TreeWAS – Variant ID: rs73013159

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I25 Chronic ischaemic heart disease	0.000	0.000	1.000
I20-I25 Ischaemic heart diseases	0.000	0.000	1.000
I25.1 Atherosclerotic heart disease	0.000	0.000	1.000
I21 Acute myocardial infarction	0.000	0.005	0.995
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.987	0.013	0.000
M05-M14 Inflammatory polyarthropathies	0.986	0.014	0.000
M45-M49 Spondylopathies	0.983	0.017	0.000
I25.2 Old myocardial infarction	0.000	0.018	0.982
I20 Angina pectoris	0.000	0.018	0.982
I20.9 Angina pectoris, unspecified	0.000	0.025	0.975
M06 Other rheumatoid arthritis	0.973	0.027	0.000
M20-M25 Other joint disorders	0.969	0.031	0.000
M24 Other specific joint derangements	0.965	0.035	0.000
M24.1 Other articular cartilage disorders	0.963	0.037	0.000
M46 Other inflammatory spondylopathies	0.958	0.042	0.000
M24.16 Other articular cartilage disorders (Lower leg)	0.955	0.045	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.049	0.951
M06.9 Rheumatoid arthritis, unspecified	0.948	0.052	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.940	0.060	0.000
M48 Other spondylopathies	0.937	0.063	0.000
I21.4 Acute subendocardial myocardial infarction	0.000	0.079	0.921
I25.9 Chronic ischaemic heart disease, unspecified	0.000	0.081	0.919
M50-M54 Other dorsopathies	0.915	0.085	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.000	0.105	0.895
M13 Other arthritis	0.892	0.108	0.000
I49 Other cardiac arrhythmias	0.000	0.119	0.881
I24 Other acute ischaemic heart diseases	0.000	0.120	0.880
M06.4 Inflammatory polyarthropathy	0.876	0.124	0.000
E78.0 Pure hypercholesterolaemia	0.000	0.127	0.873
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.872	0.128	0.000
M21 Other acquired deformities of limbs	0.872	0.128	0.000
I30-I52 Other forms of heart disease	0.000	0.130	0.870
M54 Dorsalgia	0.867	0.133	0.000
M22 Disorders of patella	0.866	0.134	0.000
Chapter IX Diseases of the circulatory system	0.000	0.134	0.866
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)	0.863	0.137	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.859	0.141	0.000
I21.9 Acute myocardial infarction, unspecified	0.000	0.142	0.858
I49.8 Other specified cardiac arrhythmias	0.000	0.147	0.853
I49.0 Ventricular fibrillation and flutter	0.000	0.150	0.850
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.849	0.151	0.000
M48.0 Spinal stenosis	0.848	0.152	0.000
I38 Endocarditis, valve unspecified	0.000	0.153	0.847
M60-M63 Disorders of muscles	0.842	0.158	0.000
M48.5 Collapsed vertebra, not elsewhere classified	0.840	0.160	0.000
M47 Spondylosis	0.838	0.162	0.000
I49.9 Cardiac arrhythmia, unspecified	0.000	0.170	0.830
M05 Seropositive rheumatoid arthritis	0.829	0.171	0.000
I20.8 Other forms of angina pectoris	0.000	0.174	0.826
M65-M68 Disorders of synovium and tendon	0.826	0.174	0.000
I22 Subsequent myocardial infarction	0.000	0.175	0.825
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.823	0.177	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.000	0.183	0.817
M54.2 Cervicalgia	0.813	0.187	0.000
M11 Other crystal arthropathies	0.803	0.197	0.000
M48.07 Spinal stenosis (Lumbosacral region)	0.801	0.199	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.000	0.204	0.796
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.793	0.207	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.000	0.210	0.790
M22.4 Chondromalacia patellae	0.788	0.212	0.000
M10 Gout	0.786	0.214	0.000
M50 Cervical disk disorders	0.786	0.214	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.785	0.215	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.785	0.215	0.000
M47.8 Other spondylosis	0.782	0.218	0.000
M21.1 Varus deformity, not elsewhere classified	0.781	0.219	0.000
M13.9 Arthritis, unspecified	0.777	0.223	0.000
I26 Pulmonary embolism	0.000	0.231	0.769
M48.02 Spinal stenosis (Cervical region)	0.766	0.234	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.765	0.235	0.000
M40-M43 Deforming dorsopathies	0.765	0.235	0.000
M54.9 Dorsalgia, unspecified	0.760	0.240	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.759	0.241	0.000
M54.22 Cervicalgia (Cervical region)	0.758	0.242	0.000
M13.8 Other specified arthritis	0.757	0.243	0.000
I46 Cardiac arrest	0.000	0.245	0.755
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.000	0.250	0.750
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.750	0.250	0.000
M65 Synovitis and tenosynovitis	0.749	0.250	0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.749	0.251	0.000
M24.17 Other articular cartilage disorders (Ankle and foot)	0.749	0.251	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.747	0.252	0.000
M91-M94 Chondropathies	0.746	0.253	0.000
I49.5 Sick sinus syndrome	0.000	0.255	0.745
M24.2 Disorder of ligament	0.741	0.259	0.000
M49 Spondylopathies in diseases classified elsewhere	0.739	0.261	0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)	0.736	0.264	0.000
I25.3 Aneurysm of heart	0.000	0.269	0.731
I49.1 Atrial premature depolarisation	0.000	0.272	0.728
M21.2 Flexion deformity	0.726	0.273	0.000
I51 Complications and ill-defined descriptions of heart disease	0.000	0.277	0.723
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.721	0.279	0.000
M53 Other dorsopathies, not elsewhere classified	0.720	0.280	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.720	0.280	0.000
M50.1 Cervical disk disorder with radiculopathy	0.720	0.280	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.720	0.280	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.717	0.283	0.000
I25.6 Silent myocardial ischaemia	0.000	0.283	0.717
I23 Certain current complications following acute myocardial infarction	0.000	0.283	0.717
M86-M90 Other osteopathies	0.716	0.284	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.000	0.287	0.713
I21.3 Acute transmural myocardial infarction of unspecified site	0.000	0.287	0.713
I46.0 Cardiac arrest with successful resuscitation	0.000	0.287	0.712
M12 Other specific arthropathies	0.707	0.293	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.707	0.293	0.000
M08 Juvenile arthritis	0.707	0.293	0.000
M30 Polyarteritis nodosa and related conditions	0.706	0.294	0.000
M21.3 Wrist or foot drop (acquired)	0.706	0.294	0.000
M62 Other disorders of muscle	0.705	0.295	0.000
M07 Psoriatic and enteropathic arthropathies	0.704	0.296	0.000
M06.3 Rheumatoid nodule	0.704	0.296	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.703	0.297	0.000
M54.99 Dorsalgia, unspecified (Site unspecified)	0.702	0.298	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.000	0.299	0.701
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)	0.700	0.300	0.000
M06.8 Other specified rheumatoid arthritis	0.697	0.302	0.000
M06.2 Rheumatoid bursitis	0.697	0.302	0.000
M06.1 Adult-onset Still's disease	0.697	0.302	0.000
M13.97 Arthritis, unspecified (Ankle and foot)	0.697	0.303	0.000
M54.1 Radiculopathy	0.696	0.304	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.695	0.305	0.000
M33 Dermatopolymyositis	0.695	0.305	0.000
M32 Systemic lupus erythematosus	0.695	0.305	0.000
M24.9 Joint derangement, unspecified	0.692	0.308	0.000
M24.7 Protrusio acetabuli	0.692	0.308	0.000
M24.6 Ankylosis of joint	0.692	0.308	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.692	0.308	0.000
M24.19 Other articular cartilage disorders (Site unspecified)	0.690	0.309	0.000
M24.18 Other articular cartilage disorders (Other)	0.690	0.309	0.000
M24.14 Other articular cartilage disorders (Hand)	0.690	0.309	0.000
M24.12 Other articular cartilage disorders (Upper arm)	0.690	0.309	0.000
M24.10 Other articular cartilage disorders (Multiple sites)	0.690	0.309	0.000
M47.82 Other spondylosis (Cervical region)	0.690	0.310	0.000
M47.80 Other spondylosis (Multiple sites in spine)	0.688	0.312	0.000
M46.8 Other specified inflammatory spondylopathies	0.687	0.313	0.000
M46.5 Other infective spondylopathies	0.687	0.313	0.000
M46.4 Discitis, unspecified	0.687	0.313	0.000
M46.3 Infection of intervertebral disk (pyogenic)	0.687	0.313	0.000
M46.2 Osteomyelitis of vertebra	0.687	0.313	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.687	0.313	0.000
M46.0 Spinal enthesopathy	0.687	0.313	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.684	0.316	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.680	0.320	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.680	0.320	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.680	0.320	0.000
M22.8 Other disorders of patella	0.679	0.321	0.000
I25.5 Ischaemic cardiomyopathy	0.000	0.322	0.678
M14 Arthropathies in other diseases classified elsewhere	0.677	0.323	0.000
M06.0 Seronegative rheumatoid arthritis	0.675	0.325	0.000
I31 Other diseases of pericardium	0.000	0.325	0.675
M54.5 Low back pain	0.674	0.326	0.000
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.674	0.326	0.000
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)	0.674	0.326	0.000
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)	0.674	0.326	0.000
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)	0.674	0.326	0.000
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)	0.674	0.326	0.000
M48.9 Spondylopathy, unspecified	0.672	0.328	0.000
M48.8 Other specified spondylopathies	0.672	0.328	0.000
M48.4 Fatigue fracture of vertebra	0.672	0.328	0.000
M48.3 Traumatic spondylopathy	0.672	0.328	0.000
M48.2 Kissing spine	0.672	0.328	0.000
M48.1 Ankylosing hyperostosis [Forestier]	0.672	0.328	0.000
M11.2 Other chondrocalcinosis	0.672	0.328	0.000
M24.13 Other articular cartilage disorders (Forearm)	0.670	0.329	0.000
M00-M03 Infectious arthropathies	0.670	0.330	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.000	0.336	0.664
M60 Myositis	0.661	0.339	0.000
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.657	0.342	0.000
M54.4 Lumbago with sciatica	0.653	0.347	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.000	0.349	0.651
M13.94 Arthritis, unspecified (Hand)	0.651	0.349	0.000
M54.29 Cervicalgia-Site unspe	0.649	0.351	0.000
M21.4 Flat foot [pes planus] (acquired)	0.648	0.352	0.000
I51.8 Other ill-defined heart diseases	0.000	0.353	0.647
I22.8 Subsequent myocardial infarction of other sites	0.000	0.353	0.647
M47.88 Other spondylosis (Sacral and sacrococcygeal region)	0.646	0.354	0.000
I49.4 Other and unspecified premature depolarisation	0.000	0.355	0.645
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.644	0.356	0.000
M13.1 Monoarthritis, not elsewhere classified	0.640	0.360	0.000
M89 Other disorders of bone	0.636	0.364	0.000
M24.5 Contracture of joint	0.634	0.366	0.000
M34 Systemic sclerosis	0.632	0.368	0.000
I49.2 Junctional premature depolarisation	0.000	0.368	0.632
M47.1 Other spondylosis with myelopathy	0.631	0.369	0.000
I24.1 Dressler's syndrome	0.000	0.369	0.631
I05-I09 Chronic rheumatic heart diseases	0.000	0.370	0.630
M24.4 Recurrent dislocation and subluxation of joint	0.629	0.370	0.000
M48.00 Spinal stenosis (Multiple sites in spine)	0.629	0.371	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.628	0.372	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.628	0.372	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.628	0.372	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.628	0.372	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.628	0.372	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.628	0.372	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.628	0.372	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.628	0.372	0.000
M24.21 Disorder of ligament (Shoulder region)	0.628	0.372	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.373	0.627
M21.9 Acquired deformity of limb, unspecified	0.625	0.375	0.000
M21.8 Other specified acquired deformities of limbs	0.625	0.375	0.000
M21.7 Unequal limb length (acquired)	0.625	0.375	0.000
M50.9 Cervical disk disorder, unspecified	0.625	0.375	0.000
I24.8 Other forms of acute ischaemic heart disease	0.000	0.375	0.625
I52 Other heart disorders in diseases classified elsewhere	0.000	0.376	0.624
I48 Atrial fibrillation and flutter	0.000	0.376	0.624
I43 Cardiomyopathy in diseases classified elsewhere	0.000	0.376	0.624
I41 Myocarditis in diseases classified elsewhere	0.000	0.376	0.624
I40 Acute myocarditis	0.000	0.376	0.624
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.000	0.376	0.624
I32 Pericarditis in diseases classified elsewhere	0.000	0.376	0.624
M13.90 Arthritis, unspecified (Multiple sites)	0.623	0.377	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.623	0.377	0.000
I20.1 Angina pectoris with documented spasm	0.000	0.378	0.622
M54.8 Other dorsalgia	0.621	0.378	0.000
M54.0 Panniculitis affecting regions of neck and back	0.621	0.378	0.000
I37 Pulmonary valve disorders	0.000	0.379	0.621
M22.1 Recurrent subluxation of patella	0.621	0.379	0.000
M22.9 Disorder of patella, unspecified	0.621	0.379	0.000
M22.3 Other derangements of patella	0.621	0.379	0.000
M22.0 Recurrent dislocation of patella	0.621	0.379	0.000
I00-I02 Acute rheumatic fever	0.000	0.379	0.621
M13.89 Other specified arthritis (Site unspecified)	0.620	0.379	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.380	0.620
M13.0 Polyarthritis, unspecified	0.619	0.381	0.000
M13.93 Arthritis, unspecified (Forearm)	0.619	0.381	0.000
M10.9 Gout, unspecified	0.619	0.381	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.618	0.382	0.000
M20 Acquired deformities of fingers and toes	0.613	0.387	0.000
M21.6 Other acquired deformities of ankle and foot	0.611	0.389	0.000
M41 Scoliosis	0.610	0.390	0.000
M93 Other osteochondropathies	0.609	0.391	0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)	0.608	0.392	0.000
M48.05 Spinal stenosis (Thoracolumbar region)	0.608	0.392	0.000
M48.04 Spinal stenosis (Thoracic region)	0.608	0.392	0.000
M48.03 Spinal stenosis (Cervicothoracic region)	0.608	0.392	0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)	0.608	0.392	0.000
M13.91 Arthritis, unspecified (Shoulder region)	0.608	0.392	0.000
M62.8 Other specified disorders of muscle	0.606	0.393	0.000
M24.0 Loose body in joint	0.606	0.394	0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.605	0.394	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.395	0.605
M13.80 Other specified arthritis (Multiple sites)	0.604	0.396	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.604	0.396	0.000
M61 Calcification and ossification of muscle	0.604	0.396	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.603	0.397	0.000
M13.92 Arthritis, unspecified (Upper arm)	0.603	0.397	0.000
M48.59 Collapsed vertebra, not elsewhere classified (Site unspecified)	0.602	0.397	0.000
M48.58 Collapsed vertebra, not elsewhere classified (Sacral and sacrococcygeal region)	0.602	0.397	0.000
M48.57 Collapsed vertebra, not elsewhere classified (Lumbosacral region)	0.602	0.397	0.000
M48.55 Collapsed vertebra, not elsewhere classified (Thoracolumbar region)	0.602	0.397	0.000
M48.53 Collapsed vertebra, not elsewhere classified (Cervicothoracic region)	0.602	0.397	0.000
M48.52 Collapsed vertebra, not elsewhere classified (Cervical region)	0.602	0.397	0.000
M48.51 Collapsed vertebra, not elsewhere classified (Occipito-atlanto-axial region)	0.602	0.397	0.000
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)	0.602	0.397	0.000
I47 Paroxysmal tachycardia	0.000	0.398	0.602
M50.0 Cervical disk disorder with myelopathy	0.602	0.398	0.000
M66 Spontaneous rupture of synovium and tendon	0.601	0.398	0.000
M54.50 Low back pain (Multiple sites in spine)	0.601	0.399	0.000
M47.0 Anterior spinal and vertebral artery compression syndromes	0.601	0.399	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.599	0.401	0.000
M47.2 Other spondylosis with radiculopathy	0.597	0.403	0.000
M10.0 Idiopathic gout	0.597	0.403	0.000
M54.19 Radiculopathy (Site unspecified)	0.597	0.403	0.000
M40 Kyphosis and lordosis	0.595	0.405	0.000
M05.8 Other seropositive rheumatoid arthritis	0.594	0.405	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.594	0.405	0.000
M05.2 Rheumatoid vasculitis	0.594	0.405	0.000
M05.1 Rheumatoid lung disease	0.594	0.405	0.000
M05.0 Felty's syndrome	0.594	0.405	0.000
I50 Heart failure	0.000	0.406	0.594
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.592	0.408	0.000
M21.24 Flexion deformity (Hand)	0.587	0.413	0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.587	0.413	0.000
M35 Other systemic involvement of connective tissue	0.585	0.415	0.000
M70-M79 Other soft tissue disorders	0.583	0.417	0.000
M54.28 Cervicalgia-Sacral/sacrococ	0.583	0.417	0.000
M54.27 Cervicalgia-Lumbosacral	0.583	0.417	0.000
M54.26 Cervicalgia-Lumbar	0.583	0.417	0.000
M54.25 Cervicalgia-Thoracolumbar	0.583	0.417	0.000
M54.24 Cervicalgia-Thoracic	0.583	0.417	0.000
M54.23 Cervicalgia (Cervicothoracic region)	0.583	0.417	0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.583	0.417	0.000
M54.20 Cervicalgia-Mult site	0.583	0.417	0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.580	0.420	0.000
M54.57 Low back pain (Lumbosacral region)	0.580	0.420	0.000
M11.26 Other chondrocalcinosis (Lower leg)	0.578	0.422	0.000
I44 Atrioventricular and left bundle-branch block	0.000	0.423	0.577
M11.9 Crystal arthropathy, unspecified	0.576	0.424	0.000
M11.8 Other specified crystal arthropathies	0.576	0.424	0.000
M11.1 Familial chondrocalcinosis	0.576	0.424	0.000
M11.0 Hydroxyapatite deposition disease	0.576	0.424	0.000
M21.27 Flexion deformity (Ankle and foot)	0.574	0.426	0.000
M31 Other necrotising vasculopathies	0.573	0.427	0.000
M20.1 Hallux valgus (acquired)	0.573	0.427	0.000
I28 Other diseases of pulmonary vessels	0.000	0.429	0.571
M65.1 Other infective (teno)synovitis	0.571	0.429	0.000
I08 Multiple valve diseases	0.000	0.429	0.570
I31.9 Disease of pericardium, unspecified	0.000	0.430	0.570
M80-M85 Disorders of bone density and structure	0.566	0.434	0.000
I30 Acute pericarditis	0.000	0.434	0.566
M22.2 Patellofemoral disorders	0.564	0.436	0.000
M49.5 Collapsed vertebra in diseases classified elsewhere	0.564	0.436	0.000
M10.4 Other secondary gout	0.564	0.436	0.000
M10.3 Gout due to impairment of renal function	0.564	0.436	0.000
M10.2 Drug-induced gout	0.564	0.436	0.000
M10.1 Lead-induced gout	0.564	0.436	0.000
M50.8 Other cervical disk disorders	0.563	0.437	0.000
M47.85 Other spondylosis (Thoracolumbar region)	0.561	0.439	0.000
M47.84 Other spondylosis (Thoracic region)	0.561	0.439	0.000
M47.83 Other spondylosis (Cervicothoracic region)	0.561	0.439	0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)	0.561	0.439	0.000
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.560	0.440	0.000
M21.18 Varus deformity, not elsewhere classified (Other)	0.560	0.440	0.000
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.560	0.440	0.000
M21.14 Varus deformity, not elsewhere classified (Hand)	0.560	0.440	0.000
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.560	0.440	0.000
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.560	0.440	0.000
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.560	0.440	0.000
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.560	0.440	0.000
I51.7 Cardiomegaly	0.000	0.441	0.559
M65.8 Other synovitis and tenosynovitis	0.559	0.441	0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.556	0.444	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.000	0.448	0.552
I36 Nonrheumatic tricuspid valve disorders	0.000	0.449	0.550
I33 Acute and subacute endocarditis	0.000	0.450	0.550
I47.1 Supraventricular tachycardia	0.000	0.450	0.550
I25.4 Coronary artery aneurysm	0.000	0.450	0.549
M42 Spinal osteochondrosis	0.548	0.451	0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)	0.548	0.452	0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)	0.545	0.455	0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.545	0.455	0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.545	0.455	0.000
M54.92 Dorsalgia, unspecified (Cervical region)	0.545	0.455	0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.545	0.455	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.545	0.455	0.000
M92 Other juvenile osteochondrosis	0.544	0.455	0.000
M99 Biomechanical lesions, not elsewhere classified	0.544	0.456	0.000
M13.88 Other specified arthritis (Other)	0.543	0.457	0.000
M13.87 Other specified arthritis (Ankle and foot)	0.543	0.457	0.000
M13.86 Other specified arthritis (Lower leg)	0.543	0.457	0.000
M13.85 Other specified arthritis (Pelvic region and thigh)	0.543	0.457	0.000
M13.84 Other specified arthritis (Hand)	0.543	0.457	0.000
M13.83 Other specified arthritis (Forearm)	0.543	0.457	0.000
M13.82 Other specified arthritis (Upper arm)	0.543	0.457	0.000
M13.81 Other specified arthritis (Shoulder region)	0.543	0.457	0.000
I46.1 Sudden cardiac death, so described	0.000	0.458	0.541
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.540	0.459	0.000
M24.26 Disorder of ligament (Lower leg)	0.539	0.460	0.000
M13.98 Arthritis, unspecified (Other)	0.539	0.461	0.000
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)	0.539	0.461	0.000
M45 Ankylosing spondylitis	0.538	0.462	0.000
M65.2 Calcific tendinitis	0.537	0.463	0.000
M65.0 Abscess of tendon sheath	0.537	0.463	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.536	0.464	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.536	0.464	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.536	0.464	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.536	0.464	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.536	0.464	0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.536	0.464	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.536	0.464	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.535	0.465	0.000
I51.4 Myocarditis, unspecified	0.000	0.465	0.535
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.534	0.466	0.000
M89.9 Disorder of bone, unspecified	0.534	0.466	0.000
M47.89 Other spondylosis (Site unspecified)	0.533	0.467	0.000
M60.9 Myositis, unspecified	0.532	0.468	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.000	0.468	0.531
M24.29 Disorder of ligament (Site unspecified)	0.531	0.469	0.000
M24.28 Disorder of ligament (Other)	0.531	0.469	0.000
M24.25 Disorder of ligament (Pelvic region and thigh)	0.531	0.469	0.000
M24.22 Disorder of ligament (Upper arm)	0.531	0.469	0.000
M24.20 Disorder of ligament (Multiple sites)	0.531	0.469	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.530	0.470	0.000
M49.8 Spondylopathy in other diseases classified elsewhere	0.530	0.470	0.000
M49.4 Neuropathic spondylopathy	0.530	0.470	0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.530	0.470	0.000
M49.2 Enterobacterial spondylitis	0.530	0.470	0.000
M49.1 Brucella spondylitis	0.530	0.470	0.000
M49.0 Tuberculosis of spine	0.530	0.470	0.000
M47.86 Other spondylosis (Lumbar region)	0.527	0.473	0.000
I50.1 Left ventricular failure	0.000	0.474	0.526
M20.3 Other deformity of hallux (acquired)	0.526	0.474	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.525	0.474	0.000
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)	0.524	0.476	0.000
M21.29 Flexion deformity (Site unspecified)	0.521	0.479	0.000
M21.28 Flexion deformity (Other)	0.521	0.479	0.000
M21.25 Flexion deformity (Pelvic region and thigh)	0.521	0.479	0.000
M21.23 Flexion deformity (Forearm)	0.521	0.479	0.000
M21.22 Flexion deformity (Upper arm)	0.521	0.479	0.000
M21.21 Flexion deformity (Shoulder region)	0.521	0.479	0.000
M21.20 Flexion deformity (Multiple sites)	0.521	0.479	0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.520	0.480	0.000
M21.26 Flexion deformity (Lower leg)	0.519	0.481	0.000
I51.5 Myocardial degeneration	0.000	0.481	0.519
I51.3 Intracardiac thrombosis, not elsewhere classified	0.000	0.481	0.519
I51.2 Rupture of papillary muscle, not elsewhere classified	0.000	0.481	0.519
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.000	0.481	0.519
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.518	0.482	0.000
I51.6 Cardiovascular disease, unspecified	0.000	0.482	0.518
M54.49 Lumbago with sciatica (Site unspecified)	0.517	0.483	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.517	0.483	0.000
M53.9 Dorsopathy, unspecified	0.516	0.483	0.000
M53.8 Other specified dorsopathies	0.516	0.483	0.000
M53.2 Spinal instabilities	0.516	0.483	0.000
M53.1 Cervicobrachial syndrome	0.516	0.483	0.000
M53.0 Cervicocranial syndrome	0.516	0.483	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.514	0.486	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.514	0.486	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.514	0.486	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.514	0.486	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.514	0.486	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.514	0.486	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.514	0.486	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.514	0.486	0.000
M54.6 Pain in thoracic spine	0.514	0.486	0.000
I23.8 Other current complications following acute myocardial infarction	0.000	0.486	0.514
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.000	0.486	0.514
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.000	0.486	0.514
M24.27 Disorder of ligament (Ankle and foot)	0.514	0.486	0.000
M89.0 Algoneurodystrophy	0.513	0.487	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.000	0.487	0.513
M65.4 Radial styloid tenosynovitis [de Quervain]	0.512	0.488	0.000
M93.9 Osteochondropathy, unspecified	0.511	0.489	0.000
M06.34 Rheumatoid nodule (Hand)	0.511	0.489	0.000
M24.24 Disorder of ligament (Hand)	0.510	0.490	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.510	0.490	0.000
M08.9 Juvenile arthritis, unspecified	0.507	0.493	0.000
M08.8 Other juvenile arthritis	0.507	0.493	0.000
M08.4 Pauciarticular juvenile arthritis	0.507	0.493	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.507	0.493	0.000
M08.2 Juvenile arthritis with systemic onset	0.507	0.493	0.000
M08.1 Juvenile ankylosing spondylitis	0.507	0.493	0.000
M08.0 Juvenile rheumatoid arthritis	0.507	0.493	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.507	0.493	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.507	0.493	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.507	0.493	0.000
M09.0 Juvenile arthritis in psoriasis	0.507	0.493	0.000
M12.8 Other specific arthropathies, not elsewhere classified	0.507	0.493	0.000
M12.5 Traumatic arthropathy	0.507	0.493	0.000
M12.4 Intermittent hydrarthrosis	0.507	0.493	0.000
M12.3 Palindromic rheumatism	0.507	0.493	0.000
M12.2 Villonodular synovitis (pigmented)	0.507	0.493	0.000
M12.1 Kaschin-Beck disease	0.507	0.493	0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.507	0.493	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.506	0.493	0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.506	0.493	0.000
M30.2 Juvenile polyarteritis	0.506	0.493	0.000
M30.0 Polyarteritis nodosa	0.506	0.493	0.000
M21.39 Wrist or foot drop (acquired)-Site unspec	0.506	0.494	0.000
M21.38 Wrist or foot drop (acquired)-Other	0.506	0.494	0.000
M21.36 Wrist or foot drop (acquired)-Lower leg	0.506	0.494	0.000
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.506	0.494	0.000
M21.34 Wrist or foot drop (acquired) (Hand)	0.506	0.494	0.000
M21.33 Wrist or foot drop (acquired) (Forearm)	0.506	0.494	0.000
M21.32 Wrist or foot drop (acquired)-Upper arm	0.506	0.494	0.000
M21.31 Wrist or foot drop (acquired)-Shldr region	0.506	0.494	0.000
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.506	0.494	0.000
M47.87 Other spondylosis (Lumbosacral region)	0.506	0.494	0.000
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)	0.506	0.494	0.000
M62.9 Disorder of muscle, unspecified	0.505	0.495	0.000
M62.6 Muscle strain	0.505	0.495	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.505	0.495	0.000
M62.4 Contracture of muscle	0.505	0.495	0.000
M62.3 Immobility syndrome (paraplegic)	0.505	0.495	0.000
M62.2 Ischaemic infarction of muscle	0.505	0.495	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.505	0.495	0.000
M62.0 Diastasis of muscle	0.505	0.495	0.000
M07.6 Other enteropathic arthropathies	0.505	0.495	0.000
M07.5 Arthropathy in ulcerative colitis	0.505	0.495	0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.505	0.495	0.000
M07.2 Psoriatic spondylitis	0.505	0.495	0.000
M07.1 Arthritis mutilans	0.505	0.495	0.000
M07.0 Distal interphalangeal psoriatic arthropathy	0.505	0.495	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.505	0.495	0.000
M06.38 Rheumatoid nodule (Other)	0.505	0.495	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.505	0.495	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.505	0.495	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.505	0.495	0.000
M06.33 Rheumatoid nodule (Forearm)	0.505	0.495	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.505	0.495	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.505	0.495	0.000
M06.30 Rheumatoid nodule (Multiple sites)	0.505	0.495	0.000
M54.17 Radiculopathy (Lumbosacral region)	0.504	0.496	0.000
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)	0.504	0.496	0.000
M65.98 Synovitis and tenosynovitis, unspecified (Other)	0.504	0.496	0.000
M71 Other bursopathies	0.502	0.498	0.000
M89.3 Hypertrophy of bone	0.502	0.498	0.000
M07.3 Other psoriatic arthropathies	0.502	0.498	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.500	0.500	0.000
M06.18 Adult-onset Still's disease (Other)	0.500	0.500	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.500	0.500	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.500	0.500	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.500	0.500	0.000
M06.14 Adult-onset Still's disease (Hand)	0.500	0.500	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.500	0.500	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations