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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs743400
log Bayes Factor = 25.5334
Chromosome 6   position 31,607,111  (GRCh37) Explore rs743400 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.001 0.999
M05-M14 Inflammatory polyarthropathies
0.000 0.001 0.999
# Top node
0.000 0.005 0.995
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.006 0.994
E10.3 With ophthalmic complications
0.000 0.009 0.991
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.011 0.989
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.017 0.983
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.019 0.981
M07 Psoriatic and enteropathic arthropathies
0.000 0.022 0.978
L20-L30 Dermatitis and eczema
0.000 0.026 0.974
L57.0 Actinic keratosis
0.000 0.031 0.969
D60-D64 Aplastic and other anaemias
0.000 0.033 0.967
M07.3 Other psoriatic arthropathies
0.000 0.037 0.963
K90.0 Coeliac disease
0.961 0.039 0.000
Chapter X Diseases of the respiratory system
0.000 0.039 0.961
M06.0 Seronegative rheumatoid arthritis
0.000 0.045 0.955
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.049 0.951
L29 Pruritus
0.000 0.052 0.948
E10.1 With ketoacidosis
0.000 0.065 0.935
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.071 0.929
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.074 0.926
D50-D53 Nutritional anaemias
0.000 0.076 0.924
D64 Other anaemias
0.000 0.078 0.922
L08 Other local infections of skin and subcutaneous tissue
0.000 0.078 0.922
L29.0 Pruritus ani
0.000 0.081 0.919
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.082 0.918
M35.3 Polymyalgia rheumatica
0.000 0.083 0.917
M35 Other systemic involvement of connective tissue
0.000 0.084 0.916
E06 Thyroiditis
0.000 0.085 0.915
M20-M25 Other joint disorders
0.000 0.085 0.915
Chapter I Certain infectious and parasitic diseases
0.000 0.089 0.911
M05 Seropositive rheumatoid arthritis
0.000 0.095 0.905
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.095 0.905
D61 Other aplastic anaemias
0.000 0.095 0.905
L08.9 Local infection of skin and subcutaneous tissue, unspecified
0.000 0.096 0.904
J09-J18 Influenza and pneumonia
0.000 0.098 0.902
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.100 0.900
D64.9 Anaemia, unspecified
0.000 0.106 0.894
J81 Pulmonary oedema
0.000 0.118 0.882
E10.4 With neurological complications
0.000 0.124 0.876
D50 Iron deficiency anaemia
0.000 0.124 0.876
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.124 0.876
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.126 0.874
E10.5 With peripheral circulatory complications
0.000 0.127 0.873
J18 Pneumonia, organism unspecified
0.000 0.128 0.872
D80-D89 Certain disorders involving the immune mechanism
0.000 0.130 0.870
B35-B49 Mycoses
0.000 0.139 0.861
D68 Other coagulation defects
0.000 0.139 0.861
D61.9 Aplastic anaemia, unspecified
0.000 0.140 0.860
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.143 0.857
J18.1 Lobar pneumonia, unspecified
0.000 0.145 0.855
L40.0 Psoriasis vulgaris
0.000 0.146 0.854
E65-E68 Obesity and other hyperalimentation
0.000 0.148 0.851
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.151 0.849
E50-E64 Other nutritional deficiencies
0.000 0.151 0.849
E05.9 Thyrotoxicosis, unspecified
0.000 0.154 0.846
D50.9 Iron deficiency anaemia, unspecified
0.000 0.155 0.845
J40-J47 Chronic lower respiratory diseases
0.000 0.158 0.842
E06.3 Autoimmune thyroiditis
0.000 0.159 0.841
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.162 0.838
B37 Candidiasis
0.000 0.165 0.835
B25-B34 Other viral diseases
0.000 0.165 0.835
J80 Adult respiratory distress syndrome
0.000 0.167 0.833
B37.8 Candidiasis of other sites
0.000 0.172 0.828
E70-E90 Metabolic disorders
0.000 0.176 0.824
J47 Bronchiectasis
0.000 0.185 0.815
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.189 0.811
L27 Dermatitis due to substances taken internally
0.000 0.208 0.792
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.210 0.790
D86 Sarcoidosis
0.000 0.211 0.789
M14 Arthropathies in other diseases classified elsewhere
0.000 0.217 0.783
E20-E35 Disorders of other endocrine glands
0.000 0.217 0.783
J20-J22 Other acute lower respiratory infections
0.000 0.219 0.781
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.219 0.781
M34 Systemic sclerosis
0.000 0.224 0.776
D68.9 Coagulation defect, unspecified
0.000 0.228 0.772
E86 Volume depletion
0.000 0.230 0.770
E27 Other disorders of adrenal gland
0.000 0.236 0.764
L29.9 Pruritus, unspecified
0.000 0.238 0.762
A50-A64 Infections with a predominantly sexual mode of transmission
0.000 0.239 0.761
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.243 0.757
L28 Lichen simplex chronicus and prurigo
0.000 0.244 0.756
E66 Obesity
0.000 0.245 0.755
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.247 0.753
M31 Other necrotising vasculopathies
0.000 0.249 0.751
L02 Cutaneous abscess, furuncle and carbuncle
0.000 0.250 0.750
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.254 0.746
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.258 0.742
E66.8 Other obesity
0.000 0.262 0.738
B34 Viral infection of unspecified site
0.000 0.262 0.737
D55-D59 Haemolytic anaemias
0.000 0.263 0.737
J10 Influenza due to identified influenza virus
0.000 0.264 0.736
L43 Lichen planus
0.000 0.264 0.736
D68.5 Primary Thrombophilia
0.000 0.265 0.735
E04 Other non-toxic goitre
0.000 0.267 0.733
M35.7 Hypermobility syndrome
0.000 0.270 0.730
E53 Deficiency of other B group vitamins
0.000 0.271 0.729
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.279 0.721
C44.3 Skin of other and unspecified parts of face
0.000 0.280 0.720
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E10.2 With renal complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
L40.8 Other psoriasis
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
J18.9 Pneumonia, unspecified
0.000 0.284 0.716
D52 Folate deficiency anaemia
0.000 0.284 0.716
M12 Other specific arthropathies
0.000 0.284 0.716
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.284 0.716
M08 Juvenile arthritis
0.000 0.284 0.716
C44 Other malignant neoplasms of skin
0.000 0.284 0.716
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.285 0.715
J14 Pneumonia due to Haemophilus influenzae
0.000 0.286 0.714
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.286 0.714
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.291 0.709
L58 Radiodermatitis
0.000 0.291 0.709
L55 Sunburn
0.000 0.291 0.709
A00-A09 Intestinal infectious diseases
0.000 0.292 0.708
L29.2 Pruritus vulvae
0.000 0.292 0.708
E40-E46 Malnutrition
0.000 0.294 0.706
M60-M63 Disorders of muscles
0.000 0.295 0.705
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.295 0.705
E06.9 Thyroiditis, unspecified
0.000 0.296 0.704
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.296 0.704
L57.5 Actinic granuloma
0.000 0.296 0.704
L57.4 Cutis laxa senilis
0.000 0.296 0.704
L57.3 Poikiloderma of Civatte
0.000 0.296 0.704
L57.2 Cutis rhomboidalis nuchae
0.000 0.296 0.704
L57.1 Actinic reticuloid
0.000 0.296 0.704
L20 Atopic dermatitis
0.000 0.298 0.702
M07.6 Other enteropathic arthropathies
0.000 0.299 0.701
M07.5 Arthropathy in ulcerative colitis
0.000 0.299 0.701
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.299 0.701
M07.2 Psoriatic spondylitis
0.000 0.299 0.701
M07.1 Arthritis mutilans
0.000 0.299 0.701
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.299 0.701
B25 Cytomegaloviral disease
0.000 0.299 0.701
E10.8 With unspecified complications
0.000 0.299 0.700
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.300 0.700
M06.3 Rheumatoid nodule
0.000 0.300 0.700
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.301 0.699
L25 Unspecified contact dermatitis
0.000 0.301 0.699
L24 Irritant contact dermatitis
0.000 0.301 0.699
L23 Allergic contact dermatitis
0.000 0.301 0.699
L21 Seborrhoeic dermatitis
0.000 0.301 0.699
L26 Exfoliative dermatitis
0.000 0.301 0.699
L22 Diaper [napkin] dermatitis
0.000 0.301 0.699
L10-L14 Bullous disorders
0.000 0.303 0.697
E27.1 Primary adrenocortical insufficiency
0.000 0.305 0.695
A30-A49 Other bacterial diseases
0.000 0.307 0.693
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.307 0.693
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.308 0.692
M07.38 Other psoriatic arthropathies (Other)
0.000 0.309 0.691
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.309 0.691
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.309 0.691
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.309 0.691
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.309 0.691
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.309 0.691
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.309 0.691
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.309 0.691
M80-M85 Disorders of bone density and structure
0.000 0.310 0.690
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.311 0.689
Chapter XXII Codes for special purposes
0.000 0.313 0.687
Chapter II Neoplasms
0.000 0.315 0.685
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.315 0.685
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.315 0.685
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.315 0.685
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.315 0.685
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.315 0.685
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.315 0.685
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.315 0.685
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.315 0.685
D86.0 Sarcoidosis of lung
0.000 0.317 0.683
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.318 0.682
M91-M94 Chondropathies
0.000 0.318 0.682
L04 Acute lymphadenitis
0.000 0.318 0.682
L01 Impetigo
0.000 0.318 0.682
L00 Staphylococcal scalded skin syndrome
0.000 0.318 0.682
E14 Unspecified diabetes mellitus
0.000 0.318 0.681
J11 Influenza, virus not identified
0.000 0.319 0.681
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.000 0.320 0.680
L29.8 Other pruritus
0.000 0.320 0.680
L29.3 Anogenital pruritus, unspecified
0.000 0.320 0.680
L29.1 Pruritus scroti
0.000 0.320 0.680
E55 Vitamin D deficiency
0.000 0.320 0.680
M35.0 Sicca syndrome [Sjogren]
0.000 0.321 0.679
B20-B24 Human immunodeficiency virus [HIV] disease
0.000 0.321 0.679
M31.3 Wegener's granulomatosis
0.000 0.322 0.678
M34.9 Systemic sclerosis, unspecified
0.000 0.323 0.677
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.328 0.672
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.330 0.670
C44.7 Skin of lower limb, including hip
0.000 0.332 0.668
C44.1 Skin of eyelid, including canthus
0.000 0.333 0.667
B37.0 Candidal stomatitis
0.000 0.334 0.666
D68.8 Other specified coagulation defects
0.000 0.335 0.665
M11 Other crystal arthropathies
0.000 0.336 0.664
B34.9 Viral infection, unspecified
0.000 0.336 0.664
E05.5 Thyroid crisis or storm
0.000 0.336 0.664
E05.4 Thyrotoxicosis factitia
0.000 0.336 0.664
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.336 0.664
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.336 0.664
M22 Disorders of patella
0.000 0.336 0.664
E13 Other specified diabetes mellitus
0.000 0.337 0.663
M80 Osteoporosis with pathological fracture
0.000 0.337 0.663
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.337 0.663
D64.4 Congenital dyserythropoietic anaemia
0.000 0.339 0.661
D64.3 Other sideroblastic anaemias
0.000 0.339 0.661
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.339 0.661
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.339 0.661
D64.0 Hereditary sideroblastic anaemia
0.000 0.339 0.661
L08.1 Erythrasma
0.000 0.339 0.661
L08.0 Pyoderma
0.000 0.339 0.661
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.000 0.341 0.659
B99-B99 Other infectious diseases
0.000 0.342 0.658
D66 Hereditary factor VIII deficiency
0.000 0.343 0.657
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.343 0.657
M35.8 Other specified systemic involvement of connective tissue
0.000 0.343 0.657
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.343 0.657
M35.5 Multifocal fibrosclerosis
0.000 0.343 0.657
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.343 0.657
M35.2 Behcet's disease
0.000 0.343 0.657
M35.1 Other overlap syndromes
0.000 0.343 0.657
E06.5 Other chronic thyroiditis
0.000 0.344 0.656
E06.4 Drug-induced thyroiditis
0.000 0.344 0.656
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.344 0.656
E06.1 Subacute thyroiditis
0.000 0.344 0.656
E06.0 Acute thyroiditis
0.000 0.344 0.656
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.344 0.656
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.344 0.656
M32 Systemic lupus erythematosus
0.000 0.344 0.656
B49 Unspecified mycosis
0.000 0.344 0.656
M00-M03 Infectious arthropathies
0.000 0.345 0.655
J40 Bronchitis, not specified as acute or chronic
0.000 0.346 0.654
E03.8 Other specified hypothyroidism
0.000 0.346 0.654
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.000 0.346 0.654
L42 Pityriasis rosea
0.000 0.347 0.653
B85-B89 Pediculosis, acariasis and other infestations
0.000 0.347 0.653
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.000 0.347 0.653
A75-A79 Rickettsioses
0.000 0.347 0.653
A70-A74 Other diseases caused by chlamydiae
0.000 0.347 0.653
A65-A69 Other spirochaetal diseases
0.000 0.347 0.653
A20-A28 Certain zoonotic bacterial diseases
0.000 0.347 0.653
D86.9 Sarcoidosis, unspecified
0.000 0.349 0.651
C34 Malignant neoplasm of bronchus and lung
0.000 0.349 0.651
J22 Unspecified acute lower respiratory infection
0.000 0.349 0.651
L05 Pilonidal cyst
0.000 0.350 0.650
A80-A89 Viral infections of the central nervous system
0.000 0.350 0.650
M05.8 Other seropositive rheumatoid arthritis
0.000 0.351 0.649
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.351 0.649
M05.2 Rheumatoid vasculitis
0.000 0.351 0.649
M05.1 Rheumatoid lung disease
0.000 0.351 0.649
M05.0 Felty's syndrome
0.000 0.351 0.649
D67 Hereditary factor IX deficiency
0.000 0.351 0.649
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.351 0.649
D61.8 Other specified aplastic anaemias
0.000 0.351 0.649
D61.3 Idiopathic aplastic anaemia
0.000 0.351 0.649
D61.2 Aplastic anaemia due to other external agents
0.000 0.351 0.649
D61.1 Drug-induced aplastic anaemia
0.000 0.351 0.649
D61.0 Constitutional aplastic anaemia
0.000 0.351 0.649
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.000 0.353 0.647
J09 Influenza due to certain identified influenza virus
0.000 0.353 0.647
E53.8 Deficiency of other specified B group vitamins
0.000 0.356 0.644
M33 Dermatopolymyositis
0.000 0.357 0.643
J44 Other chronic obstructive pulmonary disease
0.000 0.357 0.643
D53 Other nutritional anaemias
0.000 0.360 0.640
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.360 0.640
J30-J39 Other diseases of upper respiratory tract
0.000 0.361 0.639
J15 Bacterial pneumonia, not elsewhere classified
0.000 0.362 0.638
M10 Gout
0.000 0.362 0.638
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.362 0.637
D68.6 Other Thrombophilia
0.000 0.363 0.637
M30 Polyarteritis nodosa and related conditions
0.000 0.365 0.635
E27.8 Other specified disorders of adrenal gland
0.000 0.366 0.634
J46 Status asthmaticus
0.000 0.367 0.633
D64.8 Other specified anaemias
0.000 0.370 0.630
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.370 0.630
J17 Pneumonia in diseases classified elsewhere
0.000 0.371 0.629
D50.1 Sideropenic dysphagia
0.000 0.372 0.628
M14.6 Neuropathic arthropathy
0.000 0.372 0.628
A08 Viral and other specified intestinal infections
0.000 0.373 0.627
E73 Lactose intolerance
0.000 0.374 0.626
J18.2 Hypostatic pneumonia, unspecified
0.000 0.375 0.625
A15-A19 Tuberculosis
0.000 0.375 0.625
D84 Other immunodeficiencies
0.000 0.376 0.624
D83 Common variable immunodeficiency
0.000 0.376 0.624
D82 Immunodeficiency associated with other major defects
0.000 0.376 0.624
D81 Combined immunodeficiencies
0.000 0.376 0.624
B65-B83 Helminthiases
0.000 0.376 0.624
C34.9 Bronchus or lung, unspecified
0.000 0.380 0.620
L08.8 Other specified local infections of skin and subcutaneous tissue
0.000 0.380 0.620
C34.1 Upper lobe, bronchus or lung
0.000 0.380 0.620
D68.0 Von Willebrand's disease
0.000 0.382 0.618
B48 Other mycoses, not elsewhere classified
0.000 0.383 0.617
B47 Mycetoma
0.000 0.383 0.617
B46 Zygomycosis
0.000 0.383 0.617
B45 Cryptococcosis
0.000 0.383 0.617
B43 Chromomycosis and phaeomycotic abscess
0.000 0.383 0.617
B42 Sporotrichosis
0.000 0.383 0.617
B41 Paracoccidioidomycosis
0.000 0.383 0.617
B40 Blastomycosis
0.000 0.383 0.617
B39 Histoplasmosis
0.000 0.383 0.617
B38 Coccidioidomycosis
0.000 0.383 0.617
B36 Other superficial mycoses
0.000 0.383 0.617
D68.4 Acquired coagulation factor deficiency
0.000 0.383 0.617
D68.1 Hereditary factor XI deficiency
0.000 0.383 0.617
J84 Other interstitial pulmonary diseases
0.000 0.383 0.617
J10.1 Influenza with other respiratory manifestations, influenza virus identified
0.000 0.383 0.617
A49 Bacterial infection of unspecified site
0.000 0.383 0.617
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.384 0.616
D80 Immunodeficiency with predominantly antibody defects
0.000 0.389 0.611
E67 Other hyperalimentation
0.000 0.389 0.610
E68 Sequelae of hyperalimentation
0.000 0.389 0.610
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.000 0.390 0.610
M06.4 Inflammatory polyarthropathy
0.000 0.391 0.609
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.391 0.608
E63 Other nutritional deficiencies
0.000 0.391 0.608
E56 Other vitamin deficiencies
0.000 0.391 0.608
E51 Thiamine deficiency
0.000 0.391 0.608
E50 Vitamin A deficiency
0.000 0.391 0.608
E60 Dietary zinc deficiency
0.000 0.391 0.608
E59 Dietary selenium deficiency
0.000 0.391 0.608
E58 Dietary calcium deficiency
0.000 0.391 0.608
E54 Ascorbic acid deficiency
0.000 0.391 0.608
E52 Niacin deficiency [pellagra]
0.000 0.391 0.608
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.392 0.608
B50-B64 Protozoal diseases
0.000 0.394 0.606
B25.9 Cytomegaloviral disease, unspecified
0.000 0.395 0.605
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.395 0.605
J41 Simple and mucopurulent chronic bronchitis
0.000 0.396 0.604
D51 Vitamin B12 deficiency anaemia
0.000 0.396 0.603
E89.0 Postprocedural hypothyroidism
0.000 0.399 0.601
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.399 0.601
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.399 0.601
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.399 0.601
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.399 0.601
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.399 0.601
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.399 0.601
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.399 0.601
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.399 0.601
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.400 0.600
L30 Other dermatitis
0.000 0.400 0.600
L28.0 Lichen simplex chronicus
0.000 0.401 0.599
B37.7 Candidal septicaemia
0.000 0.401 0.599
B37.6 Candidal endocarditis
0.000 0.401 0.599
B37.5 Candidal meningitis
0.000 0.401 0.599
B37.2 Candidiasis of skin and nail
0.000 0.401 0.599
B37.1 Pulmonary candidiasis
0.000 0.401 0.599
B33 Other viral diseases, not elsewhere classified
0.000 0.402 0.598
B30 Viral conjunctivitis
0.000 0.402 0.598
B27 Infectious mononucleosis
0.000 0.402 0.598
B26 Mumps
0.000 0.402 0.598
B90-B94 Sequelae of infectious and parasitic diseases
0.000 0.402 0.598
J32 Chronic sinusitis
0.000 0.403 0.597
J00-J06 Acute upper respiratory infections
0.000 0.406 0.594
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.408 0.592
E26 Hyperaldosteronism
0.000 0.408 0.592
E84 Cystic fibrosis
0.000 0.409 0.591
E79 Disorders of purine and pyrimidine metabolism
0.000 0.409 0.591
E77 Disorders of glycoprotein metabolism
0.000 0.409 0.591
E76 Disorders of glycosaminoglycan metabolism
0.000 0.409 0.591
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.409 0.591
E72 Other disorders of amino-acid metabolism
0.000 0.409 0.591
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.409 0.591
E70 Disorders of aromatic amino-acid metabolism
0.000 0.409 0.591
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.409 0.591
E80.4 Gilbert's syndrome
0.000 0.409 0.590
E74 Other disorders of carbohydrate metabolism
0.000 0.410 0.590
J35 Chronic diseases of tonsils and adenoids
0.000 0.410 0.590
D86.8 Sarcoidosis of other and combined sites
0.000 0.410 0.589
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.000 0.412 0.588
E65 Localised adiposity
0.000 0.414 0.586
C64-C68 Malignant neoplasms of urinary tract
0.000 0.414 0.586
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.416 0.584
B35 Dermatophytosis
0.000 0.419 0.581
L82 Seborrhoeic keratosis
0.000 0.423 0.577
A63.0 Anogenital (venereal) warts
0.000 0.423 0.577
L83 Acanthosis nigricans
0.000 0.423 0.577
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.425 0.575
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.425 0.574
J35.0 Chronic tonsillitis
0.000 0.425 0.575
D62 Acute posthaemorrhagic anaemia
0.000 0.426 0.574
D59 Acquired haemolytic anaemia
0.000 0.427 0.573
J20 Acute bronchitis
0.000 0.428 0.572
E27.9 Disorder of adrenal gland, unspecified
0.000 0.431 0.569
E11 Non-insulin-dependent diabetes mellitus
0.000 0.432 0.568
L27.9 Dermatitis due to unspecified substance taken internally
0.000 0.432 0.568
L27.8 Dermatitis due to other substances taken internally
0.000 0.432 0.568
L27.2 Dermatitis due to ingested food
0.000 0.432 0.568
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.432 0.568
D52.9 Folate deficiency anaemia, unspecified
0.000 0.432 0.567
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.000 0.433 0.567
D86.3 Sarcoidosis of skin
0.000 0.434 0.566
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.434 0.566
D86.1 Sarcoidosis of lymph nodes
0.000 0.434 0.566
E88 Other metabolic disorders
0.000 0.436 0.564
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.436 0.564
A08.1 Acute gastro-enteropathy due to Norwalk agent
0.000 0.438 0.562
M14.8 Arthropathies in other specified diseases classified elsewhere
0.000 0.439 0.561
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.439 0.561
M14.4 Arthropathy in amyloidosis
0.000 0.439 0.561
M14.3 Lipoid dermatoarthritis
0.000 0.439 0.561
M14.2 Diabetic arthropathy
0.000 0.439 0.561
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.439 0.561
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.439 0.561
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.439 0.561
E32 Diseases of thymus
0.000 0.439 0.561
E31 Polyglandular dysfunction
0.000 0.439 0.561
E30 Disorders of puberty, not elsewhere classified
0.000 0.439 0.561
E25 Adrenogenital disorders
0.000 0.439 0.561
E20 Hypoparathyroidism
0.000 0.439 0.561
C44.6 Skin of upper limb, including shoulder
0.000 0.441 0.559
E55.9 Vitamin D deficiency, unspecified
0.000 0.442 0.558
L03 Cellulitis
0.000 0.443 0.557
M34.8 Other forms of systemic sclerosis
0.000 0.443 0.557
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.443 0.557
M34.1 CR(E)ST syndrome
0.000 0.443 0.557
M34.0 Progressive systemic sclerosis
0.000 0.443 0.557
J12 Viral pneumonia, not elsewhere classified
0.000 0.444 0.556
A02 Other Salmonella infections
0.000 0.445 0.555
E04.1 Non-toxic single thyroid nodule
0.000 0.446 0.554
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.448 0.552
J21 Acute bronchiolitis
0.000 0.449 0.551
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.449 0.551
E66.0 Obesity due to excess calories
0.000 0.451 0.549
E05.8 Other thyrotoxicosis
0.000 0.451 0.549
E27.5 Adrenomedullary hyperfunction
0.000 0.452 0.547
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.452 0.547
E27.2 Addisonian crisis
0.000 0.452 0.547
E27.0 Other adrenocortical overactivity
0.000 0.452 0.547
L43.9 Lichen planus, unspecified
0.000 0.454 0.546
A60 Anogenital herpesviral [herpes simplex] infections
0.000 0.454 0.546
A59 Trichomoniasis
0.000 0.454 0.546
A56 Other sexually transmitted chlamydial diseases
0.000 0.454 0.546
A54 Gonococcal infection
0.000 0.454 0.546
A53 Other and unspecified syphilis
0.000 0.454 0.546
A52 Late syphilis
0.000 0.454 0.546
A51 Early syphilis
0.000 0.454 0.546
A50 Congenital syphilis
0.000 0.454 0.546
A64 Unspecified sexually transmitted disease
0.000 0.454 0.546
A58 Granuloma inguinale
0.000 0.454 0.546
A57 Chancroid
0.000 0.454 0.546
A55 Chlamydial lymphogranuloma (venereum)
0.000 0.454 0.546
L02.3 Cutaneous abscess, furuncle and carbuncle of buttock
0.000 0.456 0.543
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.458 0.542
B15-B19 Viral hepatitis
0.000 0.458 0.542
L28.2 Other prurigo
0.000 0.458 0.542
L28.1 Prurigo nodularis
0.000 0.458 0.542
E66.1 Drug-induced obesity
0.000 0.459 0.541
E07 Other disorders of thyroid
0.000 0.460 0.540
B34.8 Other viral infections of unspecified site
0.000 0.460 0.540
J42 Unspecified chronic bronchitis
0.000 0.460 0.539
C44.0 Skin of lip
0.000 0.461 0.539
E61 Deficiency of other nutrient elements
0.000 0.461 0.539
M31.9 Necrotising vasculopathy, unspecified
0.000 0.462 0.538
M31.8 Other specified necrotising vasculopathies
0.000 0.462 0.538
M31.7 Microscopic polyangiitis
0.000 0.462 0.538
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.462 0.538
M31.2 Lethal midline granuloma
0.000 0.462 0.538
M31.1 Thrombotic microangiopathy
0.000 0.462 0.538
M31.0 Hypersensitivity angiitis
0.000 0.462 0.538
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites
0.000 0.462 0.538
C34.0 Main bronchus
0.000 0.462 0.538
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.000 0.464 0.536
M93 Other osteochondropathies
0.000 0.466 0.534
E04.2 Non-toxic multinodular goitre
0.000 0.469 0.531
J32.8 Other chronic sinusitis
0.000 0.470 0.530

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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