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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs735883
log Bayes Factor = 97.4857
Chromosome 6   position 32,816,054  (GRCh37) Explore rs735883 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
M05-M14 Inflammatory polyarthropathies
1.000 0.000 0.000
M06 Other rheumatoid arthritis
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
1.000 0.000 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
1.000 0.000 0.000
M05 Seropositive rheumatoid arthritis
1.000 0.000 0.000
E10.1 With ketoacidosis
0.999 0.001 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.999 0.001 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.999 0.001 0.000
E11.9 Without complications
0.997 0.003 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.996 0.004 0.000
M20-M25 Other joint disorders
0.996 0.004 0.000
M35.3 Polymyalgia rheumatica
0.996 0.004 0.000
M35 Other systemic involvement of connective tissue
0.996 0.004 0.000
E14 Unspecified diabetes mellitus
0.995 0.005 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.995 0.005 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.995 0.005 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.987 0.013 0.000
M31 Other necrotising vasculopathies
0.984 0.016 0.000
E10.4 With neurological complications
0.983 0.017 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.978 0.022 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.977 0.023 0.000
M06.3 Rheumatoid nodule
0.975 0.025 0.000
J45.9 Asthma, unspecified
0.973 0.027 0.000
E10.2 With renal complications
0.967 0.033 0.000
E14.3 With ophthalmic complications
0.967 0.033 0.000
E16 Other disorders of pancreatic internal secretion
0.962 0.038 0.000
E11.2 With renal complications
0.959 0.041 0.000
D50.9 Iron deficiency anaemia, unspecified
0.948 0.052 0.000
E16.2 Hypoglycaemia, unspecified
0.948 0.052 0.000
D50 Iron deficiency anaemia
0.946 0.054 0.000
D50-D53 Nutritional anaemias
0.939 0.061 0.000
M31.6 Other giant cell arteritis
0.934 0.066 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.929 0.071 0.000
E10.8 With unspecified complications
0.928 0.072 0.000
D64.9 Anaemia, unspecified
0.926 0.074 0.000
D60-D64 Aplastic and other anaemias
0.924 0.076 0.000
D64 Other anaemias
0.924 0.076 0.000
E14.9 Without complications
0.921 0.079 0.000
M60-M63 Disorders of muscles
0.911 0.089 0.000
D50.8 Other iron deficiency anaemias
0.908 0.092 0.000
M40-M43 Deforming dorsopathies
0.906 0.094 0.000
E06 Thyroiditis
0.905 0.095 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.897 0.103 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.896 0.104 0.000
M35.7 Hypermobility syndrome
0.893 0.107 0.000
M30 Polyarteritis nodosa and related conditions
0.887 0.113 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.880 0.120 0.000
M34 Systemic sclerosis
0.874 0.126 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.873 0.127 0.000
M05.8 Other seropositive rheumatoid arthritis
0.866 0.134 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.865 0.135 0.000
E10.0 With coma
0.859 0.141 0.000
E11.6 With other specified complications
0.858 0.142 0.000
M10 Gout
0.854 0.146 0.000
E10.6 With other specified complications
0.853 0.147 0.000
E11.8 With unspecified complications
0.851 0.149 0.000
M43 Other deforming dorsopathies
0.850 0.150 0.000
E14.6 With other specified complications
0.849 0.151 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.841 0.159 0.000
E11.3 With ophthalmic complications
0.838 0.162 0.000
D80-D89 Certain disorders involving the immune mechanism
0.831 0.169 0.000
D53 Other nutritional anaemias
0.830 0.170 0.000
M06.34 Rheumatoid nodule (Hand)
0.824 0.176 0.000
M43.1 Spondylolisthesis
0.817 0.183 0.000
M60 Myositis
0.816 0.184 0.000
E11.1 With ketoacidosis
0.814 0.186 0.000
M32 Systemic lupus erythematosus
0.813 0.187 0.000
M12 Other specific arthropathies
0.810 0.189 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.810 0.190 0.000
E20-E35 Disorders of other endocrine glands
0.807 0.193 0.000
E10.5 With peripheral circulatory complications
0.802 0.198 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.799 0.200 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.798 0.202 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.794 0.205 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.791 0.209 0.000
M86-M90 Other osteopathies
0.790 0.210 0.000
E06.3 Autoimmune thyroiditis
0.789 0.211 0.000
E14.1 With ketoacidosis
0.788 0.212 0.000
M08 Juvenile arthritis
0.788 0.212 0.000
M05.1 Rheumatoid lung disease
0.785 0.215 0.000
M21 Other acquired deformities of limbs
0.784 0.216 0.000
E10.7 With multiple complications
0.783 0.217 0.000
E23 Hypofunction and other disorders of pituitary gland
0.783 0.217 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.780 0.220 0.000
M30.0 Polyarteritis nodosa
0.780 0.220 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.777 0.223 0.000
M35.1 Other overlap syndromes
0.777 0.223 0.000
M43.16 Spondylolisthesis (Lumbar region)
0.776 0.224 0.000
M14 Arthropathies in other diseases classified elsewhere
0.772 0.228 0.000
M31.3 Wegener's granulomatosis
0.771 0.229 0.000
M06.4 Inflammatory polyarthropathy
0.769 0.231 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.766 0.234 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.758 0.242 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.757 0.243 0.000
D53.9 Nutritional anaemia, unspecified
0.752 0.247 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.752 0.248 0.000
M21.0 Valgus deformity, not elsewhere classified
0.750 0.250 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.748 0.252 0.000
M31.7 Microscopic polyangiitis
0.747 0.253 0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.747 0.253 0.000
M62 Other disorders of muscle
0.746 0.254 0.000
M80-M85 Disorders of bone density and structure
0.745 0.255 0.000
E14.2 Withrenal complications
0.745 0.255 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.744 0.256 0.000
M31.9 Necrotising vasculopathy, unspecified
0.743 0.257 0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.742 0.258 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.736 0.264 0.000
E23.7 Disorder of pituitary gland, unspecified
0.734 0.266 0.000
M65-M68 Disorders of synovium and tendon
0.734 0.266 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.732 0.268 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.731 0.269 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.731 0.269 0.000
E14.5 With peripheral circulatory complications
0.726 0.274 0.000
M06.8 Other specified rheumatoid arthritis
0.724 0.275 0.000
M34.8 Other forms of systemic sclerosis
0.724 0.276 0.000
M10.0 Idiopathic gout
0.723 0.277 0.000
M91-M94 Chondropathies
0.719 0.281 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
M06.2 Rheumatoid bursitis
0.717 0.283 0.000
M06.1 Adult-onset Still's disease
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E11.7 With multiple complications
0.717 0.283 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.717 0.283 0.000
M05.2 Rheumatoid vasculitis
0.717 0.283 0.000
M05.0 Felty's syndrome
0.717 0.283 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.716 0.284 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.716 0.284 0.000
E06.5 Other chronic thyroiditis
0.716 0.284 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.714 0.286 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.714 0.286 0.000
M35.5 Multifocal fibrosclerosis
0.714 0.286 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.714 0.286 0.000
E14.7 With multiple complications
0.713 0.287 0.000
E14.0 With coma
0.713 0.287 0.000
E03.1 Congenital hypothyroidism without goitre
0.711 0.289 0.000
D50.1 Sideropenic dysphagia
0.710 0.290 0.000
E23.2 Diabetes insipidus
0.710 0.290 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.709 0.291 0.000
M31.0 Hypersensitivity angiitis
0.708 0.292 0.000
M34.0 Progressive systemic sclerosis
0.706 0.294 0.000
M31.2 Lethal midline granuloma
0.705 0.295 0.000
M60.9 Myositis, unspecified
0.704 0.296 0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.704 0.296 0.000
E11.4 With neurological complications
0.703 0.297 0.000
M00-M03 Infectious arthropathies
0.703 0.297 0.000
E15 Nondiabetic hypoglycaemic coma
0.701 0.299 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.699 0.301 0.000
M06.38 Rheumatoid nodule (Other)
0.699 0.301 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.699 0.301 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.699 0.301 0.000
M06.33 Rheumatoid nodule (Forearm)
0.699 0.301 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.699 0.301 0.000
E03.8 Other specified hypothyroidism
0.697 0.303 0.000
E06.9 Thyroiditis, unspecified
0.692 0.308 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.692 0.308 0.000
M31.8 Other specified necrotising vasculopathies
0.692 0.308 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.690 0.310 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.690 0.310 0.000
E16.4 Abnormal secretion of gastrin
0.690 0.310 0.000
E16.3 Increased secretion of glucagon
0.690 0.310 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.688 0.312 0.000
E13 Other specified diabetes mellitus
0.688 0.312 0.000
M87 Osteonecrosis
0.680 0.320 0.000
D86 Sarcoidosis
0.679 0.321 0.000
E16.1 Other hypoglycaemia
0.678 0.322 0.000
D84 Other immunodeficiencies
0.676 0.324 0.000
M21.4 Flat foot [pes planus] (acquired)
0.674 0.326 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.672 0.328 0.000
E14.4 With neurological complications
0.672 0.328 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.669 0.331 0.000
D63.8 Anaemia in other chronic diseases classified elsewhere
0.669 0.331 0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.668 0.332 0.000
M34.9 Systemic sclerosis, unspecified
0.668 0.332 0.000
D80 Immunodeficiency with predominantly antibody defects
0.667 0.333 0.000
M43.9 Deforming dorsopathy, unspecified
0.667 0.333 0.000
# Top node
0.666 0.334 0.000
D82 Immunodeficiency associated with other major defects
0.664 0.335 0.000
D64.4 Congenital dyserythropoietic anaemia
0.662 0.337 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.662 0.337 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.662 0.337 0.000
D64.0 Hereditary sideroblastic anaemia
0.662 0.337 0.000
M82 Osteoporosis in diseases classified elsewhere
0.662 0.338 0.000
M10.9 Gout, unspecified
0.662 0.338 0.000
D51 Vitamin B12 deficiency anaemia
0.658 0.342 0.000
E06.1 Subacute thyroiditis
0.658 0.342 0.000
M41 Scoliosis
0.656 0.344 0.000
M12.3 Palindromic rheumatism
0.654 0.345 0.000
M80 Osteoporosis with pathological fracture
0.654 0.345 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.653 0.347 0.000
M61 Calcification and ossification of muscle
0.653 0.347 0.000
M42 Spinal osteochondrosis
0.650 0.350 0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.649 0.351 0.000
E06.4 Drug-induced thyroiditis
0.649 0.351 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.649 0.351 0.000
E06.0 Acute thyroiditis
0.649 0.351 0.000
E23.6 Other disorders of pituitary gland
0.648 0.352 0.000
E20 Hypoparathyroidism
0.640 0.360 0.000
E29 Testicular dysfunction
0.638 0.362 0.000
D64.3 Other sideroblastic anaemias
0.638 0.362 0.000
M30.8 Other conditions related to polyarteritis nodosa
0.636 0.364 0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.636 0.364 0.000
M30.2 Juvenile polyarteritis
0.636 0.364 0.000
M06.0 Seronegative rheumatoid arthritis
0.636 0.364 0.000
M08.0 Juvenile rheumatoid arthritis
0.635 0.365 0.000
M12.5 Traumatic arthropathy
0.635 0.365 0.000
M62.8 Other specified disorders of muscle
0.632 0.368 0.000
M05.19 Rheumatoid lung disease (Site unspecified)
0.631 0.369 0.000
M10.96 Gout, unspecified (Lower leg)
0.630 0.370 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.629 0.371 0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified
0.628 0.372 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.626 0.374 0.000
M32.0 Drug-induced systemic lupus erythematosus
0.626 0.374 0.000
M67 Other disorders of synovium and tendon
0.625 0.375 0.000
M43.19 Spondylolisthesis (Site unspecified)
0.624 0.376 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.624 0.376 0.000
E14.8 With unspecified complications
0.624 0.376 0.000
M60.8 Other myositis
0.623 0.376 0.000
M05.88 Other seropositive rheumatoid arthritis (Other)
0.621 0.379 0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.621 0.379 0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.621 0.379 0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.621 0.379 0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.621 0.379 0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.621 0.379 0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.621 0.379 0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.621 0.379 0.000
M43.6 Torticollis
0.620 0.380 0.000
D61 Other aplastic anaemias
0.620 0.380 0.000
M34.1 CR(E)ST syndrome
0.618 0.382 0.000
M11 Other crystal arthropathies
0.618 0.382 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.617 0.383 0.000
M35.8 Other specified systemic involvement of connective tissue
0.617 0.383 0.000
M22 Disorders of patella
0.616 0.384 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.615 0.385 0.000
M43.10 Spondylolisthesis (Multiple sites in spine)
0.614 0.386 0.000
M10.4 Other secondary gout
0.613 0.387 0.000
M10.3 Gout due to impairment of renal function
0.613 0.387 0.000
M10.2 Drug-induced gout
0.613 0.387 0.000
M10.1 Lead-induced gout
0.613 0.387 0.000
M43.12 Spondylolisthesis (Cervical region)
0.610 0.390 0.000
M83 Adult osteomalacia
0.610 0.390 0.000
M43.8 Other specified deforming dorsopathies
0.609 0.390 0.000
M43.5 Other recurrent vertebral subluxation
0.609 0.390 0.000
M43.4 Other recurrent atlantoaxial subluxation
0.609 0.390 0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy
0.609 0.390 0.000
M60.0 Infective myositis
0.610 0.390 0.000
D52 Folate deficiency anaemia
0.607 0.393 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.606 0.394 0.000
D64.8 Other specified anaemias
0.605 0.395 0.000
M43.2 Other fusion of spine
0.604 0.396 0.000
M82.1 Osteoporosis in endocrine disorders
0.603 0.397 0.000
M40 Kyphosis and lordosis
0.602 0.398 0.000
D86.3 Sarcoidosis of skin
0.601 0.399 0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.599 0.401 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.599 0.401 0.000
D81 Combined immunodeficiencies
0.596 0.404 0.000
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot
0.595 0.405 0.000
E05.8 Other thyrotoxicosis
0.595 0.405 0.000
D53.8 Other specified nutritional anaemias
0.595 0.405 0.000
D53.2 Scorbutic anaemia
0.595 0.405 0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.595 0.405 0.000
D53.0 Protein deficiency anaemia
0.595 0.405 0.000
M90 Osteopathies in diseases classified elsewhere
0.595 0.405 0.000
E27 Other disorders of adrenal gland
0.593 0.407 0.000
M10.07 Idiopathic gout (Ankle and foot)
0.592 0.408 0.000
M31.1 Thrombotic microangiopathy
0.591 0.409 0.000
E11.0 With coma
0.591 0.409 0.000
M67.1 Other contracture of tendon (sheath)
0.590 0.410 0.000
M12.8 Other specific arthropathies, not elsewhere classified
0.587 0.413 0.000
M14.2 Diabetic arthropathy
0.587 0.413 0.000
E28 Ovarian dysfunction
0.587 0.413 0.000
E34 Other endocrine disorders
0.586 0.413 0.000
M43.18 Spondylolisthesis (Sacral and sacrococcygeal region)
0.586 0.414 0.000
M43.15 Spondylolisthesis (Thoracolumbar region)
0.586 0.414 0.000
M43.14 Spondylolisthesis (Thoracic region)
0.586 0.414 0.000
M43.13 Spondylolisthesis (Cervicothoracic region)
0.586 0.414 0.000
M43.11 Spondylolisthesis (Occipito-atlanto-axial region)
0.586 0.414 0.000
M60.1 Interstitial myositis
0.585 0.415 0.000
M21.8 Other specified acquired deformities of limbs
0.585 0.415 0.000
M13 Other arthritis
0.584 0.416 0.000
M66 Spontaneous rupture of synovium and tendon
0.584 0.416 0.000
M32.9 Systemic lupus erythematosus, unspecified
0.583 0.417 0.000
M12.4 Intermittent hydrarthrosis
0.581 0.419 0.000
M12.1 Kaschin-Beck disease
0.581 0.419 0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.581 0.419 0.000
M14.6 Neuropathic arthropathy
0.579 0.421 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.578 0.421 0.000
E32 Diseases of thymus
0.578 0.421 0.000
E30 Disorders of puberty, not elsewhere classified
0.578 0.421 0.000
M87.2 Osteonecrosis due to previous trauma
0.578 0.422 0.000
M06.46 Inflammatory polyarthropathy (Lower leg)
0.577 0.423 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.576 0.424 0.000
E27.1 Primary adrenocortical insufficiency
0.576 0.424 0.000
E50-E64 Other nutritional deficiencies
0.576 0.424 0.000
M62.6 Muscle strain
0.575 0.425 0.000
M92 Other juvenile osteochondrosis
0.573 0.427 0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.573 0.427 0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.572 0.428 0.000
D55-D59 Haemolytic anaemias
0.570 0.430 0.000
D84.1 Defects in the complement system
0.569 0.431 0.000
M10.06 Idiopathic gout (Lower leg)
0.569 0.431 0.000
M07 Psoriatic and enteropathic arthropathies
0.568 0.432 0.000
E31 Polyglandular dysfunction
0.567 0.433 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.566 0.434 0.000
M62.2 Ischaemic infarction of muscle
0.565 0.435 0.000
M08.9 Juvenile arthritis, unspecified
0.565 0.435 0.000
M08.8 Other juvenile arthritis
0.565 0.435 0.000
M08.4 Pauciarticular juvenile arthritis
0.565 0.435 0.000
M08.3 Juvenile polyarthritis (seronegative)
0.565 0.435 0.000
M08.2 Juvenile arthritis with systemic onset
0.565 0.435 0.000
M08.1 Juvenile ankylosing spondylitis
0.565 0.435 0.000
M05.18 Rheumatoid lung disease (Other)
0.563 0.437 0.000
M05.17 Rheumatoid lung disease (Ankle and foot)
0.563 0.437 0.000
M05.16 Rheumatoid lung disease (Lower leg)
0.563 0.437 0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.563 0.437 0.000
M05.14 Rheumatoid lung disease (Hand)
0.563 0.437 0.000
M05.13 Rheumatoid lung disease (Forearm)
0.563 0.437 0.000
M05.12 Rheumatoid lung disease (Upper arm)
0.563 0.437 0.000
M05.11 Rheumatoid lung disease (Shoulder region)
0.563 0.437 0.000
M05.10 Rheumatoid lung disease (Multiple sites)
0.563 0.437 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.561 0.438 0.000
E23.1 Drug-induced hypopituitarism
0.561 0.438 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.561 0.439 0.000
Q43 Other congenital malformations of intestine
0.559 0.441 0.000
M93 Other osteochondropathies
0.558 0.442 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.557 0.443 0.000
E24 Cushing's syndrome
0.554 0.446 0.000
M14.8 Arthropathies in other specified diseases classified elsewhere
0.553 0.446 0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.553 0.446 0.000
M14.4 Arthropathy in amyloidosis
0.553 0.446 0.000
M14.3 Lipoid dermatoarthritis
0.553 0.446 0.000
M14.1 Crystal arthropathy in other metabolic disorders
0.553 0.446 0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.553 0.446 0.000
M82.10 Osteoporosis in endocrine disorders (Multiple sites)
0.553 0.447 0.000
M06.48 Inflammatory polyarthropathy (Other)
0.551 0.449 0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.551 0.449 0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.551 0.449 0.000
M06.44 Inflammatory polyarthropathy (Hand)
0.551 0.449 0.000
M06.43 Inflammatory polyarthropathy (Forearm)
0.551 0.449 0.000
M06.42 Inflammatory polyarthropathy (Upper arm)
0.551 0.449 0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.551 0.449 0.000
D83 Common variable immunodeficiency
0.550 0.450 0.000
M99 Biomechanical lesions, not elsewhere classified
0.549 0.451 0.000
M86 Osteomyelitis
0.548 0.452 0.000
M62.0 Diastasis of muscle
0.546 0.453 0.000
M32.8 Other forms of systemic lupus erythematosus
0.546 0.454 0.000
D82.1 Di George's syndrome
0.545 0.455 0.000
K90 Intestinal malabsorption
0.545 0.455 0.000
M10.04 Idiopathic gout (Hand)
0.543 0.457 0.000
M12.2 Villonodular synovitis (pigmented)
0.542 0.458 0.000
D86.9 Sarcoidosis, unspecified
0.542 0.458 0.000
M89 Other disorders of bone
0.542 0.458 0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere
0.541 0.459 0.000
M02 Reactive arthropathies
0.539 0.460 0.000
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)
0.537 0.462 0.000
M21.08 Valgus deformity, not elsewhere classified (Other)
0.537 0.462 0.000
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)
0.537 0.462 0.000
M21.04 Valgus deformity, not elsewhere classified (Hand)
0.537 0.462 0.000
M21.03 Valgus deformity, not elsewhere classified (Forearm)
0.537 0.462 0.000
M21.02 Valgus deformity, not elsewhere classified (Upper arm)
0.537 0.462 0.000
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)
0.537 0.462 0.000
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)
0.537 0.462 0.000
M87.8 Other osteonecrosis
0.537 0.463 0.000
M10.90 Gout, unspecified (Multiple sites)
0.537 0.463 0.000
M62.81 Other specified disorders of muscle (Shoulder region)
0.536 0.464 0.000
M43.99 Deforming dorsopathy, unspecified (Site unspecified)
0.536 0.464 0.000
M62.4 Contracture of muscle
0.535 0.465 0.000
M62.3 Immobility syndrome (paraplegic)
0.535 0.465 0.000
D61.1 Drug-induced aplastic anaemia
0.535 0.465 0.000
M12.39 Palindromic rheumatism (Site unspecified)
0.533 0.467 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.529 0.471 0.000
M22.9 Disorder of patella, unspecified
0.528 0.472 0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.527 0.473 0.000
M66.0 Rupture of popliteal cyst
0.527 0.473 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.526 0.474 0.000
D86.8 Sarcoidosis of other and combined sites
0.526 0.474 0.000
N04 Nephrotic syndrome
0.526 0.474 0.000
M41.4 Neuromuscular scoliosis
0.525 0.475 0.000
N04.9 Unspecified
0.524 0.476 0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere
0.524 0.476 0.000
M36.3 Arthropathy in other blood disorders
0.524 0.476 0.000
M36.2 Haemophilic arthropathy
0.524 0.476 0.000
M36.1 Arthropathy in neoplastic disease
0.524 0.476 0.000
M36.0 Dermato(poly)myositis in neoplastic disease
0.524 0.476 0.000
Q44.6 Cystic disease of liver
0.523 0.477 0.000
E20.9 Hypoparathyroidism, unspecified
0.521 0.479 0.000
M60.95 Myositis, unspecified (Pelvic region and thigh)
0.521 0.479 0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.519 0.480 0.000
M06.88 Other specified rheumatoid arthritis (Other)
0.519 0.480 0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.519 0.480 0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.519 0.480 0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.519 0.480 0.000
M06.84 Other specified rheumatoid arthritis (Hand)
0.519 0.480 0.000
M06.83 Other specified rheumatoid arthritis (Forearm)
0.519 0.480 0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.519 0.480 0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.519 0.480 0.000
M10.08 Idiopathic gout (Other)
0.518 0.481 0.000
M10.05 Idiopathic gout (Pelvic region and thigh)
0.518 0.481 0.000
M10.03 Idiopathic gout (Forearm)
0.518 0.481 0.000
M10.02 Idiopathic gout (Upper arm)
0.518 0.481 0.000
M10.01 Idiopathic gout (Shoulder region)
0.518 0.481 0.000
M10.00 Idiopathic gout (Multiple sites)
0.518 0.481 0.000
D60.9 Acquired pure red cell aplasia, unspecified
0.518 0.482 0.000
M13.8 Other specified arthritis
0.518 0.482 0.000
E29.1 Testicular hypofunction
0.517 0.483 0.000
N00-N08 Glomerular diseases
0.517 0.483 0.000
M87.0 Idiopathic aseptic necrosis of bone
0.516 0.484 0.000
E25 Adrenogenital disorders
0.515 0.485 0.000
M35.2 Behcet's disease
0.514 0.485 0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified
0.514 0.485 0.000
D63.1 Anaemia in other chronic diseases classified elsewhere
0.514 0.486 0.000
M06.19 Adult-onset Still's disease (Site unspecified)
0.514 0.486 0.000
M06.18 Adult-onset Still's disease (Other)
0.514 0.486 0.000
M06.17 Adult-onset Still's disease (Ankle and foot)
0.514 0.486 0.000
M06.16 Adult-onset Still's disease (Lower leg)
0.514 0.486 0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.514 0.486 0.000
M06.14 Adult-onset Still's disease (Hand)
0.514 0.486 0.000
M06.13 Adult-onset Still's disease (Forearm)
0.514 0.486 0.000
M06.12 Adult-onset Still's disease (Upper arm)
0.514 0.486 0.000
M06.11 Adult-onset Still's disease (Shoulder region)
0.514 0.486 0.000
M06.10 Adult-onset Still's disease (Multiple sites)
0.514 0.486 0.000
M06.29 Rheumatoid bursitis (Site unspecified)
0.514 0.486 0.000
M06.28 Rheumatoid bursitis (Other)
0.514 0.486 0.000
M06.27 Rheumatoid bursitis (Ankle and foot)
0.514 0.486 0.000
M06.26 Rheumatoid bursitis (Lower leg)
0.514 0.486 0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.514 0.486 0.000
M06.24 Rheumatoid bursitis (Hand)
0.514 0.486 0.000
M06.23 Rheumatoid bursitis (Forearm)
0.514 0.486 0.000
M06.22 Rheumatoid bursitis (Upper arm)
0.514 0.486 0.000
M06.21 Rheumatoid bursitis (Shoulder region)
0.514 0.486 0.000
M06.20 Rheumatoid bursitis (Multiple sites)
0.514 0.486 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.514 0.486 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.514 0.486 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.514 0.486 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.514 0.486 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.514 0.486 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.514 0.486 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.514 0.486 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.514 0.486 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.514 0.486 0.000
M09.2 Juvenile arthritis in ulcerative colitis
0.514 0.486 0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.514 0.486 0.000
M09.0 Juvenile arthritis in psoriasis
0.514 0.486 0.000
M22.3 Other derangements of patella
0.514 0.486 0.000
M05.09 Felty's syndrome (Site unspecified)
0.514 0.486 0.000
M05.08 Felty's syndrome (Other)
0.514 0.486 0.000
M05.07 Felty's syndrome (Ankle and foot)
0.514 0.486 0.000
M05.06 Felty's syndrome (Lower leg)
0.514 0.486 0.000
M05.05 Felty's syndrome (Pelvic region and thigh)
0.514 0.486 0.000
M05.04 Felty's syndrome (Hand)
0.514 0.486 0.000
M05.03 Felty's syndrome (Forearm)
0.514 0.486 0.000
M05.02 Felty's syndrome (Upper arm)
0.514 0.486 0.000
M05.01 Felty's syndrome (Shoulder region)
0.514 0.486 0.000
M05.00 Felty's syndrome (Multiple sites)
0.514 0.486 0.000
M05.29 Rheumatoid vasculitis (Site unspecified)
0.514 0.486 0.000
M05.28 Rheumatoid vasculitis (Other)
0.514 0.486 0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)
0.514 0.486 0.000
M05.26 Rheumatoid vasculitis (Lower leg)
0.514 0.486 0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)
0.514 0.486 0.000
M05.24 Rheumatoid vasculitis (Hand)
0.514 0.486 0.000
M05.23 Rheumatoid vasculitis (Forearm)
0.514 0.486 0.000
M05.22 Rheumatoid vasculitis (Upper arm)
0.514 0.486 0.000
M05.21 Rheumatoid vasculitis (Shoulder region)
0.514 0.486 0.000
M05.20 Rheumatoid vasculitis (Multiple sites)
0.514 0.486 0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)
0.514 0.486 0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)
0.514 0.486 0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)
0.514 0.486 0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)
0.514 0.486 0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)
0.514 0.486 0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)
0.514 0.486 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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