0.907	0.000
Y40.8 Other systemic antibiotics	0.092	0.908	0.000
Y40.0 Penicillins	0.088	0.912	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.088	0.912	0.000
Y40.6 Rifamycins	0.080	0.920	0.000
Y40.7 Antifungal antibiotics, systemically used	0.076	0.923	0.000
E88.1 Lipodystrophy, not elsewhere classified	0.075	0.924	0.000
Y40.5 Aminoglycosides	0.075	0.925	0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.075	0.925	0.000
E88.8 Other specified metabolic disorders	0.073	0.927	0.000
E89.1 Postprocedural hypoinsulinaemia	0.073	0.927	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.072	0.928	0.000
E88.3 Tumour lysis syndrome	0.071	0.928	0.000
E88.9 Metabolic disorder, unspecified	0.071	0.929	0.000
E89.4 Postprocedural ovarian failure	0.070	0.930	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.070	0.930	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.070	0.930	0.000
E89.5 Postprocedural testicular hypofunction	0.070	0.930	0.000
Y40.2 Chloramphenicol group	0.067	0.932	0.000
Y40.4 Tetracyclines	0.066	0.934	0.000
I25.2 Old myocardial infarction	0.066	0.934	0.000
Chapter V Mental and behavioural disorders	0.066	0.934	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.065	0.935	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.065	0.935	0.000
E80.4 Gilbert's syndrome	0.062	0.938	0.000
Y54.8 Agents affecting uric acid metabolism	0.061	0.939	0.000
E89.3 Postprocedural hypopituitarism	0.060	0.939	0.000
E87.5 Hyperkalaemia	0.057	0.943	0.000
Y40.9 Systemic antibiotic, unspecified	0.055	0.945	0.000
E89.2 Postprocedural hypoparathyroidism	0.055	0.945	0.000
Y40.3 Macrolides	0.054	0.946	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.053	0.947	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.053	0.947	0.000
Y54.4 Loop [high-ceiling] diuretics	0.053	0.947	0.000
Y43.3 Other antineoplastic drugs	0.052	0.948	0.000
Y43 Primarily systemic agents	0.052	0.948	0.000
E88.2 Lipomatosis, not elsewhere classified	0.052	0.948	0.001
Y53 Agents primarily affecting the gastro-intestinal system	0.052	0.948	0.000
Y54.3 Benzothiadiazine derivatives	0.051	0.949	0.000
F60-F69 Disorders of adult personality and behaviour	0.051	0.949	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.051	0.949	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.051	0.949	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.050	0.949	0.000
Y54.0 Mineralocorticoids	0.050	0.950	0.000
Y54.7 Agents affecting calcification	0.050	0.950	0.000
Y54.5 Other diuretics	0.050	0.950	0.000
Y58 Bacterial vaccines	0.049	0.951	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.048	0.952	0.000
Y59 Other and unspecified vaccines and biological substances	0.047	0.952	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.047	0.952	0.000
Y54.9 Mineral salts, not elsewhere classified	0.047	0.953	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.047	0.953	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.047	0.953	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.047	0.953	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.047	0.953	0.000
F80-F89 Disorders of psychological development	0.047	0.953	0.000
F70-F79 Mental retardation	0.045	0.954	0.000
F30-F39 Mood [affective] disorders	0.045	0.955	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.045	0.955	0.000
Y47.1 Benzodiazepines	0.044	0.955	0.000
Y56.3 Emollients, demulcents and protectants	0.044	0.956	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.044	0.956	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.044	0.956	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.044	0.956	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.043	0.956	0.000
F55 Abuse of non-dependence-producing substances	0.043	0.957	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.042	0.958	0.000
F60 Specific personality disorders	0.042	0.958	0.000
Y53.4 Other laxatives	0.042	0.958	0.000
F60.3 Emotionally unstable personality disorder	0.041	0.959	0.000
F99-F99 Unspecified mental disorder	0.040	0.960	0.000
F98 Other behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.039	0.960	0.000
Y41.1 Antimycobacterial drugs	0.039	0.961	0.000
F84 Pervasive developmental disorders	0.039	0.961	0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.039	0.961	0.000
Y43.2 Antineoplastic natural products	0.039	0.961	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.039	0.961	0.000
F61 Mixed and other personality disorders	0.039	0.961	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.039	0.961	0.000
Y52 Agents primarily affecting the cardiovascular system	0.039	0.961	0.000
F39 Unspecified mood [affective] disorder	0.039	0.961	0.000
F62 Enduring personality changes, not attributable to brain damage and disease	0.038	0.962	0.000
Y56.9 Topical agent, unspecified	0.038	0.962	0.000
Y56.8 Other topical agents	0.038	0.962	0.000
Y56.7 Dental drugs, topically applied	0.038	0.962	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.038	0.962	0.000
Y56.5 Ophthalmological drugs and preparations	0.038	0.962	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.038	0.962	0.000
Y56.2 Local astringents and local detergents	0.038	0.962	0.000
Y56.1 Antipruritics	0.038	0.962	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.038	0.962	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.038	0.962	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.038	0.962	0.000
Y47.4 Bromine compounds	0.038	0.962	0.000
Y47.3 Paraldehyde	0.038	0.962	0.000
Y47.2 Chloral derivatives	0.038	0.962	0.000
Y47.0 Barbiturates, not elsewhere classified	0.038	0.962	0.000
Y58.0 BCG vaccine	0.038	0.962	0.000
Y43.9 Primarily systemic agent, unspecified	0.037	0.962	0.000
Y43.8 Other primarily systemic agents, not elsewhere classified	0.037	0.962	0.000
Y43.6 Enzymes, not elsewhere classified	0.037	0.962	0.000
Y43.5 Acidifying and alkalising agents	0.037	0.962	0.000
F31 Bipolar affective disorder	0.037	0.963	0.000
Y42.1 Thyroid hormones and substitutes	0.037	0.963	0.000
F50 Eating disorders	0.037	0.963	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.037	0.963	0.000
Y53.7 Emetics	0.037	0.963	0.000
Y53.6 Antidiarrhoeal drugs	0.037	0.963	0.000
Y53.5 Digestants	0.037	0.963	0.000
Y53.3 Saline and osmotic laxatives	0.037	0.963	0.000
Y53.0 Histamine H2-receptor antagonists	0.037	0.963	0.000
F69 Unspecified disorder of adult personality and behaviour	0.037	0.963	0.000
F30 Manic episode	0.037	0.963	0.000
Y53.2 Stimulant laxatives	0.037	0.963	0.000
F53 Mental and behavioural disorders associated with the puerperium, not elsewhere classified	0.037	0.963	0.000
F68 Other disorders of adult personality and behaviour	0.037	0.963	0.000
F66 Psychological and behavioural disorders associated with sexual development and orientation	0.037	0.963	0.000
F65 Disorders of sexual preference	0.037	0.963	0.000
F63 Habit and impulse disorders	0.037	0.963	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.037	0.963	0.000
Chapter XX External causes of morbidity and mortality	0.037	0.963	0.000
F59 Unspecified behavioural syndromes associated with physiological disturbances and physical factors	0.036	0.963	0.000
F54 Psychological and behavioural factors associated with disorders or diseases classified elsewhere	0.036	0.963	0.000
F95 Tic disorders	0.036	0.964	0.000
F94 Disorders of social functioning with onset specific to childhood and adolescence	0.036	0.964	0.000
F93 Emotional disorders with onset specific to childhood	0.036	0.964	0.000
F92 Mixed disorders of conduct and emotions	0.036	0.964	0.000
F91 Conduct disorders	0.036	0.964	0.000
F90 Hyperkinetic disorders	0.036	0.964	0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms	0.036	0.964	0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression	0.036	0.964	0.000
Y59.0 Viral vaccines	0.036	0.964	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.036	0.964	0.000
F22 Persistent delusional disorders	0.036	0.964	0.000
Y58.9 Other and unspecified bacterial vaccines	0.035	0.964	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.035	0.964	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.035	0.964	0.000
Y58.5 Diphtheria vaccine	0.035	0.964	0.000
Y58.4 Tetanus vaccine	0.035	0.964	0.000
Y58.3 Plague vaccine	0.035	0.964	0.000
Y58.2 Cholera vaccine	0.035	0.964	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.035	0.964	0.000
F51 Nonorganic sleep disorders	0.035	0.965	0.000
Y46.2 Hydantoin derivatives	0.035	0.965	0.000
Y41.5 Antiviral drugs	0.035	0.965	0.000
Y46.7 Anti-Parkinsonism drugs	0.035	0.965	0.000
Y42.4 Oral contraceptives	0.034	0.966	0.000
Y59.9 Vaccine or biological substance, unspecified	0.034	0.966	0.000
Y59.8 Other specified vaccines and biological substances	0.034	0.966	0.000
Y59.2 Protozoal vaccines	0.034	0.966	0.000
Y59.1 Rickettsial vaccines	0.034	0.966	0.000
Y49.9 Psychotropic drug, unspecified	0.034	0.966	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.034	0.966	0.000
Y49.7 Psychostimulants with abuse potential	0.034	0.966	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.034	0.966	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.034	0.966	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.034	0.966	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.034	0.966	0.000
Y44 Agents primarily affecting blood constituents	0.034	0.966	0.000
F84.5 Asperger's syndrome	0.034	0.966	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.034	0.966	0.000
Y41.4 Anthelminthics	0.034	0.966	0.000
Y41.3 Other antiprotozoal drugs	0.034	0.966	0.000
Y50.9 Central nervous system stimulant, unspecified	0.034	0.966	0.000
Y50.8 Other central nervous system stimulants	0.034	0.966	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.034	0.966	0.000
Y50.1 Opioid receptor antagonists	0.034	0.966	0.000
Y50.0 Analeptics	0.034	0.966	0.000
F89 Unspecified disorder of psychological development	0.034	0.966	0.000
F88 Other disorders of psychological development	0.034	0.966	0.000
F83 Mixed specific developmental disorders	0.034	0.966	0.000
F82 Specific developmental disorder of motor function	0.034	0.966	0.000
Y43.0 Antiallergic and antiemetic drugs	0.033	0.966	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.034	0.966	0.000
Y59.3 Immunoglobulin	0.033	0.967	0.000
F29 Unspecified nonorganic psychosis	0.033	0.967	0.000
Y49.5 Other antipsychotics and neuroleptics	0.033	0.967	0.000
F78 Other mental retardation	0.033	0.967	0.000
F73 Profound mental retardation	0.033	0.967	0.000
F72 Severe mental retardation	0.033	0.967	0.000
F71 Moderate mental retardation	0.033	0.967	0.000
F70 Mild mental retardation	0.033	0.967	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.033	0.967	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.033	0.967	0.000
F38 Other mood [affective] disorders	0.033	0.967	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.033	0.967	0.000
R46 Symptoms and signs involving appearance and behaviour	0.033	0.967	0.000
Y55.4 Expectorants	0.032	0.968	0.000
R40 Somnolence, stupor and coma	0.032	0.968	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.032	0.968	0.000
Y55.5 Anticommon cold drugs	0.032	0.968	0.000
Y55.3 Antitussives	0.032	0.968	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.032	0.968	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.032	0.968	0.000
Y55.0 Oxytocic drugs	0.032	0.968	0.000
F30.9 Manic episode, unspecified	0.032	0.968	0.000
Y46.8 Antispasticity drugs	0.032	0.968	0.000
Y46.3 Deoxybarbiturates	0.032	0.968	0.000
Y46.1 Oxazolidinediones	0.032	0.968	0.000
Y46.0 Succinimides	0.032	0.968	0.000
Y42.9 Other and unspecified hormone antagonists	0.032	0.968	0.000
Y42.7 Androgens and anabolic congeners	0.032	0.968	0.000
F28 Other nonorganic psychotic disorders	0.032	0.968	0.000
F24 Induced delusional disorder	0.032	0.968	0.000
F21 Schizotypal disorder	0.032	0.968	0.000
Y46.5 Valproic acid	0.031	0.968	0.000
F98.5 Stuttering [stammering]	0.031	0.968	0.000
F60.7 Dependent personality disorder	0.031	0.968	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.031	0.969	0.000
V10-V19 Pedal cyclist injured in transport accident	0.031	0.969	0.000
Y49.2 Other and unspecified antidepressants	0.031	0.969	0.000
Y41.0 Sulphonamides	0.031	0.969	0.000
Y42.2 Antithyroid drugs	0.031	0.969	0.000
Y48 Anaesthetics and therapeutic gases	0.031	0.969	0.000
F79 Unspecified mental retardation	0.031	0.969	0.000
V95-V97 Air and space transport accidents	0.031	0.969	0.000
F60.5 Anankastic personality disorder	0.031	0.969	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.031	0.969	0.000
R46.8 Other symptoms and signs involving appearance and behaviour	0.031	0.969	0.000
F60.4 Histrionic personality disorder	0.030	0.969	0.000
F60.2 Dissocial personality disorder	0.030	0.969	0.000
F60.1 Schizoid personality disorder	0.030	0.969	0.000
V01-V09 Pedestrian injured in transport accident	0.030	0.970	0.000
R40.2 Coma, unspecified	0.030	0.970	0.000
F52 Sexual dysfunction, not caused by organic disorder or disease	0.030	0.970	0.000
F31.7 Bipolar affective disorder, currently in remission	0.030	0.970	0.000
V17 Pedal cyclist injured in collision with fixed or stationary object	0.030	0.970	0.000
F23 Acute and transient psychotic disorders	0.030	0.970	0.000
X59 Exposure to unspecified factor	0.030	0.970	0.000
F25 Schizoaffective disorders	0.030	0.970	0.000
F30.2 Mania with psychotic symptoms	0.030	0.970	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.030	0.970	0.000
X00-X09 Exposure to smoke, fire and flames	0.029	0.970	0.000
F33 Recurrent depressive disorder	0.029	0.971	0.000
Y46.6 Other and unspecified antiepileptics	0.029	0.971	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.029	0.971	0.000
F62.9 Enduring personality change, unspecified	0.029	0.971	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.029	0.971	0.000
F80 Specific developmental disorders of speech and language	0.029	0.971	0.000
F64 Gender identity disorders	0.029	0.971	0.000
F50.9 Eating disorder, unspecified	0.029	0.971	0.000
F84.0 Childhood autism	0.029	0.971	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.029	0.971	0.000
V98-V99 Other and unspecified transport accidents	0.029	0.971	0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.029	0.971	0.000
F60.8 Other specific personality disorders	0.029	0.971	0.000
F98.9 Unspecified behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.028	0.971	0.000
F98.8 Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.028	0.971	0.000
F98.6 Cluttering	0.028	0.971	0.000
F98.4 Stereotyped movement disorders	0.028	0.971	0.000
F98.3 Pica of infancy and childhood	0.028	0.971	0.000
F98.2 Feeding disorder of infancy and childhood	0.028	0.971	0.000
F98.1 Nonorganic encopresis	0.028	0.971	0.000
F98.0 Nonorganic enuresis	0.028	0.971	0.000
F81 Specific developmental disorders of scholastic skills	0.029	0.971	0.000
X20-X29 Contact with venomous animals and plants	0.029	0.971	0.000
F84.9 Pervasive developmental disorder, unspecified	0.028	0.972	0.000
F84.8 Other pervasive developmental disorders	0.028	0.972	0.000
F84.4 Overactive disorder associated with mental retardation and stereotyped movements	0.028	0.972	0.000
F84.3 Other childhood disintegrative disorder	0.028	0.972	0.000
F84.2 Rett's syndrome	0.028	0.972	0.000
F84.1 Atypical autism	0.028	0.972	0.000
F34 Persistent mood [affective] disorders	0.028	0.972	0.000
W75-W84 Other accidental threats to breathing	0.028	0.972	0.000
F22.9 Persistent delusional disorder, unspecified	0.028	0.972	0.000
Y77 Ophthalmic devices associated with adverse incidents	0.028	0.972	0.000
Y45.1 Salicylates	0.028	0.972	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.028	0.972	0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.028	0.972	0.000
F22.0 Delusional disorder	0.028	0.972	0.000
F62.8 Other enduring personality changes	0.028	0.972	0.000
F62.1 Enduring personality change after psychiatric illness	0.028	0.972	0.000
F62.0 Enduring personality change after catastrophic experience	0.028	0.972	0.000
V40-V49 Car occupant injured in transport accident	0.028	0.972	0.000
F60.0 Paranoid personality disorder	0.028	0.972	0.000
Y72 Otorhinolaryngological devices associated with adverse incidents	0.028	0.972	0.000
X59.2 School, other institution and public administrative area	0.028	0.972	0.000
X10-X19 Contact with heat and hot substances	0.027	0.972	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.027	0.973	0.000
F30.1 Mania without psychotic symptoms	0.027	0.973	0.000
X30-X39 Exposure to forces of nature	0.027	0.973	0.000
F53.0 Mild mental and behavioural disorders associated with the puerperium, not elsewhere classified	0.027	0.973	0.000
F60.6 Anxious [avoidant] personality disorder	0.027	0.973	0.000
Y71 Cardiovascular devices associated with adverse incidents	0.027	0.973	0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.027	0.973	0.000
F50.8 Other eating disorders	0.027	0.973	0.000
F50.5 Vomiting associated with other psychological disturbances	0.027	0.973	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations