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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7297186
log Bayes Factor = 6.68652
Chromosome 12   position 111,778,178  (GRCh37) Explore rs7297186 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.008 0.992
E06 Thyroiditis
0.000 0.019 0.981
E07 Other disorders of thyroid
0.000 0.033 0.967
E07.9 Disorder of thyroid, unspecified
0.000 0.051 0.949
I10 Essential (primary) hypertension
0.000 0.055 0.945
E06.3 Autoimmune thyroiditis
0.000 0.058 0.942
E04 Other non-toxic goitre
0.000 0.085 0.915
E06.9 Thyroiditis, unspecified
0.000 0.116 0.884
E03.8 Other specified hypothyroidism
0.000 0.118 0.882
E04.1 Non-toxic single thyroid nodule
0.000 0.128 0.872
I10-I15 Hypertensive diseases
0.000 0.141 0.859
I12 Hypertensive renal disease
0.000 0.180 0.820
I12.9 Hypertensive renal disease without renal failure
0.000 0.205 0.795
E04.9 Non-toxic goitre, unspecified
0.000 0.235 0.765
I15 Secondary hypertension
0.000 0.258 0.742
E05.8 Other thyrotoxicosis
0.000 0.262 0.738
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.287 0.713
E05.4 Thyrotoxicosis factitia
0.000 0.287 0.713
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.287 0.713
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.287 0.713
E06.4 Drug-induced thyroiditis
0.000 0.297 0.703
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.297 0.703
E06.1 Subacute thyroiditis
0.000 0.297 0.703
E06.0 Acute thyroiditis
0.000 0.297 0.703
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.297 0.703
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.299 0.700
E06.5 Other chronic thyroiditis
0.000 0.302 0.698
E04.0 Non-toxic diffuse goitre
0.000 0.306 0.694
E07.1 Dyshormogenetic goitre
0.000 0.307 0.693
E07.0 Hypersecretion of calcitonin
0.000 0.307 0.693
I15.1 Hypertension secondary to other renal disorders
0.000 0.315 0.685
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.331 0.669
E04.8 Other specified non-toxic goitre
0.000 0.344 0.656
I11 Hypertensive heart disease
0.000 0.359 0.641
I13 Hypertensive heart and renal disease
0.000 0.384 0.616
E07.8 Other specified disorders of thyroid
0.000 0.389 0.611
I12.0 Hypertensive renal disease with renal failure
0.000 0.443 0.556
I15.8 Other secondary hypertension
0.000 0.468 0.532
I15.2 Hypertension secondary to endocrine disorders
0.000 0.468 0.532
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
I15.0 Renovascular hypertension
0.000 0.486 0.514
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.486 0.514
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.500 0.500
D86 Sarcoidosis
0.000 0.525 0.475
D86.0 Sarcoidosis of lung
0.000 0.527 0.473
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.528 0.472
D80-D89 Certain disorders involving the immune mechanism
0.000 0.528 0.472
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.529 0.471
I15.9 Seconday hypertension, unspecified
0.000 0.541 0.459
D86.9 Sarcoidosis, unspecified
0.000 0.546 0.454
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.558 0.442
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.558 0.442
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.558 0.442
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.558 0.442
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.560 0.440
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.630 0.370
D55-D59 Haemolytic anaemias
0.000 0.631 0.369
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.633 0.367
D59 Acquired haemolytic anaemia
0.000 0.637 0.363
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.642 0.357
D59.1 Other autoimmune haemolytic anaemias
0.000 0.645 0.355
D84 Other immunodeficiencies
0.000 0.653 0.347
D83 Common variable immunodeficiency
0.000 0.658 0.342
D82 Immunodeficiency associated with other major defects
0.000 0.661 0.339
D81 Combined immunodeficiencies
0.000 0.661 0.339
D89.3 Immune reconstitution syndrome
0.000 0.662 0.338
D86.1 Sarcoidosis of lymph nodes
0.000 0.671 0.329
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.676 0.324
D58 Other hereditary haemolytic anaemias
0.000 0.679 0.321
D89.1 Cryoglobulinaemia
0.000 0.690 0.310
D86.8 Sarcoidosis of other and combined sites
0.000 0.691 0.309
D86.3 Sarcoidosis of skin
0.000 0.698 0.302
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.699 0.300
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.700 0.300
D80 Immunodeficiency with predominantly antibody defects
0.000 0.706 0.294
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.710 0.290
D56 Thalassaemia
0.000 0.715 0.285
D84.9 Immunodeficiency, unspecified
0.000 0.729 0.271
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.730 0.270
D55 Anaemia due to enzyme disorders
0.000 0.736 0.264
D59.8 Other acquired haemolytic anaemias
0.000 0.740 0.260
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.740 0.260
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.740 0.260
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.740 0.260
D59.3 Haemolytic-uraemic syndrome
0.000 0.740 0.260
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.740 0.260
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.740 0.260
D57 Sickle-cell disorders
0.000 0.744 0.255
D72 Other disorders of white blood cells
0.000 0.746 0.254
D84.8 Other specified immunodeficiencies
0.000 0.751 0.249
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.751 0.249
D83.9 Common variable immunodeficiency, unspecified
0.000 0.752 0.248
D83.8 Other common variable immunodeficiencies
0.000 0.755 0.245
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.755 0.245
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.755 0.245
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.755 0.245
D81.9 Combined immunodeficiency, unspecified
0.000 0.757 0.243
D81.8 Other combined immunodeficiencies
0.000 0.757 0.243
D81.7 Major histocompatibility complex class II deficiency
0.000 0.757 0.243
D81.6 Major histocompatibility complex class I deficiency
0.000 0.757 0.243
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.757 0.243
D81.4 Nezelof's syndrome
0.000 0.757 0.243
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.757 0.243
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.757 0.243
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.757 0.243
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.757 0.243
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.757 0.243
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.757 0.243
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.757 0.243
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.757 0.243
D82.2 Immunodeficiency with short-limbed stature
0.000 0.757 0.243
D82.1 Di George's syndrome
0.000 0.757 0.243
D82.0 Wiskott-Aldrich syndrome
0.000 0.757 0.243
D72.8 Other specified disorders of white blood cells
0.000 0.757 0.243
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.763 0.237
D58.0 Hereditary spherocytosis
0.000 0.766 0.233
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.769 0.230
D58.1 Hereditary elliptocytosis
0.000 0.769 0.230
D84.1 Defects in the complement system
0.000 0.770 0.230
D56.3 Thalassaemia trait
0.000 0.774 0.226
D75 Other diseases of blood and blood-forming organs
0.000 0.777 0.223
D58.2 Other haemoglobinopathies
0.000 0.781 0.219
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.784 0.216
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.789 0.211
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.789 0.211
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.789 0.211
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.789 0.211
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.789 0.211
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.789 0.211
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.789 0.211
D75.2 Essential thrombocytosis
0.000 0.792 0.208
D60-D64 Aplastic and other anaemias
0.000 0.793 0.207
D56.9 Thalassaemia, unspecified
0.000 0.795 0.205
D56.8 Other thalassaemias
0.000 0.795 0.205
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.795 0.205
D56.2 Delta-beta thalassaemia
0.000 0.795 0.205
D56.1 Beta thalassaemia
0.000 0.795 0.205
D56.0 Alpha thalassaemia
0.000 0.795 0.205
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.802 0.198
D74 Methaemoglobinaemia
0.000 0.806 0.194
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.806 0.194
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.806 0.194
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.810 0.190
D55.8 Other anaemias due to enzyme disorders
0.000 0.810 0.190
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.810 0.190
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.810 0.190
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.810 0.190
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.810 0.190
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.815 0.184
D72.1 Eosinophilia
0.000 0.816 0.184
D57.8 Other sickle-cell disorders
0.000 0.816 0.183
D57.3 Sickle-cell trait
0.000 0.816 0.183
D57.2 Double heterozygous sickling disorders
0.000 0.816 0.183
D57.0 Sickle-cell anaemia with crisis
0.000 0.816 0.183
D72.9 Disorder of white blood cells, unspecified
0.000 0.818 0.182
D72.0 Genetic anomalies of leukocytes
0.000 0.818 0.182
E04.2 Non-toxic multinodular goitre
0.000 0.818 0.182
D57.1 Sickle-cell anaemia without crisis
0.000 0.825 0.174
D62 Acute posthaemorrhagic anaemia
0.000 0.825 0.174
D69 Purpura and other haemorrhagic conditions
0.000 0.826 0.174
D75.0 Familial erythrocytosis
0.000 0.827 0.173
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.834 0.166
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.835 0.165
E50-E64 Other nutritional deficiencies
0.000 0.842 0.158
D67 Hereditary factor IX deficiency
0.000 0.845 0.155
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.846 0.154
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.849 0.150
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.852 0.148
E53 Deficiency of other B group vitamins
0.000 0.852 0.148
D76.3 Other histiocytosis syndromes
0.000 0.853 0.147
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.854 0.146
E53.8 Deficiency of other specified B group vitamins
0.000 0.857 0.143
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.858 0.142
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.858 0.142
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.858 0.142
D75.1 Secondary polycythaemia
0.000 0.861 0.139
D74.9 Methaemoglobinaemia, unspecified
0.000 0.861 0.139
D74.8 Other methaemoglobinaemias
0.000 0.861 0.139
D74.0 Congenital methaemoglobinaemia
0.000 0.861 0.139
E61 Deficiency of other nutrient elements
0.000 0.861 0.139
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.864 0.136
D66 Hereditary factor VIII deficiency
0.000 0.866 0.133
D69.4 Other primary thrombocytopenia
0.000 0.867 0.133
D50-D53 Nutritional anaemias
0.000 0.874 0.126
D69.8 Other specified haemorrhagic conditions
0.000 0.875 0.125
D69.1 Qualitative platelet defects
0.000 0.875 0.125
D69.2 Other nonthrombocytopenic purpura
0.000 0.876 0.124
D69.9 Haemorrhagic condition, unspecified
0.000 0.877 0.123
E61.1 Iron deficiency
0.000 0.878 0.122
D64 Other anaemias
0.000 0.879 0.120
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.880 0.120
D61 Other aplastic anaemias
0.000 0.882 0.118
D69.5 Secondary thrombocytopenia
0.000 0.883 0.117
E16 Other disorders of pancreatic internal secretion
0.000 0.885 0.115
E55 Vitamin D deficiency
0.000 0.886 0.114
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.887 0.113
E63 Other nutritional deficiencies
0.000 0.887 0.113
E51 Thiamine deficiency
0.000 0.887 0.113
E50 Vitamin A deficiency
0.000 0.887 0.113
E60 Dietary zinc deficiency
0.000 0.887 0.113
E59 Dietary selenium deficiency
0.000 0.887 0.113
E58 Dietary calcium deficiency
0.000 0.887 0.113
E54 Ascorbic acid deficiency
0.000 0.887 0.113
E52 Niacin deficiency [pellagra]
0.000 0.887 0.113
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.888 0.112
D68 Other coagulation defects
0.000 0.891 0.108
D60.9 Acquired pure red cell aplasia, unspecified
0.000 0.893 0.106
D60.8 Other acquired pure red cell aplasias
0.000 0.893 0.106
D60.1 Transient acquired pure red cell aplasia
0.000 0.893 0.106
D60.0 Chronic acquired pure red cell aplasia
0.000 0.893 0.106
E53.1 Pyridoxine deficiency
0.000 0.894 0.106
E53.0 Riboflavin deficiency
0.000 0.894 0.106
E61.2 Magnesium deficiency
0.000 0.894 0.106
E16.2 Hypoglycaemia, unspecified
0.000 0.895 0.105
E56 Other vitamin deficiencies
0.000 0.897 0.103
D69.0 Allergic purpura
0.000 0.897 0.102
D73 Diseases of spleen
0.000 0.899 0.101
E61.9 Deficiency of nutrient element, unspecified
0.000 0.900 0.100
E61.8 Deficiency of other specified nutrient elements
0.000 0.900 0.100
E61.7 Deficiency of multiple nutrient elements
0.000 0.900 0.100
E61.6 Vanadium deficiency
0.000 0.900 0.100
E61.5 Molybdenum deficiency
0.000 0.900 0.100
E61.4 Chromium deficiency
0.000 0.900 0.100
E61.3 Manganese deficiency
0.000 0.900 0.100
E61.0 Copper deficiency
0.000 0.900 0.100
E15 Nondiabetic hypoglycaemic coma
0.000 0.902 0.097
D53 Other nutritional anaemias
0.000 0.904 0.096
D68.5 Primary Thrombophilia
0.000 0.905 0.095
E53.9 Vitamin B deficiency, unspecified
0.000 0.905 0.095
D61.1 Drug-induced aplastic anaemia
0.000 0.906 0.094
D64.8 Other specified anaemias
0.000 0.909 0.091
E40-E46 Malnutrition
0.000 0.910 0.090
D52 Folate deficiency anaemia
0.000 0.912 0.088
D64.4 Congenital dyserythropoietic anaemia
0.000 0.913 0.086
D64.3 Other sideroblastic anaemias
0.000 0.913 0.086
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.913 0.086
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.913 0.086
D64.0 Hereditary sideroblastic anaemia
0.000 0.913 0.086
E16.1 Other hypoglycaemia
0.000 0.914 0.086
E10-E14 Diabetes mellitus
0.000 0.914 0.086
D61.8 Other specified aplastic anaemias
0.000 0.915 0.085
D61.3 Idiopathic aplastic anaemia
0.000 0.915 0.085
D61.2 Aplastic anaemia due to other external agents
0.000 0.915 0.085
D68.6 Other Thrombophilia
0.000 0.915 0.085
E10 Insulin-dependent diabetes mellitus
0.000 0.917 0.083
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.917 0.083
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.917 0.083
E16.4 Abnormal secretion of gastrin
0.000 0.917 0.083
E16.3 Increased secretion of glucagon
0.000 0.917 0.083
E10.3 With ophthalmic complications
0.000 0.917 0.082
D68.1 Hereditary factor XI deficiency
0.000 0.918 0.082
E55.9 Vitamin D deficiency, unspecified
0.000 0.918 0.082
E55.0 Rickets, active
0.000 0.918 0.082
E50.9 Vitamin A deficiency, unspecified
0.000 0.918 0.081
E50.8 Other manifestations of vitamin A deficiency
0.000 0.918 0.081
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.918 0.081
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.918 0.081
E50.5 Vitamin A deficiency with night blindness
0.000 0.918 0.081
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.918 0.081
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.918 0.081
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.918 0.081
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.918 0.081
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.918 0.081
E51.9 Thiamine deficiency, unspecified
0.000 0.918 0.081
E51.8 Other manifestations of thiamine deficiency
0.000 0.918 0.081
E51.2 Wernicke's encephalopathy
0.000 0.918 0.081
E51.1 Beriberi
0.000 0.918 0.081
E63.9 Nutritional deficiency, unspecified
0.000 0.918 0.081
E63.8 Other specified nutritional deficiencies
0.000 0.918 0.081
E63.1 Imbalance of constituents of food intake
0.000 0.918 0.081
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.918 0.081
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.918 0.081
E64.8 Sequelae of other nutritional deficiencies
0.000 0.918 0.081
E64.3 Sequelae of rickets
0.000 0.918 0.081
E64.2 Sequelae of vitamin C deficiency
0.000 0.918 0.081
E64.1 Sequelae of vitamin A deficiency
0.000 0.918 0.081
E64.0 Sequelae of protein-energy malnutrition
0.000 0.918 0.081
D68.8 Other specified coagulation defects
0.000 0.919 0.081
D63.1 Anaemia in other chronic diseases classified elsewhere
0.000 0.919 0.081
E70-E90 Metabolic disorders
0.000 0.922 0.078
D61.0 Constitutional aplastic anaemia
0.000 0.922 0.078
D63.8 Anaemia in other chronic diseases classified elsewhere
0.000 0.925 0.075
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.925 0.075
D53.9 Nutritional anaemia, unspecified
0.000 0.925 0.075
D73.0 Hyposplenism
0.000 0.925 0.074
E56.9 Vitamin deficiency, unspecified
0.000 0.926 0.074
E56.8 Deficiency of other vitamins
0.000 0.926 0.074
E56.0 Deficiency of vitamin E
0.000 0.926 0.074
D68.4 Acquired coagulation factor deficiency
0.000 0.926 0.074
D68.0 Von Willebrand's disease
0.000 0.927 0.073
Z95.1 Presence of aortocoronary bypass graft
0.000 0.927 0.073
E80.4 Gilbert's syndrome
0.000 0.927 0.073
D73.9 Disease of spleen, unspecified
0.000 0.927 0.072
D73.3 Abscess of spleen
0.000 0.927 0.072
D73.2 Chronic congestive splenomegaly
0.000 0.927 0.072
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.927 0.073
E10.0 With coma
0.000 0.927 0.073
E85 Amyloidosis
0.000 0.928 0.072
Z95.4 Presence of other heart-valve replacement
0.000 0.930 0.070
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.930 0.070
D53.8 Other specified nutritional anaemias
0.000 0.931 0.069
D53.2 Scorbutic anaemia
0.000 0.931 0.069
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.931 0.069
D53.0 Protein deficiency anaemia
0.000 0.931 0.069
D73.1 Hypersplenism
0.000 0.932 0.068
D51 Vitamin B12 deficiency anaemia
0.000 0.932 0.067
D73.4 Cyst of spleen
0.000 0.933 0.067
E10.4 With neurological complications
0.000 0.935 0.065
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.935 0.065
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.935 0.064
E45 Retarded development following protein-energy malnutrition
0.000 0.935 0.064
E43 Unspecified severe protein-energy malnutrition
0.000 0.935 0.064
E42 Marasmic kwashiorkor
0.000 0.935 0.064
E41 Nutritional marasmus
0.000 0.935 0.064
E40 Kwashiorkor
0.000 0.935 0.064
Z95.2 Presence of prosthetic heart valve
0.000 0.935 0.065
E56.1 Deficiency of vitamin K
0.000 0.936 0.064
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.936 0.064
E10.8 With unspecified complications
0.000 0.936 0.064
D52.8 Other folate deficiency anaemias
0.000 0.937 0.063
D52.1 Drug-induced folate deficiency anaemia
0.000 0.937 0.063
D52.0 Dietary folate deficiency anaemia
0.000 0.937 0.063
E10.9 Without complications
0.000 0.937 0.063
E12 Malnutrition-related diabetes mellitus
0.000 0.938 0.062
E10.5 With peripheral circulatory complications
0.000 0.939 0.060
D52.9 Folate deficiency anaemia, unspecified
0.000 0.940 0.060
E85.9 Amyloidosis, unspecified
0.000 0.940 0.060
E85.3 Secondary systemic amyloidosis
0.000 0.941 0.059
D69.6 Thrombocytopenia, unspecified
0.000 0.942 0.058
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.942 0.058
E80.6 Other disorders of bilirubin metabolism
0.000 0.943 0.057
E85.4 Organ-limited amyloidosis
0.000 0.943 0.057
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.943 0.057
E84 Cystic fibrosis
0.000 0.943 0.057
E79 Disorders of purine and pyrimidine metabolism
0.000 0.943 0.056
E77 Disorders of glycoprotein metabolism
0.000 0.943 0.056
E76 Disorders of glycosaminoglycan metabolism
0.000 0.943 0.056
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.943 0.056
E72 Other disorders of amino-acid metabolism
0.000 0.943 0.056
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.943 0.056
E70 Disorders of aromatic amino-acid metabolism
0.000 0.943 0.056
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.943 0.056
E10.6 With other specified complications
0.000 0.945 0.055
D63.0 Anaemia in neoplastic disease
0.000 0.945 0.055
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.946 0.054
E80.5 Crigler-Najjar syndrome
0.000 0.946 0.054
E80.3 Defects of catalase and peroxydase
0.000 0.946 0.054
E80.1 Porphyria cutanea tarda
0.000 0.946 0.054
E80.0 Hereditary erythropoietic porphyria
0.000 0.946 0.054
E86 Volume depletion
0.000 0.946 0.054
J34.2 Deviated nasal septum
0.053 0.947 0.000
Z95.3 Presence of xenogenic heart valve
0.000 0.948 0.052
E10.2 With renal complications
0.000 0.948 0.052
E85.8 Other amyloidosis
0.000 0.948 0.051
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.948 0.051
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.948 0.051
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.948 0.051
D73.8 Other diseases of spleen
0.001 0.949 0.050
E73 Lactose intolerance
0.000 0.950 0.050
D73.5 Infarction of spleen
0.000 0.951 0.049
D51.2 Transcobalamin II deficiency
0.000 0.951 0.048
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.951 0.048
D64.9 Anaemia, unspecified
0.000 0.952 0.048
E74 Other disorders of carbohydrate metabolism
0.000 0.952 0.047
E65-E68 Obesity and other hyperalimentation
0.000 0.953 0.047
E80.2 Other porphyria
0.000 0.953 0.047
E10.7 With multiple complications
0.000 0.953 0.047
E13 Other specified diabetes mellitus
0.000 0.953 0.047
E44.1 Mild protein-energy malnutrition
0.000 0.953 0.046
E44.0 Moderate protein-energy malnutrition
0.000 0.953 0.046
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.955 0.045
D61.9 Aplastic anaemia, unspecified
0.000 0.955 0.045
E88 Other metabolic disorders
0.000 0.955 0.045
E12.9 Without complications
0.000 0.956 0.044
E12.8 With unspecified complications
0.000 0.956 0.044
E12.7 With multiple complications
0.000 0.956 0.044
E12.6 With other specified complications
0.000 0.956 0.044
E12.5 With peripheral circulatory complications
0.000 0.956 0.044
E12.4 With neurological complications
0.000 0.956 0.044
E12.3 With ophthalmic complications
0.000 0.956 0.044
E12.2 With renal complications
0.000 0.956 0.044
E12.1 With ketoacidosis
0.000 0.956 0.044
E12.0 With coma
0.000 0.956 0.044
D68.2 Hereditary deficiency of other clotting factors
0.000 0.956 0.044
E10.1 With ketoacidosis
0.000 0.956 0.044
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.957 0.042
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.958 0.042
E84.9 Cystic fibrosis, unspecified
0.000 0.959 0.041
E84.8 Cystic fibrosis with other manifestations
0.000 0.959 0.041
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.959 0.041
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.959 0.041
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.959 0.041
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.959 0.041
E70.3 Albinism
0.000 0.959 0.041
E70.2 Disorders of tyrosine metabolism
0.000 0.959 0.041
E70.1 Other hyperphenylalaninaemias
0.000 0.959 0.041
E70.0 Classical phenylketonuria
0.000 0.959 0.041
E71.3 Disorders of fatty-acid metabolism
0.000 0.959 0.041
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.959 0.041
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.959 0.041
E71.0 Maple-syrup-urine disease
0.000 0.959 0.041
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.959 0.041
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.959 0.041
E72.5 Disorders of glycine metabolism
0.000 0.959 0.041
E72.4 Disorders of ornithine metabolism
0.000 0.959 0.041
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.959 0.041
E72.2 Disorders of urea cycle metabolism
0.000 0.959 0.041
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.959 0.041
E72.0 Disorders of amino-acid transport
0.000 0.959 0.041
E75.6 Lipid storage disorder, unspecified
0.000 0.959 0.041
E75.5 Other lipid storage disorders
0.000 0.959 0.041
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.959 0.041
E75.3 Sphingolipidosis, unspecified
0.000 0.959 0.041
E75.2 Other sphingolipidosis
0.000 0.959 0.041
E75.1 Other gangliosidosis
0.000 0.959 0.041
E75.0 GM2 gangliosidosis
0.000 0.959 0.041
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.959 0.041
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.959 0.041
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.959 0.041
E76.2 Other mucopolysaccharidoses
0.000 0.959 0.041
E76.1 Mucopolysaccharidosis, type II
0.000 0.959 0.041
E76.0 Mucopolysaccharidosis, type I
0.000 0.959 0.041
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.959 0.041
E77.8 Other disorders of glycoprotein metabolism
0.000 0.959 0.041
E77.1 Defects in glycoprotein degradation
0.000 0.959 0.041
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.959 0.041
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.959 0.041
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.959 0.041
E79.1 Lesch-Nyhan syndrome
0.000 0.959 0.041
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.959 0.041
E83 Disorders of mineral metabolism
0.000 0.959 0.041
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.959 0.041
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.961 0.039
E20-E35 Disorders of other endocrine glands
0.000 0.963 0.037
E88.2 Lipomatosis, not elsewhere classified
0.000 0.963 0.036
E83.4 Disorders of magnesium metabolism
0.000 0.964 0.036
E73.8 Other lactose intolerance
0.000 0.964 0.036
E73.1 Secondary lactase deficiency
0.000 0.964 0.036
E73.0 Congenital lactase deficiency
0.000 0.964 0.036
E46 Unspecified protein-energy malnutrition
0.000 0.964 0.036
E89.0 Postprocedural hypothyroidism
0.000 0.965 0.035
E87.3 Alkalosis
0.000 0.965 0.035
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.965 0.035
E22 Hyperfunction of pituitary gland
0.000 0.965 0.035
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.966 0.034
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.966 0.034
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.966 0.034
E74.2 Disorders of galactose metabolism
0.000 0.966 0.034
E74.1 Disorders of fructose metabolism
0.000 0.966 0.034
E74.0 Glycogen storage disease
0.000 0.966 0.034
E67 Other hyperalimentation
0.000 0.966 0.034
E68 Sequelae of hyperalimentation
0.000 0.966 0.034
E89.4 Postprocedural ovarian failure
0.000 0.966 0.034
E13.8 With unspecified complications
0.000 0.966 0.034
E13.7 With multiple complications
0.000 0.966 0.034
E13.6 With other specified complications
0.000 0.966 0.034
E13.5 With peripheral circulatory complications
0.000 0.966 0.034
E13.4 With neurological complications
0.000 0.966 0.034
E13.3 With ophthalmic complications
0.000 0.966 0.034
E13.2 With renal complications
0.000 0.966 0.034
E13.1 With ketoacidosis
0.000 0.966 0.034
E13.0 With coma
0.000 0.966 0.034
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.967 0.033
E88.8 Other specified metabolic disorders
0.000 0.967 0.033
E89.2 Postprocedural hypoparathyroidism
0.000 0.967 0.033
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.967 0.033
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.967 0.033
E89.5 Postprocedural testicular hypofunction
0.000 0.967 0.033
E89.1 Postprocedural hypoinsulinaemia
0.000 0.967 0.033
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.968 0.032
K61.0 Anal abscess
0.000 0.968 0.032
E28 Ovarian dysfunction
0.000 0.968 0.032
E87.7 Fluid overload
0.000 0.969 0.031
E88.9 Metabolic disorder, unspecified
0.000 0.970 0.030
E73.9 Lactose intolerance, unspecified
0.000 0.970 0.030
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.971 0.029
E83.8 Other disorders of mineral metabolism
0.000 0.971 0.029
E83.2 Disorders of zinc metabolism
0.000 0.971 0.029
E83.0 Disorders of copper metabolism
0.000 0.971 0.029
E87.4 Mixed disorder of acid-base balance
0.000 0.971 0.029
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.971 0.029
E28.2 Polycystic ovarian syndrome
0.000 0.972 0.028

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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